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https://www.readbyqxmd.com/read/29340590/efficacy-and-safety-of-deep-brain-stimulation-in-tourette-syndrome-the-international-tourette-syndrome-deep-brain-stimulation-public-database-and-registry
#1
Daniel Martinez-Ramirez, Joohi Jimenez-Shahed, James Frederick Leckman, Mauro Porta, Domenico Servello, Fan-Gang Meng, Jens Kuhn, Daniel Huys, Juan Carlos Baldermann, Thomas Foltynie, Marwan I Hariz, Eileen M Joyce, Ludvic Zrinzo, Zinovia Kefalopoulou, Peter Silburn, Terry Coyne, Alon Y Mogilner, Michael H Pourfar, Suketu M Khandhar, Man Auyeung, Jill Louise Ostrem, Veerle Visser-Vandewalle, Marie-Laure Welter, Luc Mallet, Carine Karachi, Jean Luc Houeto, Bryan Timothy Klassen, Linda Ackermans, Takanobu Kaido, Yasin Temel, Robert E Gross, Harrison C Walker, Andres M Lozano, Benjamin L Walter, Zoltan Mari, William S Anderson, Barbara Kelly Changizi, Elena Moro, Sarah Elizabeth Zauber, Lauren E Schrock, Jian-Guo Zhang, Wei Hu, Kyle Rizer, Erin H Monari, Kelly D Foote, Irene A Malaty, Wissam Deeb, Aysegul Gunduz, Michael S Okun
Importance: Collective evidence has strongly suggested that deep brain stimulation (DBS) is a promising therapy for Tourette syndrome. Objective: To assess the efficacy and safety of DBS in a multinational cohort of patients with Tourette syndrome. Design, Setting, and Participants: The prospective International Deep Brain Stimulation Database and Registry included 185 patients with medically refractory Tourette syndrome who underwent DBS implantation from January 1, 2012, to December 31, 2016, at 31 institutions in 10 countries worldwide...
January 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29328886/osteochondral-graft-size-is-significantly-associated-with-increased-force-and-decreased-chondrocyte-viability
#2
Brian E Walczak, Matthew S Nies, Darrin J Trask, Scott Hetzel, Patrick J Roney, Matthew W Squire, Geoffrey S Baer
BACKGROUND: Insertion force has been shown to significantly reduce chondrocyte viability during osteochondral allograft transplantation. How graft size influences the required insertion force and chondrocyte viability has yet to be determined. Hypothesis/Purpose: The purpose was to characterize how graft size influences insertion force requirements and chondrocyte viability during osteochondral transplantation. The hypothesis was that larger grafts would require greater force and reduce chondrocyte viability...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29300918/detection-of-cocaine-and-metabolites-in-bone-following-decomposition-using-2d-lc-ms-ms
#3
Malorie Mella, Brendan Schweitzer, Claude R Mallet, Tara Moore, Sabra Botch-Jones
Introduction: In forensic toxicology, challenges exist with quantification analysis of cocaine and metabolites in postmortem samples following extensive decomposition. Alternative matrices, such as bone could prove useful when other specimens are not available. Detection and quantification of drugs in complex matrices require time-consuming extraction processes. The objective of this study was to develop a robust extraction and clean-up methodology to efficiently extract cocaine, and its metabolites, in bone and reach target limits of detection using multidimensional chromatography...
December 28, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29287080/serum-apolipoprotein-a1-and-haptoglobin-in-patients-with-suspected-drug-induced-liver-injury-dili-as-biomarkers-of-recovery
#4
Valentina Peta, Chantal Tse, Hugo Perazzo, Mona Munteanu, Yen Ngo, An Ngo, Nittia Ramanujam, Lea Verglas, Maxime Mallet, Vlad Ratziu, Dominique Thabut, Marika Rudler, Vincent Thibault, Ina Schuppe-Koistinen, Dominique Bonnefont-Rousselot, Bernard Hainque, Françoise Imbert-Bismut, Michael Merz, Gerd Kullak-Ublick, Raul Andrade, Florian van Boemmel, Eckart Schott, Thierry Poynard
BACKGROUND: There is a clear need for better biomarkers of drug-induced-liver-injury (DILI). AIMS: We aimed to evaluate the possible prognostic value of ActiTest and FibroTest proteins apoliprotein-A1, haptoglobin and alpha-2-macroglobulin, in patients with DILI. METHODS: We analyzed cases and controls included in the IMI-SAFE-T-DILI European project, from which serum samples had been stored in a dedicated biobank. The analyses of ActiTest and FibroTest had been prospectively scheduled...
