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https://www.readbyqxmd.com/read/28109567/evaluation-of-residual-abdominal-tumour-motion-in-carbon-ion-gated-treatments-through-respiratory-motion-modelling
#1
Giorgia Meschini, Matteo Seregni, Andrea Pella, Mario Ciocca, Piero Fossati, Francesca Valvo, Marco Riboldi, Guido Baroni
At the Italian National Centre for Oncologic Hadrontherapy (CNAO) patients with upper-abdominal tumours are being treated with carbon ion therapy, adopting the respiratory gating technique in combination with layered rescanning and abdominal compression to mitigate organ motion. Since online imaging of the irradiated volume is not feasible, this study proposes a modelling approach for the estimation of residual motion of the target within the gating window. The model extracts a priori respiratory motion information from the planning 4DCT using deformable image registration (DIR), then combines such information with the external surrogate signal recorded during dose delivery...
January 18, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28106615/metal-artifact-reduction-in-x-ray-computed-tomography-using-computer-aided-design-data-of-implants-as-prior-information
#2
Veikko Ruth, Daniel Kolditz, Christian Steiding, Willi A Kalender
OBJECTIVES: The performance of metal artifact reduction (MAR) methods in x-ray computed tomography (CT) suffers from incorrect identification of metallic implants in the artifact-affected volumetric images. The aim of this study was to investigate potential improvements of state-of-the-art MAR methods by using prior information on geometry and material of the implant. MATERIALS AND METHODS: The influence of a novel prior knowledge-based segmentation (PS) compared with threshold-based segmentation (TS) on 2 MAR methods (linear interpolation [LI] and normalized-MAR [NORMAR]) was investigated...
January 18, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28105886/interobserver-delineation-uncertainty-in-involved-node-radiation-therapy-inrt-for-early-stage-hodgkin-lymphoma-on-behalf-of-the-radiotherapy-committee-of-the-eortc-lymphoma-group
#3
Marianne C Aznar, Theodore Girinsky, Anne Kiil Berthelsen, Berthe Aleman, Max Beijert, Martin Hutchings, Yolande Lievens, Paul Meijnders, Peter Meidahl Petersen, Deborah Schut, Maja V Maraldo, Richard van der Maazen, Lena Specht
BACKGROUND AND PURPOSE: In early-stage classical Hodgkin lymphoma (HL) the target volume nowadays consists of the volume of the originally involved nodes. Delineation of this volume on a post-chemotherapy CT-scan is challenging. We report on the interobserver variability in target volume definition and its impact on resulting treatment plans. MATERIALS AND METHODS: Two representative cases were selected (1: male, stage IB, localization: left axilla; 2: female, stage IIB, localizations: mediastinum and bilateral neck)...
January 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28105885/denosumab-in-patients-with-giant-cell-tumor-of-bone-in-norway-results-from-a-nationwide-cohort
#4
Kjetil Boye, Nina Louise Jebsen, Olga Zaikova, Heidi Knobel, Ayca M Løndalen, Clement S Trovik, Odd R Monge, Kirsten Sundby Hall
BACKGROUND: Denosumab is a relatively new treatment option for patients with giant-cell tumor of bone (GCTB). The purpose of this study was to report the results for patients treated in Norway. MATERIALS AND METHODS: Patients treated with denosumab for GCTB were identified from the clinical databases at the Norwegian sarcoma reference centers. Data were retrieved from the clinical databases and supplemented by retrospective review of patient records. Denosumab was given as a subcutaneous injection every 4 weeks with loading doses on day 8 and 15 in cycle 1...
January 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28105713/whole-remnant-and-maximum-voxel-spect-ct-dosimetry-in-131-i-nai-treatments-of-differentiated-thyroid-cancer
#5
Pablo Mínguez, Glenn Flux, José Genollá, Alejandro Delgado, Emilia Rodeño, Katarina Sjögreen Gleisner
PURPOSE: To investigate the possible differences between SPECT/CT based whole-remnant and maximum-voxel dosimetry in patients receiving radio-iodine ablation treatment of differentiated thyroid cancer (DTC). METHODS: Eighteen DTC patients were administered 1.11 GBq of (131) I-NaI after near-total thyroidectomy and rhTSH stimulation. Two patients had two remnants, so in total dosimetry was performed for 20 sites. Three SPECT/CT scans were performed for each patient at 1, 2, and 3-7 days after administration...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/28104741/recombinant-human-thyroid-stimulating-hormone-versus-thyroid-hormone-withdrawal-in-124i-pet-ct-based-dosimetry-for-131i-therapy-of-metastatic-differentiated-thyroid-cancer
#6
Donika Plyku, Robert F Hobbs, Kevin Huang, Frank Atkins, Carlos Garcia, George Sgouros, Douglas Van Nostrand
PURPOSE: Patients with metastatic differentiated thyroid cancer (DTC) may be prepared using either thyroid stimulating hormone withdrawal (THW) or recombinant human thyroid-stimulating hormone (rhTSH) injections prior to (131)I administration for treatment. The objective of this study was to compare the absorbed dose (D) to the critical organs and tumors determined by (124)I-Positron Emission Tomography/Computed Tomography (PET/CT) based dosimetry for (131)I therapy of metastatic DTC when the same patient was prepared with and imaged after both THW and rhTSH injections...
