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Ana Ortega, Estefanía Tarazón, Carolina Gil-Cayuela, Luis Martínez-Dolz, Francisca Lago, José Ramón González-Juanatey, Juan Sandoval, Manuel Portolés, Esther Roselló-Lletí, Miguel Rivera
AIMS: Ischaemic cardiomyopathy (ICM) leads to impaired contraction and ventricular dysfunction, causing high rates of morbidity and mortality. Epigenomics allows the identification of epigenetic signatures in human diseases. We analyse the differential epigenetic patterns of the ASB gene family in ICM patients and relate these alterations to their haemodynamic and functional status. METHODS AND RESULTS: Epigenomic analysis was carried out using 16 left ventricular (LV) tissue samples, eight from ICM patients undergoing heart transplantation and eight from control (CNT) subjects without cardiac disease...
April 17, 2018: ESC Heart Failure
Barbara V Lago, Francisco C A Mello, Tairine M Barros, Vinicius M Mello, Livia M Villar, Lia L Lewis-Ximenez, Maria Inês M C Pardini, Elisabeth Lampe
In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti-Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive individuals (55.4% men; mean age 43.1 ± 13.4 years) from 24 of 26 Brazilian states were tested for the presence of anti-Delta antibodies using a commercial immunoassay. Anti-Delta antibodies were detected in 40 samples (3...
April 16, 2018: Journal of Medical Virology
Kehinde S Okunade, Olusola F Olowoselu, Gbemisola E Osanyin, Sarah John-Olabode, Sulaimon A Akanmu, Rose I Anorlu
OBJECTIVE: To investigate the prevalence of maternal selenium deficiency and its effects on pregnancy outcomes in pregnant women with HIV in Lagos, Nigeria. METHODS: The present descriptive cross-sectional study enrolled women aged 15-49 years with HIV who were at 14-26 weeks of a singleton pregnancy and were attending Lagos University Teaching Hospital, Lagos, Nigeria, between August 1, 2016, and April 30, 2017. Participants were selected by consecutive sampling and baseline data were collected through interviews...
April 16, 2018: International Journal of Gynaecology and Obstetrics
Felipe Bisbal, Francisco Alarcón, Angel Ferrero-de-Loma-Osorio, Juan Jose González-Ferrer, Concepción Alonso, Marta Pachón, Helena Tizón, Pilar Cabanas-Grandío, Manuel Sanchez, Eva Benito, Albert Teis, Ricardo Ruiz-Granell, Julián Pérez-Villacastín, Xavier Viñolas, Miguel Angel Arias, Ermengol Vallés, Enrique García-Campo, Ignacio Fernández-Lozano, Roger Villuendas, Lluís Mont
Aims: Left atrial (LA) remodelling is a key determinant of atrial fibrillation (AF) ablation outcome. Optimal methods to assess this process are scarce. LA sphericity is a shape-based parameter shown to be independently associated to procedural success. In a multicentre study, we aimed to test the feasibility of assessing LA sphericity and evaluate its capability to predict procedural outcomes. Methods and results: This study included consecutive patients undergoing first AF ablation during 2013...
April 12, 2018: European Heart Journal Cardiovascular Imaging
Sébastien Bélanger, Stéphanie Paquet-Marceau, Juan Enrique Díaz Lago, François Belzile
In barley, semi-dwarf varieties are attractive for their superior harvest index and lodging resistance, but many semi-dwarf barley genotypes suffer from poor spike emergence. We performed a genetic characterization of a semi-dwarf line (ND23049) that combines short stature, strong stiff culms and adequate spike emergence. We developed a doubled haploid (DH) population derived by crossing ND23049 and the cultivar CLE253. A subset of 88 DH lines and parents were characterized for plant height in 2013 and 2014 and genotyped...
April 15, 2018: Genome Génome / Conseil National de Recherches Canada
Lauren Peterson, Alison Comfort, Laurel Hatt, Thierry van Bastelaer
BACKGROUND: As a growing number of low- and middle-income countries commit to achieving universal health coverage, one key challenge is how to extend coverage to informal sector workers. Micro health insurance (MHI) provides a potential model to finance health services for this population. This study presents lessons from a pilot study of a mandatory MHI plan offered by a private insurance company and distributed through a microfinance bank to urban, informal sector workers in Lagos, Nigeria...
April 15, 2018: International Journal of Health Planning and Management
Karin Sá Fernandes, Marina Gallottini, Talita Castro, Mauricio Flamínio Amato, Juvani Saturno Lago, Paulo Henrique Braz-Silva
Leukemic infiltration of the gingival tissue associated or not with gingival enlargement may be the first manifestation of acute leukemia, despite being rarely reported in the literature. A 10-year-old female patient presented with a 1-month history of an asymptomatic, firm, and pinkish-red generalized gingival overgrowth. There was no bone resorption. Incisional biopsy of the gingival tissue was performed, with histopathological examination revealing a diffuse and hypercellular infiltration of monocytoid cells...
