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https://www.readbyqxmd.com/read/29457826/prevalence-of-cardiometabolic-risk-factors-among-professional-male-long-distance-bus-drivers-in-lagos-south-west-nigeria-a-cross-sectional-study
#1
Casmir E Amadi, Tim P Grove, Amam C Mbakwem, Obianuju B Ozoh, Oyewole A Kushimo, David A Wood, Michael Akinkunmi
BACKGROUND: Professional drivers are known to be at high risk of cardiovascular disease (CVD). This study was carried out to highlight these risk factors and their predictors among male long-distance professional bus drivers in Lagos, south-west Nigeria, with a view to improving health awareness in this group. METHOD: Socio-demographic data, anthropometric indices, blood pressure, fasting plasma blood glucose levels and lipid and physical activity profiles of 293 drivers were measured...
February 19, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29456825/multi-stakeholder-perspectives-on-access-availability-and-utilization-of-emergency-obstetric-care-services-in-lagos-nigeria-a-mixed-methods-study
#2
Aduragbemi Banke-Thomas, Kikelomo Wright, Olatunji Sonoiki, Onaedo Ilozumba, Babatunde Ajayi, Olawunmi Okikiolu, Oluwarotimi Akinola
Globally, Nigeria is the second most unsafe country to be pregnant, with Lagos, its economic nerve center having disproportionately higher maternal deaths than the national average. Emergency obstetric care (EmOC) is effective in reducing pregnancyrelated morbidities and mortalities. This mixed-methods study quantitatively assessed women's satisfaction with EmOC received and qualitatively engaged multiple key stakeholders to better understand issues around EmOC access, availability and utilization in Lagos...
December 31, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/29456684/capn3-dct-mlana-and-tyrp1-are-overexpressed-in-skin-of-vitiligo-vulgaris-mexican-patients
#3
Mauricio Salinas-Santander, Víctor Trevino, Eduardo De la Rosa-Moreno, Bárbara Verduzco-Garza, Celia N Sánchez-Domínguez, Cristina Cantú-Salinas, Jorge Ocampo-Garza, Armando Lagos-Rodríguez, Jorge Ocampo-Candiani, Rocio Ortiz-López
Vitiligo is a disorder causing skin depigmentation, in which several factors have been proposed for its pathogenesis: Environmental, genetic and biological aspects of melanocytes, even those of the surrounding keratinocytes. However, the lack of understanding of the mechanisms has complicated the task of predicting the development and progression. The present study used microarray analysis to characterize the transcriptional profile of skin from Vitiligo Vulgaris (VV) patients and the identified transcripts were validated using targeted high-throughput RNA sequencing in a broader set of patients...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456226/three-cases-of-prune-belly-syndrome-at-the-lagos-state-university-teaching-hospital-ikeja
#4
Adaobi U Solarin, Elizabeth A Disu, Henry O Gbelee, Adeola B Animasahaun, Oluwatosin E Aremu, Eucharia Ogbuokiri, Gbemisola O Ogunnaike, Alaba Oladimeji
Prune belly syndrome (PBS) is a rare congenital disorder affecting 2.5 to 3.8/100,000 live births worldwide. Our objective of this report is to describe clinical manifestation, laboratory, and radiological characteristics of PBS in our patients, to highlight the limitations to offering appropriate patient care due to parents demanding discharge against medical advice and the need to increase the awareness regarding this rare disease. We report three cases; all referred after birth with lax abdominal wall, congenital anomalies of kidney, and urinary tract...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456097/the-timing-of-early-therapeutic-strategies-has-a-significant-impact-on-crohn-s-disease-prognosis
#5
Cláudia Camila Dias, Francisco Portela, Samuel Fernandes, Paula Ministro, Paula Lago, Isadora Rosa, Luis Correia, Fernando Magro
BACKGROUND: Abdominal surgery and immunosuppressive pharmacological treatments are two different therapeutic options used to manage Crohn disease. This study aimed to determine whether the timing of these interventions had an impact on patients' prognosis. METHOD: This manuscript entails a retrospective analysis of a multicentric cohort involving 498 CD patients that had bowel surgery after diagnosis and prior to immunosuppression treatments. Two endpoints were considered: the occurrence of disabling disease and the need to undergo further bowel surgeries...
