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https://www.readbyqxmd.com/read/29772221/mir-301a-plays-a-pivotal-role-in-hypoxia-induced-gemcitabine-resistance-in-pancreatic-cancer
#1
Guangtao Luo, Xiang Xia, Xiaofeng Wang, Kundong Zhang, Jun Cao, Tao Jiang, Qian Zhao, Zhengjun Qiu
Hypoxia is a hallmark of pancreatic cancer (PC) and is associated with gemcitabine resistance. However, the mechanisms underlying hypoxia-induced gemcitabine resistance in PC remain greatly unknown. Our previous work showed that miR-301a, a hypoxia-sensitive miRNA, is involved in PC metastasis under hypoxia via regulation of its target gene P63. Here, we showed that miR-301a was upregulated in a NF-κB independent manner under hypoxia and promoted gemcitabine resistance under hypoxic conditions in vitro. In addition, TAp63, a member of the P63 family, reversed hypoxia-induced gemcitabine resistance by promoting degradation of HIF-1α...
May 14, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29767508/comparison-of-uranium-vi-and-thorium-iv-silicates-synthesized-via-mixed-fluxes-techniques
#2
Haijian Li, Philip Kegler, Vladislav V Klepov, Martina Klinkenberg, Dirk Bosbach, Evgeny V Alekseev
Two uranium and two thorium silicates were obtained using high temperature mixed fluxes methods. K14 (UO2 )3 Si10 O30 crystallizes in the P21 / c space group and contains open-branched sechser (six) single silicate chains, whereas K2 (UO2 )Si2 O6 crystallizes in the C2/ c space group and is built of unbranched achter (eight) silicate chains. The crystals of K14 (UO2 )3 Si10 O30 and K2 (UO2 )Si2 O6 are related by increasing U/Si molar ratios, and both structures contain the same secondary building units (SBUs), [USi6 ] heptamers...
May 16, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29763974/engineering-a-human-skin-equivalent-to-study-dermis-remodeling-and-epidermis-senescence-in-vitro-after-uva-exposure
#3
Costantino Casale, Giorgia Imparato, Francesco Urciuolo, Francesca Rescigno, Sara Scamardella, Maria Escolino, Paolo A Netti
UVA exposure strongly affects the ageing of human skin by modifying both epidermis and dermis and their cross talk as well. The possibility to get a deep understanding in vitro of such crucial mechanism would have a huge impact in the development of anti-ageing compounds. Here we present a full thickness model of human skin equivalent formed by a millimeter-sized dermis completely composed of fibroblasts embedded in their own extra-cellular matrix (ECM). We show that such endogenous nature of the dermis compartment allows the replication of the complexity of the mutual interactions occurring between cellular and extracellular components of the skin under UVA exposure: (i) oxidative stress formation in the whole tissue (dermis and epidermis); (ii) senescence of germinative layer of epidermal tissue in terms of p63, ki67 and activated caspase-3 regulation; (iii) modification of the collagenous network architecture in the dermis compartment...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29761525/ets2-is-a-prostate-basal-cell-marker-and-is-highly-expressed-in-prostate-cancers-aberrantly-expressing-p63
#4
Alba Torres, Mohammed Alshalalfa, Elai Davicioni, Anuj Gupta, Srinivasan Yegnasubramanian, Sarah J Wheelan, Jonathan I Epstein, Angelo M De Marzo, Tamara L Lotan
BACKGROUND: Rare prostate carcinomas aberrantly express p63 and have an immunophenotype intermediate between basal and luminal cells. Here, we performed gene expression profiling on p63-expressing prostatic carcinomas and compared them to usual-type adenocarcinoma. We identify ETS2 as highly expressed in p63-expressing prostatic carcinomas and benign prostate basal cells, with lower expression in luminal cells and primary usual-type adenocarcinomas. METHODS: A total of 8 p63-expressing prostate carcinomas at radical prostatectomy were compared to 358 usual-type adenocarcinomas by gene expression profiling performed on formalin fixed paraffin embedded tumor tissue using Affymetrix 1...
