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Global oncology

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https://www.readbyqxmd.com/read/28529992/minimally-invasive-surgery-for-gastric-cancer-in-usa-current-status-and-future-perspectives
#1
REVIEW
Ashley Russo, Vivian E Strong
The World Health Organization (WHO) has declared gastric carcinoma a global health concern and gastric cancer remains the third leading cause of cancer deaths worldwide. With the rising incidence of gastric cancer, a body of both retrospective and randomized data has emerged since the early 1990's evaluating the role of minimally invasive platforms in the management of gastric cancer. While Eastern studies have shown that the laparoscopic approach is safe and feasible for advanced gastric cancer in Eastern patients, it is not clear whether this is true for patients in the West...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28512049/space-occupying-tumor-bed-cysts-as-a-complication-of-modern-treatment-for-high-grade-glioma
#2
Thomas Beez, Sven Burgula, Marcel Kamp, Marion Rapp, Hans-Jakob Steiger, Michael Sabel
INTRODUCTION: Management of high grade glioma (HGG) was changed by recent landmark trials and is nowadays more proactive. However, aggressive treatment leads to hospitalization due to side effects. Space-occupying tumor bed cysts have been described, but not systematically assessed. We sought to analyze this complication in a contemporary HGG cohort. METHODS: A retrospective review of HGG patients treated between 2007 and 2013 was performed, patients with space-occupying tumor bed cysts were identified and their hospital notes reviewed for relevant variables...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28506827/how-tumor-growth-can-be-influenced-by-delayed-interactions-between-cancer-cells-and-the-microenvironment
#3
Dibakar Ghosh, Subhas Khajanchi, Sylvain Mangiarotti, Fabrice Denis, Syamal K Dana, Christophe Letellier
If recent advances in oncology emphasized the role of microenvironment in tumor growth, the role of delays for modeling tumor growth is still uncertain. In this paper, we considered a model, describing the interactions of tumor cells with their microenvironment made of immune cells and host cells, in which we inserted, as suggested by the clinicians, two time delays, one in the interactions between tumor cells and immune cells and, one in the action of immune cells on tumor cells. We showed analytically that the singular point associated with the co-existence of the three cell populations loses its stability via a Hopf bifurcation...
May 12, 2017: Bio Systems
https://www.readbyqxmd.com/read/28497184/management-of-hydrocephalus-in-pediatric-metastatic-tumors-of-the-posterior-fossa-at-presentation
#4
Luc Le Fournier, Matthieu Delion, Maxime Esvan, Emilie De Carli, Céline Chappé, Philippe Mercier, Philippe Menei, Laurent Riffaud
PURPOSE: Presence of metastases in newly diagnosed pediatric posterior fossa tumors (PFT) is not a rare situation, but optimal treatment of associated hydrocephalus in these children has remained undetermined. METHODS: Twenty-nine children treated between January 2005 and December 2015 for a metastatic PFT associated with hydrocephalus constituted the study cohort. Patients were divided into three groups: ventriculoperitoneal shunt (VPS), endoscopic third ventriculostomy (ETV), and temporary ventricular drainage before or during tumor resection (PVD)...
May 11, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28489488/radiation-induced-fibrosis-mechanisms-and-opportunities-to-mitigate-report-of-an-nci-workshop-september-19-2016
#5
Deborah E Citrin, Pataje G S Prasanna, Amanda J Walker, Michael L Freeman, Iris Ekea, Mary Helen Barcellos-Hoff, Molykutty J Arankalayil, Eric P Cohen, Ruth C Wilkins, Mansoor M Ahmed, Mitchell S Anscher, Benjamin Movsas, Jeffrey C Buchsbaum, Marc S Mendonca, Thomas A Wynn, C Norman Coleman
A workshop entitled "Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate" (held in Rockville, MD, September 19, 2016) was organized by the Radiation Research Program and Radiation Oncology Branch of the Center for Cancer Research (CCR) of the National Cancer Institute (NCI), to identify critical research areas and directions that will advance the understanding of radiation-induced fibrosis (RIF) and accelerate the development of strategies to mitigate or treat it. Experts in radiation biology, radiation oncology and related fields met to identify and prioritize the key areas for future research and clinical translation...
