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https://www.readbyqxmd.com/read/29656147/liver-fibrosis-direct-antifibrotic-agents-and-targeted-therapies
#1
REVIEW
Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim
Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of patients with chronic liver disease. Their prevention or reversal have become major endpoints in clinical trials with novel liver specific drugs. Remarkable progress has been made with therapies that efficiently address the cause of the underlying liver disease, as in chronic hepatitis B and C. Highly effective antiviral therapy can prevent progression or even induce reversal in the majority of patients, but such treatment remains elusive for the majority of liver patients with advanced alcoholic or nonalcoholic steatohepatitis, genetic or autoimmune liver diseases...
April 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29653132/sofosbuvir-inhibits-hepatitis-a-virus-replication-in-vitro-assessed-by-a-cell-based-fluorescent-reporter-system
#2
Wang Jiang, Fawad Muhammad, Pengjuan Ma, Xiyu Liu, Gang Long
Hepatitis A virus (HAV) infection remains a major cause of acute hepatitis worldwide and even leads to fulminant hepatitis. For screening antivirals against HAV in vitro, we develop a cell-based fluorescent reporter system named Huh-7.5.1-GA, in which HAV infection is visualized by green fluorescence protein (GFP) translocation from the cytosol into the nucleus. The reliability of Huh-7.5.1-GA for antiviral studies is validated by IFN-α, a known inhibitor of HAV replication, which impedes GFP translocation...
April 10, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29650849/-a-case-of-resected-reactive-lymphoid-hyperplasia-of-liver-suspected-of-hepatocellular-carcinoma
#3
Kei Nakamura, Akira Sougawa, Tomoyuki Nagata, Satoshi Mochizuki, Yuen Nakase, Shozo Kitai, Seishirou Inaba
A 64-year-old woman who had chronic type C viral hepatitis was referred with a liver tumor detected by magnetic resonance imaging(MRI). She had a history of rheumatoid arthritis which was treated by methotrexate. Ethoxybenzyl-MRI(EOBMRI) showed a low signal in the T1-weighted imaging, a high signal in the T2-weighted imaging and a low signal in the hepatobiliary phase. The tumor was 7 millimeters in diameter at S4, and exhibited enhancement in the arterial phase and wash out in the portal phase by contrast enhanced CT...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650438/hepatitis-e-virus-infection-mimicking-acute-graft-rejection-in-a-liver-transplant-recipient
#4
M Allaire, C Bazille, J Selves, E Salamé, M Altieri
INTRODUCTION: In liver transplant (LT) patients, hepatitis E virus (HEV) can lead to acute liver failure, chronic hepatitis and graft cirrhosis. Few data on graft rejection associated with HEV are available and are subject to discussion. CASE REPORT: Here we report the case of a 58-year-old male patient who underwent LT in July 2015 for cirrhosis due to NASH and chronic alcohol intake complicated by hepatocellular carcinoma. LT was performed with a deceased donor isogroup and a mismatch CMV (donor+ and recipient-)...
April 10, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29644537/drug-drug-interaction-profile-of-the-fixed-dose-combination-tablet-regimen-ledipasvir-sofosbuvir
#5
REVIEW
Polina German, Anita Mathias, Diana M Brainard, Brian P Kearney
Ledipasvir/sofosbuvir (Harvoni® ), a fixed-dose combination tablet of an NS5A inhibitor ledipasvir and an NS5B polymerase inhibitor sofosbuvir, is approved for the treatment of chronic hepatitis C virus infection. Ledipasvir/sofosbuvir exhibits a favorable drug-drug interaction profile and can be administered with various medications that may be used by hepatitis C virus-infected patients, including patients with comorbidities, such as co-infection with human immunodeficiency virus or immunosuppression following liver transplantation...
