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https://www.readbyqxmd.com/read/29732197/multi-dimensional-printing-in-thoracic-surgery-current-and-future-applications
#1
REVIEW
Jackson K S Kwok, Rainbow W H Lau, Ze-Rui Zhao, Peter S Y Yu, Jacky Y K Ho, Simon C Y Chow, Innes Y P Wan, Calvin S H Ng
Three-dimensional (3D) printing has been gaining much attention in the medical field in recent years. At present, 3D printing most commonly contributes in pre-operative surgical planning of complicated surgery. It is also utilized for producing personalized prosthesis, well demonstrated by the customized rib cage, vertebral body models and customized airway splints. With on-going research and development, it will likely play an increasingly important role across the surgical fields. This article reviews current application of 3D printing in thoracic surgery and also provides a brief overview on the extended and updated use of 3D printing in bioprinting and 4D printing...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29691816/synthetic-materials-for-osteochondral-tissue-engineering
#2
Antoniac Iulian, Laptoiu Dan, Tecu Camelia, Milea Claudia, Gradinaru Sebastian
The objective of an articular cartilage repair treatment is to repair the affected surface of an articular joint's hyaline cartilage. Currently, both biological and tissue engineering research is concerned with discovering the clues needed to stimulate cells to regenerate tissues and organs totally or partially. The latest findings on nanotechnology advances along with the processability of synthetic biomaterials have succeeded in creating a new range of materials to develop into the desired biological responses to the cellular level...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29651999/photolithographic-stereolithographic-tandem-fabrication-of-4d-smart-scaffolds-for-improved-stem-cell-cardiomyogenic-differentiation
#3
Shida Miao, Haitao Cui, Margaret Nowicki, Se-Jun Lee, Jose Almeida, Xuan Zhou, Wei Zhu, Xiaoliang Yao, Fahed Masood, Michael W Plesniak, Muhammad Mohiuddin, Lijie Grace Zhang
4D printing is a highly innovative additive manufacturing process for fabricate smart structures with the ability to transform over time. Significantly different from regular 4D printing techniques, this study focuses on creating novel 4D hierarchical micropatterns using a unique photolithographic-stereolithographic-tandem strategy (PSTS) with smart soybean oil epoxidized acrylate (SOEA) inks for effectively regulating human bone marrow mesenchymal stem cell (hMSC) cardiomyogenic behaviors. The 4D effect refers to autonomous conversion of the surficial-patterned scaffold into a pre-designed construct through an external stimulus delivered immediately after printing...
April 13, 2018: Biofabrication
https://www.readbyqxmd.com/read/29510503/design-and-4d-printing-of-cross-folded-origami-structures-a-preliminary-investigation
#4
Joanne Ee Mei Teoh, Jia An, Xiaofan Feng, Yue Zhao, Chee Kai Chua, Yong Liu
In 4D printing research, different types of complex structure folding and unfolding have been investigated. However, research on cross-folding of origami structures (defined as a folding structure with at least two overlapping folds) has not been reported. This research focuses on the investigation of cross-folding structures using multi-material components along different axes and different horizontal hinge thickness with single homogeneous material. Tensile tests were conducted to determine the impact of multi-material components and horizontal hinge thickness...
March 3, 2018: Materials
https://www.readbyqxmd.com/read/29493213/nanoclay-based-self-supporting-responsive-nanocomposite-hydrogels-for-printing-applications
#5
Yifei Jin, Yangyang Shen, Jun Yin, Jin Qian, Yong Huang
Stimuli-responsive hydrogels and/or composite hydrogels have been of great interest for various printing applications including four-dimensional printing. Although various responsive hydrogels and/or composite hydrogels have been found to respond to given stimuli and change shapes as designed, the fabrication of three-dimensional (3D) structures from such responsive hydrogels is still a challenge due to their poor 3D printability, and most of the responsive material-based patterns are two-dimensional (2D) in nature...
