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4 dimensional printing

Zhongmin Wang, Yuhao Liu, Yu Xu, Chuanyu Gao, Yan Chen, Hongxing Luo
BACKGROUND: WE AIMED TO PROSPECTIVELY EVALUATE THE: use of 3-dimensional printing (3DP) for the percutaneous transcatheter closure of a secundum atrial septal defect (ASD) with rim deficiency less than 5 mm. METHODS: Patients with ASD were scanned using multi-slice computed tomography to acquire raw data for virtual 3DP reconstruction models. Different ASD occluders were tried on the 3DP models to select the optimal size for intraoperative use. The patients were followed up 1 month postoperatively, and 3DP models were again manufactured to observe the operative effects...
October 17, 2016: Cardiology Journal
Thorsten Jentzsch, Lazaros Vlachopoulos, Philipp Fürnstahl, Daniel A Müller, Bruno Fuchs
BACKGROUND: Sarcomas are associated with a relatively high local recurrence rate of around 30 % in the pelvis. Inadequate surgical margins are the most important reason. However, obtaining adequate margins is particularly difficult in this anatomically demanding region. Recently, three-dimensional (3-D) planning, printed models, and patient-specific instruments (PSI) with cutting blocks have been introduced to improve the precision during surgical tumor resection. This case series illustrates these modern 3-D tools in pelvic tumor surgery...
September 21, 2016: World Journal of Surgical Oncology
Wenjing Su, Benjamin S Cook, Yunnan Fang, Manos M Tentzeris
As the needs for low-cost rapidly-produced microfluidics are growing with the trend of Lab-on-a-Chip and distributed healthcare, the fully inkjet-printing of microfluidics can be a solution to it with numerous potential electrical and sensing applications. Inkjet-printing is an additive manufacturing technique featuring no material waste and a low equipment cost. Moreover, similar to other additive manufacturing techniques, inkjet-printing is easy to learn and has a high fabrication speed, while it offers generally a great planar resolution down to below 20 µm and enables flexible designs due to its inherent thin film deposition capabilities...
October 7, 2016: Scientific Reports
Michel P Bonnin, Tom Van Hoof, Arnoud De Kok, Matthias Verstraete, Catherine Van der Straeten, Moreno Saffarini, Jan Victor
BACKGROUND: In Total Knee Arthroplasty (TKA), residual pain may be secondary to soft tissue impingements, which are difficult to visualize around chromium-cobalt implants using medical imaging, so their interactions remain poorly understood. The goal of this work was to establish a protocol for in-vitro imaging of the soft tissues around TKA, usable during throughout the range of motion (ROM). METHODS: The full size range of a commercially available TKA prosthesis was manufactured by 3D-printing in non-magnetic and non-radiopaque polymer and implanted in 12 cadaveric knees...
December 2016: Journal of Experimental Orthopaedics
Milena Nadgorny, Zeyun Xiao, Chao Chen, Luke A Connal
In this work we describe the synthesis, thermal and rheological characterization, hot-melt extrusion and three-dimensional printing (3DP) of poly(2-vinylpyridine) (P2VP). We investigate the effect of thermal processing conditions on physical properties of produced filaments in order to achieve high quality, 3D- printable filaments for fused deposition modeling (FDM). We 3D-print P2VP filaments using an affordable 3D printer. The pyridine moieties are crosslinked and quaternized post-printing to form 3D-printed pH-responsive hydrogels...
October 3, 2016: ACS Applied Materials & Interfaces
Yuanyuan Sun, Xucong Ruan, Hairui Li, Himanshu Kathuria, Guang Du, Lifeng Kang
Conventional suppositories sometimes fail in exerting their therapeutic activity as the base materials melt inside body cavities. Also they are not suitable to provide long term treatment. Biomedical grade silicone elastomers may be used to fabricate non-dissolvable suppositories to overcome these disadvantages. We kneaded 4 analgesics into the 2 kinds of silicone polymers at 1%, 5% and 10% drug loading, respectively, to test their mechanical properties and drug release profiles. The optimized drug-polymer combinations were used to fabricate suppositories, and three dimensional printing (3DP) was used to create the suppository moulds...
September 26, 2016: International Journal of Pharmaceutics
Lei Gao, Yuxia Gao, Yuan Lin, Yong Ju, Song Yang, Jun Hu
In this research a dual-component charge-transfer (CT) induced supramolecular hydrogel was fabricated using pyrene-tailored pyridinium (PYP) and 2,4,7-trinitrofluorenone (TNF) as the electron donor and acceptor, respectively. Its thermal stability and mechanical property have been modulated effectively by altering the concentration or molar ratio of PYP and TNF. Moreover, this CT-hydrogel exhibited a distinct injectable self-healing property, which could be utilized to create desired patterns on substrates...