January 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28104641/measured-head-ct-cta-skin-dose-and-intensive-care-unit-patient-cumulative-exposure
#7
R D Nawfel, G S Young
BACKGROUND AND PURPOSE: Estimates of cumulative CT/CTA radiation dose based on volumetric CT dose index have raised concern that neurological intensive care unit patient exposures may reach thresholds for deterministic skin injury. Because the accuracy of volumetric CT dose index for this purpose in unknown, we set out to directly measure head CT and CTA peak skin dose, assess the relationship of volumetric CT dose index to measured peak skin dose, and determine whether multiple CT/CTA exposures in typical patients in the neurological intensive care unit produce cumulative doses approaching or exceeding single-dose deterministic thresholds for skin injury...
January 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28104300/challenges-and-opportunities-in-primary-cns-lymphoma-a-systematic-review
#8
REVIEW
Mariana N Kerbauy, Fabio Y Moraes, Benjamin H Lok, Jennifer Ma, Lucila N Kerbauy, Daniel E Spratt, Fabio P S Santos, Guilherme F Perini, Alejandro Berlin, Caroline Chung, Nelson Hamerschlak, Joachim Yahalom
BACKGROUND: Historically, high-dose methotrexate (HD-MTX) plus consolidation chemotherapy and/or whole brain radiotherapy (WBRT) has been the gold standard on Primary Central Nervous System Lymphoma (PCNSL) management. We sought to examine and summarize the data, on clinical trial (CT) setting, investigating multi-modality treatment to PCNSL. METHODS: We performed a systematic review of electronic databases (Medline, EMBASE, Cochrane Database and clinicaltrials...
January 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28103709/radiation-absorbed-dose-estimates-for-18f-bpa-pet
#9
Yuzuru Kono, Hiroaki Kurihara, Hiroshi Kawamoto, Naoko Yasui, Naoki Honda, Hiroshi Igaki, Jun Itami
Background Boron neutron capture therapy (BNCT) is a molecular radiation therapy approach based on the (10)B (n, α) (7)Li nuclear reaction in cancer cells. In BNCT, delivery of (10)B in the form of 4-borono-phenylalanine conjugated with fructose (BPA-fr) to the cancer cells is important. The PET tracer 4-borono-2-18F-fluoro-phenylalanine (FBPA) has been used to predict the accumulation of BPA-fr before BNCT. Purpose To determine the biodistribution and dosimetric parameters in 18F-BPA PET/CT studies. Material and Methods Human biokinetic data were obtained during clinical 18F-BPA PET studies between February and June 2015 at one institution...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28103708/intravoxel-incoherent-motion-ivim-analysis-of-vertebral-bone-marrow-changes-after-radiation-exposure-from-diagnostic-imaging-and-interventional-procedures
#10
Min A Yoon, Suk-Joo Hong, Chang Hee Lee, Chang Ho Kang, Kyung-Sik Ahn, Baek Hyun Kim
Background High cumulative radiation dose in cancer patients warrants systemic examination of possible changes in bone marrow. Purpose To assess retrospectively changes in vertebral bone marrow diffusion and perfusion using intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in hepatocellular carcinoma (HCC) patients after exposure to radiation from diagnostic imaging and interventional procedures. Material and Methods A total of 21 IVIM-DWI sets in 20 HCC patients, consisting of baseline and follow-up liver magnetic resonance imaging (MRI) with an interval less than 100 days, were reviewed after varying levels of radiation exposure from transarterial chemoembolization (TACE), multiphase liver CT, and abdominal radiography...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28102959/x-ray-scatter-correction-for-multi-source-interior-computed-tomography
#11
Hao Gong, Hao Yan, Xun Jia, Bin Li, Ge Wang, Guohua Cao
