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Type 2 diabetes mellitus

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https://www.readbyqxmd.com/read/29793084/subthreshold-depression-among-diabetes-patients-in-beijing-cross-sectional-associations-among-sociodemographic-clinical-and-behavior-factors
#1
Dandan Wang, Lintao Shi, Leling Li, Xiaohui Guo, Yufeng Li, Yuan Xu, Shinan Yin, Qiaozhen Wu, Yu Yang, Xiaoming Zhuang, Yingli Gai, Quanmin Li, Yanjun Liu
BACKGROUND: This study explores the prevalence of subthreshold depression (SubD) and its association with factors in type 2 diabetes mellitus (T2DM) patients. METHODS: This cross-sectional study involved 808 outpatients with T2DM from ten hospitals in Beijing between September 2015 and January 2016. All participants completed the Patient Health Questionnaire 9-item (PHQ-9) to evaluate depressive status, with scores between 5 and 14 considered SubD. Conditional logistic regression was conducted to investigate the variables associated with SubD in T2DM patients...
May 18, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29792143/recent-updates-on-novel-approaches-in-insulin-drug-delivery-a-review-of-challenges-and-pharmaceutical-implications
#2
Manisha Pandey, Hira Choudhury, Cheah Xiao Yi, Chen Wei Mun, Goh Khang Ping, Guee Xin Rou, Bhalqish Jeet Kaur A/P Ambar Jeet Singh, Angel Ng Ann Jhee, Lee Kai Chin, Prashant Kesharwani, Bapi Gorain, Zahid Hussain
Diabetes mellitus, a metabolic disorder of glucose metabolism, is mainly associated with insulin resistance to the body cells, or impaired production of insulin by the pancreatic β-cells. Insulin is mainly required to regulate glucose metabolism in type 1 diabetes mellitus patients; however, many patients with type 2 diabetes mellitus also require insulin, especially when their condition cannot be controlled solely by oral hypoglycemic agents. Hence, major researches are ongoing attempting to improve the delivery of insulin in order to make it more convenient to patients who experience side effects from the conventional treatment procedure or non-adherence to insulin regimen due to multiple comorbid conditions...
May 22, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29791640/factors-associated-to-the-dependence-of-older-adults-with-diabetes-mellitus-type-2
#3
Adélia Dayane Guimarães Fonseca, Carla Silvana de Oliveira E Silva, Dulce Aparecida Barbosa, Elaine Cristina Santos Alves, Lucinéia de Pinho, Maria Fernanda Santos Figueiredo Brito, Mônica Antar Gamba
OBJECTIVE: to identify factors associated to the dependence of older adults with Diabetes Mellitus, Type 2 Method: analytical and epidemiological study with 99 older adults. The Brazilian Multidimensional Functional Assessment Questionnaire and a questionnaire composed by socio-demographic and clinical variables were used. The independent variables were described and compared to the level of dependence obtained by the chi-square test or the Fisher test, the strength of association was estimated by Odds Ratio and multiple regression...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791512/cpr-ir-is-an-insulin-resistance-index-that-is-minimally-affected-by-hepatic-insulin-clearance-a-preliminary-research
#4
Tsuyoshi Okura, Risa Nakamura, Yohei Fujioka, Sonoko Kawamoto-Kitao, Yuichi Ito, Kazuhisa Matsumoto, Kyoko Shoji, Keisuke Sumi, Kazuhiko Matsuzawa, Shoichiro Izawa, Etsuko Ueta, Masahiko Kato, Takeshi Imamura, Shin-Ichi Taniguchi, Kazuhiro Yamamoto
BACKGROUND: Increased hepatic insulin clearance (HIC) is important in the pathophysiology of type 2 diabetes mellitus (T2DM). The aim of this study is to analyze an effective insulin resistance (IR) index that is minimally affected by HIC. METHODS: Our study involved 20 participants with T2DM and 21 healthy participants without diabetes (Non-DM). Participants underwent a meal tolerance test from which plasma glucose, insulin and serum C-peptide immunoreactivity (CPR) were measured, and HOMA-IR and HIC were calculated...
