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https://www.readbyqxmd.com/read/28345601/towards-reproducible-mrm-based-biomarker-discovery-using-dried-blood-spots
#1
Sureyya Ozcan, Jason D Cooper, Santiago G Lago, Diarmuid Kenny, Nitin Rustogi, Pawel Stocki, Sabine Bahn
There is an increasing interest in the use of dried blood spot (DBS) sampling and multiple reaction monitoring in proteomics. Although several groups have explored the utility of DBS by focusing on protein detection, the reproducibility of the approach and whether it can be used for biomarker discovery in high throughput studies is yet to be determined. We assessed the reproducibility of multiplexed targeted protein measurements in DBS compared to serum. Eighty-two medium to high abundance proteins were monitored in a number of technical and biological replicates...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344947/factors-associated-with-odontogenic-bacteraemia-in-orthodontic-patients
#2
O D Umeh, O O Sanu, I L Utomi, F O Nwaokorie
BACKGROUND: Various researches have investigated factors associated with the prevalence and intensity of bacteraemia following oral procedures including orthodontic procedures. AIM: The aim of this study was to determine the effect of age, gender, plaque and gingival indices on the occurrence of odontogenic bacteraemia following orthodontic treatment procedures. SETTING: Orthodontic Clinic, Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
April 2016: Journal of the West African College of Surgeons
https://www.readbyqxmd.com/read/28338097/the-cellular-protein-hnrnp-a2-b1-enhances-hiv-1-transcription-by-unfolding-ltr-promoter-g-quadruplexes
#3
Matteo Scalabrin, Ilaria Frasson, Emanuela Ruggiero, Rosalba Perrone, Elena Tosoni, Sara Lago, Martina Tassinari, Giorgio Palù, Sara N Richter
G-quadruplexes are four-stranded conformations of nucleic acids that act as cellular epigenetic regulators. A dynamic G-quadruplex forming region in the HIV-1 LTR promoter represses HIV-1 transcription when in the folded conformation. This activity is enhanced by nucleolin, which induces and stabilizes the HIV-1 LTR G-quadruplexes. In this work by a combined pull-down/mass spectrometry approach, we consistently found hnRNP A2/B1 as an additional LTR-G-quadruplex interacting protein. Surface plasmon resonance confirmed G-quadruplex specificity over linear sequences and fluorescence resonance energy transfer analysis indicated that hnRNP A2/B1 is able to efficiently unfold the LTR G-quadruplexes...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337490/effect-of-trimethoprim-sulfamethoxazole-prophylaxis-on-feacal-carriage-rates-of-resistant-isolates-of-escherichia-coli-in-hiv-infected-adult-patients-in-lagos
#4
C C Egwuatu, F T Ogunsola, A A Iwuafor, C N Akujobi, T O Egwuatu, A U Nnachi, O O Oduyebo
BACKGROUND: The daily use of Trimethoprim-Sulfamethoxazole (TMP-SMX) prophylaxis reduces morbidity and mortality among patients infected with human immunodeficiency virus (HIV) but its impact on increasing antimicrobial resistance rates has been of public health concern, globally. This study investigated the effect of daily TMP-SMX prophylaxis on feacal carriage rates of resistant isolates of Escherichia coli in HIV-infected adult patients in Lagos. METHODS: A total of 550 HIV-infected patients with CD4-cell counts of less than 350 cells/mm(3) who were eligible for TMP-SMX prophylaxis and attending Lagos University Teaching Hospital, Lagos, Nigeria, were recruited for this study...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28336188/identification-characterization-and-modulation-of-ferritin-h-in-the-sub-antarctic-notothenioid-eleginops-maclovinus-challenged-with-piscirickettsia-salmonis
#5
D Martínez, R Oyarzún, C Vargas-Lagos, J P Pontigo, M Soto-Dávila, J Saravia, A Romero, J J Núñez, A J Yáñez, L Vargas-Chacoff
Ferritin is a major iron storage protein essential not only in the infectious process, but also in any circumstance generating oxidative stress. In this study, the cDNA coding sequence of ferritin-H was obtained from the sub-Antarctic Notothenioid fish Eleginops maclovinus through transcriptomic analysis of the head kidney. This sequence contained a 534 bp open reading frame that coded for a 177 amino acid protein with a molecular weight of 20,786.2 Da and a theoretical pI of 5.56. The protein displayed a region of iron putative response elements in the 5'UTR, two putative ferritin iron-binding region signatures, and seven characteristic amino acids with ferroxidase functions...
