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https://www.readbyqxmd.com/read/29327281/effect-of-early-natal-supplementation-of-paracetamol-on-attenuation-of-exotoxin-endotoxin-induced-pyrexia-and-precipitation-of-autistic-like-features-in-albino-rats
#1
Abdulaziz S Saeedan, Indu Singh, Mohd Nazam Ansari, Manjari Singh, Jitendra K Rawat, Uma Devi, Swetlana Gautam, Rajnish K Yadav, Gaurav Kaithwas
The present study was aimed to test the hypothesis that paracetamol (PCM) can precipitate autistic like features when used to counteract vaccine-induced fever using experimental rat pups. The pups were treated with measles mumps rubella (MMR) vaccine, diphtheria tetanus and pertussis (DPT) vaccines and lipopolysaccharide (LPS) with subsequent PCM treatment. The pups were evaluated for postnatal growth (weight gain, eye opening) and behavior alterations (swimming performance, olfactory discrimination, negative geotaxis, nociception, and locomotor activity) by performing battery of neurobehavioral test...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29325483/characterization-of-vaccination-policies-for-attendance-and-employment-at-day-summer-camps-in-new-york-state
#2
William A Prescott, Kelsey C Violanti, Nicholas M Fusco
INTRODUCTION: New York state requires day/summer camps to keep immunization records for all enrolled campers and strongly recommends requiring vaccination for all campers and staff. The objective of this study was to characterize immunization requirements/recommendations for children/adolescents enrolled in and staff employed at day/summer camps in New York state. METHODS: An electronic hyperlink to a 9-question survey instrument was distributed via e-mail to 178 day/summer camps located in New York state cities with a population size greater than 100 000 people...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29324728/recommendation-of-the-advisory-committee-on-immunization-practices-for-use-of-a-third-dose-of-mumps-virus-containing-vaccine-in-persons-at-increased-risk-for-mumps-during-an-outbreak
#3
Mona Marin, Mariel Marlow, Kelly L Moore, Manisha Patel
A substantial increase in the number of mumps outbreaks and outbreak-associated cases has occurred in the United States since late 2015 (1,2). To address this public health problem, the Advisory Committee on Immunization Practices (ACIP) reviewed the available evidence and determined that a third dose of measles, mumps, rubella (MMR) vaccine is safe and effective at preventing mumps. During its October 2017 meeting, ACIP recommended a third dose of a mumps virus-containing vaccine* for persons previously vaccinated with 2 doses who are identified by public health authorities as being part of a group or population at increased risk for acquiring mumps because of an outbreak...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29320811/vaccination-policies-requirements-and-exemptions-for-entering-school
#4
Erik Skinner
(1) According to the World Health Organization, immunization prevents between 2 million to 3 million deaths every year across the world. (2) When immunization rates are high, herd immunity develops and limits the spread of the disease, which helps protect those who cannot be vaccinated. (3) Vaccination rates for measles, mumps and rubella vary across the United States, ranging from 85.6 percent in Washington, D.C., to 99.4 percent in Mississippi.
December 2017: NCSL Legisbrief
https://www.readbyqxmd.com/read/29319529/seroprevalence-of-rubella-and-cytomegalia-in-young-women-from-bia%C3%A5-a-podlaska-district
#5
Dorota Plewik, Małgorzata Tokarska-Rodak, Justyna Paszkiewicz, Adam Szepeluk
The aim of this study was to analyze the seroprevalence of rubella and cytomegalia among young women. The study included 175 healthy women from the Biała Podlaska District, aged 16 to 35 years. Anti-rubella and anti-CMV IgG were determined by ELISA. 172 (98.3%) study subjects tested positive for rubella antibodies, 1 (0.6%) was seroindeterminate and 2 (1.1%) were seronegative. CMV antibodies were detected in 119 (68.0%) participants; the series included also 1 (0.6%) seroindeterminate and 55 (31.4%) seronegative women...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29317560/a-new-combined%C3%A2-vaccine%C3%A2-against-measles-mumps-rubella-and-varicella-in-india
#6
Nitin Shah, Raunak Parikh, Giacomo Casabona, Shafi Kolhapure
A quadrivalent MMRV (measles-mumps-rubella-varicella) combination vaccine has recently been launched in India. This vaccine is highly immunogenic, with seroconversion rates against all antigens reaching 96.6-100% at 42 to 56 days after the second vaccine dose in unvaccinated children or in those previously vaccinated with MMR+/-V. Two doses efficacy, against all varicella is 94.1% and effectiveness reaches 91%. The most frequent solicited local adverse event after MMRV vaccine is redness, and fever is the most common solicited general symptom...
