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https://www.readbyqxmd.com/read/28927251/fecal-microbiota-transplantation-past-present-and-future-perspectives
#1
Stefano Bibbò, Gianluca Ianiro, Antonio Gasbarrini, Giovanni Cammarota
Gut microbiota is known to play a main role in regulating both health and disease in humans. Strategies for the therapeutic modulation of gut microbiota are therefore expected to give a relevant contribution in the management of disorders associated with its impairment. Among these options, one of the most renowned is fecal microbiota transplantation (FMT). A growing body of evidence showed clearly that FMT is an effective treatment against recurrent Clostridium difficile infection. Moreover, it was shown to be a promising therapy for the management of several noncommunicable disorders, including inflammatory bowel diseases and metabolic disorders...
December 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28927245/calcium-homeostasis-in-diabetes-mellitus
#2
REVIEW
Changhwan Ahn, Ji-Houn Kang, Eui-Bae Jeung
Diabetes mellitus (DM) is becoming a lifestyle-related pandemic disease. Diabetic patients frequently develop electrolyte disorders, especially diabetic ketoacidosis or nonketotic hyperglycemic hyperosmolar syndrome. Such patients show characteristic potassium, magnesium, phosphate, and calcium depletion. In this review, we discuss a homeostatic mechanism that links calcium and DM. We also provide a synthesis of the evidence in favor or against this linking mechanism by presenting recent clinical indications, mainly from veterinary research...
September 30, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28927213/ten-step-minimally-invasive-spine-lumbar-decompression-and-dural-repair-through-tubular-retractors
#3
Mohamed Abdelatif Boukebir, Connor David Berlin, Rodrigo Navarro-Ramirez, Tim Heiland, Karsten Schöller, Cameron Rawanduzy, Sertaç Kirnaz, Ajit Jada, Roger Härtl
BACKGROUND: Minimally invasive spine (MIS) surgery utilizing tubular retractors has become an increasingly popular approach for decompression in the lumbar spine. However, a better understanding of appropriate indications, efficacious surgical techniques, limitations, and complication management is required to effectively teach the procedure and to facilitate the learning curve. OBJECTIVE: To describe our experience and recommendations regarding tubular surgery for lumbar disc herniations, foraminal compression with unilateral radiculopathy, lumbar spinal stenosis, synovial cysts, and dural repair...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926864/-thermochemotherapy-with-mitomycin-c-an-update-on-alternative-treatment-strategies-in-non-muscleinvasive-bladder-cancer
#4
Frank Christoph, Frank König, Stefan Lebentrau, Simon Blaschke, Uwe-Bernd Liehr, Martin Schostak
Bladder cancer is the second most common urological malignant disease. There are various treatment strategies which, depending on tumor stage and grade, can minimize recurrence and lower progression rate. Alternative treatment modalities of instillation therapy after failure with first line Mitomycin C or BCG do exist and have become a point of interest, especially in times of shortage of agents such as BCG.This article aims to give an overview of the current existing thermotherapeutic treatment options (electroinductive and electroconductive)...
September 19, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28926161/neural-basis-of-major-depression-beyond-monoamine-hypothesis
#5
Shuken Boku, Shin Nakagawa, Hiroyuki Toda, Akitoyo Hishimoto
Monoamine hypothesis has been accepted as the most common hypothesis of major depression for a long period because of its simplicity and understandability. Actually, most of currently used antidepressants have been considered to act based on monoamine hypothesis. However, it has been pointed out as an important problem of monoamine hypothesis that it is unable to explain the latency of response to antidepressants. In addition, a large number of patients with major depression has been refractory to currently used antidepressants yet...
September 19, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28926026/conceptual-models-underlying-economic-analysis-of-animal-health-and-welfare-with-the-inclusion-of-three-components-people-products-and-resources
#6
D A Hennessy
Infectious animal diseases can spill across farm boundaries, so effective management requires coordinated responses. Costs and benefits from the management of infectious diseases are such that those who make the decisions have weak incentives to act, the levels of goods and services produced from animal agriculture are probably smaller than is socially optimal and resources are likely wasted. This work provides an overview of the existing literature on conceptual economic models in animal disease management, paying particular attention to inadequate incentives to make the required biosecurity efforts...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925961/towards-an-ultrasonic-guided-wave-procedure-for-health-monitoring-of-composite-vessels-application-to-hydrogen-powered-aircraft
#7
Slah Yaacoubi, Peter McKeon, Weina Ke, Nico F Declercq, Fethi Dahmene
This paper presents an overview and description of the approach to be used to investigate the behavior and the defect sensitivity of various ultrasonic guided wave (UGW) modes propagating specifically in composite cylindrical vessels in the framework of the safety of hydrogen energy transportation such as hydrogen-powered aircrafts. These structures which consist of thick and multi-layer composites are envisioned for housing hydrogen gas at high pressures. Due to safety concerns associated with a weakened structure, structural health monitoring techniques are needed...