March 21, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28333998/calibrating-coseismic-coastal-land-level-changes-during-the-2014-iquique-mw-8-2-earthquake-northern-chile-with-leveling-gps-and-intertidal-biota
#6
Eduardo Jaramillo, Daniel Melnick, Juan Carlos Baez, Henry Montecino, Nelson A Lagos, Emilio Acuña, Mario Manzano, Patricio A Camus
The April 1st 2014 Iquique earthquake (MW 8.1) occurred along the northern Chile margin where the Nazca plate is subducted below the South American continent. The last great megathrust earthquake here, in 1877 of Mw ~8.8 opened a seismic gap, which was only partly closed by the 2014 earthquake. Prior to the earthquake in 2013, and shortly after it we compared data from leveled benchmarks, deployed campaign GPS instruments, continuous GPS stations and estimated sea levels using the upper vertical level of rocky shore benthic organisms including algae, barnacles, and mussels...
2017: PloS One
https://www.readbyqxmd.com/read/28332537/mapping-vibrational-surface-and-bulk-modes-in-a-single-nanocube
#7
Maureen J Lagos, Andreas Trügler, Ulrich Hohenester, Philip E Batson
Imaging of vibrational excitations in and near nanostructures is essential for developing low-loss infrared nanophotonics, controlling heat transport in thermal nanodevices, inventing new thermoelectric materials and understanding nanoscale energy transport. Spatially resolved electron energy loss spectroscopy has previously been used to image plasmonic behaviour in nanostructures in an electron microscope, but hitherto it has not been possible to map vibrational modes directly in a single nanostructure, limiting our understanding of phonon coupling with photons and plasmons...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28331079/characterization-and-vaccine-potential-of-membrane-vesicles-produced-by-francisella-noatunensis-sup-orientalis-in-an-adult-zebrafish-model
#8
Leidy Lagos, Julia I Tandberg, Urska Repnik, Preben Boysen, Erik Ropstad, Deepa Varkey, Ian T Paulsen, Hanne C Winther-Larsen
Vaccine development against extracellular bacteria has been important for the sustainability of the aquaculture industry. In contrast, infections with intracellular pathogens remain largely an unresolved problem. Francisella noatunensis subspecies orientalis (Fno) are Gram-negative, facultative intracellular bacteria that cause the disease francisellosis in fish. Francisellosis is commonly characterized as a chronic granulomatous disease with high morbidity and can result in high mortality depending on the host...
March 22, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28320907/a-velocity-map-imaging-study-of-methyl-non-resonant-multiphoton-ionization-from-the-photodissociation-of-ch3i-in-the-a-band
#9
Sonia Marggi Poullain, David V Chicharro, Luis Rubio-Lago, Alberto García-Vela, Luis Bañares
Chemical reaction dynamics and, particularly, photodissociation in the gas phase are generally studied using pump-probe schemes where a first laser pulse induces the process under study and a second one detects the produced fragments. Providing an efficient detection of ro-vibrationally state-selected photofragments, the resonance enhanced multiphoton ionization (REMPI) technique is, without question, the most popular approach used for the probe step, while non-resonant multiphoton ionization (NRMPI) detection of the products is scarce...
