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Didier Musso, Hervé Bossin, Henri Pierre Mallet, Marianne Besnard, Julien Broult, Laure Baudouin, José Eduardo Levi, Ester C Sabino, Frederic Ghawche, Marion C Lanteri, David Baud
The Zika virus crisis exemplified the risk associated with emerging pathogens and was a reminder that preparedness for the worst-case scenario, although challenging, is needed. Herein, we review all data reported during the unexpected emergence of Zika virus in French Polynesia in late 2013. We focus on the new findings reported during this outbreak, especially the first description of severe neurological complications in adults and the retrospective description of CNS malformations in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission, mother-to-child transmission, and the development of new diagnostic assays...
November 14, 2017: Lancet Infectious Diseases
S Szepetowski, C Lacoste, S Mallet, B Roquelaure, C Badens, A Fabre
NISCH syndrome is a rare autosomal recessive disease. It is characterized by scalp hypotrichosis, scarring alopecia, ichthyosis, and neonatal sclerosing cholangitis. It is caused by mutations in the CLDN1 gene encoding the claudin-1 protein, which is located at tight junctions. Fifteen cases have been reported to date and three different mutations have been identified. We report on the case of a 2-year-old boy from a consanguineous Moroccan family, presenting with NISCH syndrome and carrying the so-called Moroccan homozygous mutation (c...
November 13, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Franck Cerutti, Ludovic Mallet, Anaïs Painset, Claire Hoede, Annick Moisan, Christophe Bécavin, Mélodie Duval, Olivier Dussurget, Pascale Cossart, Christine Gaspin, Hélène Chiapello
BACKGROUND: Small regulatory RNAs (sRNAs) are widely found in bacteria and play key roles in many important physiological and adaptation processes. Studying their evolution and screening for events of coevolution with other genomic features is a powerful way to better understand their origin and assess a common functional or adaptive relationship between them. However, evolution and coevolution of sRNAs with coding genes have been sparsely investigated in bacterial pathogens. RESULTS: We designed a robust and generic phylogenomics approach that detects correlated evolution between sRNAs and protein-coding genes using their observed and inferred patterns of presence-absence in a set of annotated genomes...
November 16, 2017: BMC Genomics
Patricia Bove, Dominique Claveau-Mallet, Étienne Boutet, Félix Lida, Yves Comeau
The main objective of this project was to develop a steel slag filter effluent neutralization process by acidification with CO2-enriched air coming from a bioprocess. Sub-objectives were to evaluate the neutralization capacity of different configurations of neutralization units in lab-scale conditions and to propose a design model of steel slag effluent neutralization. Two lab-scale column neutralization units fed with two different types of influent were operated at hydraulic retention time of 10 h. Tested variables were mode of flow (saturated or percolating), type of media (none, gravel, Bionest and AnoxKaldnes K3), type of air (ambient or CO2-enriched) and airflow rate...
November 3, 2017: Water Research
G Fond, N Resseguier, F Schürhoff, O Godin, M Andrianarisoa, L Brunel, E Bulzacka, B Aouizerate, F Berna, D Capdevielle, I Chereau, T D'Amato, C Dubertret, J Dubreucq, C Faget, F Gabayet, C Lançon, P M Llorca, J Mallet, D Misdrahi, C Passerieux, R Rey, A Schandrin, M Urbach, P Vidailhet, L Boyer, M Leboyer
Low-grade inflammation has repeatedly been associated with schizophrenia (SZ) and in particular with cognitive impairment. Female gender, overweight and tobacco smoking have been suggested as risk factors to increase inflammation while preclinical inconsistent findings have been found regarding the association with psychotropic drugs. The aim of this study was to explore if psychotropic drugs were associated with inflammation in SZ and to determine which psychotropic drug was associated with inflammation in stable SZ subjects while considering clinical confounding factors...
November 10, 2017: European Archives of Psychiatry and Clinical Neuroscience
Louis Rony, Pierre de Sainte Hermine, Vincent Steiger, Romain Mallet, Laurent Hubert, Daniel Chappard
We analyzed by SEM three alumina-on-alumina femoral heads obtained from three patients who underwent revision for an aseptic loosening of the acetabular component. In parallel, the peri-prosthetic tissues were analyzed histologically in search of wear debris coming from the ceramic. Stripe wears, abrasive streaks, craters, and areas with extensive biomaterial removal were evidenced on the three femoral heads by SEM. In the altered area, the structure of the ceramic composed of minute polyhedric grains packed together was evidenced...
