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https://www.readbyqxmd.com/read/28102754/enhancement-of-antibody-functions-through-fc-multiplications
#1
Qun Wang, Yan Chen, Mark Pelletier, Romana Cvitkovic, Jessica Bonnell, Chien-Ying Chang, Adem C Koksal, Ellen O'Connor, Xizhe Gao, Xiang-Qing Yu, Herren Wu, C Kendall Stover, William F Dall'Acqua, Xiaodong Xiao
Antibodies carry out a plethora of functions through their crystallizable fragment (Fc) regions, which can be naturally tuned by the adoption of several isotypes and post-translational modifications. Protein engineering enables further Fc function modulations through modifications of the interactions between the Fc and its functional partners, including FcγR, FcRn, complement complex, and additions of auxiliary functional units. Due to the many functions embedded within the confinement of an Fc, a suitable balance must be maintained for a therapeutic antibody to be effective and safe...
January 19, 2017: MAbs
https://www.readbyqxmd.com/read/28096835/left-atrial-appendage-mass-is-it-always-a-thrombus
#2
Hikmet Sahratov, Adem Guler, Mustafa Kurkluoglu, Fahri Gurkan Yesil, Murat Tavlasoglu, Faruk Cingoz
Myxoma is the most common benign tumor of the heart, but it is very rare for it to originate from the left atrial appendage. Distinguishing between a mass, a thrombus, and a tumor in the body of the left atrium with preoperative transthoracic or transesophageal echocardiography is very difficult, even more so in patients with mitral valve disease and chronic atrial fibrillation. A 50-year-old male patient was admitted for surgery with the diagnosis of mitral stenosis and chronic atrial fibrillation. Transesophageal echocardiography demonstrated a mass attached to the wall of the left atrial appendage...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28065972/management-of-root-resorption-with-mineral-trioxide-aggregate-complicated-by-a-luxation-injury-report-of-a-case-with-six-year-follow-up
#3
Adem Kusgoz, Tahsin Yildirim, Cemile Kedici Alp, Mehmet Tanriver
Trauma to the oral region occurs frequently, comprising 5% of all injuries. The most common dental injuries are lateral luxations which can be seen with a prevalence of up to 27% among dental injuries. Ectopic eruption of maxillary canines can lead to root resorption on maxillary lateral incisors especially on apical and middle thirds of the roots. Half of these resorbed lateral incisors show severe resorption, in which the pulp is exposed. This case report describes non-surgical treatment with mineral trioxide aggregate (MTA) and a six-year follow-up of a maxillary lateral incisor, resorbed by ectopic eruption of the canine and affected by lateral luxation injury...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28060763/comparison-of-the-tumor-cell-secretome-and-patient-sera-for-an-accurate-serum-based-diagnosis-of-pancreatic-ductal-adenocarcinoma
#4
Shakhawan Mustafa, Longqiang Pan, Aseel Marzoq, Malak Fawaz, Laureen Sander, Felix Rückert, Andrea Schrenk, Christina Hartl, Rico Uhler, Adem Yildirim, Oliver Strobel, Thilo Hackert, Nathalia Giese, Markus W Büchler, Jörg D Hoheisel, Mohamed Saiel Saeed Alhamdani
Pancreatic cancer is the currently most lethal malignancy. Toward an accurate diagnosis of the disease in body liquids, we studied the protein composition of the secretomes of 16 primary and established cell lines of pancreatic ductal adenocarcinoma (PDAC). Compared to the secretome of non-tumorous cells, 112 proteins exhibited significantly different abundances. Functionally, the proteins were associated with PDAC features, such as decreased apoptosis, better cell survival and immune cell regulation. The result was compared to profiles obtained from 164 serum samples from two independent cohorts - a training and a test set - of patients with PDAC or chronic pancreatitis and healthy donors...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28058161/posterior-capsular-opacification-in-preschool-and-school-age-patients-after-pediatric-cataract-surgery-without-posterior-capsulotomy
#5
Muhammed Batur, Adem Gül, Erbil Seven, Ertuğrul Can, Tekin Yaşar
