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https://www.readbyqxmd.com/read/29469770/interstitial-granulomatous-dermatitis-in-a-patient-with-chronic-hepatitis-c-and-mixed-cryoglobulinemia
#1
M Rato, F Gil, A F Monteiro, J Aranha, E Tavares
A 55-year-old man presented with a history of asymptomatic, bilateral, figurate dermatosis consisting of erythematous, annular, linear, andarciform, indurated nodules and plaques on the lateral walls of thorax, flanks, and hypogastrium. His medical history was positive for chronic hepatitis C. Skin biopsy was compatible with the diagnosisof interstitial granulomatous dermatitis. Additionalinvestigation revealed positive rheumatoid factor, antinuclear antibodies, and cryoglobulins. Thepatient started treatment with high-potency topical corticosteroid...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469217/effect-of-treatment-with-direct-acting-antivirals-on-body-mass-index-and-hepatic-steatosis-in-chronic-hepatitis-c
#2
Hend Ibrahim Shousha, Rasha Ahmed Abdelaziz, Sherief Musa Azab, Marwa Khairy, Shahira Ahmed Afifi, Mai Ismael Mehrez, Mohamed Ali Eshra, Ayman Yosry Abdelrahim
BACKGROUND: Direct Acting Agents (DAAs) have high cure rate but still lack the knowledge of their effect on hepatic steatosis in chronic hepatitis C (CHC). Controlled Attenuation Parameter (CAP), evaluated with transient elastography, could help in assessment of steatosis grades. We aim to evaluate the effect of DAAs on BMI and steatosis in CHC using CAP. PATIENTS AND METHODS: This cohort study included 155 CHC Egyptian patients divided into three groups according to the DAAs regimens...
February 22, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29469034/early-successes-in-an-open-access-provincially-funded-hepatitis-c-treatment-program-in-prince-edward-island
#3
Jordan W Francheville, Robin Rankin, Jeremy Beck, Connie Hoare, Stefanie Materniak, Greg German, Lisa Barrett, Natalie Bunimov-Wall, Daniel Smyth
INTRODUCTION: The availability of curative hepatitis C therapies has created an opportunity to improve treatment delivery and access. Local providers, government, industry, and community groups in Prince Edward Island developed an innovative province-wide care model. Our goal was to describe the first year of program implementation. MATERIAL AND METHODS: Using a communitybased prospective observational study design, all chronic hepatitis C referrals received from April 2015 to April 2016 were recorded in a database...
February 13, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29467758/predicting-early-viral-control-under-direct-acting-antiviral-therapy-for-chronic-hepatitis-c-virus-using-pretreatment-immunological-markers
#4
James A Hutchinson, Kilian Weigand, Akinbami Adenugba, Katharina Kronenberg, Jan Haarer, Florian Zeman, Paloma Riquelme, Matthias Hornung, Norbert Ahrens, Hans J Schlitt, Edward K Geissler, Jens M Werner
Recent introduction of all-oral direct-acting antiviral (DAA) treatment has revolutionized care of patients with chronic hepatitis C virus (HCV) infection. Regrettably, the high cost of DAA treatment is burdensome for healthcare systems and may be prohibitive for some patients who would otherwise benefit. Understanding how patient-related factors influence individual responses to DAA treatment may lead to more efficient prescribing. In this observational study, patients with chronic HCV infection were comprehensively monitored by flow cytometry to identify pretreatment immunological variables that predicted HCV RNA negativity within 4 weeks of commencing DAA treatment...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467555/predictors-of-functional-benefit-of-hepatitis-c-therapy-in-a-real-life-cohort
#5
Niels Steinebrunner, Kerstin Stein, Catharina Sandig, Thomas Bruckner, Wolfgang Stremmel, Anita Pathil
AIM: To define predictors of functional benefit of direct-acting antivirals (DAAs) in patients with chronic hepatitis C virus (HCV) infection and liver cirrhosis. METHODS: We analysed a cohort of 199 patients with chronic HCV genotype 1, 2, 3 and 4 infection involving previously treated and untreated patients with compensated (76%) and decompensated (24%) liver cirrhosis at two tertiary centres in Germany. Patients were included with treatment initiation between February 2014 and August 2016...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29467378/inform-software-a-semi-automated-research-tool-to-identify-presumptive-human-hepatic-progenitor-cells-and-other-histological-features-of-pathological-significance
#6
Anne S Kramer, Bruce Latham, Luke A Diepeveen, Lingjun Mou, Geoffrey J Laurent, Caryn Elsegood, Laura Ochoa-Callejero, George C Yeoh
