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https://www.readbyqxmd.com/read/29321020/meta-analysis-of-human-gene-expression-in-response-to-mycobacterium-tuberculosis-infection-reveals-potential-therapeutic-targets
#1
Zhang Wang, Seda Arat, Michal Magid-Slav, James R Brown
BACKGROUND: With the global emergence of multi-drug resistant strains of Mycobacterium tuberculosis, new strategies to treat tuberculosis are urgently needed such as therapeutics targeting potential human host factors. RESULTS: Here we performed a statistical meta-analysis of human gene expression in response to both latent and active pulmonary tuberculosis infections from nine published datasets. We found 1655 genes that were significantly differentially expressed during active tuberculosis infection...
January 10, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29319398/sexual-health-issues-for-the-young-adult-with-cancer-an-international-symposium-held-during-the-first-global-adolescents-and-young-adults-cancer-congress-edinburgh-united-kingdom
#2
Laura Mitchell, Jeremy Lewin, Julia Dirks, Kate Wang, Seline Tam, Anne Katz, Beth McCann, Kirk Lo, Valerie Laurence, Christine Rousset-Jablonski, Abha A Gupta
Sexual health is an important consideration for young adults with cancer; however, oncology healthcare providers are often not equipped with strategies to approach these problems in a systematic way. To address this gap in adolescents and young adults (AYA) care, a one-day international Sexual Health Symposium was held before the Global AYA Cancer Congress (Edinburgh, December 2016). The goals of the symposium were to (1) provide a forum, where international AYA experts had the opportunity to share their knowledge regarding AYA sexual health and (2) develop a guideline for healthcare professionals to screen for and intervene on sexual health issues...
January 10, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29306921/building-a-high-quality-oncology-nursing-workforce-through-lifelong-learning-the-de-souza-model
#3
Mary Jane Esplen, Jiahui Wong, Esther Green, Joy Richards, Jane Li
AbstractCancer is one of the leading causes of death in the world. Along with increased new cases, cancer care has become increasingly complex due to advances in diagnostics and treatments, greater survival, and new models of palliative care. Nurses are a critical resource for cancer patients and their families. Their roles and responsibilities are expanding across the cancer care continuum, calling for specialized training and support. Formal education prepares nurses for entry level of practice, however, it does not provide the specialized competencies required for quality care of cancer patients...
January 5, 2018: International Journal of Nursing Education Scholarship
https://www.readbyqxmd.com/read/29297902/-la-combinazione-di-gemcitabina-e-oxaliplatino-gemox-nel-trattamento-del-carcinoma-pancreatico-in-fase-avanzata-di-malattia-le-notizie-sulla-mia-morte-sono-state-esagerate
#4
Jacopo Giuliani, Andrea Bonetti
Riassunto. L'analisi è stata condotta al fine di valutare l'effetto sia sulla sopravvivenza globale (OS) sia sulla sopravvivenza libera da progressione di malattia (PFS) della chemioterapia di combinazione in prima linea per il carcinoma pancreatico in fase avanzata di malattia. La presente analisi è limitata agli studi randomizzati controllati (RCT) di fase III. Successivamente è stata applicata la European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) agli RCT di fase III analizzati per ricavare uno score relativo all'entità del beneficio clinico ottenuto per ciascun RCT...
December 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29296953/technological-solutions-for-global-hematology-and-oncology
#5
Ami S Bhatt
No abstract text is available yet for this article.
February 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29280241/parental-cancer-characteristics-of-users-of-child-centred-counselling-versus-individual-psycho-oncological-treatment
#6
Laura Inhestern, Wiebke Geertz, Frank Schulz-Kindermann, Corinna Bergelt
OBJECTIVE: The aims of this study were to investigate the characteristics of users of a specific child-centred counselling service (COSIP) and to compare those to parents using an individual psycho-oncological treatment (PO). METHODS: We conducted a retrospective analysis on data of users of COSIP and users of PO. Database was the routine assessment (demographic and disease-related characteristics, GAD-7, PHQ-9, EORTC QLQ-C30 and current concerns) of an outpatient psycho-oncological clinic with additional child-centred counselling...
