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https://www.readbyqxmd.com/read/29025172/-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-paediatric-patients-with-optic-neuritis
#1
Helmut Tegetmeyer, Andreas Merkenschlager
Background Myelin oligodendrocyte glycoprotein (MOG) is located on the surface of oligodendrocytes and myelin in the central nervous system. MOG-IgG is associated with acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis (NNO), and transverse myelitis (TM) in both paediatric and adult patients. The combination of NNO and TM or other inflammatory brain lesions is a typical feature of neuromyelitis optica spectrum disorders (NMO-SD) which are associated with specific pathogenic autoantibodies against the water channel aquaporin-4 (AQP4-IgG)...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29022114/implantable-systems-for-stress-urinary-incontinence
#2
REVIEW
Kenana M Al Adem, Sarah S Bawazir, Waleed A Hassen, Ahsan H Khandoker, Kinda Khalaf, Tim McGloughlin, Cesare Stefanini
Stress urinary incontinence (SUI), the involuntary urine leakage due to failure of the urethral closure mechanism, is a global health challenge with substantial human suffering and socioeconomic costs. Approximately 167 million male and female patients are predicted to suffer from SUI in 2018, worldwide. A wide range of surgical interventions are available for the treatment of SUI. Severe cases, however, usually require the implantation of artificial urinary sphincter devices. This review comparatively presents and analyzes the working principles, as well as the challenges, associated with the current implantable SUI systems in clinical use...
October 11, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29016369/newly-developed-left-ventricular-apical-thrombus-under-dabigatran-treatment
#3
Adem Adar, Orhan Onalan, Fahri Cakan
: Left ventricular (LV) thrombi are mostly formed in the aneurysmal or akinetic segment of the LV apex. Thromboembolism to the brain is usually fatal. There is not enough information available regarding the use of these new oral anticoagulant agents in LV thrombi. In this case, we present a 56-year-old male patient who was given dabigatran (150 mg, twice a day) for paroxysmal atrial fibrillation after experiencing anterior myocardial infarction. During the use of dabigatran, thrombus formation, which was not present earlier, was observed in the LV apical aneurysm...
October 7, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28994333/pyruvate-kinase-activators-as-a-therapy-target-a-patent-review-2011-2017
#4
Sevki Adem, Veysel Comakli, Naim Uzun
It is well known that cancer cells have an altered metabolism both to meet the energy needs and to provide initial molecules for the synthesis of macromolecules. To cope with the new metabolic state, different forms of certain enzymes are expressed in extreme amounts. These enzymes are seen as very attractive targets to deal with cancer. Pyruvate kinases isoenzyme M2 (PKM2) is a key enzyme that determines whether glucose is used for energy or synthesis of biosynthetic molecules. The dimeric form of PKM2 main form in several cancer cells serves the formation of synthetic precursors required for the cell growth and proliferation from glycolytic intermediates...
October 10, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28990941/influence-of-coronary-calcification-patterns-on-hemodynamic-outcome-of-coronary-stenoses-and-remodeling
#5
Ahmet Demirkıran, Ozan Çakır, Adem Atıcı, Emre Aslanger, Cansu Akdeniz, Berrin Umman, Sabahattin Umman, Zehra Bugra, Murat Sezer
OBJECTIVE: The histological characteristics of plaque may affect the hemodynamic outcome of a given coronary stenosis. In particular, the potential effect of volumetric calcium content and the topographical distribution in the lesion segment on physiological outcome has not yet been investigated. The aim of this study was to identify any potential correlation between patterns of calcification and the fractional flow reserve (FFR) and the coronary remodeling index (RMI). METHODS: A total of 26 stable angina pectoris and 34 acute coronary syndrome patients without persistent ST-segment elevation constituted the study population...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28990890/effect-of-reduction-mammoplasty-on-the-pulmonary-function-tests
#6
Erhan Uğurlu, Adem Topkara, Adem Özkan, Ramazan Hakan Özcan, İlknur Can, Göksel Altınışık
Introduction: Bilateral breast reduction surgery is the surgical treatment of bilateral breast hypertrophy. This is one of the most common breast surgery requested by women, and performed by plastic surgeons. The reasons that patients want this surgery are to re-size sagging breasts aesthetically, and to get rid of somatic symptoms such as shoulder, chest, back, and neck pain. We believe that the objective positive effects of breast reduction surgery exist beside aesthetic. In our study, our aim is to elicit positive effects of surgery on lungs, if there are, by making pulmonary function test and carbon monoxide diffusion test before surgery and after 6 months of surgery...
