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https://www.readbyqxmd.com/read/28441706/a-comprehensive-model-for-predicting-recurrence-and-survival-in-cases-of-chinese-postoperative-invasive-breast-cancer
#1
Xianhe Xie, Yanfen Hu, Chao Jing, Shuimei Luo, Yunfu Lv, Haitao Yang, Lina Li, Huijuan Chen, Wanzun Lin, Weili Zheng
We investigated relationships between clinical pathologic data, molecular biomarkers and prognosis of invasive breast cancer based on a Chinese population. Immunohistochemistry (IHC) was used to assess the status of ER, PR, HER-2 and Ki-67, with fluorescence in situ hybridization (FISH) performed to further confirm HER-2 positivity with an equivocal result (IHC 2+). Subsequently, Kaplan-Meier univariate and multivariate COX regression analyses of ER, PR, HER-2, Ki-67, clinical features, therapeutic status and follow-up data were performed according to the establishment principle of the Nottingham prognostic index (NPI)...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441682/chondrosarcoma-of-the-osseous-spine-an-analysis-of-epidemiology-patient-outcomes-and-prognostic-factors-using-the-seer-registry-from-1973-to-2012
#2
Armin Arshi, Justin Sharim, Don Y Park, Howard Y Park, Nicholas M Bernthal, Hamed Yazdanshenas, Arya N Shamie
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To determine the epidemiology and prognostic indicators in patients with chondrosarcoma of the osseous spine. SUMMARY OF BACKGROUND DATA: Chondrosarcoma of the spine is rare, with limited data on its epidemiology, clinicopathologic features, and treatment outcomes. Therapy centers on complete en bloc resection with radiotherapy reserved for subtotal resection or advanced disease. METHODS: The Surveillance, Epidemiology, and End Results Registry was queried for patients with chondrosarcoma of the osseous spine from 1973 to 2012...
May 1, 2017: Spine
https://www.readbyqxmd.com/read/28441428/increased-long-term-risk-of-major-adverse-cardiovascular-events-in-patients-with-carbon-monoxide-poisoning-a-population-based-study-in-taiwan
#3
Chung-Shun Wong, Ying-Chin Lin, Li-Chin Sung, Tzu-Ting Chen, Hon-Ping Ma, Yung-Ho Hsu, Shin-Han Tsai, Yuh-Feng Lin, Mei-Yi Wu
BACKGROUND: Carbon monoxide (CO) poisoning may cause toxicity to the cardiovascular system. However, the association between CO poisoning and the risk of major adverse cardiovascular events (MACE) remains unestablished. We investigated the incidence of MACE after CO poisoning in Taiwan and evaluated whether CO-poisoned individuals had a higher risk of MACE than did the general population. METHODS: Using Taiwan's National Health Insurance Research Database (NHIRD) during 2005-2013, a nationwide population-based cohort study was conducted among patients who experienced CO poisoning between 2005 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28441251/prognostic-role-of-histological-tumor-regression-in-patients-receiving-neoadjuvant-chemotherapy-for-high-grade-serous-tubo-ovarian-carcinoma
#4
Edwina Coghlan, Tarek M Meniawy, Aime Munro, Max Bulsara, Colin Jr Stewart, Adeline Tan, M H Eleanor Koay, Daniel MaGee, Jim Codde, Jason Tan, Stuart G Salfinger, Ganendra R Mohan, Yee Leung, Cassandra B Nichols, Paul A Cohen
OBJECTIVE: Our objective was to validate the prognostic role of the chemotherapy response score (CRS), which has been proposed for measuring tumor response to neoadjuvant chemotherapy in patients with high-grade serous tubo-ovarian carcinoma, in predicting progression-free survival (PFS) and overall survival (OS). METHODS: A retrospective cohort study was conducted of patients with advanced high-grade serous tubo-ovarian carcinoma diagnosed between January 1, 2010, and December 31, 2014, and treated with neoadjuvant chemotherapy...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28441088/video-enabled-cue-exposure-based-intervention-improves-postdischarge-drinking-outcomes-among-alcohol-dependent-men-a-prospective-study-at-a-government-addiction-treatment-setting-in-india
#5
Prasanthi Nattala, Pratima Murthy, Kit Sang Leung, Sreevani Rentala, Jayashree Ramakrishna
Returning to alcohol use following inpatient treatment occurs due to various real life cues/triggers. It is a challenge to demonstrate to patients how to deal with these triggers during inpatient treatment. Aims of the current study were (a) to evaluate the effectiveness of video-enabled cue-exposure-based intervention (VE-CEI) in influencing treatment outcomes in alcohol dependence, (b) to identify postdischarge predictors of intervention failure (returning to ≥50% of baseline alcohol consumption quantity/day)...