December 27, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29277662/nf-%C3%AE%C2%BAb-in-the-crosshairs-rethinking-an-old-riddle
#7
Jason Bennett, Daria Capece, Federica Begalli, Daniela Verzella, Daniel D'Andrea, Laura Tornatore, Guido Franzoso
Constitutive NF-κB signalling has been implicated in the pathogenesis of most human malignancies and virtually all non-malignant pathologies. Accordingly, the NF-κB pathway has been aggressively pursued as an attractive therapeutic target for drug discovery. However, the severe on-target toxicities associated with systemic NF-κB inhibition have thus far precluded the development of a clinically useful, NF-κB-targeting medicine as a way to treat patients with either oncological or non-oncological diseases...
December 22, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29275932/an-in-vitro-study-to-assess-the-feasibility-validity-and-precision-of-capturing-oncology-facial-defects-with-multimodal-image-fusion
#8
Rachael Y Jablonski, Cecilie A Osnes, Balvinder S Khambay, Brian R Nattress, Andrew J Keeling
AIM: Assess the feasibility, validity and precision of multimodal image fusion to capture oncology facial defects based on plaster casts. METHODS: Ten casts of oncology facial defects were acquired. To create gold standard models, a 3D volumetric scan of each cast was obtained with a cone beam computed tomography (CBCT) scanner (NewTomVG). This was converted into surface data using open-source medical segmentation software and cropped to produce a CBCT mask using an open-source system for editing meshes...
December 21, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29250835/em-algorithm-estimation-of-a-structural-equation-model-for-the-longitudinal-study-of-the-quality-of-life
#9
Antoine Barbieri, Myriam Tami, Xavier Bry, David Azria, Sophie Gourgou, Caroline Bascoul-Mollevi, Christian Lavergne
Health-related quality of life (HRQoL) data are measured via patient questionnaires, completed by the patients themselves at different time points. We focused on oncology data gathered through the use of European Organization for Research and Treatment of Cancer questionnaires, which decompose HRQoL into several functional dimensions, several symptomatic dimensions, and the global health status (GHS). We aimed to perform a global analysis of HRQoL and reduce the number of analyses required by using a two-step approach...
December 18, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29244989/global-use-of-traditional-and-complementary-medicine-in-childhood-cancer-a-systematic-review
#10
Caroline Diorio, Catherine G Lam, Elena J Ladas, Festus Njuguna, Glenn M Afungchwi, Katherine Taromina, Stacey Marjerrison
Purpose Traditional and complementary medicine (T&CM) strategies are commonly used in pediatric oncology. Patterns may vary based on country income. We systematically reviewed published studies describing T&CM use among pediatric oncology patients in low-income countries (LIC/LMIC), middle-income countries (UMIC), and high-income countries (HIC). Objectives included describing estimated prevalence of use, reasons for use, perceived effectiveness, modalities used, rates of disclosure, and reporting of delayed or abandoned treatment...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244633/leveraging-the-global-health-service-partnership-model-for-workforce-development-in-global-radiation-oncology
#11
Omoruyi Credit Irabor, Vanessa Bradford Kerry, Juliet Matton, Wilfred Ngwa
A major contributor to the disparity in cancer outcome across the globe is the limited health care access in low- and middle-income countries that results from the shortfall in human resources for health (HRH), fomented by the limited training and leadership capacity of low-resource countries. In 2012, Seed Global Health teamed up with the Peace Corps to create the Global Health Service Partnership, an initiative that has introduced a novel model for tackling the HRH crises in developing regions of the world...