April 11, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29644094/insufficiency-of-dna-repair-enzyme-atm-promotes-naive-cd4-t-cell-loss-in-chronic-hepatitis-c-virus-infection
#6
Juan Zhao, Xindi Dang, Peixin Zhang, Lam Nhat Nguyen, Dechao Cao, Lin Wang, Xiaoyuan Wu, Zheng D Morrison, Ying Zhang, Zhansheng Jia, Qian Xie, Ling Wang, Shunbin Ning, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Yao
T cells have a crucial role in viral clearance and vaccine response; however, the mechanisms regulating their responses to viral infections or vaccinations remain elusive. In this study, we investigated T-cell homeostasis, apoptosis, DNA damage, and repair machineries in a large cohort of subjects with hepatitis C virus (HCV) infection. We found that naive CD4 T cells in chronically HCV-infected individuals (HCV T cells) were significantly reduced compared with age-matched healthy subjects. In addition, HCV T cells were prone to apoptosis and DNA damage, as evidenced by increased 8-oxoguanine expression and γH2AX/53BP1-formed DNA damage foci-hallmarks of DNA damage responses...
2018: Cell Discovery
https://www.readbyqxmd.com/read/29643780/intravenous-drug-use-associated-scopulariopsis-endophthalmitis-treated-with-systemic-and-intravitreal-voriconazole
#7
Joseph J Raevis, Neha Shaik, Joseph Tseng
Purpose: To report a case of intravenous (i.v.) heroin use-associated endogenous endophthalmitis caused by Scopulariopsis fungal species, and its response to intravitreal and oral voriconazole treatments. Patient: A 21-year-old-female with chronic hepatitis C and i.v. heroin use presented with subacute decreased vision to hand motion in her left eye. Results: Endogenous fungal endophthalmitis caused by Scopulariopsis was confirmed by vitreous biopsy...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29642827/-analysis-of-hepatitis-b-virus-hbv-pres1-pres2-and-s-gene-regions-from-patient-groups-infected-with-hbv-genotype-d
#8
Eylem Karataş, Selda Erensoy, Ulus Salih Akarca, Rüçhan Sertöz
Mutations in preS and S gene regions of hepatitis B virus genome may cause immune escape and diagnostic escape HBV mutants. The aim of this study was to determine preS1, preS2 and S gene regions of HBV from HBV infected patient groups by sequence analysis and contribute to the relevant literature. Nucleic acid sequence analysis of preS and S genes of HBV PCR products from 56 archived plasma samples sent to Ege University Faculty of Medicine Medical Microbiology Department Molecular Virology laboratory, for HBV tests were determined by chain termination reaction...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29629626/the-role-of-neutrophil-to-lymphocyte-ratio-for-the-assessment-of-liver-fibrosis-and-cirrhosis-a-systematic-review
#9
Ying Peng, Yan Li, Yonghong He, Qinglin Wei, Qiaoling Xie, Liangjun Zhang, Yiju Xia, Xueqian Zhou, Lu Zhang, Xinchan Feng, Kun Chen, Sheng Chen, Wensheng Chen, Qinglin Long, Jin Chai
Neutrophil to lymphocyte ratio (NLR) is widely used to assess inflammatory diseases. We performed a systematic review to explore the prognostic role of NLR for the assessment of liver fibrosis and cirrhosis. Areas covered: We searched the PubMed and EMBASE databases for the eligible papers which explored the association between NLR and liver fibrosis/cirrhosis or investigated the prognostic value of NLR in cirrhotic patients. Expert commentary: In accordance with assessment of liver fibrosis stage, we classified papers into four subgroups by etiology...
