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Roberto De Pietri, Alessandra Feo, José A Font, Frank Löffler, Francesco Maione, Michele Pasquali, Nikolaos Stergioulas
We present the first very long-term simulations (extending up to ∼140  ms after merger) of binary neutron star mergers with piecewise polytropic equations of state and in full general relativity. Our simulations reveal that, at a time of 30-50 ms after merger, parts of the star become convectively unstable, which triggers the excitation of inertial modes. The excited inertial modes are sustained up to several tens of milliseconds and are potentially observable by the planned third-generation gravitational-wave detectors at frequencies of a few kilohertz...
June 1, 2018: Physical Review Letters
S Mattila, M Pérez-Torres, A Efstathiou, P Mimica, M Fraser, E Kankare, A Alberdi, M Á Aloy, T Heikkilä, P G Jonker, P Lundqvist, I Martí-Vidal, W P S Meikle, C Romero-Cañizales, S J Smartt, S Tsygankov, E Varenius, A Alonso-Herrero, M Bondi, C Fransson, R Herrero-Illana, T Kangas, R Kotak, N Ramírez-Olivencia, P Väisänen, R J Beswick, D L Clements, R Greimel, J Harmanen, J Kotilainen, K Nandra, T Reynolds, S Ryder, N A Walton, K Wiik, G Östlin
Tidal disruption events (TDEs) are transient flares produced when a star is ripped apart by the gravitational field of a supermassive black hole (SMBH). We have observed a transient source in the western nucleus of the merging galaxy pair Arp 299 that radiated >1.5 × 1052 erg in the infrared and radio but was not luminous at optical or x-ray wavelengths. We interpret this as a TDE with much of its emission reradiated at infrared wavelengths by dust. Efficient reprocessing by dense gas and dust may explain the difference between theoretical predictions and observed luminosities of TDEs...
June 14, 2018: Science
Vincent A Pistritto, Joshua M Paolillo, Kathryn A Bisset, Nicholas E Leadbeater
We present an alcohol oxidation strategy to access α-trifluoromethyl ketones (TFMKs) merging catalytic oxoammonium cation oxidation with visible-light photoredox catalysis. This work uses 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl as an organic oxidant capable of generating TFMKs in good yields. The methodology serves as an improvement over previous reports of an analogous oxidation strategy requiring superstoichiometric quantities of oxidant. Both primary and secondary non-fluorinated alcohols can also be oxidised in good yields...
June 14, 2018: Organic & Biomolecular Chemistry
Jere Koskela
We introduce a low dimensional function of the site frequency spectrum that is tailor-made for distinguishing coalescent models with multiple mergers from Kingman coalescent models with population growth, and use this function to construct a hypothesis test between these model classes. The null and alternative sampling distributions of the statistic are intractable, but its low dimensionality renders them amenable to Monte Carlo estimation. We construct kernel density estimates of the sampling distributions based on simulated data, and show that the resulting hypothesis test dramatically improves on the statistical power of a current state-of-the-art method...
June 13, 2018: Statistical Applications in Genetics and Molecular Biology
Benjamin Demaree, Daniel Weisgerber, Freeman Lan, Adam R Abate
Sequencing technologies have undergone a paradigm shift from bulk to single-cell resolution in response to an evolving understanding of the role of cellular heterogeneity in biological systems. However, single-cell sequencing of large populations has been hampered by limitations in processing genomes for sequencing. In this paper, we describe a method for single-cell genome sequencing (SiC-seq) which uses droplet microfluidics to isolate, amplify, and barcode the genomes of single cells. Cell encapsulation in microgels allows the compartmentalized purification and tagmentation of DNA, while a microfluidic merger efficiently pairs each genome with a unique single-cell oligonucleotide barcode, allowing >50,000 single cells to be sequenced per run...
May 23, 2018: Journal of Visualized Experiments: JoVE
Kevin A Bird, Robert VanBuren, Joshua R Puzey, Patrick P Edger
Contents I. II. III. References SUMMARY: The merger of divergent genomes, via hybridization or allopolyploidization, frequently results in a 'genomic shock' that induces a series of rapid genetic and epigenetic modifications as a result of conflicts between parental genomes. This conflict among the subgenomes routinely leads one subgenome to become dominant over the other subgenome(s), resulting in subgenome biases in gene content and expression. Recent advances in methods to analyze hybrid and polyploid genomes with comparisons to extant parental progenitors have allowed for major strides in understanding the mechanistic basis for subgenome dominance...
