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https://www.readbyqxmd.com/read/27871439/corrigendum-to-mortality-of-advanced-parkinson-s-disease-patients-treated-with-deep-brain-stimulation-surgery-j-neurol-sci-369-230-235
#1
Sun Ju Chung
No abstract text is available yet for this article.
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27862206/malformations-of-cortical-development
#2
REVIEW
Rahul S Desikan, A James Barkovich
Malformations of cortical development (MCDs) compose a diverse range of disorders that are common causes of neurodevelopmental delay and epilepsy. With improved imaging and genetic methodologies, the underlying molecular and pathobiological characteristics of several MCDs have been recently elucidated. In this review, we discuss genetic and molecular alterations that disrupt normal cortical development, with emphasis on recent discoveries, and provide detailed radiological features of the most common and important MCDs...
November 11, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27859541/ambroxol-effects-in-glucocerebrosidase-and-%C3%AE-synuclein-transgenic-mice
#3
Anna Migdalska-Richards, Liam Daly, Erwan Bezard, Anthony H V Schapira
OBJECTIVE: Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small molecule chaperone that has been shown to increase glucocerebrosidase activity in vitro. This study investigated the effect of ambroxol treatment on glucocerebrosidase activity and on α-synuclein and phosphorylated α-synuclein protein levels in mice...
November 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27817964/corrigendum-to-simultaneous-multisystem-surgery-an-important-capability-for-the-civilian-trauma-hospital-clin-neurol-neurosurg-148-2016-13-16
#4
Justin M Moore, Piers A W Thomas, Russell L Gruen, Patrick Chan, Jeffrey V Rosenfeld
No abstract text is available yet for this article.
November 3, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27747812/frontal-lobe-regulation-of-blood-glucose-levels-support-for-the-limited-capacity-model-in-hostile-violence-prone-men
#5
Robert P Walters, Patti Kelly Harrison, Ransom W Campbell, David W Harrison
Hostile men have reliably displayed an exaggerated sympathetic stress response across multiple experimental settings, with cardiovascular reactivity for blood pressure and heart rate concurrent with lateralized right frontal lobe stress (Trajanoski et al., in Diabetes Care 19(12):1412-1415, 1996; see Heilman et al., in J Neurol Neurosurg Psychiatry 38(1):69-72, 1975). The current experiment examined frontal lobe regulatory control of glucose in high and low hostile men with concurrent left frontal lobe (Control Oral Word Association Test [verbal]) or right frontal lobe (Ruff Figural Fluency Test [nonverbal]) stress...
December 2016: Brain Informatics
https://www.readbyqxmd.com/read/27686364/charcot-marie-tooth-disease-type-2g-redefined-by-a-novel-mutation-in-lrsam1
#6
Kristien Peeters, Paulius Palaima, Ana L Pelayo-Negro, Antonio García, Elena Gallardo, Rosario García-Barredo, Ligia Mateiu, Jonathan Baets, Björn Menten, Els De Vriendt, Peter De Jonghe, Vincent Timmerman, Jon Infante, José Berciano, Albena Jordanova
OBJECTIVE: To identify the unknown genetic cause in a large pedigree previously classified with a distinct form of axonal Charcot-Marie-Tooth disease type 2G (CMT2G) and to explore its transcriptional consequences. METHODS: Clinical reevaluation of the pedigree was performed, followed by linkage analysis with the redefined disease statuses, and whole genome and exome sequencing. The impact of the mutation was investigated by immunoblotting and transcriptome sequencing...
September 30, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27662449/tdcs-effects-on-verbal-fluency-a-response-to-vannorsdall-et-al-2016
#7
Zaira Cattaneo, Alberto Pisoni, Marcello Gallucci, Costanza Papagno
In a prior study (Cattaneo et al, 2011. Neuroscience. 183:64-70), we demonstrated that anodal transcranial direct current stimulation (tDCS) over the left inferior frontal gyrus enhanced verbal fluency in healthy young adults. Although our data are in line with the results of other published studies, another research group recently failed to report anodal tDCS effects on verbal fluency using a paradigm similar to ours (Vannorsdall et al, 2016. Cogn Behav Neurol. 29:11-17). Here we discuss aspects of study design and interpretation of results that should be considered in replications, focusing particularly on homogeneity of procedures...
