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Renoprotection

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https://www.readbyqxmd.com/read/29042548/human-mesenchymal-stromal-cells-transplanted-into-mice-stimulate-renal-tubular-cells-and-enhance-mitochondrial-function
#1
Luca Perico, Marina Morigi, Cinzia Rota, Matteo Breno, Caterina Mele, Marina Noris, Martino Introna, Chiara Capelli, Lorena Longaretti, Daniela Rottoli, Sara Conti, Daniela Corna, Giuseppe Remuzzi, Ariela Benigni
Mesenchymal stromal cells (MSCs) are renoprotective and drive regeneration following injury, although cellular targets of such an effect are still ill-defined. Here, we show that human umbilical cord (UC)-MSCs transplanted into mice stimulate tubular cells to regain mitochondrial mass and function, associated with enhanced microtubule-rich projections that appear to mediate mitochondrial trafficking to create a reparative dialogue among adjacent tubular cells. Treatment with UC-MSCs in mice with cisplatin-induced acute kidney injury (AKI) regulates mitochondrial biogenesis in proximal tubuli by enhancing PGC1α expression, NAD(+) biosynthesis and Sirtuin 3 (SIRT3) activity, thus fostering antioxidant defenses and ATP production...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29022917/trehalose-protects-against-cadmium-induced-cytotoxicity-in-primary-rat-proximal-tubular-cells-via-inhibiting-apoptosis-and-restoring-autophagic-flux
#2
Xin-Yu Wang, Heng Yang, Min-Ge Wang, Du-Bao Yang, Zhen-Yong Wang, Lin Wang
Autophagy has an important renoprotective function and we recently found that autophagy inhibition is involved in cadmium (Cd)-induced nephrotoxicity. Here, we aimed to investigate the protective effect of trehalose (Tre), a novel autophagy activator, against Cd-induced cytotoxicity in primary rat proximal tubular (rPT) cells. First, data showed that Tre treatment significantly decreased Cd-induced apoptotic cell death of rPT cells via inhibiting caspase-dependent apoptotic pathway, evidenced by morphological analysis, flow cytometric and immunoblot assays...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020797/extracellular-superoxide-dismutase-attenuates-renal-oxidative-stress-through-the-activation-of-ampk-in-diabetic-nephropathy
#3
Yu Ah Hong, Ji Hee Lim, Min Young Kim, Yaeni Kim, Hoon Suk Park, Hyung Wook Kim, Bum Soon Choi, Yoon Sik Chang, Hye Won Kim, Tae-Yoon Kim, Cheol Whee Park
AIMS: Oxidative stress plays a crucial role in the pathogenesis of diabetic nephropathy. We evaluated whether extracellular superoxide dismutase (EC-SOD) has a renoprotective effect through activation of AMPK in diabetic kidneys. RESULTS: Human recombinant EC-SOD (hEC-SOD) was administered to 8-week-old male C57BLKS/J db/db mice via subcutaneous injection once a week for 8 weeks. Renal SOD3 expression was suppressed in db/db mice, which was significantly enhanced by hEC-SOD treatment...
October 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28994737/anti-inflammatory-pyranochalcone-derivative-attenuates-lps-induced-acute-kidney-injury-via-inhibiting-tlr4-nf-%C3%AE%C2%BAb-pathway
#4
Min Shi, Xiaoxi Zeng, Fan Guo, Rongshuang Huang, Yanhuan Feng, Liang Ma, Li Zhou, Ping Fu
Treatment of septic acute kidney injury (AKI) has still been beyond satisfaction, although anti-inflammatory therapy is beneficial for sepsis-induced AKI. Compound 5b was derived from natural pyranochalcones and exhibited potent anti-inflammatory activity in adjuvant-induced arthritis. In this study, we aimed to investigate the renoprotective effects and potential mechanism of 5b against lipopolysaccharide (LPS)-induced AKI. C57BL/6 mice and human renal proximal tubule cell line (HK-2 cell) were treated with LPS, respectively...
