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Global oncology

Laura Curr Beamer, Marcia Grant
PURPOSE: The purpose of this pilot study was to explore the relationship between skin-related quality of life (SR-QOL) and global quality of life (G-QOL) among women experiencing breast radiodermatitis, measure change in SR-QOL and G-QOL between the start and fifth week on radiotherapy, and examine the trend in SR-QOL and severity of radiodermatitis over time on treatment. METHODS: A descriptive longitudinal study using repeated measurements was implemented. Forty women undergoing whole breast 3-dimensional conformal radiotherapy at a comprehensive community cancer center completed the Dermatology Life Quality Index (DLQI) weekly and Quality of Life-Breast Cancer Patient Version at baseline before and at five weeks on radiotherapy...
April 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Ophira Ginsburg, Gilberto Lopes
No abstract text is available yet for this article.
March 2018: Journal of Global Oncology
Jessica M Scott, Tormod S Nilsen, Dipti Gupta, Lee W Jones
Cardio-oncology is an emerging discipline focused predominantly on the detection and management of cancer treatment-induced cardiac dysfunction (cardiotoxicity), which predisposes to development of overt heart failure or coronary artery disease. The direct adverse consequences, as well as those secondary to anticancer therapeutics, extend beyond the heart, however, to affect the entire cardiovascular-skeletal muscle axis (ie, whole-organism cardiovascular toxicity). The global nature of impairment creates a strong rationale for treatment strategies that augment or preserve global cardiovascular reserve capacity...
March 13, 2018: Circulation
Stephanie C Casey, Virginie Baylot, Dean W Felsher
The MYC proto-oncogene is a gene product that coordinates the transcriptional regulation of a multitude of genes that are essential to cellular programs required for normal as well as neoplastic cellular growth and proliferation, including cell cycle, self-renewal, survival, cell growth, metabolism, protein and ribosomal biogenesis, and differentiation. Here we propose that MYC regulates these programs in a manner that is coordinated with a global influence on the host immune response. MYC had been presumed to contribute to tumorigenesis through tumor cell intrinsic influences...
March 7, 2018: Blood
Ferenc Jakab
Numerous outstanding summarizing publications on the milestones of the rapid development of liver surgery in the twentieth century came to light around the year 2000, therefore in this summary only the newest principles and novelties of liver surgery after the second millennium are presented. Among the new principles, the newest indications, the bloodless surgery and the vascular exclusion of the liver, the "associating liver partition and portal vein occlusion for staged hepatectomy" (ALPPS) - as presently the fastest and most successful method for liver regeneration, and the "downsizing of tumors" treatment for the interest of resection of unresectable tumours are analyzed and evaluated...
March 2018: Orvosi Hetilap
Temidayo Fadelu, Lawrence N Shulman
No abstract text is available yet for this article.
February 27, 2018: Nature Reviews. Clinical Oncology
Georgi Tchernev
Globalisation, scientific and technical progress are the basis of numerous innovative therapies for oncologic and non-oncologic diseases. It is another matter how much and by whom they are desired, and whether they have to be applied. When and how often? Innovative approaches should go towards simplification, universal distribution and application while at the same time analysis between the potential initial investment and the achieved final result should be made. An illustrative example for this is the targeted therapy for melanoma with its low baseline criteria or basic rules for its surgical treatment...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Mónica Patricia Cala, María Teresa Agulló-Ortuño, Elena Prieto-García, Carolina González-Riano, Lucía Parrilla-Rubio, Coral Barbas, Carmen Vanesa Díaz-García, Antonia García, Cristina Pernaut, Jorge Adeva, María Carmen Riesco, Francisco Javier Rupérez, Jose Antonio Lopez-Martin
BACKGROUND: Cachexia is a metabolic syndrome that affects up to 50-80% of cancer patients. The pathophysiology is characterized by a variable combination of reduced food intake and abnormal metabolism, including systemic inflammation and negative protein and energy balance. Despite its high clinical significance, defined diagnostic criteria and established therapeutic strategies are lacking. The 'omics' technologies provide a global view of biological systems. We hypothesize that blood-based metabolomics might identify findings in cachectic patients that could provide clues to gain knowledge on its pathophysiology, and eventually postulate new therapeutic strategies...