September 19, 2017: Materials
https://www.readbyqxmd.com/read/28925902/adipose-triglyceride-lipase-regulation-an-overview
#8
Ines Katrin Cerk, Lisa Wechselberger, Monika Oberer
Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production. There is growing evidence that the products and intermediates from lipolytic breakdown during the FA mobilization process also have fundamental regulatory functions affecting cell signaling, gene expression, metabolism, cell growth, cell death, and lipotoxicity. Regulation of ATGL is therefore vital for maintaining a defined balance between lipid storage and mobilization...
September 18, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28925896/allopurinol-old-drug-new-indication-in-neonates
#9
Kim V Annink, Axel R Franz, Jan B Derks, Mario Rüdiger, Frank van Bel, Manon J N L Benders
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is an important cause of neonatal mortality and neurological morbidity, even despite hypothermia treatment. Neuronal damage in these infants is partly caused by the production of superoxides via the xanthine-oxidase pathway and concomitant free radical formation. Allopurinol is a xanthine-oxidase inhibitor and can potentially reduce the formation of these superoxides that lead to brain damage in HIE. METHODS: The aim of this review is to provide an overview of the animal and clinical data about the neuroprotective effect of allopurinol in HIE and the relevant mechanisms leading to brain injury in HIE...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925890/the-use-of-hemodynamic-and-cerebral-monitoring-to-study-pharmacodynamics-in-neonates
#10
A Smits, L Thewissen, A Dereymaeker, E Dempsey, A Caicedo, Gunnar Naulaers
BACKGROUND: Drugs acting on the cardiovascular and central nervous system often display relatively fast clinical responses, which may differ in neonates compared to children and adults. Introduction of bedside monitoring tools might be of additional value in the pharmacodynamic (PD) assessment of such drugs in neonates. METHODS: We aim to provide an overview of the frequently used monitoring tools to assess drug effects on the hemodynamic status as well as the cerebral circulation, oxygenation and cerebral metabolism in neonates...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925883/novel-therapeutics-in-glaucoma-management
#11
Claudio Bucolo, Chiara Bianca Maria Platania, Filippo Drago, Michele Reibaldi, Vincenza Bonfiglio, Teresio Avitabile, Maurizio Uva
Glaucoma is a progressive optic neuropathy characterized by retinal ganglion cell death and alterations of visual field. Elevated intraocular pressure (IOP) is considered the main risk factor of glaucoma, even though other factors cannot be ruled out, such as epigenetic mechanisms. An overview of the ultimate promising experimental drugs to manage glaucoma has been provided. In particular, we have focused on purinergic ligands, KATP channel activators, gases (nitric oxide, carbon monoxide and hydrogen sulfide), non-glucocorticoid steroidal compounds, neurotrophic factors, PI3K/Akt activators, citicoline, histone deacetylase inhibitors, cannabinoids, dopamine and serotonin receptors ligands, small interference RNA, and Rho kinase inhibitors...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28925724/pistachio-nut-allergy-an-updated-overview
#12
Joana Costa, Isa Silva, António A Vicente, M Beatriz P P Oliveira, Isabel Mafra
Pistachio nut (Pistacia vera) is highly appreciated for its organoleptic characteristics and potential health benefits. However, this tree nut is also responsible for triggering moderate to severe IgE-mediated reactions in allergic individuals. Currently, pistachio nut allergy has gained some special attention, mainly due to its intrinsic relation with cashew nut allergy. Like for other nuts, the prevalence of pistachio nut allergy seems to be increasing at a global scale. Until now, there are five allergenic proteins officially listed for pistachio nut (Pis v 1, Pis v 2, Pis v 3, Pis v 4 and Pis v 5)...
September 19, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28925607/the-2017-medicare-physician-fee-schedule-an-overview-of-provisions-that-will-affect-surgical-practice
#13
Lauren Foe, Jan Nagle, Vinita Ollapally
No abstract text is available yet for this article.
