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https://www.readbyqxmd.com/read/29792847/the-polymorphisms-of-atoh-7-et-1-and-ace-in-non-arteritic-anterior-ischemic-optic-neuropathy
#1
Ting Chen, Jin Ma, Guangliang Shan, Yong Zhong
Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of acute optic neuropathy in the elderly. The role of the genetic polymorphisms of Atonal Homolog 7 (ATOH7), Endothelin-1 (ET-1) and Angiotensin Converting Enzyme (ACE) in NAION and the combined effects of the gene-gene and gene-medical comorbidities on NAION were not clear. We conducted a perspective, case-control study. 71 NAION patients and 142 age and sex-matched healthy controls were enrolled. Single nucleotide polymorphisms of ATOH7 (rs1900004), ET-1 (rs5370) and ACE (rs1799752) were identified by polymerase chain reaction (PCR) method and all PCR products were screened with Sanger sequencing...
May 21, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29792506/testing-the-validity-of-criminal-risk-assessment-tools-in-sexually-abusive-youth
#2
Steffen Barra, Cornelia Bessler, Markus A Landolt, Marcel Aebi
Although accurate risk appraisals are mandatory to provide effective treatment to juveniles who have sexually offended (JSOs), the current knowledge on the validity of risk assessment instruments for JSOs is inconclusive. We compared the predictive validities of the Juvenile Sex Offender Assessment Protocol II (J-SOAP II), the Estimate of Risk of Adolescent Sexual Offense Recidivism (ERASOR), and the Violence Risk Appraisal Guide-Revised (VRAG-R) scores concerning sexual, nonsexual-violent, and general criminal recidivism (based on both official and nonregistered reoffenses) in a consecutive sample of 597 male JSOs (Mage = 14...
May 24, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29792395/how-are-patients-with-heart-failure-treated-in-primary-care
#3
Hélène Vaillant-Roussel, Bruno Pereira, Sylvaine Gibot-Boeuf, Romain Eschalier, Claude Dubray, Rémy Boussageon, Philippe Vorilhon
OBJECTIVE: The aim of this study was to assess the adherence of general practitioners (GPs) to guidelines in patients with heart failure with reduced ejection fraction (HFrEF) and to describe GPs' prescribing behavior regarding patients with heart failure with preserved ejection fraction (HFpEF). MATERIALS AND METHODS: Cross-sectional study as part of the ETIC trial. Five classes of drugs were described: angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs); β-blockers (BBs); mineralocorticoid receptor antagonists (MRAs); diuretics (thiazide or loop diuretics); and digoxin...
May 24, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29792376/somatic-ace-regulates-self-renewal-of-mouse-spermatogonial-stem-cells-via-the-mapk-signaling-pathway
#4
Tingting Gao, Xin Zhao, Chenchen Liu, Binbin Shao, Xi Zhang, Kai Li, Jinyang Cai, Su Wang, Xiaoyan Huang
Spermatogonial stem cell (SSC) self-renewal is an indispensable part of spermatogenesis. Angiotensin I-converting enzyme (ACE) is a zinc dipeptidyl carboxypeptidase that plays a critical role in regulation of the renin-angiotensin system. Here, we used RT-PCR and Western blot analysis to confirm that somatic ACE (sACE) but not testicular ACE (tACE) is highly expressed in mouse testis before postpartum day 7 and in cultured SSCs. Our results revealed that sACE is located on the membrane of SSCs. Treating cultured SSCs with the ACE competitive inhibitor captopril was found to inhibit sACE activity, and significantly reduced the proliferation rate of SSCs...
May 24, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29792344/direct-formylation-of-2-pyridone-core-of-3-n-methylcytisine-via-duff-reaction-synthesis-of-9-enyl-9-ynyl-and-9-imino-derivatives
#5
Polina R Petrova, Alena V Koval'skaya, Alexander N Lobov, Inna P Tsypysheva
The first direct synthesis of 3-N-methyl-9-formylcytisine via electrophylic formylation is described. It is established, that Vilsmeier-Haack and Gatterman variants of this reaction are unsuccessful in the case with 3-substituted (-)-cytisine derivatives, but Duff procedure (with hexamethylenetetramine in trifluoroacetic acid) gives a possibility to obtain the target pseudo aromatic aldehyde with the 69% yield. Convenient precursors for [4 + 2]- or [3 + 2]-cycloaddition reactions are obtained by means of condensation of synthesized 3-N-methyl-9-formylcytisine with acetone, nitromethane and phosphorous ylides with yields from 70 to 87%...
