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https://www.readbyqxmd.com/read/29331311/prediction-of-mortality-in-patients-with-chronic-obstructive-pulmonary-disease-with-the-new-global-initiative-for-chronic-obstructive-lung-disease-2017-classification-a-cohort-study
#1
Anne Gedebjerg, Szimonetta Komjáthiné Szépligeti, Laura-Maria Holm Wackerhausen, Erzsébet Horváth-Puhó, Ronald Dahl, Jens Georg Hansen, Henrik Toft Sørensen, Mette Nørgaard, Peter Lange, Reimar Wernich Thomsen
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 classification separates the spirometric 1-4 staging from the ABCD groups defined by symptoms and exacerbations. Little is known about how this new classification predicts mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to establish the predictive ability of the GOLD 2017 classification, compared with earlier classifications, for all-cause and respiratory mortality, both when using its main ABCD groups and when further subdividing according to spirometric 1-4 staging...
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29328109/distortion-compensated-multifocusing-of-ultrashort-pulse-beams-using-cascade-optical-system
#2
Jun Amako, Hidetoshi Nakano
We report a cascade optical system for multifocusing ultrashort pulse beams, particularly sub-50-fs pulses. System achromaticity is key to simultaneous compensation of the spatio-temporal pulse distortions. In this system, diffractive and refractive subsystems are optically coupled in cascade to correct chromatic aberrations, which are the primary cause of pulse distortion. We design a prototype system by applying achromatic conditions derived from an ABCD matrix analysis. The designed system is then evaluated using 20-fs pulses, by characterizing the transmitted pulses in terms of beam width and pulse duration; hence, the proposed distortion compensation scheme is validated...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29315130/ultrasound-identification-of-diaphragm-by-novices-using-abcde-technique
#3
Jaasmit Khurana, Stephanie C Gartner, Latha Naik, Ban C H Tsui
BACKGROUND AND OBJECTIVES: In this study, we examined the consistency, rapidity, and reproducibility of the ABCDE technique for diaphragm identification. Operators using this method place the probe at the Anterior axillary line, watch for Breathing (lung sliding), and then move the probe Caudally to identify the Diaphragm for Examination. METHODS: A convenience sample of 100 patients was recruited from the preadmission clinic. Two novice operators each scanned the diaphragm using a linear ultrasound transducer in B-mode...
January 9, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29310648/ethnicity-and-socioeconomic-status-are-related-to-dietary-patterns-at-age-5-in-the-amsterdam-born-children-and-their-development-abcd-cohort
#4
Viyan Rashid, Marielle F Engberink, Manon van Eijsden, Mary Nicolaou, Louise H Dekker, Arnoud P Verhoeff, Peter J M Weijs
BACKGROUND: Health inequalities are already present at young age and tend to vary with ethnicity and socioeconomic status (SES). Diet is a major determinant of overweight, and studying dietary patterns as a whole in relation to overweight rather than single nutrients or foods has been suggested. We derived dietary patterns at age 5 and determined whether ethnicity and SES were both related to these dietary patterns. METHODS: We analysed 2769 validated Food Frequency Questionnaires filled in by mothers of children (5...
January 8, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29244967/diagnosis-and-treatment-of-chronic-wounds-current-standards-of-germany-s-initiative-for-chronic-wounds-e-v
#5
J Dissemond, A Bültemann, V Gerber, B Jäger, K Kröger, C Münter
The diagnosis and treatment of patients with chronic wounds is an enormous challenge in various disciplines of medicine. These very complex processes usually involve several experts of different medical specialties with varying educational backgrounds. A necessary basis for consistent communication and documentation is the use of unambiguous nomenclature. Therefore, the board of the German wound association, Initiative for Chronic Wounds (ICW) e.V., has started to define various terms and procedures. An easy to remember algorithm, in the form of the ABCDE rule, has been developed for the structured diagnosis of chronic wounds...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29240902/dose-dependency-and-a-functional-cut-off-for-tpo-antibody-positivity-during-pregnancy
#6
Tim I M Korevaar, Victor J Pop, Layal Chaker, Mariette Goddijn, Yolanda B de Rijke, Peter H Bisschop, Maarten A Broeren, Vincent W V Jaddoe, Marco Medici, Theo J Visser, Eric A P Steegers, Tanja G Vrijkotte, Robin P Peeters
Objective: To investigate a dose-dependency of TPOAb concentrations in relation to thyroid function and premature delivery, and define a population-based, pregnancy-specific, functional cut-off for TPOAb positivity. Design: Individual participant meta-analysis of three prospective birth cohorts (Generation R, ABCD study and HAPPY study). Setting: Population-based studies in the Netherlands (2002-2014). Participants: 11 212 pregnant women (<20 weeks)...
