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https://www.readbyqxmd.com/read/28645112/tap63%C3%AE-and-%C3%AE-np63%C3%AE-are-regulated-by-rbm38-via-mrna-stability-and-have-an-opposing-function-in-growth-suppression
#1
Wensheng Yan, Yanhong Zhang, Xinbin Chen
The p63 gene is expressed as TAp63 from the P1 promoter and as ΔNp63 from the P2 promoter. Through alternative splicing, five TA and five ΔN isoforms (α-ε) are expressed. Isoforms α-β and δ share an identical 3' untranslated region (3'UTR) whereas isoform γ has a unique 3'UTR. Recently, we found that RBM38 RNA-binding protein is a target of p63 and RBM38 in turn regulates p63α/β expression via mRNA stability. However, it is uncertain whether p63γ has a unique biological activity and whether p63γ is regulated by RBM38...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28645102/expression-of-p63-and-cd44-in-oral-squamous-cell-carcinoma-and-correlation-with-clinicopathological-parameters
#2
Nasrollah Saghravanian, Kazem Anvari, Narges Ghazi, Bahram Memar, Maryam Shahsavari, Monavar Afzal Aghaee
Squamous cell carcinoma (SCC) is the sixth most frequent malignant tumor of the head and neck region. Despite advances in therapeutic options over the last decades, the rate of mortality and morbidity has not been improved markedly. A small subset of cells, cancer stem cells (CSCs), with self-renewal properties have become a major focus of current cancer research. CD44 and p63 are identified as candidate stem cell markers in normal squamous epithelium and SCC. The role of these markers in oral squamous cell carcinoma (OSCC) is still debatable...
June 15, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28640877/identification-of-c-ebp%C3%AE-as-a-novel-target-of-the-hpv8-e6-protein-regulating-mir-203-in-human-keratinocytes
#3
Anna M Marthaler, Marta Podgorska, Pascal Feld, Alina Fingerle, Katrin Knerr-Rupp, Friedrich Grässer, Hans Smola, Klaus Roemer, Elke Ebert, Yoo-Jin Kim, Rainer M Bohle, Cornelia S L Müller, Jörg Reichrath, Thomas Vogt, Magdalena Malejczyk, Sławomir Majewski, Sigrun Smola
Patients suffering from Epidermodysplasia verruciformis (EV), a rare inherited skin disease, display a particular susceptibility to persistent infection with cutaneous genus beta-human papillomavirus (beta-HPV), such as HPV type 8. They have a high risk to develop non-melanoma skin cancer at sun-exposed sites. In various models evidence is emerging that cutaneous HPV E6 proteins disturb epidermal homeostasis and support carcinogenesis, however, the underlying mechanisms are not fully understood as yet. In this study we demonstrate that microRNA-203 (miR-203), a key regulator of epidermal proliferation and differentiation, is strongly down-regulated in HPV8-positive EV-lesions...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28637946/basal-cell-adenocarcinoma-in-the-gland-of-the-third-eyelid-of-a-brown-bear-ursus-arctos
#4
Hiroki Sakai, Minami Goto, Takeshi Komatsu
The right third eyelid of an adult female brown bear (Ursus arctos) was swollen and removed. Histopathology revealed a tumor exhibiting proliferation with mild infiltration, consisting of multi-stratified glandular structures of the innermost laminal neoplastic cells and the basaloid neoplastic cells, and with eosinophilic thick basal lamina material around the glandular structures. Both types of neoplastic cells exhibited moderate anisokaryosis, and mitotic figures were observed in the basaloid neoplastic cells...
June 22, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28637720/notch1-maintains-dormancy-of-olfactory-horizontal-basal-cells-a-reserve-neural-stem-cell
#5
Daniel B Herrick, Brian Lin, Jesse Peterson, Nikolai Schnittke, James E Schwob
The remarkable capacity of the adult olfactory epithelium (OE) to regenerate fully both neurosensory and nonneuronal cell types after severe epithelial injury depends on life-long persistence of two stem cell populations: the horizontal basal cells (HBCs), which are quiescent and held in reserve, and mitotically active globose basal cells. It has recently been demonstrated that down-regulation of the ΔN form of the transcription factor p63 is both necessary and sufficient to release HBCs from dormancy. However, the mechanisms by which p63 is down-regulated after acute OE injury remain unknown...