May 15, 2018: Prostate
https://www.readbyqxmd.com/read/29756769/prediction-of-new-phase-and-electrochemical-properties-of-li-2-s-2-for-the-application-of-li-s-batteries
#5
Y Pan, W M Guan
The intermediate product Li2 S2 plays a pivotal role in the charge/discharge process of lithium-sulfur batteries. However, the structural configuration and relevant properties of Li2 S2 are unclear. In this work, by using ab initio calculations, we present results of novel phases, average open circuit voltages ( Voc s), and electronic properties of the stable Li2 S2 . Two new Li2 S2 phases are predicted: orthorhombic ( Cmca) and orthorhombic ( Immm) structures. The calculated Voc s of hexagonal ( P63 / mmc), orthorhombic ( Cmca), and orthorhombic ( Immm) are 3...
May 14, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29755274/nut-carcinoma-of-the-sinonasal-tract-infiltrating-the-orbit-in-a-man-with-birdshot-chorioretinitis
#6
Wesley Chan, Martin J Bullock, Arif F Samad, Curtis W Archibald, J Godfrey Heathcote
A 48-year-old man with a history of birdshot chorioretinitis presented with blurry vision, retro-bulbar pain and sinusitis. Though visual acuity was unaffected, he had left optic disc oedema and mild restriction of left eye abduction. His symptoms progressed quickly, with diplopia in primary gaze, epistaxis from his left nostril, and a left relative afferent pupillary defect (RAPD). On computed tomography, there was a mass in the nasal cavity that extended through the left cribriform plate and lamina papyracea and posteriorly into the optic canal...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29752438/role-of-fgfr2b-expression-and-signaling-in-keratinocyte-differentiation-sequential-involvement-of-pkc%C3%AE-and-pkc%C3%AE
#7
Benedetta Rosato, Danilo Ranieri, Monica Nanni, Maria Rosaria Torrisi, Francesca Belleudi
The tumor suppressor epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) induces human keratinocyte early differentiation. Moreover, protein kinases C (PKCs) are known to regulate the differentiation program in several cellular contexts, including keratinocytes. Therefore, in this paper we propose to clarify if FGFR2b could play a role also in the late steps of keratinocyte differentiation and to assess if this receptor-induced process would sequentially involve PKCδ and PKCα isoforms. Immunofluorescence, biochemical, and molecular approaches, performed on 2D cultures or 3D organotypic rafts of human keratinocytes overexpressing FGFR2b by stable transduction, showed that receptor signaling induced the precocious onset and an accelerated progression of keratinocyte differentiation, indicating that FGFR2b is a crucial regulator of the entire program of keratinocyte differentiation...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29752049/the-screening-and-electron-microscopy-observation-of-mammary-analogue-secretory-carcinoma-in-chinese
#8
Yi Zhong, Liu Liu, Bin Qi, Xiaoling Song, Linhan Shen, Hongwei Li
Mammary analogue secretory carcinoma of salivary gland (MASC) is a tumor with histopathologic and immunophenotypic features mimicking secretory carcinoma of the breast harboring the ETV6 split. The expression of mammaglobin, S-100, Ki-67, P63 and ETV6 split were detected in twelve cases of acinar cell carcinoma and fourteen cases of mammary analogue secretory carcinoma of salivary gland by immunohistochemistry and fluorescence in situ hybridization respectively. The expression of ETV6 gene split was detected in fourteen mammary analogue secretory carcinomas of salivary gland with positive expression of mammaglobin...
October 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29750002/spontaneous-malignant-myoid-thymoma-in-an-aged-female-fischer-344-rat
#9
Yoshitaka Katoh, Tsuyoshi Ito, Yuko Shimada, Aya Ohnuma-Koyama, Naofumi Takahashi, Yoshimasa Okazaki, Atsushi Shiga, Maki Kuwahara, Toshinori Yoshida, Takanori Harada
A whitish mass approximately 30 mm in diameter was noted in the anterior mediastinum of a 67-week-old female Fischer 344 rat. Histopathologically, two types of tumor cells were identified on the basis of morphologic features: epithelial tumor cells with a tubular or cord-like growth pattern and rhabdomyosarcomatous tumor cells characterized by the presence of cross-striations. Immunohistochemically, the epithelial tumor cells reacted positively for cytokeratin AE1/AE3, and some reacted positively for p63, which is expressed in normal thymic epithelial cells...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29743728/spatially-correlated-phenotyping-reveals-k5-positive-luminal-progenitor-cells-and-p63-k5-14-positive-stem-cell-like-cells-in-human-breast-epithelium
#10
Werner Boecker, Laura van Horn, Göran Stenman, Christine Stürken, Udo Schumacher, Thomas Loening, Lukas Liesenfeld, Eberhard Korsching, Doreen Gläser, Katharina Tiemann, Igor Buchwalow
Understanding the mechanisms regulating human mammary epithelium requires knowledge of the cellular constituents of this tissue. Different and partially contradictory definitions and concepts describing the cellular hierarchy of mammary epithelium have been proposed, including our studies of keratins K5 and/or K14 as markers of progenitor cells. Furthermore, we and others have suggested that the p53 homolog p63 is a marker of human breast epithelial stem cells. In this investigation, we expand our previous studies by testing whether immunohistochemical staining with monospecific anti-keratin antibodies in combination with an antibody against the stem cell marker p63 might help refine the different morphologic phenotypes in normal breast epithelium...