September 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27607069/-peripheral-nerve-injuries-in-sports
#8
B Tettenborn, S Mehnert, I Reuter
Peripheral nerve injuries due to sports are relatively rare but the exact incidence is not known due to a lack of epidemiological studies. Particular sports activities tend to cause certain peripheral nerve injuries including direct acute compression or stretching, repetitive compression and stretching over time, or another mechanism such as ischemia or laceration. These nerve lesions may be severe and delay or preclude the athlete's return to sports, especially in cases with delayed diagnosis. Repetitive and vigorous use or overuse makes the athlete vulnerable to disorders of the peripheral nerves, and sports equipment may cause compression of the nerves...
September 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27604736/closed-head-tbi-model-of-multiple-morbidity
#9
Floyd J Thompson, Jiamei Hou, Prodip K Bose
Successful therapy for TBI disabilities awaits refinement in the understanding of TBI neurobiology, quantitative measurement of treatment-induced incremental changes in recovery trajectories, and effective translation to human TBI using quantitative methods and protocols that were effective to monitor recovery in preclinical models. Details of the specific neurobiology that underlies these injuries and effective quantitation of treatment-induced changes are beginning to emerge utilizing a variety of preclinical and clinical models (for reviews see (Morales et al...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27592845/retraction-statement-dynamics-of-cytochrome-c-oxidase-activity-in-acute-ischemic-stroke-by-selakovi%C3%A4-v-m-jovanovi%C3%A4-m-d-mihajlovi%C3%A4-r-r-and-radenovi%C3%A4-l-l-j
#10
(no author information available yet)
The above article from Acta Neurologica Scandinavica, published online on 7 April 2005 in Wiley Online Library (wileyonlinelibrary.com) and in Volume 111, pp. 329-332, has been retracted by agreement between the journal Editor in Chief, Professor Elinor Ben-Menachem, and John Wiley & Sons Ltd. The article has been retracted because a similar article had previously been published in the Jugoslovenska medicinska biohemija in 2003. The authors presumed that since the journal was no longer existing, they felt the need to re-publish their work in Acta Neuorologica Scandinavica...
October 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27566615/study-of-the-anti-seizure-effects-of-low-frequency-stimulation-following-kindling-a-review-of-the-cellular-mechanism-related-to-the-anti-seizure-effects-of-low-frequency-electrical-stimulation
#11
Zohreh Ghotbeddin, Mahyar Janahmadi, Ali Yadollahpour
Epilepsy affects about 1-2 % of world population as a chronic neurological disease that is manifested by repeated and consecutive seizures (Grone and Baraban, Nat Neurosci 18(3):339-343, 2015). There is no definitive therapy for epilepsy and antiepileptic drugs cannot offer a permanent and definitive cure for epilepsy, and most epileptic patients become drug resistant (Sasa, J Pharmacol Sci 100(5):487-494, 2006). Surgery and removal of the epileptic focus is a substitute method for treating drug-resistant patients and epilepsy surgery of either side of the brain improves seizure control...
August 26, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27539451/axon-topography-of-layer-6-spiny-cells-to-orientation-map-in-the-primary-visual-cortex-of-the-cat-area-18
#12
Fuyuki Karube, Katalin Sári, Zoltán F Kisvárday
To uncover the functional topography of layer 6 neurons, optical imaging was combined with three-dimensional neuronal reconstruction. Apical dendrite morphology of 23 neurons revealed three distinct types. Type Aa possessed a short apical dendrite with many oblique branches, Type Ab was characterized by a short and less branched apical dendrite, whereas Type B had a long apical dendrite with tufts in layer 2. Each type had a similar number of boutons, yet their spatial distribution differed from each other in both radial and horizontal extent...
August 18, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27539385/gene-expression-analysis-of-developing-cell-groups-in-the-pretectal-region-of-xenopus-laevis
#13
Ruth Morona, José Luis Eduardo Ferran, Luis Puelles, Agustín González
Our previous analysis of progenitor domains in the pretectum of Xenopus revealed three molecularly distinct anteroposterior subdivisions identified as precommissural (PcP), juxtacommissural (JcP), and commissural (CoP) histogenetic domains (Morona et al. [2011] J Comp Neurol 519:1024-1050). Here we analyzed at later developmental stages the nuclei derived from these areas, attending to their gene expression patterns and histogenesis. Transcription-factor gene markers were used to selectively map derivatives of each domain: Pax7 and Pax6 (CoP); Foxp1 and Six3 (JcP); and Xiro1, VGlut2, Ebf1, and Ebf3 (PcP)...
August 19, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27503489/computation-of-a-high-resolution-mri-3d-stereotaxic-atlas-of-the-sheep-brain
#14
Arsène Ella, José A Delgadillo, Philippe Chemineau, Matthieu Keller
The sheep model was first used in the fields of animal reproduction and veterinary sciences and then was utilized in fundamental and preclinical studies. For more than a decade, magnetic resonance (MR) studies performed on this model have been increasingly reported, especially in the field of neuroscience. To contribute to MR translational neuroscience research, a brain template and an atlas are necessary. We have recently generated the first complete T1-weighted (T1W) and T2W MR population average images (or templates) of in vivo sheep brains...