April 9, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29628768/outcomes-and-predictors-of-treatment-response-with-sofosbuvir-plus-daclatasvir-with-or-without-ribavirin-in-egyptian-patients-with-genotype-4-hepatitis-c-virus-infection
#10
Ossama A Ahmed, Mohamed A Elsebaey, Mohamed Hassan A Fouad, Heba Elashry, Ahmed I Elshafie, Ahmed A Elhadidy, Noha E Esheba, Mohammed H Elnaggar, Shaimaa Soliman, Sherief Abd-Elsalam
Background and aims: Treatment of hepatitis C virus (HCV) changed dramatically with the introduction of oral direct-acting antiviral drugs due to their high antiviral potency and safety profile. Sofosbuvir plus daclatasvir combination therapy was extensively investigated in HCV genotypes 1, 2, and 3, while published data regarding its real-life application in the treatment of genotype 4 is lacking. Therefore, we conducted this study to assess the outcomes and predictors of treatment response with sofosbuvir plus daclatasvir with or without ribavirin in Egyptian patients with genotype 4 hepatitis C virus infection...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29626296/real-world-efficacy-and-safety-of-ledipasvir-and-sofosbuvir-in-patients-with-hepatitis-c-virus-genotype-1-infection-a-nationwide-multicenter-study-by-the-japanese-red-cross-liver-study-group
#11
Keiji Tsuji, Masayuki Kurosaki, Jun Itakura, Nami Mori, Shintaro Takaki, Chitomi Hasebe, Takehiro Akahane, Kouji Joko, Hitoshi Yagisawa, Jirou Takezawa, Ryou Nakata, Atsunori Kusakabe, Yuji Kojima, Hiroyuki Kimura, Takashi Tamada, Haruhiko Kobashi, Akeri Mitsuda, Masahiko Kondou, Chikara Ogawa, Yasushi Uchida, Tetsuro Sohda, Ryouichi Narita, Namiki Izumi
BACKGROUND: We aimed to describe the real-world efficacy and safety of combination therapy with ledipasvir and sofosbuvir (LDV/SOF) for chronic hepatitis C virus (HCV) genotype 1 (GT1) infection. METHODS: This retrospective analysis of a prospective, nationwide, multicenter registry included GT1-infected patients treated with LDV/SOF for 12 weeks. We assessed the rate of sustained virological response at 12 weeks post-treatment (SVR12), incidence of adverse events, and serum markers of hepatocellular carcinoma (HCC)...
April 6, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29626003/probable-fidaxomicin-induced-pancytopenia
#12
Samantha Axtell, Aisha Shokoya, Christine Yocum
PURPOSE: A case of pancytopenia in a patient receiving treatment with fidaxomicin for Clostridium difficile infection (CDI) is described. SUMMARY: A 33-year-old Caucasian woman was admitted to the hospital with a chief complaint of loose stools occurring approximately 7 times a day; she also reported fever, nausea, diffuse abdominal pain, and fatigue. The patient had a history of recurrent CDI, recurrent urinary tract infections, nephrolithiasis, chronic hepatitis C, and endometriosis...
April 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29625837/hbsag-stimulates-nkg2d-receptor-expression-on-natural-killer-cells-and-inhibits-hepatitis-c-virus-replication
#13
Xiao-Xiao Wang, Xiao-Ben Pan, Jin-Chao Han, Xu Cong, Qian Jin, Xiang-Sha Kong, Lai Wei, Bo Feng
BACKGROUND: Higher hepatitis B surface antigen (HBsAg) facilitates hepatitis C virus (HCV) clearance in patients with hepatitis B virus (HBV)/HCV co-infection. We investigated the effect of exogenous HBsAg on the inhibition of HCV replication mediated by natural killer (NK) cells. METHODS: After isolated from peripheral blood of 42 chronic hepatitis B (CHB) patients and 16 healthy individuals, NK cells were co-cultured with HCV-infected Huh7 cells, respectively, with or without HBsAg...
March 26, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29624804/dialysis-facility-screening-and-testing-practices-in-the-era-of-improved-hepatitis-c-treatment
#14
Miranda S Moore, Angelica Bocour, Ann Winters
Patients receiving hemodialysis are at increased risk of hepatitis C virus (HCV) infection, and routine screening is recommended. Highly effective HCV treatments for dialysis patients are newly available and cure >90% of patients in 12 weeks. Dialysis facilities should screen individuals for HCV, confirm infections, and treat or link patients to care and treatment. The New York City (NYC) Department of Health and Mental Hygiene electronically receives all positive HCV antibody and all positive and negative HCV RNA tests for NYC residents...
April 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29624755/searching-for-unknown-transfusion-transmitted-hepatitis-viruses-a-bi-national-cohort-study-of-1-5-million-transfused-patients
#15
Gustaf Edgren, Henrik Hjalgrim, Klaus Rostgaard, Viktor Dahl, Kjell Titlestad, Christian Erikstrup, Agneta Wikman, Rut Norda, Ammar Majeed
BACKGROUND: Both hepatitis B and C viruses were transmitted through blood transfusion before implementation of donor screening. The existence of additional, yet unknown transfusion transmittable agents causing liver disease could have important public health implications. METHODS: Analyses were based on the Scandinavian Donations and Transfusions (SCANDAT2) database. Cox regression models were used to estimate the hazard ratio (HR) of developing chronic liver disease in recipients of blood from donors who later developed any chronic liver disease compared to recipients who received blood transfusion from healthy donors...
