keyword
MENU ▼
Read by QxMD icon Read
search

agtr1

keyword
https://www.readbyqxmd.com/read/29701105/a-prospective-study-of-the-impact-of-agtr1-a1166c-on-the-effects-of-candesartan-in-patients-with-heart-failure
#1
Simon de Denus, Marie-Pierre Dubé, René Fouodjio, Thao Huynh, Marie-Hélène LeBlanc, Serge Lepage, Richard Sheppard, Nadia Giannetti, Joël Lavoie, Asmaa Mansour, Sylvie Provost, Valérie Normand, Ian Mongrain, Mathieu Langlois, Eileen O'Meara, Anique Ducharme, Normand Racine, Marie-Claude Guertin, Jacques Turgeon, Michael S Phillips, Jean-Lucien Rouleau, Jean-Claude Tardif, Michel White
AIM: To evaluate the impact of AGTR1 A1166C (rs5186) on the response to candesartan in patients with heart failure. MATERIALS & METHODS: Prospective, multicentre, open-label study. We studied 299 symptomatic patients with heart failure presenting a left ventricular ejection fraction ≤40%. RESULTS: Reductions in the primary end points of natriuretic peptides were not significantly associated with AGTR1 A1166C. Nevertheless, carrying the 1166C allele was associated with a greater compensatory increase in renin activity (p = 0...
April 27, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29627490/genetically-determined-enlargement-of-carotid-body-evaluated-using-computed-angiotomography
#2
Przemysław Jaźwiec, Paweł Gać, Monika Chaszczewska-Markowska, Katarzyna Bogunia-Kubik, Grzegorz Mazur, Rafał Poręba
It has recently been established that carotid bodies play a significant role in the regulation of activities of the cardiovascular system as well as in the pathogenesis of arterial hypertension, heart failure and diabetes. Aim of study was to determinate the influence of polymorphisms within genes of the renin-angiotensin-aldosterone system (RAAS) on the volume of the carotid bodies (CB) in patients with hypertension (HTA). The study group consisted of 77 patients with HTA. All patients were genotyped for single-nucleotide polymorphisms of genes coding for: angiotensinogen: rs4762, rs5049, rs5051 and rs699; angiotensin-converting enzyme: rs4343; angiotensin receptor type 1 gene (AGTR1): rs5182 and rs5186; and the aldosterone synthase: rs1799998...
April 5, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29626523/expression-of-genes-in-primo-vasculature-floating-in-lymphatic-endothelium-under-lipopolysaccharide-and-acupuncture-electric-stimulation
#3
Jun-Young Shin, Jong-Ok Ji, Da-Woon Choi, Sang-Heon Choi, Jong-Gu Choi, Min-Suk Rho, Ji Yoon Lee, Sang-Suk Lee
It is known that the existence of primo vascular system (PVS) including the primo nodes and vessels. However, it is poorly understood the relevant genes in the PVS system both patho- and physiologic condition. Here, we first examined the gene expression in primo vessels (PV) floating in lymphatic endothelium by isolation of PVS and lymphatic vessels (LV) containing PVS. To investigate therapeutic effects, both PV and LV containing PVS were isolated after lipopolysaccharides (LPS) injection and acupuncture electric stimulation (AES) at two acupoints of Joksamni (ST36) and Hapgok (LI04) following LPS...
April 4, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29602923/-the-role-of-genes-of-renin-angiotensin-system-in-the-development-of-adverse-outcomes-of-treatment-in-severe-intraventricular-hemorrhages-in-premature-infants
#4
Наталия И Гасюк, Наталия С Артемова, Елена М Ковалева, Валерий И Похилько, Галина А Соловьева
OBJECTIVE: Introduction: Intraventricular hemorrhage (IVH) causes increased morbidity and mortality in premature infants and is associated with adverse neurological outcomes. The aim of the research is to confirm the role of genes of renin-angiotensin system in the development of adverse outcomes of treatment of severe IVC in preterm. PATIENTS AND METHODS: Materials and methods: A prospective study was conducted, which included 58 premature infants (average birth weight 1016...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29593124/association-between-3-utr-polymorphisms-in-genes-acvr2a-agtr1-and-rgs2-and-preeclampsia
#5
Andrea Mendelova, Veronika Holubekova, Marian Grendar, Pavol Zubor, Iveta Svecova, Dusan Loderer, Zuzana Snahnicanova, Kamil Biringer, Jan Danko, Zora Lasabova
Preeclampsia (PE) is a pregnancy specific disease with several risk factors such as genetic polymorphisms, environmental and social factors participating in its development. The aim of this study was to investigate whether distribution of three putative regulatory SNPs rs13430086, rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2, respectively, that have been associated with hypertension and regulation of trophoblast invasion differ between women with PE and control group. The associations of rs13430086, rs5186 and rs4606 with preeclampsia were tested in two groups - the group of 50 women with PE and the control group of 42 healthy pregnant women at term...
