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https://www.readbyqxmd.com/read/28078747/granulocyte-monocyte-apheresis-as-an-adjuvant-therapy-to-anti-tumor-necrosis-factor-drugs-for-ulcerative-colitis
#1
Iago Rodríguez-Lago, Laura Gómez-Irwin, Encarnación Fernández, Rebeca Higuera, José Luis Cabriada
Biologic anti-tumor necrosis factor (TNF) drugs have demonstrated their efficacy for the treatment of ulcerative colitis. Nevertheless, some patients will not respond to this therapy or will develop loss of response. Leukapheresis is the main non-pharmacological therapy for some immune-mediated diseases. The aim of our study was to describe our experience with this therapy in ulcerative colitis patients after loss of response to anti-TNF treatment. Leukapheresis was indicated in four patients with left-sided or extensive colitis because of partial response to biological therapy or secondary loss of response to it...
January 11, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28076455/decreased-platelet-responsiveness-to-clopidogrel-correlates-with-cyp2c19-and-pon1-polymorphisms-in-atherosclerotic-patients
#2
J F M Marchini, M R Pinto, G C Novaes, A V Badran, R B Pavão, G L Figueiredo, I M Lago, M O Lima-Filho, D C Lemos, M Tonani, C M Antloga, L Oliveira, J C Lorenzi, J A Marin-Neto
Clopidogrel and aspirin are the most commonly used medications worldwide for dual antiplatelet therapy after percutaneous coronary intervention. However, clopidogrel hyporesponsiveness related to gene polymorphisms is a concern. Populations with higher degrees of genetic admixture may have increased prevalence of clopidogrel hyporesponsiveness. To assess this, we genotyped CYP2C19, ABCB1, and PON1 in 187 patients who underwent percutaneous coronary intervention. Race was self-defined by patients. We also performed light transmission aggregometry with adenosine diphosphate (ADP) and arachidonic acid during dual antiplatelet therapy...
January 9, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28073537/role-of-resting-cysts-in-chilean-alexandrium-catenella-dinoflagellate-blooms-revisited
#3
Jorge I Mardones, Chris Bolch, Leonardo Guzmán, Javier Paredes, Daniel Varela, Gustaaf M Hallegraeff
The detection of sparse Alexandrium catenella-resting cysts in sediments of southern Chilean fjords has cast doubts on their importance in the recurrence of massive toxic dinoflagellate blooms in the region. The role of resting cysts and the existence of different regional Chilean populations was studied by culturing and genetic approaches to define: (1) cyst production; (2) dormancy period; (3) excystment success; (4) offspring viability and (5) strain mating compatibility. This study newly revealed a short cyst dormancy (minimum 69 days), the role of key abiotic factors (in decreasing order salinity, irradiance, temperature and nutrients) controlling cyst germination (max...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073104/use-of-transcutaneous-bilirubin-to-determine-the-need-for-phototherapy-in-resource-limited-settings
#4
Bolajoko O Olusanya, Abieyuwa A Emokpae
BACKGROUND: Routine and timely determination of total serum bilirubin (TSB) remains a challenge in many resource-limited countries with substantial burden of severe neonatal hyperbilirubinemia. Limited evidence exists on the potential usefulness of transcutaneous bilirubin (TcB) to identify infants who may require phototherapy based on possible treatment criteria in such settings. OBJECTIVE: To compare the number of infants requiring phototherapy across different TSB criteria and determine the predictive performance of TcB under each criterion...