2017: PloS One
https://www.readbyqxmd.com/read/29285664/pectoralis-minor-transfer-for-elbow-flexion-restoration-in-late-obstetric-brachial-plexus-palsy
#5
Vanessa Costil, Claudia Romana, Frank Fitoussi
PURPOSE: Obstetric brachial plexus palsy (OBPP) may result in a severe impairment of upper limb function, especially when major motor functions do not recover with or without early microsurgical reconstruction. Various methods to restore elbow flexion have been described. The aim of this study was to report the results after pectoralis minor transfer for elbow flexion restoration in late OBPP. METHODS: Nineteen patients were included. Mean age at surgery was six years (range, 2...
December 28, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29282072/a-pilot-study-to-understand-feasibility-and-acceptability-of-stool-and-cord-blood-sample-collection-for-a-large-scale-longitudinal-birth-cohort
#6
S R Bailey, C L Townsend, H Dent, C Mallet, E Tsaliki, E M Riley, M Noursadeghi, T D Lawley, A J Rodger, P Brocklehurst, N Field
BACKGROUND: Few data are available to guide biological sample collection around the time of birth for large-scale birth cohorts. We are designing a large UK birth cohort to investigate the role of infection and the developing immune system in determining future health and disease. We undertook a pilot to develop methodology for the main study, gain practical experience of collecting samples, and understand the acceptability of sample collection to women in late pregnancy. METHODS: Between February-July 2014, we piloted the feasibility and acceptability of collecting maternal stool, baby stool and cord blood samples from participants recruited at prolonged pregnancy and planned pre-labour caesarean section clinics at University College London Hospital...
December 28, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29250873/the-entry-of-salmonella-in-a-distinct-tight-compartment-revealed-at-high-temporal-and-ultrastructural-resolution
#7
Jennifer Fredlund, José Carlos Santos, Virginie Stévenin, Allon Weiner, Patricia Latour-Lambert, Katya Rechav, Adeline Mallet, Jacomine Krijnse-Locker, Michael Elbaum, Jost Enninga
Salmonella enterica induces membrane ruffling and genesis of macropinosomes during its interactions with epithelial cells. This is achieved through the type three secretion system-1 (T3SS-1), which first mediates bacterial attachment to host cells and then injects bacterial effector proteins to alter host behavior. Next, Salmonella enters into the targeted cell within an early membrane-bound compartment that matures into a slow growing, replicative niche called the Salmonella Containing Vacuole (SCV). Alternatively, the pathogen disrupts the membrane of the early compartment and replicate at high rate in the cytosol...
December 18, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29239015/treating-hepatic-encephalopathy-in-cirrhotic-patients-admitted-to-icu-with-sodium-phenylbutyrate-a-preliminary-study
#8
Nicolas Weiss, Simona Tripon, Marion Lodey, Elsa Guiller, Helga Junot, Denis Monneret, Julien Mayaux, Hélène Brisson, Maxime Mallet, Marika Rudler, Françoise Imbert-Bismut, Dominique Thabut
Hepatic encephalopathy (HE) influences short and long-term prognosis. Recently, glycerol phenylbutyrate (PB), that lowers ammonia by providing an alternate pathway to urea for waste nitrogen excretion, has shown that it was effective in preventing the occurrence of HE in RCT. The aim was to assess the benefits of sodium PB in cirrhotic patients admitted in ICU for overt HE, in terms of ammonia levels decrease, neurological improvement and survival. Cirrhotic patients who presented with overt HE, ammonia levels >100 μmol/L, and did not display any contra-indication were included...