March 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29581855/association-between-angiotensin-ii-receptor-type-1-a1166c-polymorphism-and-chronic-kidney-disease
#6
Hsien-Feng Chang, Po-Jen Hsiao, Yu-Juei Hsu, Fu-Huang Lin, Chin Lin, Wen Su, Hsiang-Cheng Chen, Sui-Lung Su
Studies of the association between angiotensin II receptor type 1 A1166C (AGTR1 A1166C) polymorphism and chronic kidney disease (CKD) risk have yielded conflicting results. We conducted a combined case-control study and meta-analysis to better define this association. The case-control study included 634 end-stage renal disease (ESRD) patients and 739 healthy controls. AGTR1 A1166C genotype was determined using polymerase chain reaction and iPLEX Gold SNP genotyping methods. The meta-analysis included 24 studies found in the PubMed and Cochrane Library databases...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29550391/antidepressant-like-effect-of-losartan-involves-trkb-transactivation-from-angiotensin-receptor-type-2-agtr2-and-recruitment-of-fyn
#7
Cassiano R A F Diniz, Plinio C Casarotto, Senem M Fred, Caroline Biojone, Eero Castrén, Sâmia R L Joca
The renin-angiotensin system (RAS) is associated with peripheral fluid homeostasis and cardiovascular function, but recent evidence also suggests a functional role in the brain. RAS regulates physiological and behavioral parameters related to the stress response, including depressive symptoms. Apparently, RAS can modulate levels of brain-derived neurotrophic factor (BDNF) and TRKB, which are important in the neurobiology of depression and antidepressant action. However, the interaction between the BDNF/TRKB system and RAS in depression has not been investigated before...
March 14, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29482191/post-transcriptional-control-of-angiotensin-ii-type-1-receptor-regulates-osteosarcoma-cell-death
#8
Yue Zhao, Kaicheng Xu, Peng Liu
BACKGROUND/AIMS: MicroRNAs (miRNAs) play an essential role in the tumorigenesis of osteosarcoma (OS). However, the effects of miR-1248 on chemo-resistant potential of OS have not been studied. Here, we addressed this question. METHODS: The levels of miR-1248 and apoptotic protein angiotensin II type 1 receptor (AGTR1) in OS specimens were examined by RT-qPCR and Western blotting, respectively. The relationship between miR-1248 and AGTR1 was determined by analysis of Spearman's Rank Correlation Coefficients...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29413755/association-of-agtr1-a1166c-and-ace-i-d-polymorphisms-with-breast-cancer-risk-in-north-indian-population
#9
Anukriti Singh, Nidhi Srivastava, Sonal Amit, S N Prasad, M P Misra, Bushra Ateeq
Renin angiotensin system (RAS) comprising Angiotensin converting enzyme (ACE), Angiotensin II (Ang II) and its receptor Angiotensin II receptor type I (AGTR1), plays a critical role in several diseases including cancer. A single nucleotide polymorphism (SNP) A1166C located in 3' untranslated region (UTR) of AGTR1 and an insertion/deletion (I/D) polymorphism present in intron 16 of ACE gene have been associated with many diseases, but their association with Breast cancer (BCa) is still debatable. Here, we for the first time investigated the association of these polymorphisms in a North Indian BCa cohort including 161 patients and 152 healthy women...