January 11, 2017: Neonatology
https://www.readbyqxmd.com/read/28071146/cardiac-rehabilitation-programme-after-transcatheter-aortic-valve-implantation-versus-surgical-aortic-valve-replacement-systematic-review-and-meta-analysis
#5
Gustavo S Ribeiro, Rosangela D Melo, Luís F Deresz, Pedro Dal Lago, Mauro Rn Pontes, Marlus Karsten
Background Aortic stenosis is a valvular heart disease characterised by fixed obstruction of the left ventricular outflow. It can be managed by surgical aortic valve replacement (sAVR) or transcatheter aortic valve implantation (TAVI). This review aimed to describe the evidence supporting a cardiac rehabilitation programme on functional capacity and quality of life in aortic stenosis patients after sAVR or TAVI. Methods The search was conducted on multiple databases from January to March 2016. All studies were eligible that evaluated the effects of a post-interventional cardiac rehabilitation programme in aortic stenosis patients...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28070317/prevention-of-microbial-hazard-on-fresh-cut-lettuce-through%C3%A2-adoption-of-food-safety-and-hygienic-practices-by%C3%A2-lettuce-farmers
#6
Lateefah A Oyinlola, Adewale O Obadina, Adebukunola M Omemu, Olusola B Oyewole
Lettuce is consumed raw in salads and is susceptible to microbial contamination through environment, agricultural practices, and its morphology, thus, a potential vehicle for food-borne illness. This study investigated the effect of adoption of food safety and hygienic practices by lettuce farmers on the microbial safety of field sourced lettuce in Lagos State, Nigeria. Ten structured questionnaires were administered randomly to 10 lettuce farmers to assess food safety and hygienic practices (FSH). Two farmers who practice FSH and two farmers who do not practice NFSH were finally used for this study...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28069688/up-regulation-of-cb2-receptors-in-reactive-astrocytes-in-canine-degenerative-myelopathy-a-disease-model-of-amyotrophic-lateral-sclerosis
#7
María Fernández-Trapero, Francisco Espejo-Porras, Carmen Rodríguez-Cueto, Joan R Coates, Carmen Pérez-Díaz, Eva de Lago, Javier Fernández-Ruiz
Targeting the CB2 receptor afforded neuroprotection in SOD1(G93A) mutant mice, a model of amyotrophic lateral sclerosis (ALS). The neuroprotective effects of CB2 receptors were facilitated by their up-regulation in the spinal cord in SOD1(G93A) mutant mice. Herein, we have investigated whether a similar CB2 receptor up-regulation, as well as parallel changes in other endocannabinoid elements, are evident in the spinal cord of dogs with degenerative myelopathy (DM), caused from mutations in the superoxide dismutase 1 gene (SOD1)...
January 9, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28068123/coreference-and-antecedent-representation-across-languages
#8
Sol Lago, Shayne Sloggett, Zoe Schlueter, Wing Yee Chow, Alexander Williams, Ellen Lau, Colin Phillips
Previous studies have shown that speakers of languages such as German, Spanish, and French reactivate the syntactic gender of the antecedent of a pronoun to license gender agreement. As syntactic gender is assumed to be stored in the lexicon, this has motivated the claim that pronouns in these languages reactivate the lexical entry of their antecedent noun. In contrast, in languages without syntactic gender such as English, lexical retrieval might be unnecessary. We used eye-tracking while reading to examine whether antecedent retrieval involves rapid semantic and phonological reactivation...
January 9, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28066863/assessing-equity-in-the-provision-of-primary-healthcare-centers-in-buenos-aires-province-argentina-a-stochastic-frontier-analysis
#9
Florencia Arnaudo, Fernando Lago, Valentina Viego
BACKGROUND: Unequal access to healthcare between individuals or populations does not imply the existence of inequities as it must be controlled for differences in need. This is usually done either via direct or indirect standardization methods. OBJECTIVE: We study the degree of equity in the availability of public primary healthcare centers between the 134 municipalities of the Buenos Aires province (Argentina) with a novel application of an existing statistical tool...
January 9, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28064117/differential-proteomic-and-oxidative-profiles-unveil-dysfunctional-protein-import-to-adipocyte-mitochondria-in-obesity-associated-aging-and-diabetes
#10
María Gómez-Serrano, Emilio Camafeita, Juan A López, Miguel A Rubio, Irene Bretón, Inés García-Consuegra, Eva García-Santos, Jesús Lago, Andrés Sánchez-Pernaute, Antonio Torres, Jesús Vázquez, Belén Peral
Human age-related diseases, including obesity and type 2 diabetes (T2DM), have long been associated to mitochondrial dysfunction; however, the role for adipose tissue mitochondria in these conditions remains unknown. We have tackled the impact of aging and T2DM on adipocyte mitochondria from obese patients by quantitating not only the corresponding abundance changes of proteins, but also the redox alterations undergone by Cys residues thereof. For that, we have resorted to a high-throughput proteomic approach based on isobaric labeling, liquid chromatography and mass spectrometry...
