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https://www.readbyqxmd.com/read/28743155/neoadjuvant-chemotherapy-prior-to-radical-cystectomy-for-muscle-invasive-bladder-cancer-with-variant-histology
#1
Malte W Vetterlein, Stephanie A M Wankowicz, Thomas Seisen, Richard Lander, Björn Löppenberg, Felix K-H Chun, Mani Menon, Maxine Sun, Justine A Barletta, Toni K Choueiri, Joaquim Bellmunt, Quoc-Dien Trinh, Mark A Preston
BACKGROUND: Neoadjuvant chemotherapy in pure urothelial bladder cancer provides a significant survival benefit. However, to the authors' knowledge, it is unknown whether this benefit persists in histological variants. The objective of the current study was to assess the effect of neoadjuvant chemotherapy on the probability of non-organ-confined disease and overall survival after radical cystectomy (RC) in patients with histological variants. METHODS: Querying the National Cancer Data Base, the authors identified 2018 patients with histological variants who were undergoing RC for bladder cancer between 2003 and 2012...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28743148/-impact-of-cardiac-anaesthesia-on-patient-outcome
#2
Martina Nowak-Machen
The perioperative management of complex patients in a highly technical and subspecialized environment is the domain of the cardiac anesthesiologist. Evidence suggests that hemodynamic management using goal directed hemodynamic therapy (GDHT) improves patient outcome. Organ protection remains a main concern during cardiac surgery using extracorporeal circulation. Mortality can be decreased when remote ischemic preconditioning techniques (RIPC) are being used. Neurological outcomes can be improved with near-infrared-spectometry (NIRS), volatile anesthetics increase myocardial protection through preconditioning and perioperative echocardiography increases overall patient survival...
July 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28743138/-iso-9001-2015-certification-in-quality-management
#3
Christian Enders, Gabriele E Lang, Gerhard K Lang, Jens Ulrich Werner
Quality management improves the structures, processes and results of organizations of all kinds. Many practices and clinics have their existing quality management system certified according to ISO 9001, (e.g., to check their own quality management system or to obtain a testimonial against third parties). The latest version ISO 9001:2015 contains some changes, both structurally and in terms of content. These changes can be met with reasonable efforts. An ISO 9001:2015 certification represents a value for your organization, but these advantages are often not directly measurable...
July 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28743092/polycyclic-aromatic-hydrocarbons-pahs-enrich-their-degrading-genera-and-genes-in-human-impacted-aquatic-environments
#4
Ke Yuan, Baowei Chen, Qing Qing, Shichun Zou, Xiaowei Wang, Tiangang Luan
Bacterial degradation is an important clearance pathway for organic contaminants from highly human-impacted environments. However, it is not fully understood how organic contaminants are selected for degradation by bacteria and genes in aquatic environments. In this study, PAH degrading bacterial genera and PAH-degradation-related genes (PAHDGs) in sediments collected from the Pearl River (PR), the Pearl River Estuary (PRE) and the South China Sea (SCS), among which there were distinct differences in anthropogenic impact, were analyzed using metagenomic approaches...
July 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28743073/in-situ-biodegradation-potential-of-1-2-dca-and-vc-at-sites-with-different-hydrogeological-settings
#5
R C M Nobre, M M M Nobre, T M P Campos, D Ogles
This paper investigates the feasibility of applying in-situ Bioremediation (ISB) to three sites contaminated with vinyl chloride and/or chlorinated alkanes such as 1,2-DCA and 1,1,2-TCA, presenting distinct hydrogeological settings and history of contaminant loading. Biotransformation of these compounds is well established in laboratory studies and pure cultures. Due to confidential aspects, however, few field data are available to support real case studies to the predictability of their fate and lifetime in soil and groundwater...
