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https://www.readbyqxmd.com/read/29228105/metformin-attenuates-susceptibility-to-inflammation-induced-preterm-birth-in-mice-with-higher-endocannabinoid-levels
#1
Xiaofei Sun, Alexandra Tavenier, Wenbo Deng, Emma Leishman, Heather B Bradshaw, Sudhansu K Dey
Premature decidual senescence is a contributing factor to preterm birth. Fatty acid amide hydrolase mutant females (Faah-/-) with higher endocannabinoid levels are also more susceptible to preterm birth upon lipopolysaccharide (LPS) challenge due to enhanced decidual senescence; this is associated with MAPK p38 activation. Previous studies have shown that mammalian target of rapamycin complex 1 (mTORC1) contributes to decidual senescence and promotes the incidence of preterm birth. In the present study, we sought to attenuate premature decidual aging in Faah-/- females by targeting mTORC1 and p38 signaling pathways...
December 5, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29227951/transcriptome-analysis-reveals-novel-genes-involved-in-anthocyanin-biosynthesis-in-the-flesh-of-peach
#2
Ke Cao, Tiyu Ding, Dongmin Mao, Gengrui Zhu, Weichao Fang, Changwen Chen, Xinwei Wang, Lirong Wang
Peach is an important deciduous fruit tree species. Anthocyanins play an important role in fruit color formation and, through linkage analysis, previous studies have identified and mapped the key genes regulating anthocyanins' accumulation to chromosomes 3 and 5 in two different germplasms. To understand the overall regulatory network of anthocyanins biosynthesis, genes co-expressed with these key genes were identified in the red-fleshed 'Tianjin Shui Mi' and white-fleshed 'Hakuho' germplasms. Analysis of their flesh anthocyanin contents revealed differences 15 days before maturation...
December 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29227774/tooth-fairy-guilty-of-favouritism
#3
Raphael Patcas, Hubertus Jm van Waes, Moritz M Daum, Markus A Landolt
OBJECTIVES: To determine the proportion of children visited by the Tooth Fairy, the child-related factors that influence the likelihood of her visit, and the parent-related variables that affect the amount of money the Tooth Fairy leaves. DESIGN: Cross-sectional questionnaire study. SETTING: Zürich, Switzerland. PARTICIPANTS: 3617 parents of children (mean age of children, 6.8 years; 51.9% girls) who had lost at least one deciduous tooth received a self-developed questionnaire; 1274 questionnaires were returned (35...
December 11, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29227245/clearance-of-senescent-decidual-cells-by-uterine-natural-killer-cells-in-cycling-human-endometrium
#4
Paul J Brighton, Yojiro Maruyama, Katherine Fishwick, Pavle Vrljicak, Shreeya Tewary, Risa Fujihara, Joanne Muter, Emma S Lucas, Taihei Yamada, Laura Woods, Raffaella Lucciola, Yie Hou Lee, Satoru Takeda, Sascha Ott, Myriam Hemberger, Siobhan Quenby, Jan Joris Brosens
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), leading to cell cycle exit and differentiation into decidual cells that control embryo implantation. Here we show that FOXO1 also causes acute senescence of a subpopulation of decidualizing EnSCs in an IL-8 dependent manner. Selective depletion or enrichment of this subpopulation revealed that decidual senescence drives the transient inflammatory response associated with endometrial receptivity...