June 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28636255/recombinant-human-serum-albumin-for-corneal-preservation
#6
Mohit Parekh, Hossein Elbadawy, Gianni Salvalaio, Marie-Claude Amoureux, Enzo Di Iorio, Denis Fortier, Diego Ponzin, Stefano Ferrari, Alessandro Ruzza
PURPOSE: To study the performance of a completely synthetic organ culture (OC) preservation system containing recombinant human serum albumin (rHSA) for preservation of human donor corneas. METHODS: Twenty-four paired donor corneas were randomly collected, and one cornea from each donor was preserved in synthetic (experimental) and serum-based media (control). The tissues were assessed at day 0; after 6 days of preservation at room temperature (RT) in Cornea Trans(®) and Cornea Prep II(®) ; after 28 days at 31°C in Cornea Syn(®) [with rHSA] and Cornea Max(®) [with foetal calf serum (FCS)] and; 4-day post deswelling in Cornea Trans(®) and Cornea Jet(®) ...
June 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28635988/salivary-epithelial-myoepithelial-carcinoma-clinical-morphological-and-molecular-features
#7
R De Cecio, M Cantile, F Fulciniti, G Botti, M P Foschini, N S Losito
Epithelial-myoepithelial carcinoma (EMC) is a rare biphasic tumor accounting for less than 2% of all salivary gland malignancies. It presents as a slowly growing, asymptomatic small size mass, with ulceration of overlying mucosa in some cases. Microscopically, it is characterized by glands lined by the simultaneous presence of two different cell components, inner epithelial cells and outer myoepithelial cells. Immunohistochemical staining of myoepithelial cells is variably positive for vimentin, Smooth Muscle Actin (SMA), Muscle Specific Actin (MSA), S100, Smooth Muscle Myosin Heavy Chain I(SM-MHC), calponin and p63...
March 2017: Pathologica
https://www.readbyqxmd.com/read/28635633/new-insights-in-thyroid-cancer-and-p53-family-proteins
#8
REVIEW
Livia Manzella, Stefania Stella, Maria Stella Pennisi, Elena Tirrò, Michele Massimino, Chiara Romano, Adriana Puma, Martina Tavarelli, Paolo Vigneri
Thyroid cancers are common endocrine malignancies that comprise tumors with different clinical and histological features. Indeed, papillary and follicular thyroid cancers are slow-growing, well-differentiated tumors, whereas anaplastic thyroid cancers are undifferentiated neoplasias that behave much more aggressively. Well-differentiated thyroid carcinomas are efficiently cured by surgery and radioiodine, unlike undifferentiated tumors that fail to uptake radioactive iodine and are usually resistant to chemotherapy...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28632777/immunohistochemiocal-subtyping-using-ck20-and-ck5-can-identify-urothelial-carcinomas-of-the-upper-urinary-tract-with-a-poor-prognosis
#9
Danijel Sikic, Bastian Keck, Sven Wach, Helge Taubert, Bernd Wullich, Peter J Goebell, Andreas Kahlmeyer, Peter Olbert, Philipp Isfort, Wilhelm Nimphius, Arndt Hartmann, Johannes Giedl
PURPOSE: Genome-wide analyses revealed basal and luminal subtypes of urothelial carcinomas of the bladder. It is unknown if this subtyping can also be applied to upper tract urothelial carcinomas. MATERIALS AND METHODS: Tumor samples from 222 patients with upper tract urothelial carcinomas who were treated with radical nephroureterectomy were analyzed for the expression of seven basal/luminal immunohistochemical markers (CK5, EGFR, CD44, CK20, p63, GATA3, FOXA1)...
2017: PloS One
https://www.readbyqxmd.com/read/28630050/effectiveness-of-computer-aided-diagnosis-cadx-of-breast-pathology-using-immunohistochemistry-results-of-core-needle-biopsy-samples-for-synaptophysin-oestrogen-receptor-and-ck14-p63-for-classification-of-epithelial-proliferative-lesions-of-the-breast
#10
Ichiro Maeda, Manabu Kubota, Jiro Ohta, Kimika Shinno, Shinya Tajima, Yasushi Ariizumi, Masatomo Doi, Yoshiyasu Oana, Yoshihide Kanemaki, Koichiro Tsugawa, Takahiko Ueno, Masayuki Takagi
AIMS: The aim of this study was to develop a computer-aided diagnosis (CADx) system for identifying breast pathology. METHODS: Two sets of 100 consecutive core needle biopsy (CNB) specimens were collected for test and validation studies. All 200 CNB specimens were stained with antibodies targeting oestrogen receptor (ER), synaptophysin and CK14/p63. All stained slides were scanned in a whole-slide imaging system and photographed. The photographs were analysed using software to identify the proportions of tumour cells that were positive and negative for each marker...
