keyword
https://read.qxmd.com/read/38536955/highly-contorted-rigid-nitrogen-rich-nanographene-with-four-heptagons
#21
JOURNAL ARTICLE
Abdusalom A Suleymanov, Qilin He, Peter Müller, Timothy M Swager
Nucleophilic substitution of 9,10-dichlorooctafluoroanthracene with 3,4-diethylpyrrole and subsequent Scholl reaction give the annularly fused decapyrrollyl anthracene. Single crystal X-ray analysis revealed a highly contorted geometry induced by a combination of adjacent heptagons, forming a unique 7-7-6-7-7 topology. The end-to-end twist angle along the acene moiety is 90°. Cyclic voltammetry studies reveal 6-electron oxidation waves. Density functional theory calculations provided further insights into the aromaticity and electronic properties of this highly twisted, nitrogen-rich nanographene...
March 27, 2024: Organic Letters
https://read.qxmd.com/read/38536919/iterative-assay-for-transposase-accessible-chromatin-by-sequencing-to-isolate-functionally-relevant-neuronal-subtypes
#22
JOURNAL ARTICLE
Collin B Merrill, Iris Titos, Miguel A Pabon, Austin B Montgomery, Aylin R Rodan, Adrian Rothenfluh
The Drosophila brain contains tens of thousands of distinct cell types. Thousands of different transgenic lines reproducibly target specific neuron subsets, yet most still express in several cell types. Furthermore, most lines were developed without a priori knowledge of where the transgenes would be expressed. To aid in the development of cell type-specific tools for neuronal identification and manipulation, we developed an iterative assay for transposase-accessible chromatin (ATAC) approach. Open chromatin regions (OCRs) enriched in neurons, compared to whole bodies, drove transgene expression preferentially in subsets of neurons...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536900/optimized-bags-of-artificial-neural-networks-can-predict-the-viability-of-organisms-exposed-to-nanoparticles
#23
JOURNAL ARTICLE
Ravithree D Senanayake, Clyde A Daly, Rigoberto Hernandez
Prediction of organismal viability upon exposure to a nanoparticle in varying environments─as fully specified at the molecular scale─has emerged as a useful figure of merit in the design of engineered nanoparticles. We build on our earlier finding that a bag of artificial neural networks (ANNs) can provide such a prediction when such machines are trained with a relatively small data set (with ca. 200 examples). Therein, viabilities were predicted by consensus using the weighted means of the predictions from the bags...
March 27, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38536882/palladium-catalyzed-regioselective-insertion-of-carbenes-into-%C3%AE-c-sp-3-h-bonds-of-aliphatic-amines
#24
JOURNAL ARTICLE
Peng Zhang, Cheng-Xin Li, ShihaoZhi Wang, Xue-Jing Zhang, Ming Yan
A migratory insertion of carbenes into distal γ-C(sp3 )-H bonds of aliphatic amines has been successfully developed. The synergistic interplay among a palladium catalyst, picolinamide directing group, a carefully selected base additive, and an essential ligand proved crucial in achieving high yields. These findings hold significant value for advancing the exploration of regioselective carbene insertions into nonactivated C(sp3 )-H bonds.