December 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29317117/measles-mumps-and-rubella-antibody-patterns-of-persistence-and-rate-of-decline-following-the-second-dose-of-the-mmr-vaccine
#7
Emma E Seagle, Robert A Bednarczyk, Tenisha Hill, Amy Parker Fiebelkorn, Carole J Hickman, Joseph P Icenogle, Edward A Belongia, Huong Q McLean
BACKGROUND: Antibodies to measles, mumps, and rubella decline 3% per year on average, and have a high degree of individual variation. Yet, individual variations and differences across antigens are not well understood. To better understand potential implications on individual and population susceptibility, we reanalyzed longitudinal data to identify patterns of seropositivity and persistence. METHODS: Children vaccinated with the second dose of measles, mumps, rubella vaccine (MMR2) at 4-6 years of age were followed up to 12 years post-vaccination...
January 6, 2018: Vaccine
https://www.readbyqxmd.com/read/29309372/assessment-of-humoral-immunity-to-hepatitis-b-measles-rubella-and-mumps-in-children-after-chemotherapy
#8
Zuhal Keskin Yildirim, Mustafa Buyukavci
BACKGROUND: Cancer survival rates and longevity of patients after therapy have significantly improved during the last few decades. Therefore, lasting protection against infections should be provided. PROCEDURE: A total of 162 children diagnosed with acute lymphoblastic leukemia, acute myelogenous leukemia, solid tumors, non-Hodgkin lymphoma, and Hodgkin lymphoma were enrolled in the study. Antibody levels against hepatitis B virus was assessed both at the time of diagnosis and within 6 months after completion of chemotherapy...
January 5, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29307368/measles-and-rubella-global-strategic-plan-2012-2020-midterm-review-report-background-and-summary
#9
Walter A Orenstein, Lisa Cairns, Alan Hinman, Benjamin Nkowane, Jean-Marc Olivé, Arthur L Reingold
Measles, a vaccine-preventable illness, is one of the most infectious diseases known to man. In 2015, an estimated 134,200 measles deaths occurred globally. Rubella, also vaccine-preventable, is a concern because infection during pregnancy can result in congenital defects in the baby. More than 100,000 babies with congenital rubella syndrome were estimated to have been born globally in 2010. Eradication of both measles and rubella is considered to be feasible, beneficial, and more cost-effective than high-level control...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29307367/measles-and-rubella-global-strategic-plan-2012-2020-midterm-review
#10
REVIEW
W A Orenstein, A Hinman, B Nkowane, J M Olive, A Reingold
1. Measles eradication is the ultimate goal but it is premature to set a date for its accomplishment. Existing regional elimination goals should be vigorously pursued to enable setting a global target by 2020. 2. The basic strategic approaches articulated in the Global Measles and Rubella Strategic Plan 2012-2020 are valid to achieve the goals but have not been fully implemented (or not appropriately adapted to local situations). 3. The report recommends a shift from primary reliance on supplementary immunization activities (SIAs) to assure two doses of measles-containing vaccine (MCV) are delivered to the target population to primary reliance on ongoing services to assure administration of two doses of MCV...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29306505/igg-antibody-prevalence-suggests-high-immunization-needs-in-newcomers-to-luxembourg-2012
#11
Judith M Hübschen, Emilie Charpentier, Pierre Weicherding, Claude P Muller
Vaccine coverage of the general population in Luxembourg is high, but refugees or asylum seekers may be incompletely vaccinated and susceptible to vaccine-preventable diseases. In order to assess protection rates, serum and oral fluid samples were collected from 406 newcomers aged between 13 and 70 years arriving between May and September 2012. Sera were screened for IgG antibodies against measles, rubella, mumps, hepatitis B, tetanus, diphtheria and pertussis. Oral fluid samples were screened for antibodies against measles, mumps and rubella virus to investigate their suitability for antibody prevalence studies...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29298693/rubella-natural-immunity-among-adolescent-girls-in-tanzania-the-need-to-vaccinate-child-bearing-aged-women
#12
Mariam M Mirambo, Mtebe Majigo, Seth D Scana, Martha F Mushi, Said Aboud, Uwe Groß, Benson R Kidenya, Stephen E Mshana
BACKGROUND: Rubella primary infection during early stages of pregnancy is associated with high risk of congenital Rubella syndrome (CRS). Prevention of CRS in the resource-limited countries requires multiple strategies. Here, we document the data on the magnitude of Rubella natural immunity among adolescent girls which is a crucial group in devising effective control strategies to prevent CRS. METHODS: A cross sectional study involving 397 adolescent girls was conducted in the city of Mwanza involving five secondary schools...