August 9, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27457368/drug-interaction-and-serotonin-toxicity-with-opioid-use-another-reason-to-avoid-opioids-in-headache-and-migraine-treatment
#15
REVIEW
Hossein Ansari, Leila Kouti
Treatment of headache, specifically migraine attacks, has always been a challenging subject, especially for neurologist and pain specialists. Triptans are generally underutilized, despite being the gold standard abortive medication for migraine attacks. On the other hand, opioid analgesics are overused as a treatment for headache. One reason for this could be physician unfamiliarity with drug interactions between opioids and other medications, especially the possibility of serotonin toxicity. The general awareness of potential serotonin toxicity with using opioid analgesics is low...
August 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/27375153/corrigendum-to-evolution-of-diagnostic-criteria-for-multiple-sclerosis-pol-j-neurol-neurosurg-49-5-2015-313-321
#16
Joanna Przybek, Inga Gniatkowska, Dagmara Mirowska-Guzel, Anna Członkowska
No abstract text is available yet for this article.
July 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27351833/clinically-distinct-electroencephalographic-phenotypes-of-early-myoclonus-after-cardiac-arrest
#17
Jonathan Elmer, Jon C Rittenberger, John Faro, Bradley J Molyneaux, Alexandra Popescu, Clifton W Callaway, Maria Baldwin
OBJECTIVE: We tested the hypothesis that there are readily classifiable electroencephalographic (EEG) phenotypes of early postanoxic multifocal myoclonus (PAMM) that develop after cardiac arrest. METHODS: We studied a cohort of consecutive comatose patients treated after cardiac arrest from January 2012 to February 2015. For patients with clinically evident myoclonus before awakening, 2 expert physicians reviewed and classified all EEG recordings. Major categories included: Pattern 1, suppression-burst background with high-amplitude polyspikes in lockstep with myoclonic jerks; and Pattern 2, continuous background with narrow, vertex spike-wave discharges in lockstep with myoclonic jerks...
August 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27277836/normalization-of-network-connectivity-in-hemispatial-neglect-recovery
#18
Lenny E Ramsey, Joshua S Siegel, Antonello Baldassarre, Nicholas V Metcalf, Kristina Zinn, Gordon L Shulman, Maurizio Corbetta
OBJECTIVE: We recently reported that spatial and nonspatial attention deficits in stroke patients with hemispatial neglect are correlated at 2 weeks postonset with widespread alterations of interhemispheric and intrahemispheric functional connectivity (FC) measured with resting-state functional magnetic resonance imaging across multiple brain networks. The mechanisms underlying neglect recovery are largely unknown. In this study, we test the hypothesis that recovery of hemispatial neglect correlates with a return of network connectivity toward a normal pattern, herein defined as "network normalization...
July 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27265096/erratum-to-charcot-marie-tooth-type-2-and-distal-hereditary-motor-neuropathy-clinical-neurophysiological-and-genetic-findings-from-a-single-centre-experience-clin-neurol-neurosurg-144-2016-67-71
#19
Marco Luigetti, Gian Maria Fabrizi, Giulia Bisogni, Angela Romano, Federica Taioli, Moreno Ferrarini, Daniela Bernardo, Paolo Maria Rossini, Mario Sabatelli
No abstract text is available yet for this article.
June 2, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27255958/the-amyloid-cascade-hypothesis-are-we-poised-for-success-or-failure
#20
Eric Karran, Bart De Strooper
The first description of Alzheimer's disease (AD) was made in 1907 by Alois Alzheimer (Allgemeine Zeitschrift fur Psyciatrie und Psychisch-Gerichtliche Medizin 64, 3, 1907), although other contemporary physicians had made similar, and rather more complete, assessments of the neuropathological changes present in the AD brain (Fischer, Monatsschr Psychiat Neurol 22, 17, 1907). Our knowledge of AD has increased dramatically and continues to accelerate. This year is 25 years after the publication of a series of papers that, in various ways, articulated the amyloid cascade hypothesis (ACH) for AD (Beyreuther and Masters, Brain Pathol 1, 241-251, 1991; Hardy and Allsop, Trends Pharmacol Sci 12, 383-388, 1991; Selkoe, Neuron 6, 487-498, 1991; Hardy and Higgins, Science 256, 184-185, 1992)...
June 3, 2016: Journal of Neurochemistry
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