Hepatic progenitor cells (HPCs) play an important regenerative role in acute and chronic liver pathologies. Liver disease research often necessitates the grading of disease severity, and pathologists' reports are the current gold-standard for assessment. However, it is often impractical to recruit pathologists in large cohort studies. In this study we utilise PerkinElmer's "InForm" software package to semi-automate the scoring of patient liver biopsies, and compare outputs to a pathologist's assessment...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467124/gastric-and-duodenal-ischaemia-after-transarterial-chemoembolisation-for-hepatocellular-carcinoma-an-unexpected-but-significant-complication
#7
Sai Pavan Chintalapati, Arpan Patel, Hari Conjeevaram
Transarterial chemoembolisation (TACE) is commonly used for unresectable intermediate-stage hepatocellular carcinoma (HCC). TACE is usually well-tolerated. We report a case of a patient who presented with a gastrointestinal bleed from TACE. A 64-year-old man presented with chronic hepatitis C cirrhosis and multifocal bilobar HCC. He had previously undergone multiple TACE sessions, radiofrequency ablation and stereotactic body radiation therapy. In the evening of his TACE procedure, he developed abdominal pain and haematemesis...
February 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29466917/cure-of-chronic-hepatitis-c-virus-infection-in-an-hiv-coinfected-patient-with-multiple-comorbidities-and-drug-interaction-challenges
#8
Hortensia Álvarez, Ana Mariño, Nieves Valcarce, Saye Khoo, Sanjay Bhagani, Jonathan Schapiro, Josep M Llibre
Curing hepatitis C virus (HCV) infection in patients harbouring multiple severe comorbidities is a medical challenge. Evidence-based data are lacking regarding HCV treatment with direct-acting antiviral regimens in particular populations of HCV/HIV-coinfected patients with cirrhosis and chronic kidney disease on haemodialysis. Here, we present the HCV treatment challenges facing a patient with HIV coinfection, prior failure of both HIV-1 and HCV therapy, cirrhosis, end-stage renal failure on haemodialysis, as well as management of drug-drug interactions, especially given the need to receive long-term amiodarone therapy...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29466415/revisiting-policy-on-chronic-hcv-treatment-under-the-thai-universal-health-coverage-an-economic-evaluation-and-budget-impact-analysis
#9
Waranya Rattanavipapong, Thunyarat Anothaisintawee, Yot Teerawattananon
Thailand is encountering challenges to introduce the high-cost sofosbuvir for chronic hepatitis C treatment as part of the Universal Health Care's benefit package. This study was conducted in respond to policy demand from the Thai government to assess the value for money and budget impact of introducing sofosbuvir-based regimens in the tax-based health insurance scheme. The Markov model was constructed to assess costs and benefits of the four treatment options that include: (i) current practice-peginterferon alfa (PEG) and ribavirin (RBV) for 24 weeks in genotype 3 and 48 weeks for other genotypes; (ii) Sofosbuvir plus peginterferon alfa and ribavirin (SOF+PEG-RBV) for 12 weeks; (iii) Sofosbuvir and daclatasvir (SOF+DCV) for 12 weeks; (iv) Sofosbuvir and ledipasvir (SOF+LDV) for 12 weeks for non-3 genotypes and SOF+PEG-RBV for 12 weeks for genotype 3 infection...
2018: PloS One
https://www.readbyqxmd.com/read/29465575/impact-of-vitamin-d-receptor-and-binding-protein-gene-polymorphisms-in-clinical-and-laboratory-data-of-hcv-patients-cross-sectional-study
#10
Letícia de Paula Scalioni, Betânia Rodrigues Dos Santos, Poli Mara Spritzer, Cristiane Alves Villela-Nogueira, Lia Laura Lewis-Ximenez, Priscila Pollo-Flores, Eliane Bordalo Cathalá Esberard, Carlos Eduardo Brandão-Mello, Elisabeth Lampe, Livia Melo Villar
Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC).A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (<20 ng/mL defined as deficient) and donated blood samples to allelic discrimination analysis using TaqMan assays...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465473/characteristics-of-patients-with-hepatitis-c-virus-related-chronic-liver-diseases-just-before-the-era-of-oral-direct-acting-antiviral-therapy-in-italy
#11
Evangelista Sagnelli, Tommaso Stroffolini, Caterina Sagnelli, Bruno Cacopardo, Angelo Andriulli, Sergio Babudieri, Nicola Coppola, Giovanni B Gaeta, Piero L Almasio
BACKGROUND: In 2017, oral direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection became available free of charge for all HCV-RNA-positive patients, irrespective of their fibrosis stage. AIM: The aim of this study was to evaluate the characteristics of HCV-related chronic liver disease (CLD) in Italy just before the introduction of DAA therapy. PATIENTS AND METHODS: Patients with CLD were enrolled in two national surveys conducted in 2001 and in 2014...
