keyword
MENU ▼
Read by QxMD icon Read
search

P63

keyword
https://www.readbyqxmd.com/read/29144557/penile-warty-mucoepidermoid-carcinoma-with-features-of-stratified-mucin-producing-intraepithelial-lesion-and-invasive-stratified-mucin-producing-carcinoma
#1
Kenji Yorita, Naoto Kuroda, Takushi Naroda, Masato Tamura, Chisato Ohe, Mukul Divatia, Mahul B Amin, Antonio L Cubilla, Dimitry V Kazakov, Ondrej Hes, Michael Michal, Michal Michal
AIMS: Stratified mucin-producing intraepithelial lesion (SMILE) and invasive stratified mucin-producing carcinoma (ISMC) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE/ISMC features. METHODS AND RESULTS: A 62-year-old Japanese man had a glans penis lesion of one and a half years duration, suggesting malignancy. Partial penectomy and left inguinal lymphadenectomy were performed...
November 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29142867/immunohistochemical-evaluation-of-p63-and-cyclin-d1-in-oral-squamous-cell-carcinoma-and-leukoplakia
#2
Sunit B Patel, Bhari S Manjunatha, Vandana Shah, Nishit Soni, Rakesh Sutariya
Objectives: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63 expression in leukoplakia and OSCC to investigate the possible correlation of both markers with grade of dysplasia and histological grade of OSCC. Materials and Methods: The study included a total of 60 cases, of which 30 were diagnosed with OSCC and 30 with leukoplakia, that were evaluated immunohistochemically for p63 and cyclin D1 expression...
October 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29140091/evidence-for-symmetry-reduction-in-ti3-al1-%C3%AE-cu%C3%AE-c2-max-phase-solid-solutions
#3
Mustapha Nechiche, Thierry Cabioc'h, Elad N Caspi, Oleg Rivin, Andreas Hoser, Véronique Gauthier-Brunet, Patrick Chartier, Sylvain Dubois
Ti3[Al1-δCuδ]C2 MAX phase solid solutions have been synthesized by sintering compacted Ti3AlC2-Cu composites produced by mechanical milling. Using X-ray and neutron diffraction techniques, it is demonstrated that the Cu mixing into the Al site is accompanied by lattice distortion, which leads to symmetry reduction from a hexagonal to a monoclinic structure. Such symmetry reduction likely results from this mixing through deviation of the A-site position from the special (0, 0, (1)/4) position within the P63/mmc space group of the original Ti3AlC2 structure...
November 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29131609/li7-teo3-3f-a-lithium-fluoride-tellurite-with-large-second-harmonic-generation-responses-and-a-short-ultraviolet-cutoff-edge
#4
Jiang-He Feng, Chun-Li Hu, Hou-Ping Xia, Fang Kong, Jiang-Gao Mao
Here, the combination of the strong electropositive lithium and the most electronegative fluorine with the TeO3 group afforded the first lithium fluoride tellurite, namely, Li7(TeO3)3F (P63), which was synthesized by solid-state reactions. Its structure features a novel three-dimensional anionic framework of [Li7O9F](12-) composed of LiO3F and LiO4 tetrahedra with one-dimensional hexagonal tunnels of 12-membered rings along the c-axis, filled by the "isolated" ψ-TeO3 tetrahedra. Notably, this compound displays the largest band gap of 4...
November 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29130604/expanding-the-phenotypic-spectrum-of-tp63-related-disorders-including-the-first-set-of-monozygotic-twins
#5
Tara Wenger, Dong Li, Margaret H Harr, Wen-Hann Tan, Renata Pellegrino, Zornitza Stark, Hakon Hakonarson, Elizabeth J Bhoj
Individuals with Tumor Protein P63 (TP63)-related disorders are known to present with a range of phenotypic features, including ectrodactyly, ectodermal dysplasia, cleft lip/palate, Rapp-Hodgkin, Hay-Wells, and limb-mammary syndromes. We present six individuals from three families, including a set of monozygotic twins, with pathogenic TP63 variants who had novel clinical findings. The twins were discordant for cleft lip and palate, and the type of hand malformations, but concordant for choanal atresia, and bilateral volar nail...