December 11, 2017: ELife
https://www.readbyqxmd.com/read/29216626/evidence-for-hmgn2-involvement-in-mouse-embryo-implantation-and-decidualization
#5
Dang-Dang Li, Liang Yue, Zhan-Qing Yang, Lian-Wen Zheng, Bin Guo
BACKGROUND/AIMS: Hmgn2 is involved in regulating embryonic development, but its physiological function during embryo implantation and decidualization remains unknown. METHODS: In situ hybridization, real-time PCR, RNA interference, gene overexpression and MTS assay were used to examine the expression of Hmgn2 in mouse uterus during the pre-implantation period and explore its function and regulatory mechanisms in epithelial adhesion junction and stromal cell proliferation and differentiation...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29214886/clinical-and-molecular-aspects-of-lead-toxicity-an-update
#6
Prasenjit Mitra, Shailja Sharma, Purvi Purohit, Praveen Sharma
Lead toxicity is a major public health issue in developed and developing countries. Both acute and chronic lead exposure has the potential to cause many deleterious systematic effects including hypertension, frank anemia, cognitive deficits, infertility, immune imbalances, delayed skeletal and deciduous dental development, vitamin D deficiency, and gastrointestinal effects. The underlying mechanisms for all these systemic effects have not been elucidated completely. However, the most plausible cause is free radical damage...
December 7, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29211131/in-vitro-evaluation-of-the-remineralizing-potential-and-antimicrobial-activity-of-a-cariostatic-agent-with-silver-nanoparticles
#7
Beatriz Brandão Scarpelli, Marília Franco Punhagui, Márcio Grama Hoeppner, Ricardo Sergio Couto de Almeida, Felipe Augusto Juliani, Ricardo Danil Guiraldo, Sandrine Bittencourt Berger
Cariostatic treatment has been shown to successfully arrest caries. However, it blackens the carious tooth structure. This study evaluated the effects of an experimental cariostatic agent with silver nanoparticles (Ag-Nano) using microhardness (MH) and microbiological tests. The cariostatic agents tested were: Saforide®, Cariestop®, Ancarie® and Ag-Nano. Sixty-six samples from deciduous enamel were submitted to initial (after pH cycling to obtain initial caries-like lesion) and final (after cariostatic application) MH testing and %MH values were calculated...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29209348/phylogeography-study-of-the-siberian-apricot-prunus-sibirica-l-in-northern-china-assessed-by-chloroplast-microsatellite-and-dna-makers
#8
Zhe Wang, Yanfei Zeng, Zhendong Zhang, Songbai Sheng, Ju Tian, Rongling Wu, Xiaoming Pang
There is evidence that a band of dry climate separated plants in East Asia into distinct northern and southern groups. However, few studies have focused on the arid belt in this region, especially with regard to plants. We analyzed genetic variation in 22 populations of Siberian apricot (Prunus sibirica L.), a temperate deciduous species distributed in this arid belt, using two chloroplast DNA (cpDNA) sequences, seven chloroplast microsatellite loci (cpSSRs), and 31 nuclear microsatellite loci (nSSRs), to study its phylogeography...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29209083/maintenance-of-carbohydrate-transport-in-tall-trees
#9
Jessica A Savage, Sierra D Beecher, Laura Clerx, Jessica T Gersony, Jan Knoblauch, Juan M Losada, Kaare H Jensen, Michael Knoblauch, N Michele Holbrook
Trees present a critical challenge to long-distance transport because as a tree grows in height and the transport pathway increases in length, the hydraulic resistance of the vascular tissue should increase. This has led many to question whether trees can rely on a passive transport mechanism to move carbohydrates from their leaves to their roots. Although species that actively load sugars into their phloem, such as vines and herbs, can increase the driving force for transport as they elongate, it is possible that many trees cannot generate high turgor pressures because they do not use transporters to load sugar into the phloem...
