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https://www.readbyqxmd.com/read/29674003/tanshinone-iia-suppresses-fc%C3%AE%C2%B5ri-mediated-mast-cell-signaling-and-anaphylaxis-by-activation-of-the-sirt1-lkb1-ampk-pathway
#1
Xian Li, Soon Jin Park, Fansi Jin, Yifeng Deng, Ju Hye Yang, Jae-Hoon Chang, Dong-Young Kim, Jung-Ae Kim, Youn Ju Lee, Makoto Murakami, Kun Ho Son, Hyeun Wook Chang
AMP-activated protein kinase (AMPK) and its upstream mediators liver kinase B1 (LKB1) and sirtuin 1 (Sirt1) are generally known as key regulators of metabolism. We have recently reported that the AMPK pathway negatively regulates mast cell activation and anaphylaxis. Tanshinone IIA (Tan IIA), an active component of Salvia miltiorrhiza extract that is currently used for the treatment of cardiovascular and cerebrovascular diseases, shows anti-diabetic activity and improves insulin resistance in db/db mice through activation of AMPK...
April 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29664427/effect-of-statins-on-sirtuin-1-and-endothelial-nitric-oxide-synthase-expression-in-young-patients-with-a-history-of-premature-myocardial-infarction
#2
Aylin Hatice Yamaç, Ülkan Kılıç
OBJECTIVE: The present study was an investigation of the effect of statins on the expression of circulating sirtuin 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) proteins, and on the distribution of single nucleotide polymorphisms (SNPs) of the SIRT1 gene in patients with a history of premature myocardial infarction (PMI). METHODS: A total of 108 patients who had suffered from a premature ST-elevation myocardial infarction (STEMI) under the age of 45 years were enrolled in this study...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29651144/sirtuin-7-deficiency-ameliorates-cisplatin-induced-acute-kidney-injury-through-regulation-of-the-inflammatory-response
#3
Yoshikazu Miyasato, Tatsuya Yoshizawa, Yoshifumi Sato, Terumasa Nakagawa, Yuko Miyasato, Yutaka Kakizoe, Takashige Kuwabara, Masataka Adachi, Alessandro Ianni, Thomas Braun, Yoshihiro Komohara, Masashi Mukoyama, Kazuya Yamagata
Cisplatin-induced acute kidney injury (AKI) has been recognized as one of cisplatin's serious side effects, limiting its use in cancer therapy. Sirtuin 1 (SIRT1) and SIRT3 play protective roles against cisplatin-induced kidney injury. However, the role of SIRT7 in cisplatin-induced kidney injury is not yet known. In this study, we found that Sirt7 knockout (KO) mice were resistant to cisplatin-induced AKI. Furthermore, our studies identified that loss of SIRT7 decreases the expression of tumor necrosis factor-α (TNF-α) by regulating the nuclear expression of the transcription factor nuclear factor kappa B...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29648516/the-phosphodiesterase-4-inhibitor-roflumilast-reverts-proteolysis-in-skeletal-muscle-cells-of-patients-with-copd-cachexia
#4
Esther Barreiro, Ester Puig-Vilanova, Anna Salazar-Degracia, Sergi Pascual-Guardia, Carme Casadevall, Joaquim Gea
Peripheral muscle weakness and mass loss are characteristic features in severe COPD. We hypothesized that the phosphodiesterase-4 inhibitor roflumilast-induced cAMP may ameliorate proteolysis and metabolism in skeletal muscles of COPD patients with severe muscle wasting. In myogenic precursor cells (isolated from muscle biopsies and cultured up to obtain differentiated myotubes) from 10 severe COPD patients and 10 healthy controls, which were treated with 1 microM roflumilast N-oxide (RNO) for three time-cohorts (1h, 6h, and 24h), genes of antioxidant defense and oxidative stress marker, myogenesis and muscle metabolism, proteolysis (tyrosine release assay) and ubiquitin-proteasome system markers, autophagy, and myosin isoforms were analyzed using RT-PCR and immunoblotting...
April 12, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29626110/impaired-endocrine-metabolic-homeostasis-underlying-mechanism-of-its-induction-by-unbalanced-diet
#5
Bárbara Maiztegui, Carolina Lisi Román, Juan José Gagliardino, Luis Emilio Flores
Aim : to characterize the intrinsic mechanism by which sucrose induces β-cell dysfunction. Methods : Normal rats received for 3 weeks a standard diet supplemented with 10% sucrose in the drinking water (HS) with/out an antioxidant agent (R/S α-lipoic acid). We measured plasma glucose, insulin, triglyceride, leptin and lipid peroxidation levels; homeostasis model assessment-insulin resistance (HOMA-IR) and HOMA-β indexes were also determined. Insulin secretion, β-cell apoptosis, intracellular insulin and leptin mediators, and oxidative stress (OS) markers were also measured in islets isolated from each experimental group...
