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https://www.readbyqxmd.com/read/29660996/annals-express-a-case-of-hereditary-coproporphyria-with-posterior-reversible-encephalopathy-and-novel-cpox-gene-mutation-c-863t-g-p-leu288trp
#1
Deborah Lambie, Christopher M Florkowski, Chris Sies, Anthony Raizis, Wai-Kwan Siu, Cindy Towns
A 21 year old female had recurrent presentations to the Emergency Department (ED) with myalgia, vomiting, abdominal pain and subsequently developed generalized seizures. She was volume depleted with a plasma sodium of 125 mmol/L (reference interval 135-145) and she had fluctuating hypertension. Acute porphyria was suspected and confirmed with raised urine porphobilinogen (PBG)/creatinine ratio of 12·4 umol/mmol (reference interval < 1·5) and she was treated with intravenous haem arginate. Urinary porphyrin/creatinine ratio was 673 nmol/mmol, (reference interval <35) and faecal porphyrins 2430 umol/kg dry weight (reference interval <200) were markedly elevated, with raised faecal CIII:CI ratio, consistent with acute coproporphyria...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29651701/the-pres-deletion-of-hepatitis-b-virus-hbv-is-associated-with-liver-fibrosis-progression-in-patients-with-chronic-hbv-infection
#2
Fan Li, Xiaodong Li, Tao Yan, Yan Liu, Yongqian Cheng, Zhihui Xu, Qing Shao, Hao Liao, Pengyu Huang, Jin Li, Guo-Feng Chen, Dongping Xu
BACKGROUND AND AIMS: Limited data are available regarding the association of hepatitis B virus (HBV) mutations with liver fibrosis in HBV infection. The study aimed to clarify whether HBV preS deletion mutation is associated with liver fibrosis progression. METHODS: A total of 469 patients were enrolled, including 324 with chronic hepatitis B (CHB), 28 with HBV-related compensated liver cirrhosis (LC), and 117 with HBV-related decompensated LC. All CHB and compensated LC patients received liver biopsy...
April 12, 2018: Hepatology International
https://www.readbyqxmd.com/read/29648820/facile-c-h-bond-metathesis-mediated-by-a-stannylene
#3
Ting Yi Lai, James C Fettinger, Philip P Power
The diarylstannylene, :Sn(AriPr4)2 (AriPr4 = C6H3-2,6-(C6H3-2,6-iPr 2)2), undergoes C-H metathesis with toluene, m-xylene or mesitylene in solutions of these solvents at 80 °C. The products, [AriPr4Sn(CH2Ar)]2 (Aryl= C6H5 (1a), C6H4-3-Me (1b), C6H3-3,5-Me2(1c)) were characterized via 1H , 13C and 119Sn NMR, UV-vis and IR spectroscopy, and by X-ray crystallography for 1a and 1b. A stoichiometric amount of the arene, AriPr4H, was also produced in these reac-tions. The use of EPR spectroscopy indicated the pres-ence of a new type of one-coordinate, tin-centered radical, :SnAriPr4, resulting from Sn-C bond cleavage in :Sn(AriPr4)2...
