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Africa. Nigeria. Lagos.

O O Adelowo, B H Olaosebikan, B A Animashaun, R O Akintayo
Juvenile systemic lupus erythematosus (JSLE) is a complex multisystemic autoimmune disorder of unknown cause. It accounts for about one in five cases of SLE. The tendency for SLE to run a fulminant course when it starts in childhood has made JSLE a potentially more severe disease than adult SLE. Reports of JSLE from sub-Saharan Africa are scanty in spite of the increasing reports of adult SLE. We conducted a 4-year retrospective study of JSLE cases seen at the Lagos State University Teaching Hospital between January 2010 and December 2014...
October 21, 2016: Lupus
Barakat Adeola Animasahun, Akpoembele D Madise-Wobo, Bode A Falase, Samuel I Omokhodion
BACKGROUND: There are only very few reports on Fallot's tetralogy in Africa especially from sub-Saharan Africa. At best tetralogy of Fallot (TOF) is only mentioned as part of reports of surveys of other congenital heart diseases or as case reports in the region. There has been no report on cohorts of children with TOF in West Africa. This article describes the pattern and presentation of children diagnosed with TOF patients in a tertiary hospital in sub-Saharan Africa over a 9-year period...
October 2016: Cardiovascular Diagnosis and Therapy
Akunnaya P Opoko, Adedapo A Oluwatayo
Lagos is one of the fastest growing cities in Africa, which is grappling with the challenges of poorly managed urbanisation. With an estimated population of about 17.5 million, solid waste management is one of the most pressing environmental challenges currently faced in the city. It is estimated that more than 9071847.4kg of urban waste is generated every day in the city. The city lacks the capacity to deal with such magnitude of waste. Consequently, the city has involved the private sector (private sector participation) in its waste management drive...
September 23, 2016: Waste Management & Research
Chima Ohuabunwo, Celestine Ameh, Oyin Oduyebo, Anthony Ahumibe, Bamidele Mutiu, Adebola Olayinka, Wasiu Gbadamosi, Erika Garcia, Carolina Nanclares, Wale Famiyesin, Abdulaziz Mohammed, Patrick Nguku, Richard I Koko, Joshua Obasanya, Durojaye Adebayo, Yemi Gbadegesin, Oni Idigbe, Olukayode Oguntimehin, Sara Nyanti, Charles Nzuki, Ismail Abdus-Salam, Joseph Adeyemi, Nnanna Onyekwere, Emmanuel Musa, David Brett-Major, Faisal Shuaib, Abdulsalami Nasidi
INTRODUCTION: Nigeria's Ebola virus disease (EVD) outbreak began when an infected diplomat from Liberia arrived Lagos, Africa's most populous city with subsequent transmission to another large city. METHODS: First, second and third generation contacts were traced, monitored, and classified. Symptomatic contacts were managed at Ebola treatment centers as suspected, probable and confirmed EVD-cases using standard operating procedures adapted from WHO EVD-guidelines...
August 26, 2016: International Journal of Infectious Diseases: IJID
Luther Agbonyegbeni Agaga, Theresa Adebola John
In Nigeria, medical students are trained in more didactic environments than their counterparts in researchintensive academic medical centers. Their conception of pharmacology was thus sought. Students who are taking/have takenthe medical pharmacology course completed an 18-question survey within 10min by marking one/more choices fromalternatives. Instructions were: "Dear Participant, Please treat as confidential, give your true view, avoid influences, avoidcrosstalk, return survey promptly." Out of 301 students, 188 (62...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
Chioma C Obi, Sunday A Adebusoye, Esther O Ugoji, Mathew O Ilori, Olukayode O Amund, William J Hickey
Estuarine sediments are significant repositories of anthropogenic contaminants, and thus knowledge of the impacts of pollution upon microbial communities in these environments is important to understand potential effects on estuaries as a whole. The Lagos lagoon (Nigeria) is one of Africa's largest estuarine ecosystems, and is impacted by hydrocarbon pollutants and other industrial and municipal wastes. The goal of this study was to elucidate microbial community structure in Lagos lagoon sediments to identify groups that may be adversely affected by pollution, and those that may serve as degraders of environmental contaminants, especially polycyclic aromatic hydrocarbons (PAHs)...
2016: Frontiers in Microbiology
Richard A Heipertz, Ojor Ayemoba, Eric Sanders-Buell, Kultida Poltavee, Phuc Pham, Gustavo H Kijak, Esther Lei, Meera Bose, Shana Howell, Anne Marie OʼSullivan, Adam Bates, Taylor Cervenka, Janelle Kuroiwa, Akindiran Akintunde, Onyekachukwu Ibezim, Abraham Alabi, Obumneke Okoye, Mark Manak, Jennifer Malia, Sheila Peel, Mohammed Maisaka, Darrell Singer, Robert J O'Connell, Merlin L Robb, Jerome H Kim, Nelson L Michael, Ogbonnaya Njoku, Sodsai Tovanabutra
While abundant sequence information is available from human immunodeficiency virus type 1 (HIV-1) subtypes A, B, C and CRF01_AE for HIV-1 vaccine design, sequences from West Africa are less represented. We sought to augment our understanding of HIV-1 variants circulating in 6 Nigerian cities as a step to subsequent HIV-1 vaccine development.The G/CRF02_AG multi-region hybridization assay (MHA) was developed to differentiate subtype G, CRF02_AG and their recombinants from other subtypes based on 7 HIV-1 segments...
August 2016: Medicine (Baltimore)
Rita O Oladele, Alani S Akanmu, Augustina O Nwosu, Folasade T Ogunsola, Malcolm D Richardson, David W Denning
Background.  Cryptococcal meningitis has a high mortality in human immunodeficiency virus (HIV)-infected persons in Africa. This is preventable with early screening and preemptive therapy. We evaluated the prevalence of cryptococcal disease by antigen testing, possible associated factors, and outcomes in HIV-infected patients being managed in a tertiary hospital in Lagos, Nigeria. Methods.  Sera were collected from 214 consenting HIV-infected participants with CD4(+) counts <250 cells/mm(3), irrespective of their antiretroviral therapy (ART) status, between November 2014 and May 2015...
March 2016: Open Forum Infectious Diseases
Muideen O Bakare, Mashudat A Bello-Mojeed, Kerim M Munir, Oluwayemi C Ogun, Julian Eaton
Late diagnosis and interventions characterize childhood neurodevelopmental disorders in Sub-Saharan Africa. This has negatively impacted on the prognosis of the children with neurodevelopmental disorders. This study examined the prevalence and pattern of neurodevelopmental delays among children under the age of 3 years attending immunization clinics in Lagos State, Nigeria and also affords opportunity of early follow-up and interventions, which had been documented to improve prognosis. The study involved two stage assessments; which consisted of first phase screening of the children for neurodevelopmental delays in immunization clinics at primary healthcare centers Lagos State, Nigeria and second phase which consists of definitive clinical evaluation and follow-up interventions for children screened positive for neurodevelopmental delays...
2016: Scientific Reports
Oyetunde Timothy Salawu, Chelsea Ndidi Esume
BACKGROUND: The interaction between HIV and Trichomonas vaginalis infection has been widely studied in most developed countries but with scanty information in sub-Saharan Africa. While many of these studies have examined the prevalence of T. vaginalis infection in HIV positive individuals, no study in Nigeria has shown the effect of T. vaginalis on HIV transmission. Therefore, the study aimed to determine the occurrence of HIV in T. vaginalis infected women. METHODS: A descriptive study was conducted among women attending STI clinic at the General Hospital, Badagry, Lagos, Nigeria...
January 2016: Journal of Reproduction & Infertility
Tunji Oluleye
No abstract text is available yet for this article.
May 2016: European Journal of Ophthalmology
Julie C Bowker, Adesola Adebusola Ojo, Matthew H Bowker
The study of social withdrawal subtypes is no longer limited to Western societies but has extended to non-Western countries, such as China. This study considers, for the first time, social withdrawal subtypes in an African country (Nigeria) by examining emerging adults' (N = 151; 54% female; Mage = 19.92 years, SD = 2.54) perceptions, attitudes, and responses to shy, unsociable, and socially competent behaviors. Results revealed that Nigerian emerging adults perceived significant differences between shy, unsociable, and socially competent behavior in several ways incommensurate with participants of previous studies conducted in North America, Europe, and China...
February 2016: Journal of Adolescence
Barakat Adeola Animasahun, Akpoembele Deborah Madise-Wobo, Samuel I Omokhodion, Olisamedua Fidelis Njokanma
INTRODUCTION: There is a dearth of literature on tetralogy of fallot (TOF) in children in Sub-Saharan Africa. This study up aims to describe the prevalence, clinical profile and associated cardiac anomaly of children diagnosed with TOF documented over an eight year period in a tertiary hospital in South Western Nigeria. METHODS: A prospective review of all consecutive cases of TOF diagnosed with echocardiography at the Lagos State University Teaching Hospital (LASUTH) between January 2007 and December 2014...
2015: Journal of Cardiovascular and Thoracic Research
Yoon-Mi Hur
Assortative mating for educational level is a widespread phenomenon in Western industrialized societies. However, whether or not the results from Western samples can be generalizable to populations in developing countries in Africa remains to be seen. The present study investigated assortative mating for educational level in parents of public school children (N > 7000) in the Lagos State in Nigeria. Approximately 61.5 % of the parents had spouses at the same level of education. More mothers than fathers married upward in educational level...
July 2016: Behavior Genetics
Azeez Butali, Peter Mossey, Nikki Tiffin, Wasiu Adeyemo, Mekonen Eshete, Chrispinanus Mumena, Rosemary Audu, Chika Onwuamah, Pius Agbenorku, Mobolanle Ogunlewe, Adetokunbo Adebola, Hecto Olasoji, Babatunde Aregbesola, Ramat Braimah, Abimibola Oladugba, Ifeanyichukwu Onah, Ezekiel Adebiyi, Peter Olaitan, Lukman Abdur-Rahman, Adebowale Adeyemo
This article is an outcome of the African Craniofacial Anomalies Research Network (AfriCRAN) Human Hereditary and Health (H3A) grant planning meeting in 2012 in Lagos, Nigeria. It describes the strengths of a multidisciplinary team approach to solving complex genetic traits in the craniofacial region. It also highlights the different components and argues for the composition of similar teams to fast track the discovery of disease genes, diagnostic tools, improved clinical treatment and ultimately prevention of diseases...
2015: Pan African Medical Journal
Vincent Boima, Adebowale Dele Ademola, Aina Olufemi Odusola, Francis Agyekum, Chibuike Eze Nwafor, Helen Cole, Babatunde L Salako, Gbenga Ogedegbe, Bamidele O Tayo
Background. Blood pressure (BP) control is poor among hypertensives in many parts of sub-Saharan Africa. A potentially modifiable factor for control of BP is medication nonadherence (MNA); our study therefore aimed to determine factors associated with MNA among hypertensives in Ghana and Nigeria. Methodology. We conducted a multicenter cross-sectional study. Patients were recruited from Korle-Bu Hospital (n = 120), Ghana; and University of Port Harcourt Teaching Hospital, (n = 73) Apapa General Hospital Lagos (n = 79) and University College Hospital Ibadan (n = 85), Nigeria...
2015: International Journal of Hypertension
Innocent A O Uah, Oliver C Ezechi, Aigbe Gregory Ohihoin
The HIV negative partner in a HIV serodiscordant relationship is at high risk of becoming HIV infected. The annual risk of HIV infection for a partner of a person with HIV is about 10%, with higher annual transmission rates of 20-25% per year reported in Rwanda and Zambia. Although there is considerable variation across countries, recent studies in southern and east Africa countries with mature epidemics reported that up to two-thirds of infected persons in stable relationship are discordant. HIV serodiscordance is thus a recognized priority for HIV prevention intervention...
June 2015: African Journal of Reproductive Health
Tunji S Oluleye, Adekunle Rotimi-Samuel, Adetunji Adenekan
PURPOSE: Retinopathy of prematurity (ROP), thought to be rare in Nigeria, sub-Saharan Africa, has been reported in recent studies. Developing cost-effective screening is crucial for detecting retinal changes amenable to treatment. This study describes the use of an iPhone combined with a 20-D lens in screening for ROP in Lagos, Nigeria. METHODS: The ROP screening program was approved by the Lagos University Teaching Hospital Ethical Committee. Preterm infants with birthweight of less than 1...
January 2016: European Journal of Ophthalmology
Olayemi O Ayepola, Nurudeen A Olasupo, Louis O Egwari, Karsten Becker, Frieder Schaumburg
Few reports from Africa suggest that resistance pattern, virulence factors and genotypes differ between Staphylococcus aureus from nasal carriage and clinical infection. We therefore compared antimicrobial resistance, selected virulence factors and genotypes of S. aureus from nasal carriage and clinical infection in Southwest Nigeria. Non-duplicate S. aureus isolates were obtained from infection (n = 217) and asymptomatic carriers (n = 73) during a cross sectional study in Lagos and Ogun States, Nigeria from 2010-2011...
2015: PloS One
T V Dougnon, H S Bankole, Y M G Hounmanou, S Echebiri, P Atchade, J Mohammed
Malaria is a major disease in Africa and leads to various public health problems. A study was carried out at the Aviation Medical Clinic Laboratory, Murtala Mohammed Airport, Ikeja, Lagos State, Nigeria, in 2014. The work aimed to determine the prevalence of malaria among patients attending the laboratory. Blood samples were therefore collected from 51 patients and subjected to both blood smear microscopy and a rapid immunochromatographic diagnostic test (SD BIOLINE Malaria Ag) for detection of, respectively, malaria parasites and antigens...
2015: Journal of Parasitology Research
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