November 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29127687/nuclear-inverse-polarity-papillary-lesions-lacking-myoepithelial-cells-a-report-of-two-cases
#6
Shinya Tajima, Ichiro Maeda, Yoshio Aida, Akio Kazama, Hirotaka Koizumi, Masatomo Doi, Akira Endo, Motohiro Chosokabe, Keiko Kishimoto, Takafumi Ono, Koichiro Tsugawa, Masayuki Takagi
Here, cases of a 68- (Case 1) and a 44-year-old (Case 2) female are presented. They had an abnormality in the breast, and came to our hospital for further examination and treatment. Radiologically, malignancy could not completely excluded so breast excision was performed. Histologically, both cases revealed papillary neoplastic lesions lined by fibrovascular core and nuclear inverse polarity without atypia. Loss of myoepithelial cells was observed by HE, p63, and calponin. Previous report indicate CK5/6, ER, p63 and MUC3 are important for distinguishing between papillary lesions according to the differential index (based on Allred score) of ([ER total score] + [MUC3 total score])/([CK5/6 total score] + [p63 total score] + 1)...
November 10, 2017: Pathology International
https://www.readbyqxmd.com/read/29123224/structure-and-photoluminescence-properties-of-red-emitting-apatite-type-phosphor-nay9-sio4-6o2-sm-3-with-excellent-quantum-efficiency-and-thermal-stability-for-solid-state-lighting
#7
Lefu Mei, Haikun Liu, Libing Liao, Yuanyuan Zhang, R Vasant Kumar
A novel red-emitting phosphor NaY9(SiO4)6O2:Sm(3+) (NYS:Sm(3+)) was synthesized and the X-ray diffraction and high-resolution TEM testified that the NYS compound belongs to the apatite structure which crystallized in a hexagonal unit cell with space group P63/m. The novel phosphor boasts of such three advantageous properties as perfect compatible match with the commercial UV chips, 73.2% quantum efficiency and 90.9% thermal stability at 150 °C. Details are as follows. NYS:Sm(3+) phosphor showed obvious absorption in the UV regions centered at 407 nm, which can be perfectly compatible with the commercial UV chips...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29120527/castle-tumor-of-the-parotid-first-documented-case-literature-review-and-genetic-analysis-of-the-cancer
#8
Eugene Hung Chih Wong, Nora Tetter, Alexandar Tzankov, Laurent Muller
BACKGROUND: Carcinoma showing thymus-like elements (CASTLE) is a rare tumor that normally affects the thyroid gland and was thought to arise from either the remnants of the branchial pouch or the ectopic cervical thymic tissue. These tumors show strong immunopositivity for CD5, P63, and CD117. Most CASTLE of the thyroid gland is treated with surgery with or without adjuvant radiotherapy or chemotherapy. METHOD: A 55-year-old woman presented with a slow-growing right parotid mass...
November 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/29117942/er%C3%AE-sensitizes-nsclc-to-chemotherapy-by-regulating-dna-damage-response
#9
Fotis Nikolos, Christoforos Thomas, Igor Bado, Jan-Ake Gustafsson
The expression of wild-type estrogen receptor β (ESR2/ERβ1) correlates with clinical outcome in patients with Non-Small Cell Lung Cancer (NSCLC). However, the molecular mechanism that accounts for this association is currently poorly understood. ERβ1 was previously linked to chemotherapy response in patients with breast cancer and in breast cancer cells. The effect of the receptor in NSCLC cells after chemotherapy treatment, a common remedy for advanced NSCLC, has not been studied. Here, upregulation of ERβ1 increases the sensitivity of NSCLC cells to treatment with doxorubicin and etoposide...
November 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29116648/nuclear-quantum-effects-induce-metallization-of-dense-solid-molecular-hydrogen
#10
Sam Azadi, Ranber Singh, Thomas D Kühne
We present an accurate computational study of the electronic structure and lattice dynamics of solid molecular hydrogen at high pressure. The band-gap energies of the C2/c, Pc, and P63/m structures at pressures of 250, 300, and 350 GPa are calculated using the diffusion quantum Monte Carlo (DMC) method. The atomic configurations are obtained from ab initio path-integral molecular dynamics (PIMD) simulations at 300 K and 300 GPa to investigate the impact of zero-point energy and temperature-induced motion of the protons including anharmonic effects...