June 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28988756/synthesis-and-in-vitro-biological-evaluation-of-new-pyrimidines-as-glucagon-like-peptide-1-receptor-agonists
#7
Shaikha S AlNeyadi, Abdu Adem, Naheed Amer, Alaa A Salem, Ibrahim M Abdou
The therapeutic success of peptide glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of type 2 diabetes mellitus has inspired discovery efforts aimed at developing orally available small-molecule GLP-1 receptor agonists. In this study, two series of new pyrimidine derivatives were designed and synthesized using an efficient route, and were evaluated in terms of GLP-1 receptor agonist activity. In the first series, novel pyrimidines substituted at positions 2 and 4 with groups varying in size and electronic properties were synthesized in a good yield (78-90%)...
September 14, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28983397/measles-outbreak-investigation-in-guji-zone-of-oromia-region-ethiopia
#8
Ketema Belda, Ayesheshem Ademe Tegegne, Amare Mengistu Mersha, Mekonnen Getahun Bayenessagne, Ibrahim Hussein, Belay Bezabeh
INTRODUCTION: Despite the increase of immunization coverage (administrative) of measles in the country, there are widespread outbreaks of measles. In this respect, we investigated one of the outbreaks that occurred in hard to reach kebeles of Guji Zone, Oromia region, to identify the contributing factors that lead to the protracted outbreak of measles. METHODS: We used a cross-sectional study design to investigate a measles outbreak in Guji zone, Oromia region. Data entry and analysis was performed using EPI-Info version 7...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28983396/assessment-of-reporting-sites-for-acute-flaccid-paralysis-surveillance-in-ethiopia-implications-for-planning-of-active-case-search-visits
#9
Eshetu Wassie, Ayesheshem Ademe, Kathleen Gallagher, Fiona Braka, Berhane Beyene, Abyot Bekele Woyessa, Daddi Jima
INTRODUCTION: The World Health Organization acute flaccid paralysis (AFP) surveillance standards recommend documentation of the role of each potentially reporting site for evidence -based planning and tailoring support for active surveillance visits. This study assessed the contribution of various sites as source and quality of AFP cases reported over a five -year period in Ethiopia. METHODS: We conducted a retrospective analysis of AFP surveillance data collected from 2010-2014 in Ethiopia...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28983395/assessment-of-source-of-information-for-polio-supplementary-immunization-activities-in-2014-and-2015-somali-ethiopia
#10
Selamawit Yilma Bedada, Kathleen Gallagher, Aron Kassahun Aregay, Bashir Mohammed, Mohammed Adem Maalin, Hassen Abdisemed Hassen, Yusuf Mohammed Ali, Fiona Braka, Pierre M'pele Kilebou
INTRODUCTION: Communication is key for the successful implementation of polio vaccination campaigns. The purpose of this study is to review and analyse the sources of information utilized by caregivers during polio supplementary immunization activities (SIAs) in Somali, Ethiopia in 2014 and 2015. METHODS: Data on sources of information about the polio campaign were collected post campaign from caregivers by trained data collectors as part of house to house independent monitoring...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28983394/status-of-surveillance-and-routine-immunization-performances-in-amhara-region-ethiopia-findings-from-in-depth-peer-review
#11
Gebre Asmamaw Lakew, Eshetu Wassie, Ayesheshem Ademe, Ayalneh Fenta, Solomon Wube, Mihret Werede, Achenef Kidane, Leulseged Mekonnen, Teklehaimanot Gebre Hiwot, Kathleen Gallagher