May 9, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29735981/grainyhead-like-2-grhl2-knockout-abolishes-oral-cancer-development-through-reciprocal-regulation-of-the-map-kinase-and-tgf-%C3%AE-signaling-pathways
#11
Wei Chen, Kyung L Kang, Abdullah Alshaikh, Saaket Varma, Yi-Ling Lin, Ki-Hyuk Shin, Reuben Kim, Cun-Yu Wang, No-Hee Park, Katharina Walentin, Kai M Schmidt-Ott, Mo K Kang
Grainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse regulation between GRHL2 and TGF-β in epithelial plasticity and potential carcinogenesis. Here, we report the role of GRHL2 in oral carcinogenesis in vivo using a novel Grhl2 knockout (KO) mouse model and the underlying mechanism involving its functional interaction with TGF-β signaling. We developed epithelial-specific Grhl2 conditional KO mice by crossing Grhl2 floxed mice with those expressing CreER driven by the K14 promoter...
May 8, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29735662/stxbp4-regulates-apc-c-mediated-p63-turnover-and-drives-squamous-cell-carcinogenesis
#12
Susumu Rokudai, Yingchun Li, Yukihiro Otaka, Michiru Fujieda, David M Owens, Angela M Christiano, Masahiko Nishiyama, Carol Prives
Levels of the N-terminally truncated isoform of p63 (ΔN p63), well documented to play a pivotal role in basal epidermal gene expression and epithelial maintenance, need to be strictly regulated. We demonstrate here that the anaphase-promoting complex/cyclosome (APC/C) complex plays an essential role in the ubiquitin-mediated turnover of ΔNp63α through the M-G1 phase. In addition, syntaxin-binding protein 4 (Stxbp4), which we previously discovered to bind to ΔNp63, can suppress the APC/C-mediated proteolysis of ΔNp63...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29733437/complex-mammary-carcinoma-with-metastases-to-lymph-nodes-subcutaneous-tissue-and-multiple-joints-in-a-dog
#13
Maggie R McCourt, Alexandra M Dieterly, Paige E Mackey, Shane D Lyon, Theresa E Rizzi, Jerry W Ritchey
An 8-year-old, intact female, mixed-breed dog presented to the Oklahoma State University Boren Veterinary Medical Teaching Hospital for evaluation of progressive lameness and joint effusion of multiple joints. Physical examination revealed joint effusion of the elbow, hock, and stifle joints bilaterally, enlarged left axillary and right popliteal lymph nodes, a subcutaneous mass over the left elbow, and a subcutaneous mass involving the left second and third mammary glands. Cytologic examination of the mammary mass, enlarged lymph nodes, and joint fluid from most affected joints revealed a monomorphic population of loosely cohesive neoplastic epithelial cells...
May 7, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29729907/technical-note-p40-antibody-as-a-replacement-for-p63-antibody-in-bovine-mammary-immunohistochemistry
#14
C L M Parsons, H L M Tucker, R M Akers, K M Daniels
Tumor protein 63 (p63) is a nuclear antigen found in basal epithelial cells. To date, 10 isoforms of p63 have been identified, falling into 2 major groups identified by presence or absence of an N-terminal transactivation domain (TAp63 and ΔNp63, respectively). Literature suggests that ΔNp63 is the predominant form expressed in basal epithelial cells and myoepithelial cells (MYEC). The mouse anti-p63 antibody, clone 4B1E12, has been used as a specific nuclear marker for bovine MYEC. Unfortunately, this antibody is no longer commercially available...