September 29, 2016: Chemistry, An Asian Journal
Adam E Jakus, Alexandra L Rutz, Sumanas W Jordan, Abhishek Kannan, Sean M Mitchell, Chawon Yun, Katie D Koube, Sung C Yoo, Herbert E Whiteley, Claus-Peter Richter, Robert D Galiano, Wellington K Hsu, Stuart R Stock, Erin L Hsu, Ramille N Shah
Despite substantial attention given to the development of osteoregenerative biomaterials, severe deficiencies remain in current products. These limitations include an inability to adequately, rapidly, and reproducibly regenerate new bone; high costs and limited manufacturing capacity; and lack of surgical ease of handling. To address these shortcomings, we generated a new, synthetic osteoregenerative biomaterial, hyperelastic "bone" (HB). HB, which is composed of 90 weight % (wt %) hydroxyapatite and 10 wt % polycaprolactone or poly(lactic-co-glycolic acid), could be rapidly three-dimensionally (3D) printed (up to 275 cm(3)/hour) from room temperature extruded liquid inks...
September 28, 2016: Science Translational Medicine
Joshua L Hermsen, Thomas M Burke, Stephen P Seslar, David S Owens, Beth A Ripley, Nahush A Mokadam, Edward D Verrier
OBJECTIVE: Static 3-dimensional printing is used for operative planning in cases that involve difficult anatomy. An interactive 3D print allowing deliberate surgical practice would represent an advance. METHODS: Two patients with hypertrophic cardiomyopathy had 3-dimensional prints constructed preoperatively. Stereolithography files were generated by segmentation of chest computed tomographic scans. Prints were made with hydrogel material, yielding tissue-like models that can be surgically manipulated...
August 20, 2016: Journal of Thoracic and Cardiovascular Surgery
N Zeng, C H Fang, Y F Fan, J Yang, N Xiang, W Zhu, J Liu, W Cai, Z K Mo
OBJECTIVE: To explore the construction and clinical efficacy of three-dimensional(3D) visualization platform about diagnosis and treatment of hilar cholangiocarcinoma. METHODS: From January 2009 to December 2015, a total of 32 patients with hilarcholangiocarcinoma treated in Zhujiang Hospital of Southern Medical University were analyzed.There were 20 male and 12 female patients aged from 40 to 85 years. Bismuth-Corlette 3D visualization type: 2 cases with type Ⅰ, 5 cases with type Ⅱ, 10 cases with type Ⅲa, 11 cases with type Ⅲb, 4 cases with type Ⅳ...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Yan Wang, Hong Guo, Jin-Ju Chen, Enrico Sowade, Yu Wang, Kun Liang, Kyle Marcus, Reinhard R Baumann, Zhe-Sheng Feng
Printed flexible electronics have been widely studied for their potential use in various applications. In this paper, a simple, low-cost method of fabricating flexible electronic circuits with high conductivity of 4.0 × 10(7) S·m(-1) (about 70% of the conductivity of bulk copper) is demonstrated. Teslin paper substrate is treated with stannous chloride (SnCl2) colloidal solution to reduce the high ink absorption rate, and then the catalyst ink is inkjet-printed on its surface, followed by electroless deposition of copper at low temperature...
October 5, 2016: ACS Applied Materials & Interfaces
Yuwadee Boonyasit, Orawon Chailapakul, Wanida Laiwattanapaisal
A novel three-dimensional paper-based electrochemical impedance device (3D-PEID) is first introduced for measuring multiple diabetes markers. Herein, a simple 3D-PEID composed of a dual screen-printed electrode on wax-patterned paper coupled with a multilayer of magnetic paper was fabricated for label-free electrochemical detection. The results clearly demonstrated in a step-wise manner that the haptoglobin (Hp)-modified and 3-aminophenylboronic acid (APBA)-modified eggshell membranes (ESMs) were highly responsive to a clinically relevant range of total (0...
September 14, 2016: Analytica Chimica Acta
Ruchi Mishra, Ryan S Sefcik, Tyler J Bishop, Stefani M Montelone, Nisha Crouser, Jean F Welter, Arnold I Caplan, David Dean
One approach to the development of an artificial graft material could rely on uniform coverage of a resorbable biomaterial with bone extracellular matrix (ECM). To achieve this on the surface of poly(propylene fumarate) (PPF) scaffolds, we selected a growth factor regime of basic fibroblast growth factor (FGF-2) (5 ng/mL), platelet-derived growth factor (PDGF-BB) (40 ng/mL), and epidermal growth factor (EGF) (20 ng/mL) to stimulate proliferation of bone marrow-derived human mesenchymal stem cells (BM-hMSCs)...