July 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28743072/molecular-modeling-and-molecular-dynamics-simulation-study-of-archaeal-leucyl-trna-synthetase-in-complex-with-different-mischarged-trna-in-editing-conformation
#6
A V Rayevsky, M Sharifi, M A Tukalo
Aminoacyl-tRNA synthetases (aaRSs) play important roles in maintaining the accuracy of protein synthesis. Some aaRSs accomplish this via editing mechanisms, among which leucyl-tRNA synthetase (LeuRS) edits non-cognate amino acid norvaline mainly by post-transfer editing. However, the molecular basis for this pathway for eukaryotic and archaeal LeuRS remain unclear. In this study, a complex of archaeal P. horikoshii LeuRS (PhLeuRS) with misacylated tRNA(Leu) was modeled wherever tRNA's acceptor stem was oriented directly into the editing site...
July 18, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28743065/enantiomerization-and-stereoselectivity-in-bioaccumulation-of-furalaxyl-in-tenebrio-molitor-larvae
#7
Jing Yin, Yongxin Gao, Feilong Zhu, Weiyu Hao, Qi Xu, Huili Wang, Baoyuan Guo
Furalaxyl is a chiral pesticide and widely used in modern agriculture as racemate mixture. The enantiomerization and enantioselecive bioaccumulation by a single dose of furalaxyl to Tenebrio molitor larvae under laboratory conditions were studied using a high-performance liquid chromatography tandem mass spectroscopy method based on a ChiralPAK IC column. Our results showed that a significant enantiomerization (interconversion between R-enantiomer and S-enantiomer) was observed in Tenebrio molitor larvae under R- or S-furalaxyl exposure...
July 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28743042/clinical-outcome-and-rehabilitation-of-homeless-mentally-ill-patients-admitted-in-mental-health-institute-of-south-india-know-the-unknown-project
#8
Guru S Gowda, G Gopika, Channaveerachari Naveen Kumar, Narayana Manjunatha, Ravi Yadav, Dwarakanath Srinivas, Bharath Rose Dawn, Suresh Bada Math
OBJECTIVES: Homeless Mentally Ill (HMI) patients represent a unique global problem and pose a challenge in treatment, management and rehabilitation services. There is sparse data on HMI patients in India. The objective of this paper is to study the clinical outcome and rehabilitation of HMI patients. METHODS: We performed a retrospective chart review of 'HMI' patients from 1st January 2002 to 31st December 2015, who were admitted under Department of Psychiatry at National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India...
July 4, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28743034/therapeutic-advances-in-musculoskeletal-aav-targeting-approaches
#9
REVIEW
Karen Bulaklak, Xiao Xiao
The use of recombinant adeno-associated viruses (rAAVs) is highly prevalent in musculoskeletal gene therapies due to their versatility, high transduction efficiency, natural tropism and vector genome persistence for years. As the largest organ in the body, treatment of skeletal muscle for widespread and sufficient therapeutic gene expression is highly challenging. In addition to disease-specific hurdles, vector genome loss, off-target gene transfer and immune responses to treatment can diminish the overall benefit of rAAV therapies...
July 22, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28743008/wastewater-contamination-in-antarctic-melt-water-streams-evidenced-by-virological-and-organic-molecular-markers
#10
L F L Tort, K Iglesias, C Bueno, A Lizasoain, M Salvo, J Cristina, N Kandratavicius, L Pérez, R Figueira, M C Bícego, S Taniguchi, N Venturini, E Brugnoli, R Colina, M Victoria
Human activities in the Antarctica including tourism and scientific research have been raised substantially in the last century with the concomitant impact on the Antarctic ecosystems through the release of wastewater mainly from different scientific stations activities. The aim of this study was to assess the wastewater contamination of surface waters and sediments of three melt-water streams (11 sites) by leaking septic tanks located in the vicinity of the Uruguayan Scientific Station in the Fildes Peninsula, King George Island, Antarctica, during summer 2015...