March 27, 2024: Organic Letters
https://read.qxmd.com/read/38536868/the-social-determinants-of-migrant-domestic-worker-mdw-health-and-well-being-in-the-western-pacific-region-a-scoping-review
#25
JOURNAL ARTICLE
Jamie Chan, Georgia Dominguez, Antonia Hua, Melissa Garabiles, Carl A Latkin, Brian J Hall
The health and well-being of transnational migrant domestic workers (MDWs) is a pressing but largely neglected public health concern. The Asia Pacific region is home to over 20% of the global MDW population. Living and working conditions, social contexts, political environments, and migration regimes are recognized as consequential to the health of this population, but currently no synthesis of available literature to prioritize research or policy agenda setting for MDW has yet been conducted. This scoping review screened 6,006 peer-reviewed articles and 1,217 gray literature sources, identifying 173 articles and 276 gray literature sources that reported key MDW health outcomes, social determinants of health, and related interventions...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#26
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38536858/dynamics-of-leaching-of-pops-and-additives-from-plastic-in-a-procellariiform-gastric-model-diet-and-polymer-dependent-effects-and-implications-for-long-term-exposure
#27
JOURNAL ARTICLE
Liesbeth Van Hassel, Georges Scholl, Gauthier Eppe, Claude Poleunisc, Christine Dupont-Gillain, Myra Finkelstein, Cathy Debier
Procellariiform seabirds are known to have high rates of plastic ingestion. We investigated the bioaccessibility of plastic-associated chemicals [plastic additives and sorbed persistent organic pollutants (POPs)] leached from plastic over time using an in vitro Procellariiform gastric model. High-density polyethylene (HDPE) and polyvinyl chloride (PVC), commonly ingested by Procellariiform seabirds, were manufactured with one additive [decabrominated diphenyl ether (PBDE-209) or bisphenol S (BPS)]. HDPE and PVC added with PBDE-209 were additionally incubated in salt water with 2,4,4'-trichloro-1,1'-biphenyl (PCB-28) and 2,2',3,4,4',5'-hexachlorobiphenyl (PCB-138) to simulate sorption of POPs on plastic in the marine environment...
2024: PloS One
https://read.qxmd.com/read/38536856/factors-associated-with-the-uptake-of-intermittent-preventive-treatment-for-malaria-during-pregnancy-in-cameroon-an-analysis-of-data-from-the-2018-cameroon-demographic-and-health-survey
#28
JOURNAL ARTICLE
Dominique Ken Guimsop, Ange Faustine Kenmogne Talla, Haoua Kodji, Jerome Ateudjieu
Malaria in pregnancy is a major public health concern that contributes to a significant increase in maternal and child mortality and morbidity. Intermittent preventive treatment of malaria during pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) is a key intervention recommended by the World Health Organization (WHO) and implemented in Cameroon to reduce the morbidity associated with malaria during pregnancy. This study aimed to assess the distribution of the poor uptake of IPTp-SP (i.e. fewer than three doses) in Cameroon and the factors associated...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536836/effects-of-primary-health-care-and-socioeconomic-aspects-on-the-dispersion-of-covid-19-in-the-brazilian-northeast-ecological-study-of-the-first-pandemic-wave
#29
JOURNAL ARTICLE
Luana Resende Cangussú, Jeisyane Acsa Santos Do Nascimento, Igor Rafael Pereira de Barros, Rafael Limeira Cavalcanti, Fábio Galvão Dantas, Diego Neves Araujo, José Felipe Costa da Silva, Thais Sousa Rodrigues Guedes, Matheus Rodrigues Lopes, Johnnatas Mikael Lopes, Marcello Barbosa Otoni Gonçalves Guedes
BACKGROUND: The COVID-19 pandemic has had a negative impact on socioeconomic and public health conditions of the population. AIM: To measure the temporal evolution of COVID-19 cases in cities near the countryside outside metropolitan areas of northeastern Brazil and the impact of the primary care organization in its containment. METHODS: This is a time-series study, based on the first three months of COVID-19 incidence in northeastern Brazil...
2024: PloS One
https://read.qxmd.com/read/38536832/rapid-resurgence-of-syphilis-in-japan-after-the-covid-19-pandemic-a-descriptive-study
#30
JOURNAL ARTICLE
Akira Komori, Hirotake Mori, Wenke Xie, Simon Valenti, Toshio Naito
Some countries have reported a post-pandemic resurgence in syphilis prevalence, but trend data in the World Health Organization Western Pacific Region (WHO-WPRO), including Japan, are severely lacking. Thus, the present study compares the number of syphilis cases before and after the COVID-19 pandemic in some WHO-WPRO countries. In addition, temporal trends in the number of syphilis cases in Japan pre- and post-pandemic are described. Annual numbers of syphilis cases during the study periods from China, New Zealand, Australia and Japan were compared...