April 6, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29624693/accuracy-of-2d-shear-wave-elastography-in-the-diagnosis-of-liver-fibrosis-in-patients-with-chronic-hepatitis-c
#16
Tamami Abe, Hidekatsu Kuroda, Yudai Fujiwara, Yuichi Yoshida, Akio Miyasaka, Naohisa Kamiyama, Yasuhiro Takikawa
PURPOSE: This prospective study was conducted to assess the diagnostic accuracy of two-dimensional shear wave elastography (2D SWE) in the diagnosis of liver fibrosis in patients with chronic liver disease and hepatitis C virus (HCV) compared with the serum liver fibrosis biomarkers using the results of liver biopsy as the reference standard. METHODS: We analyzed 233 consecutive HCV patients. On the same day, 2D SWE m, biochemical tests, and liver biopsy were performed...
April 6, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29622968/atherosclerosis-in-chronic-hepatitis-c-virus-patients-with-and-without-liver-cirrhosis
#17
Ashraf Abd El-Khalik Barakat, Fatma Mohammad Nasr, Amna Ahmed Metwaly, Sherif Morsy, Mervat Eldamarawy
Background: Chronic Hepatitis C virus (HCV) infection and liver cirrhosis may be associated with atherosclerosis and coronary artery disease (CAD). There are two phases to atherosclerosis, Subclinical and Clinical. Assessment of atherosclerosis may be started at its Subclinical phase by the evaluation of Epicardial Fat Thickness (EpFT) and Carotid Intima Thickness (CIMT). Aim of the study: The aim of the study was to evaluate Clinical and Subclinical atherosclerosis in chronic HCV patients with and without liver cirrhosis by evaluating CIMT and EpFT and correlating the results with Child-Pugh functional scoring of cirrhosis as well as with ultrasound and laboratory parameters that define the severity of liver disease...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29622385/necrolytic-acral-erythema-leading-to-diagnosis-of-chronic-hepatitis-c
#18
Garima Dabas, Sindhuja Tekumalla, Sanjeev Handa
No abstract text is available yet for this article.
March 12, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29621544/prevalence-of-ns5a-resistance-associated-variants-in-ns5a-inhibitor-treatment-failures-and-an-effective-treatment-for-ns5a-p32-deleted-hepatitis-c-virus-in-humanized-mice
#19
Yuji Teraoka, Takuro Uchida, Michio Imamura, Mitsutaka Osawa, Masataka Tsuge, Hiromi Abe-Chayama, C Nelson Hayes, Grace Naswa Makokha, Hiroshi Aikata, Daiki Miki, Hidenori Ochi, Yuji Ishida, Chise Tateno, Kazuaki Chayama
Patients with chronic hepatitis C virus (HCV) infection who have failed to respond to direct-acting antiviral (DAA) treatment often acquire drug resistance-associated variants (RAVs). The NS5A-P32 deletion (P32del) RAV confers potent resistance to NS5A inhibitors; therefore, patients who acquire this deletion are likely to fail to respond to DAA re-treatment. We investigated the prevalence of N55A-P32del in patients who failed to respond to prior NS5A inhibitor treatment using direct sequencing and analyzed the efficacy of DAA combination treatment in the presence of NS5A-P32del RAVs using human hepatocyte transplanted mice...
April 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29620815/a-descriptive-study-of-patients-receiving-foundational-financial-assistance-through-local-specialty-pharmacies
#20
Julia Zhu, Randall Odebralski, Safia Boghani, Clorinda Walley, Frank Koen, Chad Conley, Heather S Kirkham
OBJECTIVES: To describe the population of patients who received financial assistance from the Good Days Foundation (GDF) as facilitated by Walgreens local specialty pharmacies (LSPs). STUDY DESIGN: This was a retrospective descriptive study. METHODS: This study used a joint foundational and pharmacy claim database between January 1, 2014, and December 31, 2016. RESULTS: Among 1572 eligible patients who received GDF financial assistance as facilitated by Walgreens LSPs, 1524 had disease state information and 14 of these patients receveived financial assistance for 2 disease states (patient count denominator, 1538)...
March 2018: American Journal of Managed Care
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