April 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29643636/atypical-presentation-of-posterior-reversible-encephalopathy-syndrome-two-cases
#4
Nishant Kumar, Ranju Singh, Neha Sharma, Aruna Jain
Posterior reversible encephalopathy syndrome (PRES) is a clinico-neuroradiological entity, first described in 1996. It is commonly associated with systemic hypertension, intake of immunosuppressant drugs, sepsis and eclampsia and preeclampsia. Headache, alteration in consciousness, visual disturbances and seizures are common manifestations of PRES. Signs of pyramidal tract involvement and motor dysfunction are uncommon clinical findings. However, clinical presentation is not diagnostic. On neuroimaging, lesions are characteristically found in parieto occipital region of the brain due to vasogenic edema...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29642827/-analysis-of-hepatitis-b-virus-hbv-pres1-pres2-and-s-gene-regions-from-patient-groups-infected-with-hbv-genotype-d
#5
Eylem Karataş, Selda Erensoy, Ulus Salih Akarca, Rüçhan Sertöz
Mutations in preS and S gene regions of hepatitis B virus genome may cause immune escape and diagnostic escape HBV mutants. The aim of this study was to determine preS1, preS2 and S gene regions of HBV from HBV infected patient groups by sequence analysis and contribute to the relevant literature. Nucleic acid sequence analysis of preS and S genes of HBV PCR products from 56 archived plasma samples sent to Ege University Faculty of Medicine Medical Microbiology Department Molecular Virology laboratory, for HBV tests were determined by chain termination reaction...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29629684/hypertension-as-the-trigger-for-posterior-reversible-encephalopathy-syndrome-in-paediatric-renal-patients-an-important-diagnosis-that-should-not-be-missed
#6
J K Strong, K L Petersen, U Kala
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a reversible neurological condition presenting with seizures and visual disturbances and diagnosed on magnetic resonance imaging (MRI). Little is understood about its pathogenesis, particularly in children, but it is thought to be related to hypertension. OBJECTIVES: To review the presentation, diagnosis and outcome of PRES in paediatric renal patients at Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa, between 1 January 2000 and 31 January 2017 and compare these with published case reports to date...
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29604547/major-obstetric-hemorrhage-patients-perspective-on-the-quality-of-care
#7
Suzan M de Visser, Christian A Kirchner, Bianca G J van der Velden, Alexander C de Wit, Anneke Dijkman, Anjoke J M Huisjes, Johanna M Middeldorp, Desirée Moonen-Delarue, Jeroen van Dillen, Frank P H A Vandenbussche, Marlies E Hulscher, Hubertina C J Scheepers, Mallory D Woiski, Rosella P M G Hermens
OBJECTIVES: Major obstetric hemorrhage (MOH) is the leading cause of severe maternal morbidity and mortality, and can have a significant impact on a woman's life. This study aims to gain insight into the patients reported experiences (PREs) and outcomes (PROs) after a major obstetric hemorrhage, and to investigate which patients are most at risk for negative experiences. MATERIAL AND METHODS: A Consumer Assessment of Healthcare Providers and Systems (CAHPS) based questionnaire was developed covering items on the PREs and PROs, and send to all patients with blood loss exceeding 2500 ml in six hospitals over the period of 2008-2012...
March 20, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29592778/posterior-reversible-encephalopathy-syndrome-in-hiv-positive-patients-a-case-report-and-literature-review
#8
Erica Rm Pool, Michael Porte, Nigel Durham, Sue Urwin, Paul Laboi, Fabiola Martin
We are reporting the case of a woman who was admitted acutely to our intensive care unit without any collateral history. She was diagnosed with posterior reversible encephalopathy syndrome (PRES) as a consequence of poor adherence to anti-hypertensive, anti-diabetic and anti-retroviral medications. PRES is a rare condition, which may cause cortical blindness; contrary to its name it is not always reversible. Rapid diagnosis and aggressive management of underlying causes facilitate reversibility of PRES. We also summarise the literature on patients with HIV and PRES...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29570972/shotgun-analysis-of-diacylglycerols-enabled-by-thiol-ene-click-chemistry
#9
Sarju Adhikari, Wenpeng Zhang, Xiaobo Xie, Qinhua Chen, Yu Xia
Diacylglycerols (DAGs) are a subclass of neutral lipids actively involved in cell signaling and metabolism. Alteration in DAG me-tabolism has been associated with onset and progression of several human-related diseases. The structural diversity of DAGs and their low concentrations in biological samples call for the development of methods that are capable of sensitive identification and quantitation of each DAG species as well as rapid profiling when a biochemical pathway is perturbed. In this work, the thiol-ene click chemistry has been employed to introduce a charge-tag, namely, cysteamine (CA), at a carbon-carbon double bond (C=C) of unsaturated DAGs...
