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https://www.readbyqxmd.com/read/28637232/phyloligo-a-package-to-identify-contaminant-or-untargeted-organism-sequences-in-genome-assemblies
#1
Ludovic Mallet, Tristan Bitard-Feildel, Franck Cerutti, Hélène Chiapello
Motivation: Genome sequencing projects sometimes uncover more organisms than expected, especially for complex and/or non-model organisms. It is therefore useful to develop software to identify mix of organisms from genome sequence assemblies. Here we present PhylOligo, a new package including tools to explore, identify and extract organism-specific sequences in a genome assembly using the analysis of their DNA compositional characteristics. Availability: The tools are written in Python3 and R under the GPLv3 Licence and can be found at https://github...
June 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28629519/erythropoietin-endogenous-protection-of-ischemic-brain
#2
Robert T Mallet, Myoung-Gwi Ryou
The human brain requires uninterrupted delivery of blood-borne oxygen and nutrients to sustain its function. Focal ischemia, particularly, ischemic stroke, and global ischemia imposed by cardiac arrest disrupt the brain's fuel supply. The resultant ATP depletion initiates a complex injury cascade encompassing intracellular Ca(2+) overload, glutamate excitotoxicity, oxido-nitrosative stress, extracellular matrix degradation, and inflammation, culminating in neuronal and astroglial necrosis and apoptosis, neurocognitive deficits, and even death...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28624305/durability-of-immunogenicity-and-strain-coverage-of-menbvac-a-meningococcal-vaccine-based-on-outer-membrane-vesicles-lessons-of-the-normandy-campaign
#3
Julien Sevestre, Eva Hong, Valérie Delbos, Aude Terrade, Eric Mallet, Ala-Eddine Deghmane, Ludovic Lemée, Muhamed-Kheir Taha, François Caron
OBJECTIVES: MenBvac® is an outer membrane vesicle (OMV)-based meningococcal vaccine. From 2006 to 2012, it was used to control a clonal B outbreak in Normandy (France). We aimed to analyse the durability of the response against the epidemic strain and coverage beyond the vaccine strain. These data should help to optimize the use of OMV-containing vaccines, such as the new 4CMenB/Bexsero® recombinant vaccine. METHODS: Serum bactericidal activity (SBA) was measured in two cohorts of children who received their first dose of MenBvac® at 1-5years of age and accepted to provide a blood sample either one or four years after a 2+1+1 schedule...
June 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28608478/dental-extraction-from-an-appendix-a-case-report-and-review-of-the-literature
#4
Aaron Smith, Omar Mouline, Tony Mallet, Gael Phillips, Merwe Hartslief
No abstract text is available yet for this article.
June 12, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28604550/the-versatile-hook-plate-in-avulsion-fractures-of-the-hand
#5
Andal Thirumalai, Petros Mikalef, Rajive Mathew Jose
Avulsion fractures can pose technical difficulties for surgical fixation. The fragments are often small and around finger joints with access being difficult due to attachment of ligaments or tendons. Traditionally, these have been treated using K wires, lag screws, or pullout sutures.Hook plates were originally described for operative management of mallet fractures. We have been using hook plates in our unit for over 10 years. However, over the years, we have extended their use to other avulsion fractures in the hand such as proximal interphalangeal joint fracture dislocations, central slip avulsions, flexor digitorum profundus avulsions and collateral ligament avulsions...