February 1, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29451106/thinking-in-a-foreign-language-reduces-the-causality-bias
#6
Marcos Díaz-Lago, Helena Matute
The purpose of this research is to investigate the impact of a foreign language on the causality bias (i.e., the illusion that two events are causally related when they are not). We predict that using a foreign language could reduce the illusions of causality. A total of 36 native English speakers participated in Experiment 1, 80 native Spanish speakers in Experiment 2. They performed a standard contingency learning task, which can be used to detect causal illusions. Participants who performed the task in their native tongue replicated the illusion of causality effect, whereas those performing the task in their foreign language were more accurate in detecting that the two events were causally unrelated...
February 1, 2018: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/29448019/recovery-of-black-necked-swans-macrophytes-and-water-quality-in-a-ramsar-wetland-of-southern-chile-assessing-resilience-following-sudden-anthropogenic-disturbances
#7
Eduardo Jaramillo, Nelson A Lagos, Fabio A Labra, Enrique Paredes, Emilio Acuña, Daniel Melnick, Mario Manzano, Carlos Velásquez, Cristian Duarte
In 2004 migration and mortality for unknown reasons of the herbivorous Black necked swan (Cygnus melancorhyphus (Molina, 1782)) occurred within the Río Cruces wetland (southern Chile), a Ramsar Site and nature sanctuary. Before 2004, this wetland hosted the largest breeding population of this water bird in the Neotropic Realm. The concurrent decrease in the spatial occurrence of the aquatic plant Egeria densa Planch. 1849 - the main food source of swans - was proposed as a cause for swan migration and mortality...
February 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29447232/hepatitis-b-virus-genotypes-a1-a2-and-e-in-cape-verde-unequal-distribution-through-the-islands-and-association-with-human-flows
#8
Isabel Inês M de Pina-Araujo, Natalia Spitz, Caroline C Soares, Christian Niel, Barbara V Lago, Selma A Gomes
Hepatitis B virus (HBV) diversity has not been previously studied in Cape Verde. The archipelago was discovered in 1460 by Portuguese explorers, who brought African slaves to colonise the islands. In this study, we investigated the HBV characteristics from 183 HBsAg-positive Cape Verdean individuals. Phylogenetic analysis of the pre-S/S region and the full-length genomes revealed 54 isolates with HBV/A1 (57%), 21 with HBV/A2 (22%), 19 with HBV/E (20%), and one with HBV/D (1%). HBV genotypes and subgenotypes were unequally distributed through the islands...
2018: PloS One
https://www.readbyqxmd.com/read/29433963/pertuzumab-and-trastuzumab-with-or-without-metronomic-chemotherapy-for-older-patients-with-her2-positive-metastatic-breast-cancer-eortc-75111-10114-an-open-label-randomised-phase-2-trial-from-the-elderly-task-force-breast-cancer-group
#9
Hans Wildiers, Konstantinos Tryfonidis, Lissandra Dal Lago, Peter Vuylsteke, Giuseppe Curigliano, Simon Waters, Barbara Brouwers, Sevilay Altintas, Nathan Touati, Fatima Cardoso, Etienne Brain
BACKGROUND: Despite the high incidence of metastatic breast cancer and its related mortality in the elderly population, our knowledge about optimal treatment for older patients with cancer is far from adequate. We aimed to evaluate the efficacy of dual anti-HER2 treatment with or without metronomic chemotherapy in older patients with HER2-positive metastatic breast cancer. METHODS: We did a multicentre, open-label, randomised, phase 2 trial in 30 centres from eight countries in Europe, in patients with histologically proven, HER2-positive metastatic breast cancer, without previous chemotherapy for metastatic disease, who were 70 years or older, or 60 years or older with confirmed functional restrictions defined by protocol, and had a life expectancy of more than 12 weeks and a performance status according to WHO scale of 0-3...
