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Eloi M Lago, Rogério P Xavier, Thaina R Teixeira, Lívia M Silva, Ademar A da Silva Filho, Josué de Moraes
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost 40 years. The pressing need to develop a new antischistosomal drug may necessitate exploring and filtering chemotherapeutic history to search for the most promising ones. In this context, this review attempts to summarize all progress made in schistosomiasis chemotherapy from the early 20th century (mid-1910s) to 2016. We gathered almost 100 compounds providing information on therapeutic action, specifically covering at least first in vivo studies in animal model and in vitro...
December 13, 2017: Future Medicinal Chemistry
Ronza Hadad, Daniel Golparian, Amaya C Lagos, Johan Ljungberg, Peter Nilsson, Jörgen S Jensen, Hans Fredlund, Magnus Unemo
Mycoplasma genitalium, causing non-gonococcal non-chlamydial urethritis and associated with cervicitis, has developed antimicrobial resistance (AMR) to both the macrolide azithromycin (first-line treatment) and the fluoroquinolone moxifloxacin (second-line treatment). Our aim was to estimate the prevalence of resistance, based on genetic AMR determinants, to these antimicrobials in the M. genitalium population in two Swedish counties, Örebro and Halland, 2011-2015. In total, 672 M. genitalium positive urogenital samples were sequenced for 23S rRNA and parC gene mutations associated with macrolide and fluoroquinolone resistance, respectively...
December 13, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
D Pagliari, A Saviano, M L Serricchio, A A Dal Lago, M G Brizi, R Manfredi, G Costamagna, F Attili
Pancreatic cystosis is a rare presentation of cystic fibrosis involving pancreatic gland. To date, only very few cases of pancreatic cystosis have been described in literature. Pancreatic cystosis may begin during the second decade of life and is the rarest presentation of cystic fibrosis. This disease is characterized by the presence of multiloculated cysts without ductal system communication of different sizes in all the pancreatic tissue. Herein, we report a case of a young woman affected by cystic fibrosis that was admitted to our Pancreatic Centre to evaluate a picture of diffuse multiloculated pancreatic cysts...
November 2017: European Review for Medical and Pharmacological Sciences
José Alcides Almeida de Arruda, Leni Verônica de Oliveira Silva, Camila de Nazaré Alves de Oliveira Kato, Lauren Frenzel Schuch, Aline Carvalho Batista, Nádia Lago Costa, Sandra Beatriz Chaves Tarquinio, Elena Riet Correa Rivero, Vinícius Coelho Carrard, Manoela Domingues Martins, Ana Paula Veras Sobral, Ricardo Alves Mesquita
OBJECTIVES: To investigate the frequency of malignant oral and maxillofacial lesions among children and adolescents from representative geographic regions of Brazil. MATERIALS AND METHODS: A retrospective study was conducted on biopsies obtained from 1990 to 2016 at six Brazilian oral and maxillofacial pathology referral centers. A total of 85,105 biopsy specimens from children and adolescents were analyzed. Gender, age, anatomical location, symptomatology and histopathological diagnosis were evaluated...
December 2017: Oral Oncology
Ling Li, Pablo Diaz-Brage, Helena Fernandez-Lago, Noa Fogelson
We investigated the effects of implicit versus explicit local contextual processing in Parkinson's disease (PD) using electrophysiological measures. EEG recording blocks consisted of targets preceded by either randomized sequences of standards or by sequences including a predictive sequence signaling the occurrence of a target event. PD patients ("on" medication) and healthy controls performed two sessions: in the first the regularity of the predictive sequence was implicit, while in the second this regularity was made explicit...
December 5, 2017: Neuropsychologia
Rúbia S Costa, Lucas P Carvalho, Taís M Campos, Andréa S Magalhães, Sara T Passos, Albert Schriefer, Juliana A Silva, Ednaldo Lago, Camilla S Paixão, Paulo Machado, Phillip Scott, Edgar M Carvalho
Background: Early cutaneous leishmaniasis (ECL) is characterized by a non-ulcerated papular lesion and illness duration less than 30 days. About 4 weeks later the cutaneous leishmaniasis (CL) ulcers appear. Surprisingly, failure following antimony therapy (Sb5) is higher in ECL than CL. We hypothesize that the inflammatory response in ECL patients may increase during Sb5 therapy leading to treatment failure. Methods: A cohort of 44 ECL patients infected by Leishmaniabraziliensis was established to evaluate the response to Sb5, and to compare immunologic responses in ECL patients with CL and healthy subjects (HS)...