January 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28925275/-catamenial-pneumothorax-case-reports-and-literature-review
#14
E Voláková, V Kolek, J Kufa, J Zatloukal, J Chudáček, M Szkorupa, R Pilka
AIM: Catamenial pneumothorax is menstrual cycle dependent and represents the most common form of thoracic endometriosis syndrome. Recurrences are very common even after surgical resection. DESIGN: Case reports and literature overview. SETTING: Department of Respiratory Medicine, Department of Surgery I, Department of Obstetrics and Gynecology, University Hospital, Palacky University, Olomouc. CASE REPORT: Two cases of catamenial pneumothorax are presented with repeated recurrences of right-sided pneumothorax even after surgical treatment...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28925273/-current-trends-in-gamete-donation-psychosocial-and-ethical-issues
#15
T Rumpíková, I Oborná, H Konečná
OBJECTIVE: To overview contemporary knowledge of legal and psychosocial rules in gamete donation. Previously, anonymous donation was preferred and recommended by experts but currently, with respect to the right to know the genetic origin of individuals, the relation to donor anonymity was reconsidered in many countries. There is a growing tendency to introduce the open identity system in gamete donation. Such system may guarantee that the child born after gamete donation may have receive the identification data of the donor of gametes...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28925070/the-fructan-syndrome-evolutionary-aspects-and-common-themes-among-plants-and-microbes
#16
REVIEW
Maxime Versluys, Onur Kirtel, Ebru Toksoy Öner, Wim Van den Ende
Fructans are multifunctional fructose-based water soluble carbohydrates found in all biological kingdoms but not in animals. Most research has focused on plant- and microbial fructans and has received a growing interest because of their practical applications. Nevertheless, the origin of fructan production, the so-called 'fructan syndrome', is still unknown. Why fructans only occur in a limited number of plant and microbial species remains unclear. In this review, we provide an overview of plant and microbial fructan research with a focus on fructans as an adaptation to the environment and their role in (a)biotic stress tolerance...
September 18, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28925019/inclusion-of-pregnant-and-breastfeeding-women-in-research-efforts-and-initiatives
#17
Sílvia M Illamola, Christina Bucci-Rechtweg, Maged M Costantine, Katerina Tsilou, Catherine M Sherwin, Anne Zajicek
Pregnant and breastfeeding women have been rendered therapeutic orphans as they have been historically excluded from clinical trials. Labeling for most approved drugs does not provide information about safety and efficacy during pregnancy. This lack of data is mainly due to ethico-legal challenges that have remained entrenched in the post-diethylstilbestrol and thalidomide era, and that have led to pregnancy being viewed in the clinical trial setting primarily through a pharmacovigilance lens. Policy considerations that encourage and/or require the inclusion of pregnant or lactating women in clinical trials may address the current lack of available information...
September 19, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28924872/-alzheimer-s-disease-from-auguste-deter-to-the-present-progress-disappointments-and-open-questions
#18
REVIEW
Johannes Pantel
AIM: The present article aims to provide a short overview of the discovery history, conceptual development, as well as on current neurobiological and pharmacological research questions in the field of Alzheimer's disease (AD). In view of the long hoped for but so far unachieved therapeutic breakthrough, this also includes a critical reflection of current research paradigms. MATERIAL AND METHODS: Starting from the first case report described by Alois Alzheimer in 1906, the historical impact of his seminal discovery is reconstructed...
September 18, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28924687/comskil-communication-training-in-oncology-adaptation-to-german-cancer-care-settings
#19
Tim J Hartung, David Kissane, Anja Mehnert
Medical communication is a skill which can be learned and taught and which can substantially improve treatment outcomes, especially if patients' communication preferences are taken into account. Here, we give an overview of communication training research and outline the COMSKIL program as a state-of-the-art communication skills training in oncology. COMSKIL has a solid theoretical foundation and teaches core elements of medical communication in up to ten fully operationalized modules. These address typical situations ranging from breaking bad news to responding to difficult emotions, shared decision-making, and communicating via interpreters...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28924658/two-photon-sted-microscopy-for-nanoscale-imaging-of-neural-morphology-in-vivo
#20
Mirelle J T Ter Veer, Thomas Pfeiffer, U Valentin Nägerl
The advent of super-resolution microscopy offers to bridge the gap between electron and light microscopy. It has opened up the possibility of visualizing cellular structures and dynamic signaling events on the "mesoscale" well below the classic diffraction barrier of light microscopy (10-200 nm), while essentially retaining the advantages of fluorescence microscopy concerning multicolor labeling, detection sensitivity, signal contrast, live-cell imaging, and temporal resolution.From among the new super-resolution techniques, STED microscopy stands out as a laser-scanning imaging modality, which enables nanoscale volume-metric imaging of cellular morphology...
2017: Methods in Molecular Biology
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