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https://www.readbyqxmd.com/read/27880869/the-impact-of-metagenomic-interplay-on-the-mosquito-redox-homeostasis
#1
REVIEW
Cody J Champion, Jiannong Xu
Mosquitoes are exposed to oxidative challenges throughout their life cycle. The primary challenge comes from a blood meal. The blood digestion turns the midgut into an oxidative environment, which imposes pressure not only on mosquito fecundity and other physiological traits but also on the microbiota in the midgut. During evolution, mosquitoes have developed numerous oxidative defense mechanisms to maintain redox homeostasis in the midgut. In addition to antioxidants, SOD, catalase, and glutathione system, sufficient supply of the reducing agent, NADPH, is vital for a successful defense against oxidative stress...
November 20, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27864235/l5-ldl-from-st-elevation-myocardial-infarction-patients-induces-il-1%C3%AE-production-via-lox-1-and-nlrp3-inflammasome-activation-in-macrophages
#2
Tzu-Ching Yang, Po-Yuan Chang, Shao-Chun Lu
L5-LDL, the most electronegative LDL associated with major cardiovascular risks, significantly rises in patients with ST-segment elevation myocardial infarction (STEMI). The inflammatory nature of atherosclerotic vascular diseases has prompted us to investigate whether L5-LDL induces the production of inflammatory cytokines, especially vascular ischemia-related interleukin (IL)-1β in the pathogenesis of STEMI. Clinical data showed that plasma levels of L5-LDL and IL-1β were higher in the STEMI patients than in the controls (p < 0...
November 18, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27857715/complementary-roles-of-the-classical-and-lectin-complement-pathways-in-the-defense-against-aspergillus-fumigatus
#3
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Mikkel-Ole Skjoedt, Gregory L Stahl, Peter Garred
Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear. The aim of this study was to unravel the role of the classical, lectin, and alternative pathways under both immunocompetent and immunocompromised conditions to provide a relevant dual-perspective on the response against A. fumigatus. Conidia (spores) from a clinical isolate of A...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27793997/age-specific-adjuvant-synergy-dual-tlr7-8-and-mincle-activation-of-human-newborn-dendritic-cells-enables-th1-polarization
#4
Simon D van Haren, David J Dowling, Willemina Foppen, Dennis Christensen, Peter Andersen, Steven G Reed, Robert M Hershberg, Lindsey R Baden, Ofer Levy
Due to functionally distinct cell-mediated immunity, newborns and infants are highly susceptible to infection with intracellular pathogens. Indeed, neonatal Ag-presenting dendritic cells (DCs) demonstrate impaired Th1 responses to many candidate adjuvants, including most TLR agonists (TLRAs). Combination adjuvantation systems may provide enhanced immune activation but have typically been developed without regard to the age of the target population. We posited that distinct combinations of TLRAs and C-type lectin receptor agonists may enhance Th1 responses of newborn DCs...
October 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27782319/dangerous-liaisons-complement-coagulation-and-kallikrein-kinin-cross-talk-act-as-a-linchpin-in-the-events-leading-to-thromboinflammation
#5
REVIEW
Kristina N Ekdahl, Yuji Teramura, Osama A Hamad, Sana Asif, Claudia Duehrkop, Karin Fromell, Elisabet Gustafson, Jaan Hong, Huda Kozarcanin, Peetra U Magnusson, Markus Huber-Lang, Peter Garred, Bo Nilsson
Innate immunity is fundamental to our defense against microorganisms. Physiologically, the intravascular innate immune system acts as a purging system that identifies and removes foreign substances leading to thromboinflammatory responses, tissue remodeling, and repair. It is also a key contributor to the adverse effects observed in many diseases and therapies involving biomaterials and therapeutic cells/organs. The intravascular innate immune system consists of the cascade systems of the blood (the complement, contact, coagulation, and fibrinolytic systems), the blood cells (polymorphonuclear cells, monocytes, platelets), and the endothelial cell lining of the vessels...
November 2016: Immunological Reviews
https://www.readbyqxmd.com/read/27774692/isolation-and-partial-characterization-of-3-nontoxic-d-galactose-specific-isolectins-from-seeds-of-momordica-balsamina
#6
Amna K E Awadallah, Makarim Elfadil M Osman, Mariam A Ibrahim, Emerson S Bernardes, Marcelo Dias-Baruffi, Emadeldin Hassan E Konozy
Three isolectins denoted hereforth MBaL-30, MBaL-60, and MBaL-80 were isolated from seeds extract of Momordica balsamina by 30%, 60%, and 80% ammonium sulfate saturations, respectively. The native molecular weights of these lectins, as judged by gel filtration, were 108, 56, and 160 kDa, respectively. On SDS-PAGE, under reduced condition, 27 kDa band was obtained for all isolectins. The lectins hemagglutinating activities were variably inhibited by d-galactose (minimum inhibitory concentrations = 12.5mM, 50mM, and 0...
