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https://www.readbyqxmd.com/read/29765954/an-unusual-presentation-of-esthesioneuroblastoma-in-a-young-pregnant-female
#1
Meenakshi Wadhwani, Amar Ranjan, Kulbhushan Gangwani, Prasenjit Das
Background: Esthesioneuroblastoma is a rare neuroepithelial tumor arising from the olfactory epithelium in the cribriform plate or nasal cavity. It accounts for 1-5% of cases of malignant neoplasms of the nasal cavity. Methods: A 20-year-old pregnant female presented with painful loss of vision in both eyes, on imaging diagnosed as meningioma. There was a progressive increase in pain along with diminution of vision to the extent of complete loss of vision in the right eye...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29755780/appendiceal-diverticulosis-a-harbinger-of-underlying-primary-appendiceal-adenocarcinoma
#2
Jia Lin Ng, Shing Lih Wong, Ronnie Mathew
Diagnosis of primary appendiceal adenocarcinoma (PAA) is hindered by its rarity and largely asymptomatic nature. Appendiceal diverticulosis (AD) is equally rare. We report an unusual case of PAA presenting with perforated appendiceal diverticulitis, and discuss a review of the literature about its association, and its surgical and pathological implications. A middle-aged man was admitted with right iliac fossa (RIF) pain and a corresponding tender abdominal mass for 5 days. Computerised tomography (CT) scan demonstrated a thickened appendix with 3 cm abscess at its base...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755766/percutaneous-irreversible-electroporation-with-systemic-treatment-for-locally-advanced-pancreatic-adenocarcinoma
#3
Edward Leen, John Picard, Justin Stebbing, Mark Abel, Tony Dhillon, Harpreet Wasan
Background: The prognosis for unresectable locally advanced pancreatic adenocarcinoma (LAPC) remains poor. There is increasing interest in modern ablative techniques to improve outcomes. We report on the potential value of integrating percutaneous irreversible electroporation (IRE) in patients undergoing systemic chemotherapy. Methods: Seventy-five patients with unresectable pancreatic carcinoma underwent percutaneous IRE after chemotherapy using computerised tomography guidance under general anaesthesia...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29750997/the-role-of-spatial-variations-of-abiotic-factors-in-mediating-intratumour-phenotypic-heterogeneity
#4
Tommaso Lorenzi, Chandrasekhar Venkataraman, Alexander Lorz, Mark A J Chaplain
We present here a space- and phenotype-structured model of selection dynamics between cancer cells within a solid tumour. In the framework of this model, we combine formal analyses with numerical simulations to investigate in silico the role played by the spatial distribution of abiotic components of the tumour microenvironment in mediating phenotypic selection of cancer cells. Numerical simulations are performed both on the 3D geometry of an in silico multicellular tumour spheroid and on the 3D geometry of an in vivo human hepatic tumour, which was imaged using computerised tomography...
May 8, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29709055/interventions-for-investigating-and-identifying-the-causes-of-stillbirth
#5
REVIEW
Aleena M Wojcieszek, Emily Shepherd, Philippa Middleton, Glenn Gardener, David A Ellwood, Elizabeth M McClure, Katherine J Gold, Teck Yee Khong, Robert M Silver, Jan Jaap Hm Erwich, Vicki Flenady
BACKGROUND: Identification of the causes of stillbirth is critical to the primary prevention of stillbirth and to the provision of optimal care in subsequent pregnancies. A wide variety of investigations are available, but there is currently no consensus on the optimal approach. Given their cost and potential to add further emotional burden to parents, there is a need to systematically assess the effect of these interventions on outcomes for parents, including psychosocial outcomes, economic costs, and on rates of diagnosis of the causes of stillbirth...
