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Tianyang Gao, Yingqiu Liang, Haiyu Tang, Li Quan
OBJECTIVE: This study was to determinate the expression of Tspan5 in tubal ectopic implantation sites and to explore the correlation of the expressive level of Tspan5 at maternal-fetal interface and the occurrence of tubal ectopic pregnancy. STUDY DESIGN: This is a retrospective study. Trophoblastic and endometrial tissues were collected from tubal ectopic pregnancy(Total of 40), and intrauterine pregnancy(Total of 41), who had voluntary abortion, non-pregnancy women(Total of 12), who recieved an diagnostic uterine curettage before IVF-ET for male infertility...
June 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Mohsen Ahmadi, Morteza Naderi, Mohammad Kaboli, Masoud Nazarizadeh, Mahmoud Karami, Sara M Beitollahi
We used the fat dormouse (Glis glis), a species from a monotypic genus of family Gliridae, as a model to promote the understanding of patterns of cryptic diversification along the ancient Hyrcanian Forests, one of the old-growth relicts of the temperate deciduous forests worldwide. Mitochondrial Cytb data was used to investigate the phylogenetic status of two geographically-different populations of G. glis along the Hyrcanian Forests among all the worldwide known lineages of the species. Regarding phylogenetically informed partitioning of occurrence data, we then used two analytically different ENMs (i...
June 12, 2018: Molecular Phylogenetics and Evolution
Andrew V Gougherty, Steven W Gougherty
While much research has focused on the timing of individual plant phenological events, the sequence of phenological events has received considerably less attention. Here we identify drivers and patterns of flower and leaf emergence sequence (FLS) in deciduous tree species of the Great Lakes region of North America. Five hypotheses related to cold tolerance, water dynamics, seed mass, pollination syndrome, and xylem anatomy type were compared for their ability to explain FLS. Phylogenetic and geographic patterns of FLS were also assessed...
June 14, 2018: New Phytologist
Rong Mao, Xinhou Zhang, Changchun Song, Xianwei Wang, Patrick M Finnegan
In boreal peatlands, litter decomposition plays an important role in modulating ecosystem carbon (C) cycling and nutrient turnover. However, how climate warming and plant functional group interact to affect litter decomposition is still unclear in these ecosystems. Here, we collected fresh litters of six plant functional groups (nitrogen (N)-fixing species, deciduous tree, deciduous shrub, evergreen shrub, graminoid, and Sphagnum moss) from a boreal peatland located in northeast China. A laboratory incubation experiment was used to determine the effect of temperature (10 °C vs...
June 1, 2018: Science of the Total Environment
Isabella Mota-Veloso, Maria Letícia Ramos-Jorge, Marcio Alexandre Homem, Isabela Almeida Pordeus, Saul Martins Paiva, Fernanda Oliveira-Ferreira
Attention-deficit/hyperactivity disorder (ADHD) is characterized by inappropriate levels of hyperactivity, impulsivity, and/or inattention. Individuals with ADHD may present limitations with regard to executive functions and performing activities that involve planning and/or attention/concentration. The aim of the study was to investigate the association between dental caries and signs of ADHD in a representative sample of schoolchildren. A representative sample of 851 schoolchildren aged seven to 12 years was randomly selected from public and private schools...
June 7, 2018: Brazilian Oral Research
Rodney A Prell, Noel Dybdal, Akihiro Arima, Yutaka Chihaya, Ihsan Nijem, Wendy Halpern
Onartuzumab is an engineered single arm, monovalent monoclonal antibody that targets the MET receptor and prevents HGF signaling. Knockout mice have clearly demonstrated that HGF/MET signaling is developmentally critical. A pre- and post-natal development (PPND) study (enhanced design) was conducted in cynomolgus monkeys to evaluate the potential developmental consequences following onartuzumab administration. Control or onartuzumab, at loading/maintenance doses of 75/50 mg/kg (low) or 100/100 mg/kg (high), was administered intravenously once weekly to 12 confirmed pregnant female cynomolgus monkeys per group from gestation day (GD) 20 through GD 174...
June 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Pier Luigi Meroni, Maria Orietta Borghi, Claudia Grossi, Cecilia Beatrice Chighizola, Paolo Durigutto, Francesco Tedesco
Recurrent thrombosis and miscarriages are the main clinical manifestations of antiphospholipid syndrome (APS). Although most patients display both clinical signs, some patients can have isolated vascular or obstetric variants. Emerging data raise the question of whether obstetric and vascular APS are the same or different diseases. An important difference between the two conditions is that a thrombophilic state is a common feature in vascular APS, whereas clot occlusions of the decidual spiral arteries are seldom observed in obstetric APS, and infarctions are found in only one-third of APS placentae...