February 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29465262/glecaprevir-pibrentasvir-for-treatment-of-hepatitis-c
#12
Andres F Carrion, Paul Martin
Introduction Glecaprevir/pibrentasvir is a fixed-dose combination regimen of a new generation NS3/4A inhibitor and an NS5A inhibitor with potent antiviral activity against all hepatitis C virus (HCV) genotypes. This regimen offers a shorter course of therapy (8 weeks) for selected patients regardless of genotype and has demonstrated high virological efficacy for retreatment of individuals who previously failed an NS5A containing regimen. Glecaprevir and pibrentasvir are minimally excreted by the kidneys; thus this regimen can safely be used in individuals with severe chronic kidney disease, including those undergoing hemodialysis...
February 21, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29464815/hepatic-elastin-content-is-predictive-of-adverse-outcome-in-advanced-fibrotic-liver-disease
#13
Timothy James Kendall, Grace Elizabeth Dolman, Catherine Mary Duff, Emma Claire Paish, Abed Zaitoun, William Irving, Jonathan Andrew Fallowfield, Indra Neil Guha
AIMS: Needle biopsy remains essential for diagnosis in assessment of liver disease, although there remains associated risk. Examination is largely limited to subjective evaluation and biopsies are not exploited to provide personalised prognostic information. Elastin is a durable component of fibrotic matrix in chronic disease, conferring resistance to remodelling and potentially influencing tissue biomechanics linked to portal hypertension. We hypothesised that elastin content was predictive of clinical outcome and so could be quantified to increase the beneficial information yield from a liver biopsy...
February 21, 2018: Histopathology
https://www.readbyqxmd.com/read/29463026/the-nile-rat-arvicanthis-niloticus-as-a-superior-carbohydrate-sensitive-model-for-type-2-diabetes-mellitus-t2dm
#14
REVIEW
Avinaash Subramaniam, Michelle Landstrom, Alice Luu, K C Hayes
Type II diabetes mellitus (T2DM) is a multifactorial disease involving complex genetic and environmental interactions. No single animal model has so far mirrored all the characteristics or complications of diabetes in humans. Since this disease represents a chronic nutritional insult based on a diet bearing a high glycemic load, the ideal model should recapitulate the underlying dietary issues. Most rodent models have three shortcomings: (1) they are genetically or chemically modified to produce diabetes; (2) unlike humans, most require high-fat feeding; (3) and they take too long to develop diabetes...
February 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29461687/efficacy-of-elbasvir-and-grazoprevir-in-participants-with-hepatitis-c-virus-genotype-4-infection-a-pooled-analysis
#15
Tarik Asselah, Hendrik Reesink, Jan Gerstoft, Victor de Ledinghen, Paul J Pockros, Michael Robertson, Peggy Hwang, Ernest Asante-Appiah, Janice Wahl, Bach-Yen Nguyen, Eliav Barr, Rohit Talwani, Lawrence Serfaty
BACKGROUND & AIMS: The aim of this integrated analysis was to assess the efficacy of the once-daily combination of elbasvir (EBR) 50 mg and grazoprevir (GZR) 100 mg, with and without ribavirin (RBV) in HCV genotype 4 (GT4)-infected participants enrolled in the Phase 2/3 clinical program with EBR/GZR. METHODS: Treatment-naïve and treatment-experienced participants 18 years of age or older with chronic HCV GT4 infection and baseline HCV RNA ≥10,000 IU/mL were included in the analysis...