April 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28316638/sentiment-analysis-on-tweets-about-diabetes-an-aspect-level-approach
#10
María Del Pilar Salas-Zárate, José Medina-Moreira, Katty Lagos-Ortiz, Harry Luna-Aveiga, Miguel Ángel Rodríguez-García, Rafael Valencia-García
In recent years, some methods of sentiment analysis have been developed for the health domain; however, the diabetes domain has not been explored yet. In addition, there is a lack of approaches that analyze the positive or negative orientation of each aspect contained in a document (a review, a piece of news, and a tweet, among others). Based on this understanding, we propose an aspect-level sentiment analysis method based on ontologies in the diabetes domain. The sentiment of the aspects is calculated by considering the words around the aspect which are obtained through N-gram methods (N-gram after, N-gram before, and N-gram around)...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28300893/steatocystoma-multiplex-suppurativa-case-report-of-a-rare-condition
#11
Cândida Naira Lima E Lima Santana, Daniele do Nascimento Pereira, Alice Paixão Lisboa, Juliana Martins Leal, Daniel Lago Obadia, Roberto Souto da Silva
Steatocystoma multiplex is a rare genetic disorder characterized by the presence of hamartomatous malformations at the junction of the pilosebaceous duct. It consists of encapsulated cystic lesions in the dermis, with adjacent sebaceous gland. When associated with inflammation, resembling hidradenitis, it is called steatocystoma multiplex suppurativa, a condition rarely reported. This is the first case of steatocystoma multiplex suppurativa reported in the Brazilian literature. Female patient, 23 years old, with papular and nodular cystic lesions that started in the armpits and groin, later spreading to the trunk, lower limbs, anticubital fossa, face and scalp...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28299257/cleft-lip-and-palate-parental-experiences-of-stigma-discrimination-and-social-structural-inequalities
#12
Wasiu Lanre Adeyemo, Olutayo James, Azeez Butali
BACKGROUND: Cleft lip and palate (CLP) are the most common craniofacial birth impairment and one of the most common congenital impairments in humans. Anecdotal evidence suggests that stigmatization, discrimination, and sociocultural inequalities are common "phenomenon" experienced by families of children with CLP in Nigeria. This study aimed to explore the stigmatization, discrimination, and sociocultural inequalities experiences of families with children born with CLP. MATERIALS AND METHODS: The study was carried out at the surgical outpatient cleft clinic of the Lagos University Teaching Hospital, Lagos, Nigeria...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28299159/autism-spectrum-disorder-in-a-community-based-sample-with-neurodevelopmental-problems-in-lagos-nigeria
#13
Yewande O Oshodi, Andrew T Olagunju, Motunrayo A Oyelohunnu, Elizabeth A Campbell, Charles S Umeh, Olatunji F Aina, Wellington Oyibo, Folusho E A Lesi, Joseph D Adeyemi
Autism Spectrum Disorder (ASD) is a globally prevalent neurodevelopmental disorder for which early diagnosis and intervention is the mainstay of management. In the African continent, limited data is available regarding the non-clinic based samples. Lack of information available to caregivers and inadequate skilled manpower often limit early detection and access to the few available though under resourced services in the community. Community based screening can be an important drive to create awareness and improve information dissemination regarding services available for those living with this disorder...
December 31, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28295585/systematic-review-of-non-pharmacological-analgesic-interventions-for-common-needle-related-procedure-in-newborn-infants-and-development-of-evidence-based-clinical-guidelines
#14
REVIEW
P Lago, E Garetti, C V Bellieni, D Merazzi, P Savant Levet, G Ancora, A Pirelli
The aim of this literature review was to develop clinical guidelines for the prevention and control of needle-related pain in newborn infants. The guidelines were developed by the Italian Society of Neonatology, using the Grading of Recommendations, Assessment, Development and Evaluation approach, based on the assessment of 232 papers published between 1986 and 2015. The quality of the evidence was high or moderate for some behavioural and non-pharmacological interventions. CONCLUSION: There was sufficient evidence to strongly support the use of non-pharmacological interventions for common needle-related procedures in newborn infants...
March 12, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28293783/translation-and-validation-of-the-rhinosinusitis-disability-index-for-use-in-nigeria
#15
C N Asoegwu, C C Nwawolo, N U Okubadejo
The Rhinosinusitis Disability Index (RSDI) is a validated and reliable measure of severity of chronic rhinosinusitis. The objective of this study was to translate and validate the instrument for use in Nigeria. This is a methodological study. 71 patients with chronic rhinosinusitis attending two Otolaryngology clinics in Lagos, Nigeria. Using standardized methods and trained translators, the RSDI was translated to vernacular (Yoruba language) and back-translated to culturally appropriate English. Data analysis comprised of assessment of the item quality, content validity and internal consistency of the back-translated Rhinosinusitis Disability Index (bRSDI), and correlation to the original RSDI...