INTRODUCTION: Trend analyses of non-polio AFP and stool adequacy rates in Amhara Region showed optimal performance over the years. However, sub regional gaps continue to persist in certain zones where the reasons for low performance were not well documented. The objective of this study was to assess the performance of the disease surveillance and immunization system in Amhara Region, Ethiopia with emphasis on low performing woredas and zones. METHODS: A descriptive cross-sectional study was conducted from July 2-10, 2015 to assess the structure, core and support surveillance functions in five zones and two town administrations that were purposively sampled based on differing performances, geographic location, and history of vaccine preventable disease outbreaks among others...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28983391/health-care-seeking-behavior-of-parents-with-acute-flaccid-paralysis-child
#12
Ayesheshem Ademe Tegegne, Amare Mengistu Mersha
INTRODUCTION: Despite the tremendous increase in the number of modern health institutions, traditional medical practices still remain alternative places of health care service delivery and important sites for disease notification in the disease surveillance system. The objectives of this study are to describe the patterns and factors associated with health care seeking behavior of parents and care takers with acute flaccid paralysis child and see how the traditional practice affect the surveillance system...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28980281/evaluating-the-effects-of-cardiac-resynchronization-therapy-on-pathophysiological-pathways-of-heart-failure-using-surrogate-biomarkers
#13
Hamza Sunman, Adem Özkan, Hikmet Yorgun, Uğur Canpolat, Erdem Karabulut, Tülin Bayrak, Ergün Barış Kaya, Lale Tokgözoğlu, Necla Özer, Asuman Özkara, Kudret Aytemir, Ali Oto
BACKGROUND: Several studies have investigated the effects of cardiac resynchronization therapy (CRT) on heart failure (HF), but none have evaluated the pathophysiological pathways involved in a single group of patients. Therefore, this study aims to assess the long-term effects of CRT on six different pathophysiological pathways involved in the process of HF by the use of surrogate biomarkers. METHODS: In a group 44 patients with HF, six groups of biomarkers were measured, both at baseline and 1 year after CRT implantation: Inflammation (interleukin [IL]-4, IL-6, tumor necrosis factor [TNF]-α, high sensitive C-reactive protein [hsCRP]); oxidative stress (myeloperoxidase, oxidized low-density lipoprotein [oxLDL], uric acid); extracellular matrix (ECM) remodeling (matrix metalloproteinase [MMP]-2 and -9, galectin-3, procollagen III N-terminal propeptide [prokol-3NT]); neurohormonal pathways (endothelin-1, chromogranin-A); myocyte injury (troponin T, creatine kinase MB fraction [CK-MB]), myocyte stress (B-type natriuretic peptide [BNP])...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28977051/non-sustained-ventricular-tachycardia-episodes-predict-future-hospitalization-in-icd-recipients-with-heart-failure
#14
Fatih Mehmet Uçar, Mustafa Adem Yilmaztepe, Gökay Taylan, Meryem Aktoz
BACKGROUND: Implantable cardioverter-defibrillator (ICD) therapy is well known to reduce mortality in selected patients with heart failure (HF). OBJECTIVE: To investigate whether monitored episodes of non-sustained ventricular tachycardia (NSVT) might predict future HF hospitalizations in ICD recipients with HF. METHODS: We examined 104 ICD recipients (mean age: 60 ± 10.1 years, 80.8 % male) with HF who were referred to our outpatient clinic for device follow-up...
