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https://www.readbyqxmd.com/read/29790867/fluorine-18-fluorocholine-pet-ct-parameters-predictive-for-hematological-toxicity-to-radium-223-therapy-in-castrate-resistant-prostate-cancer-patients-with-bone-metastases-a-pilot-study
#1
Lavinia Vija Racaru, Mathieu Sinigaglia, Salim Kanoun, Fayçal Ben Bouallègue, Ilan Tal, Sévérine Brillouet, Mathilde Bauriaud-Mallet, Slimane Zerdoud, Lawrence Dierickx, Delphine Vallot, Olivier Caselles, Erwan Gabiache, Pierre Pascal, Frederic Courbon
PURPOSE: This study aims to predict hematological toxicity induced by Ra therapy. We investigated the value of metabolically active bone tumor volume (MBTV) and total bone lesion activity (TLA) calculated on pretreatment fluorine-18-fluorocholine (F-FCH) PET/CT in castrate-resistant prostate cancer (CRPC) patients with bone metastases treated with Ra radionuclide therapy. PATIENTS AND METHODS: F-FCH PET/CT imaging was performed in 15 patients with CRPC before treatment with Ra...
May 21, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29789425/a-heterodimer-formed-by-bone-morphogenetic-protein-9-bmp9-and-bmp10-provides-most-bmp-biological-activity-in-plasma
#2
Emmanuelle Tillet, Marie Ouarné, Agnès Desroches-Castan, Christine Mallet, Mariela Subileau, Robin Didier, Anna Lioutsko, Guillaume Belthier, Jean-Jacques Feige, Sabine Bailly
Bone morphogenetic protein 9 (BMP9) and BMP10 are the two high-affinity ligands for the endothelial receptor activin receptor-like kinase 1 (ALK1) and are key regulators of vascular remodeling. They are both present in the blood, but their respective biological activities are still a matter of debate. The aim of the present work was to characterize their circulating forms to better understand how their activities are regulated in vivo. First, by cotransfecting BMP9 and BMP10, we found that both can form a disulfide-bonded heterodimer in vitro and that this heterodimer is functional on endothelial cells via ALK1...
May 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29780525/cyclometalated-gold-iii-complexes-noticeable-differences-between-n-c-and-p-c-ligands-in-migratory-insertion
#3
Jordi Serra, Pau Font, E Daiann Sosa Carrizo, Sonia Mallet-Ladeira, Stéphane Massou, Teodor Parella, Karinne Miqueu, Abderrahmane Amgoune, Xavi Ribas, Didier Bourissou
Gold(iii) complexes are garnering increasing interest for opto-electronic, therapeutic and catalytic applications. But so far, very little is known about the factors controlling their reactivity and the very influence of the ancillary ligand. This article reports the first comprehensive study on this topic. The reactivity of a cationic (N,C) gold(iii) complex, namely 1A , towards ethylene has been thoroughly studied and compared with that of the related (P,C) complex 1C . A cationic gold(iii) complex 5A resulting from double insertion of ethylene was selectively obtained...
April 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29777271/characteristics-and-outcomes-of-obstetric-brachial-plexus-palsy-in-a-single-saudi-centre-king-faisal-specialists-hospital-and-research-centre-an-experience-of-ten-years
#4
Omar A Al-Mohrej, Nehal A Mahabbat, Asad F Khesheaim, Nezar B Hamdi
BACKGROUND: Obstetric brachial plexus palsy (OBPP) is considered a rare, unpredictable, and unavoidable injury of the upper limb. In this study, we presented a retrospective cohort study over a period of ten years in King Faisal Specialists Hospital and Research Centre (KFSH&RC), Riyadh, Saudi Arabia, to assess the characteristics and functional outcomes of OBPP. METHODS: Between January 2005 and December 2015, we carried out 125 repairs of OBPP in KFSH&RC...