April 12, 2018: Special Care in Dentistry
I González-Veloso, E M Cabaleiro-Lago, J Rodríguez-Otero
The ability of the carbon nanoring [11]cycloparaphenylene ([11]CPP) for coordinating fullerenes has been tested using a series of hosts, including the pristine fullerenes C60, C70, C76 and C78, the clusterfullerene Sc3N@C80, monometallic endofullerenes Y@C82 and Tm@C82, and dimetallic endofullerenes Y2@C82 and Lu2@C82. A systematic theoretical study employing dispersion corrected density functional methods has been carried out in order to explore the characteristics of the complexes and the strength of the interaction...
April 12, 2018: Physical Chemistry Chemical Physics: PCCP
Víctor Patricio Díaz-Narváez, Ana Cristina Amezaga-Avitia, Pablo Alexander Sarabia-Alvarez, Macarena Lagos-Elgueta, Monserrat Saavedra-Madrid, Pablo Silva-Reyes, Mariela Padilla, María Paz Rodríguez-Hopp
Objectives: To estimate the general empathy levels and the potential for empathic growth in Dentistry students and demonstrate that the empathic erosion model is not med. Material and methods: Exploratory and cross-sectional study. Population: First- to fifth-year Dentistry students at Universidad San Sebastián, Santiago Campus (Chile). The total student population (N) was 800. The participants completed the Jefferson Scale of Empathy in its Spanish version for medical students, validated and adapted in Chile...
April 2018: Saudi Dental Journal
Gorka Nagore, Jose Luis Lopez Guerra, Evita Krumina, Mark Lagos, Beatriz Ovalles, Antonio Miró, Lourdes Beltran, Emilia Gómez, Juan Manuel Praena-Fernandez, Eleonor Rivin Del Campo, Ignacio Azinovic, Alfonso Gomez-Iturriaga
BACKGROUND AND PURPOSE: High dose-rate (HDR) brachytherapy (BT) provides a highly conformal method of dose delivery to the prostate. The purpose of this study is to prospectively determine the toxicity of the treatment protocol of 13.5 Gy × 2 fractions. MATERIALS AND METHODS: From 2010 through 2017, 119 patients with low (71%) or intermediate-risk prostate cancer were prospectively treated in a single institute with HDR-BT at 13.5 Gy × 2 fractions within one day...
April 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Vinicius S Londero, Thais A da Costa-Silva, Kaio S Gomes, Daiane D Ferreira, Juliana T Mesquita, Andre G Tempone, Maria Claudia M Young, Gerold Jerz, João Henrique G Lago
Porcelia macrocarpa (Warm.) R. E. Fries (Annonaceae) is an endemic plant in Brazil where its tasty pulp has been eaten fresh. The hexane extract from its flowers was subjected to chromatographic procedures to afford four acetylene derivatives identified as octadec-9-ynoic (stearolic acid - 1), (11E)-octadec-11-en-9-ynoic (santalbic acid - 2), 8-hydroxyoctadec-9,11-diynoic (3) and 8-hydroxyoctadec-17-en-9,11-diynoic (isanolic acid - 4) acids by NMR and HRESIMS. Among tested compounds against trypomastigote forms of T...
March 30, 2018: Bioorganic Chemistry
Gisela Paula González, Nebel Silvana Moscoso, Fernando Pablo Lago
Schizophrenia is considered a serious mental disorder that affects over 21 million people worldwide, and is associated with disability that frequently affects the patient's educational and working performance. In Argentina, two of the most widely used antipsychotics in the treatment of this disorder are haloperidol and risperidone. Both are provided free to patients without health coverage in public healthcare facilities. In this paper we seek to review the clinical and economic benefits of prescribing psychotropic therapies based on haloperidol (a first-generation antipsychotic that is part of the butyrophenone group of drugs) versus risperidone [an atypical or second-generation antipsychotic (neuroleptic) drug] in adult patients who have been diagnosed with schizophrenia...
October 23, 2017: PharmacoEconomics Open
Cristian A Carvajal, Alejandra Tapia-Castillo, Carolina P Valdivia, Fidel Allende, Sandra Solari, Carlos F Lagos, Carmen Campino, Alejandro Martínez-Aguayo, Andrea Vecchiola, Constanza Pinochet, Claudia Godoy, Virginia Iturrieta, Rene Baudrand, Carlos E Fardella
Background: Pathogenic variations in HSD11B2 gene triggers the apparent mineralocorticoid excess syndrome (AME). There is scarce information regarding the phenotypes of subjects carrying heterozygous pathogenic variants in HSD11B2 gene. We investigated if serum cortisol/cortisone(F/E) ratio and cortisone are useful for identifying partial 11βHSD2 deficiency in those heterozygous subjects. Methods: We studied two patients diagnosed with AME and their families carrying either D223N or R213C mutation...
