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https://www.readbyqxmd.com/read/28533781/myelin-oligodendrocyte-glycoprotein-deciphering-a-target-in-inflammatory-demyelinating-diseases
#1
REVIEW
Patrick Peschl, Monika Bradl, Romana Höftberger, Thomas Berger, Markus Reindl
Myelin oligodendrocyte glycoprotein (MOG), a member of the immunoglobulin (Ig) superfamily, is a myelin protein solely expressed at the outermost surface of myelin sheaths and oligodendrocyte membranes. This makes MOG a potential target of cellular and humoral immune responses in inflammatory demyelinating diseases. Due to its late postnatal developmental expression, MOG is an important marker for oligodendrocyte maturation. Discovered about 30 years ago, it is one of the best-studied autoantigens for experimental autoimmune models for multiple sclerosis (MS)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28528241/peripheral-zinc-and-neopterin-concentrations-are-associated-with-mood-severity-in-bipolar-disorder-in-a-gender-specific-manner
#2
Caitlin E Millett, Dahlia Mukherjee, Aubrey Reider, Adem Can, Maureen Groer, Dietmar Fuchs, Teodor T Postolache, Shannon L Kelleher, Erika F H Saunders
Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28503983/design-and-in-vitro-evaluation-of-tenofovir-loaded-vaginal-gels-for-the-prevention-of-hiv-infections
#3
Selin Seda Timur, Adem Şahin, Eren Aytekin, Naile Öztürk, Kerem Heybet Polat, Nurten Tezel, Reyhan Neslihan Gürsoy, Sema Çalış
Infection with the human immunodeficiency virus (HIV) is affecting women disproportionally with increasing incidence rates over the last decades. Tenofovir is one of the most commonly used antiretroviral agents, which belongs to the nucleoside/nucleotide reverse transcriptase inhibitor family, for the prevention of HIV acquisition. In scope of this study, a thermogelling system containing tenofovir - loaded chitosan nanoparticles for the controlled release of tenofovir was developed and characterized. The in vitro release studies have shown that the burst release effect was decreased to 27% with f-TFV CS NPs-Gel...
May 15, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28490165/remote-cerebellar-hemorrhage-presenting-with-cerebellar-mutism-after-spinal-surgery-an-unusual-case-report
#4
Halil Murat Sen, Mustafa Guven, Adem Bozkurt Aras, Murat Cosar
Dural injury during spinal surgery can subsequently give rise to a remote cerebellar hemorrhage (RCH). Although the incidence of such injury is low, the resulting hemorrhage can be life threatening. The mechanism underlying the formation of the hemorrhage is not known, but it is mostly thought to develop after venous infarction. Cerebellar mutism (CM) is a frequent complication of posterior fossa operations in children, but it is rarely seen in adults. The development of CM after an RCH has not been described...
May 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28488621/tumefactive-acute-disseminated-encephalomyelitis
#5
Sunil Pradhan, Surjyaprakash S Choudhury, Animesh Das
Tumefactive demyelinating lesions are tumour-like presentations of acute demyelinating lesions. They have been described with multiple sclerosis only and not with other varieties of acquired demyelination like acute disseminated encephalomyelitis (ADEM). The uncertainty about the diagnosis at the onset of the disease in tumefactive ADEM makes it important that the physicians should be aware of this entity. Various radiological similarities with more sinister lesions like central nervous system gliomas or lymphomas may lead to this confusion...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28487041/comparison-of-pharyngocutaneous-fistula-closure-with-and-without-bacterial-cellulose-in-a-rat-model
#6
Berat Demir, Murat Sarı, Adem Binnetoglu, Ali Cemal Yumusakhuylu, Deniz Filinte, İshak Özel Tekin, Tekin Bağlam, Abdullah Çağlar Batman
OBJECTIVE: The present study aimed to compare the effects of bacterial cellulose used for closure of pharyngocutaneous fistulae, a complication of total laryngectomy, with those of primary sutures in a rat model. METHODS: Thirty female Sprague-Dawley underwent experimental pharyngoesophagotomy and were grouped depending on the material used for pharyngocutaneous fistula closure: group I, which received primary sutures alone, group II, which received bacterial cellulose alone; and group III, which received both...