April 25, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28440971/prognostic-factors-for-large-symptomatic-gists-a-pragmatic-study-of-experiences-from-a-university-hospital-over-10-years
#6
Supatcha Prasertcharoensuk, Punnapud Thanapongpornthana, Vajarabhongsa Bhudhisawasdi, Ake Pugkhem, Kriangsak Jenwitheesuk, Aumkhae Sookprasert, Chawalit Pairojkul
Background: Gastrointestinal stromal tumors (GISTs), which are mesenchymal neoplasms in the gastrointestinal (GI) tract account for 0.2% of all GI tumors. Several factors have been reported (mostly from studies conducted in Western countries) to be associated with survival in GISTs cases such as tumor site, staging, and tumor size. We conducted a pragmatic study, looking at a 10-year period, aimed at understanding the prognostic factors related to GISTs in a university hospital. The study population consisted of patients with large symptomatic GISTs...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28440864/breast-cancer-stage-variation-and-survival-in-association-with-insurance-status-and-sociodemographic-factors-in-us-women-18-to-64-years-old
#7
Christine D Hsu, Xiaoyan Wang, David V Habif, Cynthia X Ma, Kimberly J Johnson
BACKGROUND: Few population-based studies have examined the association between health insurance status and breast cancer stage at diagnosis and survival. The degree to which sociodemographic characteristics explain this association is also unclear. This study examined associations between insurance status and sociodemographic characteristics and stage at diagnosis and survival. METHODS: Using the Surveillance, Epidemiology, and End Results 18 registries database, we identified 52,048 women aged 18 to 64 years who were diagnosed with breast cancer in 2007 and 2008...
April 25, 2017: Cancer
https://www.readbyqxmd.com/read/28440704/effect-of-femoral-head-size-and-surgical-approach-on-risk-of-revision-for-dislocation-after-total-hip-arthroplasty
#8
Wierd P Zijlstra, Bas De Hartog, Liza N Van Steenbergen, B Willem Scheurs, Rob G H H Nelissen
Background and purpose - Recurrent dislocation is the commonest cause of early revision of a total hip arthropasty (THA). We examined the effect of femoral head size and surgical approach on revision rate for dislocation, and for other reasons, after total hip arthroplasty (THA). Patients and methods - We analyzed data on 166,231 primary THAs and 3,754 subsequent revision THAs performed between 2007 and 2015, registered in the Dutch Arthroplasty Register (LROI). Revision rate for dislocation, and for all other causes, were calculated by competing-risk analysis at 6-year follow-up...
April 25, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28440568/impact-of-t-wave-amplitude-in-lead-avr-on-predicting-cardiac-events-in-ischemic-and-nonischemic-cardiomyopathy-patients-with-an-implantable-cardioverter-defibrillator
#9
Yoshihiro Tanaka, Tetsuo Konno, Yudai Tamura, Toyonobu Tsuda, Hiroshi Furusho, Masayuki Takamura, Kenji Sakata, Masakazu Yamagishi, Kenshi Hayashi
BACKGROUND: T wave amplitudes during ventricular repolarization in the lead aVR (TAaVR) are shown to be associated with adverse cardiac events in patients with several cardiovascular diseases, such as postmyocardial infarction. However, the utility of TAaVR has not been previously evaluated in patients with cardiomyopathy who have received implantable cardioverter defibrillators (ICD). Patients with ischemic or nonischemic cardiomyopathy (ICM or NICM, respectively) and who received an ICD may experience worsening of their condition due to the introduction of electric shock during treatment...
April 25, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28440527/-predictive-value-of-combination-detection-of-tissue-pgp1-expression-and-preoperative-serum-cea-level-for-colorectal-cancer
#10
Fan Wu, Lei Chen, Wei Wu, Beihai Jiang, Xiangqian Su
OBJECTIVE: To explore the predictive value of combination detection of Pgp1 expression in cancer tissue and serum CEA level for the prognosis of colorectal cancer (CRC) patients. METHODS: Clinicopathological data, complete 5-year follow-up data and CRC tissue samples of 153 CRC patients with stage I( to II( tumor undergoing radical operation in our department from January 2004 to August 2006 were retrospectively collected. Immunohistochemical staining was used to detect the expression level of Pgp1...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440399/%C3%AE-1-antitrypsin-promotes-lung-adenocarcinoma-metastasis-through-upregulating-fibronectin-expression
#11
Yan Li, Liyun Miao, Min Yu, Minke Shi, Yongsheng Wang, Jun Yang, Yonglong Xiao, Hourong Cai
α1-antitrypsin (AAT) has been recognized to be associated with lung adenocarcinoma metastasis. However, the mechanisms by which AAT promotes tumor metastasis remain to be investigated. Herein, we first examined AAT expression in a panel of formalin-fixed paraffin-embedded tumor tissues from 88 lung adenocarcinoma patients undergoing curative resection, using immunohistochemical methods. Lung adenocarcinoma patients with high AAT expression showed a significantly shorter overall survival compared to those with low AAT expression by Kaplan-Meier method (P=0...