April 6, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29623757/icariin-a-flavonoid-with-anti-cancer-effects-alleviated-paclitaxel-induced-neuropathic-pain-in-a-sirt1-dependent-manner
#6
Yulong Gui, Jie Zhang, Liang Chen, Shunyuan Duan, Jing Tang, Wei Xu, Aiyuan Li
Background One of the most common side effects of paclitaxel was dosage-dependently painful neuropathy. Various reports indicated that spinal neuroinflammation was involved in paclitaxel-induced neuropathic pain. This study investigated the effect of icariin on paclitaxel-induced neuroinflammation and peripheral neuropathy in rats. Methods Two parts were included in this study. In part one, the effect of icariin on paclitaxel-induced neuropathic pain was investigated. Mechanical thresholds were measured as primary outcomes...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29620267/gastrodin-inhibits-high-glucose%C3%A2-induced-human-retinal-endothelial-cell-apoptosis-by-regulating-the-sirt1-tlr4-nf%C3%A2-%C3%AE%C2%BAbp65-signaling-pathway
#7
Tong-He Zhang, Chun-Mei Huang, Xue Gao, Jia-Wei Wang, Lin-Lin Hao, Qiang Ji
Diabetic retinopathy (DR), one of the most common complications of late‑phase diabetes, is associated with the ectopic apoptosis of microvascular cells. Gastrodin, a phenolic glucoside derived from Gastrodia elata Blume, has been reported to have antioxidant and anti‑inflammation activities. The aim of the present study was to investigate the effects of gastrodin on high glucose (HG)‑induced human retinal endothelial cell (HREC) injury and its underlying mechanism. The results demonstrated that HG induced cell apoptosis in HRECs, which was accompanied by increased levels of reactive oxygen species production...
April 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29618822/combined-maternal-and-postnatal-high-fat-diet-leads-to-metabolic-syndrome-and-is-effectively-reversed-by-resveratrol-a-multiple-organ-study
#8
Jiunn-Ming Sheen, Hong-Ren Yu, You-Lin Tain, Wan-Long Tsai, Mao-Meng Tiao, I-Chun Lin, Ching-Chou Tsai, Yu-Ju Lin, Li-Tung Huang
This study aimed to study the impact of a combination of maternal and post-weaning high-fat diets and whether resveratrol was beneficial. Sprague-Dawley dams were fed either chow or a high-fat diet, before mating, during pregnancy, and into lactation. At weaning, their offspring were randomly fed chow or a high-fat diet. Four experimental groups were generated: CC (maternal/postnatal chow diet), HC (maternal high-fat/postnatal chow diet), CH (maternal chow/postnatal high-fat diet), and HH (maternal/postnatal high-fat diet)...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615114/mecp2-mediated-epigenetic-regulation-in-senescent-endothelial-progenitor-cells
#9
Chunli Wang, Fei Wang, Zhen Li, Qing Cao, Liya Huang, Shuyan Chen
BACKGROUND: Cellular aging may be associated with epigenetics. Methyl-CpG-binding protein 2 (MeCP2) and sirtuin 1 (SIRT1) are two important epigenetic factors. Our former work demonstrated that MeCP2 expression increased and SIRT1 expression decreased in senescent endothelial progenitor cells (EPCs). This article aims to reveal the epigenetic regulation caused by MeCP2 in EPCs and discuss its mechanism. METHODS: Tube formation assay and cell apoptosis detection were used to evaluate the function of senescent EPCs induced by MeCP2 overexpression...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29614706/yoga-and-meditation-based-lifestyle-intervention-increases-neuroplasticity-and-reduces-severity-of-major-depressive-disorder-a-randomized-controlled-trial
#10
Madhuri R Tolahunase, Rajesh Sagar, Muneeb Faiq, Rima Dada
BACKGROUND: Current interventions for major depressive disorder (MDD) are suboptimal, and only one third respond to them on initial treatment. Neuroplasticity theories are the basis for several emerging treatments. Evidence on the impact of yoga, a well-known mind-body intervention, on neuroplasticity in MDD is limited. OBJECTIVES: To determine the effects of 12-week yoga- and meditation- based lifestyle intervention (YMLI) on depression severity and systemic biomarkers of neuroplasticity in adult MDD patients on routine drug treatment...