May 6, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28484307/understanding-acoustic-cavitation-initiation-by-porous-nanoparticles-toward-nanoscale-agents-for-ultrasound-imaging-and-therapy
#7
Adem Yildirim, Rajarshi Chattaraj, Nicholas T Blum, Andrew P Goodwin
Ultrasound is widely applied in medical diagnosis and therapy due to its safety, high penetration depth, and low cost. In order to improve the contrast of sonographs and efficiency of the ultrasound therapy, echogenic gas bodies or droplets (with diameters from 200 nm to 10 µm) are often used, which are not very stable in the bloodstream and unable to penetrate into target tissues. Recently, it was demonstrated that nanobubbles stabilized by nanoparticles can nucleate ultrasound responsive microbubbles under reduced acoustic pressures, which is very promising for the development of nanoscale (<100 nm) ultrasound agents...
August 23, 2016: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/28480130/depolymerizable-poly-o-vinyl-carbamate-alt-sulfones-as-customizable-macromolecular-scaffolds-for-mucosal-drug-delivery
#8
Kaushlendra Kumar, Eduard Jimenez Castaño, Andrew R Weidner, Adem Yildirim, Andrew P Goodwin
Interest in stimulus responsive materials and polymers has grown over the years, having shown great promise in a diverse set of applications. For drug delivery, stimulus-responsive polymers have been shown to encapsulate therapeutic cargo such as small molecule drugs or proteins, deliver them to specific locations in the body, and release them so that they can induce a therapeutic effect in the patient. Most hydrolytically degradable polymers are synthesized via nucleophilic, anionic, or cationic polymerization, which generally requires protection of nucleophilic or protic side chains prior to polymerization...
May 17, 2016: ACS Macro Letters
https://www.readbyqxmd.com/read/28471617/causality-assessment-of-serious-neurologic-adverse-events-following-bopv-national-vaccination-campaign-in-israel
#9
Diana Tasher, Eran Kopel, Emilia Anis, Zachi Grossman, Eli Somekh
BACKGROUND: During 2013-2014 Israel experienced a continuous circulation of wild poliovirus type 1 (WPV1) but with no clinical cases. WPV1 circulation was gradually terminated following a national vaccination campaign of bivalent oral poliovirus vaccine (bOPV) for 943,587 children < 10 years. Four cases of children with neurological manifestations that appeared following bOPV vaccinations were reported during the campaign: three of Guillain-Barré syndrome (GBS) and one of acute disseminated encephalomyelitis (ADEM)...
October 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28470359/is-endoscopic-endonasal-transsphenoidal-surgery-increases-the-susceptibility-to-rhinosinusitis
#10
Muhammet Fatih Topuz, Murat Sarı, Adem Binnetoglu, Ramazan Dogrul, Onur Bugdaycı, Aşkın Şeker
The aim of the study was to analyze whether the measurement of changes in the anatomical position and volume of middle concha, the volume changes in the area between the middle concha and lamina papyracea, the evaluation of opacification in major paranasal sinuses, and osteomeatal complex occlusion in cases with middle concha by out-fracture technique during endoscopic endonasal transsphenoidal approach is a minimally invasive surgery, and also to find out whether these changes lead to the development of tendency to rhinosinusitis...