October 24, 2016: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27766148/expression-profile-of-novel-cell-surface-molecules-on-different-subsets-of-human-peripheral-blood-antigen-presenting-cells
#7
Daniela Damasceno, Martín Pérez Andrés, Wouter Bl van den Bossche, Juan Flores-Montero, Sandra de Bruin, Cristina Teodosio, Jacques Jm van Dongen, Alberto Orfao, Julia Almeida
Although major steps have been recently made in understanding the role of the distinct subsets of dendritic cells (DC)/antigen-presenting cells (APC), further studies are required to unravel their precise role, including in-depth immunophenotypic characterisation of these cells. Here, we used eight-colour flow cytometry to investigate the reactivity of a panel of 72 monoclonal antibodies (including those clustered in seven new Cluster of Differentiation, CD) on different subsets of APC in peripheral blood (PB) samples from five healthy adults...
September 2016: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/27729229/bacterial-membrane-binding-and-pore-formation-abilities-of-carbohydrate-recognition-domain-of-fish-lectin
#8
Abirami Arasu, Venkatesh Kumaresan, Rajesh Palanisamy, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Munuswamy-Ramanujam Ganesh, Jesu Arockiaraj
Antimicrobial peptides (AMPs) are innate molecules that are found in a wide variety of species ranging from bacteria to humans. In recent years, excessive usage of antibiotics resulted in development of multi-drug resistant pathogens which made researchers to focus on AMPs as potential substitute for antibiotics. Lily type mannose-binding lectin is an extended super-family of structurally and evolutionarily related sugar binding proteins. These lectins are well-known AMPs which play important roles in fish defense mechanism...
October 8, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27720695/cd94-of-tongue-sole-cynoglossus-semilaevis-binds-a-wide-arrange-of-bacteria-and-possesses-antibacterial-activity
#9
Xue-Peng Li, Yong-Hua Hu
In this study, we examined the expression patterns and the functions of the tongue sole Cynoglossus semilaevis CD94, CsCD94. CsCD94 is composed of 209 amino acid residues and shares 43.0-50.2% overall identities with known teleost CD94 sequence. CsCD94 has a C-type lectin-like domain. Expression of CsCD94 occurred in multiple tissues and was upregulated during bacterial infection. Recombinant CsCD94 (rCsCD94) exhibited apparent binding and agglutinating activities against both Gram-positive and Gram-negative bacteria in a Ca(2+)-dependent manner...
October 5, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27677574/the-hookworm-ancylostoma-ceylanicum-intestinal-transcriptome-provides-a-platform-for-selecting-drug-and-vaccine-candidates
#10
Junfei Wei, Ashish Damania, Xin Gao, Zhuyun Liu, Rojelio Mejia, Makedonka Mitreva, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan
BACKGROUND: The intestine of hookworms contains enzymes and proteins involved in the blood-feeding process of the parasite and is therefore a promising source of possible vaccine antigens. One such antigen, the hemoglobin-digesting intestinal aspartic protease known as Na-APR-1 from the human hookworm Necator americanus, is currently a lead candidate antigen in clinical trials, as is Na-GST-1 a heme-detoxifying glutathione S-transferase. METHODS: In order to discover additional hookworm vaccine antigens, messenger RNA was obtained from the intestine of male hookworms, Ancylostoma ceylanicum, maintained in hamsters...
September 27, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27660287/nicotine-mediates-cd161a-renal-macrophage-infiltration-and-premature-hypertension-in-the-spontaneously-hypertensive-rat
#11
Sailesh C Harwani, Jason Ratcliff, Fayyaz S Sutterwala, Zuhair K Ballas, David K Meyerholz, Mark W Chapleau, Francois Abboud
RATIONALE: Renal inflammation contributes to the pathophysiology of hypertension. CD161a+ immune cells are dominant in the Spontaneously Hypertensive Rat (SHR) and expand in response to nicotinic cholinergic activation. OBJECTIVE: We aimed to phenotype CD161a+ immune cells in pre-hypertensive SHR following cholinergic activation with nicotine, and determine if these cells are involved in renal inflammation and the development of hypertension. METHODS AND RESULTS: Studies utilized young SHR and Wistar Kyoto (WKY) rats...
