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https://www.readbyqxmd.com/read/28422884/posterior-reversible-encephalopathy-syndrome-in-a-postpartum-hemorrhagic-woman-without-hypertension-a-case-report
#1
Chon-Fu Lio, Ying-Hua Lee, Hung-Yen Chan, Chang-Ching Yu, Nan-Jing Peng, Hung-Pin Chan
RATIONALE: Posterior reversible encephalopathy syndrome (PRES), which diagnosis is based on clinical symptoms and radiological features, is a neurotoxic disease characterized by a set of clinical manifestations, such as seizure, headache, visual, and/or consciousness disturbance. It is the first case of PRES followed by postpartum hemorrhage (PPH) without underlying disease. PATIENT CONCERNS: A 37-year-old healthy woman had PPH after caesarean section. Six days after delivery, headache occurred suddenly, followed by episodes of clonus seizure...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28417553/calcineurin-inhibitor-free-strategies-for-prophylaxis-and-treatment-of-gvhd-in-children-with-posterior-reversible-encephalopathy-syndrome-after-stem-cell-transplantation
#2
Vered Shkalim-Zemer, Osnat Konen, Yoel Levinsky, Orli Michaeli, Anat Yahel, Aviva Krauss, Isaac Yaniv, Jerry Stein
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a distinct clinico-radiologic entity that can occur following allogeneic hematopoietic stem cell transplantation, often in the context of treatment with calcineurin inhibitors (CNIs). PROCEDURE: We describe the results of CNI-free management of 14 children with PRES and review the clinical and radiologic manifestations of their presentation. RESULTS: Discontinuation of CNIs usually resulted in remission of PRES, but patients with established graft versus host disease (GVHD) at the time when treatment was changed often experienced progressive GVHD despite administration of immune suppressive and modulating treatments...
April 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28416534/pazopanib-associated-posterior-reversible-encephalopathy-syndrome-with-intracerebral-haemorrhage
#3
Cameron Miller-Patterson, Corey R Fehnel
Pazopanib is a tyrosine kinase receptor antagonist used for renal cell carcinoma and soft tissue sarcoma that inhibits tumour growth and angiogenesis. A common side effect of pazopanib is hypertension. We report a case of a 69-year-old woman with clear cell renal cell carcinoma who developed a large right occipital intracerebral haemorrhage 3 weeks after initiating pazopanib. Although this was initially suspected to be a haemorrhagic metastasis, MRI revealed bi-occipital oedema, supporting a diagnosis of posterior reversible encephalopathy syndrome (PRES)...
April 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28416081/reversible-cerebral-vasoconstriction-syndrome-combined-with-posterior-reversible-encephalopathy-syndrome-after-heart-transplantation
#4
Seung Pil Ban, Gyojun Hwang, Chang Hyeun Kim, O-Ki Kwon
Reversible cerebral vasoconstriction syndrome (RCVS) combined with posterior reversible encephalopathy syndrome (PRES) is a rare complication in patients treated with immunosuppressants. A 52-year-old male patient presented with seizures after heart transplantation. The patient was suspected of having PRES on brain images. Despite the strict blood pressure control, the patient presented with altered mentality and the brain images showed a newly developed large acute infarction. Digital subtraction angiography (DSA) revealed the classic "sausage on a string" appearance of the cerebral arteries - potential feature of RCVS...
April 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28414318/initial-sites-of-hepadnavirus-integration-into-host-genome-in-human-hepatocytes-and-in-the-woodchuck-model-of-hepatitis-b-associated-hepatocellular-carcinoma
#5
R Chauhan, N D Churchill, P M Mulrooney-Cousins, T I Michalak
Hepatitis B virus (HBV) and the closely related woodchuck hepatitis virus (WHV) are potent carcinogens that trigger development of primary hepatocellular carcinoma (HCC). The initial sites of hepadnavirus-host genome integration, their diversity and kinetics of formation can be central to virus persistence and the initiation and progression of HCC. To recognize the nature of the very early virus-host interactions, we explored de novo infection of human hepatocyte-like HepaRG cells with authentic HBV and naive woodchucks with WHV...