December 18, 2016: Redox Biology
https://www.readbyqxmd.com/read/28060860/prevalence-and-incidence-of-hcv-infection-among-prisoners-in-central-brazil
#11
Marco Antonio Moreira Puga, Larissa Melo Bandeira, Mauricio Antonio Pompilio, Julio Croda, Grazielli Rocha de Rezende, Luiz Fernando Paiva Dorisbor, Tayana Serpa Ortiz Tanaka, Gabriela Alves Cesar, Sheila Araújo Teles, Simone Simionatto, Alisson Richard Teixeira Novais, Bruna Nepomuceno, Lisie Souza Castro, Barbara Vieira do Lago, Ana Rita Coimbra Motta-Castro
The aim of this multicenter, cross sectional study was to assess the prevalence, incidence and associated risk factors among incarcerated populations from twelve Brazilian prisons. The total of 3,368 individuals from twelve prisons was randomly recruited between March 2013 and March 2014. Participants were interviewed, and provided blood samples which were tested for antibodies to Hepatitis C (HCV ab). One year after the first investigation, a cohort study was conducted with 1,656 inmates who participated the cross sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28057514/systemic-effects-of-subtilase-cytotoxin-produced-by-escherichia-coli-o113-h21
#12
E Abril Seyahian, Gisela Oltra, Federico Ochoa, Santiago Melendi, Ricardo Hermes, James C Paton, Adrienne W Paton, Nestor Lago, Mauricio Castro Parodi, Alicia Damiano, Cristina Ibarra, Elsa Zotta
: Subtilase cytotoxin (SubAB) is a member of the AB5 cytotoxin family and is produced by certain strains of Shiga toxigenic Escherichia coli. The toxin is known to be lethal to mice, but the pathological mechanisms that contribute to Uremic Hemolytic Syndrome (HUS) are poorly understood. In this study we show that intraperitoneal injection of a sublethal dose of SubAB in rats triggers a systemic response, with ascitic fluid accumulation, heart hypertrophy and damage to the liver, colon and kidney...
January 2, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28056569/maternal-side-effects-fetal-neuroprotection-according-to-body-mass-index-after-magnesium-sulfate-in-a-multicenter-randomized-controlled-trial
#13
Gustavo Vilchez, Jing Dai, Moraima Lagos, Robert J Sokol
OBJECTIVE: Evidence supports the need of dose-adjustment of several drugs according to body mass index (BMI) to prevent toxicity in the underweight, and ensure efficacy in obese women. However, for MgSO4 neuroprotection, the effect of BMI on maternal toxicity and fetal neuroprotection is understudied. We analyze the effect of BMI on maternal/infant outcomes after MgSO4. METHODS: Secondary analysis of a clinical trial that studied MgSO4 neuroprotection. Maternal side effects, magnesium cord levels, and offspring cerebral palsy/death were analyzed along BMI strata using ANOVA and chi-square test...
January 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28054741/antileishmanial-activity-and-immunomodulatory-effects-of-tricin-isolated-from-leaves-of-casearia-arborea-salicaceae
#14
Augusto L Santos, Eduardo S Yamamoto, Luiz Felipe D Passero, Márcia D Laurenti, Ligia F Martins, Marta L Lima, Miriam Uemi, Marisi G Soares, João Henrique G Lago, Andre G Tempone, Patricia Sartorelli
Bioactivity-guided fractionation of antileishmanial active extract from leaves of Casearia arborea led to isolation of three metabolites: tricin (1), 1',6'-di-O-β-D-vanilloyl glucopyranoside (2) and vanillic acid (3). Compound 1 demonstrated the highest activity against the intracellular amastigotes of Leishmania infantum, with an IC50 value of 56 μM. Tricin (1) demonstrated selectivity in mammalian cells (SI > 7) and elicited immunomodulatory effect on host cells. The present work suggests that tricin modulated the respiratory burst of macrophages to a leishmanicidal state, contributing to the parasite elimination...
January 5, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28053336/leptin-in-the-interplay-of-inflammation-metabolism-and-immune-system-disorders
#15
REVIEW
Vanessa Abella, Morena Scotece, Javier Conde, Jesús Pino, Miguel Angel Gonzalez-Gay, Juan J Gómez-Reino, Antonio Mera, Francisca Lago, Rodolfo Gómez, Oreste Gualillo
Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role as a central regulator in energy homeostasis has been largely described during the past 20 years. Once secreted into the circulation, leptin reaches the central and peripheral nervous systems and acts by binding and activating the long form of leptin receptor (LEPR), regulating appetite and food intake, bone mass, basal metabolism, reproductive function and insulin secretion, among other processes...