April 18, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28440113/major-limb-outcomes-following-lower-extremity-endovascular-revascularization-in-patients-with-and-without-diabetes-mellitus
#12
Andrew N Shammas, Haekyung Jeon-Slaughter, Shirling Tsai, Houman Khalili, Mujtaba Ali, Hao Xu, Gerardo Rodriguez, Ian Cawich, Ehrin J Armstrong, Emmanouil S Brilakis, Subhash Banerjee
PURPOSE: To determine whether diabetes mellitus has an independent impact on major limb outcomes at 1 year after endovascular treatment of lower extremity peripheral artery disease (PAD). METHODS: The study involved 1906 consecutive patients (mean age 66 years; 1469 men) enrolled in the observational Excellence in Peripheral Artery Disease (XLPAD) registry ( ClinicalTrials.gov identifier NCT01904851) between January 2005 and October 2015 after undergoing index endovascular procedures in 2426 limbs for arterial occlusive disease...
April 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28440040/hypofractionated-short-course-radiotherapy-in-elderly-patients-with-glioblastoma-multiforme-an-analysis-of-the-national-cancer-database
#13
Kimberley S Mak, Ankit Agarwal, Muhammad M Qureshi, Minh Tam Truong
For elderly patients with glioblastoma multiforme (GBM), randomized trials have shown similar survival with hypofractionated short-course radiotherapy (SCRT) compared to conventionally fractionated long-course radiotherapy (LCRT). We evaluated the adoption of SCRT along with associated factors and survival in a national patient registry. Using the National Cancer Data Base (NCDB), we identified patients aged ≥70 years with GBM, diagnosed between 1998 and 2011, who received SCRT (34-42 Gy in 2.5-3.4 Gy fractions), or LCRT (58-63 Gy in 1...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28440036/a-tale-of-two-countries-all-cause-mortality-among-people-living-with-hiv-and-receiving-combination-antiretroviral-therapy-in-the-uk-and-canada
#14
S Patterson, S Jose, H Samji, A Cescon, E Ding, J Zhu, J Anderson, A N Burchell, C Cooper, T Hill, M Hull, M B Klein, M Loutfy, F Martin, N Machouf, Jsg Montaner, M Nelson, J Raboud, S B Rourke, C Tsoukas, R S Hogg, C Sabin
OBJECTIVES: We sought to compare all-cause mortality of people living with HIV and accessing care in Canada and the UK. METHODS: Individuals from the Canadian Observational Cohort (CANOC) collaboration and UK Collaborative HIV Cohort (UK CHIC) study who were aged ≥ 18 years, had initiated antiretroviral therapy (ART) for the first time between 2000 and 2012 and who had acquired HIV through sexual transmission were included in the analysis. Cox regression was used to investigate the difference in mortality risk between the two cohort collaborations, accounting for loss to follow-up as a competing risk...
April 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28439957/prognostic-indicators-in-pediatric-clinically-isolated-syndrome
#15
Pietro Iaffaldano, Marta Simone, Giuseppe Lucisano, Angelo Ghezzi, Gabriella Coniglio, Vincenzo Brescia Morra, Giuseppe Salemi, Francesco Patti, Alessandra Lugaresi, Guillermo Izquierdo, Roberto Bergamaschi, Jose Antonio Cabrera-Gomez, Carlo Pozzilli, Enrico Millefiorini, Raed Alroughani, Cavit Boz, Eugenio Pucci, Giovanni Bosco Zimatore, Patrizia Sola, Giacomo Lus, Davide Maimone, Carlo Avolio, Eleonora Cocco, Seyed Aidin Sajedi, Gianfranco Costantino, Pierre Duquette, Vahid Shaygannejad, Thor Petersen, Ricardo Fernández Bolaños, Damiano Paolicelli, Carla Tortorella, Tim Spelman, Lucia Margari, Maria Pia Amato, Giancarlo Comi, Helmut Butzkueven, Maria Trojano
OBJECTIVE: To assess prognostic factors for a second clinical attack and a first disability worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of Multiple Sclerosis (MS) patients. METHODS: A cohort of 770 pCIS patients was followed-up for at least 10 years. Cox proportional hazard models and RECursive Partitioning and AMalgamation (RECPAM) tree-regression were used to analyze data. RESULTS: In pCIS, female sex and a multifocal onset were risk factors for a second clinical attack (HR, 95% CI: 1...