May 2, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29725001/ablation-of-beta-subunit-of-protein-kinase-ck2-in-mouse-oocytes-causes-follicle-atresia-and-premature-ovarian-failure
#15
Qiu-Xia Liang, Zhen-Bo Wang, Fei Lin, Chun-Hui Zhang, Hong-Mei Sun, Liang Zhou, Qian Zhou, Heide Schatten, Filhol-Cochet Odile, Boldyreff Brigitte, Qing-Yuan Sun, Wei-Ping Qian
Premature ovarian failure (POF), a major cause of female infertility, is a complex disorder, but the molecular mechanisms underlying the disorder are only poorly understood. Here we report that protein kinase CK2 contributes to maintaining follicular survival through PI3K/AKT pathway and DNA damage response pathway. Targeted deletion of CK2β in mouse oocytes from the primordial follicle stage resulted in female infertility, which was attributed to POF incurring by massive follicle atresia. Downregulated PI3K/AKT signaling was found after CK2β deletion, indicated by reduced level of phosphorylated AKT (S473, T308, and S129) and altered AKT targets related to cell survival...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29723365/lymphoepithelioma-like-carcinoma-of-the-skin
#16
Cristiano Claudino Oliveira, Vinicius Cardoso Nóbrega, Mariângela Esther Alencar Marques
Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29716728/p63-silencing-induces-reprogramming-of-cardiac-fibroblasts-into-cardiomyocyte-like-cells
#17
Vivekkumar Patel, Vivek P Singh, Jaya Pratap Pinnamaneni, Deepthi Sanagasetti, Jacqueline Olive, Megumi Mathison, Austin Cooney, Elsa R Flores, Ronald G Crystal, Jianchang Yang, Todd K Rosengart
OBJECTIVE: Reprogramming of fibroblasts into induced cardiomyocytes represents a potential new therapy for heart failure. We hypothesized that inactivation of p63, a p53 gene family member, may help overcome human cell resistance to reprogramming. METHODS: p63 Knockout (-/- ) and knockdown murine embryonic fibroblasts (MEFs), p63-/- adult murine cardiac fibroblasts, and human cardiac fibroblasts were assessed for cardiomyocyte-specific feature changes, with or without treatment by the cardiac transcription factors Hand2-Myocardin (HM)...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29672360/cutaneous-metastasis-of-adenocarcinoma-of-the-ampulla-of-vater
#18
Angel Fernandez-Flores, David S Cassarino
Cutaneous metastases from an adenocarcinoma of the Ampulla of Vater are very rare, with only a few cases previously reported. We present here an additional case in a 57-year-old woman who complained of a painful growth on her frontal scalp that she had noticed 4 months earlier. Her medical history included an ampullary adenocarcinoma, which was diagnosed 4 years ago, excised through a Whipple procedure, and treated using chemotherapy and radiotherapy. The scalp biopsy showed a dermal and epidermotropic well-differentiated glandular neoplasm with abundant neutrophils within the luminae of the tumoral glands...
April 17, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29671211/characterisation-of-dog-1-expression-in-salivary-gland-tumours-and-comparison-with-myoepithelial-markers
#19
Syed A Khurram, Paul M Speight
DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29662640/potential-therapeutic-targets-of-tp53-gene-in-the-context-of-its-classically-canonical-functions-and-its-latest-non-canonical-functions-in-human-cancer
#20
REVIEW
Toshimichi Tanaka, Masahiko Watanabe, Keishi Yamashita
In normal tissue, p53 protein has a wide range of functions involving cell homeostasis; its mutation, however, permits a carcinogenic acquisition of function. TP53 gene mutation is a major genomic aberration in various human cancers and is a critical event in the multi-step carcinogenesis process. TP53 mutation is clinically relevant for the molecular classification of carcinogenesis, as most recently described rigorously by the Cancer Genome Atlas Research Network. TP53 gene mutation has been considered to work as a tumor suppressor gene through the loss of its transcriptional activity, which is designated as a canonical function...
March 23, 2018: Oncotarget
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