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28052094/association-between-polymorphisms-in-antioxidant-genes-and-inflammatory-bowel-disease
#16
Cristiana Costa Pereira, Cecília Durães, Rosa Coelho, Daniela Grácio, Marco Silva, Armando Peixoto, Paula Lago, Márcia Pereira, Telmo Catarino, Salomé Pinho, João Paulo Teixeira, Guilherme Macedo, Vito Annese, Fernando Magro
Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28033511/vitamin-d-and-alcohol-a-review-of-the-current-literature
#17
REVIEW
Vitor Soares Tardelli, Mariana Pimentel Pádua do Lago, Dartiu Xavier da Silveira, Thiago Marques Fidalgo
Vitamin D is associated with bone mineral density, and its deficiency is a global health problem. In psychiatry, low vitamin D levels have been associated with schizophrenia, depression, psychotic symptoms, and, more recently, alcohol use disorders. Alcohol use disorders are among the most prevalent mental disorders worldwide. Therefore, our aim was to evaluate the association between alcohol use and vitamin D serum levels. The PubMed, SCIELO, and Lilacs databases were searched for this systematic review. We assessed all articles published from 1976 to December 2015, and we examined the associated reference lists to retrieve articles that appeared to fulfill our criteria...
October 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28032738/-diagnosis-and-treatment-of-imported-eosinophilia-in-travellers-and-immigrants-recommendations-of-the-spanish-society-of-tropical-medicine-and-international-health-semtsi
#18
J Salas-Coronas, G Ramírez-Olivencia, J L Pérez-Arellano, M Belhassen-García, C Carranza-Rodríguez, M García-Rodríguez, J Villar-Garcia, B Treviño-Maruri, N Serre-Delcor, R López-Vélez, F Norman, J Gómez-Junyent, M J Soriano-Pérez, G Rojo-Marcos, E Rodríguez de Las Parras, M M Lago-Núñez, A Muro, J Muñoz
According to published data, prevalence of imported eosinophilia among travellers and immigrants is set between 8% and 28.5%. Etiological diagnosis is often troublesome, and depending on the depth of the study and on the population analyzed, a parasitic cause is identified in 17% to 75.9% of the individuals. Among the difficulties encountered to compare studies are the heterogeneity of the studied populations, the type of data collection (prospective/retrospective) and different diagnostic protocols. In this document the recommendations of the expert group of the Spanish Society of Tropical Medicine and International Health (SEMTSI) for the diagnosis and treatment of imported eosinophilia are detailed...
December 29, 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28031288/a-recurrent-p-arg92trp-variant-in-steroidogenic-factor-1-nr5a1-can-act-as-a-molecular-switch-in-human-sex-development
#19
Anu Bashamboo, Patricia A Donohoue, Eric Vilain, Sandra Rojo, Pierre Calvel, Sumudu N Seneviratne, Federica Buonocore, Hayk Barseghyan, Nathan Bingham, Jill A Rosenfeld, Surya Narayan Mulukutla, Mahim Jain, Lindsay Burrage, Shweta Dhar, Ashok Balasubramanyam, Brendan Lee, Marie-Charlotte Dumargne, Caroline Eozenou, Jenifer P Suntharalingham, Ksh de Silva, Lin Lin, Joelle Bignon-Topalovic, Francis Poulat, Carlos F Lagos, Ken McElreavey, John C Achermann
No abstract text is available yet for this article.
December 27, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28028551/structure-based-engineering-of-a-pectate-lyase-with-improved-specific-activity-for-ramie-degumming
#20
Zhanping Zhou, Yang Liu, Zhenying Chang, Huilin Wang, André Leier, Tatiana T Marquez-Lago, Yanhe Ma, Jian Li, Jiangning Song
Biotechnological applications of microbial pectate lyases (Pels) in plant fiber processing are promising, eco-friendly substitutes for conventional chemical degumming processes. However, to potentiate the enzymes' use for industrial applications, resolving the molecular structure to elucidate catalytic mechanisms becomes necessary. In this manuscript, we report the high resolution (1.45 Å) crystal structure of pectate lyase (pelN) from Paenibacillus sp. 0602 in apo form. Through sequence alignment and structural superposition with other members of the polysaccharide lyase (PL) family 1 (PL1), we determined that pelN shares the characteristic right-handed β-helix and is structurally similar to other members of the PL1 family, while exhibiting key differences in terms of catalytic and substrate binding residues...
December 27, 2016: Applied Microbiology and Biotechnology
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