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sirtuin-1

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https://www.readbyqxmd.com/read/27911441/sirt1-protects-the-heart-from-er-stress-induced-cell-death-through-eif2%C3%AE-deacetylation
#1
Alexandre Prola, Julie Pires Da Silva, Arnaud Guilbert, Lola Lecru, Jérôme Piquereau, Maxance Ribeiro, Philippe Mateo, Mélanie Gressette, Dominique Fortin, Céline Boursier, Cindy Gallerne, Anaïs Caillard, Jane-Lise Samuel, Hélène François, David A Sinclair, Pierre Eid, Renée Ventura-Clapier, Anne Garnier, Christophe Lemaire
Over the past decade, endoplasmic reticulum (ER) stress has emerged as an important mechanism involved in the pathogenesis of cardiovascular diseases including heart failure. Cardiac therapy based on ER stress modulation is viewed as a promising avenue toward effective therapies for the diseased heart. Here, we tested whether sirtuin-1 (SIRT1), a NAD(+)-dependent deacetylase, participates in modulating ER stress response in the heart. Using cardiomyocytes and adult-inducible SIRT1 knockout mice, we demonstrate that SIRT1 inhibition or deficiency increases ER stress-induced cardiac injury, whereas activation of SIRT1 by the SIRT1-activating compound STAC-3 is protective...
December 2, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27909015/diabetic-human-adipose-tissue-derived-mesenchymal-stem-cells-fail-to-differentiate-in-functional-adipocytes
#2
Ignazio Barbagallo, Giovanni Li Volti, Fabio Galvano, Guido Tettamanti, Francesca R Pluchinotta, Sonia Bergante, Luca Vanella
Adipose tissue dysfunction represents a hallmark of diabetic patients and is a consequence of the altered homeostasis of this tissue. Mesenchymal stem cells (MSCs) and their differentiation into adipocytes contribute significantly in maintaining the mass and function of adult adipose tissue. The aim of this study was to evaluate the differentiation of MSCs from patients suffering type 2 diabetes (dASC) and how such process results in hyperplasia or rather a stop of adipocyte turnover resulting in hypertrophy of mature adipocytes...
November 30, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27908642/negative-regulation-of-nlrp3-inflammasome-by-sirt1-in-vascular-endothelial-cells
#3
Yanxiang Li, Xiaofeng Yang, Yanhao He, Weirong Wang, Jiye Zhang, Wei Zhang, Ting Jing, Bo Wang, Rong Lin
NLRP3 inflammasome not only functions as a critical effector in innate immunity, but also triggers the production of proinflammatory cytokines involved in inflammation-associated diseases. Sirtuin 1 (SIRT1) plays an important role in the regulation of cellular inflammation. However, whether the activation of NLRP3 inflammasome is regulated by SIRT1 remains unknown. In this study, we investigated the regulatory effect of SIRT1 on NLRP3 inflammasome and the underlying mechanisms. We found that lipopolysaccharide (LPS) and adenosine triphosphate (ATP)-induced the activation of NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)...
November 4, 2016: Immunobiology
https://www.readbyqxmd.com/read/27898652/natural-mineral-rich-water-ingestion-by-ovariectomized-fructose-fed-sprague-dawley-rats-effects-on-sirtuin-1-and-glucocorticoid-signaling-pathways
#4
Jugal Kishore Das, Milton Severo, Cidália Dionísio Pereira, Emília Patrício, José Magalhães, Rosário Monteiro, Delminda Neves, Maria João Martins
OBJECTIVE: Prevention or induction of metabolic disorders and obesity depend on estrogen signaling and/or exogenous factors, such as mineral content in diet. The protective effects of a Portuguese natural mineral-rich water against the induction of metabolic syndrome in fructose-fed male Sprague-Dawley rats have been reported. The present study was designed to assess the impact of this mineral-rich water on fructose-fed estrogen-deficient female Sprague-Dawley rats. METHODS: Ovariectomized rats had access to tap (TWO) or mineral-rich (MWO) waters, with and without 10% fructose (10-wk treatment)...