December 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29232148/synthesis-of-the-tetracyclic-structure-of-batrachotoxin-enabled-by-bridgehead-radical-coupling-and-pd-ni-promoted-ullmann-reaction
#7
Komei Sakata, Yinghua Wang, Daisuke Urabe, Masayuki Inoue
The steroidal ABCD-ring system of the potent neurotoxin batrachotoxin was efficiently assembled in a convergent fashion. Bridgehead radical coupling between the simple AB-ring and D-ring fragments (3 and 4) formed the sterically congested linkage at the C9-oxygen-attached tetrasubstituted carbon. The C-ring was then cyclized by the Pd/Ni-promoted Ullmann reaction of the vinyl triflate and vinyl bromide of 19, giving rise to tetracyclic structure 1.
December 12, 2017: Organic Letters
https://www.readbyqxmd.com/read/29230274/factors-influencing-pharmacological-treatment-in-copd-a-comparison-of-2005-and-2014
#8
Josefin Sundh, Joakim Åberg, Mikael Hasselgren, Scott Montgomery, Björn Ställberg, Karin Lisspers, Christer Janson
Introduction: The aim was to investigate how the pattern of pharmacological treatment in Swedish patients with chronic obstructive pulmonary disease (COPD) has changed over a decade, and to identify factors associated with treatment. Methods: Data on patient characteristics and pharmacological treatment were collected using questionnaires from two separate cohorts of randomly selected primary and secondary care patients with a doctor's diagnosis of COPD in central Sweden, in 2005 (n = 1111) and 2014 (n = 1329)...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29222401/genetics-of-floral-development-by-christine-fleet
#9
(no author information available yet)
Summaryplantcell;29/11/tpc.117.tt1117/FIG1F1fig1A basic model for floral organ identity has been developed using model systems such as Arabidopsis thaliana, snapdragon (Antirrhinum majus), and petunia (Petunia hybrida). In this model, different combinations of proteins known as ABCDE proteins, mostly MADS-domain transcription factors, activate the transcription of target genes to specify the identity of each whorl of floral organs. Changes in the regulation or activation of these target genes contribute to the wide variety of floral forms that we see within and across species...
November 2017: Plant Cell
https://www.readbyqxmd.com/read/29221827/prevalence-of-copd-in-6-urban-clusters-in-argentina-the-epoc-ar-study
#10
Andrés L Echazarreta, Sergio J Arias, Ricardo Del Olmo, Eduardo R Giugno, Federico D Colodenco, Santiago C Arce, Juan C Bossio, Gustavo Armando, Joan B Soriano
INTRODUCTION: The prevalence of chronic obstructive pulmonary disease (COPD) has not been studied in Argentina. OBJECTIVES: To determine the prevalence and relevant clinical characteristics of COPD in a representative sample. MATERIAL AND METHODS: We performed a cross-sectional study in a population of adults aged ≥ 40 years randomly selected by cluster sampling in 6 urban locations. Subjects answered a structured survey and performed pre- and post-bronchodilator spirometry (PBD)...
December 5, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29216336/managing-diabetic-kidney-disease
#11
Sagen Zac-Varghese, Peter Winocour
Introduction: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD). This review covers the pillars of care essential for the management of diabetic kidney disease (DKD) including (1) early diagnosis, (2) improved glycaemic control, (3) treatment of hypertension, (4) identification and treatment of associated metabolic bone disease and (5) identification and effective management of dyslipidaemia and additional cardiovascular risk factors. Sources of data: We searched PubMed for articles using search terms: diabetic nephropathy, diabetic kidney disease, diabetes and chronic kidney disease...
