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https://www.readbyqxmd.com/read/28523290/complex-modular-architecture-around-a-simple-toolkit-of-wing-pattern-genes
#1
Steven M Van Belleghem, Pasi Rastas, Alexie Papanicolaou, Simon H Martin, Carlos F Arias, Megan A Supple, Joseph J Hanly, James Mallet, James J Lewis, Heather M Hines, Mayte Ruiz, Camilo Salazar, Mauricio Linares, Gilson R P Moreira, Chris D Jiggins, Brian A Counterman, W Owen McMillan, Riccardo Papa
Identifying the genomic changes that control morphological variation and understanding how they generate diversity is a major goal of evolutionary biology. In Heliconius butterflies, a small number of genes control the development of diverse wing color patterns. Here, we used full genome sequencing of individuals across the Heliconius erato radiation and closely related species to characterize genomic variation associated with wing pattern diversity. We show that variation around color pattern genes is highly modular, with narrow genomic intervals associated with specific differences in color and pattern...
2017: Nat Ecol Evol
https://www.readbyqxmd.com/read/28511813/conservative-management-of-mallet-injuries-a-national-survey-of-current-practice-in-the-uk
#2
Z Tolkien, S Potter, N Burr, M D Gardiner, J M Blazeby, A Jain, J Henderson
INTRODUCTION: Mallet injuries are common and usually treated conservatively. Various systematic reviews have found a lack of evidence regarding the best management, and it is unclear whether this uncertainty is reflected in current UK practice. METHODS: An online survey was developed to determine the current practice for the conservative treatment of mallet injury among specialist hand clinicians in the UK, including physiotherapists, occupational therapists and surgeons...
April 23, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28506179/value-of-soft-tissue-release-procedure-around-the-shoulder-to-improve-shoulder-abduction-in-birth-brachial-plexus-palsy-and-analysis-of-the-factors-affecting-outcome
#3
S Raja Sabapathy, Praveen Bhardwaj, Hari Venkatramani
BACKGROUND: A lack of shoulder abduction in spontaneously recovered birth brachial plexus palsy (BBPP) is a common presentation. We have performed a soft tissue release operation in these patients to remove the tethering effect of the tight and cocontracting shoulder adductors. This study was undertaken in order to assess the outcome of this surgical procedure. METHODS: We performed a retrospective analysis of 120 patients who displayed spontaneous recovery from BBPP and subsequently underwent soft tissue release procedure to improve shoulder abduction...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28499640/-what-is-the-place-for-biomarkers-during-acute-copd-exacerbations
#4
Y-E Claessens, N Weiss, T Riqué, T Mallet-Coste
No abstract text is available yet for this article.
May 9, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28492398/chronic-hepatitis-e-in-hiv-hbv-coinfected-patient-lack-of-power-of-sofosbuvir-ribavirin
#5
Eve Todesco, Sophie Demeret, Ruxandra Calin, Anne-Marie Roque-Afonso, Vincent Thibault, Vincent Mallet, Sepideh Akhavan, Marie Jaspard, Gilles Peytavin, Thierry Poynard, Christine Katlama, Valérie Pourcher
No abstract text is available yet for this article.
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28490448/intermittent-hypoxia-training-blunts-cerebrocortical-presenilin-1-overexpression-and-amyloid-%C3%AE-accumulation-in-ethanol-withdrawn-rats
#6
Myoung-Gwi Ryou, Robert T Mallet, Daniel B Metzger, Marianna E Jung
Abrupt cessation of chronic alcohol consumption triggers signaling cascades that harm vulnerable brain regions and produce neurobehavioral deficits. We have demonstrated that a program of intermittent, normobaric hypoxia training (IHT) in rats prevents neurobehavioral impairment resulting from abrupt ethanol withdrawal (EW). Moreover, EW induced expression of stress-activated protein kinase p38 and presenilin 1 (PS1), the γ-secretase component that produces the neurotoxic amyloid-β (Aβ) peptides, Aβ40 and Aβ42...