December 6, 2017: Journal of Infectious Diseases
Michael O N Kunnuji, Rachel Sullivan Robinson, Yusra Ribhi Shawar, Jeremy Shiffman
In 2003, Nigeria adopted the Family Life and HIV Education (FLHE) sexuality education curriculum. Our analysis interrogates variation in sub-national implementation. We conducted 52 interviews with persons knowledgeable about the curriculum in three states-Kano, Lagos, and Niger-and reviewed publications on FLHE. In Kano, the socio-cultural context impeded implementation, but the persistence of innovative local champions resulted in some success. In Lagos, the cosmopolitan context, effective champions, funding by international donors, and a receptive government bureaucracy led to successful implementation...
December 2017: Studies in Family Planning
A Ademuyiwa, F Alakaloko, O Elebute, C Bode, I Udenze
BACKGROUND/PURPOSE: Serum Intestinal Fatty-Acid Binding Protein (I-FABP) is a useful marker of bowel necrosis in pediatric intussusception. The aim of this study is to determine the sensitivity of this marker and correlate it with length of necrosed small bowel. METHODS: A single-centre prospective study of 50 children presenting to Lagos University Teaching Hospital, Nigeria, in whom a diagnosis of intussusception was made over 1 year was completed. Additionally, 25 age- and sex-matched controls (day case surgery) were recruited...
November 14, 2017: Journal of Pediatric Surgery
Mehmet Isik, Luca Porcarelli, Nerea Lago, Haijin Zhu, Maria Forsyth, David Mecerreyes
Proton conducting polymeric membranes are highly searched in many different technologies ranging from energy to biosensing. Protic ionic liquids and their polymeric version represent a new family of proton conducting molecules with relatively facile synthesis and excellent properties. In this work, protic poly(ionic liquids) having the most popular phosphonium counter-cations are presented for the first time. The synthesis is carried out through proton transfer reactions or through ion exchange reactions by using commercially available tertiary phosphines...
December 4, 2017: Macromolecular Rapid Communications
Tavares Iasnaia Maria de Carvalho, Tuany Yuri Kuboyama Nogueira, Maria Aparecida Mauro, Sergio Gómez-Alonso, Eleni Gomes, Roberto Da-Silva, Isidro Hermosín-Gutiérrez, Ellen Silva Lago-Vanzela
Jambolan [Syzygium cumini (L.)] berries are a popular fruit in Brazil, renowned for their high phenolic compound (PC) content. These PCs have antioxidant, antibacterial, and other characteristics that may be beneficial to human health. The objective of the study was to evaluate the quantitative and qualitative changes of the main phenolic compounds (PCs) (anthocyanins, flavonols, and hydrolysable tannins) in the jambolan fruit, the produced fruit juice, and in the corresponding dehydrated powders obtained by foam mat drying (60, 70, and 80°C) and lyophilization (control)...
December 2017: Food Research International
Leidy Lagos, Julia Tandberg, Alexander Kashulin-Bekkelund, Duncan J Colquhoun, Henning Sørum, Hanne C Winther-Larsen
Secretion of extracellular vesicles (EVs) is a common feature of both eukaryotic and prokaryotic cells. Isolated EVs have been shown to contain different types of molecules, including proteins and nucleic acids, and are reported to be key players in intercellular communication. Little is known, however, of EV secretion in fish, or the effect of infection on EV release and content. In the present study, EVs were isolated from the serum of healthy and Piscirickettsia salmonis infected Atlantic salmon in order to evaluate the effect of infection on EV secretion...
December 1, 2017: Proteomes
Jiawei Wang, Bingjiao Yang, Yi An, Tatiana Marquez-Lago, André Leier, Jonathan Wilksch, Qingyang Hong, Yang Zhang, Morihiro Hayashida, Tatsuya Akutsu, Geoffrey I Webb, Richard A Strugnell, Jiangning Song, Trevor Lithgow
In the course of infecting their hosts, pathogenic bacteria secrete numerous effectors, namely, bacterial proteins that pervert host cell biology. Many Gram-negative bacteria, including context-dependent human pathogens, use a type IV secretion system (T4SS) to translocate effectors directly into the cytosol of host cells. Various type IV secreted effectors (T4SEs) have been experimentally validated to play crucial roles in virulence by manipulating host cell gene expression and other processes. Consequently, the identification of novel effector proteins is an important step in increasing our understanding of host-pathogen interactions and bacterial pathogenesis...
November 27, 2017: Briefings in Bioinformatics
Camila Carvalho Lago, Caciano P Zapata Noreña
This study aimed to investigate the kinetics and thermodynamic of the phenolics degradation and the kinetics of degradation of the total color difference of yacon juice microcapsules produced by spray drying using Gum Arabic and polydextrose as wall materials. The degradation of the microcapsule was evaluated by accelerated tests under controlled conditions at 35 and 45 °C, and relative humidity of 75 and 90%, for 35 days. Degradation of phenolics followed the first order model and the degradation constant was in the range of 0...