March 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29403328/4d-printing-of-polymeric-materials-for-tissue-and-organ-regeneration
#6
Shida Miao, Nathan Castro, Margaret Nowicki, Lang Xia, Haitao Cui, Xuan Zhou, Wei Zhu, Se-Jun Lee, Kausik Sarkar, Giovanni Vozzi, Yasuhiko Tabata, John Fisher, Lijie Grace Zhang
Four dimensional (4D) printing is an emerging technology with great capacity for fabricating complex, stimuli-responsive 3D structures, providing great potential for tissue and organ engineering applications. Although the 4D concept was first highlighted in 2013, extensive research has rapidly developed, along with more-in-depth understanding and assertions regarding the definition of 4D. In this review, we begin by establishing the criteria of 4D printing, followed by an extensive summary of state-of-the-art technological advances in the field...
December 2017: Materials Today
https://www.readbyqxmd.com/read/29400445/3d-printing-of-highly-stretchable-shape-memory-and-self-healing-elastomer-toward-novel-4d-printing
#7
Xiao Kuang, Kaijuan Chen, Conner K Dunn, Jiangtao Wu, Vincent C F Li, H Jerry Qi
The three-dimensional (3D) printing of flexible and stretchable materials with smart functions such as shape memory (SM) and self-healing (SH) is highly desirable for the development of future 4D printing technology for myriad applications, such as soft actuators, deployable smart medical devices, and flexible electronics. Here, we report a novel ink that can be used for the 3D printing of highly stretchable, SM, and SH elastomer via UV-light-assisted direct-ink-write printing. An ink containing urethane diacrylate and a linear semicrystalline polymer is developed for the 3D printing of a semi-interpenetrating polymer network elastomer that can be stretched by up to 600%...
February 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29361754/advanced-material-strategies-for-next-generation-additive-manufacturing
#8
REVIEW
Jinke Chang, Jiankang He, Mao Mao, Wenxing Zhou, Qi Lei, Xiao Li, Dichen Li, Chee-Kai Chua, Xin Zhao
Additive manufacturing (AM) has drawn tremendous attention in various fields. In recent years, great efforts have been made to develop novel additive manufacturing processes such as micro-/nano-scale 3D printing, bioprinting, and 4D printing for the fabrication of complex 3D structures with high resolution, living components, and multimaterials. The development of advanced functional materials is important for the implementation of these novel additive manufacturing processes. Here, a state-of-the-art review on advanced material strategies for novel additive manufacturing processes is provided, mainly including conductive materials, biomaterials, and smart materials...
January 22, 2018: Materials
https://www.readbyqxmd.com/read/29302670/4d-printing-of-a-self-morphing-polymer-driven-by-a-swellable-guest-medium
#9
Jheng-Wun Su, Xiang Tao, Heng Deng, Cheng Zhang, Shan Jiang, Yuyi Lin, Jian Lin
There is a significant need of advanced materials that can be fabricated into functional devices with defined three-dimensional (3D) structures for application in tissue engineering, flexible electronics, and soft robotics. This need motivates an emerging four-dimensional (4D) printing technology, by which printed 3D structures consisting of active materials can transform their configurations over time in response to stimuli. Despite the ubiquity of active materials in performing self-morphing processes, their potential for 4D printing has not been fully explored to date...
January 31, 2018: Soft Matter
https://www.readbyqxmd.com/read/29300738/hemodynamics-in-a-giant-intracranial-aneurysm-characterized-by-in-vitro-4d-flow-mri
#10
Omid Amili, Daniele Schiavazzi, Sean Moen, Bharathi Jagadeesan, Pierre-François Van de Moortele, Filippo Coletti
Experimental and computational data suggest that hemodynamics play a critical role in the development, growth, and rupture of cerebral aneurysms. The flow structure, especially in aneurysms with a large sac, is highly complex and three-dimensional. Therefore, volumetric and time-resolved measurements of the flow properties are crucial to fully characterize the hemodynamics. In this study, phase-contrast Magnetic Resonance Imaging is used to assess the fluid dynamics inside a 3D-printed replica of a giant intracranial aneurysm, whose hemodynamics was previously simulated by multiple research groups...