February 20, 2018: Journal of Cachexia, Sarcopenia and Muscle
Gerald W Prager, Sofia Braga, Branislav Bystricky, Camilla Qvortrup, Carmen Criscitiello, Ece Esin, Gabe S Sonke, Guillem Argilés Martínez, Jean-Sebastian Frenel, Michalis Karamouzis, Michiel Strijbos, Ozan Yazici, Paolo Bossi, Susana Banerjee, Teresa Troiani, Alexandru Eniu, Fortunato Ciardiello, Josep Tabernero, Christoph C Zielinski, Paolo G Casali, Fatima Cardoso, Jean-Yves Douillard, Svetlana Jezdic, Keith McGregor, Gracemarie Bricalli, Malvika Vyas, André Ilbawi
The cancer burden is rising globally, exerting significant strain on populations and health systems at all income levels. In May 2017, world governments made a commitment to further invest in cancer control as a public health priority, passing the World Health Assembly Resolution 70.12 on cancer prevention and control within an integrated approach. In this manuscript, the 2016 European Society for Medical Oncology Leadership Generation Programme participants propose a strategic framework that is in line with the 2017 WHO Cancer Resolution and consistent with the principle of universal health coverage, which ensures access to optimal cancer care for all people because health is a basic human right...
2018: ESMO Open
Ariela L Marshall, Sarah Jenkins, Joseph Mikhael, Scott D Gitlin
Nonmalignant hematologic conditions are extremely prevalent and contribute significantly to the global burden of disease. The US health care system may soon face a shortage of specialists in nonmalignant hematology. We sought to identify factors that lead hematology-oncology fellows to pursue (or not to pursue) careers in nonmalignant hematology. Cross-sectional, web-based survey distributed to 149 graduates of a hematology-oncology fellowship program at a large academic medical center between 1998 and 2016...
February 27, 2018: Blood Advances
M Wesley Milks, Michael R Velez, Nishaki Mehta, Abiodun Ishola, Thomas Van Houten, Vedat O Yildiz, Raquel Reinbolt, Maryam Lustberg, Sakima A Smith, David A Orsinelli
The prediction of cancer therapeutics-related cardiac dysfunction (CTRCD) is an essential aspect of care for individuals who receive potentially cardiotoxic oncologic treatments. Certain clinical risk factors have been described for incident CTRCD, and measurement of left ventricular (LV) longitudinal strain by speckle tracking 2-dimensional echocardiography (2DE) is the best-validated myocardial mechanical imaging assessment to detect subtle changes in LV function during cancer treatment. However, the direct integration of clinical and imaging risk factors to predict CTRCD has not yet been extensively examined...
January 12, 2018: American Journal of Cardiology
Garyfallos Konstantinoudis, Christian Kreis, Roland A Ammann, Felix Niggli, Claudia E Kuehni, Ben D Spycher
PURPOSE: Childhood cancers are rare and little is known about their etiology. Potential risk factors include environmental exposures that might implicate spatial variation of cancer risk. Previous studies of spatial clustering have mainly focused on childhood leukemia. We investigated spatial clustering of different childhood cancers in Switzerland using exact geocodes of place of residence. METHODS: We included 6,034 cancer cases diagnosed at age 0-15 years during 1985-2015 from the Swiss Childhood Cancer Registry...
February 13, 2018: Cancer Causes & Control: CCC
Maryam Alehashem, Shadi Baniasadi
BACKGROUND: A great number of antineoplastic drugs (ANPDs) are used globally in cancer treatment. Due to their adverse health effects, occupational exposure to ANPDs is considered a potential health risk to health care workers. OBJECTIVE: The current study aimed to evaluate safe-handling practices of ANPDs, exposure controls, and adverse health implications for health care providers exposed to ANDPs. METHODS: Prevention measures, including engineering, administrative, and work practice controls, as well as personal protective equipment (PPE), were recorded daily through a questionnaire for six weeks...
2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
Tanuja Shet
There is a global mandate even in countries with low resources to improve the accuracy of testing biomarkers in breast cancer viz. oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2neu) given their critical impact in the management of patients. The steps taken include compulsory participation in an external quality assurance (EQA) programme, centralized testing, and regular performance audits for laboratories. This review addresses the status of ER/PR and HER2neu testing in India and possible reasons for the delay in development of guidelines and mandate for testing in the country...
