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https://www.readbyqxmd.com/read/29022863/next-generation-sequencing-revealed-divergence-in-deletions-of-the-pres-region-in-the-hbv-genome-between-different-hbv-related-liver-diseases
#1
Jian'an Jia, Xiaotao Liang, Shipeng Chen, Hui Wang, Huiming Li, Meng Fang, Xin Bai, Ziyi Wang, Mengmeng Wang, Shanfeng Zhu, Fengzhu Sun, Chunfang Gao
In order to investigate if deletion patterns of the preS region can predict liver disease advancement, the preS region of the hepatitis B virus (HBV) genome in 45 chronic hepatitis B (CHB) and 94 HBV-related hepatocellular carcinoma (HCC) patients was sequenced by next-generation sequencing (NGS) and the percentages of nucleotide deletion in the preS region were analysed. Hierarchical clustering and heatmaps based on deletion percentages of preS revealed different deletion patterns between CHB and HCC patients...
October 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29018383/study-protocol-for-the-preschooler-regulation-of-emotional-stress-pres-procedure
#2
Livio Provenzi, Rafaela G M Cassiano, Giunia Scotto di Minico, Maria B M Linhares, Rosario Montirosso
Background: Emotional stress regulation (ESR) rapidly develops during the first months of age and includes different behavioral strategies which largely contribute to children's behavioral and emotional adjustment later in life. The assessment of ESR during the first years of life is critical to identify preschool children who are at developmental risk. Although ESR is generally included in larger temperament batteries [e.g., the Laboratory Temperament Assessment Battery (Lab-TAB)], there is no standardized observational procedure to specifically assess and measure ESR in preschool aged children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28991655/apparent-diffusion-coefficient-reduction-might-be-a-predictor-of-poor-outcome-in-patients-with-posterior-reversible-encephalopathy-syndrome
#3
Itaru Ninomiya, Masato Kanazawa, Yasuhisa Akaiwa, Takayoshi Shimohata, Kouichirou Okamoto, Osamu Onodera, Masatoyo Nishizawa
It is thought that posterior reversible encephalopathy syndrome (PRES) is both clinically and radiologically reversible. However, its reversible nature has been challenged based on reports of permanent neurological impairments. The factors that predict the development of irreversible neurological impairment are still unclear. In the present study, we investigated clinical manifestations, laboratory findings, and neuroradiological images to identify predictors of functional outcomes in PRES. We investigated 23 PRES patients...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28984140/spinal-cord-involvement-in-two-children-with-posterior-reversible-encephalopathy-syndrome
#4
Maurizio Lucchesi, Mario Mascalchi, Federico Mussa, Claudio Favre, Lorenzo Genitori, Iacopo Sardi
Spinal cord involvement (SCI) is a rare feature of posterior reversible encephalopathy syndrome (PRES), especially in children. SCI is generally symptomatic, and may have a different outcome compared with encephalic localization of PRES. We reported about two cases of SCI in pediatric patients with PRES, after multimodal anticancer therapies, including radiotherapy, chemotherapy and targeted agents.
October 6, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28978604/oxaliplatin-induced-posterior-reversible-encephalopathy-syndrome-pres
#5
Taimoor Khalid Janjua, Muhammad Hassan, Hira Khan Afridi, Naila Anjum Zahid
Posterior reversible encephalopathy syndrome (PRES), first introduced in 1996, is a neurotoxic state characterised by seizures, headache, vision change, paresis, nausea and altered mental status. Risk factors include hypertension, eclampsia/pre-eclampsia, infection/sepsis and cancer chemotherapy. Although exposure to toxic agents is a common occurrence in patients who develop PRES, oxaliplatin has rarely been associated with it, with only 10 cases reported worldwide. We present the case of an oxaliplatin-induced PRES in a 23-year-old male patient who was started on oxaliplatin/capecitabine as adjuvant chemotherapy for anal canal adenocarcinoma...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28978582/posterior-reversible-encephalopathy-syndrome-in-a-postpartum-woman-with-acute-lymphoblastic-leukaemia-after-intrathecal-methotrexate
#6
Craig Mescher, Arne Slungaard
Posterior reversible encephalopathy syndrome (PRES) is the most common neurological complication occurring in children undergoing induction chemotherapy for acute lymphoblastic leukaemia (ALL) but is increasingly recognised to occur in adults as well. Here, we report a woman who presented with B-cell ALL (B-ALL) at the time of delivery and developed PRES 1 day after receiving intrathecal (IT) methotrexate (MTX) that rapidly resolved. She subsequently received IT MTX without recurrence of neurological symptoms...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28974999/malignant-posterior-reversible-encephalopathy-syndrome-an-exacting-challenge-for-neurocritical-care-physicians
#7
Shahvaiz Magsi, Atif Zafar
We report a case of malignant posterior reversible encephalopathy syndrome (PRES) in a 62-year-old Caucasian female with a complex medical history and comorbidities admitted for bowel resection and lysis of iatrogenic bowel adhesions and enterocutaneous fistulas. Postoperatively, the patient developed sudden bilateral visual loss with no other neurologic deficits. Computed tomography scan showed very severe PRES-like changes, confirmed on magnetic resonance imaging (MRI). Systolic blood pressure remained around 170 mm HG...