2024: PloS One
https://read.qxmd.com/read/38536829/the-effects-of-gases-from-food-waste-on-human-health-a-systematic-review
#31
JOURNAL ARTICLE
Paulina Rudziak, Evans Batung, Isaac Luginaah
Food waste is a routine and increasingly growing global concern that has drawn significant attention from policymakers, climate change activists and health practitioners. Amid the plurality of discourses on food waste-health linkages, however, the health risks from food waste induced emissions have remained under explored. This lack of evidence is partly because of the lack of complete understanding of the effects of food waste emissions from household food waste on human health either directly through physiological mechanisms or indirectly through environmental exposure effects...
2024: PloS One
https://read.qxmd.com/read/38536824/copayment-mechanism-in-selected-districts-of-uganda-availability-market-share-and-price-of-quality-assured-artemisinin-based-combination-therapies-in-private-drug-outlets
#32
JOURNAL ARTICLE
Moses Ocan, Winnie Nambatya, Caroline Otike, Loyce Nakalembe, Sam Nsobya
BACKGROUND: Malaria remains one of the leading causes of morbidity, and mortality in Uganda. A large proportion of malaria symptomatic patients seek healthcare in private sector. However, availability and affordability are major barriers to access to effective treatment. The private sector copayment mechanism in Uganda aims to increase availability and affordability of antimalarial agents. Our study assessed availability, price, and market share of quality assured artemisinin-based combination therapies (QAACTs) in private drug outlets in selected districts during the implementation of copayment mechanism...
2024: PloS One
https://read.qxmd.com/read/38536819/stem-cell-derived-vessels-on-chip-for-cardiovascular-disease-modeling
#33
JOURNAL ARTICLE
Maren Marder, Caroline Remmert, Julius A Perschel, Munkhtur Otgonbayar, Christine von Toerne, Stefanie Hauck, Judith Bushe, Annette Feuchtinger, Bilal Sheikh, Michel Moussus, Matthias Meier
The metabolic syndrome is accompanied by vascular complications. Human in vitro disease models are hence required to better understand vascular dysfunctions and guide clinical therapies. Here, we engineered an open microfluidic vessel-on-chip platform that integrates human pluripotent stem cell-derived endothelial cells (SC-ECs). The open microfluidic design enables seamless integration with state-of-the-art analytical technologies, including single-cell RNA sequencing, proteomics by mass spectrometry, and high-resolution imaging...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536817/rpgr-is-a-guanine-nucleotide-exchange-factor-for-the-small-gtpase-rab37-required-for-retinal-function-via-autophagy-regulation
#34
JOURNAL ARTICLE
Ruhong Ying, Cong Li, Huirong Li, Juan Zou, Mengxin Hu, Qiang Hong, Yin Shen, Ling Hou, Hanhua Cheng, Rongjia Zhou
Although the small GTPase RAB37 acts as an organizer of autophagosome biogenesis, the upstream regulatory mechanism of autophagy via guanosine diphosphate (GDP)-guanosine triphosphate (GTP) exchange in maintaining retinal function has not been determined. We found that retinitis pigmentosa GTPase regulator (RPGR) is a guanine nucleotide exchange factor that activates RAB37 by accelerating GDP-to-GTP exchange. RPGR directly interacts with RAB37 via the RPGR-RCC1-like domain to promote autophagy through stimulating exchange...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536795/why-do-people-sell-their-kidneys-a-thematic-synthesis-of-qualitative-evidence
#35
JOURNAL ARTICLE
Bijaya Shrestha, Luechai Sringernyuang, Manash Shrestha, Binita Shrestha, Anuska Adhikari, Dev Ram Sunuwar, Shiva Raj Mishra, Bipin Adhikari
Globally, demands for the kidneys have surpassed supply both living and deceased donors. High demands relative to the availability have made the kidney one of the most saleable human organs. The main objective was to explore the drivers of kidney selling. Literature related to kidney selling and its drivers was explored in three databases including MEDLINE (PubMed), Scopus (Elsevier), and JSTOR covering the period from 1987 to 2022. A total of 15 articles were selected, which underwent thematic analysis. Investigators independently assessed the articles for relevance and study quality to synthesize the data...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536734/are-day-flying-moths-more-specialised-in-larval-dietary-breadth-a-test-of-the-salient-aroma-hypothesis-in-a-predominantly-nocturnal-clade
#36
JOURNAL ARTICLE
Carlo L Seifert, Patrick Strutzenberger, Konrad Fiedler
Although diurnality is widespread across Lepidoptera and has evolved many times independently, its causes and ecological implications are yet poorly understood. The 'Salient Aroma Hypothesis' (SAH) postulates that diurnal insect herbivores are overall more specialised in dietary breadth than species active at night. It is furthermore assumed that diurnality evolved more frequently in species that live in cooler environments. Using European geometrid moths as a model group, we tested whether diurnal activity in adults is associated with an increased larval dietary breadth as predicted by the 'Salient Aroma Hypothesis...