November 28, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27896651/postnatal-administration-of-dizocilpine-inhibits-neuronal-excitability-in-pfc-and-induces-social-deficits-detected-by-miceprofiler
#5
Dexiao Zhu, Hui Wang, Jintao Wu, Qian Wang, Ling Xu, Yue Zhao, Kunkun Pang, Qingqing Shi, Wenbo Zhao, Jing Zhang, Jinhao Sun
Schizophrenia is a devastating mental disease with social deficit as its core component of negative symptoms, which could be induced in rodents by dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist. NMDA receptors are highly expressed during the postnatal period. However, less attention has been paid to the effects of postnatal MK-801 administration on social interaction. In this study, we evaluated the effects of postnatal administration of MK-801 on social interaction and explored the possible mechanisms...
November 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27878240/sirt1-activator-represses-the-transcription-of-tnf%C3%A2-%C3%AE-in-thp%C3%A2-1-cells-of-a-sepsis-model-via-deacetylation-of-h4k16
#6
Guo-Dong Chen, Wei-Dong Yu, Xiao-Ping Chen
Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, comprising lipopolysaccharide (LPS)‑tolerant THP‑1 cells, was used to investigate whether the SirT1 activator, resveratrol, repressed the transcription of TNF‑α. Chromatin immunoprecipitation and real‑time PCR were used to determine the transcription of the TNF‑α promoter...
November 15, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27878231/sirt1-exerts-neuroprotective-effects-by-attenuating-cerebral-ischemia-reperfusion-induced-injury-via-targeting-p53-microrna-22
#7
Hui Lu, Bincheng Wang
The aim of this study was to investigate whether the SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury (CIRI) via targeting p53/microRNA-22. We found that the overexpression of sirtuin 1 (SIRT1) decreased the infarct volume, suppressed p53 protein expression and activated microRNA-22 expression following CIRI. An injection of lipopolysaccharide (LPS, 1 mg/ml; Sigma, St. Louis, MO USA) into the corpus callosum was used to induce CIRI in rats. The infarct volume and neurological deficit score were used to examine the effects of SIRT1 on CIRI...
November 18, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27875732/sirtuin-1-protects-the-aging-heart-from-contractile-dysfunction-mediated-through-the-inhibition-of-endoplasmic-reticulum-stress-mediated-apoptosis-in-cardiac-specific-sirtuin-1-knockout-mouse-model
#8
Yu-Juei Hsu, Shih-Che Hsu, Chiao-Po Hsu, Yen-Hui Chen, Yung-Lung Chang, Junichi Sadoshima, Shih-Ming Huang, Chien-Sung Tsai, Chih-Yuan Lin
BACKGROUND: The longevity regulator Sirtuin 1 is an NAD(+)-dependent histone deacetylase that regulates endoplasmic reticulum stress and influences cardiomyocyte apoptosis during cardiac contractile dysfunction induced by aging. The mechanism underlying Sirtuin 1 function in cardiac contractile dysfunction related to aging has not been completely elucidated. METHODS: We evaluated cardiac contractile function, endoplasmic reticulum stress, apoptosis, and oxidative stress in 6- and 12month-old cardiac-specific Sirtuin 1 knockout (Sirt1(-/-)) and control (Sirt1(f/f)) mice using western blotting and immunohistochemistry...
November 14, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27871879/aging-aggravates-alcoholic-liver-injury-and-fibrosis-in-mice-by-downregulating-sirtuin-1-expression
#9
Teresa Ramirez, Yong-Mei Li, Shi Yin, Ming-Jiang Xu, Dechun Feng, Zhou Zhou, Mengwei Zang, Partha Mukhopadhyay, Zoltan V Varga, Pal Pacher, Bin Gao, Hua Wang
BACKGROUND AND AIMS: Aging is known to exacerbate the progression of alcoholic liver disease (ALD), but the underlying mechanisms remain obscure. METHODS: C57BL/6 mice were subjected to short-term (10-days) ethanol-plus-one binge or long-term (8-weeks) ethanol-plus-multiple binges of ethanol. Liver injury and fibrosis were determined. Hepatic stellate cells (HSCs) were isolated and used in in vitro studies. RESULTS: Compared to young (8-12 weeks) mice, middle-aged (12-14 months) and old (>16 months) mice were more susceptible to liver injury, inflammation, and oxidative stress induced by short-term-plus-one binge or long-term-plus-multiple binges of ethanol feeding...