May 3, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28469990/isolated-palatal-weakness-without-optic-neuritis-as-the-presenting-manifestation-of-multiple-sclerosis-and-its-diagnostic-dilemma-with-acute-disseminated-encephalomyelitis-in-a-young-boy
#11
Virti D Shah, Sumeet Prakash Mirgh, Nirmal Surya
We present a case of a young boy who at initial presentation was diagnosed as acute disseminated encephalomyelitis (ADEM) but subsequently on follow-up was diagnosed as multiple sclerosis (MS). Differentiating ADEM from MS in their first presentation can be tricky as the features may not be typical of anyone. The importance lies in the close follow-up of these patients.
April 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28469068/crystal-structure-and-photoluminescence-properties-of-a-new-monomeric-copper-ii-complex-bis-3-3-hydroxypropyl-imino-methyl-4-nitrophenolato-%C3%AE%C2%BA-3-o-n-o-copper-ii
#12
Cagdas Kocak, Gorkem Oylumluoglu, Adem Donmez, M Burak Coban, Ugur Erkarslan, Muhittin Aygun, Hulya Kara
Copper(II)-Schiff base complexes have attracted extensive interest due to their structural, electronic, magnetic and luminescence properties. The title novel monomeric Cu(II) complex, [Cu(C10H11N2O4)2], has been synthesized by the reaction of 3-{[(3-hydroxypropyl)imino]methyl}-4-nitrophenol (H2L) and copper(II) acetate monohydrate in methanol, and was characterized by elemental analysis, UV and IR spectroscopies, single-crystal X-ray diffraction analysis and a photoluminescence study. The Cu(II) atom is located on a centre of inversion and is coordinated by two imine N atoms, two phenoxy O atoms in a mutual trans disposition and two hydroxy O atoms in axial positions, forming an elongated octahedral geometry...
May 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28467724/a-novel-decision-aid-to-support-informed-decision-making-process-in-patients-with-a-symptomatic-non-lower-pole-renal-stone-20-mm-in-diameter
#13
Mehmet Ilker Gökce, Barış Esen, Adem Sancı, Çağrı Akpınar, Evren Süer, Ömer Gülpınar
Introduction Stone disease is an important health problem and patients have different treatment choices. Shared decision making is recommended for deciding the treatment type but patient education is necessary. Decision aids (DAs) are used for this aim and herein we developed a novel DA for patients with symptomatic non-lower pole renal stones <20 mm in diameter. Materials and methods The DA development process was established based on the recommended guides. General characteristics of the stone disease and details of the shock wave lithotripsy and retrograde intrarenal surgery were included in the content of the DA...
May 3, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28465075/carbon-nanotube-capsules-enhance-the-in-vivo-efficacy-of-cisplatin
#14
Adem Guven, Gabriel J Villares, Susan G Hilsenbeck, Alaina Lewis, John D Landua, Lacey E Dobrolecki, Lon J Wilson, Michael T Lewis
Over the past few years, numerous nanotechnology-based drug delivery systems have been developed in an effort to maximize therapeutic effectiveness of conventional drug delivery, while limiting undesirable side effects. Among these, carbon nanotubes (CNTs) are of special interest as potential drug delivery agents due to their numerous unique and advantageous physical and chemical properties. Here, we show in vivo favorable biodistribution and enhanced therapeutic efficacy of cisplatin (CDDP) encapsulated within ultra-short single-walled carbon nanotube capsules (CDDP@US-tubes) using three different human breast cancer xenograft models...
April 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28461111/validated-age-specific-reference-values-for-csf-total-protein-levels-in-children
#15
V Kahlmann, J Roodbol, N van Leeuwen, C R B Ramakers, D van Pelt, R F Neuteboom, C E Catsman-Berrevoets, M C Y de Wit, B C Jacobs
OBJECTIVE: To define age-specific reference values for cerebrospinal fluid (CSF) total protein levels for children and validate these values in children with Guillain-Barré syndrome (GBS), acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS). METHODS: Reference values for CSF total protein levels were determined in an extensive cohort of diagnostic samples from children (<18 year) evaluated at Erasmus Medical Center/Sophia Children's Hospital...