March 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29531864/posterior-reversible-encephalopathy-syndrome-pres-attributed-to-mycophenolate-mofetil-during-the-management-of-sle-a-case-report-and-review
#10
Lei Zhang, Jian Xu
Posterior reversible encephalopathy syndrome (PRES) is a rare clinical entity associated with systemic lupus erythematosus which characterized by seizure, headache, and altered mental status. The pathophysiology involves subcortical vasogenic edema secondary to hypertension and endothelial damage. PRES is reversible with withdrawal of the offending agent, strict blood pressure control, and treating the underlying disease. We report present here a patient with lupus nephritis who developed PRES following mycophenolate administration...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29528436/divergent-pres-sequences-in-virion-associated-hepatitis-b-virus-genomes-and-subviral-hbv-surface-antigen-particles-from-hbv-e-antigen-negative-patients
#11
Kai-Henrik Peiffer, Lisa Kuhnhenn, Bingfu Jiang, Antonia Mondorf, Johannes Vermehren, Viola Knop, Simone Susser, Dirk Walter, Julia Dietz, Gert Carra, Fabian Finkelmeier, Stefan Zeuzem, Christoph Sarrazin, Eberhard Hildt
Background: The hepatitis B virus (HBV) surface proteins (HBsAg) coat the viral particle and form subviral particles (SVPs). Loss of HBsAg represents a functional cure and is an important treatment goal. Methods: We analyzed the impact of the HBV genotypes A-E and pre-S mutations on SVP expression in HBeAg negative chronic HBV infected patients. A HBV genome harboring a preS1-deletion was analyzed in hepatoma cells. Results: We observed a genotype-specific ratio of the three surface proteins (SHBs/MHBs/LHBs), which reflects differences in the morphology and composition of SVPs...
March 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29526944/posterior-reversible-encephalopathy-syndrome-after-a-variety-of-combined-chemotherapies-containing-bevacizumab-for-metastatic-colon-cancer
#12
Eiichi Katada, Akira Mitsui, Shigeru Sasaki, Norihiko Uematsu, Chise Anan
A 44-year-old woman with advanced metastatic colon cancer received chemotherapies comprising XELOX, FOLFIRI/panitumumab and mFOLFOX6/bevacizumab. Fifteen months later, she presented with the acute onset of a headache, drowsiness and seizure with a fever and hypertension. Brain magnetic resonance imaging (MRI) indicated bilateral regions of signal hyperintensity in the white matter with spasms of bilateral cerebral arteries apparent on magnetic resonance angiography. Posterior reversible encephalopathy syndrome (PRES) was diagnosed, and treatments resulted in improvement of the MRI findings, but the patient experienced cerebral infarction and ultimately died of deterioration of cancer on day 26 after the onset of PRES...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29519183/intracranial-hemorrhage-in-the-setting-of-posterior-reversible-encephalopathy-syndrome-two-case-reports-and-a-review
#13
Manveer Garcha, Keithan Sivakumar, Mohammed El-Hunjul, Shweta Varade, Hussam A Yacoub
Posterior reversible encephalopathy syndrome (PRES) is clinically characterized by seizures, changes in vision, altered mental status, and headache, with associated radiologic changes on brain imaging. Intraparenchymal hemorrhage is a rare complication of PRES and an atypical initial presentation of this condition. In this report, we discuss two patients who presented with multifocal cerebral hemorrhages that were later attributed to PRES. We further expand on the pathophysiology, management, and prognosis on patients with hemorrhagic PRES...
March 14, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29515421/central-variant-posterior-reversible-encephalopathy-syndrome-with-albuminocytologic-dissociation
#14
Sang-Woo Lee, Seung-Jae Lee
Posterior reversible encephalopathy syndrome (PRES) is a disorder of reversible vasogenic brain edema which mainly involves the parieto-occipital lobes in various clinical settings. The main mechanism is known to be cerebral autoregulation failure and endothelial dysfunction leading to the disruption of the blood-brain barrier. We report the case of a 47-year-old woman with PRES which involved the brain stem and thalami, sparing the cerebral hemispheres. She was admitted to the emergency room because of acute-onset confusion...
