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https://www.readbyqxmd.com/read/29133384/estrogen-and-high-fat-diet-induced-alterations-in-c57bl-6-mice-endometrial-transcriptome-profile
#1
Yali Cheng, Qiaoying Lv, Bingying Xie, Bingyi Yang, Weiwei Shan, Chengcheng Ning, Bing Li, Liying Xie, Chao Gu, Xuezhen Luo, Xiaojun Chen, Qin Zhu
Unopposed estrogen stimulation and insulin resistance are known to play important roles in endometrial cancer (EC), but the interaction between these two factors and how they contribute to endometrial lesions are not completely elucidated. To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous implantation of 17-β estradiol (E2) pellet and/or high-fat diet (HFD) for 12 weeks to mimic sustained estrogen stimulation and insulin resistance...
November 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28986927/effects-of-phyto-oestrogen-quercetin-on-productive-performance-hormones-reproductive-organs-and-apoptotic-genes-in-laying-hens
#2
J X Yang, M T Chaudhry, J Y Yao, S N Wang, B Zhou, M Wang, C Y Han, Y You, Y Li
Quercetin, a polyphenolic flavonoid with diverse biological activities including anti-inflammatory and antiviral, inhibits lipid peroxidation, prevents oxidative injury and cell death. The purpose of the research was to investigate the effect of quercetin on productive performance, reproductive organs, hormones and apoptotic genes in laying hens between 37 and 45 weeks of age, because of the structure and oestrogenic activities similar to 17β-oestradiol. The trial was conducted using 240 Hessian laying hens (37 weeks old), housed in wire cages with two hens in each cage...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28888896/hormonal-profile-and-follicular-dynamics-concurrent-with-cidr-and-insulin-modified-ovsync-tai-programs-and-their-impacts-on-the-fertility-response-in-buffaloes
#3
A A Ramoun, A M Emara, B A Heleil, S A Darweish, H A Abou-Ghait
Fifty one cyclic Egyptian buffaloes were used to study the hormonal profile and follicular dynamics concurrent with CIDR and insulin modified Ovsync TAI programs and their impacts on the consequent fertility responses. The buffaloes were randomly assigned into 3 ovulation synchronization protocols: Ovsync-alone (n = 13, control) CIDR-sync (n = 20) and Insulin-sync (n = 18). Ovsync-alone protocol consisted of two im injections of 20 μg bueserlin (GnRHa) on Day 0 (GnRH 1) and on Day 9 (GnRH 2) with an im injection of 500 μg of cloprostenol sodium (PGF2 α) on Day 7...
August 19, 2017: Theriogenology
https://www.readbyqxmd.com/read/28888597/mechanisms-linking-metabolic-stress-with-innate-immunity-in-the-endometrium
#4
I Martin Sheldon, James G Cronin, Mateusz Pospiech, Matthew L Turner
Bacterial infections of the uterus after parturition are ubiquitous in dairy cattle and often cause uterine disease, such as metritis or endometritis. However, the metabolic stress associated with milk production increases the risk of developing disease. Resolution of bacterial infections requires rapid and robust innate immune responses, which depend on host cell receptors recognizing pathogen-associated molecular patterns, such as lipopolysaccharide (LPS) from gram-negative bacteria. Here, we argue that metabolic stress impairs the inflammatory response to pathogens...
September 6, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28868248/the-window-of-implantation-is-closed-by-estrogen-via-insulin-like-growth-factor-1-pathway
#5
Ryosuke Kobayashi, Jumpei Terakawa, Tsutomu Omatsu, Yupadee Hengjan, Tetsuya Mizutani, Yasushige Ohmori, Eiichi Hondo
BACKGROUND: The opening and closing of the implantation window is important for successful pregnancy in eutherians. The recent study demonstrated that the window of uterine receptivity was prepared by the sole action of progesterone in mice, but the mechanism to close the window remained to be elucidated. METHODS: The pregnant mice were ovariectomized on the evening on the third day of pregnancy with a single injection of medroxyprogesterone acetate to induce delayed implantation (DI)...