June 8, 2018: New Phytologist
Robert Zorec
The focus of this special issue (SI) »Membrane Merger in Conventional and Unconventional Vesicle Secretion« is regulated exocytosis, a universally conserved mechanism, consisting of a merger between the vesicle and the plasma membranes. Although this process evolved with eukaryotic organisms some three billion years ago (Spang et al., 2015), the understanding of physiology and patobiology of this process, especially at elementary vesicle level, remains unclear. Exocytotic fusion consists of several stages, starting by vesicle delivery to the plasma membrane, initially establishing a very narrow and stable fusion pore, that can reversibly open and close several times before it can fully widen...
July 2018: Cell Calcium
María José Mellado
No abstract text is available yet for this article.
June 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
V Sawhney, E Volkova, M Shaukat, F Khan, O Segal, S Ahsan, A Chow, V Ezzat, M Finlay, P Lambiase, M Lowe, M Dhinoja, S Sporton, M J Earley, R J Hunter, R J Schilling
PURPOSE: Audit has played a key role in monitoring and improving clinical practice. However, audit often fails to drive change as summative institutional data alone may be insufficient to do so. We hypothesised that the practice of attributed audit, wherein each individual's procedural performance is presented will have a greater impact on clinical practice. This hypothesis was tested in an observational study evaluating improvement in fluoroscopy times for AF ablation. METHODS: Retrospective analyses of fluoroscopy times in AF ablations at the Barts Heart Centre (BHC) from 2012-2017...
June 1, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Mario Plebani
Laboratory services around the world are undergoing substantial consolidation and changes through mechanisms ranging from mergers, acquisitions and outsourcing, primarily based on expectations to improve efficiency, increasing volumes and reducing the cost per test. However, the relationship between volume and costs is not linear and numerous variables influence the end cost per test. In particular, the relationship between volumes and costs does not span the entire platter of clinical laboratories: high costs are associated with low volumes up to a threshold of 1 million test per year...
June 27, 2018: Diagnosis
Ya Gong, Zheng Zhang, Ya Liu, Xiu-Wen Zhou, Mian Nabeel Anwar, Ze-Shuo Li, Wei Hu, Yue-Zhong Li
The use of toxin to attack neighbours and immunity proteins to protect against toxin has been observed in bacterial conflicts, including kin discrimination. Here, we report a novel nuclease-toxin and its immunity protein function in the colony-merger incompatibility, a kind of bacterial kin discrimination, in Myxococcus xanthus DK1622. The MXAN_0049 gene was determined to be a genetic determinant for colony-merger incompatibility, and the incompatibility could be eliminated by deletion of the upstream co-transcribed MXAN_0050 gene...
May 28, 2018: Environmental Microbiology
Alike Yamuhanmode, Yilihamu Yilizati, Abulaiti Alimujiang, Yushan Maimaiaili, Yusufu Aihemaitijiang
Objective: To realize the visualization of three-dimensional microstructure of rabbit sciatic nerve bundles by micro-CT and three-dimensional visualization software Mimics17.0. Methods: The sciatic nerve tissues from 6 New Zealand rabbits were divided into 2 groups ( n =3), and the sciatic nerve tissues were stained by 1% (group A) and 5% (group B) Lugol solution respectively. After staining for 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, and 3.5 hours, the imaging changes of specimens were observed by light microscope and micro-CT...
December 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
Sai Wang, Yi-Fan Wang, Qing-Guo Huang, Tjonnie G F Li
Advanced LIGO's discovery of gravitational-wave events is stimulating extensive studies on the origin of binary black holes. Assuming that the gravitational-wave events can be explained by binary primordial black hole mergers, we utilize the upper limits on the stochastic gravitational-wave background given by Advanced LIGO as a new observational window to independently constrain the abundance of primordial black holes in dark matter. We show that Advanced LIGO's first observation run gives the best constraint on the primordial black hole abundance in the mass range 1M_{⊙}≲M_{PBH}≲100M_{⊙}, pushing the previous microlensing and dwarf galaxy dynamics constraints tighter by 1 order of magnitude...