June 9, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28591255/entomological-survey-in-the-state-of-piau%C3%A3-northeastern-brazil-reveals-intradomiciliary-colonization-of-triatoma-brasiliensis-macromelasoma
#6
Silvia Menezes Dos Santos, Danielle Misael de Sousa, Jessica Pereira Dos Santos, José Felipe Pinheiro do Nascimento Vieira, Teresa Cristina Monte Gonçalves, Jacenir Reis Dos Santos-Mallet, Filipe Anibal Carvalho-Costa
This survey aimed to assess the presence of triatomine vectors of Chagas disease within the rural communities of São João do Piauí, Northeast Brazil. Intradomiciliary and peridomiciliary collection strategies were implemented wherein 279 specimens of Triatoma brasiliensis macromelasoma, both nymph and adult were found in 15 (50%) of the studied homes. Of the intradomiciliary insects, 73 (67.6%) were identified as nymph instars (1st instar [N1]= 6, N2= 14, N3= 28, N4= 7 and N5= 18). In the studied communities, a continuous interaction between triatomine bugs and humans could be shown...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28586532/periodontal-status-and-serum-biomarker-levels-in-hfe-hemochromatosis-patients-a-case-series-study
#7
Vincent Meuric, Fabrice Lainé, Emile Boyer, Sandrine Le Gall-David, Emmanuel Oger, Denis Bourgeois, Philippe Bouchard, Edouard Bardou-Jacquet, Valérie Turmel, Martine Bonnaure-Mallet, Yves Deugnier
AIM: To investigate the association between periodontal status and serum biomarkers in patients with HFE hemochromatosis. MATERIAL AND METHODS: This clinical case series included 84 HFE-C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated...
June 6, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28574999/predictors-of-renal-function-recovery-among-patients-undergoing-renal-replacement-therapy-following-orthotopic-liver-transplantation
#8
Maria Claudia Cruz Andreoli, Nádia Karina Guimarães de Souza, Adriano Luiz Ammirati, Thais Nemoto Matsui, Fabiana Dias Carneiro, Ana Claudia Mallet de Souza Ramos, Ilson Jorge Iizuca, Maria Paula Vilela Coelho, Rogério Carballo Afonso, Ben-Hur Ferraz-Neto, Marcio Dias de Almeida, Marcelino Durão, Marcelo Costa Batista, Julio Cesar Monte, Virgílio Gonçalves Pereira, Oscar Pavão Dos Santos, Bento Cardoso Dos Santos
Renal dysfunction frequently occurs during the periods preceding and following orthotopic liver transplantation (OLT), and in many cases, renal replacement therapy (RRT) is required. Information regarding the duration of RRT and the rate of kidney function recovery after OLT is crucial for transplant program management. We evaluated a sample of 155 stable patients undergoing post-intensive care hemodialysis (HD) from a patient population of 908 adults who underwent OLT. We investigated the average time to renal function recovery (duration of RRT required) and determined the risk factors for remaining on dialysis > 90 days after OLT...
2017: PloS One
https://www.readbyqxmd.com/read/28569143/spondylodiscitis-in-a-healthy-12-year-old-girl-with-extraintestinal-pathogenic-escherichia-coli-expec-bacteraemia
#9
J Gaschignard, G Geslain, C Mallet, M Lorrot, N Blot, M Alison, S Bonacorsi
BACKGROUND: Escherichia coli (E. coli) is rarely implicated in bone or joint infections in children. CASE PRESENTATION: We discuss the case of a healthy 12-year-old girl with an E. coli bacteraemia and a T11-T12 spondylodiscitis revealed by magnetic resonance imaging. The strain harboured serogroup O1:K1 and virulence factors common to highly virulent extra intestinal pathogenic E. coli (ExPEC). Immunological work-up was normal. CONCLUSION: The identification of E...
May 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28539421/sound-making-actions-lead-to-immediate-plastic-changes-of-neuromagnetic-evoked-responses-and-induced-%C3%AE-band-oscillations-during-perception
#10
Bernhard Ross, Masihullah Barat, Takako Fujioka
Auditory and sensorimotor brain areas interact during the action-perception cycle of sound making. Neurophysiological evidence of a feedforward model of the action and its outcome has been associated with attenuation of the N1 wave of auditory evoked responses elicited by self-generated sounds, such as talking and singing or playing a musical instrument. Moreover, neural oscillations at β-band frequencies have been related to predicting the sound outcome after action initiation. We hypothesized that a newly learned action-perception association would immediately modify interpretation of the sound during subsequent listening...
