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https://www.readbyqxmd.com/read/28439689/divergent-schwannoma-like-phenotype-in-a-pleomorphic-adenoma
#1
Srinivasa R Chandra, Farah Karim, Yeshwant B Rawal
The schwannoma-like pleomorphic adenoma is a rare histopathological variant of the pleomorphic adenoma. Five previous reports with seven cases exist in English language literature. These tumors present in the parotid gland most commonly. Intraparotid schwannomas of the facial nerve and schwannomas with glandular differentiation have also been reported. A 60-year-old male presented with an asymptomatic swelling over the left angle of the mandible. The swelling had been present for about 12 years with a recent increase in size...
April 24, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28439015/mutant-p53-perturbs-dna-replication-checkpoint-control-through-topbp1-and-treslin
#2
Kang Liu, Fang-Tsyr Lin, Joshua D Graves, Yu-Ju Lee, Weei-Chin Lin
Accumulating evidence supports the gain-of-function of mutant forms of p53 (mutp53s). However, whether mutp53 directly perturbs the DNA replication checkpoint remains unclear. Previously, we have demonstrated that TopBP1 forms a complex with mutp53s and mediates their gain-of-function through NF-Y and p63/p73. Akt phosphorylates TopBP1 and induces its oligomerization, which inhibits its ATR-activating function. Here we show that various contact and conformational mutp53s bypass Akt to induce TopBP1 oligomerization and attenuate ATR checkpoint response during replication stress...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438836/a-wnt-notch-pax7-signaling-network-supports-tissue-integrity-in-tongue-development
#3
Xiao-Jing Zhu, Xueyan Yuan, Min Wang, Yukun Fang, Yudong Liu, Xiaoyun Zhang, Xueqin Yang, Yan Li, Jianying Li, Feixue Li, Zhong-Min Dai, Mengsheng Qiu, Ze Zhang, Zunyi Zhang
The tongue is one of the major structures involved in human food intake and speech. Tongue malformations such as aglossia, microglossia, and ankyloglossia are congenital birth defects, greatly affecting individuals' quality of life. However, the molecular basis of the tissue-tissue interactions that ensure tissue morphogenesis to form a functional tongue remains largely unknown. Here we show that ShhCre-mediated epithelial deletion of Wntless (Wls), the key regulator for intracellular Wnt trafficking, leads to lingual hypoplasia in mice...
April 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28433709/pulmonary-pathobiology-induced-by-zinc-oxide-nanoparticles-in-mice-a-24-hour-and-28-day-follow-up-study
#4
Hsiao-Chi Chuang, Kai-Jen Chuang, Jen-Kun Chen, His-En Hua, Yen-Ling Shen, Wei-Neng Liao, Chii-Hong Lee, Chih-Hong Pan, Kuan-Yuan Chen, Kang-Yun Lee, Ta-Chih Hsiao, Tsun-Jen Cheng
Inhaled zinc oxide nanoparticles (ZnONPs) have high deposition rates in the alveolar region of the lungs; however, the adverse health effects of ZnONPs on the respiratory system are unclear. Herein, pathobiological responses of the respiratory system of mice that received intratracheal administration of ZnONPs were investigated by a combination of molecular and imaging (SPECT and CT) approaches. Also, normal BEAS-2B and adenocarcinoma A549 cells were used to confirm the results in mice. First, female BALB/c mice were administrated a series of doses of 20-nm ZnONPs and were compared to the phosphate-buffered saline control for 24-h and 28-day follow-up observations...
April 19, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28431798/absence-of-myoepithelial-cells-correlates-with-invasion-and-metastasis-of-carcinoma-ex-pleomorphic-adenoma
#5
P Ye, Y Gao, T Wei, G-Y Yu, X Peng
Myoepithelial cells (MECs) are implicated in the development and progression of human salivary gland tumours. Here, we investigate the potential role for MECs in invasion and metastasis of carcinoma ex pleomorphic adenoma (CXPA). Tumour tissues from 40 CXPA patients diagnosed between 1960 and 2014 were obtained. Patient samples were divided into two groups (non-invasive tumours, n=10; and frankly invasive tumours, n=30). Each group was further divided into two subgroups (metastatic tumours and non-metastatic tumours)...