April 2018: Translational Oncology
https://www.readbyqxmd.com/read/29371888/identification-of-genomic-copy-number-variations-associated-with-specific-clinical-features-of-head-and-neck-cancer
#10
Boris Zagradišnik, Danijela Krgović, Špela Stangler Herodež, Andreja Zagorac, Bogdan Ćižmarević, Nadja Kokalj Vokač
Background: Copy number variations (CNSs) of large genomic regions are an important mechanism implicated in the development of head and neck cancer, however, for most changes their exact role is not well understood. The aim of this study was to find possible associations between gains/losses of genomic regions and clinically distinct subgroups of head and neck cancer patients. Results: Array comparative genomic hybridization (aCGH) analysis was performed on DNA samples in 64 patients with cancer in oral cavity, oropharynx or hypopharynx...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29365981/severity-of-cardiovascular-remodeling-in-comorbidity-of-essential-hypertension-and-type-2-diabetes-depending-on-genetic-polymorphism-of-agtr1-and-irs-1
#11
Anna Shalimova, O Bilovol, L Bobronnikova
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29260398/integrated-bioinformatics-analysis-of-potential-biomarkers-for-prostate-cancer
#12
Jiufeng Tan, Xuefei Jin, Kaichen Wang
The aim was to expound the pathogenesis of prostate cancer and to identify the potentially biomarkers for prostate cancer (PC). DNA methylation microarray data GSE38240 containing 8 prostate cancer metastases and 4 normal prostate samples as well as gene expression profile data GSE26910 containing 6 prostate primary tumors and 6 normal samples were used. Differentially expressed genes (DEGs) and differently methylated sites of PC were screened and the regulatory network was constructed with DEGs-related transcription factors (TFs)...
December 19, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29259013/the-carma3-bcl10-malt1-signalosome-drives-nf-%C3%AE%C2%BAb-activation-and-promotes-aggressiveness-in-angiotensin-ii-receptor-positive-breast-cancer
#13
Prasanna Ekambaram, Jia-Ying Lloyd Lee, Nathaniel E Hubel, Dong Hu, Saigopalakrishna Yerneni, Phil G Campbell, Netanya Pollock, Linda R Klei, Vincent J Concel, Phillip C Delekta, Arul M Chinnaiyan, Scott A Tomlins, Daniel R Rhodes, Nolan Priedigkeit, Adrian V Lee, Steffi Oesterreich, Linda McAllister-Lucas, Peter C Lucas
The angiotensin II receptor AGTR1, which mediates vasoconstrictive and inflammatory signaling in vascular disease, is overexpressed aberrantly in some breast cancers. In this study, we established the significance of an AGTR1-responsive NF-κB signaling pathway in this breast cancer subset. We documented that AGTR1 overexpression occurred in the luminal A and B subtypes of breast cancer, was mutually exclusive of HER2 expression, and correlated with aggressive features that include increased lymph node metastasis, reduced responsiveness to neoadjuvant therapy, and reduced overall survival...
December 19, 2017: Cancer Research
https://www.readbyqxmd.com/read/29250329/effect-of-agtr1-and-bdkrb2-gene-polymorphisms-on-atorvastatin-metabolism-in-a-mexican-population
#14
Sarahí Herrera-González, Denisse Aideé Martínez-Treviño, Marcelino Aguirre-Garza, Magdalena Gómez-Silva, Hugo Alberto Barrera-Saldaña, Rafael Baltazar Reyes León-Cachón
Discrepancies in the response to drugs are partially due to polymorphisms in genes involved in drug metabolism and transport. The frequency, pattern and impact of these polymorphisms vary among populations. In the present study, the pharmacokinetics and pharmacogenetics of atorvastatin (ATV) in a Mexican population were investigated. The study cohort exhibited differing ATV metabolizing phenotypes, and in subsequent allelic discrimination assays, single nucleotide polymorphisms in the angiotensinogen, angiotensin II type 1 receptor ( AGTR1 ) and bradykinin B2 receptor ( BDKRB2 ) genes were genotyped and their effects on the pharmacokinetic parameters of ATV were assessed...