April 30, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29689434/estimating-the-cost-effectiveness-of-lung-cancer-screening-with-low-dose-computed-tomography-for-high-risk-smokers-in-australia
#6
Stephen Wade, Marianne Weber, Michael Caruana, Yoon-Jung Kang, Henry Marshall, Renee Manser, Shalini Vinod, Nicole Rankin, Kwun Fong, Karen Canfell
BACKGROUND: Health economic evaluations of lung cancer screening with low dose computerised tomography (LDCT) that are underpinned by clinical outcomes are few. METHODS: We assessed the cost-effectiveness of LDCT lung screening in Australia by applying Australian cost and survival data to the outcomes observed in the U.S. National Lung Screening Trial (NLST), in which a 20% lung cancer mortality benefit was demonstrated for three rounds of annual screening among high-risk smokers aged 55-74 years...
April 21, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29688849/cryptococcoma-of-a-transplanted-kidney-in-a-patient-presenting-with-recurrent-urinary-tract-infection-a-case-report
#7
Albert Z Muranda, Ludolf Greeff, Mike M Sathekge, Thabo Lengano, Victor O L Karusseit
BACKGROUND: Cryptococcosis is an important opportunistic infection of organ transplant recipients. It is the third most common fungal infection of transplant patients and occurs especially in kidney recipients. Cryptococcus neoformans is a ubiquitous fungus which infects humans by inhalation of spores. C. gattii has more recently been recognised as a pathogen. Infection commonly is disseminated affecting mainly the central nervous system and the lungs. Cryptococcoma, a localised form of the disease, has been described in various organs...
April 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29670888/computational-fluid-dynamic-analysis-of-the-left-atrial-appendage-to-predict-thrombosis-risk
#8
Giorgia Maria Bosi, Andrew Cook, Rajan Rai, Leon J Menezes, Silvia Schievano, Ryo Torii, Gaetano Burriesci
During Atrial Fibrillation (AF) more than 90% of the left atrial thrombi responsible for thromboembolic events originate in the left atrial appendage (LAA), a complex small sac protruding from the left atrium (LA). Current available treatments to prevent thromboembolic events are oral anticoagulation, surgical LAA exclusion, or percutaneous LAA occlusion. However, the mechanism behind thrombus formation in the LAA is poorly understood. The aim of this work is to analyse the hemodynamic behaviour in four typical LAA morphologies - "Chicken wing", "Cactus", "Windsock" and "Cauliflower" - to identify potential relationships between the different shapes and the risk of thrombotic events...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29628681/fallacies-of-ct-based-component-size-prediction-in-total-knee-arthroplasty-are-patient-specific-instruments-the-answer
#9
Raju Vaishya, Vipul Vijay, Midhun Krishnan, Amit K Agarwal
Background: The purpose of the study was to assess the accuracy of tibial and femoral component size prediction using computerised tomography (CT) based patient specific instruments in total knee arthroplasty. Methods: Eighty-eight knees in 58 patients underwent total knee arthroplasty (TKA) using CT based patient specific instruments between March 2015 to April 2016. All patients were assessed for the pre operative femoral and tibial component sizes predicted by the CT-based pre-operative plan...
January 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29621134/dosimetric-implications-of-computerised-tomography-only-versus-magnetic-resonance-fusion-contouring-in-stereotactic-body-radiotherapy-for-prostate-cancer
#10
Daniel R Henderson, Alison C Tree, Kevin J Harrington, Nicholas J van As
Background: Magnetic resonance (MR)-fusion contouring is the standard of care in prostate stereotactic body radiotherapy (SBRT) for target volume localisation. However, the planning computerised tomography (CT) scan continues to be used for dose calculation and treatment planning and verification. Discrepancies between the planning MR and CT scans may negate the benefits of MR-fusion contouring and it adds a significant resource burden. We aimed to determine whether CT-only contouring resulted in a dosimetric detriment compared with MR-fusion contouring in prostate SBRT planning...