September 22, 2016: Circulation Research
https://www.readbyqxmd.com/read/27645999/the-lectin-like-domain-of-tnf-increases-enac-open-probability-through-a-novel-site-at-the-interface-between-the-second-transmembrane-and-c-terminal-domains-of-the-%C3%AE-subunit
#12
Rudolf Lucas, Qiang Yue, Abdel Alli, Billie Jeanne Duke, Otor Al-Khalili, Tiffany L Thai, Jürg Hamacher, Supriya Sridhar, Iryna Lebedyeva, Huabo Su, Susan Tzotzos, Bernhard Fischer, Armanda Formigao Gameiro, Maria Loose, Trinad Chakraborty, Waheed Shabbir, Mohammed Aufy, Rosa Lemmens-Gruber, Douglas C Eaton, Istvan Czikora
Regulation of the epithelial sodium channel (ENaC), which regulates fluid homeostasis and blood pressure, is complex and remains incompletely understood. The TIP peptide, a mimic of the lectin-like domain of TNF, activates ENaC by binding to glycosylated residues in the extracellular loop of ENaC-α, as well as to a hitherto uncharacterized internal site. Molecular docking studies suggested three residues, Val(567), Glu(568), and Glu(571), located at the interface between the second transmembrane and C-terminal domains of ENaC-α, as a critical site for binding of the TIP peptide...
November 4, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27602567/towards-a-proteomic-catalogue-and-differential-annotation-of-salivary-gland-proteins-in-blood-fed-malaria-vector-anopheles-culicifacies-by-mass-spectrometry
#13
Ritu Rawal, Sonam Vijay, Kavita Kadian, Jagbir Singh, Veena Pande, Arun Sharma
In order to understand the importance of functional proteins in mosquito behavior, following blood meal, a baseline proteomic dataset is essential for providing insights into the physiology of blood feeding. Therefore, in this study as first step, in solution and 1-D electrophoresis digestion approach combined with tandem mass spectrometry (nano LC-MS/MS) and computational bioinformatics for data mining was used to prepare a baseline proteomic catalogue of salivary gland proteins of sugar fed An. culicifacies mosquitoes...
2016: PloS One
https://www.readbyqxmd.com/read/27600584/differential-expression-of-o-glycans-in-cd4-t-lymphocytes-from-patients-with-systemic-lupus-erythematosus
#14
Edgar Ramos-Martínez, Ricardo Lascurain, Eda Patricia Tenorio, Antonio Sánchez-González, Karina Chávez-Rueda, Luis Chávez-Sánchez, Luis J Jara-Quezada, Raúl Chávez-Sánchez, Edgar Zenteno, Francisco Blanco-Favela
T cells from patients with systemic lupus erythematosus (SLE) show a decreased activation threshold and increased apoptosis. These processes seem to be regulated by glycosylated molecules on the T cell surface. Here, we determined through flow cytometry the expression of mucin-type O-glycans on T helper cells in peripheral blood mononuclear cells (PBMC) from 23 SLE patients and its relation with disease activity. We used lectins specific for the disaccharide Gal-GalNAc, such as Amaranthus leucocarpus lectin (ALL), Artocarpus integrifolia lectin (jacalin) and Arachis hypogaea lectin (peanut agglutinin, PNA), as well as lectins for sialic acid such as Sambucus nigra agglutinin (SNA) and Maakia amurensis agglutinin (MAA)...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27567920/expression-of-a-novel-endothelial-marker-c-type-lectin-14a-in-epithelial-ovarian-cancer-and-its-prognostic-significance
#15
S Krishna Priya, Kishore Kumar, K R Hiran, M R Bindhu, Rohit P Nagare, D K Vijaykumar, T S Ganesan
OBJECTIVE: The purpose of this study was to evaluate microvessel density (MVD) as assessed by C-type lectin 14A (CLEC14A), which is a new marker for endothelial cells, and compare its expression to CD31 and CD105 in epithelial ovarian cancer (EOC). METHODS: MVD was evaluated in tumors (n = 50) from patients with EOC who underwent primary surgery and in patients with EOC who received preoperative chemotherapy (n = 49) using immunohistochemistry with antibodies to CLEC14A, CD31 and CD105...