November 8, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29108232/tap63%C3%AE-and-%C3%AE-np63%C3%AE-are-regulated-by-rbm38-via-mrna-stability-and-have-an-opposing-function-in-growth-suppression
#11
Wensheng Yan, Yanhong Zhang, Xinbin Chen
The p63 gene is expressed as TAp63 from the P1 promoter and as ΔNp63 from the P2 promoter. Through alternative splicing, five TA and five ΔN isoforms (α-ε) are expressed. Isoforms α-β and δ share an identical 3' untranslated region (3'UTR) whereas isoform γ has a unique 3'UTR. Recently, we found that RBM38 RNA-binding protein is a target of p63 and RBM38 in turn regulates p63α/β expression via mRNA stability. However, it is uncertain whether p63γ has a unique biological activity and whether p63γ is regulated by RBM38...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107083/p63-and-p73-repress-cxcr5-chemokine-receptor-gene-expression-in-p53-deficient-mcf-7-breast-cancer-cells-during-genotoxic-stress
#12
Nikita A Mitkin, Alisa M Muratova, George V Sharonov, Kirill V Korneev, Ekaterina N Sviriaeva, Dmitriy Mazurov, Anton M Schwartz, Dmitry V Kuprash
Many types of chemotherapeutic agents induce of DNA-damage that is accompanied by activation of p53 tumor suppressor, a key regulator of tumor development and progression. In our previous study we demonstrated that p53 could repress CXCR5 chemokine receptor gene in MCF-7 breast cancer cells via attenuation of NFkB activity. In this work we aimed to determine individual roles of p53 family members in the regulation of CXCR5 gene expression under genotoxic stress. DNA-alkylating agent methyl methanesulfonate caused a reduction in CXCR5 expression not only in parental MCF-7 cells but also in MCF-7-p53off cells with CRISPR/Cas9-mediated inactivation of the p53 gene...
November 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29103953/wnt-mediated-regulation-of-foxo1-constitutes-a-critical-axis-maintaining-pubertal-mammary-stem-cell-homeostasis
#13
Amulya Sreekumar, Michael J Toneff, Eajer Toh, Kevin Roarty, Chad J Creighton, George K Belka, Dong-Kee Lee, Jianming Xu, Lewis A Chodosh, JoAnne S Richards, Jeffrey M Rosen
Puberty is characterized by dynamic tissue remodeling in the mammary gland involving ductal elongation, resolution into the mature epithelial bilayer, and lumen formation. To decipher the cellular mechanisms underlying these processes, we studied the fate of putative stem cells, termed cap cells, present in terminal end buds of pubertal mice. Employing a p63(CreERT2)-based lineage-tracing strategy, we identified a unipotent fate for proliferative cap cells that only generated cells with basal features. Furthermore, we observed that dislocated "cap-in-body" cells underwent apoptosis, which aided lumen formation during ductal development...
October 31, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29103147/master-regulatory-role-of-p63-in-epidermal-development-and-disease
#14
REVIEW
Eduardo Soares, Huiqing Zhou
The transcription factor p63 is a master regulator of epidermal development. Mutations in p63 give rise to human developmental diseases that often manifest epidermal defects. In this review, we summarize major p63 isoforms identified so far and p63 mutation-associated human diseases that show epidermal defects. We discuss key roles of p63 in epidermal keratinocyte proliferation and differentiation, emphasizing its master regulatory control of the gene expression pattern and epigenetic landscape that define epidermal fate...
November 4, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29097842/a-spontaneous-basal-cell-carcinoma-with-pulmonary-metastasis-in-a-6-week-old-sd-rat
#15
Asami Urashima, Kinji Kobayashi, Yuji Sasaki, Kimiaki Hirakawa, Hiroshi Maeda
To our knowledge, this is the first report on basal cell carcinoma with lung metastasis in a rat. A 6-week-old male Sprague-Dawley rat presented ulceration of the oral mucosa with surrounding tumor growth and white nodules in the lung. Microscopically, the mass showed solid, sheet-like growth with a partially lobular pattern and invaded the gingival mucosa, maxilla, and nasal submucosa. The nuclei of tumor cells were round to oval in shape with basophilic cytoplasm and a large number of mitotic figures. The pulmonary nodules were almost identical to the maxillary tumor in histopathological characteristics...