July 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28743007/environmental-footprints-of-brick-kiln-bottom-ashes-geostatistical-approach-for-assessment-of-metal-toxicity
#11
Ananya Mondal, Subhasish Das, Rajesh Kumar Sah, Pradip Bhattacharyya, Satya Sundar Bhattacharya
Coal fired brick kiln factories generate significant of brick kiln bottom ash (BKBA) that contaminate soil and water environments of areas near the dumping sites through leaching of toxic metals (Pb, Cr, Cd, Zn, Mn, and Cu). However, characteristics and environmental effects of BKBAs are yet unknown. We collected BKBA samples from 32 strategic locations of two rapidly developing States (West Bengal and Assam) of India. Scanning electron microscope images indicated spherical and granular structures of BKBAs produced in West Bengal (WBKBA) and Assam (ABKBA) respectively; while energy dispersive spectroscopy and analytical assessments confirmed substantial occurrence of total organic C and nutrient elements (N, P, K, Ca, Mg, and S) in both the BKBAs...
July 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28743003/patterned-disordered-cell-motion-ensures-vertebral-column-symmetry
#12
Dipjyoti Das, Veena Chatti, Thierry Emonet, Scott A Holley
The biomechanics of posterior embryonic growth must be dynamically regulated to ensure bilateral symmetry of the spinal column. Throughout vertebrate trunk elongation, motile mesodermal progenitors undergo an order-to-disorder transition via an epithelial-to-mesenchymal transition and sort symmetrically into the left and right paraxial mesoderm. We combine theoretical modeling of cell migration in a tail-bud-like geometry with experimental data analysis to assess the importance of ordered and disordered cell motion...
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28743002/drosophila-histone-demethylase-kdm4a-has-enzymatic-and-non-enzymatic-roles-in-controlling-heterochromatin-integrity
#13
Serafin U Colmenares, Joel M Swenson, Sasha A Langley, Cameron Kennedy, Sylvain V Costes, Gary H Karpen
Eukaryotic genomes are broadly divided between gene-rich euchromatin and the highly repetitive heterochromatin domain, which is enriched for proteins critical for genome stability and transcriptional silencing. This study shows that Drosophila KDM4A (dKDM4A), previously characterized as a euchromatic histone H3 K36 demethylase and transcriptional regulator, predominantly localizes to heterochromatin and regulates heterochromatin position-effect variegation (PEV), organization of repetitive DNAs, and DNA repair...
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28742989/agricultural-leaders-influence-on-the-safety-culture-of-workers
#14
Frank A Gasperini
Most US farmers are small, independent owner-operators, many of whom are exempt from safety regulation and enforcement, as well as age restrictions relative to family members performing hazardous tasks. These smaller farms account for a disproportionate share of the total fatality and injury statistics from farming incidents, contributing to an agriculture-industry death rate that is seven times greater than all occupations combined. In contrast, large agricultural enterprises that employ larger numbers of non-family workers are more regulated and more highly incentivized by economic, supply chain, and societal factors to implement cultures of safety, and are more readily influenced by agricultural opinion leaders, agribusinesses, farm organizations, and agricultural media...
July 25, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28742986/adsorption-of-mesitylene-via-mesoporous-adsorbents
#15
Kai Chun Nien, Feng Tang Chang, Moo Been Chang
Mesitylene (or 1,3,5-trimethylbenzene) is a volatile organic compound emitted from various industrial processes, e.g., spray coating. Its emissions have become a critical issue because mesitylene is toxic and cannot be removed using traditional adsorbents, e.g., zeolite (H-ZSM-5; the diameter of mesitylene molecules is greater than the pore size of H-ZSM-5). Hence, an adsorbent with a large pore size, MCM-41, is used in this study to investigate its adsorption capacity for mesitylene and is compared with that of H-ZSM-5...
July 25, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28742981/increased-precipitation-accelerates-soil-organic-matter-turnover-associated-with-microbial-community-composition-in-topsoil-of-the-alpine-grassland-on-the-eastern-tibetan-plateau
#16
Conghai Han, Zongli Wang, Guicai Si, Tianzhu Lei, Yanli Yuan, Gengxin Zhang
Large quantities of carbon are stored in the alpine grassland of the Tibetan Plateau (TP), where is extremely sensitive to climate change. However, it remains unclear whether soil organic matter (SOM) in different layers responds to climate change analogously, and whether microbial communities play vital roles in SOM turnover of topsoil. In this study we measured and collected SOM turnover by <sup>14</sup>C method in the alpine grassland to test climatic effects on SOM turnover in soil profiles...