April 17, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28404583/acute-hypoxia-activates-neuroendocrine-but-not-pre-sympathetic-neurons-in-the-paraventricular-nucleus-of-the-hypothalamus-differential-role-of-nitric-oxide
#6
K Max Coldren, De-Pei Li, David D Kline, Eileen M Hasser, Cheryl M Heesch
Hypoxia results in decreased arterial PO2, arterial chemoreflex activation, and compensatory increases in breathing, sympathetic outflow, and neuroendocrine secretions, including increased secretion of vasopressin (AVP), corticotropin releasing hormone (CRH), adrenocorticotropin hormone (ACTH), and corticosterone. In addition to a brainstem pathway including the nucleus tractus solitarius (nTS) and the rostral ventrolateral medulla (RVLM), medullary pathways to the paraventricular nucleus of the hypothalamus (PVN) contribute to chemoreflex responses...
April 12, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28381411/dual-functionality-of-cis-regulatory-elements-as-developmental-enhancers-and-polycomb-response-elements
#7
Jelena Erceg, Tibor Pakozdi, Raquel Marco-Ferreres, Yad Ghavi-Helm, Charles Girardot, Adrian P Bracken, Eileen E M Furlong
Developmental gene expression is tightly regulated through enhancer elements, which initiate dynamic spatio-temporal expression, and Polycomb response elements (PREs), which maintain stable gene silencing. These two cis-regulatory functions are thought to operate through distinct dedicated elements. By examining the occupancy of the Drosophila pleiohomeotic repressive complex (PhoRC) during embryogenesis, we revealed extensive co-occupancy at developmental enhancers. Using an established in vivo assay for PRE activity, we demonstrated that a subset of characterized developmental enhancers can function as PREs, silencing transcription in a Polycomb-dependent manner...
March 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28376105/video-urodynamic-characteristics-of-non-neurogenic-idiopathic-underactive-bladder-in-men-a-comparison-of-men-with-normal-tracing-and-bladder-outlet-obstruction
#8
Yuan-Hong Jiang, Hann-Chorng Kuo
OBJECTIVE: Underactive bladder is frequently encountered in elderly patients. It may result from detrusor underactivity (DU) or low detrusor contractility due to a urethral sphincter inhibitory effect. This study analyzed the video-urodynamic study (VUDS) characteristics of patients with underactive bladder in a large cohort of men with lower urinary tract symptoms (LUTS). METHODS: Male patients with LUTS who had failed the initial treatment were consecutively enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28376083/bovine-and-murine-models-highlight-novel-roles-for-slc25a46-in-mitochondrial-dynamics-and-metabolism-with-implications-for-human-and-animal-health
#9
Amandine Duchesne, Anne Vaiman, Johan Castille, Christian Beauvallet, Pauline Gaignard, Sandrine Floriot, Sabrina Rodriguez, Marthe Vilotte, Laurent Boulanger, Bruno Passet, Olivier Albaric, François Guillaume, Abdelhak Boukadiri, Laurence Richard, Maud Bertaud, Edouard Timsit, Raphaël Guatteo, Florence Jaffrézic, Pierre Calvel, Louise Helary, Rachid Mahla, Diane Esquerré, Christine Péchoux, Sophie Liuu, Jean-Michel Vallat, Didier Boichard, Abdelhamid Slama, Jean-Luc Vilotte
Neuropathies are neurodegenerative diseases affecting humans and other mammals. Many genetic causes have been identified so far, including mutations of genes encoding proteins involved in mitochondrial dynamics. Recently, the "Turning calves syndrome", a novel sensorimotor polyneuropathy was described in the French Rouge-des-Prés cattle breed. In the present study, we determined that this hereditary disease resulted from a single nucleotide substitution in SLC25A46, a gene encoding a protein of the mitochondrial carrier family...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28374256/analysis-of-magnetic-resonance-imaging-findings-of-children-with-neurologic-complications-after-liver-transplantation
#10
Mehmet Öztürk, İsmail Akdulum, Nurullah Dağ, Ahmet Sığırcı, Serdal Güngör, Sezai Yılmaz
OBJECTIVE: To analyze the magnetic resonance imaging findings in children diagnosed with neurologic complications after liver transplantation (LT). MATERIALS AND METHODS: A total of 39 patients diagnosed with neurologic complications following LT between 2010 and 2016. Neuroradiologic imaging was performed using cranial magnetic resonance imaging (MRI). Descriptive statistics regarding age, gender, type of complication, diagnostic and therapeutic modalities were calculated and presented as number and percentage...