March 25, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29609691/chrysophanol-ameliorates-high-fat-diet-induced-obesity-and-inflammation-in-neonatal-rats
#11
Jie Zhang, Hua Kang, Lifang Wang, Xiaoyan Zhao
Chrysophanol is a member of the anthraquinone family abundant in rhubarb, a widely used herb for obesity treatment in Traditional Chinese Medicine. Though several studies have indicated numerous features of chrysophanol, no study has yet reported the effect of chrysophanol on juvenile obesity. In this study, we tried to identify the anti-obesity effects of chrysophanol by using high-fat diet (HFD)-induced rats as in vivo models. In HFD rats, chrysophanol treatment decreased body weight, blood glucose and the blood level of triglyceride (TG), and enhanced the level of high-density lipoprotein-cholesterol (HDL-C)...
April 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29595075/epigallocatechin-3-gallate-rich-green-tea-extract-ameliorates-fatty-liver-and-weight-gain-in-mice-fed-a-high-fat-diet-by-activating-the-sirtuin-1-and-amp-activating-protein-kinase-pathway
#12
Ui-Jin Bae, John Park, Il Woon Park, Byung Min Chae, Mi-Ra Oh, Su-Jin Jung, Geon-Seek Ryu, Soo-Wan Chae, Byung-Hyun Park
The prevalence of metabolic diseases has risen globally in parallel with the obesity epidemic over the past few decades. Green tea has been reported to have metabolically beneficial effects on obesity; however, the mechanism by which green tea regulates lipid metabolism is not clearly understood. Male c57BL/6 mice were fed a normal chow diet, a high-fat diet (HFD), or an HFD supplemented with various doses of epigallocatechin gallate-rich green tea extract (GTE) for 12 weeks. GTE supplementation reduced body weight gain, prevented hepatic fat accumulation, decreased hypertriglyceridemia, and improved hyperglycemia and insulin resistance in HFD-fed mice...
March 29, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29593748/high-mobility-group-nucleosome-binding-protein-1-as-endogenous-ligand-induces-innate-immune-tolerance-in-a-tlr4-sirtuin-1-dependent-manner-in-human-blood-peripheral-mononuclear-cells
#13
Rob J W Arts, Po-Kai Huang, De Yang, Leo A B Joosten, Jos W M van der Meer, Joost J Oppenheim, Mihai G Netea, Shih-Chin Cheng
High-mobility group nucleosome-binding protein 1 (HMGN1) functions as a non-histone chromatin-binding protein in the cell nucleus. However, extracellular HMGN1 acts as an endogenous danger-associated inflammatory mediator (also called alarmin ). We demonstrated that HMGN1 not only directly stimulated cytokine production but also had the capacity to induce immune tolerance by a TLR4-dependent pathway, similar to lipopolysaccharide (LPS)-induced tolerance. HMGN1-induced tolerance was accompanied by a metabolic shift associated with the inhibition of the induction of Warburg effect (aerobic glycolysis) and histone deacetylation via Sirtuin-1...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29588426/potential-benefits-of-a-sulfated-resveratrol-derivative-for-topical-application
#14
Marta Correia-da-Silva, Verónica Rocha, Cláudia Marques, Cláudia Deus, Adriana Marques-Carvalho, Paulo Oliveira, Andreia Palmeira, Madalena Pinto, Maria Emília Sousa, José Sousa Lobo, Isabel Almeida
Resveratrol (RSV) is a polyphenolic compound with antioxidant, anti-inflammatory, and anti-aging properties partly associated with sirtuin-1 (SIRT1)-activation in the skin. However, poor water solubility may limit RSV efficacy. This work aimed to clarify the interest of a new synthetic water-soluble RSV derivative (resveratrol glucoside sulfate, RSV-GS) for topical application. Resveratrol glucoside sulfate was synthesized using microwave-assisted sulfation. Cytotoxicity assays were performed with the keratinocyte HaCaT cell line, using MTT reduction, neutral red uptake, Alamar Blue/resazurin reduction, trypan blue exclusion, and measurement of ATP concentration...
March 27, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29578961/sirtuin-1-as-a-potential-therapeutic-target-in-pulmonary-artery-hypertension
#15
Xian Wu Cheng, Megumi Narisawa, Xiongjie Jin, Toyoaki Murohara, Masafumi Kuzuya
No abstract text is available yet for this article.