April 18, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28423575/activated-notch-signaling-augments-cell-growth-in-hepatocellular-carcinoma-via-up-regulating-the-nuclear-receptor-nr4a2
#6
Bo Zhu, Lichun Sun, Wei Luo, Min Li, David H Coy, Long Yu, Wenbo Yu
Hepatocellular carcinoma (HCC) is one of the most malignant cancers. Conventional therapies are limited due to the human liver being such a unique organ and easily showing side-effects. The unclear molecular mechanisms are tough challenges for scientists searching for new and effective anti-HCC targeting drugs. We identified that the nuclear receptor NR4A2 is a novel oncogene in HCC progression. In this study, we show that NR4A2 and the notch recceptor Notch1 were expressed highly in primary HCC tissues and immortal HCC cells by using qPCR, western blot and immuno-histochemistry assays...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418858/the-mir-124-p63-feedback-loop-modulates-colorectal-cancer-growth
#7
Kuijie Liu, Hongliang Yao, Sanlin Lei, Li Xiong, Haizhi Qi, Ke Qian, Jiqiang Liu, Peng Wang, Hua Zhao
Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ΔNp63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155. Moreover, STAT1 acts as a regulator of CRC growth by targeting miR-124...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417484/well-differentiated-neuroendocrine-tumors-in-skin-terminology-and-diagnostic-utility-of-cytokeratin-5-6-and-p63
#8
Gauri Panse, Shawn E Cowper, David J Leffell, Melissa Pulitzer, Christine J Ko
BACKGROUND: Well-differentiated neuroendocrine tumors (WDNETs) in skin include metastases from visceral primary sites and very uncommonly, primary cutaneous carcinoid tumors. Cutaneous WDNET may present a diagnostic challenge and in particular can be mistaken for a benign skin adnexal tumor. In contrast to cutaneous adnexal tumors, metastatic adenocarcinomas to the skin are cytokeratin 5/6 (CK 5/6) and p63 negative in the majority of cases. It is unclear if failure to stain with CK 5/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms...
April 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28415044/long-non-coding-rna-snhg1-regulates-zinc-finger-e-box-binding-homeobox-1-expression-by-interacting-with-tap63-and-promotes-cell-metastasis-and-invasion-in-lung-squamous-cell-carcinoma
#9
Hong-Yan Zhang, Wei Yang, Fu-Shuang Zheng, Yi-Bei Wang, Ji-Bin Lu
The long non-coding RNAs (lncRNAs) have been recently shown to participate in the progression of a variety of cancers. However, the biological role of lncRNAs and the underlying mechanisms in Lung squamous cell carcinoma (SCC) or lung adenocarcinoma (AD) remain unclear. Herein, we investigated expression of 5 lncRNAS (SNHG1, NCBP2-AS2, LINC01206, SOX2-OT and LINC01419) in SCC and AD tissues. SNHG1 was one of over-expressed lncRNAs in SCC tissues. Knockdown of SNHG1 significantly inhibited the proliferation, metastasis, invasive ability and induced apoptosis of SCC cells...
April 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28413211/vaginal-brenner-tumor-with-literature-review-does-this-tumour-originate-from-walthard-nests
#10
S Park, M S Cho
Vaginal Brenner tumor is extremely rare. Only five cases have been reported in the English literature to date. Here we report a vaginal Brenner tumor in a 76-year old postmenopausal woman, who presented with a 2.5cm-sized sessile vaginal polyp. Microscopically, it showed characteristic features of Brenner tumor consisting of three components; transitional islands, glands, and dense fibrous stroma. The epithelial tumor cells were positive for GATA-3, p63 and ER, but negative for PAX8. The origin of Brenner tumors in the vagina is unclear, but previous reports suggested of Müllerian origin...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28406019/honey-extracted-polyphenolics-reduce-experimental-hypoxia-in-human-keratinocytes-culture
#11
Amrita Chaudhary, Swarnendu Bag, Provas Banerjee, Jyotirmoy Chatterjee
Hypoxic assault affects fundamental cellular processes and generates oxidative stress on healthy cells/molecules. Honey extracted polyphenolics (HEP) as a natural antioxidant reduced hypoxic cytotoxicity in this study. Different honey samples were physicochemically characterized to identify preferred (jamun) honey [pH 3.55 ± 0.04, conductivity (μs/cm) = 6.66 ± 0.14, water content % (w/w) = 14.70 ± 0.35, total solid content % (w/w) = 85.30 ± 0.35, phenol content (mg GAE/100 g) = 403.55 ± 0.35, flavonoid content (mg QE/100 g) = 276...