March 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28285904/mex3a-marks-a-slowly-dividing-subpopulation-of-lgr5-intestinal-stem-cells
#16
Francisco M Barriga, Elisa Montagni, Miyeko Mana, Maria Mendez-Lago, Xavier Hernando-Momblona, Marta Sevillano, Amy Guillaumet-Adkins, Gustavo Rodriguez-Esteban, Simon J A Buczacki, Marta Gut, Holger Heyn, Douglas J Winton, Omer H Yilmaz, Camille Stephan-Otto Attolini, Ivo Gut, Eduard Batlle
Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell (ISC) populations have been described, the identity and features of such a population remain controversial. Here we report unanticipated heterogeneity within the Lgr5+ ISC pool. We found that expression of the RNA-binding protein Mex3a labels a slowly cycling subpopulation of Lgr5+ ISCs that contribute to all intestinal lineages with distinct kinetics. Single-cell transcriptome profiling revealed that Lgr5+ cells adopt two discrete states, one of which is defined by a Mex3a expression program and relatively low levels of proliferation genes...
March 8, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28285853/tracking-climate-change-in-oligotrophic-mountain-lakes-recent-hydrology-and-productivity-synergies-in-lago-de-sanabria-nw-iberian-peninsula
#17
Margarita Jambrina-Enríquez, Clemente Recio, José Carlos Vega, Blas Valero-Garcés
Mountain lakes are particularly sensitive to global change as their oligotrophic conditions may be rapidly altered after reaching an ecological threshold, due to increasing human impact and climate change. Sanabria Lake, the largest mountain lake in the Iberian Peninsula and with a recent history of increased human impact in its watershed, provides an opportunity to investigate recent trends in an oligotrophic, hydrologically-open mountain lake, and their relationship with climate, hydrological variability and human pressure...
March 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28284705/characterization-of-misfit-dislocations-in-si-quantum-well-structures-enabled-by-stem-based-aberration-correction
#18
Philip E Batson, Maureen J Lagos
The success of aberration correction techniques at the end of the 20th century came at a time of increasing need for atomic resolution imaging to better understand known structural defects that influence semiconductor device operation, and to advance the search for new structures and behavior that will form the basis for devices in the future. With this in mind, it is a pleasure to recognize the contributions of Ondrej Krivanek to the success of aberration correction techniques, and his extension of aberration techniques to EELS equipment that further promises to unite structural studies with characterization of behavior from meV to keV energies in the STEM...
March 2, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28280508/is-it-necessary-to-prepare-the-enamel-before-dental-bleaching
#19
Andréa Dias Neves Lago, Patrícia Moreira de Freitas, Erika Michele Dos Santos Araújo, Adriana Bona Matos, Narciso Garone-Netto
The aim of this in vitro study was to assess the influence of distinct surface treatments on the microhardness and color of enamel that will be bleached. Surface treatments are tested, accordingly: G1, no treatment; G2, 2% sodium fluoride; G3, casein phosphopeptide paste; G4, 2% fluoride+Nd:YAG laser. Forty blocks from bovine teeth composed the sample that were tested in Knoop microhardness (n = 10) and in color change (n = 10). After 24 h, bleaching with 35% hydrogen peroxide was performed for 45 min. Microhardness and color changes (using parameters ΔE, ΔL, Δa, and Δb) were assessed before and after bleaching...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28279576/ultra-low-background-and-environmental-measurements-at-laboratorio-subterr%C3%A3-neo-de-canfranc-lsc
#20
I Bandac, S Borjabad, A Ianni, R Nuñez-Lagos, C Pérez, S Rodríguez, J A Villar
To support the construction of experiments at the Laboratorio Subterráneo de Canfranc (LSC) in Spain, an Ultra-Low Background Service (ULBS) and a Copper Electroforming Service (CES) were created. The measurement technique employed at the ULBS is gamma spectroscopy with high purity germanium (HPGe) detectors. A new anti-radon system is being implemented. The main goal of CES is to obtain high-purity copper pieces. A new electroforming set-up inside LSC underground clean room is planned. Radon and environmental measurements at the LSC are presented...
March 4, 2017: Applied Radiation and Isotopes
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