December 2017: Nature Plants
https://www.readbyqxmd.com/read/29208797/caries-preventive-effect-of-sodium-fluoride-varnish-on-deciduous-dentition-a-clinical-trial
#10
Swapnil K Patil, Madhura Fatangare, Rutuj G Jadhav, Gaurav R Shinde, Siddhi S Pawar, Mitesh D Kathariya
AIM: The aim of the study is to evaluate the efficacy of intensive application of sodium fluoride varnish in reducing caries incidence among children aged 6 to 7 years. MATERIALS AND METHODS: The study was a randomized controlled trial conducted among 6- to 7-year-old children of Sangamner, Maharashtra, India. Nearly 200 randomly selected children were randomized into two groups: Control group and intervention (varnish) group. Dental examination to record the caries experiences was conducted at baseline and at 1-year follow-up...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29207838/in-vitro-evaluation-of-resin-infiltrant-penetration-into-white-spot-lesions-of-deciduous-molars
#11
Dinesh Francis Swamy, Elaine Savia Barretto, Shanthala B Mallikarjun, Sapna Sada Raut Dessai
Introduction: Caries Infiltration is a recent microinvasive restorative technique that permits treatment of non-cavitated demineralized lesions, known as White Spot Lesions (WSL). Aim: To evaluate the extent of penetration of a commercially available resin caries-infiltrant into natural WSL occurring in deciduous tooth enamel. Materials and Methods: Deciduous molars with natural WSL on any smooth surface were selected and sectioned into halves to yield equal control and experimental groups...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207297/differences-between-a-deciduous-and-a-conifer-tree-species-in-gaseous-and-particulate-emissions-from-biomass-burning
#12
Emanuele Pallozzi, Ilaria Lusini, Lucia Cherubini, Ramilla A Hajiaghayeva, Paolo Ciccioli, Carlo Calfapietra
In the Mediterranean ecosystem, wildfires are very frequent and the predicted future with a probable increase of fires could drastically modify the vegetation scenarios. Vegetation fires are an important source of gases and primary emissions of fine carbonaceous particles in the atmosphere. In this paper, we present gaseous and particulate emissions data from the combustion of different plant tissues (needles/leaves, branches and needle/leaf litter), obtained from one conifer (Pinus halepensis) and one deciduous broadleaf tree (Quercus pubescens)...
December 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29203340/decidual-acvr2a-regulates-extravillous-trophoblast-functions-of-adhesion-proliferation-migration-and-invasion-in-vitro
#13
Hannah E J Yong, Padma Murthi, Bill Kalionis, Rosemary J Keogh, Shaun P Brennecke
Decidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration and invasion; all effects that were attenuated by decidual ACVR2A siRNA transfection...
November 14, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29202469/h3k27me3-dynamics-dictate-evolving-uterine-states-in-pregnancy-and-parturition
#14
Patrice Nancy, Johan Siewiera, Gabrielle Rizzuto, Elisa Tagliani, Ivan Osokine, Priyanka Manandhar, Igor Dolgalev, Caterina Clementi, Aristotelis Tsirigos, Adrian Erlebacher
Uncovering the causes of pregnancy complications such as preterm labor requires greater insight into how the uterus remains in a noncontractile state until term and then surmounts this state to enter labor. Here, we show that dynamic generation and erasure of the repressive histone modification tri-methyl histone H3 lysine 27 (H3K27me3) in decidual stromal cells dictate both elements of pregnancy success in mice. In early gestation, H3K27me3-induced transcriptional silencing of select gene targets ensured uterine quiescence by preventing the decidua from expressing parturition-inducing hormone receptors, manifesting type 1 immunity, and most unexpectedly, generating myofibroblasts and associated wound-healing responses...
November 27, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29201128/a-highlighted-case-for-emphasizing-on-clinical-diagnosis-for-rare-syndrome-in-third-world
#15
Fatemeh Owlia, Mohammad-Hassan Akhavan Karbassi, Roqayeh Hakimian, Mohammad Sadegh Alemrajabi
Premature tooth loss is a disastrous situation that affects deciduous or permanent teeth era with different causes. It may be attributed to some disorders like Papillon-Lefevre syndrome or coffin-lowry syndrome but because of ambiguous nature, precise diagnosis is not easily possible. Moreover, it has very low incidence and defines by few and limited case series, with vague characters to some extent, confusion in detecting the right diagnosis is a common possibility. Hence, it is expectable to have a wrong diagnosis for this case...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29200500/expansion-of-deciduous-tall-shrubs-but-not-evergreen-dwarf-shrubs-inhibited-by-reindeer-in-scandes-mountain-range
#16
Tage Vowles, Bengt Gunnarsson, Ulf Molau, Thomas Hickler, Leif Klemedtsson, Robert G Björk
One of the most palpable effects of warming in Arctic ecosystems is shrub expansion above the tree line. However, previous studies have found that reindeer can influence plant community responses to warming and inhibit shrubification of the tundra.We revisited grazed (ambient) and ungrazed study plots (exclosures), at the southern as well as the northern limits of the Swedish alpine region, to study long-term grazing effects and vegetation changes in response to increasing temperatures between 1995 and 2011, in two vegetation types (shrub heath and mountain birch forest)...