November 4, 2017: Micron: the International Research and Review Journal for Microscopy
Joyce Tie, Michael K H Hsieh, Shian Chao Tay
BACKGROUND: Hook plate fixation of closed mallet fractures was first described in 2007, but there has subsequently been a lack of studies examining the outcomes and complications of this technique. METHODS: This paper aims to assess the clinical outcomes of hook plate fixation of closed mallet fractures by retrospectively reviewing 31 closed, bony mallet injuries that were surgically fixed with a hook plate between 2002-2011. RESULTS: Patients who underwent hook plate fixation had a median time to radiographic union of 83 days...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
Sylvain G Dutremez, Alysson Duarte Rodrigues, Karim Fahsi, Xavier Dumail, Nathalie Masquelez, Arie van der Lee, Sonia Mallet-Ladeira, Romain Sibille, Jean-Sébastien Filhol
Solvothermal reaction in N,N-dimethylformamide (DMF) between 1,6-bis(1-imidazolyl)-2,4-hexadiyne monohydrate (L1·H2O), isophthalic acid (H2L2), and Zn(NO3)2·6 H2O gives the diacetylene-based mixed-ligand coordination polymer {[Zn(L1)(L2)](DMF)2}n (UMON-44) in 38% yield. Combination of DSC with variable-temperature single-crystal X-ray diffraction revealed the occurrence of two phase transitions spanning the ranges 129-144 K and 158-188 K. Furthermore, the three structurally similar phases of UMON-44 show giant negative and/or colossal positive thermal expansions...
November 8, 2017: Chemistry: a European Journal
Bruno E Crepaldi, José Queiroz L Neto, Marcelo R Rezende, Rames M Júnior, Daniele S Scarcella
BACKGROUND: Brachial plexus injury is a complex entity that often results in partial recovery. Most studies to date have focused on improving shoulder abduction. However, a recent technique has been outlined-one that transfers the lower trapezius to improve the external rotation of the shoulder. The primary objective of this study was to evaluate the gains in external rotation of the shoulder in patients who have undergone transfer of the lower trapezius; secondarily, we assessed the range of motion in the elbow and shoulder joints, as well as the muscle strength and quality of life...
November 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
J Mallet, S Lancrenon, P-M Llorca, C Lançon, F-J Baylé, P Gorwood
OBJECTIVES: We previously developed the Functional Remission Of General Schizophrenia (FROGS) scale demonstrating first, reliable assessment in a cross-sectional study and second, good time-stability. The purpose of the present analysis was to propose a shorter version (mini-FROGS), more compatible with the limited time available in a psychiatric visit, focusing on the functional domains that have higher likelihood of being improved with higher and/or longer symptomatic remission in different cultural backgrounds...
September 22, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
C F Mello, J R Santos-Mallet, A Tátila-Ferreira, J Alencar
Characterising the external morphology of mosquito eggs is important, since it facilitates the identification of material from breeding sites and contributes to the understanding of species biology and group systematics. Therefore, was to compare eggs from different Psorophora ferox populations using scanning electron microscopy (SEM). Eggs were obtained from adult female of Ps. ferox collected in the Poços das Antas Biological Reserve (Reserva Biológica de Poços das Antas, Rio de Janeiro, Brazil). From each female, one portion of eggs (n = 5) was reared for identification purposes, and the second portion (n = 10) was examined using SEM for morphometric analysis...
October 30, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
Lorenzo Subissi, Elise Daudens-Vaysse, Sylvie Cassadou, Martine Ledrans, Priscillia Bompard, Joël Gustave, Maité Aubry, Van-Mai Cao-Lormeau, Henri-Pierre Mallet
French Polynesia and French Territories of the Americas (FTAs) have experienced outbreaks of Zika virus (ZIKV) infection. These territories used similar sentinel syndromic surveillance to follow the epidemics. However, the surveillance system only takes into account consulting patients diagnosed with ZIKV disease, while non-consulting cases as well as asymptomatic cases are not taken into account. In the French territories under study, we report the ratio of consulting versus non-consulting patients to likely be as low as 1/3 to 1/4 and rough estimates of the ZIKV asymptomatic infections pointing at a lower rate than previously reported (i...
October 25, 2017: International Journal of Infectious Diseases: IJID
Xiaoli Liu, Diqun Xu, James R Hall, Sarah Ross, Shande Chen, Howe Liu, Robert T Mallet, Xiangrong Shi
Cerebral vasodilation and increased cerebral oxygen extraction help maintain cerebral oxygen uptake in the face of hypoxemia. This study examined cerebrovascular responses to intermittent hypoxemia in eight healthy men breathing 10% O2 for 5 cycles, each 6 min, interspersed with 4 min of room air breathing. Hypoxia exposures raised heart rate (P<0.01) without altering arterial pressure, and increased ventilation (P<0.01) by expanding tidal volume. Arterial oxygen saturation (SaO2) and cerebral tissue oxygenation (ScO2) fell (P<0...