January 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/29504632/videourodynamic-characteristics-of-interstitial-cystitis-bladder-pain-syndrome-the-role-of-bladder-outlet-dysfunction-in-the-pathophysiology
#15
Yuh-Chen Kuo, Hann-Chorng Kuo
AIMS: To investigate the characteristics of videourodynamic study (VUDS) in females with interstitial cystitis/bladder pain syndrome (IC/BPS) focusing on the etiologies of bladder outlet dysfunction (BOD) and their associations with clinical and urodynamic parameters. METHODS: IC/BPS females with complete data on symptom assessment, VUDS, the potassium sensitivity test, and cystoscopic hydrodistention were reviewed retrospectively. Diagnoses of bladder dysfunction (hypersensitive bladder, HSB) and BOD including dysfunctional voiding (DV), poor relaxation of the external urethral sphincter (PRES), and bladder neck dysfunction (BND) were made by VUDS...
March 5, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29503709/accuracy-and-reproducibility-of-3d-digital-tooth-preparations-made-by-gypsum-materials-of-various-colors
#16
Fa-Bing Tan, Chao Wang, Hong-Wei Dai, Yu-Bo Fan, Jin-Lin Song
PURPOSE: The study aimed to identify the accuracy and reproducibility of preparations made by gypsum materials of various colors using quantitative and semi-quantitative three-dimensional (3D) approach. MATERIALS AND METHODS: A titanium maxillary first molar preparation was created as reference dataset (REF). Silicone impressions were duplicated from REF and randomized into 6 groups (n=8). Gypsum preparations were formed and grouped according to the color of gypsum materials, and light-scanned to obtain prepared datasets (PRE)...
February 2018: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29501596/radioprotection-measures-during-the-learning-curve-with-hybrid-operating-rooms
#17
L Fidalgo Domingos, E M San Norberto García, D Gutiérrez Castillo, C Flota Ruiz, I Estévez Fernández, C Vaquero Puerta
BACKGROUND: Endovascular procedures come with a potential risk of radiation hazards both to patients and to the vascular staff. Classically, most endovascular interventions took place in regular operating rooms using a fluoroscopy C-arm unit controlled by a third party. Hybrid operating rooms (HOR) provide an optimal surgical suit with all the qualities of a fixed C-arm device, while allowing the device to be controlled by the surgical team. The latest studies suggest that an operator-controlled system may reduce the radiation dose...
February 28, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29494439/magnesium-sulfate-treatment-correlates-with-improved-neurological-function-in-posterior-reversible-encephalopathy-syndrome-pres-report-of-a-case
#18
Aakriti Pandita, David F Lehmann
Posterior reversible encephalopathy syndrome (PRES) is a potentially reversible failure of cerebral autoregulation managed by correction of hypertension or underlying medical condition. Nonresponding cases progress to irreversible brain damage. There is some evidence of association of hypomagnesemia with PRES. We describe a case of nonresolving PRES where use of magnesium sulfate led to improvement in neurological function and eventual recovery. Our case highlights the need for a randomized controlled trial to test the efficacy of magnesium in PRES...
March 2018: Neurologist
https://www.readbyqxmd.com/read/29490381/-hypertensive-crisis-and-posterior-reversible-encephalopathy-syndrome-pres
#19
Olaf Eberhardt
The urgency and intensity of therapeutic response to a hypertensive crisis are governed by the presence or absence of acute end-organ damage, which define hypertensive emergency and hypertensive urgency, respectively. In case of hypertensive urgency a slow and moderate lowering of blood pressure by oral antihypertensive agents seems adequate, while the approach to hypertensive emergency has to be tailored to the specific type of organ failure. Optimal blood pressure management in the context of neurovascular emergencies is made difficult by contradictory data from observational and interventional studies...
February 28, 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29480370/new-developments-in-hypertensive-encephalopathy
#20
REVIEW
Joseph B Miller, Kushak Suchdev, Namita Jayaprakash, Daniel Hrabec, Aditya Sood, Snigdha Sharma, Phillip D Levy
PURPOSE OF REVIEW: This review summarizes the latest science on hypertensive encephalopathy and posterior reversible encephalopathy syndrome (PRES). We review the epidemiology and pathophysiology of these overlapping syndromes and discuss best practices for diagnosis and management. RECENT FINDINGS: Diagnosis of hypertensive encephalopathy largely relies on exclusion of other neurological emergencies. We review the extensive causes of PRES and its imaging characteristics...
February 26, 2018: Current Hypertension Reports
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