December 5, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29185642/using-the-abcde-approach-to-assess-the-deteriorating-patient
#12
Duncan Smith, Tracey Bowden
Patients who deteriorate without recognition or timely interventions are at risk of critical care admission and increased morbidity or mortality. This article outlines the systematic ABCDE (airway, breathing, circulation, disability, exposure) approach to patient assessment, which enables healthcare practitioners to identify and respond to life-threatening conditions in order of priority. The patient's vital signs should be measured as part of the ABCDE assessment and recorded using a track and trigger tool to enhance recognition of physiological abnormalities that signal deterioration...
November 29, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29180629/transcriptome-profile-analysis-reveals-the-regulation-mechanism-of-floral-sex-differentiation-in-jatropha-curcas-l
#13
Wenkai Hui, Yuantong Yang, Guojiang Wu, Changcao Peng, Xiaoyang Chen, Mohamed Zaky Zayed
The seeds of Jatropha curcas contain a high percentage of biodiesel. However, low seed yield which was limited by its poor female flowers was a bottleneck for its utilization. Here, we compared the transcriptomic profiles of five different samples during floral sex differentiation stages using Illumina Hiseq 4000. Our results showed that hundreds of differentially expressed genes (DEGs) were detected in floral sex initiation period, but thousands of DEGs were involved in the stamens and ovules development process...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29180316/dermoscopy-and-confocal-microscopy-for-metachronous-multiple-melanomas-morphological-clinical-and-molecular-correlations
#14
Maria Colombino, Panagiotis Paliogiannis, Calogero Pagliarello, Antonio Cossu, Amelia Lissia, Rosanna Satta, Laura Mazzoni, Serena Magi, Maria Cristina Sini, Antonella Manca, Milena Casula, Valentina Doneddu, Giuseppe Palmieri, Ignazio Stanganelli
Cutaneous melanoma is one of the most frequent malignancies of the skin in Caucasian populations. Patients who develop cutaneous melanoma are at increased risk of developing a second primary melanoma. The estimated incidence of multiple primary melanoma (MPM) ranges from 1.2% to 8.2% of cases, with a high preponderance of melanomas occurring metachronously. The aim of this study was to describe dermoscopic, microscopic, clinical, and molecular correlations between first and subsequent melanomas in patients with metachronous MPMs...
November 27, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29169198/-changes-in-sense-of-coherence-mental-distress-and-satisfaction-with-life-and-studies-in-the-course-of-psychosocial-counselling
#15
Asimina Koutsoukou-Argyraki, Alina Bertolino, Volker Kreß, Frank-Hagen Hofmann, Michael Sperth, Rainer Matthias Holm-Hadulla
"Sense of coherence" (SOC) plays an essential role in the maintenance or recovery of health, according to the salutogenetic approach of Aaron Antonovsky. Empirical studies provide evidence of significant links between sense of coherence and different indicators of mental health. In the present study, the effectivity of an integrative counselling concept for the promotion of sense of coherence, reduction of mental distress and improvement of satisfaction with life was tested in a sample of 153 clients and patients...
November 23, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29150307/approaching-retention-within-the-adolescent-brain-cognitive-development-study
#16
REVIEW
Sarah W Feldstein Ewing, Linda Chang, Linda B Cottler, Susan F Tapert, Gayathri J Dowling, Sandra A Brown
Retention efforts are critical to maintain relationships with research participants over time. This is especially important for the Adolescent Brain Cognitive Development (ABCD) study, where families are asked to stay engaged with the study throughout the course of 10 years. This high-degree of involvement is essential to longitudinally track child and adolescent development. At a minimum, we will connect with families every 6 months by telephone, and every year in person, with closer contact with the youth directly as they transition into adolescence...