October 26, 2017: Journal of Applied Physiology
Ludovic Martin, Nabil Kaci, Valentin Estibals, Nicolas Goudin, Meriem Garfa-Traore, Catherine Benoist-Lasselin, Emilie Dambroise, Laurence Legeai-Mallet
FGFR3 (fibroblast growth factor receptor 3) gain-of-function mutations cause dwarfisms, including achondroplasia (ACH) and thanatophoric dysplasia (TD). The constitutive activation of FGFR3 disrupts the normal process of skeletal growth. Bone-growth anomalies have been identified in skeletal ciliopathies, in which primary cilia (PC) function is disrupted. In human ACH and TD, the impact of FGFR3 mutations on PC in growth plate cartilage remains unknown. Here we showed that in chondrocytes from human (ACH, TD) and mouse Fgfr3Y367C/+ cartilage, the constitutively-active FGFR3 perturbed PC length and the sorting and trafficking of IFT20 to the PC...
October 4, 2017: Human Molecular Genetics
Amin Mirzaei, Arvind Kumar, Daniel Leventhal, Nicolas Mallet, Ad Aertsen, Joshua Berke, Robert Schmidt
Brief epochs of beta oscillations have been implicated in sensorimotor control in the basal ganglia of task-performing healthy animals. However, which neural processes underlie their generation and how they are affected by sensorimotor processing remains unclear. To determine the mechanisms underlying transient beta oscillations in the local field potential (LFP), we combined computational modeling of the subthalamo-pallidal network for the generation of beta oscillations with realistic stimulation patterns derived from single unit data...
October 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
S K Lee, Y H Kim, K H Moon, W S Choy
INTRODUCTION: Extension-block pinning represents a simple and reliable surgical technique. Although this procedure is commonly performed successfully, some patients develop postoperative extension loss. To date, the relationship between extension-block Kirschner wire (K-wire) insertion angle and postoperative extension loss in mallet finger fracture remains unclear. HYPOTHESIS: We aimed to clarify this relationship and further evaluate how various operative and non-operative factors affect postoperative extension loss after extension-block pinning for mallet finger fracture...
October 9, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
Sudipta Dubey, Simone Lisi, Goutham Nayak, Felix Herziger, Van-Dung Nguyen, Toai Le Quang, Vladimir Cherkez, Cézar González, Yannick J Dappe, Kenji Watanabe, Takashi Taniguchi, Laurence Magaud, Pierre Mallet, Jean-Yves Veuillen, Raul Arenal, Laëtitia Marty, Julien Renard, Nedjma Bendiab, Johann Coraux, Vincent Bouchiat
Few- and single-layer MoS2 host substantial densities of defects. They are thought to influence the doping level, the crystal structure, and the binding of electron-hole pairs. We disentangle the concomitant spectroscopic expression of all three effects, and identify to which extent they are intrinsic to the material or extrinsic to it, i.e. related to its local environment. We do so by using different sources of MoS2 - a natural one and one prepared at high pressure and high temperature - and different substrates bringing varying amounts of charged impurities, and by separating the contributions of internal strain and doping in Raman spectra...
October 9, 2017: ACS Nano
Dominique Claveau-Mallet, Benoît Courcelles, Philippe Pasquier, Yves Comeau
The first version of the P-Hydroslag model for numerical simulations of steel slag filters is presented. This model main original feature is the implementation of slag exhaustion behavior, crystal growth and crystal size effect on crystal solubility, and crystal accumulation effect on slag dissolution. The model includes four mineral phases: calcite, monetite, homogeneous hydroxyapatite (constant size and solubility) and heterogeneous hydroxyapatite (increasing size and decreasing solubility). In the proposed model, slag behavior is represented by CaO dissolution kinetic rate and exhaustion equations; while slag dissolution is limited by a diffusion rate through a crystal layer...
December 1, 2017: Water Research
G Fond, L Boyer, M Leboyer, O Godin, P M Llorca, M Andrianarisoa, F Berna, L Brunel, B Aouizerate, D Capdevielle, I Chereau, T D'Amato, C Dubertret, J Dubreucq, C Faget, F Gabayet, J Mallet, D Misdrahi, R Rey, C Lancon, C Passerieux, P Roux, P Vidailhet, H Yazbek, F Schürhoff, E Bulzacka
OBJECTIVES: Sex differences can yield important clues regarding illness pathophysiology and its treatment. Schizophrenia (SZ) has a lower incidence rate, and a better prognosis, in women versus men. The present study investigated the cognitive profiles of both sexes in a large multi-centre sample of community-dwelling SZ patients. METHOD: 544 community-dwelling stable SZ subjects (141 women and 403 men; mean age 34.5±12.1 and 31.6±8.7years, respectively) were tested with a comprehensive battery of neuropsychological tests...
September 30, 2017: Schizophrenia Research
Karen E Forward, Arjang Yazdani, Rodrick Lim
A mallet finger is a flexion deformity of a finger at the distal interphalangeal joint due to an injury of the extensor mechanism at the base of the distal phalanx. Most common in middle-aged men, injuries in the pediatric population are less common and rare in toddlers. We describe a case of missed mallet finger and its subsequent treatment in a female toddler.
October 2017: Pediatric Emergency Care
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