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https://www.readbyqxmd.com/read/28078588/boyden-chamber-assay-to-study-of-cell-migration-induced-by-metalloprotease-cleaved-cd95l
#1
Amanda Poissonnier, Patrick Legembre
CD95 receptor, also called Fas or Apo-1, is a member of the tumor necrosis factor receptors (TNF-R) superfamily (Itoh and Nagata, J Biol Chem 268:10932-10937, 1993). Its cognate ligand, CD95L, is a transmembrane cytokine, which can be cleaved by metalloproteases (Matsuno et al., J Rheumatol 28:22-28, 2001; Vargo-Gogola et al., Arch Biochem Biophys 408:155-161, 2002; Kiaei et al., Exp Neurol 205:74-81, 2007; Schulte et al., Cell Death Differ 14:1040-1049, 2007) releasing a soluble ligand into the bloodstream...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28017245/corrigendum-to-role-of-neurodevelopment-involved-genes-in-psychiatric-comorbidities-and-modulation-of-inflammatory-processes-in-alzheimer-s-disease-j-neurol-sci-370-november-2016-162-166
#2
Stefano Porcelli, Concetta Crisafulli, Luigi Donato, Marco Calabrò, Antonis Politis, Ioannis Liappas, Diego Albani, Anna Rita Atti, Raffaele Salfi, Ilaria Raimondi, Gianluigi Forloni, George N Papadimitriou, Diana De Ronchi, Alessandro Serretti
No abstract text is available yet for this article.
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017212/corrigendum-to-sexual-dysfunction-in-multiple-sclerosis-a-6-year-follow-up-study-j-neurol-sci-358-2015-317-323
#3
Darija Kisic-Tepavcevic, Tatjana Pekmezovic, Goran Trajkovic, Nebojsa Stojsavljevic, Irena Dujmovic, Sarlota Mesaros, Jelena Drulovic
No abstract text is available yet for this article.
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28012021/lentiviral-modulation-of-wnt-%C3%AE-catenin-signaling-affects-in-vivo-ltp
#4
Olga Ya Ivanova, Yulia V Dobryakova, Sergey V Salozhin, Viktor A Aniol, Mikhail V Onufriev, Natalia V Gulyaeva, Vladimir A Markevich
Wnt signaling is involved in hippocampal development and synaptogenesis. Numerous recent studies have been focused on the role of Wnt ligands in the regulation of synaptic plasticity. Inhibitors and activators of canonical Wnt signaling were demonstrated to decrease or increase, respectively, in vitro long-term potentiation (LTP) maintenance in hippocampal slices (Chen et al. in J Biol Chem 281:11910-11916, 2006; Vargas et al. in J Neurosci 34:2191-2202, 2014, Vargas et al. in Exp Neurol 264:14-25, 2015). Using lentiviral approach to down- and up-regulate the canonical Wnt signaling, we explored whether Wnt/β-catenin signaling is critical for the in vivo LTP...
December 23, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28001316/computed-tomography-based-quantification-of-lesion-water-uptake-identifies-patients-within-4-5-hours-of-stroke-onset-a-multicenter-observational-study
#5
Jens Minnerup, Gabriel Broocks, Judith Kalkoffen, Soenke Langner, Michael Knauth, Marios Nikos Psychogios, Heike Wersching, Anja Teuber, Walter Heindel, Bernd Eckert, Heinz Wiendl, Peter Schramm, Jens Fiehler, André Kemmling
OBJECTIVE: Many patients with stroke cannot receive intravenous thrombolysis because the time of symptom onset is unknown. We tested whether computed tomography (CT)-based quantification of water uptake in the ischemic tissue can identify patients with stroke onset within 4.5 hours, the time window of thrombolysis. METHODS: Perfusion CT was used to identify ischemic brain tissue, and its density was measured in native CT and related to the density of the corresponding area of the contralateral hemisphere to quantify lesion water uptake...
December 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27997067/rotenone-and-elevated-extracellular-potassium-concentration-induce-cell-specific-fibrillation-of-%C3%AE-synuclein-in-axons-of-cholinergic-enteric-neurons-in-the-guinea-pig-ileum
#6
D F Sharrad, B N Chen, W P Gai, N Vaikath, O M El-Agnaf, S J H Brookes
BACKGROUND: Parkinson's disease is a progressive neurodegenerative disorder that results in the widespread loss of select classes of neurons throughout the nervous system. The pathological hallmarks of Parkinson's disease are Lewy bodies and neurites, of which α-synuclein fibrils are the major component. α-Synuclein aggregation has been reported in the gut of Parkinson's disease patients, even up to a decade before motor symptoms, and similar observations have been made in animal models of disease...