June 11, 2018: Nature Reviews. Rheumatology
Yvonne Koch, Pauline Wimberger, Ruth Grümmer
Endometriosis, characterized by the presence of endometrial tissue at ectopic sites, is a leading cause of pelvic pain and subfertility in women. The stromal compartment of the endometrium is considered to play a pivotal role in the establishment and persistence of endometriotic lesions, thus impaired decidualization of these cells may result in enhanced invasion capacity at ectopic sites. Consequently, stimulation of decidualization may alleviate this disease. To analyze the effect of systemically applied compounds on decidualization of ectopic endometrial tissue, endometriosis was induced by suturing human eutopic endometrium to the peritoneum of 22 NOD/SCID mice...
January 1, 2018: Experimental Biology and Medicine
Lita Sacks
OBJECTIVE: This paper reports the first published case of a prehistoric human with five or more supernumerary teeth. Such cases are often neglected in paleopathology, in part due to a gap between the medicodental and anthropological literature leading to the view in anthropology that supernumerary teeth are curious anomalies rather than pathologies. DESIGN: Reconstruction and pathological description of the skeletal remains were performed according to standard osteological protocols...
June 4, 2018: Archives of Oral Biology
Dean Whiting, Whasun Oh Chung, James D Johnson, Avina Paranjpe
INTRODUCTION: Dental stem cells have gained importance recently and are being used for various purposes in regenerative medicine and dentistry. Although much research has been done to show the various properties of these dental stem cells, the immunomodulatory properties of some of these stem cells are still unknown. This is important considering these cells are being used routinely. Therefore, the aim of this study was to investigate the interactions between the activated immune cells and 3 types of dental-derived mesenchymal stem cells: dental pulp stem cells, stem cells from human exfoliated deciduous teeth, and stem cells of the apical papilla (SCAP)...
June 5, 2018: Journal of Endodontics
Melanie C Audette, Khrystyna Levytska, Stephen J Lye, Nir Melamed, John C Kingdom
INTRODUCTION: Rates of some placental-associated pregnancy complications vary by ethnicity, though the strength of association with underlying placental pathology is presently unknown. Our objective was to determine whether an association between ethnicity and placental pathology occurs in low-risk pregnancies. METHODS: 829 low-risk nulliparous pregnant women were prospectively studied. Data were obtained from standardized obstetrical appointments (clinical history, serum biomarkers, placental ultrasound) and hospital delivery records (pregnancy complications, delivery details and perinatal outcomes)...
June 2018: Placenta
Luciana Bueno de Freitas, Christiane Curi Pereira, Paulo Roberto Merçon-de-Vargas, Liliana Cruz Spano
Early miscarriage is still a concern, and viral infections are recognised as one of the causes of this adverse outcome. The causal relationship between HPV and miscarriage remains controversial. The aim of the study was to evaluate whether HPV infection indeed may occur in both the maternal and placental tissue in cases of miscarriage. Decidual and chorionic villi fragments (n = 118) were dissected from 81 miscarriage cases, 68 spontaneous and 13 intentional. HPV DNA was detected using the consensus primers MY09/11; in eight cases (9...
June 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Annekatrin Dreyer, Frank Neugebauer, Heinz Rüdel, Roland Klein, Nina Lohmann, Caren Rauert, Jan Koschorreck
Coniferous shoots and deciduous tree leaf samples from 10 sites in Germany were taken in 2015 or 2016 within the German Environmental Specimen Bank sampling program and analysed for 24 polybrominated biphenyl ethers (PBDEs) and 19 additional halogenated flame retardants (HFRs). At one site, additional historic samples dating back till 2003 were also investigated. Samples were Soxhlet-extracted, cleaned-up by a non-destructive multi-step procedure involving gel permeation chromatography, and detected by GC-API-MS/MS as well as GC-MS...