2018: PloS One
https://www.readbyqxmd.com/read/29791176/-a-consensual-therapeutic-recommendation-for-type-2-diabetes-mellitus-by-the-slovak-diabetes-society-2018
#5
Emil Martinka, Vladimír Uličiansky, Marián Mokáň, Ivan Tkáč, Peter Galajda, Silvia Dókušová, Zbynek Schroner
Type 2 diabetes mellitus is a heterogeneous medical condition involving multiple pathophysiological mechanisms. Its successful treatment requires an individualized approach and frequently combined therapy with utilizing its effect on multiple levels. Current possibilities enable the employment of such procedures to an incomparably greater extent than before. The effects of different classes of oral antidiabetic drugs on the reduction of glycemia and HbA1c is mutually comparable. However differences are observed in the proportions of patients who met the required criteria, regarding the increase in weight, incidence of hypoglycemia as well as the effect on cardiovascular, renal or oncologic morbidity and mortality, and severity of specific adverse effects, potential risks and contraindications...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791171/-diagnosis-of-mody-brief-overview-for-clinical-practice
#6
Jana Urbanová, Ludmila Brunerová, Jan Brož
Maturity Onset Diabetes of the Young (MODY) comprises inherited forms of diabetes mellitus caused by the mutations in the genes involved in the development, differentiation and function of beta-cells. The majority of patients with MODY remains misdiagnosed and erroneously classified as type 1 or type 2 diabetic patients. Correct MODY diagnosis is, however, essential since it enables individualization of treatment, assessment of the prognosis and identification of diabetes among patient´s relatives. Clinical presentation of MODY is highly variable and it could resemble other types of diabetes, thus identification of MODY patients might be difficult...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791170/effectiveness-and-safety-of-lixisenatide-for-treatment-of-diabetes-in-the-real-world-data-from-the-monitoring-registry-in-a-real-life-cohort-in-the-czech-and-slovak-republic
#7
Martin Haluzík, Alena Adamíková, Milan Běhunčík, Marek Macko, Radka Štěpánová
INTRODUCTION: GLP1 receptor agonist lixisenatide has demonstrated its efficacy in numerous clinical trials, nevertheless its real-life effectiveness data is limited. AIM: To describe effectiveness and safety of lixisenatide in routine clinical practice in the Czech Republic and the Slovak Republic, as recorded by the Registry-Based Observational Study. METHODS: Multinational, multicenter, observational, non-interventional, 6-month prospective product registry of patients with type 2 diabetes mellitus aged > 18 years who were initiating therapy with lixisenatide...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791054/incidence-of-childhood-type-1-diabetes-mellitus-in-crete
#8
D Mamoulakis, F Vrouvaki, V Louvari, E Galanakis
AIM: To investigate the epidemiology of childhood Type 1 diabetes mellitus in Crete over the last 25 years and to evaluate incidence trends over time. METHODS: The study included all children aged 0-14 years who live in Crete and were diagnosed during the 25-year period from 1 January 1992 to 31 December 2016. RESULTS: A total of 271 children were diagnosed with Type 1 diabetes during the 25-year period: 148 boys and 123 girls (boy:girl ratio 1...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790775/dental-periodontal-and-salivary-conditions-in-diabetic-children-associated-with-metabolic-control-variables-and-nutritional-plan-adherence
#9
C Y Díaz Rosas, E Cárdenas Vargas, J E Castañeda-Delgado, L A Aguilera-Galaviz, M C Aceves Medina
AIM: Diabetes mellitus is a chronic disease that has manifestations other than alterations in endocrine regulation or in metabolic pathways. Several diseases of the oral cavity have been associated with diabetes mellitus type 1 and 2 in young people according to their evolution. Scarce information exists regarding the role of diabetes and its association with the oral health status in paediatric diabetic patients. The aims of the study were to assess the quality of saliva, saliva acidogenicity, dental caries experience, fluorosis and periodontal status in diabetic patients and to evaluate their relationship with metabolic control variables and nutritional plan adherence...
June 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29790137/-diabetic-foot-neuropathy-and-related-factors-in-patients-with-type-2-diabetes-mellitus
#10
Tzu-Yu Chen, Chia-Huei Lin, Yue-Cune Chang, Chih-Hsin Wang, Yi-Jen Hung, Wen-Chii Tzeng
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) face a higher risk of diabetic foot neuropathy, which increases the risk of death. The early detection of factors that influence diabetic neuropathy reduces the risk of foot lesions, including foot ulcerations, lower extremity amputation, and mortality. PURPOSE: To explore the demographic, disease-characteristic, health-literacy, and foot-self-care-behavior factors that affect diabetic foot neuropathy in patients with T2DM...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29790129/duodenum-exclusion-alone-is-sufficient-to-improve-glucose-metabolism-in-stz-induced-diabetes-rats
#11
Weihang Wu, Li Lin, Zhixiong Lin, Weijin Yang, Zhicong Cai, Jie Hong, Jiandong Qiu, Chen Lin, Nan Lin, Yu Wang
BACKGROUND: Several studies have found that metabolic surgery can significantly improve glucose homeostasis; however, the intrinsic mechanisms remain unclear. Accumulating evidence suggests that duodenal bypass plays a crucial role in the treatment of type 2 diabetes mellitus (T2DM). Here, we aimed to evaluate the effect of duodenal reflux on glucose metabolism in T2DM. METHODS: A high-fat diet and low-dose streptozotocin (STZ) administration were used to induce T2DM in male rats, which were assigned to three experimental groups: sham operation (SO; n = 10), new duodenal-jejunal bypass (NDJB; n = 10), and new duodenal-jejunal bypass with a tube (NDJBT; n = 10)...