February 20, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29461238/effective-treatment-of-chronic-hepatitis-c-virus-infections-with-direct-acting-antivirals-in-prisons-system
#16
E Vashakidze, T Imnadze, I Mikadze
Hepatitis C is a widespread infectious disorder, accounting for chronic hepatic inflammatory condition - hepatitis, hepatic cirrhosis and hepatocellular carcinoma throughout the world. In Georgia, where the incidence of HCV infection in population is highest among eastern European countries, hepatitis C represents one the most actual problems of healthcare system. The aim of the study was to identify the efficacy of antiviral therapy and management of side effects in HCV infected patients. In the patients under observation with type I genotype, the rapid viral response (RVR) was negative in 100%...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29459814/-porphyria-cutanea-tarda-as-extrahepatic-manifestation-of-chronic-hepatitis-c-a-case-report
#17
Jorge Espinoza-Ríos, Vanessa Valenzuela Granados, Manuel Ojeda Cisneros, Aldo Gálvez Canseco, Cesar Ramos Aguilar, Brunella Raymundo Villalva, Victor Aguilar Sánchez, José Pinto Valdivia, Jorge Huerta-Mercado Tenorio, Alejandro Bussalleu Rivera
The present case is a 56 year old male who present hyperpigmented and hypopigmented scars in both hands, associated with the presence of milia cysts. It was studied the metabolism of porphyrins and skin biopsy of the lesions which were compatible with porphyria cutanea tarda. In the initial laboratory, elevated transaminases values were found and subsequently identified chronic infection of hepatitis C virus. In order to treat viral infection and resolve the dermal commitment; considered extrahepatic manifestation of hepatitis C virus, treatment was started with pegylated interferon and ribavirin, with favorably development and rapid viral response, with undetectable viral load until now (24 weeks of treatment), decreased level of serum transaminases and improvement of skin lesions...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29459562/-the-impact-of-direct-acting-antiviral-therapy-on-the-diagnosis-of-hepatitis-c-virus-associated-hepatocellular-carcinoma
#18
Aya Takahashi, Toshihide Shima, Naohiko Kinoshita, Kota Yano, Tomoko Ueno, Masatake Nishiwaki, Yasuhide Yamamoto, Hirohisa Oya, Ichiro Amano, Junko Matsumoto, Yasuhide Mitsumoto, Izumi Tanaka, Kyoko Sakai, Naoki Sawai, Chiemi Mizuno, Masayuki Mizuno, Yoshito Itoh, Takeshi Okanoue
Since the introduction of direct-acting antiviral (DAA)-based combination therapies in September 2014 for patients with chronic hepatitis-C (CH-C), numerous patients have been diagnosed with hepatitis-C virus (HCV)-associated hepatocellular carcinomas (HCCs) during the screening performed prior to DAA therapy. The present study was conducted on the antiviral therapy for CH-C in two phases:i) the interferon (IFN) phase between January 2011 and August 2014 and ii) the DAA phase between September 2014 and September 2016...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29459165/house-sparrow-biomarkers-as-lead-pollution-bioindicators-evaluation-of-dose-and-exposition-length-on-hematological-and-oxidative-stress-parameters
#19
Fabricio D Cid, Noelia C Fernández, María V Pérez-Chaca, Rafael Pardo, Enrique Caviedes-Vidal, Juan G Chediack
House sparrows (Passer domesticus) have been proposed as a key ecological indicator of urban pollution. Remarkably, we lack knowledge about the physiological effects of lead on this bird species. Therefore, this study was aimed to evaluate the effect of Pb on several physiological parameters in house sparrows exposed to environmental Pb concentrations. In a first experiment, birds were exposed to Pb sub-lethal doses (from 1.3 to 14.0 µg of Pb/g animal/day) during 5 days, which resulted in a dose response increase of blood Pb levels and decrease of blood ALAD activity...
February 17, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29456407/analysis-of-hepatitis-b-virus-pres1-variability-and-prevalence-of-the-rs2296651-polymorphism-in-a-spanish-population
#20
Rosario Casillas, David Tabernero, Josep Gregori, Irene Belmonte, Maria Francesca Cortese, Carolina González, Mar Riveiro-Barciela, Rosa Maria López, Josep Quer, Rafael Esteban, Maria Buti, Francisco Rodríguez-Frías
AIM: To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. METHODS: Serum samples from 246 individuals were included and divided into 3 groups: patients with chronic HBV infection (CHB) ( n = 41, 73% Caucasians), patients with resolved HBV infection ( n = 100, 100% Caucasians) and an HBV-uninfected control group ( n = 105, 100% Caucasians)...
February 14, 2018: World Journal of Gastroenterology: WJG
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