July 25, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28742973/role-of-vitamin-a-oral-supplementation-on-oxidative-stress-and-inflammatory-response-in-the-liver-of-trained-rats
#17
Lyvia Lintzmaier Petiz, Alice Kunzler, Rafael Calixto Bortolin, Juciano Gasparotto, Cristiane Matté, José Claudio Fonseca Moreira, Daniel Pens Gelain
The use of dietary supplements to enhance the benefit of exercise training is a common practice. The liver is the organ where all substances are metabolized, and certain supplements have been associated with liver injury. Vitamin A (VA), a liposoluble vitamin stored in the liver, is commonly used as an antioxidant supplement. Here, we evaluated the effect of chronic VA supplementation on oxidative damage and stress parameters in trained rats. Animals were divided into the following groups: sedentary (SE), sedentary/VA (SE+VA), exercise training (ET), and exercise training/VA (ET+VA)...
July 25, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28742965/sequential-tandem-addition-reactions-to-a-tungsten-trifluorotoluene-complex-a-versatile-method-for-the-preparation-of-highly-functionalized-trifluoromethylated-cyclohexenes
#18
Katy B Wilson, Jeffery T Myers, Hannah S Nedzbala, Logan A Combee, Michal Sabat, W Dean Harman
The effects of an electron-withdrawing group on the organic chemistry of an η2-bound benzene ring are explored using the complex TpW(NO)(PMe3)(η2-PhCF3). This trifluorotoluene complex was found to undergo a highly regio- and stereoselective 1,2-addition reaction involving protonation of an ortho carbon followed by addition of a carbon nucleophile. The resulting 1,3-diene complexes can undergo a second protonation and nucleophilic addition with a range of nucleophiles including hydrides, amines, cyanide, and protected enolates...
July 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28742962/characterization-of-intramolecular-interactions-of-cytochrome-c-using-hydrogen-deuterium-exchange-trapped-ion-mobility-spectrometry-mass-spectrometry-and-molecular-dynamics
#19
Juan Camilo Molano-Arevalo, Kevin Jeanne Dit Fouque, Khoa N Pham, Jaroslava Miksovska, Mark E Ridgeway, Melvin A Park, Francisco Fernandez-Lima
Globular proteins, such as cytochrome c (cyt c), display an organized native conformation, maintained by a hydrogen bond interaction network. In the present work, the structural interrogation of kinetically trapped intermediates of cyt c was performed by correlating the ion-neutral collision cross section (CCS) and charge state with the starting solution conditions and time after desolvation using collision induced activation (CIA), time resolved hydrogen/deuterium back exchange (HDX) and trapped ion mobility spectrometry - mass spectrometry (TIMS-MS)...
July 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28742961/solid-solid-phase-transitions-and-t-butyl-and-methyl-group-rotation-in-an-organic-solid-x-ray-diffractometry-differential-scanning-calorimetry-and-solid-state-1h-nuclear-spin-relaxation
#20
Peter A Beckmann, Andrew R McGhie, Arnold L Rheingold, Gilbert J Sloan, Steven T Szewczyk
Using solid state 1H nuclear magnetic resonance (NMR) spin-lattice relaxation experiments, we have investigated the effects of several solid-solid phase transitions on t-butyl group and methyl group rotation in solid 1,3,5-tri-t-butylbenzene. The goal is to relate the dynamics of the t-butyl groups and their constituent methyl groups to properties of the solid determined using single-crystal X-ray diffraction and differential scanning calorimetry (DSC). On cooling, the DSC experiments see a first-order, solid-solid phase transition at either 268 K or 155 K (but not both) depending on thermal history...
July 25, 2017: Journal of Physical Chemistry. A
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