April 3, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28373149/immune-system-activation-in-the-pathogenesis-of-posterior-reversible-encephalopathy-syndrome
#11
REVIEW
Zheng Chen, Gui-Quan Shen, Alexander Lerner, Bo Gao
Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological syndrome characterized by a variable combination of headaches, seizures, altered mental status, visual impairment, focal neurological signs and symmetric vasogenic edema in bilateral posterior cerebral circulation territory. The pathogenesis of PRES is still controversial. Most of the clinical conditions associated with PRES involve a systemic toxicity response in the entire organism with activation of the cells of the immune system and cytokines...
March 31, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28373061/sequence-analysis-and-functional-characterization-of-full-length-hepatitis-b-virus-genomes-from-korean-cirrhotic-patients-with-or-without-liver-cancer
#12
Huailiang Zhou, Dina Gewaily, Sang Hoon Ahn, Carina Preskill, Yongxiang Wang, Li Zong, Jing Zhang, Kwang-Hyub Han, Jack Wands, Jisu Li, Shuping Tong
This study aimed to identify and characterize mutations in the hepatitis B virus (HBV) genome associated with advanced liver diseases. The 3.2-kb HBV genome of the C2 subgenotype was amplified from sera of 18 cirrhotic Korean patients with (10) or without (8) hepatocellular carcinoma (HCC), and two clones per patient were characterized by transient transfection experiments in human hepatoma cells. While A1762T/G1764A core promoter mutations were highly prevalent in both groups, the G1896A precore mutation to abolish hepatitis B e antigen (HBeAg) expression was more common in HCC clones (55% vs...
March 31, 2017: Virus Research
https://www.readbyqxmd.com/read/28372869/a-pediatric-case-of-reversible-cerebral-vasoconstriction-syndrome-with-similar-radiographic%C3%A2-findings-to-posterior-reversible-encephalopathy-syndrome
#13
Tomoya Kamide, Taishi Tsutsui, Kouichi Misaki, Hiroki Sano, Masanao Mohri, Naoyuki Uchiyama, Mitsutoshi Nakada
BACKGROUND: Reversible cerebral vasoconstriction syndrome occurs predominantly in middle-aged women. Only nine pediatric cases of this syndrome have been reported. PATIENT DESCRIPTION: We present a ten-year-old boy with reversible cerebral vasoconstriction syndrome with radiographic findings similar to those of posterior reversible encephalopathy syndrome (PRES). He presented with a thunderclap headache without a neurological deficit. Brain magnetic resonance angiography (MRA) revealed multifocal narrowing of the cerebral arteries, whereas magnetic resonance imaging (MRI) with diffusion-weighted imaging and fluid-attenuated inversion recovery demonstrated hyperintense lesions in the occipital lobes and the left cerebellum...
February 20, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28362470/impact-of-green-tea-extract-addition-on-oxidative-changes-in-the-lipid-fraction-of-pastry-products
#14
Anna Żbikowska, Małgorzata Kowalska, Jarosława Rutkowska, Mariola Kozłowska, Sylwia Onacik-Gür
BACKGROUND: Alongside flour, fat is the key ingredient of sponge cakes, including those with long shelf lives. It is an unstable food component, whose quality and nutritional safety depend on the composition and pres- ence of oxidation products. Consumption of fat oxidation products adversely affects the human body and contributes to the incidence of a number of medical conditions. Qualitative changes in fats extracted from thermostat sponge cakes with and without antioxidant additions were determined in this study...