November 2017: Journal of Ecology
https://www.readbyqxmd.com/read/29199334/-effect-of-transfected-ephb4-on-osteogenic-differentiation-in-stem-cells-from-human-exfoliated-deciduous-teeth
#17
Xiao-Ming Li, Chang-Yong Yuan, Shao-Yue Zhu, Zong-Xiang Liu, Peng-Lai Wang
PURPOSE: To evaluate the effect of stem cells from human exfoliated deciduous teeth (SHED) transfected with EphB4 gene in regulating osteogenic differentiation. METHODS: Human dental pulp tissue were harvested from extracted deciduous teeth and digested by collagenase and dispase. The SHEDs were transfected with transgenic (hEphB4-GFP) vector or empty vector (GFP-vector). Real time-polymerase chain reaction(real time-PCR) analysis and Western blot were used to detect the expression of EphB4 in SHEDs after transfection...
August 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29197148/decidual-cd68-hla-dr-cd163-m1-macrophages-increase-in-miscarriages-with-normal-fetal-chromosome
#18
Shigeki Shimada, Yasuhiko Ebina, Norifumi Iijima, Masashi Deguchi, Hideto Yamada
PROBLEM: Is an abnormal increase or decrease of M1/M2 macrophages observed in the deciduae of miscarriages with normal fetal chromosome (MN)? METHODS OF STUDY: Deciduae of 18 MN and 26 miscarriages with abnormal fetal chromosome (MA) were obtained. Additionally, deciduae from 15 women whose pregnancies ended in induced abortions (IA) and endometriums at the mid-luteal phase from 19 non-pregnant women endomeriums of mid-luteal phases (EM) were obtained. Macrophages were analyzed by flow cytometry using monoclonal antibodies for CD68, HLA-DR, and CD163...
December 2, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29193806/inhibition-of-larval-growth-and-adult-fecundity-in-asian-long-horned-beetle-anoplophora-glabripennis-exposed-to-azadirachtins-under-quarantine-laboratory-conditions
#19
Dean G Thompson, Amanda Tonon, Eduardo Beltran, Felix Hernandez
BACKGROUND: The Asian Long-horned Beetle (ALB; Anoplophora glabripennis (Motschulsky)), is an invasive, wood-boring insect posing significant economic and ecological threats to the deciduous forests of North America. An efficacious and environmentally acceptable chemical control technique is a requirement of a comprehensive, integrated response strategy. RESULTS: Results of this study demonstrate statistically significant, concentration-dependent effects of azadirachtins, a family of natural compounds derived from the neem tree, on both ALB larval and adult life-stages...
November 28, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29190657/tree-seedlings-respond-to-both-light-and-soil-nutrients-in-a-patagonian-evergreen-deciduous-forest
#20
Alvaro Promis, Robert B Allen
Seedlings of co-occurring species vary in their response to resource availability and this has implications for the conservation and management of forests. Differential shade-tolerance is thought to influence seedling performance in mixed Nothofagus betuloides-Nothofagus pumilio forests of Patagonia. However, these species also vary in their soil nutrient requirements. To determine the effects of light and soil nutrient resources on small seedlings we examined responses to an experimental reduction in canopy tree root competition through root trenching and restricting soil nutrient depletion through the addition of fertilizer...
2017: PloS One
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