December 2017: Journal of Food Science and Technology
María Elena Lagos G, Alide Salazar M, Patricio Salas F
BACKGROUND: The Patient Assessment of Chronic Illness Care (PACIC) questionnaire is a widely used instrument to assess chronic disease care from a patient's perspective. AIM: To adapt the PACIC questionnaire to Chilean Spanish and to evaluate the psychometric properties of the translation. MATERIAL AND METHODS: Descriptive, cross-sectional design with exploratory and confirmatory factor analysis. The PACIC questionnaire was applied, throughout an external client, to 200 users who received health care at the cardiovascular program in a Family Health Center in Concepción, Chile...
July 2017: Revista Médica de Chile
Abiodun Musbau Lawal, Benjamin Oladapo Olley
Long distance truck drivers (LDTDs) have been identified as one of the groups at higher risk for human immunodeficiency virus (HIV) infection. Understanding how certain social and psychological variables that have a strong theoretical basis contribute to sexual risk behaviour will guide in the implementation process of HIV risk-reduction intervention in the trucking population. In line with the conceptualisation of Information, Motivation and Behavioural skills model, we examined the extent that HIV knowledge, attitude towards condom use, peer support to condom use, perceived vulnerability to HIV/AIDS, and condom use self-efficacy will independently and jointly explain sexual risk behaviours of LDTDs in a haulage company in Lagos, Nigeria...
December 2017: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
Miguel A Lago, Craig K Abbey, Miguel P Eckstein
We evaluate 3D search requires model observers that take into account the peripheral human visual processing (foveated models) to predict human observer performance. We show that two different 3D tasks, free search and location-known detection, influence the relative human visual detectability of two signals of different sizes in synthetic backgrounds mimicking the noise found in 3D digital breast tomosynthesis. One of the signals resembled a microcalcification (a small and bright sphere), while the other one was designed to look like a mass (a larger Gaussian blob)...
February 11, 2017: Proceedings of SPIE
Miguel P Eckstein, Miguel A Lago, Craig K Abbey
The field of medical image quality has relied on the assumption that metrics of image quality for simple visual detection tasks are a reliable proxy for the more clinically realistic visual search tasks. Rank order of signal detectability across conditions often generalizes from detection to search tasks. Here, we argue that search in 3D images represents a paradigm shift in medical imaging: radiologists typically cannot exhaustively scrutinize all regions of interest with the high acuity fovea requiring detection of signals with extra-foveal areas (visual periphery) of the human retina...
February 11, 2017: Proceedings of SPIE
Jean P Boubli, Maria N F da Silva, Anthony B Rylands, Stephen D Nash, Fabrício Bertuol, Mário Nunes, Russell A Mittermeier, Hazel Byrne, Felipe E da Silva, Fábio Röhe, Iracilda Sampaio, Horacio Schneider, Izeni P Farias, Tomas Hrbek
The pygmy marmoset, Cebuella pygmaea, the smallest of the New World monkeys, has one of the largest geographical distributions of the Amazonian primates. Two forms have been recognized: Cebuella pygmaea pygmaea (Spix, 1823), and C. p. niveiventrisLönnberg, 1940. In this study, we investigated if the separation of pygmy marmosets into these two clades can be corroborated by molecular data. We also examine and compare coloration of the pelage in light of the new molecular results. We analyzed the mtDNA cytochrome b gene and, for the first time for any Neotropical primate, we used a reduced representation genome sequencing approach (ddRADseq) to obtain data for recently collected, geographically representative samples from the Rio Japurá, a northern tributary of the Rio Solimões and from the Javarí, Jutaí, Juruá, Madeira and Purus river basins, all tributaries south of the Solimões...
November 23, 2017: Molecular Phylogenetics and Evolution
Javier Martínez-Sanz, María Rosa Lago-Gómez, María Elena Rodríguez-Zurita, Esteban Martín-Echevarría, Miguel Torralba
BACKGROUND AND OBJECTIVE: Our objective is to analyze the incidence of tuberculosis (TB) in our population and to compare the characteristics of patients with and without HIV infection. PATIENTS AND METHODS: Clinical-epidemiological retrospective cohort study that included patients diagnosed with TB with and without HIV infection between 2005-2016 in the province of Guadalajara (Spain). Epidemiological, clinical, microbiological and therapeutic variables were assessed, including microbiological resistances...
November 22, 2017: Medicina Clínica
A Martín-Lagos Maldonado, J Guilarte López-Mañas, E Borrego García, M D Vinuesa Guerrero
No abstract text is available yet for this article.
November 20, 2017: Semergen
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