April 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28748857/effect-of-high-fat-diet-induced-disorders-on-rat-with-endometrial-hyperplasia-and-adiponectin-system-in-circulation-and-uterus
#6
Chen-Guang Shang, Zhao-Hui Liu, Xiao-Hui Wang, Zong-Hao Feng, Yan Zhang
BACKGROUND: Epidemiologic and genetic studies suggest a link between insulin resistance (IR) and endometrial cancer, and endometrial hyperplasia (EH) is a precancerous stage of endometrial cancer. Adiponectin is an adipokine which previously shown to be a risk factor for endometrial cancer. The aim of the study was to develop a rat model of IR and EH and evaluate adiponectin system in circulation and uterus. METHODS: This study was a 46-week animal trial from February 2014 to January 2015...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28743351/chronic-stress-effects-and-their-reversibility-on-the-fallopian-tubes-and-uterus-in-rats
#7
S Divyashree, H N Yajurvedi
The durational effects of chronic stress on the Fallopian tubes and uterus were studied by exposing rats to stressors in the form of restraint (1h) and forced swimming (15min) daily for 4, 8 or 12 weeks. One group of stressed rats from each time period was then maintained without exposure to stressors for a further 4 weeks to assess their ability to recover from stress. All time periods of stress exposure resulted in decreased weight of the body and Fallopian tubes; however, the relative weight of the uterus and serum concentrations of oestradiol and insulin increased significantly...
July 26, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28682900/doege-potter-syndrome-a-review-of-the-literature-including-a-new-case-report
#8
REVIEW
Guiyan Han, Zhimin Zhang, Xingbin Shen, Kunpeng Wang, Yang Zhao, Jianqiu He, Yu Gao, Xiujie Shan, Guohua Xin, Chunhui Li, Xiaoyan Liu
RATIONALE: We reviewed 76 published cases of Doege-Potter syndrome, and non-islet cell tumor hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT) between 1989 and 2016, to study disease pathogenesis, diagnosis, and treatment of this rare paraneoplastic disease. Further, we report 1 new case of a patient presenting with Doege-Potter syndrome. PATIENTS CONCERNS: The tumors originated from the pleural cavity, lung, pelvis, liver, retroperitoneum, kidney, mediastinal, the sella, uterus, bladder, intestine, mandibular, and the thigh...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28674230/cdna-cloning-structural-analysis-snp-detection-and-tissue-expression-profile-of-the-igf1-gene-in-malabari-and-attappady-black-goats-of-india
#9
Thomas Naicy, Thirupathy Venkatachalapathy, Thazhathuveettil Aravindakshan, Kunniyoor Cheemani Raghavan, Mangattumuruppel Mini, Kulangara Shyama
Insulin-like growth factor 1 (IGF1) plays an important role in growth, reproduction, foetal development and cell proliferation. The present study was conducted to clone and sequence the full-length coding sequence of the caprine IGF1 gene from Attappady Black and Malabari breeds, two indigenous goat breeds of south India, to analyse its structure, and to ascertain the relative abundance of IGF1 mRNA in different tissues. The caprine IGF1 cDNA (GenBank accession nos: KJ549851 and KJ549852) contained a 465-bp open reading frame encoding IGF1 protein with 154 amino acid residues...
June 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28586424/role-of-er%C3%AE-in-mediating-female-uterine-transcriptional-responses-to-igf1
#10
Sylvia C Hewitt, Wipawee Winuthayanon, Sydney L Lierz, Katherine J Hamilton, Lauren J Donoghue, J Tyler Ramsey, Sara A Grimm, Yukitomo Arao, Kenneth S Korach
Estrogen (E2) signaling through its nuclear receptor, E2 receptor α (ERα) increases insulinlike growth factor 1 (IGF1) in the rodent uterus, which then initiates further signals via the IGF1 receptor. Directly administering IGF1 results in similar biological and transcriptional uterine responses. Our studies using global ERα-null mice demonstrated a loss of uterine biological responses of the uterus to E2 or IGF1 treatment, while maintaining transcriptional responses to IGF1. To address this discrepancy in the need for uterine ERα in mediating the IGF1 transcriptional vs growth responses, we assessed the IGF1 transcriptional responses in PgrCre+Esr1f/f (called ERαUtcKO) mice, which selectively lack ERα in progesterone receptor (PGR) expressing cells, including all uterine cells, while maintaining ERα expression in other tissues and cells that do not express Pgr...
