Hilal Üstündağ, Adem Kara, Songül Doğanay, Nezahat Kurt, Elif Erbaş, Ferdane Danişman Kalindemirtaş, İshak Afşin Kariper
Sepsis is a life-threatening condition characterized by a systemic inflammatory response to infection. Despite extensive research on its pathophysiology, effective therapeutic approaches remain a challenge. This study investigated the potential of resveratrol (RV) and silver nanoparticle-enhanced resveratrol (AgNP-RV) as treatments for sepsis-induced lung injury using a rat model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). The study focused on evaluating changes in oxidative status (TAS, TOS, and OSI) and the expression of inflammatory and apoptotic markers (IL-1β, TNF-α, P2X7R, TLR4, Caspase-3, and Bcl-2) in lung tissue...
March 28, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology