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https://www.readbyqxmd.com/read/28432684/characterization-of-interactions-of-metal-containing-nanoparticles-with-biomolecules-by-ce-an-update-2012-2016
#1
REVIEW
Svetlana S Aleksenko, Magdalena Matczuk, Andrei R Timerbaev
The methodological developments and applications of CE related to studying biotransformations of metal-based nanoscale particles of impending medicinal use are overviewed. This is an update to a previous review article (Aleksenko, S. S., Shmykov, A. Y., Oszwałdowski, S., Timerbaev, A. R., Metallomics 2012, 4, 1141-1148) and it covers the research papers published within the last five years. As was anticipated in that review, CE can now be seen as a customary technique in the analysis of biomolecular interactions that exert an impact on the mechanism of action of nanoparticles, comprising metabolism, delivery, cell processing, and targeting...
April 22, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28432500/walking-over-4-gya-chemical-evolution-from-photochemistry-to-mineral-and-organic-chemistries-leading-to-an-rna-world
#2
REVIEW
Kunio Kawamura, Marie-Christine Maurel
Here we overview the chemical evolution of RNA molecules from inorganic material through mineral-mediated RNA formation compatible with the plausible early Earth environments. Pathways from the gas-phase reaction to the formation of nucleotides, activation and oligomerization of nucleotides, seem to be compatible with specific environments. However, how these steps interacted is not clear since the chemical conditions are frequently different and can be incompatible between them; thus the products would have migrated from one place to another, suitable for further chemical evolution...
April 21, 2017: Origins of Life and Evolution of the Biosphere
https://www.readbyqxmd.com/read/28432467/renal-skin-syndromes
#3
REVIEW
Cristina Has, Yinghong He
Renal-skin syndroms are a group of genetic disorders with renal and cutaneous manifestations that target molecular components present in both organs. Inherited renal-skin syndromes are mainly associated with defects of cell-matrix adhesion. We provide a non-exhaustive overview of the main molecular players at cell-matrix adhesions in mouse models and in human genetic disorders affecting kidney and skin. Renal and urinary tract involvement is described in all four major epidermolysis bullosa types and, in particular, in junctional subtypes and in recessive dystrophic epidermolysis bullosa...
April 22, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28432390/biomass-resources-agriculture
#4
Ingeborg N Kluts, Marnix L J Brinkman, Sierk A de Jong, H Martin Junginger
Bioenergy is the single largest source of renewable energy in the European Union (EU-28); of this, 14% was produced from agricultural feedstocks in 2012. This chapter provides an overview of the current use (for bioenergy) and future potential of agricultural feedstocks for (amongst others) biorefinery purposes in the European Union. The main application of these feedstocks is currently the production of biofuels for road transport. Biodiesel makes up 80% of the European biofuel production, mainly from rapeseed oil, and the remaining part is bioethanol from wheat and sugar beet...
April 22, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28432221/biological-considerations-of-plasma-derived-and-recombinant-factor-viii-immunogenicity
#5
Jesse Lai, Christine Hough, Julie Tarrant, David Lillicrap
In hemophilia A, the most severe complication of factor VIII (FVIII) replacement therapy involves the formation of FVIII neutralizing antibodies, also known as inhibitors, in 25-30% of patients. This adverse event is associated with a significant increase in morbidity and economic burden, thus highlighting the need to identify methods to limit FVIII immunogenicity. Inhibitor development is regulated by a complex balance of genetic factors, such as FVIII genotype, and environmental variables, such as coexistent inflammation...
April 21, 2017: Blood
https://www.readbyqxmd.com/read/28432132/do-memory-cd4-t-cells-keep-their-cell-type-programming-plasticity-versus-fate-commitment-epigenome-a-dynamic-vehicle-for-transmitting-and-recording-cytokine-signaling
#6
John L Johnson, Golnaz Vahedi
CD4(+) T cells are critical for the elimination of an immense array of microbial pathogens. Although there are aspects of helper T-cell differentiation that can be modeled as a classic cell-fate commitment, CD4(+) T cells also maintain considerable flexibility in their transcriptional program. Here, we present an overview of chromatin biology during cellular reprogramming and, within this context, envision how the scope of cellular reprogramming may be expanded to further our understanding of the controversy surrounding CD4(+) T lymphocyte plasticity or determinism...
April 21, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28431780/tolterodine-tartrate
#7
Gennady Ananchenko, Jasmina Novakovic
Tolterodine tartrate belongs to the family of muscarinic receptor antagonists and is indicated for the treatment of overactive urinary bladder syndrome. This chapter provides an overview of physical, analytical, and ADME profiles; highlights methods of chemical synthesis; and discusses stability of tolterodine as a free base and/or its l-tartrate salt in solution and in the solid state. The information presented in this chapter is based on the peer-reviewed literature, compendial reports (USP, EP), and authors' data...