November 7, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27919467/erratum-to-brain-connectivity-and-auditory-hallucinations-in-search-of-novel-noninvasive-brain-stimulation-therapeutic-approaches-for-schizophrenia-rev-neurol-159-11-2016
#7
F Thomas, V Moulier, A Valero-Cabré, D Januel
No abstract text is available yet for this article.
December 2, 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27917533/human-spinal-ejaculation-generator
#8
Clément Chéhensse, Patricia Facchinetti, Stéphane Bahrami, Philippe Andrey, Jean-Marc Soler, Fabrice Chrétien, Jacques Bernabé, Pierre Clément, Pierre Denys, François Giuliano
OBJECTIVE: A spinal ejaculation generator (SEG) has been identified in the rat with lumbar galaninergic interneurons playing a pivotal role (Science 2002;297:1566-1569). The aim was to evidence a SEG in humans. METHODS: Spatial distribution of galaninergic neurons was studied in postmortem spinal cord segments of 6 men and compared with that of 6 women for evidencing sexual dimorphism. Based on the identified segmental distribution of galaninergic neurons, the ability for penile vibratory stimulation (PVS) to elicit ejaculation when the concerned spinal segments were injured was studied in 384 patients with clinically complete spinal cord injury (SCI) and consequent anejaculation...
December 5, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27871439/corrigendum-to-mortality-of-advanced-parkinson-s-disease-patients-treated-with-deep-brain-stimulation-surgery-j-neurol-sci-369-230-235
#9
Sun Ju Chung
No abstract text is available yet for this article.
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27862206/malformations-of-cortical-development
#10
REVIEW
Rahul S Desikan, A James Barkovich
Malformations of cortical development (MCDs) compose a diverse range of disorders that are common causes of neurodevelopmental delay and epilepsy. With improved imaging and genetic methodologies, the underlying molecular and pathobiological characteristics of several MCDs have been recently elucidated. In this review, we discuss genetic and molecular alterations that disrupt normal cortical development, with emphasis on recent discoveries, and provide detailed radiological features of the most common and important MCDs...
December 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27859541/ambroxol-effects-in-glucocerebrosidase-and-%C3%AE-synuclein-transgenic-mice
#11
Anna Migdalska-Richards, Liam Daly, Erwan Bezard, Anthony H V Schapira
OBJECTIVE: Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small molecule chaperone that has been shown to increase glucocerebrosidase activity in vitro. This study investigated the effect of ambroxol treatment on glucocerebrosidase activity and on α-synuclein and phosphorylated α-synuclein protein levels in mice...
November 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27817964/corrigendum-to-simultaneous-multisystem-surgery-an-important-capability-for-the-civilian-trauma-hospital-clin-neurol-neurosurg-148-2016-13-16
#12
Justin M Moore, Piers A W Thomas, Russell L Gruen, Patrick Chan, Jeffrey V Rosenfeld
No abstract text is available yet for this article.
November 3, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27747812/frontal-lobe-regulation-of-blood-glucose-levels-support-for-the-limited-capacity-model-in-hostile-violence-prone-men
#13
Robert P Walters, Patti Kelly Harrison, Ransom W Campbell, David W Harrison
Hostile men have reliably displayed an exaggerated sympathetic stress response across multiple experimental settings, with cardiovascular reactivity for blood pressure and heart rate concurrent with lateralized right frontal lobe stress (Trajanoski et al., in Diabetes Care 19(12):1412-1415, 1996; see Heilman et al., in J Neurol Neurosurg Psychiatry 38(1):69-72, 1975). The current experiment examined frontal lobe regulatory control of glucose in high and low hostile men with concurrent left frontal lobe (Control Oral Word Association Test [verbal]) or right frontal lobe (Ruff Figural Fluency Test [nonverbal]) stress...
December 2016: Brain Informatics
https://www.readbyqxmd.com/read/27686364/charcot-marie-tooth-disease-type-2g-redefined-by-a-novel-mutation-in-lrsam1
#14
Kristien Peeters, Paulius Palaima, Ana L Pelayo-Negro, Antonio García, Elena Gallardo, Rosario García-Barredo, Ligia Mateiu, Jonathan Baets, Björn Menten, Els De Vriendt, Peter De Jonghe, Vincent Timmerman, Jon Infante, José Berciano, Albena Jordanova
OBJECTIVE: To identify the unknown genetic cause in a large pedigree previously classified with a distinct form of axonal Charcot-Marie-Tooth disease type 2G (CMT2G) and to explore its transcriptional consequences. METHODS: Clinical reevaluation of the pedigree was performed, followed by linkage analysis with the redefined disease statuses, and whole genome and exome sequencing. The impact of the mutation was investigated by immunoblotting and transcriptome sequencing...