PURPOSE: The schemes of multi-source interior computed tomography (CT) have shown promise for ultra-fast, organ-oriented, and low-dose dynamic imaging. Besides forward scattering, x-ray cross scattering from multiple x-ray sources activated simultaneously can further degrade image quality. Here, we investigate the overall x-ray scattering artifact in a recently proposed multi-source interior CT architecture, and present two methods for scatter correction. METHODS: Compared to single-source global CT, scattering in multi-source interior CT architecture is affected by two new factors: cross scattering from simultaneously activated multiple x-ray sources and region-of-interest (ROI) oriented interior CT mode...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102946/a-portal-dosimetry-dose-prediction-method-based-on-collapsed-cone-algorithm-using-the-clinical-beam-model
#12
J Martínez Ortega, N Gómez González, P Castro Tejero, M Pinto Monedero, N B Tolani, L Núñez Martín, R Sánchez Montero
PURPOSE: Amorphous silicon electronical portal imaging devices (EPIDs) are widely used for dosimetric measurements in Radiation Therapy. The purpose of this work was to determine if a portal dose prediction method can be utilized for dose map calculations based on the linear accelerator model within a commercial treatment planning system (Pinnacle(3) v8.0 m). METHODS: The method was developed for a 6 MV photon beam on the Varian Clinac 21-EX, at a nominal dose rate of 400 MU/min...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102707/patient-dosimetry-audit-for-establishing-local-diagnostic-reference-levels-for-nuclear-medicine-ct
#13
Matthew Gardner, Ngonidzashe M Katsidzira, Erin Ross, Elizabeth A Larkin
OBJECTIVES: To establish a system for patient dosimetry audit and setting of Local Diagnostic Reference Levels (LDRLs) for Nuclear Medicine (NM) CT. METHODS: Computed Radiological Information System (CRIS) data were matched with NM paper records which provided the body region and dose mode for NMCT carried out at a large UK hospital. It was necessary to divide data in terms of the NM examination type, body region and dose mode. The mean and standard deviation Dose Length Products (DLPs) for common NMCT examinations were then calculated and compared to the proposed National DRLs (NDRLs)...
January 19, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28102510/influence-of-dose-reduction-and-iterative-reconstruction-on-ct-calcium-scores-a-multi-manufacturer-dynamic-phantom-study
#14
N R van der Werf, M J Willemink, T P Willems, M J W Greuter, T Leiner
To evaluate the influence of dose reduction in combination with iterative reconstruction (IR) on coronary calcium scores (CCS) in a dynamic phantom on state-of-the-art CT systems from different manufacturers. Calcified inserts in an anthropomorphic chest phantom were translated at 20 mm/s corresponding to heart rates between 60 and 75 bpm. The inserts were scanned five times with routinely used CCS protocols at reference dose and 40 and 80% dose reduction on four high-end CT systems. Filtered back projection (FBP) and increasing levels of IR were applied...
January 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28102349/development-of-patient-specific-phantoms-for-verification-of-stereotactic-body-radiation-therapy-planning-in-patients-with-metallic-screw-fixation
#15
Dongryul Oh, Chae-Seon Hong, Sang Gyu Ju, Minkyu Kim, Bum Yong Koo, SungBack Choi, Hee Chul Park, Doo Ho Choi, Hongryull Pyo
A new technique for manufacturing a patient-specific dosimetric phantom using three-dimensional printing (PSDP_3DP) was developed, and its geometrical and dosimetric accuracy was analyzed. External body contours and structures of the spine and metallic fixation screws (MFS) were delineated from CT images of a patient with MFS who underwent stereotactic body radiation therapy for spine metastasis. Contours were converted into a STereoLithography file format using in-house program. A hollow, four-section PSDP was designed and manufactured using three types of 3DP to allow filling with a muscle-equivalent liquid and insertion of dosimeters...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101733/3d-absorbed-dose-distribution-estimated-by-monte-carlo-simulation-in-radionuclide-therapy-with-a-monoclonal-antibody-targeting-synovial-sarcoma
#16
David Sarrut, Jean-Noël Badel, Adrien Halty, Gwenaelle Garin, David Perol, Philippe Cassier, Jean-Yves Blay, David Kryza, Anne-Laure Giraudet