April 5, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29594851/endocavitary-contrast-enhanced-ultrasound-ceus-a-novel-problem-solving-technique
#11
REVIEW
G T Yusuf, C Fang, D Y Huang, M E Sellars, A Deganello, P S Sidhu
Contrast-enhanced ultrasound (CEUS) is a technique that has developed as an adjunct to conventional ultrasound. CEUS offers a number of benefits over conventional axial imaging with computerised tomography and magnetic resonance imaging, primarily as a "beside" test, without ionising radiation or the safety concerns associated with iodinated/gadolinium-based contrast agents. Intravascular use of ultrasound contrast agents (UCAs) is widespread with extensive evidence for effective use. Despite this, the potential utility of UCAs in physiological and non-physiological cavities has not been fully explored...
March 28, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29589085/real-time-computerised-tomography-assisted-porous-tantalum-implant-in-arco-stage-i-ii-non-traumatic-osteonecrosis-of-the-femoral-head-minimum-five-year-follow-up
#12
Ruyin Hu, Pengfei Lei, Bo Li, Hao Liu, Xucheng Yang, Ting Wen, Yihe Hu, Xiaobin Tian
PURPOSES: This study was established to investigate the medium-term clinical effect of real-time CT assisted porous tantalum implant for the treatment of ARCO stage I-II non-traumatic osteonecrosis of the femoral head (ONFH). METHODS: This study comprised 24 ONFH patients (29 hips) who were treated with intra-operative real-time CT accurate rapid positioning assisted drilling decompression, lesion removal and porous tantalum implant. Harris score, VAS score and imaging in pre-operation and follow-up period were recorded...
March 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29577630/diagnostic-accuracy-of-diffusion-weighted-imaging-magnetic-resonance-imaging-compared-to-positron-emission-tomography-computed-tomography-in-evaluating-and-assessing-pathological-response-to-treatment-in-adult-patients-with-lymphoma-a-systematic-review
#13
REVIEW
John J Fitzpatrick, Miriam A Ryan, John F Bruzzi
The use of Positron emission tomography/computerised tomography (PET/CT) is well established in the staging and assessment of treatment response of lymphoma. Recent studies have suggested that whole body diffusion-weighted imaging -magnetic resonance imaging (WB-DW-MRI) may be an alternative to PET/CT in both staging and assessment of treatment response. A systematic review was performed to assess the ability of DW-MRI in the assessment of treatment response in lymphoma. Pubmed, Medline, Web of Science and Embase databases were queried for studies examining whole body DW-MRI compared to PET/CT in adult patients using a protocol of search terms...
March 25, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29558684/facial-preservation-following-extreme-mummification-shrunken-heads
#14
Tobias M R Houlton, Caroline Wilkinson
Shrunken heads are a mummification phenomenon unique to South America. Ceremonial tsantsa are ritually reduced heads from enemy victims of the Shuar, Achuar, Awajún (Aguaruna), Wampís (Huambisa), and Candoshi-Shapra cultures. Commercial shrunken heads are comparatively modern and fraudulently produced for the curio-market, often using stolen bodies from hospital mortuaries and graves. To achieve shrinkage and desiccation, heads undergo skinning, simmering (in water) and drying. Considering the intensive treatments applied, this research aims to identify how the facial structure can alter and impact identification using post-mortem depiction...
March 6, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29557549/-x-linked-adrenoleukodystrophy-with-an-atypical-radiological-pattern
#15
A Ulate-Campos, J Petanas-Argemi, M Rebollo-Polo, C Jou, C Sierra, J Armstrong, M C Fons-Estupina
INTRODUCTION: X-linked adrenoleukodystrophy (X-ALD) is the most frequent peroxisomal disease. It is due to a mutation in the ABCD1 gene. The loss of functioning of ABCD1 triggers ineffective beta oxidation of very long-chain fatty acids, which gives rise to an accumulation of these fatty acids. The typical alteration revealed in neuroimaging scans in the cerebral form is symmetrical periventricular demyelination with posterior location. CASE REPORT: We report the case of a 10-year-old boy with right spastic hemiparesis and subacute cognitive impairment...