October 2, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28936092/multifocal-balo-s-concentric-sclerosis-in-children-report-of-a-case-and-review-of-literature
#15
Sanjeev Kumar Bhoi, Suprava Naik, Jayantee Kalita, U K Misra
Balo's concentric sclerosis (BCS) is a rare demyelinating lesion considered to be a variant of multiple sclerosis (MS). On magnetic resonance imaging (MRI) Balo's concentric sclerosis shows the typical concentric pattern. We report a case of 10 year old child with BCS who presented as post infectious acute disseminated encephalomyelitis (ADEM). He is asymptomatic and had no relapse after 6 years of follow-up.
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28919093/clip-closure-and-division-instead-of-stapling-for-the-last-small-gastric-bridge-between-gastric-pouch-and-remnant-stomach-in-laparoscopic-roux-en-y-gastric-bypass
#16
Adem Yuksel, Fatih Sumer, Cuneyt Kayaalp
INTRODUCTION: Here, a modification during gastric pouch forming was implemented in laparoscopic Roux-en-Y gastric bypass (LRYGB). We aimed to examine the feasibility of metallic clip closure for the remaining small stomach bridges (<1 cm) between the pouch and the remnant stomach. METHODS: During pouch creation, after the last stapler firing, the remaining small bridge was closed with clips and divided instead of using a new stapler. Metallic clips for this aim were used in 41 of 520 LRYGP between September 2010 and January 2017...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28911638/assessment-of-antibacterial-drug-residues-in-milk-for-consumption-in-kosovo
#17
Adem Rama, Lorena Lucatello, Cristiana Benetti, Guglielmo Galina, Drita Bajraktari
The objective of this study was to assess the occurrence of drug residues in the raw milk collected from individual farms and milk collection points during 2009-2010 in six different major regions of Kosovo (Prishtinë, Gjilan, Mitrovicë, Pejë, Gjakovë, Prizren). In the present study, a total of 1734 raw milk samples were collected, and qualitatively screened with two different tests, the Delvotest SP assay and an enzyme-linked receptor-binding assay (SNAP). Overall, 106 (6.11%) out of 1734 samples examined with Delvotest SP contained possible drug residues (5...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904691/il-21-augments-rapamycin-in-expansion-of-alpha-fetoprotein-antigen-specific-stem-cell-like-memory-t-cells-in-vitro
#18
Victor Tunje Jeza, Xiaoyi Li, Jun Chen, Zhihui Liang, Adem Onago Aggrey, Xiongwen Wu
INTRODUCTION: Alloreactive tumor specific T cells are important arsenals of the adaptive immune system in the fight against tumors. However, stem cell-like memory T cells (Tscm) provide the key to effective elimination of tumor cells. Methods for generating these T cell subsets already exist. However, they could be made more efficient. Further, they are expensive and unattainable to the resource poor laboratories. In this regard, we are hereby describing a novel in vitro allogeneic co-culture method for raising allo-restricted tumor specific Tscm cells that we developed...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904469/hyper-acute-demyelinating-encephalomyelitis-of-childhood-a-rare-entity
#19
Suman Kushwaha, Ashutosh Gupta, Neha Agarwal, Sujata Chaturvedi, Deepak Jha
A young child with catastrophic neurological illness diagnosed as a rare variant of acute demyelinating encephalomyelitis (ADEM). She succumbed to her illness despite of aggressive and appropriate management. Malignant demyelinating encephalomyelitis should be considered in children who are refractory to the treatment of ADEM.
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28904373/spatial-and-temporal-distribution-of-phase-slips-in-josephson-junction-chains
#20
Adem Ergül, Thomas Weißl, Jan Johansson, Jack Lidmar, David B Haviland
The Josephson effect, tunnelling of a supercurrent through a thin insulator layer between two superconducting islands, is a phenomena characterized by a spatially distributed phase of the superconducting condensate. In recent years, there has been a growing focus on Josephson junction devices particularly for the applications of quantum metrology and superconducting qubits. In this study, we report the development of Josephson junction circuit formed by serially connecting many Superconducting Quantum Interference Devices, SQUIDs...
September 13, 2017: Scientific Reports
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