Yannik Laich, Julian Wolf, Rozina Ida Hajdu, Anja Schlecht, Felicitas Bucher, Laurenz Pauleikhoff, Martin Busch, Gottfried Martin, Henrik Faatz, Saskia Killmer, Bertram Bengsch, Andreas Stahl, Albrecht Lommatzsch, Günther Schlunck, Hansjürgen Agostini, Stefaniya Boneva, Clemens Lange
Purpose: Proliferative vitreoretinopathy (PVR) remains an unresolved clinical challenge and can lead to frequent revision surgery and blindness vision loss. The aim of this study was to characterize the microenvironment of epiretinal PVR tissue, in order to shed more light on the complex pathophysiology and to unravel new treatment options. Methods: A total of 44 tissue samples were analyzed in this study, including 19 epiretinal PVRs, 13 epiretinal membranes (ERMs) from patients with macular pucker, as well as 12 internal limiting membranes (ILMs)...
May 2, 2022: Investigative Ophthalmology & Visual Science