January 3, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29289382/head-to-head-immunogenicity-comparison-of-edmonston-zagreb-vs-aik-c-measles-vaccine-strains-in-infants-aged-8-12-months-a-randomized-clinical-trial
#13
Shahrokh Izadi, Seyed Mohsen Zahraei, Masoud Salehi, Mahdi Mohammadi, Seyed Mehdi Tabatabaei, Talat Mokhtari-Azad
BACKGROUND: A non-inferiority multi-centre parallel randomized double-blind trial was implemented in Zahedan district, Sistan-va-Baluchestan province, Iran, to compare the performance of the two measles vaccines which are in use in the National Immunization Programme of Iran and are of two different measles virus vaccine strains: Edmonston-Zagreb (EZ) strain vs. AIK-C strain. The main outcome measure was appearance of anti-measles antibody in sera. METHODS: 200 infants, 8-12 months old, whose parents consented for their children to be included in the study, were randomized in permutation blocks of size 4-8 in four Urban Health Clinics...
December 27, 2017: Vaccine
https://www.readbyqxmd.com/read/29283745/polymerase-chain-reaction-and-goldmann-witmer-coefficient-testing-in-the-diagnosis-of-infectious-uveitis-in-hiv-positive-and-hiv-negative-patients-in-south-africa
#14
Derrick P Smit, David Meyer, Tonya M Esterhuizen, Jolanda D F De Groot-Mijnes
PURPOSE: To use polymerase chain reaction (PCR) and Goldmann-Witmer coefficient (GWC) calculation to diagnose infectious uveitis. METHODS: Prospective cross-sectional study. RESULTS: Twenty-seven of 106 patients had positive PCR and/or GWC results on aqueous humor (AH) sampling and 15 of 27 (55.6%) were HIV-positive. Patients with non-anterior uveitis (NAU) were more likely to be HIV+ (p = 0.005). More than 1 possible pathogen was identified in 9 of 27 patients of whom 7 were HIV+...
December 28, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29278378/modelling-the-transmission-dynamics-and-control-of-mumps-in-mainland-china
#15
Yong Li, Xianning Liu, Lianwen Wang
Mumps is a common childhood viral disease and children have been vaccinated throughout the world since 1967. The incidence of mumps has increased with more than 300,000 young people infected with mumps annually in mainland China since 2005. Therefore, we designed and analyzed long-term mumps surveillance data in an SVEILR (susceptible-vaccinated-exposed-severely infectious-mildly infectious-recovered) dynamic transmission model with optimized parameter values to describe the dynamics of mumps infections in China...