February 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29433370/vitamin-d-deficiency-in-pregnant-women-and-newborns-in-lagos-nigeria
#10
Emmanuel Owie, Bosede Bukola Afolabi
We aimed to determine the prevalence of Vitamin D deficiency among pregnant women and their newborns in order to make recommendations for Vitamin D supplementation, if necessary. It was a cross-sectional study carried out over a period of 12 months. Information such as use of Vitamin D supplements, number of daytime hours spent outdoors and dressing style was obtained from 166 pregnant women in Lagos, Nigeria; maternal and cord blood 25(OH)D concentration was determined using ELISA. The prevalence of Vitamin D deficiency (<20 ng/mL) in the mothers and newborns was 4...
February 13, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29433197/corrigendum-to-dehydration-of-jambolan-syzygium-cumini-l-juice-during-foam-mat-drying-quantitative-and-qualitative-changes-of-the-phenolic-compounds-food-research-international-102-2017-32-42
#11
Iasnaia Maria de Carvalho Tavares, Tuany Yuri Kuboyama Nogueira, Maria Aparecida Mauro, Sergio Gómez-Alonso, Eleni Gomes, Roberto Da-Silva, Isidro Hermosín-Gutiérrez, Ellen Silva Lago-Vanzela
No abstract text is available yet for this article.
March 2018: Food Research International
https://www.readbyqxmd.com/read/29432673/anticounterfeiting-strategies-of-local-drug-manufacturers-in-lagos-nigeria-implications-for-public-health
#12
Olufinsho Awodele, Samson Fatoki
BACKGROUND: Nigeria has been plagued by counterfeit and poor quality medicines with several studies indicating varying degree of prevalence. Thus, this study is aimed at determining the anticounterfeiting strategies employed by local drug manufacturers in Lagos-Nigeria. METHOD: The first phase was a descriptive study which involves the use of a self-administered closed ended structured questionnaire to assess the anticounterfeiting strategies employed by local manufacturers in Nigeria...
December 4, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/29428428/eosinophilic-granulomatosis-with-polyangiitis-a-case-report
#13
Alicia Martín-Lagos Maldonado, Sara Pérez Moyano, Tania Gallart Aragón
No abstract text is available yet for this article.
February 7, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29426498/capillary-zone-electrophoresis-method-to-assay-tipranavir-capsules-and-identification-of-oxidation-product-and-organic-impurity-by-quadrupole-time-of-flight-mass-spectrometry
#14
Matheus Wagner Lago, Mariane Lago Friedrich, Gabrielle Dineck Iop, Thiago Belarmino de Souza, Paola de Azevedo Mello, Andréa Inês Horn Adams
Tipranavir (TPV) is one of the most recently developed protease inhibitors (PI) and it is specially recommended for treatment-experienced patients who are resistant to other PI drugs. In this work, a simple and friendly environmental CZE stability-indicating method to assay TPV capsules was developed and two TPV organic impurities were identified by high resolution mass spectrometry (HRMS). The optimized analytical conditions were: background electrolyte composed of sodium borate 50mM, pH 9.0 and 5% of methanol; voltage + 28kV; hydrodynamic injection of 5s (100mbar), detection wavelength 240nm, at 25°C...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29424410/-diabetes-mellitus-caused-by-a-mutation-of-glucokinase-gene-report-of-an-affected-family
#15
Felipe Pollak C, Marcela Lagos L, José L Santos M, Helena Poggi, Abraham Urzúa C, Hana Rumié C
Maturity-Onset Diabetes of the Young (MODY) refers to a heterogeneous group of monogenic diabetes. Unlike other types of MODY characterized by genetic defects in transcription factors, MODY 2 is triggered by metabolic alterations caused by mutations of glucokinase (GCK), the first enzyme of the glycolytic pathway. We report a three-generation Chilean family with multiple cases affected with this disease. The index case is a patient who presented severe neonatal hyperglycemia (831 mg/dl, without ketosis) requiring continuous infusion of insulin, which was suspended after 48 hours with normalization of blood glucose...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29424240/report-of-in-vitro-antileishmanial-properties-of-iberian-macroalgae
#16
Carolina Bruno de Sousa, João Henrique G Lago, Jorge Macridachis, Marta Oliveira, Luis Brito, Catarina Vizetto-Duarte, Cláudia Florindo, Sarah Hendrickx, Louis Maes, Thiago Morais, Miriam Uemi, Luís Neto, Lídia Dionísio, Sofia Cortes, Luísa Barreira, Luísa Custódio, Fernando Alberício, Lenea Campino, João Varela
Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8-101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5...