January 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28361069/posterior-reversible-encephalopathy-syndrome-associated-with-left-horizontal-gaze-palsy
#15
Amer Hawatmeh, Sarah Studyvin, Moh'd Al-Halawani, Sawsan Amireh, Mohammad Thawabi
Posterior reversible encephalopathy syndrome (PRES) is characterized by rapid onset of symptoms including headache, seizures, altered consciousness, and visual disturbance, as well as radiologic findings of focal reversible vasogenic edema. Multiple visual disturbances have been described in PRES, such as hemianopia, visual neglect, auras, visual hallucinations, and cortical blindness. However, horizontal gaze palsy has not been previously reported. We report a 72-year-old female who presented with blurred vision, severe headache, lethargy, and later developed seizures...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28357173/status-epilepticus-and-blindness-in-a-patient-with-carfilzomib-associated-posterior-reversible-encephalopathy-syndrome
#16
Salam Kadhem, Rawaa Ebrahem, Scott Cooper, Emily Manlove, Ricky Lee
Posterior reversible encephalopathy syndrome (PRES) is a neurological condition characterized by headaches, visual disturbances, and seizures. A magnetic resonance imaging (MRI) scan of an affected brain typically shows symmetrical white matter edema in the posterior cerebral hemispheres. The onset of PRES can constitute a medical emergency, especially when accompanied by status epilepticus. If promptly recognized and treated, the clinical syndrome and associated radiological findings are usually resolved in a matter of weeks or months...
February 19, 2017: Curēus
https://www.readbyqxmd.com/read/28349115/posterior-reversible-encephalopathy-syndrome-pres-associated-with-ovarian-cancer-and-voltage-gated-potassium-channel-antibodies-a-case-report
#17
Laura K Hadad, Caroline C Billingsley
•We report a case of PRES in conjunction with high grade serous ovarian carcinoma•There is a documented association between chemotherapy agents and PRES•Paraneoplastic panel was positive for voltage-gated potassium channel antibodies•Paraneoplastic workup may be justified in cases with high suspicion of PRES.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28346720/videourodynamic-analysis-of-the-urethral-sphincter-overactivity-and-the-poor-relaxing-pelvic-floor-muscles-in-women-with-voiding-dysfunction
#18
Chung-Hsin Peng, Sheng-Fu Chen, Hann-Chorng Kuo
AIMS: Voiding dysfunction due to dysfunctional voiding (DV) and poor relaxation of the external sphincter (PRES) are commonly found among adult women with lower urinary tract symptoms (LUTS) during videourodynamic study (VUDS). This study analyzed the VUDS characteristics of DV and PRES in female voiding dysfunction. METHODS: This retrospective study involved 1914 women aged >18 years with refractory LUTS. The medical records and the VUDS parameters were reviewed...
March 27, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28341199/quantitative-magnetic-resonance-diffusion-weighted-imaging-evaluation-of-the-supratentorial-brain-regions-in-patients-diagnosed-with-brainstem-variant-of-posterior-reversible-encephalopathy-syndrome-a-preliminary-study
#19
Tai-Yuan Chen, Te-Chang Wu, Ching-Chung Ko, I-Jung Feng, Yu-Kun Tsui, Chien-Jen Lin, Jeon-Hor Chen, Ching-Po Lin
BACKGROUND AND PURPOSE: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic entity with several causes, characterized by rapid onset of symptoms and typical neuroimaging features, which usually resolve if promptly recognized and treated. Brainstem variant of PRES presents with vasogenic edema in brainstem regions on magnetic resonance (MR) images and there is sparing of the supratentorial regions. Because PRES is usually caused by a hypertensive crisis, which would likely have a systemic effect and global manifestations on the brain tissue, we thus proposed that some microscopic abnormalities of the supratentorial regions could be detected with diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) analysis in brainstem variant of PRES and hypothesized that "normal-looking" supratentorial regions will increase water diffusion...
March 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28338570/a-case-of-all-developing-posterior-reversible-encephalopathy-secondary-to-hyponatremia
#20
Nilgun Eroglu, Aysenur Bahadir, Erol Erduran
Posterior reversible encephalopathy syndrome (PRES), may be due to different causes. It may develop secondary to hypertension, renal decompensation, electrolyte imbalance, and chemotherapeutic drugs. We describe a case of acute lymphoblastic leukemia in which PRES developed secondary to hyponatremia despite being normotensive during receipt of chemotherapy. Magnetic resonance imaging findings were suggestive of PRES. Partial diffusion restriction was observed in lesions in the bilateral occipitoparietal regions and the cerebellum...
March 23, 2017: Journal of Pediatric Hematology/oncology
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