June 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28627879/the-%C3%AE-1-%C3%AE-2-motif-of-the-rnase-h-domain-of-hiv-1-rt-is-responsible-for-conferring-open-conformation-to-p66-subunit-by-displacing-the-connection-domain-from-the-polymerase-cleft
#11
Ashutosh K Pandey, Updesh Dixit, Vladyslav Kholodovych, Thomas W Comollo, Virendra N Pandey
Heterodimeric HIV-1 RT is composed of p66 and p51 subunits. While in the p51 subunit, the connection domain is tucked in the polymerase cleft,; it is effectively displaced from the cleft of the catalytically active p66 subunit. How is the connection domain relocated from the polymerase cleft of p66? Does RNase H domain have any role in this process? To answer this question, we extended the C-terminal region of p51 by stepwise addition of N-terminal motifs of RNase H domain to generate p54, p57, p60, and p63 derivatives...
June 19, 2017: Biochemistry
https://www.readbyqxmd.com/read/28621331/corrigendum-hepatic-p63-regulates-steatosis-via-ikk%C3%AE-er-stress
#12
Begoña Porteiro, Marcos F Fondevila, Teresa C Delgado, Cristina Iglesias, Monica Imbernon, Paula Iruzubieta, Javier Crespo, Amaia Zabala-Letona, Johan Fernø, Bárbara González-Terán, Nuria Matesanz, Lourdes Hernández-Cosido, Miguel Marcos, Sulay Tovar, Anxo Vidal, Julia Sánchez-Ceinos, Maria M Malagon, Celia Pombo, Juan Zalvide, Arkaitz Carracedo, Xabier Buque, Carlos Dieguez, Guadalupe Sabio, Miguel López, Patricia Aspichueta, María L Martínez-Chantar, Ruben Nogueiras
This corrects the article DOI: 10.1038/ncomms15111.
June 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28616902/-expression-of-ttf-1-napsina-p63-ck5-6-in-lung-cancer-and-its-diagnostic-values-for-histological-classification
#13
He Yu, Lei Li, Dan Liu, Wei-Min Li
OBJECTIVES: To investigate the expressions of thyroid transcription factor-1(TTF-1), NapsinA, P63 and CK5/6 in lung cancer tissues and their diagnostic value for histological classification. METHODS: The protein expression in a total of 964 lung cancer samples was detected by immunohistochemistry, of which 929 cases for TTF-1, 113 cases for NapsinA, 282 cases for P63, and 277 for CK5/6, respectively. The correlations between the protein expressions of the four markers and clinicopathological features in lung cancer patients were analyzed...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28616595/a-rare-case-of-anal-carcinosarcoma-with-human-papilloma-virus-infection-in-both-biphasic-tumor-elements-an-immunohistochemical-molecular-and-ultrastructural-study
#14
Richard A Hickman, Azore-Dee Bradshaw, Nicholas Cassai, Antonio Galvao Neto, David Zhou, Tinghao Fu, Peng Lee, Zhiheng Pei, Rosemary Wieczorek
Carcinosarcoma of the anus is rare and has yet to be reportedly associated with the keratinocyte-specific Human Papilloma Virus (HPV). We describe a case of anal carcinosarcoma with HPV infection in both the epithelial and mesenchymal components of the tumor by immunohistochemistry, chromogenic in-situ hybridization (CISH) and further supported by electron microscopy (EM). Microscopic examination of the tumor showed nests of poorly-differentiated invasive squamous cell carcinoma with basaloid features intermixed with a hypercellular, atypical spindle cell proliferation...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/28604879/natural-occurrence-of-the-diamond-hexagonal-structure-in-silicon-nanowires-grown-by-a-plasma-assisted-vapour-liquid-solid-method
#15
J Tang, J-L Maurice, F Fossard, I Florea, W Chen, E V Johnson, M Foldyna, L Yu, P Roca I Cabarrocas
Silicon nanowires have been grown by a plasma-assisted vapour-liquid-solid method using tin as the catalyst. Transmission electron microscopy in the [12[combining macron]10] zone axis shows that the diamond hexagonal (P63/mmc) crystal structure is present in several nanowires. This is the first unambiguous proof of the natural occurrence of this metastable phase to our knowledge.