June 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28523290/complex-modular-architecture-around-a-simple-toolkit-of-wing-pattern-genes
#11
Steven M Van Belleghem, Pasi Rastas, Alexie Papanicolaou, Simon H Martin, Carlos F Arias, Megan A Supple, Joseph J Hanly, James Mallet, James J Lewis, Heather M Hines, Mayte Ruiz, Camilo Salazar, Mauricio Linares, Gilson R P Moreira, Chris D Jiggins, Brian A Counterman, W Owen McMillan, Riccardo Papa
Identifying the genomic changes that control morphological variation and understanding how they generate diversity is a major goal of evolutionary biology. In Heliconius butterflies, a small number of genes control the development of diverse wing color patterns. Here, we used full genome sequencing of individuals across the Heliconius erato radiation and closely related species to characterize genomic variation associated with wing pattern diversity. We show that variation around color pattern genes is highly modular, with narrow genomic intervals associated with specific differences in color and pattern...
2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28511813/conservative-management-of-mallet-injuries-a-national-survey-of-current-practice-in-the-uk
#12
Z Tolkien, S Potter, N Burr, M D Gardiner, J M Blazeby, A Jain, J Henderson
INTRODUCTION: Mallet injuries are common and usually treated conservatively. Various systematic reviews have found a lack of evidence regarding the best management, and it is unclear whether this uncertainty is reflected in current UK practice. METHODS: An online survey was developed to determine the current practice for the conservative treatment of mallet injury among specialist hand clinicians in the UK, including physiotherapists, occupational therapists and surgeons...
April 23, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28506179/value-of-soft-tissue-release-procedure-around-the-shoulder-to-improve-shoulder-abduction-in-birth-brachial-plexus-palsy-and-analysis-of-the-factors-affecting-outcome
#13
S Raja Sabapathy, Praveen Bhardwaj, Hari Venkatramani
BACKGROUND: A lack of shoulder abduction in spontaneously recovered birth brachial plexus palsy (BBPP) is a common presentation. We have performed a soft tissue release operation in these patients to remove the tethering effect of the tight and cocontracting shoulder adductors. This study was undertaken in order to assess the outcome of this surgical procedure. METHODS: We performed a retrospective analysis of 120 patients who displayed spontaneous recovery from BBPP and subsequently underwent soft tissue release procedure to improve shoulder abduction...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28499640/-what-is-the-place-for-biomarkers-during-acute-copd-exacerbations
#14
Y-E Claessens, N Weiss, T Riqué, T Mallet-Coste
No abstract text is available yet for this article.
May 9, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28492398/chronic-hepatitis-e-in-hiv-hbv-coinfected-patient-lack-of-power-of-sofosbuvir-ribavirin
#15
Eve Todesco, Sophie Demeret, Ruxandra Calin, Anne-Marie Roque-Afonso, Vincent Thibault, Vincent Mallet, Sepideh Akhavan, Marie Jaspard, Gilles Peytavin, Thierry Poynard, Christine Katlama, Valérie Pourcher
No abstract text is available yet for this article.
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28490448/intermittent-hypoxia-training-blunts-cerebrocortical-presenilin-1-overexpression-and-amyloid-%C3%AE-accumulation-in-ethanol-withdrawn-rats
#16
Myoung-Gwi Ryou, Robert T Mallet, Daniel B Metzger, Marianna E Jung
Abrupt cessation of chronic alcohol consumption triggers signaling cascades that harm vulnerable brain regions and produce neurobehavioral deficits. We have demonstrated that a program of intermittent, normobaric hypoxia training (IHT) in rats prevents neurobehavioral impairment resulting from abrupt ethanol withdrawal (EW). Moreover, EW induced expression of stress-activated protein kinase p38 and presenilin 1 (PS1), the γ-secretase component that produces the neurotoxic amyloid-β (Aβ) peptides, Aβ40 and Aβ42...
May 10, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28489447/patient-initiated-splintage-of-a-mallet-finger-injury-avoids-unnecessary-complications
#17
Rohan Prakash, Edward Ong, Dominic Brown, Alistair Hunter
No abstract text is available yet for this article.