2017: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/28431687/a-rapid-impregnation-method-for-loading-desired-amounts-of-extractant-on-prepacked-reversed-phase-columns-for-high-performance-liquid-chromatographic-separation-of-metal-ions
#8
Muhammad Ramzan, Dejene Kifle, Grethe Wibetoe
A time-efficient impregnation method for loading extractant onto reversed-phase columns was developed, using di-(2-ethylhexyl) phosphoric acid (HDEHP) as a model extractant. The optimal loading conditions for the impregnation process of a standard analytical scale column was achieved by dissolving an appropriate amount of HDEHP (per void volume) in n-pentane, flushing the column with two void volumes (5mL) of impregnation solution and heating the column for a short time to remove the solvent. The process takes about one hour, a significant time reduction compared to commonly used impregnation methods (17-23h)...
April 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28431639/advances-in-molecular-diagnosis-of-malaria
#9
Zhi Zheng, Zhibin Cheng
Malaria is a mosquito-borne disease caused by five species of Plasmodium parasites. Accurate diagnosis of malaria plays an essential part in malaria control. With traditional diagnostic methodologies, malaria control programs have achieved remarkable success during the past decade, and are now heading toward malaria elimination in many areas. This new situation, however, calls for novel diagnostics with improved sensitivity, throughput, and reduced cost for active screening of malaria parasites, as all transfected individuals have to be identified in order to block transmission...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28431618/muscle-strength-and-power-in-persons-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#10
REVIEW
Mlk Jørgensen, U Dalgas, I Wens, L G Hvid
BACKGROUND: Multiple sclerosis (MS) is a chronic disease in the central nervous system which causes a number of physical symptoms including impairments of muscle mechanical function (muscle strength, muscle power and explosive muscle strength (~rate of force development, RFD)). However, a full overview of the existing knowledge regarding muscle mechanical function in persons with MS (PwMS) is still pending. OBJECTIVES: To systematically review 1) the psychometric properties of isokinetic dynamometry testing in PwMS, and 2) studies comparing muscle mechanical function in PwMS to matched healthy controls (HC)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28431503/understanding-the-impact-of-symptoms-on-the-burden-of-copd
#11
REVIEW
Marc Miravitlles, Anna Ribera
Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on individuals with the disease, which can include a range of symptoms (breathlessness, cough, sputum production, wheeze, chest tightness) of varying severities. We present an overview of the biomedical literature describing reported relationships between COPD symptoms and disease burden in terms of quality of life, health status, daily activities, physical activity, sleep, comorbid anxiety, and depression, as well as risk of exacerbations and disease prognosis...
April 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28431482/nanozyme-applications-in-biology-and-medicine-an-overview
#12
Jafar Golchin, Kazem Golchin, Neda Alidadian, Shahrooz Ghaderi, Sajjad Eslamkhah, Masoud Eslamkhah, Abolfazl Akbarzadeh
Nanozymes, in nature, are artificial enzymes. Innovated by Ronald Breslow to mimic enzymes. Nanozymes have widespread applications including targeted cancer therapy, diagnostic medicine and bio-sensing even environmental toxicology. However, these applications are a novel research field in biomedicine, but are growing fast. Enzyme-based applications such as immune-absorbent assay (ELIZA) are expensive because of the complexity of producing enzymes and antibodies. Not only, some nanoparticles can mimic these enzymes such as superoxides, but also they can manipulate biological pathways directly like autophagy...
April 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28430987/rab32-subfamily-small-gtpases-pleiotropic-rabs-in-endosomal-trafficking
#13
Norihiko Ohbayashi, Mitsunori Fukuda, Yasunori Kanaho
Rab small GTPases, well-known regulators of membrane trafficking pathways in eukaryotic cells, comprise approximately 60 different members in mammals. During the past decade, our understanding of the functions of mammalian Rab32 subfamily members (Rab32 and Rab38) have deepened, especially on the biogenesis of lysosome-related organelles, such as melanosomes, and the protection mechanisms against several pathogenic microbial infections. Endosome-mediated membrane trafficking by Rab32 subfamily members plays pivotal roles in these events...
April 14, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28430868/most-visualization-software-for-producing-automated-textbook-style-maps-of-genome-scale-metabolic-networks
#14
James J Kelley, Shay Maor, Min Kyung Kim, Anatoliy Lane, Desmond S Lun
Summary: Visualization of metabolites, reactions and pathways in genome-scale metabolic networks (GEMs) can assist in understanding cellular metabolism. Three attributes are desirable in software used for visualizing GEMs: 1. automation, since GEMs can be quite large; 2. production of understandable maps that provide ease in identification of pathways, reactions, and metabolites; and 3. visualization of the entire network to show how pathways are interconnected. No software currently exists for visualizing GEMs that satisfies all three characteristics, but MOST-Visualization, an extension of the software package MOST (Metabolic Optimization and Simulation Tool), satisfies (1), and by using a pre-drawn overview map of metabolism based on the Roche map satisfies (2) and comes close to satisfying (3)...