October 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28994675/comparison-of-the-renoprotective-effect-of-dexmedetomidine-and-dopamine-in-high-risk-renal-patients-undergoing-cardiac-surgery-a-double-blind-randomized-study
#5
Rabie Soliman, Mohamed Hussien
OBJECTIVE: The purpose of the current study was to compare the renoprotective effects of continuous infusion of dexmedetomidine and dopamine in high-risk renal patients undergoing cardiac surgery. DESIGN: A double-blind randomized study. SETTING: Cardiac Centers. PATIENTS: One hundred and fifty patients with baseline serum creatinine level ≥1.4 mg/dl were scheduled for cardiac surgery with cardiopulmonary bypass. INTERVENTION: The patients were classified into two groups (each = 75): Group Dex - the patients received a continuous infusion of dexmedetomidine 0...
October 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28992288/erlotinib-attenuates-the-progression-of-chronic-kidney-disease-in-rats-with-remnant-kidney
#6
Yasutaka Yamamoto, Masayuki Iyoda, Shohei Tachibana, Kei Matsumoto, Yukihiro Wada, Taihei Suzuki, Ken Iseri, Tomohiro Saito, Kei Fukuda-Hihara, Takanori Shibata
Background: Increasing evidence indicates that epidermal growth factor receptor (EGFR) has a pathogenic role in renal fibrosis. Currently no effective treatment can completely halt the progression of chronic kidney disease (CKD). This study was undertaken to investigate the renoprotective effects of erlotinib, a tyrosine kinase inhibitor that can block EGFR activity in the progression of CKD and the mechanisms involved. Methods: Sprague Dawley rats with 5/6 nephrectomy were administered either erlotinib or vehicle from 2 weeks after surgery and for a period of 8 weeks...
September 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28992263/desphospho-uncarboxylated-matrix-gla-protein-is-a-novel-circulating-biomarker-predicting-deterioration-of-renal-function-in-the-general-population
#7
Fang-Fei Wei, Sander Trenson, Lutgarde Thijs, Qi-Fang Huang, Zhen-Yu Zhang, Wen-Yi Yang, Paula Moliterno, Karel Allegaert, José Boggia, Stefan Janssens, Peter Verhamme, Cees Vermeer, Jan A Staessen
Background: Recent studies showing an inverse association between estimated glomerular filtration rate (eGFR), a microvascular trait, and inactive desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) support the hypothesis that after vitamin K-dependent activation, matrix Gla protein (MGP) is renoprotective, but these were limited by their cross-sectional design. Methods: In 1009 randomly recruited Flemish (50.6% women), we assessed the association between eGFR and plasma dp-ucMGP, using multivariable-adjusted analyses...
August 25, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28992060/heterozygosity-of-mitogen-activated-protein-kinase-organizer-1-ameliorates-diabetic-nephropathy-and-suppresses-epithelial-to-mesenchymal-transition-like-changes-in-db-db-mice
#8
Ivonne Loeffler, Marita Liebisch, Christoph Daniel, Kerstin Amann, Gunter Wolf
Background: Progressive diabetic nephropathy (DN) is characterized by tubulointerstitial fibrosis that is caused by accumulation of extracellular matrix. Induced by several factors, matrix-producing myofibroblasts may to some extent originate from tubular cells by epithelial-to-mesenchymal transition (EMT). Although previous data document that activation of hypoxia-inducible factor (HIF) signalling can be renoprotective in acute kidney disease, this issue remains controversial in chronic kidney injury...
July 12, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28990729/renoprotective-effects-of-topiroxostat-for-hyperuremic-patients-with-overt-diabetic-nephropathy-study-etude-study-a-prospective-randomized-multicenter-clinical-trial
#9
Toshihiro Mizukoshi, Sawako Kato, Masahiko Ando, Hiroshi Sobajima, Norimi Ohashi, Tomohiko Naruse, Yosuke Saka, Hideaki Shimizu, Takanobu Nagata, Shoichi Maruyama
AIM: We aimed to evaluate the anti-albuminuric effects of topiroxostat in Japanese hyperuricemic patients with diabetic nephropathy. METHODS: In this 24-week, multicenter, open-label, randomized (1:1) trial, we assigned hyperuricemic patients with diabetic nephropathy (estimated glomerular filtration rate ≥ 20 mL/min/1.73m(2) ) and overt proteinuria (0.3 ≤ urine protein to creatinine ratio (UPCR) <3.5 g/g Cr) to either high dose (160 mg daily) or low dose (40 mg daily) topiroxostat...
October 9, 2017: Nephrology
https://www.readbyqxmd.com/read/28989173/diabetic-nephropathy-renoprotective-effects-of-glp1r-agonists-and-sglt2-inhibitors
#10
Berthold Hocher, Oleg Tsuprykov
No abstract text is available yet for this article.