May 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28476771/signature-of-microbial-dysbiosis-in-periodontitis
#18
Vincent Meuric, Sandrine Le Gall-David, Emile Boyer, Luis Acuña-Amador, Bénédicte Martin, Shao Bing Fong, Frederique Barloy-Hubler, Martine Bonnaure-Mallet
Periodontitis is driven by a disproportionate host inflammatory immune response induced by an imbalance in the composition of oral bacteria. It instigates microbial dysbiosis along with failed resolution of the chronic destructive inflammation.The objective of this study is to identify microbial signatures for health and chronic periodontitis at the genus level and to propose a model of dysbiosis including the calculation of bacterial ratios. DESIGN AND METHODS: Published sequencing data obtained from several different studies (196 sub-gingival samples from patients with chronic periodontitis and 422 sub-gingival samples from healthy subjects) were pooled and submitted to a new microbiota analysis using the same VAMPS (Visualization and Analysis of Microbial Population Structures) analysis pipeline to identify microbiota specific to health and disease...
May 5, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28476259/levocetirizine-and-prednisone-are-not-superior-to-levocetirizine-alone-for-the-treatment-of-acute-urticaria-a-randomized-double-blind-clinical%C3%A2-trial
#19
Caroline Barniol, Emilie Dehours, Jean Mallet, Charles-Henri Houze-Cerfon, Dominique Lauque, Sandrine Charpentier
STUDY OBJECTIVE: We evaluate the efficacy of a 4-day course of prednisone added to antihistamine for the management of acute urticaria in an emergency department (ED). METHODS: In this double-blind randomized clinical trial, patients were eligible for inclusion if aged 18 years or older and with acute urticaria of no more than 24 hours' duration. Patients with anaphylaxis or who had received antihistamines or glucocorticoids during the previous 5 days were not included...
May 2, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28476014/advanced-paternal-age-is-associated-with-earlier-schizophrenia-onset-in-offspring-results-from-the-national-multicentric-face-sz-cohort
#20
Guillaume Fond, Ophélia Godin, Laurent Boyer, Pierre-Michel Llorca, Meja Andrianarisoa, Lore Brunel, Bruno Aouizerate, Fabrice Berna, Delphine Capdevielle, Thierry D'Amato, Hélène Denizot, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Franck Gabayet, Jasmina Mallet, David Misdrahi, Christine Passerieux, Romain Rey, Raphaelle Richieri, Aurélie Schandrin, Mathieu Urbach, Pierre Vidailhet, Marion Leboyer, Ewa Bulzacka, Franck Schürhoff, Meja Andrianarisoa, Bruno Aouizerate, Fabrice Berna, Olivier Blanc, Lore Brunel, Ewa Bulzacka, Delphine Capdevielle, Isabelle Chereau-Boudet, Géraldine Chesnoy-Servanin, Jean-Michel Danion, Thierry D'Amato, Arnaud Deloge, Céline Delorme, Hélène Denizot, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Cécile Fluttaz, Guillaume Fond, Sophie Fonteneau, Franck Gabayet, Elisabeth Giraud-Baro, Marie-Christine Hardy-Bayle, Lacelle Delphine, Christophe Lançon, Hakim Laouamri, Marion Leboyer, Tifenn Le Gloahec, Yann Le Strat, Pierre-Michel Llorca, Jasmina Mallet, Emeline Metairie, David Misdrahi, Isabelle Offerlin-Meyer, Christine Passerieux, Pauline Peri, Sylvie Pires, Céline Portalier, Romain Rey, Céline Roman, Aurélie Schandrin, Franck Schürhoff, Arnaud Tessier, Anne-Marie Tronche, Mathieu Urbach, Florence Vaillant, Aurélie Vehier, Pierre Vidailhet, Estel Vilà, Hanan Yazbek, Anna Zinetti-Bertschy
The association between advanced paternal age (APA) and increased risk of schizophrenia (SZ) is well established. The objectives of the present study were to further determine if SZ participants with APA (APA+), versus those without (APA-), had: (i) different illness characteristics; (ii) different responses to antipsychotic medication; and (iii) different cognitive characteristics. Participants were a non-selected representative multicentric sample of stabilized community-dwelling people diagnosed with SZ included in the FACE-SZ cohort...
April 12, 2017: Psychiatry Research
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