September 2016: Tissue Engineering. Part C, Methods
Toshiaki Numajiri, Hiroko Nakamura, Yoshihiro Sowa, Kenichi Nishino
BACKGROUND: Surgical cutting guides are used in mandibular reconstruction involving osteotomy of the mandible and fibula. Cutting guides produced using computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies have been reported recently. These guides aim to increase the benefits to patients by improving the accuracy, shortening the operating time, and correcting occlusion. However, the availability of these advanced technologies is limited in some regions of the world...
July 2016: Plastic and Reconstructive Surgery. Global Open
Zeynep Onerci Altunay, Joseph A Bly, Philip K Edwards, David R Holmes, Grant S Hamilton, Erin K O'Brien, Alan B Carr, Jon J Camp, Janalee K Stokken, John F Pallanch
BACKGROUND: Since 1972, patients with large nasal perforations, who were symptomatic, and who were not candidates for surgery, had the option of custom prosthetic closure at Mayo Clinic. Although septal prostheses have helped many patients, 27% of pre-1982 patients chose not to keep the prosthesis in place. Two-dimensional computed tomography (CT) sizing resulted in more of the patients choosing to retain the prosthesis. The introduction of three-dimensional (3-D) printing to the sizing process offered the potential of further improved retention by refinement in prosthesis fit...
July 2016: American Journal of Rhinology & Allergy
Taku Sugawara, Naoki Higashiyama, Shuichi Kaneyama, Masatoshi Sumi
STUDY DESIGN: Prospective clinical trial of the screw insertion method for posterior C1-C2 fixation utilizing the patient-specific screw guide template technique. OBJECTIVE: To evaluate the efficacy of this method for insertion of C1 lateral mass screws (LMS), C2 pedicle screws (PS), and C2 laminar screws (LS). SUMMARY OF BACKGROUND DATA: Posterior C1LMS and C2PS fixation, also known as the Goel-Harms method, can achieve immediate rigid fixation and high fusion rate, but the screw insertion carries the risk of injury to neuronal and vascular structures...
July 22, 2016: Spine
Samuel J Rowley-Neale, Jamie M Fearn, Dale A C Brownson, Graham C Smith, Xiaobo Ji, Craig E Banks
Two-dimensional molybdenum disulphide nanosheets (2D-MoS2) have proven to be an effective electrocatalyst, with particular attention being focused on their use towards increasing the efficiency of the reactions associated with hydrogen fuel cells. Whilst the majority of research has focused on the Hydrogen Evolution Reaction (HER), herein we explore the use of 2D-MoS2 as a potential electrocatalyst for the much less researched Oxygen Reduction Reaction (ORR). We stray from literature conventions and perform experiments in 0...
August 21, 2016: Nanoscale
Shuai Leng, Baiyu Chen, Thomas Vrieze, Joel Kuhlmann, Lifeng Yu, Amy Alexander, Jane Matsumoto, Jonathan Morris, Cynthia H McCollough
The purpose of this study was to use three-dimensional (3-D) printing techniques to construct liver and brain phantoms having realistic pathologies, anatomic structures, and heterogeneous backgrounds. Patient liver and head computed tomography (CT) images were segmented into tissue, vessels, liver lesion, white and gray matter, and cerebrospinal fluid (CSF). Stereolithography files of each object were created and imported into a commercial 3-D printer. Printing materials were assigned to each object after test scans, which showed that the printing materials had CT numbers ranging from 70 to 121 HU at 120 kV...
July 2016: Journal of Medical Imaging
Guoxian Chen, Guoshan Li, Zongjin Lin, Xuanhuang Chen, Zhen Weng, Guosong Xu, Zeng Qingdong, Zugao Zheng, Guodong Zhang, Zhengxi Yu
OBJECTIVE: To evaluate the effectiveness of high tibial osteotomy (HTO) assisted by three-dimensional (3-D) printing technology for correction of varus knee with osteoarthritis. METHODS: Between January 2014 and June 2015, 16 patients (20 knees) with varus knee and osteoarthritis underwent HTO assisted by 3-D printing technology; a locking compression plate was used for internal fixation after HTO. There were 6 males and 10 females, aged 30-60 years (mean, 45.5 years)...
April 2016: Chinese Journal of Reparative and Reconstructive Surgery
Jian-Ru Xiao, Wen-Ding Huang, Xing-Hai Yang, Wang-Jun Yan, Dian-Wen Song, Hai-Feng Wei, Tie-Long Liu, Zhi-Peng Wu, Cheng Yang
OBJECTIVE: To investigate the feasibility and safety of en bloc resection of cervical primary malignant bone tumors by a combined anterior and posterior approach based on a three-dimensional (3-D) printing model. METHODS: Five patients with primary malignant bone tumors of the cervical spine underwent en bloc resection via a one-stage combined anteroposterior approach in our hospital from March 2013 to June 2014. They comprised three men and two women of mean age 47...
May 2016: Orthopaedic Surgery
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