2018: PloS One
https://www.readbyqxmd.com/read/29210486/4d-printed-actuators-with-soft-robotic-functions
#11
María López-Valdeolivas, Danqing Liu, Dick Jan Broer, Carlos Sánchez-Somolinos
Soft matter elements undergoing programed, reversible shape change can contribute to fundamental advance in areas such as optics, medicine, microfluidics, and robotics. Crosslinked liquid crystalline polymers have demonstrated huge potential to implement soft responsive elements; however, the complexity and size of the actuators are limited by the current dominant thin-film geometry processing toolbox. Using 3D printing, stimuli-responsive liquid crystalline elastomeric structures are created here. The printing process prescribes a reversible shape-morphing behavior, offering a new paradigm for active polymer system preparation...
March 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29182541/ceramic-based-4d-components-additive-manufacturing-am-of-ceramic-based-functionally-graded-materials-fgm-by-thermoplastic-3d-printing-t3dp
#12
Uwe Scheithauer, Steven Weingarten, Robert Johne, Eric Schwarzer, Johannes Abel, Hans-Jürgen Richter, Tassilo Moritz, Alexander Michaelis
In our study, we investigated the additive manufacturing (AM) of ceramic-based functionally graded materials (FGM) by the direct AM technology thermoplastic 3D printing (T3DP). Zirconia components with varying microstructures were additively manufactured by using thermoplastic suspensions with different contents of pore-forming agents (PFA), which were co-sintered defect-free. Different materials were investigated concerning their suitability as PFA for the T3DP process. Diverse zirconia-based suspensions were prepared and used for the AM of single- and multi-material test components...
November 28, 2017: Materials
https://www.readbyqxmd.com/read/29024044/4d-biofabrication-using-shape-morphing-hydrogels
#13
Alina Kirillova, Ridge Maxson, Georgi Stoychev, Cheryl T Gomillion, Leonid Ionov
Despite the tremendous potential of bioprinting techniques toward the fabrication of highly complex biological structures and the flourishing progress in 3D bioprinting, the most critical challenge of the current approaches is the printing of hollow tubular structures. In this work, an advanced 4D biofabrication approach, based on printing of shape-morphing biopolymer hydrogels, is developed for the fabrication of hollow self-folding tubes with unprecedented control over their diameters and architectures at high resolution...
December 2017: Advanced Materials
https://www.readbyqxmd.com/read/28967260/four-dimensional-printing-of-liquid-crystal-elastomers
#14
Cedric P Ambulo, Julia J Burroughs, Jennifer M Boothby, Hyun Kim, M Ravi Shankar, Taylor H Ware
Three-dimensional structures capable of reversible changes in shape, i.e., four-dimensional-printed structures, may enable new generations of soft robotics, implantable medical devices, and consumer products. Here, thermally responsive liquid crystal elastomers (LCEs) are direct-write printed into 3D structures with a controlled molecular order. Molecular order is locally programmed by controlling the print path used to build the 3D object, and this order controls the stimulus response. Each aligned LCE filament undergoes 40% reversible contraction along the print direction on heating...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28961100/an-mri-compatible-hydrodynamic-simulator-of-cerebrospinal-fluid-motion-in-the-cervical-spine
#15
Suraj Thyagaraj, Soroush H Pahlavian, Lucas R Sass, Francis Loth, Morteza Vatani, Jao-Won Choi, R Shane Tubbs, Daniel Giese, Jan-Robert Kroger, Alexander C Bunck, Bryn A Martin
GOAL: Develop and test an MRI-compatible hydrodynamic simulator of cerebrospinal fluid (CSF) motion in the cervical spinal subarachnoid space. Four anatomically realistic subject-specific models were created based on a 22-year-old healthy volunteer and a five-year-old patient diagnosed with Chiari I malformation. METHODS: The in vitro models were based on manual segmentation of high-resolution T2-weighted MRI of the cervical spine. Anatomically realistic dorsal and ventral spinal cord nerve rootlets (NR) were added...