December 15, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244632/delivery-of-global-cancer-care-an-international-study-of-medical-oncology-workload
#12
Adam Fundytus, Richard Sullivan, Verna Vanderpuye, Bostjan Seruga, Gilberto Lopes, Nazik Hammad, Manju Sengar, Wilma M Hopman, Michael D Brundage, Christopher M Booth
Background To our knowledge, there is no literature that has described medical oncology (MO) workload in the global context. Here, we report results of an international study of global MO workload. Methods An online survey was distributed through a snowball method via national oncology societies to chemotherapy-prescribing physicians in 65 countries. Countries were classified into low- or low-middle-income countries (LMICs), upper-middle-income countries (UMICs), and high-income countries (HICs) on the basis of World Bank criteria...
December 15, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29242019/global-variations-in-the-level-of-cancer-related-research-activity-and-correlation-to-cancer-specific-mortality-proposal-for-a-global-curriculum
#13
C Are, A Caniglia, Mohammed Malik, L Smith, Charmaine Cummings, Carine Lecoq, R Berman, R Audisio, L Wyld
INTRODUCTION: The aim of this study was to analyze global variations in the level of cancer-related research activity and correlate this with cancer-specific mortality. METHODS: The SCOPUS database was explored to obtain data relating to the number of cancer-related publications per country. Cancer-specific mortality rates were obtained from the World Health Organization. Global variations in the level of scholarly activity were analyzed and correlated with variations in cancer-specific mortality...
December 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29242017/global-curriculum-in-research-literacy-for-the-surgical-oncologist
#14
C Are, U Yanala, G Malhotra, B Hall, L Smith, C Cummings, C Lecoq, L Wyld, R A Audisio, R S Berman
BACKGROUND: The ability to provide optimal care to cancer patients depends on awareness of current evidence-based practices emanating from research or involvement in research where circumstances permit. The significant global variations in cancer-related research activity and its correlation to cancer-specific outcomes may have an influence on the care provided to cancer patients and their outcomes. The aim of this project is to develop a global curriculum in research literacy for the surgical oncologist...
December 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29234483/the-influence-of-emerging-markets-on-the-pharmaceutical-industry
#15
REVIEW
Maya Tannoury, Zouhair Attieh
Emerging markets represent an exceptional opportunity for the pharmaceutical industry. Although a precise definition is not yet available, economists define emerging markets as developing prosperous countries in which investment is expected to result in higher income despite high risks. Qualifying a market as emerging is not merely based on the economic status of the country, but also on several criteria that render the definition applicable to each country. Jim O'Neil, retired chairman of asset management at Goldman Sachs, identified leading economies of emerging markets: Brazil, Russia, India, and China (BRIC) and later Brazil, Russia, India, China, and South Africa (BRICS) and then Mexico, Indonesia, South Korea, and Turkey (MIST), which followed years later as the second tier of nations...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29233799/a-survey-of-medical-oncology-training-in-australian-medical-schools-pilot-study
#16
Mathew George, Hiren Mandaliya, Amy Prawira
BACKGROUND: Oncology is a rapidly evolving field with continuous advancements in the diagnosis and treatment of cancer. Therefore, it is important that medical students are provided with the knowledge and experience required to care for oncology patients and enable them to diagnose and manage toxicities of novel therapeutic agents. OBJECTIVE: This study was performed to understand the medical students' perspective of the oncology education provided in universities across Australia and identify areas of education that could potentially be modified or improved to ultimately attract more students to a career in oncology...
December 12, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/29230576/global-variations-in-the-level-of-cancer-related-research-activity-and-correlation-to-cancer-specific-mortality-proposal-for-a-global-curriculum
#17
C Are, A Caniglia, Malik Mohammed, L Smith, Charmaine Cummings, Carine Lecoq, R Berman, R Audisio, L Wyld
INTRODUCTION: The aim of this study was to analyze global variations in the level of cancer-related research activity and correlate this with cancer-specific mortality. METHODS: The SCOPUS database was explored to obtain data relating to the number of cancer-related publications per country. Cancer-specific mortality rates were obtained from the World Health Organization. Global variations in the level of scholarly activity were analyzed and correlated with variations in cancer-specific mortality...