August 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28522033/placenta-directed-gene-therapy-for-fetal-growth-restriction
#11
REVIEW
Tara Krishnan, Anna L David
Fetal growth restriction (FGR) is a serious pregnancy complication affecting ∼8% of all pregnancies. There is no treatment to increase fetal growth in the uterus. Gene therapy presents a promising treatment strategy for FGR, with the use of adenoviral vectors encoding for proteins such as vascular endothelial growth factor (VEGF) and insulin-like growth factor demonstrating improvements in fetal growth, placental function, and neonatal outcome in preclinical studies. Safety assessments suggest no adverse risk to the mother or fetus for VEGF maternal gene therapy; a clinical trial is in development...
May 15, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28467127/markers-of-obesity-and-growth-in-preeclamptic-and-normotensive-pregnant-women
#12
S Kharb, J Bala, S Nanda
The objective of the study was to analyse leptin, IGF-1, Apo A, lipoproteins, haem oxygenase-1 (HO-1) in maternal sera and venous umbilical cord sera of newborn babies of 25 preeclamptics (group II), and 25 normotensive pregnant women (group I) as markers of obesity and growth in preeclamptic and normotensive pregnant women. Apo A I and II levels were estimated by competitive immunoassay using direct chemiluminiscence technology. Haem oxygenase-1 (HO-1), leptin and IGF-1 were analysed by ELISA. Maternal and cord blood levels of homocysteine, folic acid, lipid profile (namely, total cholesterol, triglycerides, LDL-C, VLDL-C and HDL-C), Haem oxygenase 1 were higher in preeclamptic women as compared to normotensive pregnant women...
May 3, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28428227/mechanisms-in-endocrinology-the-multiple-facets-of-ghrh-gh-igf-i-axis-lessons-from-lifetime-untreated-isolated-gh-deficiency-due-to-a-ghrh-receptor-gene-mutation
#13
REVIEW
Manuel H Aguiar-Oliveira, Anita H O Souza, Carla R P Oliveira, Viviane C Campos, Luíz A Oliveira-Neto, Roberto Salvatori
Twenty years ago, we described kindred of 105 individuals with isolated GH deficiency (IGHD) in Itabaianinha County, in northeast Brazil, carrying a homozygous mutation in the GH-releasing hormone receptor gene. These subjects exhibit markedly reduced GH responsiveness to stimulatory tests, and anterior pituitary hypoplasia. Serum concentrations of IGF-I, IGF binding protein type 3 and the acid-labile subunit are markedly reduced, with a lesser reduction of IGF-II. The most striking physical findings of these IGHD individuals are the proportionate short stature, doll facies, high-pitched voice and visceral obesity with reduced fat-free mass...
August 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28336389/metformin-ameliorates-uterine-defects-in-a-rat-model-of-polycystic-ovary-syndrome
#14
Yuehui Zhang, Min Hu, Fanci Meng, Xiaoyan Sun, Hongfei Xu, Jiao Zhang, Peng Cui, Njomeza Morina, Xin Li, Wei Li, Xiao-Ke Wu, Mats Brännström, Ruijin Shao, Håkan Billig
Adult rats treated concomitantly with insulin and human chorionic gonadotropin exhibit endocrine, metabolic, and reproductive abnormalities that are very similar to those observed in polycystic ovary syndrome (PCOS) patients. In this study, we used this rat model to assess the effects of metformin on PCOS-related uterine dysfunction. In addition to reducing androgen levels, improving insulin sensitivity, and correcting the reproductive cycle, metformin treatment induced morphological changes in the PCOS-like uterus...
April 2017: EBioMedicine
https://www.readbyqxmd.com/read/28161306/a-randomized-clinical-trial-of-exercise-during-pregnancy%C3%A2-to%C3%A2-prevent-gestational-diabetes-mellitus-and%C3%A2-improve-pregnancy-outcome-in-overweight-and%C3%A2-obese%C3%A2-pregnant-women
#15
RANDOMIZED CONTROLLED TRIAL
Chen Wang, Yumei Wei, Xiaoming Zhang, Yue Zhang, Qianqian Xu, Yiying Sun, Shiping Su, Li Zhang, Chunhong Liu, Yaru Feng, Chong Shou, Kym J Guelfi, John P Newnham, Huixia Yang
BACKGROUND: Obesity and being overweight are becoming epidemic, and indeed, the proportion of such women of reproductive age has increased in recent times. Being overweight or obese prior to pregnancy is a risk factor for gestational diabetes mellitus, and increases the risk of adverse pregnancy outcome for both mothers and their offspring. Furthermore, the combination of gestational diabetes mellitus with obesity/overweight status may increase the risk of adverse pregnancy outcome attributable to either factor alone...