October 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28973505/posterior-reversible-encephalopathic-syndrome-in-the-setting-of-induced-elevated-mean-arterial-pressure-in-patients-with-spinal-cord-injury
#8
Alexander C Whiting, Manuel P Fanarjian, Randall J Hlubek, Jakub Godzik, U Kumar Kakarla, Nicholas Theodore
BACKGROUND AND IMPORTANCE: Acute spinal cord injury (SCI) is managed by avoiding hypotension and elevating mean arterial pressure (MAP) to attain optimal perfusion of the spinal cord. Few studies have been published regarding complications related to this treatment paradigm. CLINICAL PRESENTATION: Three patients with SCI developed posterior reversible encephalopathic syndrome (PRES) during treatment with intravenous fluids and vasopressors administered to maintain elevated MAPs...
July 22, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28961992/capturing-environmental-plant-memories-in-dna-with-a-little-help-from-chromatin
#9
Diana Mihaela Buzas
Plants are eukaryotes living mostly immotile in harsh environments. On occasion, it is beneficial for their survival to maintain a transcriptional response to an environmental stress longer than the stress lasts (transcriptional memory) and even to reiterate such a response more quickly or more strongly when the same stress is re-encountered (priming memory). In eukaryotes, transcription takes place in the context of chromatin, the packaging material of DNA. Chromatin regulation is often invoked when it comes to environmental transcriptional and priming memory in plants, but rarely chromatin-based regulation can be accurately assigned to a given aspect of transcription in vivo...
August 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28939601/a-lytic-providencia-rettgeri-virus-of-potential-therapeutic-value-is-a-deep-branching-member-of-the-t5virus-genus
#10
Hugo Oliveira, Graça Pinto, Hanne Hendrix, Jean-Paul Noben, Jan Gawor, Andrew M Kropinski, Małgorzata Łobocka, Rob Lavigne, Joana Azeredo
Providencia rettgeri is emerging as a new opportunistic pathogen with high antibiotic resistance. The need to find alternative methods to control antibiotic resistant bacteria and the recent advances in phage therapy motivates the search of new phages able to infect Providencia spp.. This study describes the isolation and characterization of an obligatory lytic phage vB_PreS_PR1 (PR1) with therapeutic potential against drug-resistant P. rettgeri PR1 is a siphovirus. Its virion DNA size (118,537 bp), transcriptional organization, terminal repeats (10,461 bp) and nicks in the 3' -5' strand are similar to those of phage T5...
September 22, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28939016/pediatric-posterior-reversible-encephalopathy-syndrome-pres-with-spinal-cord-involvement-due-to-pheochromocytoma
#11
Daniel Freedman, Abena Koram, Natalie Gillson, Shawn C Aylward
No abstract text is available yet for this article.
July 12, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28936822/-posterior-reversible-encephalopathy-syndrome-triggerred-by-alcohol-withdrawal
#12
Tuğçe Mengi, Yaprak Seçil, Aysel Çoban, Yeşim Beckmann
INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity characterized by headache, altered mental status, epileptic seizures, visual disturbances and typically transient changes in posterior cerebral circulation areas. In this article, we present a case of alcohol withdrawal accompanied by PRES. CASE PRESENTATION: A 53-year-old male patient presented to the emergency department with visual hallucinations and meaningless speech...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28935244/contribution-of-hepatitis-b-c-virus-to-liver-cancer-in-china-north-areas-experience-from-chinese-national-cancer-center
#13
Minjie Wang, Yuting Wang, Xiaoshuang Feng, Ruijun Wang, Yanmei Wang, Hongmei Zeng, Jun Qi, Hong Zhao, Ni Li, Jianqiang Cai, Chunfeng Qu
AIM: To understand the impact of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) on primary liver cancer (PLC) in China north areas. METHODS: A total of 2172 histologically confirmed PLC patients in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences during January 1, 2003 and December 31, 2014 were enrolled. In some HCC cases we sequenced HBV PreS-S gene, C/E1 and NS5B fragment of HCV, and analyzed their genotypes. RESULTS: Among histologically confirmed 2172 PLC cases, 1823 (83...