December 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29230575/global-curriculum-in-research-literacy-for-the-surgical-oncologist
#18
C Are, U Yanala, G Malhotra, B Hall, L Smith, L Wyld, C Cummings, C Lecoq, R A Audisio, R S Berman
BACKGROUND: The ability to provide optimal care to cancer patients depends on awareness of current evidence-based practices emanating from research or involvement in research where circumstances permit. The significant global variations in cancer-related research activity and its correlation to cancer-specific outcomes may have an influence on the care provided to cancer patients and their outcomes. The aim of this project is to develop a global curriculum in research literacy for the surgical oncologist...
December 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29215819/prevalence-of-malnutrition-in-hospitalized-patients-a-multicenter-cross-sectional-study
#19
Min Chang Kang, Ji Hoon Kim, Seung Wan Ryu, Jae Young Moon, Je Hoon Park, Jong Kyung Park, Jong Hoon Park, Hyun Wook Baik, Jeong Meen Seo, Myoung Won Son, Geun Am Song, Dong Woo Shin, Yeon Myung Shin, Hong Yup Ahn, Han Kwang Yang, Hee Chul Yu, Ik Jin Yun, Jae Gil Lee, Jae Myeong Lee, Jung Hwa Lee, Tae Hee Lee, Haejun Yim, Hyun Jeong Jeon, Kyuwhan Jung, Mi Ran Jung, Chi Young Jeong, Hee Sook Lim, Suk Kyung Hong
BACKGROUND: Malnutrition is associated with many adverse clinical outcomes. The present study aimed to identify the prevalence of malnutrition in hospitalized patients in Korea, evaluate the association between malnutrition and clinical outcomes, and ascertain the risk factors of malnutrition. METHODS: A multicenter cross-sectional study was performed with 300 patients recruited from among the patients admitted in 25 hospitals on January 6, 2014. Nutritional status was assessed by using the Subjective Global Assessment (SGA)...
January 8, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29208398/future-cancer-research-priorities-in-the-usa-a-lancet-oncology-commission
#20
REVIEW
Elizabeth M Jaffee, Chi Van Dang, David B Agus, Brian M Alexander, Kenneth C Anderson, Alan Ashworth, Anna D Barker, Roshan Bastani, Sangeeta Bhatia, Jeffrey A Bluestone, Otis Brawley, Atul J Butte, Daniel G Coit, Nancy E Davidson, Mark Davis, Ronald A DePinho, Robert B Diasio, Giulio Draetta, A Lindsay Frazier, Andrew Futreal, Sam S Gambhir, Patricia A Ganz, Levi Garraway, Stanton Gerson, Sumit Gupta, James Heath, Ruth I Hoffman, Cliff Hudis, Chanita Hughes-Halbert, Ramy Ibrahim, Hossein Jadvar, Brian Kavanagh, Rick Kittles, Quynh-Thu Le, Scott M Lippman, David Mankoff, Elaine R Mardis, Deborah K Mayer, Kelly McMasters, Neal J Meropol, Beverly Mitchell, Peter Naredi, Dean Ornish, Timothy M Pawlik, Jeffrey Peppercorn, Martin G Pomper, Derek Raghavan, Christine Ritchie, Sally W Schwarz, Richard Sullivan, Richard Wahl, Jedd D Wolchok, Sandra L Wong, Alfred Yung
We are in the midst of a technological revolution that is providing new insights into human biology and cancer. In this era of big data, we are amassing large amounts of information that is transforming how we approach cancer treatment and prevention. Enactment of the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in the advancement of knowledge, providing nearly US$2 billion of funding for cancer research and precision medicine. In 2016, the Blue Ribbon Panel (BRP) set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment...
November 2017: Lancet Oncology
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