April 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29557405/brain-abscess-following-dental-implant-placement-via-crestal-sinus-lift-a-case-report
#16
Yifat Manor, Adi A Garfunkel
PURPOSE: To describe a rare case of odontogenic brain abscess. MATERIALS AND METHODS: A healthy, 35-year-old male had two dental implants placed in a simultaneously augmented maxillary sinus. One implant failed and the patient developed a maxillary sinusitis that failed to improve following antibiotic treatment at home. The neglected sinus infection led to formation of a brain abscess. The patient was hospitalised only when he had pan sinusitis with neurological signs...
2018: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29541811/subchondral-fracture-begins-from-the-bone-resorption-area-in-osteonecrosis-of-the-femoral-head-a-micro-computerised-tomography-study
#17
Hidetoshi Hamada, Masaki Takao, Takashi Sakai, Nobuhiko Sugano
PURPOSE: For successful joint preservation in osteonecrosis of the femoral head (ONFH), it is important to understand the mechanism of collapse. The purpose of this study was to investigate the initiation of subchondral fracture in ONFH by using micro-CT imaging of the whole femoral head, focusing on the three-dimensional relationship between the subchondral fracture and the bone resorption area. METHODS: A total of 40 femoral heads from 37 patients retrieved during total hip arthroplasty for stage 3A or 3B ONFH by Japanese Investigation Committee criteria were scanned using micro-CT with a 0...
March 14, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29513925/what-imaging-detected-pathologies-are-associated-with-shoulder-symptoms-and-their-persistence-a-systematic-literature-review
#18
Gui Tran, Paul Cowling, Toby Smith, Julie Bury, Adam Lucas, Andrew Barr, Sarah R Kingsbury, Philip G Conaghan
OBJECTIVE: Shoulder symptoms are common and imaging is being increasingly used to help with management. However, the relationship between imaging and symptoms remain unclear. This review aims to understand the relationship between imaging-detected pathologies, symptoms and their persistence. METHODS: A systematic review using Medline, EMBASE, Cochrane and grey literature was conducted to April 2017. The cross-sectional and longitudinal relationships between imaging-detected abnormalities and symptoms were analysed and associations qualitatively characterised by a best evidence synthesis based on study design, covariate adjustment and the Grade of Recommendations Assessment, Development and Evaluation (GRADE)...
March 7, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29504574/calf-muscle-density-is-independently-associated-with-physical-function-in-overweight-and-obese-older-adults
#19
David Scott, Catherine Shore-Lorenti, Lachlan B McMillan, Jakub Mesinovic, Ross A Clark, Alan Hayes, Kerrie M Sanders, Gustavo Duque, Peter R Ebeling
OBJECTIVES: To determine whether associations of calf muscle density with physical function are independent of other determinants of functional decline in overweight and obese older adults. METHODS: This was a secondary analysis of a cross-sectional study of 85 community-dwelling overweight and obese adults (mean±SD age 62.8±7.9 years; BMI 32.3±6.1 kg/m2; 58% women). Peripheral quantitative computed tomography assessed mid-calf muscle density (66% tibial length) and dual-energy X-ray absorptiometry determined visceral fat area...
March 1, 2018: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/29396805/standardized-three-dimensional-computerised-tomography-scanner-reconstructions-increase-the-accuracy-of-acetabular-fracture-classification
#20
Amer Sebaaly, Guillaume Riouallon, Mourad Zaraa, Peter Upex, Véronique Marteau, Pomme Jouffroy
PURPOSE: Evaluate the role of four standardized 3D reconstruction views in the accurate diagnosis of acetabular fractures. MATERIALS AND METHODS: Thirty-five acetabular fracture cases were selected from a tertiary centre database. Fourteen reviewers with different experience level evaluated this set of images which were provided in axial 2D views and multiplanar reconstruction (MPR) without 3D views in the first two readings then the standardized 3D views were added for the subsequent two readings...
February 2, 2018: International Orthopaedics
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