October 9, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28986066/the-crosstalk-between-sirt1-and-keap1-nrf2-are-anti-oxidative-pathway-forms-a-positive-feedback-loop-to-inhibit-fn-and-tgf-%C3%AE-1-expressions-in-rat-glomerular-mesangial-cells
#11
Kaipeng Huang, Xiang Gao, Wentao Wei
Oxidative stress aroused by advanced glycation-end products (AGEs) is a culprit in the pathological progression of diabetic nephropathy. Both Sirt1 and the Keap1/Nrf2/ARE anti-oxidative pathway exert crucial inhibitory effects on the development of diabetic nephropathy. Our previous study has confirmed that Sirt1 activation can inhibit the upregulation of fibronectin (FN) and transforming growth factor-β1 (TGF-β1) by promoting Keap1/Nrf2/ARE pathway in glomerular mesangial cells (GMCs) challenged with AGEs...
October 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28978980/role-of-bardoxolone-methyl-a-nuclear-factor-erythroid-2-related-factor-2-activator-in-aldosterone-and-salt-induced-renal-injury
#12
Mikako Hisamichi, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki
The aim of this study was to investigate the renoprotective effect of bardoxolone methyl (BM), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator with an antioxidant effect, in a salt-sensitive hypertension model induced by aldosterone (Ald) and salt. Tubulointerstitial damage with urinary liver-type fatty acid-binding protein (L-FABP) was evaluated using human L-FABP chromosomal transgenic (L-FABP(+/-)) male mice. The mice in the Ald group (n=7) received systemic Ald infusions via an osmotic minipump and were given 1% NaCl water for 35 days...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28974016/high-endogenous-accumulation-of-%C3%AF-3-polyunsaturated-fatty-acids-protect-against-ischemia-reperfusion-renal-injury-through-ampk-mediated-autophagy-in-fat-1-mice
#13
Do Hyeong Gwon, Tae Woong Hwang, Ju-Ye Ro, Yoon-Joong Kang, Jin Young Jeong, Do-Kyung Kim, Kyu Lim, Dong Woon Kim, Dae Eun Choi, Jwa-Jin Kim
Regulated autophagy is involved in the repair of renal ischemia-reperfusion injury (IRI). Fat-1 transgenic mice produce ω3-Polyunsaturated fatty acids (ω3-PUFAs) from ω6-Polyunsaturated fatty acids (ω6-PUFAs) without a dietary ω3-PUFAs supplement, leading to a high accumulation of omega-3 in various tissues. ω3-PUFAs show protective effects against various renal injuries and it has recently been reported that ω3-PUFAs regulate autophagy. We assessed whether ω3-PUFAs attenuated IR-induced acute kidney injury (AKI) and evaluated its associated mechanisms...
September 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28970255/dietary-methionine-restriction-modulates-renal-response-and-attenuates-kidney-injury-in-mice
#14
Diana Cooke, Amadou Ouattara, Gene P Ables
Methionine restriction (MR) extends the lifespan across several species, such as rodents, fruit flies, roundworms, and yeast. MR studies have been conducted on various rodent organs, such as liver, adipose tissue, heart, bones, and skeletal muscle, to elucidate its benefits to the healthspan; however, studies of the direct effect of MR on kidneys are lacking. To investigate the renal effects of MR, we used young and aged unilateral nephrectomized and 5/6 nephrectomized (5/6Nx) mice. Our studies indicated that MR mice experienced polydipsia and polyuria compared with control-fed counterparts...
September 28, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28970015/scoparone-attenuates-high-glucose-induced-extracellular-matrix-accumulation-in-rat-mesangial-cells
#15
Yunqian Wang, Min Wang, Baoping Chen, Jun Shi
Scoparone, a major constituent of Artemisia capillaries, has a variety of biological properties including anticoagulant, hepatoprotective, anti-tumor, anti-fibrosis, anti-inflammatory, antioxidant, and antidiabetic activities. However, the renoprotective effect of scoparone under diabetic conditions remains elusive. Thus, the present study was undertaken to examine the role of scoparone in high glucose-induced mesangial cell proliferation and extracellular matrix (ECM) accumulation and elucidate the possible mechanism of action of scoparone...
