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https://www.readbyqxmd.com/read/28220717/merger-acquisition-and-capital-expenditure-in-health-care
#1
Wenjing Ouyang, Peter E Hilsenrath
Investment, especially through merger and acquisition (M&A), is a leading topic of concern among health care managers. In addition, the implications of this activity for organization and market concentration are of great interest to policy makers. Using a sample of 2256 firm-year observations in the health care industry during the period from 1985 to 2011, this article provides novel evidence that managers learn from financial markets in making capital expenditure (CAPEX) and M&A investment decisions. Within the industry, managers in the Drugs subsector are most likely to do so, whereas managers in the Medical Equipment and Supplies are least likely to do so...
January 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28214046/productivity-growth-case-mix-and-optimal-size-of-hospitals-a-16-year-study-of-the-norwegian-hospital-sector
#2
Kjartan Sarheim Anthun, Sverre Andreas Campbell Kittelsen, Jon Magnussen
BACKGROUND AND OBJECTIVES: This paper analyses productivity growth in the Norwegian hospital sector over a period of 16 years, 1999-2014. This period was characterized by a large ownership reform with subsequent hospital reorganizations and mergers. We describe how technological change, technical productivity, scale efficiency and the estimated optimal size of hospitals have evolved during this period. MATERIAL AND METHODS: Hospital admissions were grouped into diagnosis-related groups using a fixed-grouper logic...
January 30, 2017: Health Policy
https://www.readbyqxmd.com/read/28190508/navigating-the-clinical-trial-pathway-conception-design-execution-and-results-dissemination
#3
John S Sampalis, Joanne Watson, Stella Boukas, Marianna Boukas, Natalie Harvey, Sanjay Machado, Michel Bordeleau, Emmanouil Rampakakis
Dr Sampalis is founder, Chief Executive Officer, and Chief Scientific Officer of JSS Medical Research Inc, founded in 1997. He is a tenured professor of Surgery and Epidemiology & Biostatistics of McGill University, the University of Montreal and University of Laval. Recognized as a leading clinical epidemiologist and one of the top trauma researchers in Canada, he possesses extensive expertise in health services research, clinical trials, and offers services as a Research and Epidemiological Consultant for numerous pharmaceutical companies, hospitals and government organizations and agencies...
March 2017: Surgery
https://www.readbyqxmd.com/read/28188812/epigenetics-in-cancer-fundamentals-and-beyond
#4
REVIEW
Subhankar Biswas, C Mallikarjuna Rao
Activation of oncogenes or the deactivation of tumor suppressor genes has long been established as the fundamental mechanism leading towards carcinogenesis. Although this age old axiom is vastly accurate, thorough study over the last 15years has given us unprecedented information on the involvement of epigenetic in cancer. Various biochemical pathways that are essential towards tumorigenesis are regulated by the epigenetic phenomenons like remodeling of nucleosome by histone modifications, DNA methylation and miRNA mediated targeting of various genes...
February 8, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28167725/little-evidence-exists-to-support-the-expectation-that-providers-would-consolidate-to-enter-new-payment-models
#5
Hannah T Neprash, Michael E Chernew, J Michael McWilliams
Provider consolidation has been associated with higher health care prices and spending. The prevailing wisdom is that payment reform will accelerate consolidation, especially between physicians and hospitals and among physician groups, as providers position themselves to bear financial risk for the full continuum of patient care. Drawing on data from a number of sources from 2008 onward, we examined the relationship between Medicare's accountable care organization (ACO) programs and provider consolidation. We found that consolidation was under way in the period 2008-10, before the Affordable Care Act (ACA) established the ACO programs...
February 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28166362/organizational-change-psychosocial-work-environment-and-non-disability-early-retirement-a-prospective-study-among-senior-public-employees
#6
Nina Breinegaard, Johan Høy Jensen, Jens Peter Bonde
Objective This study examines the impact of organizational change and psychosocial work environment on non-disability early retirement among senior public service employees. Methods In January and February 2011, Danish senior public service employees aged 58-64 years (N=3254) from the Capital Region of Denmark responded to a survey assessing psychosocial work environment (ie, social capital, organizational justice, and quality of management). Work-unit organizational changes (ie, change of management, merging, demerging, and relocation) were recorded from January 2009 to March 2011...
February 6, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28160892/family-planning-american-style-redux-unintended-pregnancy-improves-barriers-remain
#7
REVIEW
Lauren Thaxton, Eve Espey
This article discusses barriers to reducing unintended pregnancy. Numerous factors may explain the high rate of unintended pregnancy in the United States, including inadequate sex education, confusing media messages about sex, cultural attitudes about sex and young parenting, conflation of contraception with abortion, inadequate health care access, burdensome contraceptive dispensing practices, and hospital merger limitations on care. Successful and promising approaches to expanding access to reproductive health care and reducing unintended pregnancy are discussed...