BACKROUND: Radiolabeled OTSA101, a monoclonal antibody targeting synovial sarcoma (SS) developed by OncoTherapy Science, was used to treat relapsing SS metastases following a theranostic procedure: in case of significant (111)In-OTSA101 tumor uptake and favorable biodistribution, patient was randomly treated with 370/1110 MBq (90)Y-OTSA101. Monte Carlo-based 3D dosimetry integrating time-activity curves in VOI was performed on (111)In-OTSA101 repeated SPECT/CT. Estimated absorbed doses (AD) in normal tissues were compared to biological side effects and to the admitted maximal tolerated absorbed dose (MTD) in normal organs...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28101354/histological-complete-response-in-a-patient-with-advanced-biliary-tract-cancer-treated-by-gemcitabine-cisplatin-s-1-combination-chemotherapy-a-case-report
#17
Tokuhiro Matsubara, Tsutomu Nishida, Yoshito Tomimaru, Masashi Yamamoto, Shiro Hayashi, Sachiko Nakajima, Koji Fukui, Keizo Dono, Shiro Adachi, Tatsuya Ioka, Masashi Kanai, Masami Inada
A 68-year-old woman was referred to our hospital with increased levels of biliary enzymes. On imaging, the patient was diagnosed with unresectable intrahepatic biliary tract cancer (BTC) with invasion of the portal vein and para-aortic lymph node metastasis (cT3N1M1, cStage IVb) and underwent endoscopic biliary drainage for the biliary stricture prior to therapy. The patient was subsequently enrolled in a phase III randomized trial (UMIN000014371/NCT02182778) and randomly assigned to receive gemcitabine/cisplatin/S-1 (GCS) combination therapy intravenously at doses of 1,000 or 25 mg/m(2) on day 1 and orally twice daily at a dose of 80 mg/m(2) on days 1-7 every 2 weeks...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28101193/-18-f-flt-and-18-f-fdg-pet-ct-imaging-in-the-evaluation-of-early-therapeutic-effects-of-chemotherapy-on-walker-256-tumor-bearing-rats
#18
Weina Xu, Shupeng Yu, Jun Xin, Qiyong Guo
The present study aimed to evaluate the early therapeutic effects of chemotherapy on Walker 256 tumor-bearing Wistar rats via F-18-fluoro-3'-deoxy-3'-L-fluorothymidine ((18)F-FLT) and F-18-fluoro-deoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) imaging. Walker 256 tumor-bearing Wistar rats were subjected to (18)F-FLT and (18)F-FDG PET-CT imaging prior to and 24 and 48 h after epirubicin chemotherapy. (18)F-FLT and (18)F-FDG uptake [tumor/muscle (T/M)], the percentage of injected dose per gram (% ID/g), and the Ki-67 labeling index (LI-Ki-67) were quantitatively determined for each rat prior to and following epirubicin chemotherapy...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100416/a-retrospective-analysis-of-the-clinical-effects-of-neoadjuvant-combination-therapy-with-full-dose-gemcitabine-and-radiation-therapy-in-patients-with-biliary-tract-cancer
#19
S Kobayashi, A Tomokuni, K Gotoh, H Takahashi, H Akita, S Marubashi, T Yamada, T Teshima, K Fukui, Y Fujiwara, M Sakon
PURPOSE: This study aims to evaluate survival and the objective response to neoadjuvant combination therapy with gemcitabine and radiation therapy in patients with biliary tract cancer. METHODS: The chemoradiation therapy regimen consisted of 3 cycles of full-dose gemcitabine (1000 mg/m(2) at days 1, 8, and 15, every 4 weeks) with 50-60 Gy radiation. We compared 27 patients who received neoadjuvant chemoradiation therapy and 79 patients who were treated without neoadjuvant therapy...
January 11, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28099294/examination-of-pediatric-radiation-dose-delivered-after-cervical-spine-trauma
#20
Laura K Somppi, Kristin A Frenn, Anupam B Kharbanda
OBJECTIVES: Pediatric cervical spine injuries (CSIs) are rare but potentially fatal injuries. Plain radiographs (x-rays) and computed tomography (CT) are used to diagnose CSIs. Given concerns related to radiation exposure, the utility of x-rays in diagnosing CSIs compared with other forms of imaging must be examined. METHODS: Patients younger than 19 years presenting with possible CSI to an urban tertiary care hospital who received imaging for possible CSI between January 1, 2011, and December 31, 2013, were included...
January 17, 2017: Pediatric Emergency Care
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