Read by QxMD icon Read

Epiretinal fibrosis

Qi Zhang, Yun Qi, Li Chen, Xuan Shi, Yujing Bai, Lvzhen Huang, Wenzhen Yu, Yanrong Jiang, Mingwei Zhao, Xiaoxin Li
PURPOSE: To investigate the progression of epiretinal membranes after intravitreal bevacizumab (IVB) injection therapy in patients with proliferative membranes and evaluate the changes in fibrosis-related cytokines in retinal pigment epithelial cells and glial cells after treatment with bevacizumab. METHODS: Retrospective study of the proliferative membranes in patients with and without IVB therapy. In vitro, the human adult retinal pigment epithelial (ARPE-19) cells and BV2 microglial cell lines were incubated in different bevacizumab concentrations under hypoxic conditions...
October 2016: British Journal of Ophthalmology
Marielle van Deemter, Ruud A Bank, Jelle Vehof, Johanna M M Hooymans, Leonoor I Los
PURPOSE: To explore factors associated with pentosidine accumulation in the human vitreous. METHODS: Vitreous samples were obtained during trans pars plana vitrectomy for macular hole or rhegmatogenous retinal detachment. Patient characteristics included age, gender, and diabetes mellitus. Ocular characteristics included pseudophakia, posterior vitreous detachment, and presence of intraocular fibrosis (epiretinal membrane, proliferative vitreoretinopathy, or both)...
July 26, 2016: Retina
Xiao-Li Chen, Yu-Jing Bai, Qin-Rui Hu, Shan-Shan Li, Lv-Zhen Huang, Xiao-Xin Li
Background. Epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) is vital in proliferative vitreoretinopathy (PVR) development. Apoptosis-stimulating proteins of p53 (ASPP2) have recently been reported to participate in EMT. However, the role of ASPP2 in PVR pathogenesis has not been identified. Methods. Immunohistochemistry was used to investigate the expression of ASPP2 in epiretinal membranes of PVR patients. ARPE-19 cells were transfected with ASPP2-siRNA, followed with measurement of cell cytotoxicity, proliferation, and migration ability...
2016: Mediators of Inflammation
Ning Cheung, Shu-Pei Tan, Shu Yen Lee, Gemmy Chui Ming Cheung, Gavin Tan, Neelam Kumar, Ching-Yu Cheng, Tien Yin Wong
AIM: To examine prevalence and risk factors of epiretinal membrane (ERM) in a large, contemporary, multiethnic Asian population. METHODS: Combined analysis of three population-based studies of eye diseases, with a total of 9799 Chinese, Malays and Indians residing in the general communities of Singapore. A comprehensive ophthalmic examination, interviews and laboratory blood tests were performed to assess potential risk factors. Digital retinal photographs were used to assess ERM according to a standardised protocol...
June 24, 2016: British Journal of Ophthalmology
Wentao Luo, Liumei Hu, Weiye Li, Guotong Xu, Linxinyu Xu, Conghui Zhang, Fang Wang
BACKGROUND: In proliferative diabetic retinopathy (PDR), Müller glial cells (MGCs) acquire migratory ability and exhibit a fibroblast-like phenotype. These activated MGCs contribute to the formation of epiretinal membrane, which will stretch the retina, and cause retinal detachment and vitreous hemorrhage. Erythropoietin (Epo) is now found effective in ameliorating renal fibrosis by inhibiting epithelial-to-mesenchymal transition of tubular epithelial cells. This study is undertaken to determine whether Epo has an effect in inhibiting MGCs activation to attenuate epiretinal membrane formation in PDR...
May 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Eri Takahashi, Ayako Fukushima, Akira Haga, Yasuya Inomata, Yasuhiro Ito, Mikiko Fukushima, Hidenobu Tanihara
In rhegmatogenous retinal detachment (RRD), scattered RPE cells from the basement membrane into the vitreous cavity undergo an epithelial mesenchymal transition (EMT) and form the intraocular fibrous membrane in response to vitreous fluid. We investigated whether exposure to vitreous samples was associated with EMT-associated signals and mesenchymal characters. Human vitreous samples were collected from patients with RRD, epiretinal membrane (ERM), or macular hole (MH). We evaluated the effects of vitreous on ARPE-19 cells in suspension cultures using poly 2-hydroxyethyl methacrylate-coated dishes and three-dimensional (3D) Matrigel cultures...
February 12, 2016: Biochemical and Biophysical Research Communications
C Fernández-Martínez, J J Martínez-Toldos, F Hernández-Artola
CASE REPORT: A 34 year-old man presented with progressive visual loss in his right eye. Ocular fundus showed a vasoproliferative tumor in the peripheral retina with an associated epiretinal macular membrane. Angiography showed a rapid filling of tumor vessels. The treatment consisted of laser photocoagulation and a single injection of intravitreal ranibizumab. After 8 weeks, there was a residual area of fibrosis, the posterior hyaloid was detached, and the epiretinal membrane disappeared...
December 2015: Archivos de la Sociedad Española de Oftalmología
Tsunehiko Ikeda, Kimitoshi Nakamura, Hidehiro Oku, Seita Morishita, Masanori Fukumoto, Hiroyuki Suzuki, Teruyo Kida, Taeko Horie, Tetsuya Sugiyama, Shinji Takai
PURPOSE: To investigate the pathogenesis of idiopathic epiretinal membrane (ERM) from a biochemical perspective, the relationships between ERM and tryptase activity, a serine protease, and the levels of anti-type II collagen (anti-IIC) antibodies in the serum. PATIENTS AND METHODS: Vitreous samples for measurement of tryptase activity were obtained from 54 eyes of 54 patients who underwent a vitrectomy for vitreoretinal disease, ie, 14 eyes of 14 patients with idiopathic macular hole, 14 eyes of 14 patients with proliferative diabetic retinopathy (PDR), 13 eyes of 13 patients with ERM, and 13 eyes of 13 patients with rhegmatogenous retinal detachment (RRD)...
2015: Clinical Ophthalmology
V V Egorov, N V Savchenko, E L Sorokin, O V Danilov
AIM: To study the frequency of patients with macular pathology being wrongly diagnosed with cataract and possible reasons for this to occur. MATERIAL AND METHODS: A total of 1390 patients (1390 eyes), in whom cataract turned out to be not the main cause of visual impairment, were recruited as research subjects. To reveal the reasons for misdiagnosis, we resorted to methods of ophthalmic examination that are available at ambulatory care facilities, i.e. visual acuity measurement, slit lamp biomicroscopy of the anterior and posterior eye segments, direct and indirect ophthalmoscopy...
March 2015: Vestnik Oftalmologii
Hehua Ye, Qi Zhang, Xiaohong Liu, Xuan Cai, Wenjing Yu, Siyi Yu, Tianyu Wang, Wuyi Lu, Xiang Li, Yiqian Hu, Bo Yang, Peiquan Zhao
AIMS: To describe the prevalence and associations of epiretinal membrane (ERM) in an elderly urban Chinese population in China. METHODS: A population-based cross-sectional study was conducted using a cluster random sample of residents aged 50 years or older living in the Jiangning Road Sub-district, Shanghai, China. All participants underwent a standardised interview and comprehensive eye examinations, including digital retinal photography and spectral domain optical coherence tomography (SD-OCT) examinations of both eyes between November 2012 and February 2013...
December 2015: British Journal of Ophthalmology
Sarah B Wang, Paul Mitchell, Adam J H Plant, Kevin Phan, Gerald Liew, Joseph Chiha, Aravinda Thiagalingam, George Burlutsky, Bamini Gopinath
AIMS: To describe the prevalence of idiopathic and secondary epiretinal membranes (ERM) in a clinical cohort (Australian Heart Eye Study, AHES) and compare to the Blue Mountains Eye Study, and to determine whether associations exist between idiopathic ERM and the extent and severity of coronary artery disease (CAD). METHODS: The AHES is an observational study that surveyed 1680 participants who presented to a tertiary referral hospital for the evaluation of potential CAD by coronary angiography...
December 2015: British Journal of Ophthalmology
Ahmed M Abu El-Asrar, Mohd Imtiaz Nawaz, Gert De Hertogh, Kaiser Alam, Mohammad Mairaj Siddiquei, Kathleen Van den Eynde, Ahmed Mousa, Ghulam Mohammad, Karel Geboes, Ghislain Opdenakker
PURPOSE: The calcium-binding protein S100A4 is implicated in cancer cell invasion and metastasis, the stimulation of angiogenesis, the progression of fibrosis, and inflammatory disorders. We investigated the expression of S100A4 and correlated it with clinical disease activity as well as with the levels of osteopontin (OPN), soluble syndecan-1, and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy (PDR). To reinforce the findings at the functional level, we examined the expressions of S100A4 and OPN in the retinas of diabetic rats and in human retinal microvascular endothelial cells (HRMECs) following exposure to VEGF and the proinflammatory cytokine tumor necrosis factor-α (TNF-α)...
2014: Molecular Vision
Rim Kahloun, Nesrine Abroug, Wafa Ammari, Anis Mahmoud, Bechir Jelliti, Salim Ben Yahia, Moncef Khairallah
We report a case of a 14-year-old otherwise healthy patient who developed acute retinal periphlebitis mimicking frosted branch angiitis inferotemporally and associated exudative retinal detachment in the left eye following blunt trauma. Fluorescein angiography revealed delayed filling of inferotemporal branch retinal vein and late leakage of sheathed retinal venules, and late pooling in the area of exudative retinal detachment. Indocyanine green angiography showed a crescent-shaped hypofluorescent streak concentric to the optic disk inferiorly highly suggestive of choroidal rupture...