May 10, 2017: Radiation Research
https://www.readbyqxmd.com/read/28488104/health-related-quality-of-life-in-patients-with-hepatocellular-carcinoma-treated-with-initial-transarterial-chemoembolization
#6
Jan B Hinrichs, Davut B Hasdemir, Maximilian Nordlohne, Nora Schweitzer, Frank Wacker, Arndt Vogel, Martha M Kirstein, Steffen Marquardt, Thomas Rodt
PURPOSE: To investigate the impact of the first transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) on health-related quality of life (HRQoL) and identify predictors for low HRQoL following TACE. MATERIALS AND METHODS: HRQoL was prospectively evaluated in 79 patients with standardized questionnaires (QlQ-C30 and HCC18) pre- and 2 weeks post-TACE. Treatment response was evaluated using common tumour response criteria. Clinical parameters [e...
May 9, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28482700/clinical-development-of-ct-p10-and-other-biosimilar-cancer-therapeutics
#7
Won Seog Kim, Bertrand Coiffier, Hyuk-Chan Kwon, SuYeon Kim
Biosimilars are highly similar versions of approved biologic drugs that may confer equivalent efficacy at a reduced cost. Patents for several biological cancer therapeutics are past or approaching expiry, presenting an opportunity to increase affordability and global accessibility of key drugs through the development of biosimilars. To receive approval, a biosimilar must show no clinically meaningful differences from the reference product in terms of efficacy or safety. The first monoclonal antibody biosimilar cancer therapeutic to gain approval was CT-P10, a biosimilar of rituximab...
May 2017: Future Oncology
https://www.readbyqxmd.com/read/28477160/current-status-of-biosimilars-in-oncology
#8
REVIEW
Luis H Camacho
Four medicinal cancer biological blockbusters will end their patent lifespan by 2020. It is estimated that the total market for cancer biologicals will reach approximately US$68 billion at that time. Approximately 20 biosimilars have entered the European market since the launch of the original approval guidelines in 2005, and four biosimilars have been approved in the USA since 2015. Data from European countries with the highest market entrance of biosimilars suggest that the incorporation of biosimilars into healthcare systems worldwide may result in a 30-45% cost savings...
June 2017: Drugs
https://www.readbyqxmd.com/read/28475230/outcomes-of-a-pediatric-surgical-oncology-fellowship-in-a-pediatric-cancer-institution
#9
I Fernandez-Pineda, D Sanders, B N Rao, S J Shochat, A M Davidoff
Surgery plays an important role as part of the treatment plan in most children with malignant solid tumors in regards to initial biopsy, upfront resection, and delayed resection. Surgeons also play a critical role in the treatment of surgical complications that may arise during medical treatment. The pediatric surgical oncologist should be familiar with the current treatment guidelines, histology implications, chemotherapy and radiation side effects, tumor staging, and overall care of the child with cancer...
May 5, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28468016/treating-hepatobiliary-cancers-the-oncology-way
#10
Peter Robert Galle
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. HCC represents more than 90% of primary liver cancers. There is growing incidence of HCC worldwide. In the western world, HCC arises in a cirrhotic background in up to 90% of cases, and cirrhosis itself is a progressive disease that affects patient survival. Thus, outcome in patients with HCC and the chances for anti-tumor treatment and it is results are dependent not only on tumor-associated factors but also on the liver function...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28462642/oncological-and-quality-of-life-outcomes-following-extralevator-versus-standard-abdominoperineal-excision-for-rectal-cancer
#11
D Kamali, A Sharpe, A Musbahi, A Reddy
INTRODUCTION There is increasing and conflicting research debating the oncological benefits of extralevator abdominoperineal excision (ELAPE) compared with standard abdominoperineal excision (SAPE). However, there is very little in the literature on the long-term effects on patients' wellbeing following the two procedures. The aim of this study was to determine the oncological outcomes and long-term quality of life (QoL) of patients at two hospitals having undergone ELAPE or SAPE. METHODS Consecutive patients with rectal cancer who underwent either ELAPE or SAPE between January 2009 and June 2015 at a single centre were analysed...