May 10, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28489447/patient-initiated-splintage-of-a-mallet-finger-injury-avoids-unnecessary-complications
#7
Rohan Prakash, Edward Ong, Dominic Brown, Alistair Hunter
No abstract text is available yet for this article.
May 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28476771/signature-of-microbial-dysbiosis-in-periodontitis
#8
Vincent Meuric, Sandrine Le Gall-David, Emile Boyer, Luis Acuña-Amador, Bénédicte Martin, Shao Bing Fong, Frederique Barloy-Hubler, Martine Bonnaure-Mallet
Periodontitis is driven by a disproportionate host inflammatory immune response induced by an imbalance in the composition of oral bacteria. It instigates microbial dysbiosis along with failed resolution of the chronic destructive inflammation.The objective of this study is to identify microbial signatures for health and chronic periodontitis at the genus level and to propose a model of dysbiosis including the calculation of bacterial ratios. DESIGN AND METHODS: Published sequencing data obtained from several different studies (196 sub-gingival samples from patients with chronic periodontitis and 422 sub-gingival samples from healthy subjects) were pooled and submitted to a new microbiota analysis using the same VAMPS (Visualization and Analysis of Microbial Population Structures) analysis pipeline to identify microbiota specific to health and disease...
May 5, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28476259/levocetirizine-and-prednisone-are-not-superior-to-levocetirizine-alone-for-the-treatment-of-acute-urticaria-a-randomized-double-blind-clinical%C3%A2-trial
#9
Caroline Barniol, Emilie Dehours, Jean Mallet, Charles-Henri Houze-Cerfon, Dominique Lauque, Sandrine Charpentier
STUDY OBJECTIVE: We evaluate the efficacy of a 4-day course of prednisone added to antihistamine for the management of acute urticaria in an emergency department (ED). METHODS: In this double-blind randomized clinical trial, patients were eligible for inclusion if aged 18 years or older and with acute urticaria of no more than 24 hours' duration. Patients with anaphylaxis or who had received antihistamines or glucocorticoids during the previous 5 days were not included...
May 2, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28476014/advanced-paternal-age-is-associated-with-earlier-schizophrenia-onset-in-offspring-results-from-the-national-multicentric-face-sz-cohort
#10
Guillaume Fond, Ophélia Godin, Laurent Boyer, Pierre-Michel Llorca, Meja Andrianarisoa, Lore Brunel, Bruno Aouizerate, Fabrice Berna, Delphine Capdevielle, Thierry D'Amato, Hélène Denizot, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Franck Gabayet, Jasmina Mallet, David Misdrahi, Christine Passerieux, Romain Rey, Raphaelle Richieri, Aurélie Schandrin, Mathieu Urbach, Pierre Vidailhet, Marion Leboyer, Ewa Bulzacka, Franck Schürhoff, Meja Andrianarisoa, Bruno Aouizerate, Fabrice Berna, Olivier Blanc, Lore Brunel, Ewa Bulzacka, Delphine Capdevielle, Isabelle Chereau-Boudet, Géraldine Chesnoy-Servanin, Jean-Michel Danion, Thierry D'Amato, Arnaud Deloge, Céline Delorme, Hélène Denizot, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Cécile Fluttaz, Guillaume Fond, Sophie Fonteneau, Franck Gabayet, Elisabeth Giraud-Baro, Marie-Christine Hardy-Bayle, Lacelle Delphine, Christophe Lançon, Hakim Laouamri, Marion Leboyer, Tifenn Le Gloahec, Yann Le Strat, Pierre-Michel Llorca, Jasmina Mallet, Emeline Metairie, David Misdrahi, Isabelle Offerlin-Meyer, Christine Passerieux, Pauline Peri, Sylvie Pires, Céline Portalier, Romain Rey, Céline Roman, Aurélie Schandrin, Franck Schürhoff, Arnaud Tessier, Anne-Marie Tronche, Mathieu Urbach, Florence Vaillant, Aurélie Vehier, Pierre Vidailhet, Estel Vilà, Hanan Yazbek, Anna Zinetti-Bertschy
The association between advanced paternal age (APA) and increased risk of schizophrenia (SZ) is well established. The objectives of the present study were to further determine if SZ participants with APA (APA+), versus those without (APA-), had: (i) different illness characteristics; (ii) different responses to antipsychotic medication; and (iii) different cognitive characteristics. Participants were a non-selected representative multicentric sample of stabilized community-dwelling people diagnosed with SZ included in the FACE-SZ cohort...
