Tianhao Yu, Lili Wen, Jing He, Yingxi Xu, Ting Li, Weizuo Wang, Yizhan Ma, Muhammad Arslan Ahmad, Xiaohong Tian, Jun Fan, Xiaohong Wang, Haruo Hagiwara, Qiang Ao
Acellular nerve allografts are promising alternatives to autologous nerve grafts, but still have many drawbacks which greatly limit their curative effects. Here, we developed an optimized acellular nerve allograft with multiple axial channels by a modified decellularization method. These allografts were confirmed to preserve more extracellular matrix components and factors, and remove cellular components effectively. Meanwhile, macrochannels and microchannels were introduced to optimize internal microstructure of allografts, which increases porosity and water absorption, without significant loss of mechanical strength...
August 6, 2020: Acta Biomaterialia