November 18, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27865348/nutrient-restriction-of-glucose-or-serum-results-in-similar-proteomic-expression-changes-in-3d-colon-cancer-cell-cultures
#10
Monica M Schroll, Xin Liu, Sarah K Herzog, Susan B Skube, Amanda B Hummon
Nutrient restriction, also known as caloric restriction, has been extensively examined for its positive impact on lifespan, immune system boost, and aging. In addition, nutrient restriction is implicated in decreasing cancer initiation and progression. Given the phenotypic changes associated with nutrient restriction, we hypothesized significant protein expression alterations must be associated with caloric restriction. To compare the molecular and phenotypic changes caused by glucose restriction and fetal bovine serum restriction there is need for an efficient model system...
October 2016: Nutrition Research
https://www.readbyqxmd.com/read/27852610/vascular-endothelium-in-diabetes
#11
Michael S Goligorsky
Three decades ago a revolutionary idea ascribing to dysfunctional endothelia some manifestations of diabetes was born, the Steno hypothesis. Here I briefly outline the accomplishments made in the past 15 years to buttress this hypothesis. Those include development of novel technological platforms to examine microcirculatory beds, deeper understanding of patterns of microvascular derangement in diabetes, pathophysiology of nitric oxide synthesis and availability, nitrosative and oxidative stress in diabetes, premature senescence of endothelial cells and the role of sirtuin 1 and lysosomal dysfunction in this process, state of endothelial glycocalyx and endothelial progenitor cells in diabetes...
November 16, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27847206/the-sirt1-nf-kb-signaling-pathway-is-involved-in-regulation-of-endothelin-type-b-receptors-mediated-by-homocysteine-in-vascular-smooth-muscle-cells
#12
Yulong Chen, Huanhuan Liu, Hongmei Zhang, Enqi Liu, Cang-Bao Xu, Xingli Su
Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases (CVDs). Endothelin type B (ETB) receptors were involved in the pathogenesis of CVDs. However, Sirtuin 1(Sirt1) has potential protect roles for CVDs. The present study was designed to examine the hypothesis that homocysteine up-regulates ETB receptors through down-regulation of Sirt 1. In vitro experiments were performed in rat superior mesenteric artery (SMA). The rat SMA was cultured in serum free medium for 24h in the presence and absence of homocysteine (Hcy) with or without resveroral (Res) (a Sirt 1agonist)...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27846305/time-to-decide-dynamical-analysis-predicts-partial-tip-stalk-patterning-states-arise-during-angiogenesis
#13
Lakshmi Venkatraman, Erzsébet Ravasz Regan, Katie Bentley
Angiogenesis is a highly dynamic morphogenesis process; however, surprisingly little is known about the timing of the different molecular processes involved. Although the role of the VEGF-notch-DLL4 signaling pathway has been established as essential for tip/stalk cell competition during sprouting, the speed and dynamic properties of the underlying process at the individual cell level has not been fully elucidated. In this study, using mathematical modeling we investigate how specific, biologically meaningful, local conditions around and within an individual cell can influence their unique tip/stalk phenotype switching kinetics...
2016: PloS One
https://www.readbyqxmd.com/read/27844208/sirtuins-1-7-expression-in-human-adipose-derived-stem-cells-from-subcutaneous-and-visceral-fat-depots-influence-of-obesity-and-hypoxia
#14
Stefania Mariani, Giuliana Di Rocco, Gabriele Toietta, Matteo A Russo, Elisa Petrangeli, Luisa Salvatori
The sirtuin family comprises seven NAD(+)-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways. Sirtuins are important modulators of adipose tissue metabolism and their expression is higher in lean than obese subjects. At present, the role of sirtuins in adipose-derived stem cells has not been investigated yet. Therefore, in this study, we evaluated the expression of the complete panel of sirtuins in adipose-derived stem cells isolated from both subcutaneous and visceral fat of non-obese and obese subjects...
November 14, 2016: Endocrine
https://www.readbyqxmd.com/read/27836195/design-synthesis-of-allosteric-peptide-activator-for-human-sirt1-and-its-biological-evaluation-in-cellular-model-of-alzheimer-s-disease
#15
Rahul Kumar, Lokesh Nigam, Amrendra Pratap Singh, Kusum Singh, Naidu Subbarao, Sharmistha Dey
Sirtuin 1 (SIRT1) is one of the member of the mammalian proteins of the Sirtuin family of NAD(+) dependent deacetylases, has recently been shown to attenuate amyloidogenic processing of amyloid protein precursor (APP) in in-vitro cell culture studies and transgenic mouse models of Alzheimer's disease (AD). SIRT1 has been shown to have a protective role against (AD). It has been reported earlier that increasing SIRT1 activity can prevent AD in mice model. Tripeptide as an activator of SIRT1 were screened on the basis of structural information by molecular docking and synthesized by solid phase method...