October 2014: International Ophthalmology
Sophie J Bakri, Saba T Alniemi
Steroids are commonly used as adjunct therapy in the management of proliferative vitreoretinopathy. The authors report a case of proliferative vitreoretinopathy treated with an intravitreal dexamethasone implant following vitrectomy in a silicone oil-filled eye. Epiretinal fibrosis developed around the implant at 6 weeks postoperatively, resulting in a recurrent retinal detachment. This was repaired by vitrectomy, removal of the implant, and peeling of epiretinal proliferation.
May 2014: Ophthalmic Surgery, Lasers & Imaging Retina
(no author information available yet)
The study enrolled 177 patients that had been admitted to the Research Institute of Eye Diseases of the Russian Academy of Medical Sciences for diagnostics and treatment - 134 patients with idiopathic macular hole and 43 patients with epiretinal fibrosis. All vitreomacular surgeries were performed between 2005 and 2011. Visual field defects were seen in all groups and were classified as either peripheral or paracentral, or concentric. The groups differed by the rate and the localization of the visual field defects...
September 2013: Vestnik Oftalmologii
Ahmed M Abu El-Asrar, Ghulam Mohammad, Gert De Hertogh, Mohd Imtiaz Nawaz, Kathleen Van Den Eynde, Mohammad Mairaj Siddiquei, Sofie Struyf, Ghislain Opdenakker, Karel Geboes
Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and their receptors TrkA, TrkB, and TrkC in proliferative diabetic retinopathy (PDR). As a comparison, we examined the expression of NTs and their receptors in the retinas of diabetic rats. Vitreous samples from 16 PDR and 15 nondiabetic patients were studied by Western blot analysis and enzyme-linked immunosorbent assay (ELISA)...
2013: PloS One
S V Sdobnikova, A L Sidamonidze, I V Kozlova, N A Troitskaia
The goal of the study was to determine vitrectomy effect on ocular hydrodynamics. Patients were divided into 2 groups: patients with diabetes mellitus (DM) were enrolled in the 1st group, indications for vitrectomy were vitreous hemorrhage or diabetic macula edema. The 2nd group included patients without DM, indications for vitrectomy were macula hole, epiretinal fibrosis. Electronic tonography was used to measure the main ocular hydrodynamic parameters before and 2-12 months after the surgery. Though intraocular pressure (IOP) increased after vitrectomy in all patients, the true IOP was normal in the majority of them (60%) and did not require medical correction...
January 2013: Vestnik Oftalmologii
S V Sdobnikova, I V Kozlova, D S Alekseenko
As a result of the study analysis of potential causes of visual field defects (VFD) after vitreomacular surgery is performed. 110 cases are enrolled in the study: 81 patient with macular hole and 29 patients with epiretinal fibrosis. Correspondence of VFD to position of irrigation port including unusual inferior-nasal position was revealed as well as VFD absence in epiretinal fibrosis operated without air pump. VFD did not appear after lowering of air pump pressure by 15-20 mmHg. The cause of VFD after vitreomacular surgery is a mechanical damage of internal retinal surface by directed air/gas jet after total fluid exchange with too high pressure in an air pump...
January 2013: Vestnik Oftalmologii
Calvin Sze-Un Fong, Paul Mitchell, Elena Rochtchina, Thomas Hong, Tania de Loryn, Jie Jin Wang
PURPOSE: To assess eye-specific epiretinal membrane (ERM) incidence 3 years after phacoemulsification surgery, and ERM detection bias attributable to cataract. DESIGN: Cohort study. METHODS: We recruited 1932 cataract surgical patients aged ≥64 years at Westmead Hospital (2004-2007). The surgical eye of each patient was assessed for presence of cellophane reflex or preretinal fibrosis at preoperative and 1-month-postoperative visits, and annually thereafter, using retinal image grading...
August 2013: American Journal of Ophthalmology
Khin Z Aung, Galina Makeyeva, Madeleine K Adams, Elaine W-T Chong, Lucy Busija, Graham G Giles, Dallas R English, John Hopper, Paul N Baird, Robyn H Guymer, Liubov D Robman
PURPOSE: To determine the prevalence of epiretinal membranes (ERMs) in Melbourne, Australia and its risk factors in this population. METHODS: The Melbourne Collaborative Cohort Study is a prospective study investigating the role of diet and life style in the causation of common chronic diseases. Eighty-six percent of participants were of Northern European origin born in Australia or United Kingdom and 14% were migrants from Greece or Italy (Southern European origin)...
May 2013: Retina
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"