Feng-Qi Liu, Qing-Yuan Qu, Ying Lei, Qi Chen, Yu-Xiu Chen, Meng-Lin Li, Xue-Yan Sun, Ye-Jun Wu, Qiu-Sha Huang, Hai-Xia Fu, Yuan Kong, Yue-Ying Li, Qian-Fei Wang, Xiao-Jun Huang, Xiao-Hui Zhang
To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight (CyTOF). Thirty-six patients with ITP and nine healthy volunteers were enrolled in the study. As soluble immunomodulatory molecules, more sCD25 and sGalectin-9 were detected in ITP patients. On the cell surface, co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T cells...
April 19, 2024: Science China. Life Sciences