March 2017: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/28139966/japan-tobacco-international-to-be-the-most-successful-and-respected-tobacco-company-in-the-world
#8
Ross MacKenzie, Jappe Eckhardt, Ade Widyati Prastyani
Japan Tobacco International (JTI) is the international division of Japan Tobacco Incorporated, and the world's third largest transnational tobacco company. Founded in 1999, JTI's rapid growth has been the result of a global business strategy that potentially serves as a model for other Asian tobacco companies. This paper analyses Japan Tobacco Incorporated's global expansion since the 1980s in response to market opening, foreign competition, and declining share of a contracting domestic market. Key features of its global strategy include the on-going central role and investment by the Japanese government, and an expansion agenda based on mergers and acquisitions...
March 2017: Global Public Health
https://www.readbyqxmd.com/read/28137780/arabidopsis-hap2-gcs1-is-a-gamete-fusion-protein-homologous-to-somatic-and-viral-fusogens
#9
Clari Valansi, David Moi, Evgenia Leikina, Elena Matveev, Martín Graña, Leonid V Chernomordik, Héctor Romero, Pablo S Aguilar, Benjamin Podbilewicz
Cell-cell fusion is inherent to sexual reproduction. Loss of HAPLESS 2/GENERATIVE CELL SPECIFIC 1 (HAP2/GCS1) proteins results in gamete fusion failure in diverse organisms, but their exact role is unclear. In this study, we show that Arabidopsis thaliana HAP2/GCS1 is sufficient to promote mammalian cell-cell fusion. Hemifusion and complete fusion depend on HAP2/GCS1 presence in both fusing cells. Furthermore, expression of HAP2 on the surface of pseudotyped vesicular stomatitis virus results in homotypic virus-cell fusion...
January 30, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28131878/phospholipase-a2-potential-roles-in-native-membrane-fusion
#10
Deepti Dabral, Jens R Coorssen
Membrane fusion is a fundamental molecular mechanism by which two apposed membrane bilayers coalesce in rapid, transient steps that enable the successive merging of the outer and inner leaflets allowing lipid intermixing and subsequent mixing of the two previously separate compartments. The actual membrane merger mechanism - fusion, by definition - is conceptualized to be protein- or lipid-centric. According to the widely vetted stalk-pore hypothesis, membrane fusion proceeds via high curvature lipid intermediates...
January 25, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28121600/emboldened-the-ftc-seems-ready-to-fight-more-mergers
#11
Richard Mark Kirkner
Because hospital spending makes up the largest piece of U.S. health care spending-32%, according to data from CMS-any judicial rulings or legislative move to curb a hospital's market dominance are key to controlling overall health care costs. The FTC is stepping in.
November 2016: Managed Care
https://www.readbyqxmd.com/read/28121569/hospital-mergers-may-go-on-whoever-wins-in-november
#12
Robert Calandra
Passage of the ACA in 2010 led to some merger mania. Proponents of mergers and acquisitions say they can lower costs by creating economies of scale and smoothing the way for all kinds of clinical integration. But others say the fact that they can doesn't mean they do.
September 2016: Managed Care
https://www.readbyqxmd.com/read/28107018/structure-wettability-and-thermal-stability-of-organic-thin-films-on-gold-generated-from-the-molecular-self-assembly-of-unsymmetrical-oligo-ethylene-glycol-spiroalkanedithiols
#13
Pawilai Chinwangso, Han Ju Lee, Andrew C Jamison, Maria D Marquez, Chul Soon Park, T Randall Lee
Organic thin-films on gold were prepared from a set of new, custom-designed bidentate alkanethiols possessing a mixture of normal alkane and methoxy-terminated tri(ethylene glycol) chains. The new unsymmetrical spiroalkanedithiol adsorbates were of the form [CH3O(CH2CH2O)3(CH2)5]-[CH3(CH2)n+1]C[CH2SH]2 where n = 3 and 14; designated EG3C7-C7 and EG3C7-C18, respectively. Their corresponding self-assembled monolayers (SAMs) on gold were characterized and compared with monothiol SAMs derived from an analogous normal alkanethiol (C18SH) and an alkanethiol terminated with an oligo(ethylene glycol) (OEG) moiety (i...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28094051/competition-policy-for-health-care-provision-in-portugal
#14
Pedro Pita Barros
We review the role of competition among healthcare providers in Portugal, which has a public National Health Service (NHS) at the core of the health system. There is little competition among healthcare providers within the NHS. Competition among NHS primary care providers is hindered by excess demand (many residents in Portugal do not have a designated family doctor). Competition among NHS hospitals has been traditionally limited to cases of maximum guaranteed waiting time for surgery being exceeded. The Portuguese Competition Authority enforces competition law...