May 7, 2018: Chemosphere
Seon-Hee Kim, Myong-Suk Cho, Pan Li, Seung-Chul Kim
Alternating glacial and interglacial periods during the Quaternary have dramatically affected the distribution and population genetic structure of plant and animal species throughout the northern hemisphere. Surprisingly, little is known about the post-glacial recolonization history of wetland herbaceous perennials that are widely distributed in the understory of deciduous or mixed deciduous-evergreen forests in eastern North America. In this study, we investigated infraspecific variation among 32 populations of skunk cabbage, Symplocarpus foetidus , to test the hypothesis that the extant species diversity of skunk cabbage is the result of a post-glacial range expansion from southern refugia during the Quaternary Ice Age...
2018: Frontiers in Plant Science
Brita M Svensson, Bengt Å Carlsson, Jerry M Melillo
A seven-year long, two-factorial experiment using elevated temperatures (5 °C) and CO2 (concentration doubled compared to ambient conditions) designed to test the effects of global climate change on plant community composition was set up in a Subarctic ecosystem in northernmost Sweden. Using point-frequency analyses in permanent plots, an increased abundance of the deciduous Vaccinium myrtillus , the evergreens V. vitis-idaea and Empetrum nigrum ssp. hermaphroditum and the grass Avenella flexuosa was found in plots with elevated temperatures...
2018: PeerJ
Giacomo Puglielli, Laura Varone
The covariation pattern among leaf functional traits involved in resource acquisition has been successfully provided by the leaf economic spectrum (LES). Nevertheless, some aspects such as how the leaf trait variation sources affect LES predictions are still little investigated. Accordingly, the aim of this paper was to test whether leaf trait variations within different leaf cohorts could alter LES. Improving this knowledge can extend the potential of trait-based approaches in simulating future climate effects on ecosystems...
June 2018: AoB Plants
Anne Schumacher, Stefanie Ehrentraut, Markus Scharm, Hongsheng Wang, Roland Hartig, Herbert C Morse, Ana Claudia Zenclussen
B cells possess various immuno regulatory functions. However, research about their participation in tolerance induction toward the fetus is just emerging. Accumulating evidence supports the idea that B cells can play seemingly conflicting roles during pregnancy, either protecting or harming the fetus. Previous findings indicated the presence of two different peritoneal B cell subsets, defined by the expression of the plasma cell alloantigen 1 (PC1) and with distinct immune modulatory functions. Here, we aimed to study the participation of these two B cell subsets, on pregnancy outcome in a murine model of disturbed fetal tolerance...
2018: Frontiers in Immunology
Jiahui Ding, Xiujuan Tan, Kunkun Song, Wenwen Ma, Jing Xiao, Yufan Song, Mingmin Zhang
Bushen Huoxue recipe (BSHXR) is a classic Chinese herbal prescription for nourishing the kidney and activating blood circulation. It consists of six herbs: Astragali radix , Angelicae sinensis radix , Ligustici Chuanxiong Rhizoma , Cuscutae semen , Taxilli Herba , and Dipsaci Radix , and the main active constituents of BSHXR are ferulic acid, calycosin-7-glucopyranoside, hyperoside, quercitrin, and asperosaponin VI. In clinical practice, BSHXR is traditionally used to treat failed pregnancy and its complications...
2018: Frontiers in Pharmacology
Marcin R Tatara, Anna Szabelska, Witold Krupski, Barbara Tymczyna, Iwona Łuszczewska-Sierakowska, Jarosław Bieniaś, Monika Ostapiuk
Interrelationships between morphological, densitometric, and mechanical properties of deciduous mandibular teeth (incisors, canine, second premolar) were investigated. To perform morphometric, densitometric, and mechanical analyses, teeth were obtained from 5-month-old sheep. Measurements of mean volumetric tooth mineral density and total tooth volume were performed using quantitative computed tomography. Microcomputed tomography was used to measure total enamel volume, volumetric enamel mineral density, total dentin volume, and volumetric dentin mineral density...
June 2018: Journal of Veterinary Dentistry
Mandee Yang, Grace Eun Nam, Atriya Salamati, Michael Baldwin, Mengzhao Deng, Zi-Jun Liu
Objective: To address how experimental periodontal disease affects alveolar bone mass and mineral apposition in a young pig model. Materials and methods: Seven three-month-old pigs were periodically inoculated with 4 types of periodontal bacteria, along with a ligature around the last maxillary deciduous molar for 8 weeks to induce periodontal disease (PG). Eight same-aged pigs served as the control (CG). Segmentations of 3D cone-beam CT images were performed to quantify volumes of the total alveolar bone, alveolar ridge, and all roots of the target molar...
March 2018: Heliyon
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