December 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27662449/tdcs-effects-on-verbal-fluency-a-response-to-vannorsdall-et-al-2016
#15
Zaira Cattaneo, Alberto Pisoni, Marcello Gallucci, Costanza Papagno
In a prior study (Cattaneo et al, 2011. Neuroscience. 183:64-70), we demonstrated that anodal transcranial direct current stimulation (tDCS) over the left inferior frontal gyrus enhanced verbal fluency in healthy young adults. Although our data are in line with the results of other published studies, another research group recently failed to report anodal tDCS effects on verbal fluency using a paradigm similar to ours (Vannorsdall et al, 2016. Cogn Behav Neurol. 29:11-17). Here we discuss aspects of study design and interpretation of results that should be considered in replications, focusing particularly on homogeneity of procedures...
September 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27607069/-peripheral-nerve-injuries-in-sports
#16
B Tettenborn, S Mehnert, I Reuter
Peripheral nerve injuries due to sports are relatively rare but the exact incidence is not known due to a lack of epidemiological studies. Particular sports activities tend to cause certain peripheral nerve injuries including direct acute compression or stretching, repetitive compression and stretching over time, or another mechanism such as ischemia or laceration. These nerve lesions may be severe and delay or preclude the athlete's return to sports, especially in cases with delayed diagnosis. Repetitive and vigorous use or overuse makes the athlete vulnerable to disorders of the peripheral nerves, and sports equipment may cause compression of the nerves...
September 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27604736/closed-head-tbi-model-of-multiple-morbidity
#17
Floyd J Thompson, Jiamei Hou, Prodip K Bose
Successful therapy for TBI disabilities awaits refinement in the understanding of TBI neurobiology, quantitative measurement of treatment-induced incremental changes in recovery trajectories, and effective translation to human TBI using quantitative methods and protocols that were effective to monitor recovery in preclinical models. Details of the specific neurobiology that underlies these injuries and effective quantitation of treatment-induced changes are beginning to emerge utilizing a variety of preclinical and clinical models (for reviews see (Morales et al...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27592845/retraction-statement-dynamics-of-cytochrome-c-oxidase-activity-in-acute-ischemic-stroke-by-selakovi%C3%A4-v-m-jovanovi%C3%A4-m-d-mihajlovi%C3%A4-r-r-and-radenovi%C3%A4-l-l-j
#18
(no author information available yet)
The above article from Acta Neurologica Scandinavica, published online on 7 April 2005 in Wiley Online Library (wileyonlinelibrary.com) and in Volume 111, pp. 329-332, has been retracted by agreement between the journal Editor in Chief, Professor Elinor Ben-Menachem, and John Wiley & Sons Ltd. The article has been retracted because a similar article had previously been published in the Jugoslovenska medicinska biohemija in 2003. The authors presumed that since the journal was no longer existing, they felt the need to re-publish their work in Acta Neuorologica Scandinavica...
2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27566615/study-of-the-anti-seizure-effects-of-low-frequency-stimulation-following-kindling-a-review-of-the-cellular-mechanism-related-to-the-anti-seizure-effects-of-low-frequency-electrical-stimulation
#19
Zohreh Ghotbeddin, Mahyar Janahmadi, Ali Yadollahpour
Epilepsy affects about 1-2 % of world population as a chronic neurological disease that is manifested by repeated and consecutive seizures (Grone and Baraban, Nat Neurosci 18(3):339-343, 2015). There is no definitive therapy for epilepsy and antiepileptic drugs cannot offer a permanent and definitive cure for epilepsy, and most epileptic patients become drug resistant (Sasa, J Pharmacol Sci 100(5):487-494, 2006). Surgery and removal of the epileptic focus is a substitute method for treating drug-resistant patients and epilepsy surgery of either side of the brain improves seizure control...
August 26, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27539451/axon-topography-of-layer-6-spiny-cells-to-orientation-map-in-the-primary-visual-cortex-of-the-cat-area-18
#20
Fuyuki Karube, Katalin Sári, Zoltán F Kisvárday
To uncover the functional topography of layer 6 neurons, optical imaging was combined with three-dimensional neuronal reconstruction. Apical dendrite morphology of 23 neurons revealed three distinct types. Type Aa possessed a short apical dendrite with many oblique branches, Type Ab was characterized by a short and less branched apical dendrite, whereas Type B had a long apical dendrite with tufts in layer 2. Each type had a similar number of boutons, yet their spatial distribution differed from each other in both radial and horizontal extent...
August 18, 2016: Brain Structure & Function
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