May 18, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29776724/outcomes-of-splinting-in-pediatric-mallet-finger
#5
James S Lin, Julie Balch Samora
PURPOSE: Excessive flexion at the distal interphalangeal (DIP) joint disrupts the extensor mechanism, leading to mallet finger injuries. The goal of management is to restore active DIP joint extension. We sought to learn which variables (treatment technique, injury type, time to presentation, adherence to treatment) affect clinical outcomes of pediatric mallet finger injuries. METHODS: A retrospective review was performed of patients who presented with mallet finger injuries during 2013 to 2017 at a large pediatric hospital...
May 15, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29773462/derotation-of-the-mallet-piece-a-crucial-point-in-mallet-fracture-surgery
#6
B Karslıoğlu, M Uzun, C Tetik, E Tasatan, A C Tekin, C D Buyukkurt
Mallet fracture is an avulsion of the extensor tendon and fracture of the dorsal rim of the articular surface of distal phalanx at the same time. If a part of the mallet fracture is angled or rotated to such a degree that prevents full anatomic reduction, malunion and deformities may occur as a result. The objective of this study was to describe a new surgical technique to provide derotation of the mallet fracture. A 22G or 21G needle is used like a joystick to reduce the mallet fracture with small, gentle movements...
May 14, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29771177/a-lateral-band-flap-for-a-open-mallet-finger-with-skin-and-tendon-loss-a-case-report
#7
Chul-Hyung Lee, Cheol-U Kim
No abstract text is available yet for this article.
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29763385/pyruvate-enriched-resuscitation-for-shock
#8
Robert T Mallet, Albert H Olivencia-Yurvati, Rolf Bünger
This commentary addresses the recent retraction of an article which reported favorable outcomes in septic patients treated with intravenous pyruvate. The retracted report was cited in the authors' recent minireview on the cellular mechanisms and clinical application of pyruvate to improve cardiac performance. Because the retracted article reports pyruvate-enhanced resuscitation of critically ill patients, the authors wish to inform the readership, especially critical care providers, that this particular clinical application of pyruvate is not now supported by robust evidence...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29757361/effects-of-rhinoplasty-on-labyrinthine-function
#9
Ahmet Mahmut Tekin, Erkan Soylu, Handan Turan Dizdar, Fahrettin Yilmaz, Yildirim Ahmet Bayazit
Background: Rhinoplasty is a common surgical procedure that is requested and accepted by patients for cosmetic and functional reasons. Osteotomies are performed on nasal bone, maxillary crest, or vomer to fix the deviations of the nasal dorsum or septum. During the percussion of the osteotomes with the surgical mallet, the vibration energy diffuses to the cranium. Auditory and vestibular systems may be affected by these vibrations. Objectives: To assess the effects of rhinoplasty, in which osteotomies were performed using a hammer, on the audiovestibular system...
May 11, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29755840/treatment-of-mallet-finger-deformity-with-a-modified-palmaris-longus-tendon-graft-through-a-bone-tunnel
#10
Zengbing Liu, Kai Ma, Dong Huang
OBJECTIVE: To investigate the clinical effect of treating mallet finger deformity using a modified palmaris longus tendon graft through a bone tunnel. METHODS: Altogether, 21 patients with mallet finger deformity (16 men, 5 women; average age 31 years, range 19-47 years) were treated with a modified palmaris longus tendon graft through a bone tunnel during 18 months (2014-2016). Four index fingers, seven middle fingers, eight ring fingers, and two little fingers were treated for four cutting injuries, eleven finger sprains, four crush injuries, and two twist injuries (7 open and 14 closed injuries)...