October 2017: Indian Journal of Medical Research
Christopher C DeStephano, Anita H Chen, Michael Heckman, Nicolette T Chimato, Paulami Guha, Mariana Espinal, Tri A Dinh
OBJECTIVE: Demonstrate the process for establishing or refuting validity for the Limbs and Things hysterectomy model. DESIGN: Prospective study using Kane's framework for establishing validity (Canadian Task Force Classification: II-2). SETTING: Laparoscopic hysterectomy (TLH) assessments completed in the operating room (OR) and simulation at three academic medical centers. PARTICIPANTS: OB/GYN residents (n=26 post-graduate year 3-4), a gynecologic oncology fellow (post-graduate year 5), and a gynecology oncology attending...
February 9, 2018: Journal of Minimally Invasive Gynecology
Martina Imbimbo, Jean-Michel Maury, Marina Garassino, Nicolas Girard
The management of patients with mesothelioma and thymic malignancy requires continuous multidisciplinary expertise at any step of the disease. A dramatic improvement in our knowledge has occurred in the last few years, through the development of databases, translational research programs, and clinical trials. Access to innovative strategies represents a major challenge, as there is a lack of funding for clinical research in rare cancers and their rarity precludes the design of robust clinical trials that could lead to specific approval of drugs...
February 2, 2018: European Journal of Surgical Oncology
Eleanor Anderson Reid, Esayas Kebede Gudina, Nicola Ayers, Wondimagegnu Tigineh, Yoseph Mamo Azmera
BACKGROUND: Palliative care aims to reduce physical suffering and the emotional, spiritual, and psychosocial distress of life-limiting illness. Palliative care is a human right, yet there are vast disparities in its provision: of the 40 million people globally in need of palliative care, less than 10% receive it, largely in high-income countries. There is a particular paucity of data on palliative care needs across the spectrum of incurable disease in Ethiopia. OBJECTIVES: The aims of this research were to assess the overall burden of life-limiting illness, the costs associated with life-limiting illness, and barriers to accessing palliative care in Ethiopia...
February 9, 2018: Journal of Palliative Medicine
Giovanni E Cacciamani, Luis G Medina, Tania S Gill, Alec Mendelsohn, Fatima Husain, Lokesh Bhardwaj, Walter Artibani, Renè Sotelo, Inderbir S Gill
CONTEXT: During robotic partial nephrectomy (RPN), various techniques of hilar control have been described, including on-clamp, early unclamping, selective/super-selective clamping, and completely-unclamped RPN. OBJECTIVE: To evaluate the impact of various hilar control techniques on perioperative, functional, and oncological outcomes of RPN for tumors. EVIDENCE ACQUISITION: We conducted a systematic literature review and meta-analysis of all comparative studies on various hilar control techniques during RPN using PubMed, Scopus, and Web of Science according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement, and Methods and Guide for Effectiveness and Comparative Effectiveness Review of the Agency for Healthcare Research and Quality...
February 5, 2018: European Urology Focus
Stéphanie Bricq, Hiliwi Leake Kidane, Jorge Zavala-Bojorquez, Alexandra Oudot, Jean-Marc Vrigneaud, François Brunotte, Paul Michael Walker, Alexandre Cochet, Alain Lalande
PET images deliver functional data, whereas MRI images provide anatomical information. Merging the complementary information from these two modalities is helpful in oncology. Alignment of PET/MRI images requires the use of multi-modal registration methods. Most of existing PET/MRI registration methods have been developed for humans and few works have been performed for small animal images. We proposed an automatic tool allowing PET/MRI registration for pre-clinical study based on a two-level hierarchical approach...
February 7, 2018: Medical & Biological Engineering & Computing
George Boon-Bee Goh, James Weiquan Li, Pik-Eu Chang, Khuan-Yew Chow, Chee-Kiat Tan
Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers globally. With advances in therapy for chronic viral hepatitis, changing social circumstances, and increasing practice of HCC surveillance, the epidemiology of HCC is expected to change over time. We explored the temporal trends in HCC in Singapore, a multiethnic Asian country, over the last 3 decades. Patients with HCC were prospectively enrolled and stratified into two cohorts (C1, 1988-2002; C2, 2003-2016). Patient and tumor characteristics, management, and survival were compared between the two cohorts, and a survival census was performed on October 31, 2015...
August 2017: Hepatology Communications
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