November 3, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27831566/cysteine-cathepsins-control-hepatic-nf-%C3%AE%C2%BAb-dependent-inflammation-via-sirtuin-1-regulation
#16
Álvaro de Mingo, Estefanía de Gregorio, Anna Moles, Núria Tarrats, Anna Tutusaus, Anna Colell, Jose C Fernandez-Checa, Albert Morales, Montserrat Marí
Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF-κB-dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or S, CTSB/S) execute specific functions in physiological processes, such as protein degradation, having SIRT1 as a substrate. We investigated the roles of CTSB/S and SIRT1 in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines. In all cells analyzed, CTSB/S inhibition reduces nuclear p65-NF-κB and κB-dependent gene expression after LPS or TNF through enhanced SIRT1 expression...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27824080/lycium-barbarum-polysaccharide-attenuates-high-fat-diet-induced-hepatic-steatosis-by-up-regulating-sirt1-expression-and-deacetylase-activity
#17
Li Jia, Wang Li, Jianning Li, Yan Li, Hui Song, Yansong Luan, Hui Qi, Lirong Ma, Xiaohong Lu, Yi Yang
In this study, we aimed to investigate the protective effects and underlying mechanism of Lycium barbarum polysaccharide (LBP) on high-fat-induced nonalcoholic fatty liver disease (NAFLD). Recently, sirtuin 1 (SIRT1) has been shown to play an important role in the regulation of hepatocellular lipid metabolism. Here, we demonstrated that LBP up-regulates SIRT1 deacetylase activity and protein expression by enhancing the NAD(+)/NADH ratio. Subsequently, LBP promoted LKB1 deacetylation and AMPK phosphorylation via SIRT1-dependent signalling...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818225/protective-effects-of-srt1720-via-the-hnf1%C3%AE-fxr-signalling-pathway-and-anti-inflammatory-mechanisms-in-mice-with-estrogen-induced-cholestatic-liver-injury
#18
Linxi Yu, Xiaoxin Liu, Xiaojiaoyang Li, Zihang Yuan, Hang Yang, Luyong Zhang, Zhenzhou Jiang
Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase and is a member of the silent information regulator 2 (Sir2) families of proteins (also known as Sirtuins). In the liver, hepatic SIRT1 modulates bile acid metabolism through the regulation of farnesoid X receptor (FXR) expression. FXR is one of the most important nuclear receptors involved in the regulation of bile acid metabolism. SIRT1 modulates the FXR expression at multiple levels, including direct deacetylation of this transcription factor and transcriptional regulation through hepatocyte nuclear factor 1α (HNF1α)...
November 3, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27799874/enhanced-viral-replication-by-cellular-replicative-senescence
#19
Ji-Ae Kim, Rak-Kyun Seong, Ok Sarah Shin
Cellular replicative senescence is a major contributing factor to aging and to the development and progression of aging-associated diseases. In this study, we sought to determine viral replication efficiency of influenza virus (IFV) and Varicella Zoster Virus (VZV) infection in senescent cells. Primary human bronchial epithelial cells (HBE) or human dermal fibroblasts (HDF) were allowed to undergo numbers of passages to induce replicative senescence. Induction of replicative senescence in cells was validated by positive senescence-associated β-galactosidase staining...
October 2016: Immune Network
https://www.readbyqxmd.com/read/27793057/hypermethylation-of-the-hic1-promoter-and-aberrant-expression-of-hic1-sirt1-contribute-to-the-development-of-thyroid-papillary-carcinoma
#20
Wenyi Wu, Liting Zhang, Jianqing Lin, Hanwei Huang, Bai Shi, Xingong Lin, Zhongxin Huang, Chaoyang Wang, Jianlong Qiu, Xiaolong Wei
Hypermethylation leading to the loss of hypermethylated in cancer-1 (HIC1) gene expression occurs in many different types of human cancer. HIC1 is a transcriptional repressor that directly binds to the promoter region of NAD-dependent deacetylase sirtuin-1 (SIRT1). SIRT1 functions in cell growth, is anti-apoptotic, protect neurons, functions in senescence, and regulates energy restriction. Epigenetic modification and dysregulation affecting the HIC1/SIRT1 axis is potentially important for the development of malignancies...
October 26, 2016: Oncotarget
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