December 14, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29236348/isolation-of-a-reactive-tricoordinate-alpha-oxo-gold-carbene-complex
#9
Abdallah Zeineddine, Feriel Rekhroukh, E Daiann Sosa Carrizo, Sonia Mallet-Ladeira, Karinne Miqueu, Abderrahmane Amgoune, Didier Bourissou
The [(P,P)Au=C(Ph)CO2Et]+ complex 3 [where (P,P) is an o-carboranyl diphosphine ligand] was prepared by diazo decomposition at -40°C. It is the first alpha-oxo gold carbene complex to be characterized. Its crystallographic structure was determined and DFT calculations have been performed, unraveling the key influence of the chelating (P,P) ligand. The gold center is tricoordinate and the electrophilicity of the carbene center is reduced. Complex 3 mimics transient alpha-oxo gold carbenes in a series of catalytic transformations, and enables to support the critical role of electrophilicity in the chemoselectivity of phenol functionalization (O-H vs C-H insertion)...
December 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29227154/pose-determination-of-a-blade-implant-in-three-dimensions-from-a-single-two-dimensional-radiograph
#10
Toti Paolo, Barone Antonio, Marconcini Simone, Menchini-Fabris Giovanni Battista, Martuscelli Ranieri, Covani Ugo
OBJECTIVES: The aim of the study was to introduce a mathematical method to estimate the correct pose of a blade by evaluating the radiographic features obtained from a single two-dimensional image. METHODS: Blade-form implant bed preparation was performed using the piezosurgery device, and placement was attained with the use of magnetic mallet. The pose determination of the blade was described by means of three consecutive rotations defined by three angles of orientation (triplet φ, θ and Ψ)...
December 11, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29225582/significant-need-for-a-french-network-of-expert-centers-enabling-a-better-characterization-and-management-of-treatment-resistant-depression-fondation-fondamental
#11
Antoine Yrondi, Djamila Bennabi, Emmanuel Haffen, Marion Garnier, Frank Bellivier, Thierry Bourgerol, Vincent Camus, Thierry D'Amato, Olivier Doumy, Frédéric Haesebaert, Jérôme Holtzmann, Christophe Lançon, Philippe Vignaud, Fanny Moliere, Isabel Nieto, Raphaëlle Marie Richieri, Philippe Domenech, Corentin Rabu, Luc Mallet, Liova Yon, Laurent Schmitt, Florian Stephan, Guillaume Vaiva, Michel Walter, Pierre-Michel Llorca, Philippe Courtet, Marion Leboyer, Wissam El-Hage, Bruno Aouizerate
Background: Major depression is characterized by (i) a high lifetime prevalence of 16-17% in the general population; (ii) a high frequency of treatment resistance in around 20-30% of cases; (iii) a recurrent or chronic course; (iv) a negative impact on the general functioning and quality of life; and (v) a high level of comorbidity with various psychiatric and non-psychiatric disorders, high occurrence of completed suicide, significant burden along with the personal, societal, and economic costs...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29223630/postoperative-loss-of-midline-function-in-brachial-plexus-birth-palsy
#12
Dustin A Greenhill, Arianna Trionfo, Frederick V Ramsey, Scott H Kozin, Dan A Zlotolow
PURPOSE: To identify the rate of and predictive variables for functionally limited shoulder internal rotation in postoperative patients with brachial plexus birth palsy. METHODS: Records of patients with brachial plexus birth palsy who had surgery on the affected upper extremity during a 10-year period were retrospectively reviewed. Patient demographics, physical examinations, and all upper extremity procedures were recorded. Loss of midline function (LOM) was defined as a Modified Mallet Scale or Active Movement Scale (AMS) internal rotation score <3...
December 6, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29215203/analysis-of-ketamine-and-xylazine-in-complex-matrices-using-two-dimensional-2d-lc-ms-ms
#13
Malorie Mella, Brenda Schweitzer, Sabra Botch-Jones, Claude Mallet
RATIONALE: Analyzing tissue samples is routinely performed when liquid biological samples are not available for replicate analysis. Preparing complex matrices, such as tissue, for analysis can be time-consuming. Traditional sample preparation methods typically begin with homogenization followed by a sample clean up step such as liquid-liquid or solid phase extraction. Samples are typically eluted, evaporated and reconstituted prior to instrumental analysis. The aim of this project was to evaluate multi-dimensional chromatography's utility in reducing the amount of time from sample acquisition to analysis...