2018: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29736841/evaluation-of-the-interaction-of-amino-acid-infusion-on-177-lu-dotatate-pharmacokinetics-in-patients-with-gastroenteropancreatic-neuroendocrine-tumors
#11
Alicja Puszkiel, Mathilde Bauriaud-Mallet, Roxane Bourgeois, Lawrence Dierickx, Frédéric Courbon, Etienne Chatelut
BACKGROUND AND OBJECTIVE: 177 Lu-Dotatate is a radio-labeled analog of somatostatin used in the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors. In order to prevent nephrotoxic effects of 177 Lu-Dotatate a co-infusion of amino acids (AA) is administered, resulting in a decrease in tubular renal reabsorption of 177 Lu-Dotatate. This study aimed to quantify the impact of AA co-infusion on the pharmacokinetics of 177 Lu-Dotatate in cancer patients and to evaluate its relationship with toxicity during the first treatment cycle (C1)...
May 8, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29734644/wildfire-smoke-plumes-transport-under-a-subsidence-inversion-climate-and-health-implications-in-a-distant-urban-area
#12
Elisabeth Alonso-Blanco, Amaya Castro, Ana I Calvo, Veronique Pont, Marc Mallet, Roberto Fraile
No abstract text is available yet for this article.
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29726315/the-risk-of-skin-tear-in-dupuytren-s-disease-when-treated-with-collagenase
#13
Christian Fagernæs, Susanne Mallet
INTRODUCTION: The purpose of this study was to explore if there was a correlation between joint level and degree of contracture on the one hand and the risk of skin tear in Dupuytren's disease (DD) on the other, when treated with collagenase from Clostridium histolyticum. No trial or study has explored the risk of skin tear as primary outcome in a population that has not been treated for DD before. METHODS: A retrospective study of prospectively collected data was performed on patients with DD treated with collagenase from 1 August 2012 to 1 April 2014...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29721272/contrasting-patterns-of-andean-diversification-among-three-diverse-clades-of-neotropical-clearwing-butterflies
#14
Nicolas Chazot, Donna Lisa De-Silva, Keith R Willmott, André V L Freitas, Gerardo Lamas, James Mallet, Carlos E Giraldo, Sandra Uribe, Marianne Elias
The Neotropical region is the most biodiverse on Earth, in a large part due to the highly diverse tropical Andean biota. The Andes are a potentially important driver of diversification within the mountains and for neighboring regions. We compared the role of the Andes in diversification among three subtribes of Ithomiini butterflies endemic to the Neotropics, Dircennina, Oleriina, and Godyridina. The diversification patterns of Godyridina have been studied previously. Here, we generate the first time-calibrated phylogeny for the largest ithomiine subtribe, Dircennina, and we reanalyze a published phylogeny of Oleriina to test different biogeographic scenarios involving the Andes within an identical framework...
April 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29705242/epithelial-barrier-dysfunction-in-desmoglein-1-deficiency
#15
Laura Polivka, Smail Hadj-Rabia, Elodie Bal, Stéphanie Leclerc-Mercier, Marine Madrange, Yamina Hamel, Damien Bonnet, Stéphanie Mallet, Hubert Lepidi, Caroline Ovaert, Patrick Barbet, Christophe Dupont, Bénédicte Neven, Arnold Munnich, Lisa M Godsel, Florence Campeotto, Robert Weil, Emmanuel Laplantine, Sylvie Marchetto, Jean-Paul Borg, William I Weis, Jean-Laurent Casanova, Anne Puel, Kathleen J Green, Christine Bodemer, Asma Smahi
Desmoglein-1 deficiency is a missing link between impaired epithelial barrier function and immunological dysregulation. Our characterization of SAMEC syndrome highlighted the pivotal role of the desmoglein-1/ERBIN interaction as an inhibitor of skin inflammation via the NF-κB signaling pathway.
April 26, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29703684/surgical-treatment-for-chronic-tendon-mallet-injury
#16
REVIEW
Taku Suzuki, Takuji Iwamoto, Kazuki Sato
A variety of surgical options for chronic tendon mallet fingers have been reported. There are advantages and disadvantages to current surgical approaches. We introduce a surgical treatment for chronic tendon mallet injury that involves anatomical reconstruction of the terminal tendon and lateral band with palmaris longus (PL) tendon grafting. Harvested PL tendon is folded in 2 or divided into 2 slips. The graft is attached to a remnant of the original terminal tendon at the distal interphalangeal joint. Both half-slip tendons are passed under the transverse retinacular ligament and sutured side to side to the lateral band at the level of the proximal phalanx...