OBJECTIVES: We aimed to evaluate the development of posterior capsular opacification (PCO) in preschool- and school-age children with cataract who underwent cataract surgery without posterior capsulotomy and anterior vitrectomy. MATERIALS AND METHODS: The records of 30 eyes of 21 patients who underwent pediatric cataract surgery and intraocular lens (IOL) implantation were retrospectively reviewed. Patients' age, PCO status and duration, need for neodymium-doped yttrium aluminium garnet (Nd:YAG) laser treatment based on coverage of visual axis, and follow-up period were recorded...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057865/cocapture-of-cognate-and-bystander-antigens-can-activate-autoreactive-b-cells
#6
Nicholas S R Sanderson, Maria Zimmermann, Luca Eilinger, Céline Gubser, Nicole Schaeren-Wiemers, Raija L P Lindberg, Stephanie K Dougan, Hidde L Ploegh, Ludwig Kappos, Tobias Derfuss
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with autoimmune central nervous system diseases like acute disseminated encephalomyelitis (ADEM). For ADEM, it is speculated that a preceding infection is the trigger of the autoimmune response, but the mechanism connecting the infection to the production of MOG antibodies remains a mystery. We reasoned that the ability of B cells to capture cognate antigen from cell membranes, along with small quantities of coexpressed "bystander" antigens, might enable B-cell escape from tolerance...
January 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28056701/rivaroxaban-vs-warfarin-on-extended-deep-venous-thromboembolism-treatment-a-cost-analysis
#7
Adem I Diken, Adnan Yalçınkaya, Muhammet O Hanedan, Mehmet E Erol, Özlem Ercen Diken
Background Standard treatment for deep venous thromboembolism involves parenteral anticoagulation overlapping with a vitamin K antagonist, an approach that is effective but associated with limitations including the need for frequent coagulation monitoring. The direct oral anticoagulant rivaroxaban is similarly effective to standard therapy as a single-drug treatment for venous thromboembolism and does not require routine coagulation monitoring. The aim of this analysis was to project the long-term costs and outcomes for rivaroxaban compared to standard of care (tinzaparin/warfarin)...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28045424/case-images-pulmonary-hypertension-due-to-left-upper-lobe-partial-anomalous-pulmonary-venous-return
#8
Semi Öztürk, Muhsin Kalyoncuoğlu, Gündüz Durmuş, Adem Topçu, Mehmet Can
No abstract text is available yet for this article.
December 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28045413/vitamin-d-levels-predict-the-response-to-cardiac-resynchronization-therapy-in-patients-with-systolic-heart-failure
#9
Hamza Sunman, Adem Özkan, Hikmet Yorgun, Uğur Canpolat, Naresh Maharjan, Serkan Asil, Ergün Barış Kaya, Tülin Bayrak, Lale Tokgözoğlu, Asuman Özkara, Kudret Aytemir, Ali Oto
OBJECTIVE: The aim of this study was to examine the relationship between vitamin D levels in patients with heart failure (HF) and response to cardiac resynchronization therapy (CRT). METHODS: We studied 57 patients (mean age: 60.47±13.09 years) with New York Heart Association Class II or III heart failure, QRS duration ?120 milliseconds, and ejection fraction <35% (mean: 27.1±4.4%) who underwent CRT. All patients were taking optimal medical treatment for HF...
December 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28033501/investigation-of-holdup-and-axial-dispersion-of-liquid-phase-in-a-catalytic-exchange-column-using-radiotracer-technique
#10
Rajesh Kumar, H J Pant, Sunil Goswami, V K Sharma, A Dash, S Mishra, K Bhanja, Sadhana Mohan, S M Mahajani
Holdup and axial dispersion of liquid phase in a catalytic exchange column were investigated by measuring residence time distributions (RTD) using a radiotracer technique. RTD experiments were independently carried out with two different types of packings i.e. hydrophobic water-repellent supported platinum catalyst and a mixture (50% (v/v)) of hydrophobic catalyst and a hydrophillic wettable packing were used in the column. Mean residence times and hold-ups of the liquid phase were estimated at different operating conditions...