March 30, 2018: American Journal of Hypertension
Mateo Prochazka, Larissa Otero, Kelika A Konda, Elsa González-Lagos, Juan Echevarría, Eduardo Gotuzzo
Patient-nominated supporters can potentially improve the continuum of HIV care. We retrospectively determined factors associated with having a patient-nominated supporter among people living with HIV (PLWH), and its association with retention in care and viral suppression. We analysed registries of adults evaluated by social workers (n = 1345) at a referral hospital in Peru between 2011-2014. Nondisclosure of HIV status was associated with lacking supporters (aPR: 5.41, 95% CI: 3.83-7.64). Retention in care was 76...
2018: PloS One
Mercedes Fernández, Laura Lago, M Gema Alonso, Ana Guede, Jose Luis Benavente, Jose M Olivares
No abstract text is available yet for this article.
March 2018: Actas Españolas de Psiquiatría
Obianuju B Ozoh, Tochi J Okwor, Olorunfemi Adetona, Ayesha O Akinkugbe, Casmir E Amadi, Christopher Esezobor, Olufunke O Adeyeye, Oluwafemi Ojo, Vivian N Nwude, Kevin Mortimer
Cooking with dirty-burning fuels is associated with health risk from household air pollution. We assessed the prevalence of and factors associated with the use of cooking fuels, and attitudes and barriers towards use of liquefied petroleum gas (LPG). This was a cross-sectional, population-based survey conducted in 519 households in Lagos, Nigeria. We used a structured questionnaire to obtain information regarding choice of household cooking fuel and the attitudes towards the use of LPG. Kerosene was the most frequently used cooking fuel ( n = 475, 91...
March 31, 2018: International Journal of Environmental Research and Public Health
Franca Ogechi Iheonu, Iretiola Bamikeolu Fajolu, Chinyere Veronica Ezeaka, Wellington Aghoghovwia Oyibo
BACKGROUND AND OBJECTIVES: Sick neonates in malaria endemic areas are frequently transfused with donor blood unscreened for malaria parasite. Consequently, they are at risk of transfusional malaria which can lead to increased neonatal mortality. The study aimed to determine the burden of transfusional malaria in neonates to help in policy formulation on prevention of transfusional malaria. MATERIALS AND METHODS: One hundred and sixty four neonates admitted into the neonatal unit of a tertiary hospital over a 10 month period who were scheduled for blood transfusion were screened for malaria parasites pre-transfusion, at three and 14 days post transfusion using Giemsa stained thick and thin films...
2018: PloS One
Yago Arosa, Elena López Lago, Raúl de la Fuente
White light spectral interferometry is applied to measure the refractive index in absorbing liquids in the spectral range of 400-1000 nm. We analyze the influence of absorption on the visibility of interferometric fringes and, accordingly, on the measurement of the refractive index. Further, we show that the refractive index in the absorption band can be retrieved by a two-step process. The procedure requires the use of two samples of different thickness, the thicker one to retrieve the refractive index in the transparent region and the thinnest to obtain the data in the absorption region...
March 19, 2018: Optics Express
Gabriel A Leiva-Valenzuela, Marcela Quilaqueo, Daniela Lagos, Danilo Estay, Franco Pedreschi
The aim of this research was to determine the effect of composition (dietary fiber = DF, fat = F, and gluten = G) and baking time on the target microstructural parameters that were observed using images of potato and wheat starch biscuits. Microstructures were studied Scanning Electron Microscope (SEM). Non-enzymatic browning (NEB) was assessed using color image analysis. Texture and moisture analysis was performed to have a better understanding of the baking process. Analysis of images revealed that the starch granules retained their native form at the end of baking, suggesting their in complete gelatinization...
April 2018: Journal of Food Science and Technology
Carine Mainzer, Noëlle Remoué, Jennifer Molinari, Patricia Rousselle, Carla Barricchello, Juliana C Lago, Pascal Sommer, Dominique Sigaudo-Roussel, Romain Debret
Aging is a complex multifaceted process affecting skin functionality and structure. Several 3D organotypic skin culture models have reproduced aging by inducing replicative senescence, glycation or oxidative stress. Yet, very few models have focused on hormonal aging and especially the insulin-like growth factor 1 (IGF-1) signaling pathway, which has been associated to longevity in animal studies and is necessary in the early stages of skin development. In this study, we built an organotypic epidermis model with targeted IGF-1 receptor knockdown to reproduce some aspects of hormonal aging on skin...
March 30, 2018: Experimental Dermatology
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