April 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28402962/regeneration-of-cervical-reserve-cell-like-cells-from-human-induced-pluripotent-stem-cells-ipscs-a-new-approach-to-finding-targets-for-cervical-cancer-stem-cell-treatment
#12
Masakazu Sato, Kei Kawana, Katsuyuki Adachi, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Ogishima, Satoko Eguchi, Aki Yamashita, Kensuke Tomio, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
Cervical reserve cells are epithelial progenitor cells that are pathologically evident as the origin of cervical cancer. Thus, investigating the characteristics of cervical reserve cells could yield insight into the features of cervical cancer stem cells (CSCs). In this study, we established a method for the regeneration of cervical reserve cell-like properties from human induced pluripotent stem cells (iPSCs) and named these cells induced reserve cell-like cells (iRCs). Approximately 70% of iRCs were positive for the reserve cell markers p63, CK5 and CK8...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28397771/structural-characterization-and-antifungal-studies-of-zinc-doped-hydroxyapatite-coatings
#13
Simona Liliana Iconaru, Alina Mihaela Prodan, Nicolas Buton, Daniela Predoi
The present study is focused on the synthesis, characterization and antifungal evaluation of zinc-doped hydroxyapatite (Zn:HAp) coatings. The Zn:HAp coatings were deposited on a pure Si (Zn:HAp_Si) and Ti (Zn:HAp_Ti) substrate by a sol-gel dip coating method using a zinc-doped hydroxyapatite nanogel. The nature of the crystal phase was determined by X-ray diffraction (XRD). The crystalline phase of the prepared Zn:HAp composite was assigned to hexagonal hydroxyapatite in the P63/m space group. The colloidal properties of the resulting Zn:HAp (xZn = 0...
April 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28395898/p63-adjusts-sugar-taste-of-epidermal-layers
#14
Ivano Amelio, Gerry Melino, Eleonora Candi
p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.
April 8, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28395723/-differentiation-of-human-amniotic-epithelial-cells-haecs-into-corneal-epithelial-cells-induced-by-co-culture-of-haecs-and-corneal-epithelial-cells-in-vitro
#15
Xiaoyong Liu, Jian Chen, Qing Zhou, Wei Xu, Longyan Ye, Jianting Zhou, Ling Jin
Objective To investigate the feasibility of inducing human amniotic epithelial cells (HAECs) differentiation into corneal epithelial cells (CECs) in vitro. Methods HAECs were isolated by type II collagenase and typsin. The cells were induced by human CECs in a Transwell(TM) co-culture system for 2 weeks. The expressions of cytokeratin 3+12 (CK3+12), CK14, CK19, proliferating cell nuclear antigen (PCNA) proteins in the induced HAECs were detected by immunofluorescence staining; CK12, CK14, CK19, P63 mRNAs were examined by fluorescence quantitative real-time PCR (qRT-PCR); CK3+12, CK14, CK19, P63 proteins were tested by Western blotting...