April 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28472739/inter-joint-coordination-analysis-of-reach-to-grasp-kinematics-in-children-and-adolescents-with-obstetrical-brachial-plexus-palsy
#11
Christian H Mayfield, Sahana N Kukke, Sylvain Brochard, Christopher J Stanley, Katharine E Alter, Diane L Damiano
BACKGROUND: Obstetrical brachial plexus palsy is a common birth injury to nerves passing through the brachial plexus that may result in structural and functional abnormalities. Individual joint trajectories from kinematic analyses have been used to evaluate the source and extent of abnormalities. Here, two summary measures of limb kinematics were utilized: 1) the Arm Profile Score summarizing upper limb joint kinematic abnormalities from a typical pattern across a task, and 2) the recently developed Multi-joint Coordination Measure using principal component analysis to characterize typical coordination of multiple joints throughout a task and compute deviations in time and space...
April 25, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28470031/closed-mallet-thumb-injury-treated-surgically-a-case-report
#12
Michael Arvanitakis, Maurizio Calcagni, Thomas Giesen
In this report a case of closed mallet thumb injury is described, which was diagnosed clinically and indication for surgical treatment was confirmed with ultrasound examination. The EPL-tendon was successfully reconstructed with an excellent result. We propose a mandatory ultrasound examination of all closed mallet thumb injuries.
2017: Case Reports in Plastic Surgery & Hand Surgery
https://www.readbyqxmd.com/read/28465015/complications-of-distal-phalanx-fractures-in-children
#13
Manesha Lankachandra, Corey R Wells, Christine J Cheng, Richard L Hutchison
PURPOSE: To determine whether the incidence of complications varies between among types of distal phalangeal fractures in a pediatric population. METHODS: We retrospectively reviewed the medical records and radiographs of patients seen in the pediatric hand surgery clinic from 2011 to 2012 with a diagnosis of distal phalanx fracture. Patients were identified by International Classification of Diseases-Ninth Revision code (816.02 or 816.12). We reviewed 206 charts and included them in the study...
April 29, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28456668/quantifying-low-frequency-revertants-in-oral-poliovirus-vaccine-using-next-generation-sequencing
#14
Eric Sarcey, Aurélie Serres, Fabrice Tindy, Audrey Chareyre, Siemon Ng, Marine Nicolas, Emmanuelle Vetter, Thierry Bonnevay, Eric Abachin, Laurent Mallet
Spontaneous reversion to neurovirulence of live attenuated oral poliovirus vaccine (OPV) serotype 3 (chiefly involving the n.472U>C mutation), must be monitored during production to ensure vaccine safety and consistency. Mutant analysis by polymerase chain reaction and restriction enzyme cleavage (MAPREC) has long been endorsed by the World Health Organization as the preferred in vitro test for this purpose; however, it requires radiolabeling, which is no longer supported by many laboratories. We evaluated the performance and suitability of next generation sequencing (NGS) as an alternative to MAPREC...
April 26, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28453633/role-of-dna-gyrase-and-topoisomerase-iv-mutations-in-fluoroquinolone-resistance-of-capnocytophaga-spp-clinical-isolates-and-laboratory-mutants
#15
Elodie Ehrmann, Anne Jolivet-Gougeon, Martine Bonnaure-Mallet, Thierry Fosse
Objectives: Capnocytophaga spp. are often reported to cause bacteraemia and extra-oral infections and are characterized by their significant contribution to resistance to β-lactam and macrolide-lincosamide-streptogramin antibiotics in the human oral microbiota. The implication of mutations in the quinolone resistance-determining region (QRDR) of DNA gyrase A and B ( gyrA and gyrB ) and topoisomerase IV ( parC and parE ) of fluoroquinolone (FQ)-resistant Capnocytophaga spp., hitherto unknown, was explored in this study...