May 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29574748/sirt1-regulates-nuclear-number-and-domain-size-in-skeletal-muscle-fibers
#16
Jacob A Ross, Yotam Levy, Kristoffer Svensson, Andrew Philp, Simon Schenk, Julien Ochala
Skeletal muscle fibers are giant multinucleated cells wherein individual nuclei govern the protein synthesis in a finite volume of cytoplasm; this is termed the myonuclear domain (MND). The factors that control MND size remain to be defined. In the present study, we studied the contribution of the NAD+ -dependent deacetylase, sirtuin 1 (SIRT1), to the regulation of nuclear number and MND size. For this, we isolated myofibers from mice with tissue-specific inactivation (mKO) or inducible overexpression (imOX) of SIRT1 and analyzed the 3D organisation of myonuclei...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29572511/double-deletion-of-tetraspanins-cd9-and-cd81-in-mice-leads-to-a-syndrome-resembling-accelerated-aging
#17
Yingji Jin, Yoshito Takeda, Yasushi Kondo, Lokesh P Tripathi, Sujin Kang, Hikari Takeshita, Hanako Kuhara, Yohei Maeda, Masayoshi Higashiguchi, Kotaro Miyake, Osamu Morimura, Taro Koba, Yoshitomo Hayama, Shohei Koyama, Kaori Nakanishi, Takeo Iwasaki, Satoshi Tetsumoto, Kazuyuki Tsujino, Muneyoshi Kuroyama, Kota Iwahori, Haruhiko Hirata, Takayuki Takimoto, Mayumi Suzuki, Izumi Nagatomo, Ken Sugimoto, Yuta Fujii, Hiroshi Kida, Kenji Mizuguchi, Mari Ito, Takashi Kijima, Hiromi Rakugi, Eisuke Mekada, Isao Tachibana, Atsushi Kumanogoh
Chronic obstructive pulmonary disease (COPD) has been recently characterized as a disease of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged as key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with a COPD-like phenotype progressively developed a syndrome resembling human aging, including cataracts, hair loss, and atrophy of various organs, including thymus, muscle, and testis, resulting in shorter survival than wild-type (WT) mice...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29571747/cdk5-suppression-blocks-sirt1-degradation-via-the-ubiquitin-proteasome-pathway-in-parkinson-s-disease-models
#18
Qian Zhang, Pei Zhang, Guang-Jian Qi, Zheng Zhang, Feng He, Ze-Xi Lv, Xiang Peng, Hong-Wei Cai, Tong-Xia Li, Xue-Min Wang, Bo Tian
The NAD+ -dependent protein deacetylase sirtuin 1 (SIRT1), a member of the sirtuin family, may have a neuroprotective effect in multiple neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). Many studies have suggested that overexpression-induced or resveratrol-treated activation of SIRT1 could significantly ameliorate several neurodegenerative diseases in mouse models. However, the type of SIRT1, protein expression levels and underlying mechanisms remain unclear, especially in PD...
March 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29564694/differential-gene-expression-of-sirtuins-between-somatotropinomas-and-nonfunctioning-pituitary-adenomas
#19
Isabella P P Grande, Paulo V G H Amorim, Ane Caroline Thé B Freire, Raquel S Jallad, Nina R Musolino, Valter A Cescato, Gilberto O da Silva, Marcello D Bronstein, Ericka B Trarbach
Sirtuins 1-7 (SIRT) are a highly conserved family of histone deacetylases involved in the regulation of longevity that have a considerable impact in transcription, DNA repair regulation, telomeric stability, cell senescence and apoptosis. In the present study, SIRT1-7 mRNA levels were evaluated in 37 somatotropinomas and 31 nonfunctioning pituitary adenomas (NFPAs) using qPCR and relation to tumor size, invasiveness and Ki-67 proliferative index was made. Overexpression of SIRT1 was observed in 86.5% of somatotropinomas versus 41...
March 21, 2018: Pituitary
https://www.readbyqxmd.com/read/29563875/mangiferin-improves-hepatic-lipid-metabolism-mainly-through-its-metabolite-norathyriol-by-modulating-sirt-1-ampk-srebp-1c-signaling
#20
Jian Li, Mengyang Liu, Haiyang Yu, Wei Wang, Lifeng Han, Qian Chen, Jingya Ruan, Shaoshi Wen, Yi Zhang, Tao Wang
Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF is converted to its active metabolite(s), which contributes to the effects on lipid metabolism. Methods: KK-Ay mice were used to validate the effects of MGF on lipid metabolic disorders. Liver biochemical indices and gene expressions were determined. MGF metabolites were isolated from MGF administrated rat urine. Mechanism studies were carried out using HepG2 cells treated by MGF and its metabolite with or without inhibitors or small interfering RNA (siRNA)...
2018: Frontiers in Pharmacology
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