February 9, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29421586/immunological-response-of-the-sub-antarctic-notothenioid-fish-eleginops-maclovinus-injected-with-two-strains-of-piscirickettsia-salmonis
#17
D Martínez, D Díaz-Ibarrola, C Vargas-Lagos, R Oyarzún, J P Pontigo, J L P Muñoz, A J Yáñez, L Vargas-Chacoff
Eleginops maclovinus is an endemic fish to Chile that lives in proximity to salmonid culture centers, feeding off of uneaten pellet and salmonid feces. Occurring in the natural environment, this interaction between native and farmed fish could result in the horizontal transmission of pathogens affecting the aquaculture industry. The aim of this study was to evaluate the innate and adaptive immune responses of E. maclovinus challenged with P. salmonis. Treatment injections (in duplicate) were as follows: control (100 μL of culture medium), wild type LF-89 strain (100 μL, 1 × 108 live bacteria), and antibiotic resistant strain Austral-005 (100 μL, 1 × 108 live bacteria)...
February 5, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29419665/the-effects-of-physical-therapy-with-neuromuscular-electrical-stimulation-in-patients-with-septic-shock-study-protocol-for-a-randomized-cross-over-design
#18
RANDOMIZED CONTROLLED TRIAL
Alessandra Fabiane Lago, Anamaria Siriani de Oliveira, Hugo Celso Dutra de Souza, João Santana da Silva, Anibal Basile-Filho, Ada Clarice Gastaldi
INTRODUCTION: Septic shock is a potentially fatal organ dysfunction caused by an imbalance of the host response to infection. The changes in microcirculation during sepsis can be explained by the alterations in the endothelial barrier function. Endothelial progenitor cells (EPCs) are a potential recovery index of endothelial function and it an increase in response to neuromuscular electrical stimulation (NMES) was demonstrated. Therefore, the objective of this study is to investigate the effects of NMES in patients with septic shock...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29416959/socioeconomic-status-health-inequalities-and-non-communicable-diseases-a-systematic-review
#19
REVIEW
Santiago Lago, David Cantarero, Berta Rivera, Marta Pascual, Carla Blázquez-Fernández, Bruno Casal, Francisco Reyes
Aim: A comprehensive approach to health highlights its close relationship with the social and economic conditions, physical environment and individual lifestyles. However, this relationship is not exempt from methodological problems that may bias the establishment of direct effects between the variables studied. Thus, further research is necessary to investigate the role of socioeconomic variables, their composition and distribution according to health status, particularly on non-communicable diseases...
2018: Journal of Public Health
https://www.readbyqxmd.com/read/29415255/validation-of-the-united-registries-for-clinical-assessment-and-research-ur-care-a-european-online-registry-for-clinical-care-and-research-in-inflammatory-bowel-disease
#20
Johan Burisch, Javier P Gisbert, Britta Siegmund, Dominik Bettenworth, Sandra Bohn Thomsen, Isabelle Cleynen, Anneline Cremer, Nik John Sheng Ding, Federica Furfaro, Michail Galanopoulos, Philip Christian Grunert, Jurij Hanzel, Tamara Knezevic Ivanovski, Eduards Krustins, Nurulamin Noor, Neil O'Morain, Iago Rodríguez-Lago, Michael Scharl, Julia Tua, Mathieu Uzzan, Nuha Ali Yassin, Filip Baert, Ebbe Langholz
Background: The "United Registries for Clinical Assessment and Research" (UR-CARE) database is an initiative of the European Crohn's and Colitis Organisation (ECCO) to facilitate daily patient care and research studies in inflammatory bowel disease (IBD). Herein, we sought to validate the database by using fictional case histories of patients with IBD that were to be entered by observers of varying experience in IBD. Methods: A total of 19 observers entered 5 patient case histories into the database...
February 3, 2018: Journal of Crohn's & Colitis
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