September 18, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28911995/ocular-dysfunctions-presenting-in-tacrolimus-induced-posterior-reversible-encephalopathy-syndrome-a-case-presentation
#14
Cora Brown, Alexander J Feng, Ernesto Cruz
The constellation of ocular symptoms known as Balint syndrome is a rare disorder seen in bilateral parieto-occipital lesions and is most frequently due to arterial occlusive disease or acute hypertension. Here we present the case of a patient with tacrolimus-induced posterior reversible encephalopathy syndrome (PRES) who presented with optic ataxia, simultanagnosia, and ocular apraxia. These ocular findings, consistent with Balint syndrome, are rarely the initial presentation of PRES. This case highlights the importance of early recognition of this unusual phenomenon, as well as the importance of an individualized rehabilitation plan to maximize functional independence in these patients...
September 12, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28910681/the-imaging-spectrum-of-posterior-reversible-encephalopathy-syndrome-a-pictorial-review
#15
REVIEW
Emily Brady, Neal S Parikh, Babak B Navi, Ajay Gupta, Andrew D Schweitzer
Posterior reversible encephalopathy syndrome (PRES) is characterized by the acute onset of neurologic symptoms (headache, altered mental status, visual changes, seizures) with accompanying vasogenic edema on brain imaging. Risk factors for PRES include infection, uremia, malignancy, autoimmune disorders, the peripartum state and hypertension. PRES is classically described as being posterior (i.e. parieto-occipital) but radiologic variants are increasingly recognized. This pictorial review demonstrates the heterogeneity of the different radiologic presentations of PRES in reference to lesion distribution, hemorrhage, diffusion restriction, contrast enhancement, and other associated findings...
August 30, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28900616/implementing-precision-antimicrobial-therapy-for-the-treatment-of-bovine-respiratory-disease-current-limitations-and-perspectives
#16
Guillaume Lhermie, Pierre-Louis Toutain, Farid El Garch, Alain Bousquet-Mélou, Sébastien Assié
The therapeutic efficacy of an early treatment protocol with an infection-stage adjusted fluoroquinolone regimen was evaluated in a field study on young bulls (YBs) presenting signs of bovine respiratory disease (BRD). A total of 195 YB (Charolais, Limousin, and Rouge-des-Prés breeds) from 6 farms implementing or not prophylactic antimicrobial treatments (PROPHY or absence) were randomly assigned to 1 of 2 experiment groups based on time of detection of BRD and first-line marbofloxacin regimen, early adjusted dose [Early 2 (E2)] or late standard dose [Late 10 (L10)]...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28893891/health-leaders-must-share-the-reins-of-reform-outgoing-cma-pres
#17
Lauren Vogel
No abstract text is available yet for this article.
September 11, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28893888/focus-on-patients-the-rest-will-follow-says-new-cma-pres
#18
Lauren Vogel
No abstract text is available yet for this article.
September 11, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28887083/pres-leading-to-the-diagnosis-of-mcardle-disease
#19
Jennifer M Martinez-Thompson, Sean J Pittock, Margherita Milone
A 35year-old male developed myalgias after moving furniture and was hospitalized with acute renal failure and rhabdomyolysis requiring hemodialysis. He then had several generalized tonic-clonic seizures. Brain MRI showed findings of posterior reversible encephalopathy syndrome (PRES). Interval history revealed easy fatigability and exercise-induced myalgias in childhood but no preceding history of urine discoloration. Quadriceps biopsy showed absent muscle myophosphorylase reactivity consistent with the diagnosis of McArdle disease...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28874438/future-of-health-system-hinges-on-collaboration-outgoing-cma-pres
#20
Lauren Vogel
No abstract text is available yet for this article.
September 5, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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