April 8, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28460915/properties-of-lysozyme-sodium-alginate-complexes-for-the-development-of-antimicrobial-films
#16
Chedia Ben Amara, Noushin Eghbal, Nadia Oulahal, Pascal Degraeve, Adem Gharsallaoui
Complexation study of lysozyme (0.714g/L) by sodium alginate at pH7 showed that aggregates formation was a two-phase process. The first phase (from 0 to 0.1g/L sodium alginate) corresponded to the combination of individual complexes to form aggregates which caused an increase of turbidity and average size and a rapid sedimentation. Charge neutralization estimated by ζ-potential measurements occurred at 0.1g/L sodium alginate concentration. The second phase (from 0.1 to 4g/L of sodium alginate) was characterized by the formation of aggregates having a less dense structure with higher average size despite the drop in turbidity and the high dispersion in the medium...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28450468/barriers-to-evidence-based-acute-stroke-care-in-ghana-a-qualitative-study-on-the-perspectives-of-stroke-care-professionals
#17
Leonard Baatiema, Ama de-Graft Aikins, Adem Sav, George Mnatzaganian, Carina K Y Chan, Shawn Somerset
OBJECTIVE: Despite major advances in research on acute stroke care interventions, relatively few stroke patients benefit from evidence-based care due to multiple barriers. Yet current evidence of such barriers is predominantly from high-income countries. This study seeks to understand stroke care professionals' views on the barriers which hinder the provision of optimal acute stroke care in Ghanaian hospital settings. DESIGN: A qualitative approach using semistructured interviews...
April 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28449396/exploring-guideline-adaptation-strategy-for-turkey-is-adapte-feasible-or-does-it-need-adaptation-as-well
#18
Duygu Ayhan Baser, Rabia Kahveci, Aylin Baydar Artantas, İlknur Yasar, Hilal Aksoy, Esra Meltem Koc, İsmail Kasim, Ilkka Kunnamo, Adem Özkara
RATIONALE, AIMS, OBJECTIVES: Clinical Practice Guidelines are mostly developed by 3 methods; namely, de novo, adoption, and adaptation. Nonpublished studies and authors experience shows that most guidelines in Turkey are either by adoption or by adaptation. There is no available local tool for adaptation, so the process is not standardized and most of the time not explicitly defined. The objective of this study is to search for international guideline adaptation tools and test their feasibility in Turkish context, to serve a final goal of developing a unique local strategic tool for guideline adaptation...
April 27, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28447968/protective-effects-of-ursodeoxycholic-acid-in-experimental-corrosive-esophagitis-injury-in-rats
#19
Adem Ku Çu K, Naci Topaloglu, Sule Yildirim, Mustafa Tekin, Mesut Erbas, Hasan Ali Kiraz, Havva Erdem, Aybars Özkan
Accidental caustic ingestions are serious medical problems especially in childhood. Various treatment modalities are being used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats. Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in three groups randomly: UDCA treatment group (Group T, n:8), control group (Group K, n: 8) and sham group (Group S, n: 8)...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28445083/fatigue-and-physical-functioning-in-children-with-multiple-sclerosis-and-acute-disseminated-encephalomyelitis
#20
Leontien Cc Toussaint-Duyster, Yu Yi M Wong, Monique Hm Van der Cammen-van Zijp, Daniëlle Van Pelt-Gravesteijn, Coriene E Catsman-Berrevoets, Rogier Q Hintzen, Rinze F Neuteboom
BACKGROUND AND OBJECTIVE: Fatigue and physical impairments are a major concern in children with multiple sclerosis (MS) and after acute disseminated encephalomyelitis (post-ADEM). We here aimed to evaluate the interaction between fatigue, exercise capacity, motor performance, neurological status, and quality of life (HRQoL). METHODS: In this cross-sectional study, data of 38 children (MS n = 22, post-ADEM n = 16), aged 4-17 years attending our national pediatric MS center, were studied...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
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