May 22, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29789692/pulse-pressure-amplification-and-cardiac-autonomic-dysfunction-in-patients-with-type-2-diabetes-mellitus
#12
Ioanna Eleftheriadou, George C Drosos, Anastasios Tentolouris, Konstantonis George, Petros P Sfikakis, Athanasios D Protogerou, Nikolaos Tentolouris
The main aim of this cross-sectional study was to investigate the association between pulse pressure amplification (PPA) and cardiac autonomic activity (baroreflex sensitivity (BRS) and heart rate variability (HRV)) in patients with type 2 diabetes mellitus (T2DM). In addition, we examined the association between cardiac autonomic activity and central hemodynamic parameters that may affect PPA such as augmentation index (AIx), aortic stiffness (pulse wave velocity (PWV)), and common carotid artery stiffness distensibility coefficient (DC)...
May 23, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29789397/the-wnt-antagonist-and-secreted-frizzled-related-protein-5-implications-on-lipid-metabolism-inflammation-and-type-2-diabetes-mellitus
#13
Ling-Bin Liu, Xiao-Dong Chen, Xiang-Yu Zhou, Qing Zhu
Various reports have suggested that secreted frizzled-related protein 5 (SFRP5) plays a regulatory role in the processes of cellular proliferation and differentiation, by means of inactivating the Wnt/β-catenin signaling pathway. Recently, SFRP5 has been identified as an anti-inflammatory adipokine, which may be induced during preadipocyte proliferation, differentiation, and maturation. This review aims to identify the recent progress in the research and development of SFRP5 that can play a role in influencing lipid metabolism, inflammation and type 2 diabetes mellitus (T2DM)...
May 22, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29789365/structural-alteration-of-gut-microbiota-during-the-amelioration-of-human-type-2-diabetes-with-hyperlipidemia-by-metformin-and-a-traditional-chinese-herbal-formula-a-multicenter-randomized-open-label-clinical-trial
#14
Xiaolin Tong, Jia Xu, Fengmei Lian, Xiaotong Yu, Yufeng Zhao, Lipeng Xu, Menghui Zhang, Xiyan Zhao, Jian Shen, Shengping Wu, Xiaoyan Pang, Jiaxing Tian, Chenhong Zhang, Qiang Zhou, Linhua Wang, Bing Pang, Feng Chen, Zhiping Peng, Jing Wang, Zhong Zhen, Chao Fang, Min Li, Limei Chen, Liping Zhao
Accumulating evidence implicates gut microbiota as promising targets for the treatment of type 2 diabetes mellitus (T2DM). With a randomized clinical trial, we tested the hypothesis that alteration of gut microbiota may be involved in the alleviation of T2DM with hyperlipidemia by metformin and a specifically designed herbal formula (AMC). Four hundred fifty patients with T2DM and hyperlipidemia were randomly assigned to either the metformin- or AMC-treated group. After 12 weeks of treatment, 100 patients were randomly selected from each group and assessed for clinical improvement...
May 22, 2018: MBio
https://www.readbyqxmd.com/read/29789274/incidence-of-type-1-diabetes-in-children-aged-below-18-years-during-2013-2015-in-northwest-turkey
#15
Şükran Poyrazoğlu, Rüveyde Bundak, Zehra Yavaş Abalı, Hasan Önal, Sevil Sarıkaya, Abdurrahman Akgün, Serpil Baş, Saygın Abalı, Abdullah Bereket, Erdal Eren, Ömer Tarım, Ayla Güven, Metin Yıldız, Derya Karaman Aksakal, Ayşegül Yüksel, Gülcan Seymen Karabulut, Şükrü Hatun, Tolga Özgen, Yaşar Cesur, Mehmet Azizoğlu, Emine Dilek, Filiz Tütüncüler, Esra Papatya Çakır, Bahar Özcabı, Olcay Evliyaoğlu, Songül Karadeniz, Fatma Dursun, Semih Bolu, İlknur Arslanoğlu, Gül Yeşiltepe Mutlu, Heves Kırmızıbekmez, Pınar İşgüven, Ala Üstyol, Erdal Adal, Ahmet Uçar, Nurcan Cebeci, Didem Bezen, Çiğdem Binay, Serap Semiz, Hüseyin Anıl Korkmaz, Nihal Memioğlu, Elif Sagsak, Havva Nur Peltek, Melek Yıldız, Teoman Akçay, Serap Turan, Tülay Güran, Zeynep Atay, Neşe Akcan, Filiz Çizmecioğlu, Oya Ercan, Aydilek Dağdeviren, Firdevs Baş, Halim İşsever, Feyza Darendeliler
OBJECTIVE: To assess the incidence of type 1 diabetes mellitus (T1DM) in children under 18 years of age in the northwest region of Turkey during 2013-2015. METHODS: All newly diagnosed T1DM cases were recorded prospectively during 2013-2015. Total as well as gender and age group specific (0-4, 5-9, 10-14 and 15-17 age) mean incidences per 100.000 per year were calculated. RESULTS: There were 1773 patients diagnosed during 2013-2015 (588 cases in 2013, 592 cases in 2014, 593 cases in 2015)...