September 26, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28877531/towards-individualized-tracheobronchial-stents-technical-practical-and-legal-considerations
#16
Lutz Freitag, Martin Gördes, Paul Zarogoulidis, Kaid Darwiche, Daniel Franzen, Faustina Funke, Wolfgang Hohenforst-Schmidt, Hervé Dutau
Stent placement has been established as a standard procedure for treating airway obstructions. Other indications are localized malacias and fistulas. Though many different stents with various diameters and lengths are available, the shapes are hardly ever ideal because of the distorted anatomy in patients with diseased airways. There are technical and legal limitations for customizing purchased airway stents. Individually tailored stents would be preferable. New techniques of additive manufacturing such as 3D printing make it possible to produce optimized stents for a particular patient...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28771375/recent-development-and-biomedical-applications-of-self-healing-hydrogels
#17
Yinan Wang, Christian K Adokoh, Ravin Narain
Hydrogels are of special importance, owing to their high-water content and various applications in biomedical and bio-engineering research. Self-healing properties is a common phenomenon in living organisms. Their endowed property of being able to self-repair after physical/chemical/mechanical damage to fully or partially its original properties demonstrates their prospective therapeutic applications. Due to complicated preparation and selection of suitable materials, the application of many host-guest supramolecular polymeric hydrogels are so limited...
January 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28766726/a-novel-3d-printed-phantom-insert-for-4d-pet-ct-imaging-and-simultaneous-integrated-boost-radiotherapy
#18
Laura Cerviño, Dima Soultan, Mariel Cornell, Adam Yock, Niclas Pettersson, William Y Song, Joseph Aguilera, Sunil Advani, James Murphy, Carl Hoh, Claude James, Anthony Paravati, Robin Coope, Bradford Gill, Vitali Moiseenko
PURPOSE: To construct a 3D-printed phantom insert designed to mimic the variable PET tracer uptake seen in lung tumor volumes and a matching dosimetric insert to be used in simultaneous integrated boost (SIB) phantom studies, and to evaluate the design through end-to-end tests. METHODS: A set of phantom inserts was designed and manufactured for a realistic representation of gated radiotherapy steps from 4D PET/CT scanning to dose delivery. A cylindrical phantom (φ80 × 120 mm) holds inserts for PET/CT scanning...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/28759164/4d-origami-by-smart-embroidery
#19
Georgi Stoychev, Mir Jalil Razavi, Xianqiao Wang, Leonid Ionov
There exist many methods for processing of materials: extrusion, injection molding, fibers spinning, 3D printing, to name a few. In most cases, materials with a static, fixed shape are produced. However, numerous advanced applications require customized elements with reconfigurable shape. The few available techniques capable of overcoming this problem are expensive and/or time-consuming. Here, the use of one of the most ancient technologies for structuring, embroidering, is proposed to generate sophisticated patterns of active materials, and, in this way, to achieve complex actuation...
July 31, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28726680/towards-4d-printed-scaffolds-for-tissue-engineering-exploiting-3d-shape-memory-polymers-to-deliver-time-controlled-stimulus-on-cultured-cells
#20
Wilhelmus J Hendrikson, Jeroen Rouwkema, Federico Clementi, Clemens A van Blitterswijk, Silvia Farè, Lorenzo Moroni
Tissue engineering needs innovative solutions to better fit the requirements of a minimally invasive approach, providing at the same time instructive cues to cells. The use of shape memory polyurethane has been investigated by producing 4D scaffolds via additive manufacturing technology. Scaffolds with two different pore network configurations (0/90° and 0/45°) were characterized by dynamic-mechanical analysis. The thermo-mechanical analysis showed a Tg at about 32 °C (Tg = T trans), indicating no influence of the fabrication process on the transition temperature...
August 2, 2017: Biofabrication
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