May 11, 2018: Physical Review Letters
Q Y Liao, X Lin, S N Ye
Objective: To investigate the clinical value of video laryngoscope in localization diagnosis of upper airway obstruction in OSAHS during drug-induced sleep. Method: We searched the MEDLINE (PubMed), EMBASE, CCTR (The Cochrane Controlled Clinical Trials Register Database), CNKI, WAN FANG databases for randomized, blinded studies according Cochrane systematic review. We chose articles published between 1975 and 2016 about the value of sleep endoscopy in localization diagnosis of upper airway obstruction in OSAHS...
October 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Anne Vingaard Olesen, Rune Elvik, Camilla Sloth Andersen, Harry S Lahrmann
INTRODUCTION: Does a tow-bar increase the risk of neck injury in the struck car in a rear-end collision? The rear part of a modern car has collision zones that are rendered nonoperational when the car is equipped with a tow-bar. Past crash tests have shown that a car's acceleration was higher in a car equipped with a tow-bar and also that a dummy placed in a car with a tow-bar had higher peak acceleration in the lower neck area. METHOD: This study aimed to investigate the association between the risk of neck injury in drivers and passengers, and the presence of a registered tow-bar on the struck car in a rear-end collision...
June 2018: Journal of Safety Research
G Liu, L Chang, Y Xin, H Yang, X H Zhang, Z C Chen, Q Zhang
The clinical data of a case of Ramsay Hunt syndrome concurrent with ipsilateral Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅹ, Ⅺ cranial nerves paralysis with throat as starting place was retrospectively analyzed, and the relevant literatures were also reviewed. The case is rare, so the relevant clinical reports are less. It is important to take the objective data as well as subjective symptoms of the patients into consideration to make a definite diagnosis, so that we can treat it as soon as possible to achieve better curative effect...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Richard Menger, Brenton Pennicooke, Todd Barnes, Sarah Fouke, Phillip Kissel, Thomas Origitano, Ramin Rak, Edie Zusman, Jeffrey Cozzens, Andrew Grande, Steven Toms, Sharon Webb, Sherry Taylor
No abstract text is available yet for this article.
June 1, 2018: Neurosurgery
Johan Høy Jensen, Esben Meulengracht Flachs, Janne Skakon, Naja Hulvej Rod, Jens Peter Bonde
OBJECTIVES: We investigated work-unit exit, total and long-term sickness absence following organisational change among public healthcare employees. METHODS: The study population comprised employees from the Capital Region of Denmark (n=14 388). Data on reorganisation at the work-unit level (merger, demerger, relocation, change of management, employee layoff or budget cut) between July and December 2013 were obtained via surveys distributed to the managers of each work unit...
May 14, 2018: Occupational and Environmental Medicine
Aviva Regev, Aman Mahajan
As health care reform shifts toward value over volume, academic medical centers, known for highly specialized, high-cost care, will suffer from erosion of their traditional funding sources. Academic medical centers have undertaken mergers and partnerships with community medical centers, to maintain a more diversified, cost-effective, and competitive presence in their markets. These consolidations have seen varying results. Cultural factors are frequently cited as a cause of dysfunction and disintegration. Anesthesiology groups integrating academic and private practice physicians are likely to face many of the same challenges...
June 2018: Anesthesiology Clinics
Lionel London, Sebastian Khan, Edward Fauchon-Jones, Cecilio García, Mark Hannam, Sascha Husa, Xisco Jiménez-Forteza, Chinmay Kalaghatgi, Frank Ohme, Francesco Pannarale
Gravitational-wave observations of binary black holes currently rely on theoretical models that predict the dominant multipoles (ℓ=2,|m|=2) of the radiation during inspiral, merger, and ringdown. We introduce a simple method to include the subdominant multipoles to binary black hole gravitational waveforms, given a frequency-domain model for the dominant multipoles. The amplitude and phase of the original model are appropriately stretched and rescaled using post-Newtonian results (for the inspiral), perturbation theory (for the ringdown), and a smooth transition between the two...
April 20, 2018: Physical Review Letters
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