October 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29094931/superconductivity-of-pressure-stabilized-vanadium-hydrides
#16
Xiaofeng Li, Feng Peng
The study of the high-temperature superconductive property in compressed hydrogen (H)-rich hydrides has been motivated by hydrides, which become superconducting at low pressure due to chemical precompression. In the present study, we report the first-principles structure searches for stable vanadium(V) hydrides over a pressure scope 0-200 GPa, where stable unexpected stoichiometries of H-rich V hydrides (e.g., VH3, VH5, and VH8) emerge. These dense H-rich V hydrides are metallic with a strong ionic feature, and the coordination number of metal V gradually increases with H content...
November 2, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29093739/aggressive-adenoid-cystic-carcinoma-of-maxillary-sinus-in-a-43-year-old-male-rare-case-report-and-review-of-literature
#17
Koorosh Rahmani, Shokouh Taghipour Zahir, Mohammad Baghi Yazdi, Alireza Navabazam
Adenoid cystic carcinoma (ACC) is a rare malignant tumor, mostly involving the minor salivary glands. Herein, we present a case of ACC in a 43-year-old man with symptoms of dental abscess as the initial presentation of the tumor. In spiral computed tomography (CT) scan, soft tissue mass with the erosion of maxillary sinus wall on the right side of the alveolar ridge was evident. Histopathological examination of the excised tumor with immunohistochemical studies (C-kit, Vimentin, pan-cytokeratin, p53, p63, and ki67 positive reaction) confirmed grade 2 ACC in the maxillary sinus...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29084218/concerted-regulation-of-npc2-binding-to-endosomal-lysosomal-membranes-by-bis-monoacylglycero-phosphate-and-sphingomyelin
#18
Giray Enkavi, Heikki Mikkolainen, Burçin Güngör, Elina Ikonen, Ilpo Vattulainen
Niemann-Pick Protein C2 (npc2) is a small soluble protein critical for cholesterol transport within and from the lysosome and the late endosome. Intriguingly, npc2-mediated cholesterol transport has been shown to be modulated by lipids, yet the molecular mechanism of npc2-membrane interactions has remained elusive. Here, based on an extensive set of atomistic simulations and free energy calculations, we clarify the mechanism and energetics of npc2-membrane binding and characterize the roles of physiologically relevant key lipids associated with the binding process...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29079177/sinonasal-nut-carcinoma-clinicopathological-and-cytogenetic-analysis-with-autopsy-findings
#19
Hiroshi Minato, Eriko Kobayashi, Satoko Nakada, Nozomu Kurose, Mio Tanaka, Yukichi Tanaka, Shioto Suzuki, Fumihiko Tanioka, Yutaka Saikawa, Takaki Miwa, Takayuki Nojima
Nuclear protein in testis (NUT) carcinoma is a rare malignant neoplasm with an undifferentiated morphology. Its diagnosis is often difficult, especially as the sinonasal tract gives rise to many tumors with undifferentiated morphologies. Not many cases of sinonasal NUT carcinomas have been reported, and its clinicopathological features have not been sufficiently clarified. In this study, we performed a clinicopathological study of 4 patients with sinonasal NUT carcinoma, including wide-ranging immunohistochemical tests and cytogenetic analyses using fluorescence in situ hybridization and DNA sequencing...
October 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29078349/requirement-of-zinc-transporter-zip10-for-epidermal-development-implication-of-the-zip10-p63-axis-in-epithelial-homeostasis
#20
Bum-Ho Bin, Jinhyuk Bhin, Mikiro Takaishi, Koh-Ei Toyoshima, Saeko Kawamata, Kana Ito, Takafumi Hara, Takashi Watanabe, Tarou Irié, Teruhisa Takagishi, Su-Hyon Lee, Haeng-Sun Jung, Sangchul Rho, Juyeon Seo, Dong-Hwa Choi, Daehee Hwang, Haruhiko Koseki, Osamu Ohara, Shigetoshi Sano, Takashi Tsuji, Kenji Mishima, Toshiyuki Fukada
Skin tissues, in particular the epidermis, are severely affected by zinc deficiency. However, the zinc-mediated mechanisms that maintain the cells that form the epidermis have not been established. Here, we report that the zinc transporter ZIP10 is highly expressed in the outer root sheath of hair follicles and plays critical roles in epidermal development. We found that ZIP10 marked epidermal progenitor cell subsets and that ablating Zip10 caused significant epidermal hypoplasia accompanied by down-regulation of the transactivation of p63, a master regulator of epidermal progenitor cell proliferation and differentiation...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
15250
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"