December 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29277353/immunologic-non-inferiority-and-safety-of-the-investigational-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv-4-dose-vial-presentation-compared-to-the-licensed-phid-cv-1-dose-vial-presentation-in-infants-a-phase-iii-randomized
#16
Khalequ Zaman, Sheikh Farzana Zaman, Farzana Zaman, Asma Aziz, Sayeed-Bin Faisal, Magali Traskine, Md Ahsan Habib, Javier Ruiz-Guiñazú, Dorota Borys
BACKGROUND: To support vaccination programs in developing countries, a 4-dose vial presentation of pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) was developed. This study assessed immunologic non-inferiority and safety of the investigational PHiD-CV 4-dose versus licensed 1-dose vial presentation in infants. METHODS: In this phase III, mono-center, observer-blind study in Bangladesh, 6-10-week-old infants were randomized 1:1 to receive PHiD-CV primary vaccination (at ages 6, 10, 18 weeks) and a booster dose (at age 9 months) with a 4-dose vial (with preservative, 4DV group) or 1-dose vial (preservative-free, 1DV group)...
December 22, 2017: Vaccine
https://www.readbyqxmd.com/read/29276699/zika-virus-an-emerging-global-health-threat
#17
REVIEW
Rahul Mittal, Desiree Nguyen, Luca H Debs, Amit P Patel, George Liu, Vasanti M Jhaveri, Sae-In S Kay, Jeenu Mittal, Emmalee S Bandstra, Ramzi T Younis, Prem Chapagain, Dushyantha T Jayaweera, Xue Zhong Liu
Zika virus (ZIKV) is an emerging healthcare threat. The presence of the mosquito Aedes species across South and Central America in combination with complementary climates have incited an epidemic of locally transmitted cases of ZIKV infection in Brazil. As one of the most significant current public health concerns in the Americas, ZIKV epidemic has been a cause of alarm due to its known and unknown complications. At this point, there has been a clear association between ZIKV infection and severe clinical manifestations in both adults and neonates, including but not limited to neurological deficits such as Guillain-Barré syndrome (GBS) and microcephaly, respectively...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29276161/impact-of-vaccination-history-on-serological-testing-in-pregnant-women
#18
Michaël Desjardins, Isabelle Boucoiran, Caroline Paquet, Céline Laferrière, Anne Gosselin-Brisson, Annie-Claude Labbé, Valérie Martel-Laferrière
OBJECTIVE: Serological testing guidelines for vaccine-preventable infectious diseases in pregnant women are heterogeneous. It is unclear how vaccination history influences health care workers' (HCWs) attitudes about testing. The aim of this study was to describe current practices in screening for rubella, hepatitis B, and varicella-zoster virus (VZV) in pregnant women in the province of Québec. METHODS: In 2015, an electronic survey was distributed to HCWs who followed the case of at least one pregnant woman in the previous year and who could be contacted by email by their professional association...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29275992/variation-in-splicing-efficiency-underlies-morphological-evolution-in-capsella
#19
Ushio Fujikura, Runchun Jing, Atsushi Hanada, Yumiko Takebayashi, Hitoshi Sakakibara, Shinjiro Yamaguchi, Christian Kappel, Michael Lenhard
Understanding the molecular basis of morphological change remains a central challenge in evolutionary-developmental biology. The transition from outbreeding to selfing is often associated with a dramatic reduction in reproductive structures and functions, such as the loss of attractive pheromones in hermaphroditic Caenorhabditis elegans and a reduced flower size in plants. Here, we demonstrate that variation in the level of the brassinosteroid-biosynthesis enzyme CYP724A1 contributes to the reduced flower size of selfing Capsella rubella compared with its outbreeding ancestor Capsella grandiflora...
December 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29262493/-genetic-characterization-of-rubella-virus-isolated-in-guizhou-province-from-2012-to-2015
#20
X M Tang, Z Zhu, G Ren, X F Ye, L Zhang
Objective: To analyze the genetic characteristics of rubella virus isolated from 2012 to 2015 in Guizhou province. Methods: A total of 390 cases of suspected measles were collected from Guizhou measles network laboratory from 2012 to 2015 and 25 cases of rubella cases were diagnosed. Rubella virus isolation was performed using Vero/SLAM cells. The presence of rubella viral RNA was detected using Real-time RT-PCR after RNA extraction from infected tissue culture cells. Fragments of 480 bp and 633 bp nucleotides of E1 genes of the isolates were amplified by RT-PCR and the PCR products were sequenced and spliced...
December 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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