December 7, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28024772/effects-of-casein-phosphopeptide-amorphous-calcium-phosphate-application-after-interproximal-stripping-on-enamel-surface-an-in-vivo-study
#11
Mehmet Bayram, Adem Kusgoz, Cemal Yesilyurt, Metin Nur
INTRODUCTION: The aim of this study was to investigate the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) application after interproximal stripping on enamel surface structures in vivo. METHODS: Fifteen patients with a mean age of 15.8 years participated in this study. For each patient, the extraction of 4 first premolars was part of the orthodontic treatment plan. The patients were randomly divided into 5 groups of 3 patients. With the exception of group 1, the mesial and distal surfaces of all first premolars were stripped with a stripping disc (Komet; Gebr Brasseler, Lemgo, Germany) under air cooling and then polished with Sof-Lex polishing discs (3M Dental Products, St Paul, Minn)...
January 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28009963/a-new-artificial-chordae-implantation-method-in-mitral-valve-surgery
#12
Murat Tavlasoglu, Adem Guler, Hikmet Sahratov, Faruk Cingoz, Turgay Çelik
A novel method is described for artificial chordae replacement with expanded polytetrafluoroethylene suture in mitral valve repair procedures. The technique does not involve knots over or beneath the free edge of the mitral valve leaflets. Artificial chords suspend the exact free margin of leaflets as if it were a continuation of the free margin, such that the smooth zone of the coapting area can be preserved. This technique is simple, reproducible, and applicable to both anterior and posterior leaflets. Moreover, the length of the artificial chords can be adjusted rapidly and accurately at the first attempt...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28009079/acute-disseminated-encephalomyelitis-in-china-singapore-and-japan-a-comparison-with-the-usa
#13
D L H Koelman, D C Benkeser, Y Xu, S X Neo, K Tan, M Katsuno, G Sobue, J Natsume, S Chahin, S S Mar, A Venkatesan, T Chitnis, G M Hoganson, A K Yeshokumar, P Barreras, B Majmudar, M Carone, F J Mateen
BACKGROUND AND PURPOSE: Ethnicity-related differences in the incidence of acute disseminated encephalomyelitis (ADEM) and other demyelinating diseases including multiple sclerosis and neuromyelitis optica spectrum disorders have been reported. Little is reported on the influence of ethnicity and geographical location in ADEM. METHODS: Medical records of patients who presented with ADEM (ICD-9 323.61 and 323.81) at large referral hospitals in China, Singapore and Japan (years 1992-2015) were retrospectively reviewed and data were collected in a centralized database...
February 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28007603/inverse-association-between-basilar-arterial-volume-and-neuron-density-in-the-stellate-ganglion-following-bilateral-common-carotid-artery-ligation-an-experimental-study
#14
Ilhan Yilmaz, Metehan Eseoglu, Mehmet Resid Onen, Osman Tanrıverdi, Mustafa Kilic, Adem Yilmaz, Ahmet Murat Musluman, Mehmet Dumlu Aydin, Cemal Gündogdu
This study examined the relationship between neuron density in the stellate ganglion and the severity of basilar artery enlargement after bilateral common carotid artery ligation (BCCAL). Rabbits (n=24) were randomly divided into three groups: an unoperated control group (n=4); an experimental group subjected to BCCAL (n=15); and a sham-operated control group (n=5). A histological examination of the basilar arteries and stellate ganglia was performed 2 months later. Permanent BCCAL was induced by ligation of common carotid arteries at prebifurcation levels as a model for stenoocclusive carotid artery disease...