May 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28455152/defining-a-leader-role-curriculum-for-radiation-oncology-a-global-delphi-consensus-study
#12
Sandra Turner, Matthew Seel, Theresa Trotter, Meredith Giuliani, Kim Benstead, Jesper G Eriksen, Philip Poortmans, Christine Verfaillie, Henrike Westerveld, Shamira Cross, Ming-Ka Chan, Timothy Shaw
BACKGROUND AND PURPOSE: The need for radiation oncologists and other radiation oncology (RO) professionals to lead quality improvement activities and contribute to shaping the future of our specialty is self-evident. Leadership knowledge, skills and behaviours, like other competencies, can be learned (Blumenthal et al., 2012). The objective of this study was to define a globally applicable competency set specific to radiation oncology for the CanMEDS Leader Role (Frank et al., 2015). METHODS: A modified Delphi consensus process delivering two rounds of on-line surveys was used...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28453751/the-neurologic-assessment-in-neuro-oncology-nano-scale-a-tool-to-assess-neurologic-function-for-integration-into-the-response-assessment-in-neuro-oncology-rano-criteria
#13
Lakshmi Nayak, Lisa M DeAngelis, Alba A Brandes, David M Peereboom, Evanthia Galanis, Nancy U Lin, Riccardo Soffietti, David R Macdonald, Marc Chamberlain, James Perry, Kurt Jaeckle, Minesh Mehta, Roger Stupp, Alona Muzikansky, Elena Pentsova, Timothy Cloughesy, Fabio M Iwamoto, Joerg-Christian Tonn, Michael A Vogelbaum, Patrick Y Wen, Martin J van den Bent, David A Reardon
Background.: The Macdonald criteria and the Response Assessment in Neuro-Oncology (RANO) criteria define radiologic parameters to classify therapeutic outcome among patients with malignant glioma and specify that clinical status must be incorporated and prioritized for overall assessment. But neither provides specific parameters to do so. We hypothesized that a standardized metric to measure neurologic function will permit more effective overall response assessment in neuro-oncology. Methods...
May 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28453528/guidance-in-author-instructions-of-hematology-and-oncology-journals-a-cross-sectional-and-longitudinal-study
#14
Ingrid Toews, Nadine Binder, Robert F Wolff, Guenes Toprak, Erik von Elm, Joerg J Meerpohl
BACKGROUND: The debate about the value of biomedical publications led to recommendations for improving reporting quality. It is unclear to what extent these recommendations have been endorsed by journals. We analyzed whether specific recommendations were included in author instructions, which journal characteristics were associated with their endorsement, how endorsement of the domains changed and whether endorsement was associated with change of impact factor between 2010 and 2015. METHODS: We considered two study samples consisting of "Hematology" and "Oncology" journals of the Journal Citation Report 2008 and 2014, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28452903/zonisamide-in-brain-tumor-related-epilepsy-an-observational-pilot-study
#15
Marta Maschio, Loredana Dinapoli, Alessia Zarabla, Andrea Maialetti, Diana Giannarelli, Alessandra Fabi, Antonello Vidiri, Tonino Cantelmi
OBJECTIVES: Epilepsy heavily affects the quality of life (QoL) of patients with brain tumor because in addition to taking treatments for the oncological illness, patients are required to live with the long-term taking of antiepileptic drugs (AEDs). The AEDs' adverse effects are common in these patients and can negatively influence their perceptions of their QoL.We conducted an observational pilot study in patients with brain tumor-related epilepsy to verify efficacy, tolerability, and impact on QoL and global neurocognitive performances of zonisamide (ZNS) in add-on...