May 23, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29789237/predictors-of-biochemical-recurrence-after-radical-prostatectomy-in-an-afro-caribbean-population-in-guadeloupe-french-west-indies
#16
L Brureau, E Emeville, L Multigner, P Blanchet
PURPOSE: Few studies have investigated predictive risk factors of biochemical recurrence (BCR) after radical prostatectomy (RP) in other than Caucasian and Asian populations. We aimed to identify pre- and post-operative predictors of BCR after RP in an Afro-Caribbean population in Guadeloupe (French West Indies). PATIENTS AND METHODS: The study included 964 patients who underwent RP for clinically localized prostate cancer between April 1, 2000 and December 31, 2010 in the University Hospital of Guadeloupe...
May 20, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29789207/antidiabetic-potential-of-phytochemicals-isolated-from-the-stem-bark-of-myristica-fatua-houtt-var-magnifica-bedd-sinclair
#17
B Prabha, S Neethu, S Lekshmy Krishnan, D R Sherin, M Madhukrishnan, R Ananthakrishnan, K B Rameshkumar, T K Manojkumar, P Jayamurthy, K V Radhakrishnan
Phytochemical investigation of the stem bark of Myristica fatua Houtt. led to the isolation of a new compound 1 (3-tridecanoylbenzoic acid), along with six known acylphenols (2-7). All the compounds displayed moderate inhibitory activity on α-amylase and significant activity on α-glucosidase; however malabaricone B (6) and C (7) were identified as potent α-glucosidase inhibitors with IC50 values of 63.70 ± 0.546, and 43.61 ± 0.620 µM respectively. Acylphenols (compounds 3-7) also showed significant antiglycation property...
May 19, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29789130/the-effects-of-alcohol-on-plasma-lipid-mediators-of-inflammation-resolution-in-patients-with-type-2-diabetes-mellitus
#18
Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M Hodgson, Ian Puddey, Trevor A Mori
BACKGROUND: Type 2 diabetes mellitus is characterized by peripheral insulin resistance and low-grade systemic inflammation. Inflammation resolution is recognised as an important process driven by specialised pro-resolving mediators of inflammation (SPMs) and has the potential to moderate chronic inflammation. Alcohol has the potential to affect synthesis of SPMs by altering key enzymes involved in SPM synthesis and may influence ongoing inflammation associated with Type 2 diabetes mellitus...
June 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29788966/dyslipidemia-prevalence-awareness-treatment-control-and-risk-factors-in-chinese-rural-population-the-henan-rural-cohort-study
#19
Xiaotian Liu, Songcheng Yu, Zhenxing Mao, Yuqian Li, Haiqing Zhang, Kaili Yang, Honglei Zhang, Ruihua Liu, Xinling Qian, Linlin Li, Ronghai Bie, Chongjian Wang
BACKGROUND: The prevalence of dyslipidemia continue to increase in recent decades in China, however, little is known about the recent prevalence, awareness, treatment, control, and potential risk factors of dyslipidemia in the rural areas of China. METHODS: A total of 39,207 participants aged 18-79 years were recruited for the epidemiological research from the Henan Rural Cohort study. The age- and sex-adjusted means (95% confidence intervals, CI) of serum lipid levels or percentages of prevalence, awareness, treatment, and control overall and in various population subgroups were estimated and compared by multiple linear regression or logistic regression...
May 22, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29788955/effect-of-canagliflozin-on-left-ventricular-diastolic-function-in-patients-with-type-2-diabetes
#20
Daisuke Matsutani, Masaya Sakamoto, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi, Kazunori Utsunomiya
BACKGROUND: Type 2 diabetes mellitus (T2DM) greatly increases the risks of cardiovascular disease and heart failure. In particular, left ventricular diastolic dysfunction that develops from the early stages of T2DM is an important factor in the onset and exacerbation of heart failure. The effect of sodium-glucose cotransporter 2 inhibitors on left ventricular diastolic function has not been elucidated. We have performed the first prospective study on the effects of canagliflozin on left ventricular diastolic function in T2DM...
May 22, 2018: Cardiovascular Diabetology
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