December 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29192236/estrogen-attenuates-agtr1-expression-to-reduce-pancreatic-%C3%AE-cell-death-from-high-glucose
#15
Suwattanee Kooptiwut, Keerati Wanchai, Namoiy Semprasert, Chatchawan Srisawat, Pa-Thai Yenchitsomanus
Chronic exposure of pancreatic β-cells to high glucose levels results in β-cell dysfunction and death. These effects can be protected by estrogen. The local pancreatic renin-angiotensin system (RAS) has been shown as a novel pathological pathway of high-glucose-induced cell death. The effect of estrogen on pancreatic RAS is still unknown. This study examines whether estrogen protects against pancreatic β-cell death caused by glucotoxicity via a decrease in the pancreatic β-cell RAS pathway. When INS-1 cells were cultured in a high glucose medium, cell death was significantly higher than when the cells were cultured in a basal glucose medium; similarly, there were also higher levels of AGTR1 and p47ph °x mRNA, and protein expression...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057680/the-association-of-renin-angiotensinogen-system-genes-polymorphisms-and-idiopathic-recurrent-pregnancy-loss
#16
Mohammad Mehdi Heidari, Mozhgan Sheikholeslami, Mahdieh Yavari, Mehri Khatami, Seyed Mohammad Seyedhassani
The most common complication of pregnancy is idiopathic recurrent pregnancy loss (RPL). To identify the contribution of gene polymorphisms to this condition, we evaluated the association between RPL and the angiotensinogen (AGT), angiotensin receptor 1 (AGTR1) and Angiotensinogen converting enzyme (ACE). In this case-control study, the frequency of AGT (rs4762 and rs699), AGTR1 (rs5186) and ACE insertion/deletion (rs4340) polymorphisms in 202 idiopathic RPL women was compared with 210 women with no history of abortion, using tetra-primer ARMS-PCR...
October 23, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29039830/-role-of-agtr1-a-c-polymorphism-in-the-development-of-atrial-fibrillation
#17
A V Kuskaeva, S Yu Nikulina, A A Chernova, N V Aksyutina, A P Kuskaev, I I Cherkashina
AIM: To investigate the AGTR1 A/C polymorphism associated with atrial fibrillation (AF) to form risk groups among patients who are prone to this disease. SUBJECTS AND METHODS: 90 probands with a confirmed diagnosis of AF and their 144 first-, second-, and third-degree relatives were examined. These families made up a study group. A control group was formed of 100 apparently healthy individuals without a history of cardiovascular diseases. Collection of medical history data and complaints, electrocardiography, electrocardiogram monitoring, as well as molecular genetic analysis, thyroid hormone tests were done in all the patients...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28915321/regulation-and-functions-of-the-renin-angiotensin-system-in-white-and-brown-adipose-tissue
#18
Mandana Pahlavani, Nishan S Kalupahana, Latha Ramalingam, Naima Moustaid-Moussa
The renin angiotensin system (RAS) is a major regulator of blood pressure, fluid, and electrolyte homeostasis. RAS precursor angiotensinogen (Agt) is cleaved into angiotensin I (Ang I) and II (Ang II) by renin and angiotensin converting enzyme (ACE), respectively. Major effects of Ang II, the main bioactive peptide of this system, is mediated by G protein coupled receptors, Angiotensin Type 1 (AGTR1, AT1R) and Type 2 (AGTR2, AT2R) receptors. Further, the discovery of additional RAS peptides such as Ang 1-7 generated by the action of another enzyme ACE2 identified novel functions of this complex system...
September 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28903744/renin-angiotensin-system-gene-polymorphisms-and-high-blood-pressure-in-lithuanian-children-and-adolescents
#19
Sandrita Simonyte, Renata Kuciene, Jurate Medzioniene, Virginija Dulskiene, Vaiva Lesauskaite
BACKGROUND: Epidemiological studies have demonstrated the influence of environmental factors on HBP in the population of Lithuanian children, although the role of genetic factors in hypertension has not yet been studied. The aim of this study was to assess the distribution of AGTR1, AGT, and ACE genotypes in the Lithuanian child population and to determine whether these genotypes have an impact on HBP in childhood. METHODS: This cross-sectional study enrolled 709 participants aged 12-15 years...
September 13, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28792482/association-and-interaction-effect-of-agtr1-and-agtr2-gene-polymorphisms-with-dietary-pattern-on-metabolic-risk-factors-of-cardiovascular-disease-in-malaysian-adults
#20
Roseline Wai Kuan Yap, Yoshihiro Shidoji, Wai Sum Yap, Motofumi Masaki
Gene-diet interaction using a multifactorial approach is preferred to study the multiple risk factors of cardiovascular disease (CVD). This study examined the association and gene-diet interaction effects of the angiotensin II type 1 receptor (AGTR1) gene (rs5186), and type 2 receptor (AGTR2) gene (rs1403543) polymorphisms on metabolic risk factors of CVD in Malaysian adults. CVD parameters (BMI, blood pressure, glycated hemoglobin, total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), and TC/HDL-C ratio), and constructed dietary patterns "vegetables, fruits, and soy diet" (VFSD), and "rice, egg, and fish diet" (REFD) were obtained from previous studies...
August 9, 2017: Nutrients
keyword
keyword
15206
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"