March 27, 2024: Evolution; International Journal of Organic Evolution
https://read.qxmd.com/read/38536713/incl-3-tfoh-mediated-convenient-synthesis-of-3-alkylideneoxindoles-from-2-oxindoles-with-1-3-diones-ketones-or-aldehydes
#37
JOURNAL ARTICLE
Xia Chen, Xiao-Yu Zhou, Hai-Long Liu, Chao Ding, Jin-Hui Li
Two efficient and convenient methods for the synthesis of 3-alkylideneoxindoles are described in this paper. The InCl3 /TfOH-mediated tandem Knoevenagel condensation-deacylation sequence of various 2-oxindoles with 1,3-diones or acetoacetate furnished 3-alkylideneoxindoles in satisfactory to excellent yields (up to >99% yield). Employing the reaction system, the condensation of 2-oxindoles with ketones or aldehydes also proceeded smoothly to produce 3-alkylideneoxindoles. This protocol can be amenable to scale up...
March 27, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38536672/visible-light-induced-radical-addition-elimination-reaction-for-constructing-allylic-sulfones-from-sulfonyl-chlorides-and-allyl-bromides
#38
JOURNAL ARTICLE
Rui-Xue Li, Yuan Chen, Lan-Qian Huang, Zhi Guan, Yan-Hong He
Allyl sulfones are commonly present in bioactive compounds and organic building blocks. This work introduces a photocatalytic radical addition-elimination reaction involving readily accessible sulfonyl chlorides and allyl bromides. It delivers structurally diverse allylic sulfones in moderate to excellent yields, showcasing a high tolerance to functional groups. Notably, this method operates under mild reaction conditions without the need for oxidants, stoichiometric reducing metals, or additives.
March 27, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38536667/high-temperature-electron-diffraction-on-organic-crystals-in-situ-crystal-structure-determination-of-pigment-orange-34
#39
JOURNAL ARTICLE
Yaşar Krysiak, Sergi Plana-Ruiz, Lothar Fink, Edith Alig, Ulrich Bahnmüller, Ute Kolb, Martin U Schmidt
Small molecule structures and their applications rely on good knowledge of their atomic arrangements. However, the crystal structures of these compounds and materials, which are often composed of fine crystalline domains, cannot be determined with single-crystal X-ray diffraction. Three-dimensional electron diffraction (3D ED) is already becoming a reliable method for the structure analysis of submicrometer-sized organic materials. The reduction of electron beam damage is essential for successful structure determination and often prevents the analysis of organic materials at room temperature, not to mention high temperature studies...
March 27, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38536646/impact-of-immunosuppressed-status-on-prognosis-of-carbapenem-resistant-organisms-bloodstream-infections
#40
JOURNAL ARTICLE
Yuan-Yuan Li, Yan Chen, Shan Li, Yuan-Yuan Li, Ran An, Xiao-Yun Hu, Wei Jiang, Chun-Yao Wang, Run Dong, Qi-Wen Yang, Li Weng, Jin-Min Peng, Bin Du
INTRODUCTION: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients. METHODS: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients...
March 27, 2024: Infectious Diseases and Therapy
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