December 7, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29199193/effect-of-virtual-reality-versus-conventional-physiotherapy-on-upper-extremity-function-in-children-with-obstetric-brachial-plexus-injury
#14
S El-Shamy, R Alsharif
OBJECTIVES: The objective was to evaluate the effects of virtual reality versus conventional physiotherapy on upper extremity function in children with obstetric brachial plexus injury. METHODS: Forty children with Erb's palsy were selected for this randomized controlled study. They were assigned randomly to either group A (conventional physiotherapy program) or group B (virtual reality program using Armeo® spring for 45 min three times/week for 12 successive weeks)...
December 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/29195452/evaluation-and-calibration-of-mobile-phones-for-noise-monitoring-application
#15
Raphaël Ventura, Vivien Mallet, Valérie Issarny, Pierre-Guillaume Raverdy, Fadwa Rebhi
The increasing number and quality of sensors integrated in mobile phones have paved the way for sensing schemes driven by city dwellers. The sensing quality can drastically depend on the mobile phone, and appropriate calibration strategies are needed. This paper evaluates the quality of noise measurements acquired by a variety of Android phones. The Ambiciti application was developed so as to acquire a larger control over the acquisition process. Pink and narrowband noises were used to evaluate the phones' accuracy at levels ranging from background noise to 90 dB(A) inside the lab...
November 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29194671/chronic-hepatitis-e-in-patients-with-indolent-lymphoma-after-treatment-with-rituximab-and-bendamustine
#16
Khaled Alnuaimi, Julie Lavolé, Caroline Lascoux-Combes, Anne-Marie Roque Afonso, Philippe Sogni, Stanislas Pol, Vincent Mallet
No abstract text is available yet for this article.
December 1, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29181839/abdominal-computed-tomography-angiography-in-post-transplantation-sinusoidal-obstruction-syndrome-associated-with-r-dhaox-beam-toxicity
#17
Julie Lavolé, Marielle Le Goff, Amar Oudjit, Philippe Sogni, Vincent Mallet
No abstract text is available yet for this article.
November 27, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29176894/horizontal-acquisition-of-a-hypoxia-responsive-molybdenum-cofactor-biosynthesis-pathway-contributed-to-mycobacterium-tuberculosis-pathoadaptation
#18
Florence Levillain, Yannick Poquet, Ludovic Mallet, Serge Mazères, Michael Marceau, Roland Brosch, Franz-Christoph Bange, Philip Supply, Axel Magalon, Olivier Neyrolles
The unique ability of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, to persist for long periods of time in lung hypoxic lesions chiefly contributes to the global burden of latent TB. We and others previously reported that the M. tuberculosis ancestor underwent massive episodes of horizontal gene transfer (HGT), mostly from environmental species. Here, we sought to explore whether such ancient HGT played a part in M. tuberculosis evolution towards pathogenicity. We were interested by a HGT-acquired M...
November 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29174111/-pseudomonas-aeruginosa-in-post-piercing-perichondritis-two-case-reports
#19
A-G Lelong, S Mallet, C Le Treut, J-C Dubus, A Carsin, E Bosdure
The frequency of body piercing has increased in France over the past few years, particularly among teenagers. Piercing can be performed at different sites on the body, especially in the cartilage of the ears. We relate two cases of Pseudomonas aeruginosa chondritis. A 10-year retrospective study at the Marseille University Hospital found no additional pediatric cases. These infectious complications can sometimes be necrotizing. It is therefore important to inform the medical staff on the hygiene measures that need to be respected and the patients on the treatment to follow after the piercing as well as the signs to watch for, possibly indicating chondritis...
November 22, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29174096/surgical-and-nonsurgical-management-of-mallet-finger-a-systematic-review
#20
James S Lin, Julie Balch Samora
PURPOSE: The current literature describes multiple surgical and nonsurgical techniques for the management of mallet finger injuries, and there is no consensus on the indications for surgical treatment. The objective of this study was to determine, through a literature review, if any conclusions can be drawn concerning the indications for surgery in mallet finger injuries; the treatment outcomes of surgical versus nonsurgical management; the most effective methods of surgical and nonsurgical treatment; and the most common treatment complications of mallet finger injuries...
November 22, 2017: Journal of Hand Surgery
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