June 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28604778/p63-exerts-spatio-temporal-control-of-palatal-epithelial-cell-fate-to-prevent-cleft-palate
#16
Rose Richardson, Karen Mitchell, Nigel L Hammond, Maria Rosaria Mollo, Evelyn N Kouwenhoven, Niki D Wyatt, Ian J Donaldson, Leo Zeef, Tim Burgis, Rognvald Blance, Simon J van Heeringen, Hendrik G Stunnenberg, Huiqing Zhou, Caterina Missero, Rose Anne Romano, Satrajit Sinha, Michael J Dixon, Jill Dixon
Cleft palate is a common congenital disorder that affects up to 1 in 2500 live births and results in considerable morbidity to affected individuals and their families. The aetiology of cleft palate is complex with both genetic and environmental factors implicated. Mutations in the transcription factor p63 are one of the major individual causes of cleft palate; however, the gene regulatory networks in which p63 functions remain only partially characterized. Our findings demonstrate that p63 functions as an essential regulatory molecule in the spatio-temporal control of palatal epithelial cell fate to ensure appropriate fusion of the palatal shelves...
June 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28595999/p63-transcription-factor-regulates-nuclear-shape-and-expression-of-nuclear-envelope-associated-genes-in-epidermal-keratinocytes
#17
Valentina Rapisarda, Igor Malashchuk, Inemo E Asamaowei, Krzysztof Poterlowicz, Michael Y Fessing, Andrey A Sharov, Iakowos Karakesisoglou, Vladimir A Botchkarev, Andrei Mardaryev
The maintenance of a proper nuclear architecture and 3D organization of the genes, enhancer elements and transcription machinery plays an essential role in tissue development and regeneration. Here we show that in the developing skin, epidermal progenitor cells of mice lacking p63 transcription factor display alterations in the nuclear shape accompanied by marked decrease in expression of several nuclear envelop-associated components (Lamin B1, Lamin A/C, SUN1, Nesprin-3, Plectin) compared to controls. Furthermore, ChIP-qPCR assay showed enrichment of p63 on Sun1, Syne3 and Plec promoters, suggesting them as p63 targets...
June 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28595997/hpv8-field-cancerization-in-a-transgenic-mouse-model-is-due-to-lrig1-keratinocyte-stem-cell-expansion
#18
Simone Lanfredini, Carlotta Olivero, Cinzia Borgogna, Federica Calati, Kathryn Powell, Kelli-Jo Davies, Marco De Andrea, Sarah Harries, Hiu Kwan Carolyn Tang, Herbert Pfister, Marisa Gariglio, Girish K Patel
β-HPV cause near ubiquitous latent skin infection within long-lived hair follicle keratinocyte stem cells (HF KSC). In patients with epidermodysplasia verruciformis (EV), β-HPV viral replication is associated with skin keratosis and cutaneous squamous cell carcinoma (SCC). To determine the role of HF KSC in β-HPV induced skin carcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter drives expression of the entire HPV8 early region (HPV8tg). HPV8tg mice developed thicker skin in comparison to wild type littermates consistent with a hyperproliferative epidermis...
June 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28593937/basaloid-squamous-cell-carcinoma-of-the-head-and-neck-subclassification-into-basal-ductal-and-mixed-subtypes-based-on-comparison-of-clinico-pathologic-features-and-expression-of-p53-cyclin-d1-epidermal-growth-factor-receptor-p16-and-human-papillomavirus
#19
Kyung-Ja Cho, Se-Un Jeong, Sung Bae Kim, Sang-Wook Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
Background: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has been suggested to originate from a totipotent primitive cell in the basal cell layer of the surface epithelium or in the proximal duct of secretory glands. Materials and Methods: Twenty-six cases of head and neck BSCC from Asan Medical Center, Seoul, Korea, reported during a 14-year-period were subclassified into basal, ductal, and mixed subtypes according to the expression of basal (cytokeratin [CK] 5/6, p63) or ductal markers (CK7, CK8/18)...
June 8, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28590468/the-influence-of-cation-ordering-oxygen-vacancy-distribution-and-proton-siting-on-observed-properties-in-ceramic-electrolytes-the-case-of-scandium-substituted-barium-titanate
#20
Nico Torino, Paul F Henry, Christopher S Knee, Tor Svendsen Bjørheim, Seikh M H Rahman, Emma Suard, Carlotta Giacobbe, Sten G Eriksson
The origin of the 2-order of magnitude difference in the proton conductivity of the hydrated forms of hexagonal and cubic oxygen deficient BaScxTi1-xO3-δ (x = 0.2 and x = 0.7) was probed using a combination of neutron diffraction and density functional theory techniques to support published X-ray diffraction, conductivity, thermogravimetric and differential scanning calorimetry studies. Cation ordering is found in the 6H structure type (space group P63/mmc) adopted by BaSc0.2Ti0.8O3-δ with scandium preferentially substituting in the vertex sharing octahedra (2a crystallographic site) and avoiding the face-sharing octahedra (4f site)...
June 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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