November 11, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29145589/the-abcds-of-pain-management-a-double-blind-randomized-controlled-trial-examining-the-impact-of-a-brief-educational-video-on-infants-and-toddlers-pain-scores-and-parent-soothing-behavior
#17
Rebecca Pillai Riddell, Monica C O'Neill, Lauren Campbell, Anna Taddio, Saul Greenberg, Hartley Garfield
Objectives: To test the efficacy of a brief behavioral pain management strategy (The ABCDs of Needle Pain Management), delivered via video, on infants' and toddlers' pain scores and on parental soothing behavior. Methods: This was a double-blind, parallel trial design. Parent-child dyads (N = 128) were recruited before their child's 6-month (infant) or 18-month (toddler) vaccination in a pediatric clinic and randomly assigned to watch a 5-min treatment video or a placebo video...
November 14, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29127102/algorithms-to-guide-ambulance-clinicians-in-the-management-of-emergencies-in-patients-with-implanted-rotary-left-ventricular-assist-devices
#18
REVIEW
Christopher T Bowles, Rachel Hards, Neil Wrightson, Paul Lincoln, Shishir Kore, Laura Marley, Jonathan R Dalzell, Binu Raj, Tracey A Baker, Diane Goodwin, Petra Carroll, Jane Pateman, John J M Black, Paul Kattenhorn, Mark Faulkner, Jayan Parameshwar, Charles Butcher, Mark Mason, Alexander Rosenberg, Ian McGovern, Alexander Weymann, Carl Gwinnutt, Nicholas R Banner, Stephan Schueler, Andre R Simon, David W Pitcher
Advances in left ventricular assist device (LVAD) therapy have resulted in increasing numbers of adult LVAD recipients in the community. However, device failure, stroke, bleeding, LVAD thrombosis and systemic infection can be life-threatening emergencies. Currently, four LVAD systems are implanted in six UK transplant centres, each of which provides device-specific information to local emergency services. This has resulted in inconsistent availability and content of information with the risks of delayed or inappropriate decision-making...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29121518/genome-wide-identification-phylogenetic-analysis-and-expression-profiles-of-atp-binding-cassette-transporter-genes-in-the-oriental-fruit-fly-bactrocera-dorsalis-hendel-diptera-tephritidae
#19
Lin-Fan Xiao, Wei Zhang, Tian-Xing Jing, Meng-Yi Zhang, Ze-Qing Miao, Dan-Dan Wei, Guo-Rui Yuan, Jin-Jun Wang
The ATP-binding cassette (ABC) is the largest transporter gene family and the genes play key roles in xenobiotic resistance, metabolism, and development of all phyla. However, the specific functions of ABC gene families in insects is unclear. We report a genome-wide identification, phylogenetic, and transcriptional analysis of the ABC genes in the oriental fruit fly, Bactrocera dorsalis (Hendel). We identified a total of 47 ABC genes (BdABCs) from the transcriptomic and genomic databases of B. dorsalis and classified these genes into eight subfamilies (A-H), including 7 ABCAs, 7 ABCBs, 9 ABCCs, 2 ABCDs, 1 ABCE, 3 ABCFs, 15 ABCGs, and 3 ABCHs...
October 10, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29113758/demographic-physical-and-mental-health-assessments-in-the-adolescent-brain-and-cognitive-development-study-rationale-and-description
#20
REVIEW
Deanna M Barch, Matthew D Albaugh, Shelli Avenevoli, Linda Chang, Duncan B Clark, Meyer D Glantz, James J Hudziak, Terry L Jernigan, Susan F Tapert, Debbie Yurgelun-Todd, Nelly Alia-Klein, Alexandra S Potter, Martin P Paulus, Devin Prouty, Robert A Zucker, Kenneth J Sher
The Adolescent Brain and Cognitive Development (ABCD) Study incorporates a comprehensive range of measures assessing predictors and outcomes related to both mental and physical health across childhood and adolescence. The workgroup developed a battery that would assess a comprehensive range of domains that address study aims while minimizing participant and family burden. We review the major considerations that went into deciding what constructs to cover in the demographics, physical health and mental health domains, as well as the process of selecting measures, piloting and refining the originally proposed battery...
November 3, 2017: Developmental Cognitive Neuroscience
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