April 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28109592/short-communication-limitations-of-glucose-tolerance-tests-in-the-assessment-of-peripheral-tissue-insulin-sensitivity-during-pregnancy-and-lactation-in-dairy-heifers
#16
J De Koster, M Van Eetvelde, K Hermans, W Van den Broeck, M Hostens, G Opsomer
The aim of the present study was to point at the limitations of glucose tolerance tests (GTT) to assess peripheral tissue insulin sensitivity in dairy heifers in different physiological states (pregnancy and lactation). Intravenous GTT were performed in 5 nonpregnant, nonlactating heifers, 5 heifers at the end of pregnancy (12-7 d before calving), and 5 lactating primiparous cows (11-14 d after calving). Glucose and insulin concentrations were determined and area under the curve (AUC) and clearance rate of glucose and insulin were calculated...
March 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28102491/shedding-new-light-on-female-fertility-the-role-of-vitamin-d
#17
REVIEW
Giovanna Muscogiuri, Barbara Altieri, Cristina de Angelis, Stefano Palomba, Rosario Pivonello, Annamaria Colao, Francesco Orio
In the last decades several studies suggested that vitamin D is involved in the modulation of the reproductive process in women due to the expression of VDR and 1α-hydroxylase in reproductive tissues such as ovary, uterus, placenta, pituitary and hypothalamus. Vitamin D has also a role in the regulation of sex hormone steroidogenesis. Increasing evidence suggests that vitamin D might have a regulatory role in polycystic ovary syndrome (PCOS)-associated symptoms, including ovulatory dysfunction, insulin resistance and hyperandrogenism...
September 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28091641/effects-of-pomegranate-extract-in-supplementing-gonadotropin-releasing-hormone-therapy-on-idiopathic-central-precocious-puberty-in-chinese-girls-a-randomized-placebo-controlled-double-blind-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Jinsheng Liu, Jiulai Tang
Central precocious puberty (CPP) without organic abnormality is called idiopathic CPP (ICPP). The objective of this trial was to evaluate the effects of pomegranate extract in supplementing gonadotropin-releasing hormone (GnRH) analog therapy on ICPP-affected girls in the Chinese population. 286 girls, diagnosed with ICPP were initially enrolled into this trial, and among them 225 eligible patients were randomized to receive a combinational GnRH analog treatment supplemented with either a placebo or pomegranate extract on a daily basis for a period of 3 months...
February 22, 2017: Food & Function
https://www.readbyqxmd.com/read/27777110/altered-expression-of-mirnas-in-the-uterus-from-a-letrozole-induced-rat-pcos-model
#19
Chunjin Li, Lu Chen, Yun Zhao, Shuxiong Chen, Lulu Fu, Yanwen Jiang, Shan Gao, Zhuo Liu, Fengge Wang, Xiaoling Zhu, Jiahui Rao, Jing Zhang, Xu Zhou
Polycystic ovary syndrome (PCOS) causes female subfertility with ovarian disorders and may be associated with increased rate of early-pregnancy failure. Rat PCOS models were established using letrozole to understand the uterine pathogenesis of PCOS. The differential expression of microRNAs (miRNAs) was observed in rat uterus with PCOS. After estrous cycles were disrupted, significantly abnormal ovarian morphology and hormone level were observed in rats with PCOS. A total of 148 miRNAs differentially expressed were identified in the uterus from the letrozole-induced rat model compared with the control...
January 20, 2017: Gene
https://www.readbyqxmd.com/read/27665193/interaction-of-bombesin-and-its-fragments-with-gold-nanoparticles-analyzed-using-surface-enhanced-raman-spectroscopy
#20
REVIEW
Agnieszka Tąta, Aleksandra Szkudlarek, Younkyoo Kim, Edyta Proniewicz
This work demonstrates the application of commercially available stable surface composed of gold nanograins with diameters ranging from 70 to 226nm deposited onto silicon wafer for surface-enhanced Raman scattering investigations of biologically active compounds, such as bombesin (BN) and its fragments. BN is an important neurotransmitter involved in a complex signaling pathways and biological responses; for instance, hypertensive action, contractive on uterus, colon or ileum, locomotor activity, stimulation of gastric and insulin secretion as well as growth promotion of various tumor cell lines, including: lung, prostate, stomach, colon, and breast...
February 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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