February 2017: Health Policy
https://www.readbyqxmd.com/read/28069857/market-share-matters-evidence-of-insurer-and-provider-bargaining-over-prices
#15
Eric T Roberts, Michael E Chernew, J Michael McWilliams
Proposed mergers among large US health insurers and growing consolidation among providers have renewed concerns about the effects of market concentration on commercial health care prices. Using multipayer claims for physician services provided in office settings, we estimated that-within the same provider groups-insurers with market shares of 15 percent or more (average: 24.5 percent), for example, negotiated prices for office visits that were 21 percent lower than prices negotiated by insurers with shares of less than 5 percent...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28059773/attosecond-physics-at-the-nanoscale
#16
Marcelo F Ciappina, J Perez-Hernandez, Alexandra Landsman, William Okell, Sergey Zherebtsov, Benjamin Förg, Johannes Schötz, Lennart Seiffert, Thomas Fennel, Tahir Shaaran, Tomas Zimmermann, Alexis Chacón, Roland Guichard, Amelle Zair, John Tisch, J Marangos, Tobias Witting, Avi Braun, Stefan Maier, Luis Roso, Michael Krüger, Peter Hommelhoff, Matthias Kling, Ferenc Krausz, Maciej Lewenstein
Recently two emerging areas of research, attosecond and nanoscale physics, have started to come together. Attosecond physics deals with phenomena occurring when ultrashort laser pulses, with duration on the femto- and sub-femtosecond time scales, interact with atoms, molecules or solids. The laser-induced electron dynamics occurs natively on a timescale down to a few hundred or even tens of attoseconds, which is comparable with the optical field. For comparison, the revolution of an electron on a 1s orbital of a hydrogen atom is 152 as...
January 6, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28056785/determination-of-dosage-compensation-and-comparison-of-gene-expression-in-a-triploid-hybrid-fish
#17
Li Ren, Chenchen Tang, Wuhui Li, Jialin Cui, Xingjun Tan, Yafeng Xiong, Jie Chen, Jun Wang, Jun Xiao, Yi Zhou, Jing Wang, Min Tao, Chun Zhang, Shaojun Liu
BACKGROUND: Polyploidy and hybridization are both recognized as major forces in evolution. Most of our current knowledge about differences in gene regulation in polyploid hybrids comes from plant studies. The gene expression of diverged genomes and regulatory interactions are still unclear in lower vertebrates. RESULTS: We generated 229 million cleaned reads (42.23 Gbp) from triploid of maternal grass carp (Ctenopharyngodon idellus, Cyprininae, 2n = 48) × paternal blunt snout bream (Megalobrama amblycephala, Cultrinae, 2n = 48) and their diploid parents using next-generation sequencing...
January 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28054713/alternating-terminal-electron-acceptors-at-the-basis-of-symbiogenesis-how-oxygen-ignited-eukaryotic-evolution
#18
Dave Speijer
What kind of symbiosis between archaeon and bacterium gave rise to their eventual merger at the origin of the eukaryotes? I hypothesize that conditions favouring bacterial uptake were based on exchange of intermediate carbohydrate metabolites required by recurring changes in availability and use of the two different terminal electron chain acceptors, the bacterial one being oxygen. Oxygen won, and definitive loss of the archaeal membrane potential allowed permanent establishment of the bacterial partner as the proto-mitochondrion, further metabolic integration and highly efficient ATP production...
January 5, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28039972/coupled-solitons-of-intense-high-frequency-and-low-frequency-waves-in-zakharov-type-systems
#19
Evgeny Gromov, Boris Malomed
One-parameter families of exact two-component solitary-wave solutions for interacting high-frequency (HF) and low-frequency (LF) waves are found in the framework of Zakharov-type models, which couple the nonlinear Schrödinger equation for intense HF waves to the Boussinesq (Bq) or Korteweg-de Vries (KdV) equation for the LF component through quadratic terms. The systems apply, in particular, to the interaction of surface (HF) and internal (LF) waves in stratified fluids. These solutions are two-component generalizations of the single-component Bq and KdV solitons...
December 2016: Chaos
https://www.readbyqxmd.com/read/28007837/the-impact-of-open-pollination-on-the-structural-evolutionary-dynamics-meiotic-behavior-and-fertility-of-resynthesized-allotetraploid-brassica-napus-l
#20
Mathieu Rousseau-Gueutin, Jérôme Morice, Olivier Coriton, Virginie Huteau, Gwenn Trotoux, Sylvie Nègre, Cyril Falentin, Gwennaëlle Deniot, Marie Gilet, Frédérique Eber, Alexandre Pelé, Sonia Vautrin, Joëlle Fourment, Maryse Lodé, Hélène Bergès, Anne-Marie Chèvre
Allopolyploidy, which results from the merger and duplication of two divergent genomes, has played a major role in the evolution and diversification of flowering plants. The genomic changes that occur in resynthesized or natural neopolyploids have been extensively studied, but little is known about the effects of the reproductive mode in the initial generations that may precede its successful establishment. To truly reflect the early generations of a nascent polyploid, two resynthesized allotetraploid Brassica napus populations were obtained for the first time by open pollination...
December 22, 2016: G3: Genes—Genomes—Genetics
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