April 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28394798/sox10-and-dog1-expression-in-primary-adnexal-tumors-of-the-skin
#16
Cecilia Lezcano, Jonhan Ho, Raja R Seethala
Primary skin adnexal tumors can be challenging to classify and must be discerned from cutaneous adenocarcinoma metastases from various sites. We evaluated expression of Sox10 and DOG1 in normal cutaneous adnexa and in 194 primary skin adnexal tumors, and compared their performance in discriminating primary skin adnexal tumors from cutaneous metastatic adenocarcinomas with that of p40 and p63. In normal skin adnexa, we noted Sox10 expression in both the secretory and myoepithelial cells in eccrine glands, but only in myoepithelial cells in apocrine glands...
March 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28394568/hypervalent-bismuthides-la3mbi5-m-ti-zr-hf-and-related-antimonides-absence-of-superconductivity
#17
Taito Murakami, Takafumi Yamamoto, Fumitaka Takeiri, Kousuke Nakano, Hiroshi Kageyama
We successfully synthesized the ternary bismuthides La3MBi5 (M = Ti, Zr, Hf). These compounds crystallize in the hexagonal Hf5Sn3Cu-anti type structure (space group: P63/mcm) consisting of face-sharing MBi6 octahedral chains and hypervalent Bi linear chains, both separated by La atoms. Magnetic susceptibility and electrical resistivity measurements revealed that all of the compounds, including the solid solution La3Ti(Bi1-xSbx)5, exhibit a Pauli paramagnetic behavior without any trace of superconductivity down to 1...
April 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28391028/lncrna-expression-profile-of-%C3%AE-np63%C3%AE-in-cervical-squamous-cancers-and-its-suppressive-effects-on-lif-expression
#18
Lili Qian, Fei Xu, Xiaolin Wang, Ming Jiang, Juan Wang, Weiguo Song, Dabao Wu, Zhen Shen, Dingqing Feng, Bin Ling, Yong Cheng, Weihua Xiao, Ge Shan, Ying Zhou
We aim to determine the lncRNA targets of ΔNp63α in cervical cancer and molecular programs in cancerous differentiation. Different profiles of the lncRNAs were assayed and validated in overexpressing p63 SiHa cells (SiHa/ΔNp63α) and the control cell lines (SiHa/pCon). ENST00000422259, ENST00000447565 (Lnc-LIF-AS) and ENST00000469965, together with their related antisense mRNA DPYD (dihydropyrimidine dehydrogenase, a pyrimidine catabolic pathway gene), LIF (leukemia inhibitor factor) and FLNC (filamin C) were all notably differentially expressed in both ΔNp63α overexpression cells and knockdown cells...
April 6, 2017: Cytokine
https://www.readbyqxmd.com/read/28390135/comparative-histological-and-immunohistochemical-study-of-ameloblastomas-and-ameloblastic-carcinomas
#19
M Martínez-Martínez, A Mosqueda-Taylor, R Carlos-Bregni, F Ramoa-Pires, W Delgado-Azanero, R Neves-Silva, B Aldape-Barrios, O Paes-de Almeida
BACKGROUND: This study aimed to compare the histological and immunohistochemical characteristics of ameloblastomas (AM) and ameloblastic carcinomas (AC). MATERIAL AND METHODS: Fifteen cases of AM and 9 AC were submitted to hematoxilin and eosin (H&E) and immunohistochemical analysis with the following antibodies: cytokeratins 5,7,8,14 and 19, Ki-67, p53, p63 and the cellular adhesion molecules CD138 (Syndecan-1), E-cadherin and β-catenin. The mean score of the expression of Ki-67 and p53 labelling index (LIs) were compared between the groups using the t test...
April 8, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28383794/secretory-breast-carcinoma-with-a-papillary-predominant-pattern-an-uncommon-morphology-variant
#20
Ruohong Shui, Yufan Cheng, Qianming Bai, Wentao Yang
AIMS: Secretory breast carcinoma is a rare, low-grade, translocation-associated invasive carcinoma with unique morphology and excellent prognosis. Three patterns (microcystic, tubular, solid) have often been described in secretory carcinoma. Herein, we reported one case of secretory breast carcinoma with uncommon papillary predominant growth pattern. METHODS AND RESULTS: The patient was a 53-year-old female with a mass located in outer upper quadrant of her right breast...
April 6, 2017: Histopathology
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