December 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28007050/an-adverse-drug-event-manager-facilitates-spontaneous-reporting-of-adverse-drug-reactions
#15
Siri Vinther, Pia Klarskov, Hanne Borgeskov, Perle Darsø, Anette Kvindebjerg Christophersen, Bille Borck, Catrine Christensen, Melissa Voigt Hansen, Natalie Monica Løvland Halladin, Mikkel Bring Christensen, Kirstine Moll Harboe, Marie Lund, Espen Jimenez-Solem
INTRODUCTION: Spontaneous reporting of adverse drug reactions (ADRs) is used for continuous risk-benefit evaluation of marketed pharmaceutical products and for signal detection. The Adverse Drug Event Manager (ADEM) is a service offered to clinicians employed at hospitals in the Capital Region of Denmark. The ADEM assists healthcare professionals in reporting suspected ADRs to the Danish Health Authority. The aim of this retrospective observational study was to quantify and describe ADRs reported via the ADEM in 2014...
January 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/27999591/endoscopic-management-of-the-difficult-bile-duct-stones-a-single-tertiary-center-experience
#16
Bülent Ödemiş, Ufuk Barış Kuzu, Erkin Öztaş, Fatih Saygılı, Nuretdin Suna, Orhan Coskun, Adem Aksoy, Zeliha Sırtaş, Derya Arı, Yener Akpınar
Background. Most common bile duct (CBD) stones can be removed with standard techniques using endoscopic retrograde cholangiopancreatography (ERCP), but in some cases additional methods are needed. In this study we aimed to investigate the management of patients with difficult stones and the factors that affect the outcome of patients that have undergone periodic endobiliary stenting. Materials and Methods. Data of 1529 patients with naive papilla who had undergone ERCP with an indication of CBD stones was evaluated retrospectively...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27991641/acoustic-actuation-of-bioinspired-microswimmers
#17
Murat Kaynak, Adem Ozcelik, Amir Nourhani, Paul E Lammert, Vincent H Crespi, Tony Jun Huang
Acoustic actuation of bioinspired microswimmers is experimentally demonstrated. Microswimmers are fabricated in situ in a microchannel. Upon acoustic excitation, the flagellum of the microswimmer oscillates, which in turn generates linear or rotary movement depending on the swimmer design. The speed of these bioinspired microswimmers is tuned by adjusting the voltage amplitude applied to the acoustic transducer. Simple microfabrication and remote actuation are promising for biomedical applications.
December 19, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27978852/phylogenetic-analysis-of-haemaphysalis-erinacei-pavesi-1884-acari-ixodidae-from-china-turkey-italy-and-romania
#18
Sándor Hornok, Yuanzhi Wang, Domenico Otranto, Adem Keskin, Riccardo Paolo Lia, Jenő Kontschán, Nóra Takács, Róbert Farkas, Attila D Sándor
BACKGROUND: Haemaphysalis erinacei is one of the few ixodid tick species for which valid names of subspecies exist. Despite their disputed taxonomic status in the literature, these subspecies have not yet been compared with molecular methods. The aim of the present study was to investigate the phylogenetic relationships of H. erinacei subspecies, in the context of the first finding of this tick species in Romania. RESULTS: After morphological identification, DNA was extracted from five adults of H...
December 15, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27976568/an-unexpected-diagnostic-course-of-systemic-lupus-erythematosus
#19
Aysel Taktak, Adem Köksoy, Özge Başaran, Saba Kiremitçi, Banu Acar, Nermin Uncu, Nilgün Çakar
Thrombotic microangiopathy (TM), especially thrombotic thrombocytopenic purpura (TTP) is described in systemic lupus erythematosus (SLE) as a severe hematological involvement. However hemolytic uremic syndrome (HUS) is seen less frequently in SLE, particularly as an initial presentation. Here we present a 15-year old boy presenting with gross hematuria, decreased urinary output and petechial lesions. He was diagnosed as atypical HUS according to the classical triad of TM, along with observation of hypocomplementemia and negative stool cultures...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27970260/tct-95-the-interplay-between-features-of-plaque-vulnerability-and-hemodynamic-relevance-of-coronary-artery-stenoses
#20
Sabahattin Umman, Berrin Umman, Emre Aslanger, Adem Atici, Zehra Bugra, Murat Sezer
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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