August 27, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27565408/the-role-of-a-novel-c-type-lectin-like-protein-from-planarian-in-innate-immunity-and-regeneration
#16
Lili Gao, Yu Han, Hongkuan Deng, Wenjing Hu, Hui Zhen, Na Li, Nianci Qin, Meihui Yan, Weiwei Wu, Baohua Liu, Bosheng Zhao, Qiuxiang Pang
Planarian, a representative of platyhelminthes, has strong regeneration ability and less complicated innate immune system. However, planarian immune system remains poorly understood. In this paper, a novel C-type lectin-like protein, namely, DjCTL was identified and characterized in Dugesia japonica. DjCTL was mainly expressed in the pharyngeal and epidermis and up-regulated upon the induction of lipopolysaccharide (LPS), peptidoglycan (PGN), Gram-positive and Gram-negative bacteria indicating that DjCTL may be involved in the immune responses...
August 23, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27550195/introduction-of-h-antigens-into-oligosaccharides-and-sugar-chains-of-glycoproteins-using-highly-efficient-1-2-%C3%AE-l-fucosynthase
#17
Yuta Sugiyama, Aina Gotoh, Toshihiko Katoh, Yuji Honda, Erina Yoshida, Shin Kurihara, Hisashi Ashida, Hidehiko Kumagai, Kenji Yamamoto, Motomitsu Kitaoka, Takane Katayama
Fucα1-2 Gal linkages, or H-antigens, constitute histo-blood group antigens and are involved in various physiological processes. In addition, recent studies have shown that the H-antigen-containing glycans play an important role, not only in establishing harmonious relationship between gut microbes and the host, but also in preventing gut dysbiosis-related diseases. Therefore, development of an efficient method for introducing Fuc residue at Gal residue at the non-reducing end of glycans via α-(1→2) linkage is desired for research as well as medicinal purposes...
August 22, 2016: Glycobiology
https://www.readbyqxmd.com/read/27488655/development-and-optimization-of-a-competitive-binding-assay-for-the-galactophilic-low-affinity-lectin-leca-from-pseudomonas-aeruginosa
#18
Ines Joachim, Sebastian Rikker, Dirk Hauck, Daniela Ponader, Sophia Boden, Roman Sommer, Laura Hartmann, Alexander Titz
Infections with the Gram-negative bacterium Pseudomonas aeruginosa result in a high mortality among immunocompromised patients and those with cystic fibrosis. The pathogen can switch from planktonic life to biofilms, and thereby shields itself against antibiotic treatment and host immune defense to establish chronic infections. The bacterial protein LecA, a C-type lectin, is a virulence factor and an integral component for biofilm formation. Inhibition of LecA with its carbohydrate ligands results in reduced biofilm mass, a potential Achilles heel for treatment...
August 16, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27473744/successful-abo-incompatible-renal-transplantation-%C3%A2-blood-group-a1b-donor-into-a2b-recipient-with-anti-a1-isoagglutinins
#19
Emmanuel A Fadeyi, Robert J Stratta, Alan C Farney, Gregory J Pomper
OBJECTIVES: Transplantation of the blood group A2B in a recipient was successfully performed in the setting of receiving a deceased donor kidney from an "incompatible" A1B donor. METHODS: The donor and recipient were both typed for ABO blood group, including ABO genotyping. The donor and recipient were tested for ABO, non-ABO, and human leukocyte antigen (HLA) antibodies. The donor and recipient were typed for HLA antigens, including T- and B-flow cytometry crossmatch tests...
August 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27443248/e3-ubiquitin-ligase-chip-interacts-with-c-type-lectin-like-receptor-clec-2-and-promotes-its-ubiquitin-proteasome-degradation
#20
Miaomiao Shao, Lili Li, Shushu Song, Weicheng Wu, Peike Peng, Caiting Yang, Mingming Zhang, Fangfang Duan, Dongwei Jia, Jie Zhang, Hao Wu, Ran Zhao, Lan Wang, Yuanyuan Ruan, Jianxin Gu
C-type lectin-like receptor 2 (CLEC-2) was originally identified as a member of non-classical C-type lectin-like receptors in platelets and immune cells. Activation of CLEC-2 is involved in thrombus formation, lymphatic/blood vessel separation, platelet-mediated tumor metastasis and immune response. Nevertheless, the regulation of CLEC-2 expression is little understood. In this study, we identified that the C terminus of Hsc70-interacting protein (CHIP) interacted with CLEC-2 by mass spectrometry analysis, and CHIP decreased the protein expression of CLEC-2 through lysine-48-linked ubiquitination and proteasomal degradation...
October 2016: Cellular Signalling
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