May 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28451418/southwestern-oncology-group-pretreatment-risk-criteria-as-predictive-or-prognostic-factors-in-acute-myeloid-leukemia
#16
Ana Espirito Santo, Sergio Chacim, Isabel Ferreira, Luis Leite, Claudia Moreira, Dulcineia Pereira, Margarida Dantas, Marta Nunes, Luisa Viterbo, Ilidia Moreira, Angelo Martins, Isabel Oliveira, Nelson Domingues, Jose Mariz, Rui Medeiros
Acute myeloid leukemia (AML) is a clonal hematological malignant condition and the implications of pretreatment risk criteria as predictive or prognostic factors are constantly under evaluation. With this study, the authors' intent was to characterize AML patients and to evaluate the clinical outcome associated with Southwestern Oncology Group (SWOG) coding pretreatment risk criteria/cytogenetic score. Between 2002 and 2010, 225 patients were diagnosed with AML at the Portuguese Institute of Oncology (Porto, Portugal)...
March 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28447001/overview-of-esophageal-cancer
#17
Ghulam Abbas, Mark Krasna
Esophageal cancer is a male-dominant aggressive malignancy and a leading cause of cancer-related mortality worldwide. Squamous cell carcinoma and adenocarcinoma are the two predominant histological subtypes with varying geographical and racial distribution. Globally, squamous cell carcinoma remains the most common histological type. In Western countries, however, adenocarcinoma has become the leading histological subtype, corresponding to a rise in the incidence of obesity, gastro-esophageal reflux disease and Barrett's esophagus...
March 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28437395/global-survey-of-the-immunomodulatory-potential-of-common-drugs
#18
Gregory I Vladimer, Berend Snijder, Nikolaus Krall, Johannes W Bigenzahn, Kilian V M Huber, Charles-Hugues Lardeau, Kumar Sanjiv, Anna Ringler, Ulrika Warpman Berglund, Monika Sabler, Oscar Lopez de la Fuente, Paul Knöbl, Stefan Kubicek, Thomas Helleday, Ulrich Jäger, Giulio Superti-Furga
Small-molecule drugs may complement antibody-based therapies in an immune-oncology setting, yet systematic methods for the identification and characterization of the immunomodulatory properties of these entities are lacking. We surveyed the immumomodulatory potential of 1,402 small chemical molecules, as defined by their ability to alter the cell-cell interactions among peripheral mononuclear leukocytes ex vivo, using automated microscopy and population-wide single-cell image analysis. Unexpectedly, ∼10% of the agents tested affected these cell-cell interactions differentially...
June 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28426537/supportive-care-needs-and-association-with-quality-of-life-of-mexican-adults-with-solid-cancers
#19
Svetlana V Doubova, Maria Guadalupe Casales-Hernández, Ricardo Perez-Cuevas
BACKGROUND: Patients with cancer have supportive care needs. Studies that analyze the relationship between supportive care needs and health-related quality of life (HRQoL) are scarce. Cultural differences in supportive care needs and perceived QoL are also worth analyzing. OBJECTIVE: The aim of this study was to assess the association between supportive care needs and HRQoL of Mexican adults given a diagnosis of solid cancers. METHODS: We performed a secondary data analysis of a cross-sectional survey of 825 adult patients with cancer treated at the Oncology Hospital of the Mexican Institute of Social Security...
April 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28425888/-satisfa%C3%A3-%C3%A3-o-com-o-internato-m%C3%A3-dico-em-portugal
#20
Miguel Bigotte Vieira, Pedro Godinho, Nuno Gaibino, Raquel Dias, Agostinho Sousa, Inês Madanelo, Francisco Ribeiro-Mourão, Mariana Brandão, Sónia Duarte, Tiago Meirinhos, Ana Luísa Catarino, Cláudio Espírito Santo, Ricardo Caiado, Ricardo Marques, Ana Gonçalves Ferreira, Carlos Ramalheira, João Valente Jorge, Marta Losada, Mário Santos, Edson Oliveira, João Paulo Farias, José Manuel Silva
INTRODUCTION: In the last years, the global context of medical education and Medical Residency programs in Portugal suffered substantial changes. The primary objective of this study was to evaluate and characterize medical residents ́ satisfaction with medical residency programs in Portugal and to identify features that could be improved. MATERIAL AND METHODS: We utilized as model the survey Postgraduate Hospital Educational Environment Measure that has been developed in the United Kingdom and is speci cally targeted to medical residents...
December 30, 2016: Acta Médica Portuguesa
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