Halis Şımşek, Aslı Pinar, Akif Altinbaş, Alparslan Alp, Yasemin H Balaban, Yahya Büyükaşik, Osman Özcebe, Gülşen Hasçelık, Gökhan Gedıkoğlu, Gonca Tatar
BACKGROUND/AIMS: Alpha-1 antitrypsin deficiency causes accumulation of mutant alpha-1 antitrypsin molecules in hepatocytes, and is attributed to severe liver injury even in heterozygous state. However, there is a question as to whether alpha-1 antitrypsin deficiency is only a cause of liver injury or has a worsening effect on the underlying liver disease. We aimed to determine the role of alpha-1 antitrypsin deficiency in the ongoing chronic hepatitic process. MATERIALS AND METHODS: Fifty-four patients with the diagnosis of chronic hepatitis by liver biopsy (36 chronic hepatitis B virus, 8 chronic hepatitis C virus, 7 non-alcoholic steatohepatitis, 2 primary biliary cirrhosis, and 1 autoimmune hepatitis) and 51 age- and sex-matched control subjects chosen from among healthy blood donors were included in the study...
2012: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology