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https://www.readbyqxmd.com/read/28530148/an-industry-update-what-is-new-in-the-field-of-therapeutic-delivery-this-month
#1
Elaine Harris
The present industry update covers the period 1-28 February 2017. Information was sourced primarily from company press releases, regulatory and patent agencies, scientific literature and various news websites. A report issued this month indicated that the recent American election has influenced the rate and volume of pharma acquisitions and mergers (A&M) in the final quarter of 2016 and it remains to be seen what (if any) is the effect on the therapeutic drug delivery sector in the longer term. There was positive approval news this month for Valeant, Intellipharmaceutics and Pfizer for products that offered novel therapeutic delivery...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28524673/detecting-gravitational-wave-memory-without-parent-signals
#2
Lucy O McNeill, Eric Thrane, Paul D Lasky
Gravitational-wave memory manifests as a permanent distortion of an idealized gravitational-wave detector and arises generically from energetic astrophysical events. For example, binary black hole mergers are expected to emit memory bursts a little more than an order of magnitude smaller in strain than the oscillatory parent waves. We introduce the concept of "orphan memory": gravitational-wave memory for which there is no detectable parent signal. In particular, high-frequency gravitational-wave bursts (≳kHz) produce orphan memory in the LIGO/Virgo band...
May 5, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28505544/real-life-experience-of-patients-starting-insulin-degludec-a-multicenter-analysis-of-1064-subjects-from-the-german-austrian-dpv-registry
#3
Barbara Bohn, Artur Zimmermann, Christian Wagner, Sigrun Merger, Desirée Dunstheimer, Florian Kopp, Katja Gollisch, Volker Zindel, Reinhard W Holl
BACKGROUND: The long-acting insulin analogue degludec is a therapeutic option for patients with type 1 (T1D) or type 2 diabetes (T2D). Aim of this analysis was to investigate differences in clinical characteristics of patients before and after initiating degludec use in a cohort of German/Austrian patients. METHODS: 1064 subjects with T1D/T2D and documented degludec use from the Diabetes-Patient-Follow-Up (DPV) registry were included. The follow-up cohort (n=421) comprised patients with available data before and 3-15months after switching to degludec...
May 4, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28493481/hospital-and-health-insurance-markets-concentration-and-inpatient-hospital-transaction-prices-in-the-u-s-health-care-market
#4
Seidu Dauda
OBJECTIVE: To examine the effects of hospital and insurer markets concentration on transaction prices for inpatient hospital services. DATA SOURCES: Measures of hospital and insurer markets concentration derived from American Hospital Association and HealthLeaders-InterStudy data are linked to 2005-2008 inpatient administrative data from Truven Health MarketScan Databases. STUDY DESIGN: Uses a reduced-form price equation, controlling for cost and demand shifters and accounting for possible endogeneity of market concentration using instrumental variables (IV) technique...
May 11, 2017: Health Services Research
https://www.readbyqxmd.com/read/28482766/size-does-matter-span-of-control-in-hospitals
#5
Christina Holm-Petersen, Sussanne Østergaard, Per Bo Noergaard Andersen
Purpose Centralization, mergers and cost reductions have generally led to increasing levels of span of control (SOC), and thus potentially to lower leadership capacity. The purpose of this paper is to explore how a large SOC impacts hospital staff and their leaders. Design/methodology/approach The study is based on a qualitative explorative case study of three large inpatient wards. Findings The study finds that the nursing staff and their frontline leaders experience challenges in regard to visibility and role of the leader, e...
April 10, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28474911/black-hole-spectroscopy-with-coherent-mode-stacking
#6
Huan Yang, Kent Yagi, Jonathan Blackman, Luis Lehner, Vasileios Paschalidis, Frans Pretorius, Nicolás Yunes
The measurement of multiple ringdown modes in gravitational waves from binary black hole mergers will allow for testing the fundamental properties of black holes in general relativity and to constrain modified theories of gravity. To enhance the ability of Advanced LIGO/Virgo to perform such tasks, we propose a coherent mode stacking method to search for a chosen target mode within a collection of multiple merger events. We first rescale each signal so that the target mode in each of them has the same frequency and then sum the waveforms constructively...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28459815/the-improved-business-valuation-model-for-rfid-company-based-on-the-community-mining-method
#7
Shugang Li, Zhaoxu Yu
Nowadays, the appetite for the investment and mergers and acquisitions (M&A) activity in RFID companies is growing rapidly. Although the huge number of papers have addressed the topic of business valuation models based on statistical methods or neural network methods, only a few are dedicated to constructing a general framework for business valuation that improves the performance with network graph (NG) and the corresponding community mining (CM) method. In this study, an NG based business valuation model is proposed, where real options approach (ROA) integrating CM method is designed to predict the company's net profit as well as estimate the company value...
2017: PloS One
https://www.readbyqxmd.com/read/28457949/%C3%A3-ngstrom-size-exocytotic-fusion-pore-implications-for-pituitary-hormone-secretion
#8
REVIEW
Marko Kreft, Jernej Jorgačevski, Matjaž Stenovec, Robert Zorec
In the past, vesicle content release was thought to occur immediately and completely after triggering of exocytosis. However, vesicles may merge with the plasma membrane to form an Ångstrom diameter fusion pore that prevents the exit of secretions from the vesicle lumen. The advantage of such a narrow pore is to minimize the delay between the trigger and the release. Instead of stimulating a sequence of processes, leading to vesicle merger with the plasma membrane and a formation of a fusion pore, the stimulus only widens the pre-established fusion pore...
April 27, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28453513/genetic-diversity-and-population-structure-of-the-tsetse-fly-glossina-fuscipes-fuscipes-diptera-glossinidae-in-northern-uganda-implications-for-vector-control
#9
Robert Opiro, Norah P Saarman, Richard Echodu, Elizabeth A Opiyo, Kirstin Dion, Alexis Halyard, Augustine W Dunn, Serap Aksoy, Adalgisa Caccone
Uganda is the only country where the chronic and acute forms of human African Trypanosomiasis (HAT) or sleeping sickness both occur and are separated by < 100 km in areas north of Lake Kyoga. In Uganda, Glossina fuscipes fuscipes is the main vector of the Trypanosoma parasites responsible for these diseases as well for the animal African Trypanosomiasis (AAT), or Nagana. We used highly polymorphic microsatellite loci and a mitochondrial DNA (mtDNA) marker to provide fine scale spatial resolution of genetic structure of G...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28452538/digging-deeper-observing-primordial-gravitational-waves-below-the-binary-black-hole-produced-stochastic-background
#10
T Regimbau, M Evans, N Christensen, E Katsavounidis, B Sathyaprakash, S Vitale
The merger rate of black hole binaries inferred from the detections in the first Advanced LIGO science run implies that a stochastic background produced by a cosmological population of mergers will likely mask the primordial gravitational wave background. Here we demonstrate that the next generation of ground-based detectors, such as the Einstein Telescope and Cosmic Explorer, will be able to observe binary black hole mergers throughout the Universe with sufficient efficiency that the confusion background can potentially be subtracted to observe the primordial background at the level of Ω_{GW}≃10^{-13} after 5 years of observation...
April 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28452509/forecasting-tidal-disruption-events-for-binary-black-holes-with-an-outer-tertiary
#11
Naoki Seto, Koutarou Kyutoku
We discuss the gravitational wave (GW) emission and the orbital evolution of a hierarchical triple system composed of an inner binary black hole (BBH) and an outer tertiary. Depending on the kick velocity at the merger, the merged BBH could tidally disrupt the tertiary. Even though the fraction of BBH mergers accompanied by such disruptions is expected to be much smaller than unity, the existence of a tertiary and its basic parameters (e.g., semimajor axis, projected mass) can be examined for more than 10^{3} BBHs with the follow-on missions to the space GW detector LISA...
April 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28451301/room-temperature-decarboxylative-cyanation-of-carboxylic-acids-using-photoredox-catalysis-and-cyanobenziodoxolones-a-divergent-mechanism-compared-to-alkynylation
#12
Franck Le Vaillant, Matthew D Wodrich, Jérôme Waser
The one-step conversion of aliphatic carboxylic acids to the corresponding nitriles has been accomplished via the merger of visible light mediated photoredox and cyanobenziodoxolones (CBX) reagents. The reaction proceeded in high yields with natural and non-natural α-amino and α-oxy acids, affording a broad scope of nitriles with excellent tolerance of the substituents in the α position. The direct cyanation of dipeptides and drug precursors was also achieved. The mechanism of the decarboxylative cyanation was investigated both computationally and experimentally and compared with the previously developed alkynylation reaction...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28432523/hypothesis-free-analyses-from-a-large-psoriatic-arthritis-cohort-support-merger-to-consolidated-peripheral-arthritis-definition-without-subtyping
#13
Daniel Stekhoven, Almut Scherer, Michael J Nissen, Véronique Grobéty, Nikhil Yawalkar, Peter M Villiger, Burkhard Möller
Current ClASsification criteria for Psoriatic ARthritis classification criteria for psoriatic arthritis (PsA) provide a preliminary definition of inflammatory articular disease. This study aimed to further characterize PsA peripheral arthritis using purely data-driven approaches for the affected joint distribution pattern. PsA patients from the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) database were clustered according to similarities in 66 swollen and in 68 tender joints. Clusters were compared in terms of other disease characteristics and studied for coincidence with traditional PsA subtypes, stability over time and treatment response upon first tumour necrosis factor alpha (TNF-α) therapy...
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28425692/antitrust-law-hospital-mergers-third-circuit-clarifies-geographic-market-definition-and-raises-bar-for-efficiencies-defense
#14
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Harvard Law Review
https://www.readbyqxmd.com/read/28423282/good-riddance-to-big-insurance-mergers
#15
Leemore S Dafny
Eighteen months after four of the five largest U.S. health insurers announced multibillion-dollar merger deals, federal judges, siding with the Department of Justice (DOJ), have issued preliminary injunctions halting the two transactions. These decisions will cost the insurers: they spent over $2..
May 11, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28418185/cu-pd-synergistic-dual-catalysis-asymmetric-%C3%AE-allylation-of-an-%C3%AE-cf3-amide
#16
Akira Saito, Naoya Kumagai, Masakatsu Shibasaki
Despite the burgeoning demand for fluorine-containing chemical entities, the construction of CF3 -containing stereogenic centers has remained elusive. Herein, we report the strategic merger of Cu(I) /base-catalyzed enolization of an α-CF3 amide and Pd(0) -catalyzed allylic alkylation in an enantioselective manner to deliver chiral building blocks bearing a stereogenic carbon center connected to a CF3 , an amide carbonyl, and a manipulable allylic group. The phosphine complexes of Cu(I) and Pd(0) engage in distinct catalytic roles without ligand scrambling to render the dual catalysis operative to achieve asymmetric α-allylation of the amide...
May 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28409933/benzene-c-h-etherification-via-photocatalytic-hydrogen-evolution-cross-coupling-reaction
#17
Yi-Wen Zheng, Pan Ye, Bin Chen, Qing-Yuan Meng, Ke Feng, Wenguang Wang, Li-Zhu Wu, Chen-Ho Tung
Aryl ethers can be constructed from the direct coupling between the benzene C-H bond and the alcohol O-H bond with the evolution of hydrogen via the synergistic merger of photocatalysis and cobalt catalysis. Utilizing the dual catalyst system consisting of 3-cyano-1-methylquinolinum photocatalyst and cobaloxime, intermolecular etherification of arenes with various alcohols and intramolecular alkoxylation of 3-phenylpropanols with formation of chromanes are accomplished. These reactions proceed at remarkably mild conditions, and the sole byproduct is equivalent hydrogen gas...
May 5, 2017: Organic Letters
https://www.readbyqxmd.com/read/28408922/a-novel-histogram-region-merging-based-multithreshold-segmentation-algorithm-for-mr-brain-images
#18
Siyan Liu, Xuanjing Shen, Yuncong Feng, Haipeng Chen
Multithreshold segmentation algorithm is time-consuming, and the time complexity will increase exponentially with the increase of thresholds. In order to reduce the time complexity, a novel multithreshold segmentation algorithm is proposed in this paper. First, all gray levels are used as thresholds, so the histogram of the original image is divided into 256 small regions, and each region corresponds to one gray level. Then, two adjacent regions are merged in each iteration by a new designed scheme, and a threshold is removed each time...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/28408315/the-corr-hypothesis-for-genes-in-organelles
#19
John F Allen
Chloroplasts and mitochondria perform energy transduction in photosynthesis and respiration. These processes can be described in physico-chemical terms with no obvious requirement for co-located genetic systems, separat from those of the rest of the cell. Accordingly, biochemists once tended to regard endosymbiosis as untestable evolutionary speculation. Lynn Sagan's seminal 1967 paper "On the Origin of Mitosing Cells" outlined the evolution of eukaryotic cells by endosymbiosis of prokaryotes. The endosymbiont hypothesis is consistent with presence of DNA in chloroplasts and mitochondria, but does not assign it a function...
April 11, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28407809/merger-of-two-dispatch-centres-does-it-improve-quality-and-patient-safety
#20
Alexandre Moser, Annette Mettler, Vincent Fuchs, Walter Hanhart, Claude-François Robert, Vincent Della Santa, Fabrice Dami
BACKGROUND: Dispatch centres (DCs) are considered an essential but expensive component of many highly developed healthcare systems. The number of DCs in a country, region, or state is usually based on local history and often related to highly decentralised healthcare systems. Today, current technology (Global Positioning System or Internet access) abolishes the need for closeness between DCs and the population. Switzerland went from 22 DCs in 2006 to 17 today. This study describes from a quality and patient safety point of view the merger of two DCs...
April 13, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
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