September 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28962085/effects-of-apigenin-pretreatment-against-renal-ischemia-reperfusion-injury-via-activation-of-the-jak2-stat3-pathway
#16
Yang Liu, Lei Wang, Yang Du, Zhiyuan Chen, Jia Guo, Xiaodong Weng, Xiao Wang, Min Wang, Danyang Chen, Xiuheng Liu
The aim of our study is to investigate the protective effect of apigenin and the role of the JAK2/STAT3 signaling pathway in renal ischemia/reperfusion injury (IRI) in rats. For in vivo experiments, rat kidneys were subjected to 45min of ischemia, followed by 24h of reperfusion. The kidneys were pretreated for 24h with apigenin (4mg/kg) intraperitoneally in the absence or presence of the JAK2 kinase-specific inhibitor AZD1480 (30mg/kg). The serum creatinine and urea nitrogen levels were analyzed. Histologic examinations were evaluated...
September 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28952702/-reflux-nephropathy-in-children-early-diagnosis-and-monitoring
#17
O L Morozova, D A Morozov, D Y Lakomova, V V Iakovlev, V V Rostovskaya, I A Budnik, L D Maltseva
Vesicoureteral reflux (VUR) is the most common type of obstructive uropathy in children. Reflux nephropathy (RN) is one of the most common complications of VUR that inevitably leads to chronic kidney disease. Patients with end-stage kidney disease require costly treatment, and the only way to cure them is kidney transplantation. A timely institution of renoprotective therapy is a key factor helping to preserve the function of the native kidneys. Hence, it is necessary to devise new highly sensitive and minimally invasive methods for early diagnosis of RN...
September 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28947737/gender-differences-in-the-acute-kidney-injury-to-chronic-kidney-disease-transition
#18
Ixchel Lima-Posada, Cinthya Portas-Cortés, Rosalba Pérez-Villalva, Francesco Fontana, Roxana Rodríguez-Romo, Rodrigo Prieto, Andrea Sánchez-Navarro, Guadalupe L Rodríguez-González, Gerardo Gamba, Elena Zambrano, Norma A Bobadilla
This study evaluated if there is a sexual dimorphism in the acute kidney injury (AKI) to chronic kidney disease (CKD) transition and the time-course of the potential mechanisms involved in the dimorphic response. Female and male rats were divided into sham-operated or underwent 45-min renal ischemia (F + IR, and M + IR). All groups were studied at 24-h and 1, 2, 3, or 4-months post-ischemia. Additionally, oophorectomized rats were divided into sham or IR groups. After 24-h, AKI extent was simllar in females and males, but female rats exhibited less oxidative stress and increased renal GSH content...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28946766/salvia-miltiorrhiza-lipophilic-fraction-attenuates-oxidative-stress-in-diabetic-nephropathy-through-activation-of-nuclear-factor-erythroid-2-related-factor-2
#19
Lin An, Mei Zhou, Faiz M M T Marikar, Xue-Wen Hu, Qiu-Yun Miao, Ping Li, Jun Chen
Diabetic nephropathy (DN) is a common cause of chronic kidney disease and end-stage renal disease, which can be triggered by oxidative stress. In this study, we investigated the renoprotective effect of the ethyl acetate extract of Salvia miltiorrhiza (EASM) on DN and examined the underlying molecular mechanism. We observed that EASM treatment attenuated metabolic abnormalities associated with hyperglycemic conditions in the experimental DN model. In streptozotocin (STZ)-induced mice, EASM treatment reduced albuminuria, improved renal function and alleviated the pathological alterations within the glomerulus...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28944925/autophagy-is-activated-to-protect-renal-tubular-epithelial-cells-against-iodinated-contrast-media%C3%A2-induced-cytotoxicity
#20
Na Liu, Rong Lei, Mi-Mi Tang, Wei Cheng, Min Luo, Qian Xu, Shao-Bin Duan
With the steady increase in the use of various contrast‑related technologies in recent years, contrast‑induced nephropathy has received significant attention from clinicians and researchers. The present study aimed to determine the potential role of autophagy in iodinated contrast media (CM)‑induced cell injury and apoptosis in human proximal renal tubular epithelial HK‑2 cells. The present study used the iodinated CM iohexol (200 mg iodine/ml) to treat HK‑2 cells for 6 h, in order to establish a damaged cell model...
September 25, 2017: Molecular Medicine Reports
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