April 24, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29701937/mediation-analyses-of-insight-quality-of-life-depression-and-suicidality-results-from-the-face-sz-cohort
#17
Paul Roux, David Misdrahi, Delphine Capdevielle, Bruno Aouizerate, Fabrice Berna, Lore Brunel, Isabelle Chereau, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Catherine Faget-Agius, Sandrine Fonteneau, Franck Gabayet, Pierre Michel Llorca, Jasmina Mallet, Romain Rey, Raphaëlle Richieri, Aurélie Schandrin, Franck Schürhoff, Arnaud Tessier, Pierre Vidailhet, Christine Passerieux, Mathieu Urbach
OBJECTIVE: The relationship between greater insight and increased risk of suicide in patients with schizophrenia is debated. The purpose of this study was to assess whether quality of life (QoL) and depression mediated the association between insight and suicidality. METHODS: Between March 2010 and December 2015, 527 community-dwelling adults with stable schizophrenia according to DSM-IV criteria were included in a multicenter cross-sectional study, the FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Study...
April 17, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29691323/invasive-insect-hybridizes-with-local-pests
#18
James Mallet
No abstract text is available yet for this article.
April 24, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29678770/self-reported-pain-in-patients-with-schizophrenia-results-from-the-national-first-step-face-sz-cohort
#19
Guillaume Fond, Laurent Boyer, Meja Andrianarisoa, Ophelia Godin, Ewa Bulzacka, Fabrice Berna, Lore Brunel, Nathalie Coulon, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Thierry D'amato, Hélène Denizot, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Sylvain Leignier, Jasmina Mallet, David Misdrahi, Romain Rey, Christophe Lancon, Christine Passerieux, Aurélie Schandrin, Mathieu Urbach, Pierre Vidailhet, Marion Leboyer, Franck Schurhoff, Pierre-Michel Llorca, M Andrianarisoa, B Aouizerate, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, Danion Jm, T D'Amato, A Deloge, C Delorme, H Denizot, J M Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, R M Honciuc, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, R Rey, C Roman, M Sebilleau, A Schandrin, F Schurhoff, A Tessier, Tronche Am, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek, A Zinetti-Bertschy
INTRODUCTION: Little is known about perception of physical pain in schizophrenia (SZ). Some studies have suggested that patients with SZ may have an increased pain threshold, while others have suggested that patients with SZ may suffer from undetected and untreated high physical pain levels. The objectives of this study were (i) to investigate the prevalence of self-reported physical pain in stabilized SZ subjects, and (ii) to determine whether physical pain was associated with psychiatric characteristics and somatic comorbidities (iii) to determine whether antidepressants and benzodiazepine administration were associated with lower self-reported pain...
April 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29661472/news-about-the-genetics-of-congenital-primary-adrenal-insufficiency
#20
Florence Roucher-Boulez, Delphine Mallet-Motak, Véronique Tardy-Guidollet, Rita Menassa, Claire Goursaud, Ingrid Plotton, Yves Morel
Primary adrenal insufficiency (PAI) is characterized by impaired production of steroid hormones due to an adrenal cortex defect. This condition incurs a risk of acute insufficiency which may be life-threatening. Today, 80% of pediatric forms of PAI have a genetic origin but 5% have no clear genetic support. Recently discovered mutations in genes relating to oxidative stress have opened the way to research on genes unrelated to the adrenal gland. Identification of causal mutations in a gene responsible for PAI allows genetic counseling, guidance of follow-up and prevention of complications...
April 13, 2018: Annales D'endocrinologie
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