April 25, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28439955/recurrent-venous-thrombosis-related-to-overweight-and-obesity-results-from-the-mega-follow-up-study
#16
B A Vučković, S C Cannegieter, A van Hylckama Vlieg, F R Rosendaal, W M Lijfering
BACKGROUND: Studies on the risk of recurrent venous thrombosis in patients with excess body weight have yielded conflicting results. OBJECTIVE: To estimate whether excess body weight increases the risk of recurrent venous thrombosis. PATIENTS/METHODS: We included 3 889 patients, followed after a first venous thrombosis for a median of 5.6 years. Body mass index (BMI) was calculated as weight in kilograms/height in meters squared, and classified according to three a-priori defined categories (normal weight/overweight/obesity), as well as by percentiles...
April 25, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28439760/prognostic-study-of-cardiac-events-in-japanese-patients-with-chronic-kidney-disease-using-ecg-gated-myocardial-perfusion-imaging-final-3-year-report-of-the-j-access-3-study
#17
Satoko Nakamura, Yuhei Kawano, Kenichi Nakajima, Hiroki Hase, Nobuhiko Joki, Tsuguru Hatta, Shigeyuki Nishimura, Masao Moroi, Susumu Nakagawa, Tokuo Kasai, Hideo Kusuoka, Yasuchika Takeishi, Mitsuru Momose, Kazuya Takehana, Mamoru Nanasato, Syunichi Yoda, Hidetaka Nishina, Naoya Matsumoto, Tsunehiko Nishimura
BACKGROUND: Myocardial perfusion imaging (MPI) is considered useful for risk stratification among patients with chronic kidney disease (CKD), without renal deterioration by contrast media. METHODS AND RESULTS: The Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS 3) is a multicenter, prospective cohort study investigating the ability of MPI to predict cardiac events in 529 CKD patients without a definitive coronary artery disease...
April 24, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28438901/systolic-blood-pressure-and-vascular-disease-in-men-aged-65-years-and-over-the-hims-health-in-men-study
#18
Ben Lacey, Jonathan Golledge, Bu B Yeap, Sarah Lewington, Kieran A McCaul, Paul E Norman, Leon Flicker, Osvaldo P Almeida, Graeme J Hankey
There is uncertainty about the relation between blood pressure and vascular disease at older age. We assessed the association of systolic blood pressure (SBP) and major vascular events in a prospective cohort study of 7564 men aged 65 to 94 years, recruited in 1996-1999 from the general population in Perth, Western Australia. SBP was measured at baseline and again at resurvey in 2001-2004. Participants were monitored for fatal and nonfatal vascular events. To limit the effect of reverse causality, analyses were restricted to men without previous vascular disease at baseline...
April 24, 2017: Hypertension
https://www.readbyqxmd.com/read/28438738/short-length-of-stay-after-elective-transfemoral-transcatheter-aortic-valve-replacement-is-not-associated-with-increased-early-or-late-readmission-risk
#19
Maneesh Sud, Feng Qui, Peter C Austin, Dennis T Ko, David Wood, Andrew Czarnecki, Vaidehi Patel, Douglas S Lee, Harindra C Wijeysundera
BACKGROUND: Elderly patients undergoing transcatheter aortic valve replacement (TAVR) are at risk of hospital readmission postprocedure. It is not known whether the index hospital length of stay and, specifically, early discharge post-TAVR is associated with an increased risk of readmission. We hypothesized a nonlinear relationship whereby both short and long lengths of stay were associated with increased readmission risk. METHODS AND RESULTS: We performed a retrospective multicenter cohort analysis of patients undergoing elective transfemoral TAVR and surviving to discharge between January 2007 and March 2014...
April 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28438547/metformin-is-associated-with-a-lower-risk-of-colorectal-cancer-in-taiwanese-patients-with-type-2-diabetes-a-retrospective-cohort-analysis
#20
C-H Tseng
BACKGROUND: The association between metformin and colorectal cancer (CRC) has rarely been investigated in Asian populations. METHODS: This retrospective cohort study included patients with newly diagnosed type 2 diabetes during 1999-2005, recruited from Taiwan's National Health Insurance database. A total of 169,601 patients (original cohort: 153,270 ever-users and 16,331 never-users of metformin) and a subgroup of 1:1 propensity-score-matched pairs of 16,331 ever-users and 16,331 never-users (matched cohort) were followed up to 31 December 2011...
April 21, 2017: Diabetes & Metabolism
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