April 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28430867/emerging-evidence-for-the-role-of-differential-tumor-microenvironment-in-breast-cancer-racial-disparity-a-closer-look-at-the-surroundings
#15
Sachin Kumar Deshmukh, Sanjeev K Srivastava, Nikhil Tyagi, Aamir Ahmad, Ajay P Singh, Ahmed Al Ghadhban, Donna L Dyess, James E Carter, Kari Dugger, Seema Singh
Although increased awareness leading to early detection and prevention, as well as advancements in treatment strategies, have resulted in superior clinical outcomes, African American women with breast cancer continue to have greater mortality rates, compared to Caucasian American counterparts. Moreover, African American women are more likely to have breast cancer at a younger age and be diagnosed with aggressive tumor sub-types. Such racial disparities can be attributed to socioeconomic differences, but it is increasingly being recognized that these disparities may indeed be due to certain genetic and other non-genetic biological differences...
April 18, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28430854/dynamic-modeling-and-network-approaches-for-omics-time-course-data-overview-of-computational-approaches-and-applications
#16
Yulan Liang, Arpad Kelemen
Inferring networks and dynamics of genes, proteins, cells and other biological entities from high-throughput biological omics data is a central and challenging issue in computational and systems biology. This is essential for understanding the complexity of human health, disease susceptibility and pathogenesis for Predictive, Preventive, Personalized and Participatory (P4) system and precision medicine. The delineation of the possible interactions of all genes/proteins in a genome/proteome is a task for which conventional experimental techniques are ill suited...
April 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28430640/epithelial-mesenchymal-transition-in-prostate-cancer-an-overview
#17
REVIEW
Micaela Montanari, Sabrina Rossetti, Carla Cavaliere, Carmine D'Aniello, Maria Gabriella Malzone, Daniela Vanacore, Rossella Di Franco, Elvira La Mantia, Gelsomina Iovane, Raffaele Piscitelli, Raffaele Muscariello, Massimiliano Berretta, Sisto Perdonà, Paolo Muto, Gerardo Botti, Attilio Antonio Montano Bianchi, Bianca Maria Veneziani, Gaetano Facchini
Prostate cancer is a main urological disease associated with significant morbidity and mortality. Radical prostatectomy and radiotherapy are potentially curative for localized prostate cancer, while androgen deprivation therapy is the initial systemic therapy for metastatic prostate disease. However, despite temporary response, most patients relapse and evolve into castration resistant cancer.Epithelial-mesenchymal transition (EMT) is a complex gradual process that occurs during embryonic development and/or tumor progression...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430591/poly-adenosine-diphosphate-ribose-polymerase-as-therapeutic-target-lessons-learned-from-its-inhibitors
#18
REVIEW
Anna Mária Cseh, Zsolt Fábián, Balázs Sümegi, Luca Scorrano
Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide to a variety of target proteins. Although they have been considered as resident nuclear elements of the DNA repair machinery, recent works revealed a more intricate physiologic role of poly(ADP-ribose) polymerases with numerous extranuclear activities. Indeed, poly(ADP-ribose) polymerases participate in fundamental cellular processes like chromatin remodelling, transcription or regulation of the cell-cycle...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430404/understanding-asexual-identity-as-a-means-to-facilitate-culturally-competent-care-a-systematic-literature-review
#19
REVIEW
Catriona Jones, Mark Hayter, Julie Jomeen
AIMS AND OBJECTIVES: This paper aims to provide a contemporary overview of asexuality and the implications this has for health care practice. BACKGROUND: Individuals belonging to sexual minority groups face many barriers in accessing appropriate health care. The term 'sexual minority group' is usually used to refer to Lesbian Gay Bisexual and Transgender (LGBT) individuals. Anecdotal and research evidence suggests that those who identify as asexual have similar poor experiences...
April 21, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28430111/wavepacket-dynamics-and-the-multi-configurational-time-dependent-hartree-approach
#20
Uwe Manthe
Multi-configurational time-dependent Hartree (MCTDH) based approaches are efficient, accurate, and versatile methods for high-dimensional quantum dynamics simulations. Applications range from detailed investigations of polyatomic reaction processes in the gas phase to high-dimensional simulations studying the dynamics of condensed phase systems described by typical solid state physics model Hamiltonians. The present article presents an overview of the different areas of application and provides on a comprehensive review of the underlying theory...
April 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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