April 26, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28453357/the-diagnosis-and-management-of-mallet-finger-injuries
#16
Gregory A Lamaris, Michael K Matthew
BACKGROUND: Mallet finger is a common injury of the extensor tendon insertion causing an extension lag of the distal interphalangeal joint. METHODS: We reviewed the most current literature on the epidemiology, diagnosis, and management of mallet finger injuries focusing on the indications and outcomes of surgical intervention. RESULTS: Nonoperative management has been advocated for almost all mallet finger injuries; however, complex injuries are usually treated surgically...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28453351/mallet-fractures-of-the-thumb-compared-with-mallet-fractures-of-the-fingers
#17
Kamilcan Oflazoglu, Ali Moradi, Yvonne Braun, David Ring, Neal C Chen, Kyle R Eberlin
BACKGROUND: The purpose of this study was to look for differences in mechanism, radiographic findings, and treatment between mallet fractures of the thumb and mallet fractures of the index through small fingers. METHODS: This retrospective study included 24 mallet fractures of the thumb and 392 mallet fractures of other digits. We compared demographics, injury factors (side, dominant hand, time between injury and first visit, and injury mechanism), subluxation, fragment size, treatment, and time from injury to final evaluation between the 2 groups...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28447473/a-midterm-review-of-lesser-toe-arthrodesis-with-an-intramedullary-implant
#18
James Lee Harmer, Anthony Wilkinson, Anthony John Maher
Lesser toe deformities are one of the most common conditions encountered by podiatric surgeons. When conservative treatments fail surgical correction is indicated. Many surgical options have been described to address the complex nature of these deformities but no perfect solution has been reported to date. However, with the continued advancement of internal fixation technology, interphalangeal joint (IPJ) arthrodesis with an intramedullary implant may be a good option. This retrospective study presents patient reported outcomes and complications at 6 months and 3 years following lesser toe proximal interphalangeal joint (PIPJ) arthrodesis with a polyketone intrameduallary implant (Toe Grip, Orthosolutions, UK)...
April 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28442854/biceps-rerouting-after-forearm-osteotomy-an-effective-treatment-strategy-for-severe-supination-deformity-in-obstetric-plexus-palsy
#19
W P Metsaars, M Biegstraaten, R G H H Nelissen
Study Design Retrospective cohort study. Objective Supination deformity in obstetric brachial plexus injury can have debilitating consequences for the functionality of the hand. Surgical treatment by a forearm osteotomy has a recurrence rate of 20 to 42%. As a complement to forearm osteotomy, a biceps rerouting may improve outcome. Methods Children with residual brachial plexus injury, who had a forearm osteotomy for a supination contracture and had a postoperative decrease of pronation to 50 degrees or less, were indicated for a biceps rerouting...
April 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/28442400/laboratory-evaluation-of-brevibacillus-laterosporus-strains-as-biocidal-agents-against-chrysomya-megacephala-fabricius-1794-diptera-calliphoridae-larvae
#20
Isabel Nogueira Carramaschi, Lorrane de Andrade Pereira, Vitor Dos Santos Baia, Jacenir Reis Dos Santos Mallet, Margareth Maria de Carvalho Queiroz, Viviane Zahner
The biocidal activity of three strains of Brevibacillus laterosporus upon the post-embryonic developmental stages of Chrysomya megacephala was evaluated. Bioassays were performed to verify lethal and sub-lethal effects including ultra-structural changes in the midgut. Among the strains assayed, Shi3 presented the highest larval mortality rates, achieving 70% at a concentration of 1×10(8) spores/g of diet. Transmission electron microscopy revealed intestinal alterations caused by all strains tested. The findings of this study indicate that Shi3 represents a promising tool for use in the biocontrol of C...
April 22, 2017: Journal of Invertebrate Pathology
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