May 24, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29791634/effects-of-health-education-in-the-elderly-with-mild-cognitive-impairment
#6
Francine Golghetto Casemiro, Diana Monteiro Quirino, Maria Angélica Andreotti Diniz, Rosalina Aparecida Partezani Rodrigues, Sofia Cristina Iost Pavarini, Aline Cristina Martins Gratão
OBJECTIVE: to analyze the effects of health education on both cognition and depressive/anxiety symptoms in the elderly with Mild Cognitive Impairment (MCI). METHOD: this is a randomized and controlled clinical trial. Participants (n=22) were recruited from a specialized outpatient clinic, and assigned into two groups: a Health Education Group (HEG) (n=10) and a Control Group (CG) (n=12). The participants were evaluated before and after the intervention, which was composed of classes and dynamics...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791447/development-of-an-rp-uhplc-pda-method-for-quantification-of-free-gossypol-in-cottonseed-cake-and-fungal-treated-cottonseed-cake
#7
Aparecido Almeida Conceição, Clemente Batista Soares Neto, José Antônio de Aquino Ribeiro, Felix Gonçalves de Siqueira, Robert Neil Gerard Miller, Simone Mendonça
Cottonseed cake biomass, which is a residue of oil extraction, is potentially appropriate for use as animal feed, given the high mineral, fibre and protein content. The presence of free gossypol, however, a toxic pigment in the glands of the cotton plant, limits use of this biomass for monogastric livestock. A promising method to detoxify cottonseed cake relies on fermentation by fungi, which can eliminate up to 100% of gossypol. In order to quantify trace levels of free gossypol in different cotton materials, including cottonseed cake treated with macrofungi, a simple and rapid chromatographic detection method was developed and validated...
2018: PloS One
https://www.readbyqxmd.com/read/29791008/the-pharmacology-pharmacokinetics-efficacy-and-adverse-events-associated-with-kava
#8
REVIEW
C Michael White
Kava is a plant with numerous kavapyrones that can induce pharmacologic effects and drug interactions through the cytochrome P450 and P-glycoprotein systems. Kava is used recreationally and for the treatment of anxiety. Clinical trials verify anxiolytic effects in excess of placebo, but the effects are not seen immediately and the optimal dose and dosing schedule needs to be determined. Clinical trials usually lasting for 4 weeks found generally good tolerability and safety; however, dermatologic, hepatologic, and cognitive adverse effects may occur...
May 23, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29790690/validation-of-the-portuguese-version-of-addenbrooke-s-cognitive-examination-iii-in-mild-cognitive-impairment-and-dementia
#9
Bruno Peixoto, Milene Machado, Patricia Rocha, Carla Macedo, António Machado, Élia Baeta, Gerly Gonçalves, Paulo Pimentel, Emanuela Lopes, Luis Monteiro
BACKGROUND: Cognitive assessment is central to the diagnosis of cognitive impairment and dementia, and it should be performed in all patients in the early stages of the disease. Recently, the 3rd version of Addenbrooke's Cognitive Examination (ACE-III) has been developed in order to improve the previous versions. OBJECTIVES: The aim of this study was to determine the psychometric properties of the Portuguese version of ACE-III, namely: reliability and discriminative validity (sensitivity and specificity) in the identification of mild cognitive impairment (MCI) and dementia, in comparison to other neuropsychological screening tests, as well as to establish its concurrent and divergent validity...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790603/hyperkalaemia-in-people-with-diabetes-occurrence-risk-factors-and-outcomes-in-a-danish-population-based-cohort-study
#10
R W Thomsen, S K Nicolaisen, K Adelborg, E Svensson, P Hasvold, E Palaka, L Pedersen, H T Sørensen
AIMS: To examine the incidence, risk factors and clinical outcomes of hyperkalaemia in people with diabetes in a real-world setting. METHODS: Using Danish health registries, we identified a population-based cohort of people with first-time drug-treated diabetes, in the period 2000-2012. First, the cumulative incidence of hyperkalaemia, defined as first blood test with potassium level >5.0 mmol/l after diabetes treatment initiation, was ascertained. Second, in a case-control analysis, risk factors were compared in people with vs without hyperkalaemia...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790580/preclinical-evaluation-of-potential-infection-imaging-probe-68-ga-ga-dota-k-a9-in-sterile-and-infectious-inflammation
#11
Karin M Nielsen, Nis P Jørgensen, Majbritt H Kyneb, Per Borghammer, Rikke L Meyer, Trine R Thomsen, Dirk Bender, Svend B Jensen, Ole L Nielsen, Aage K O Alstrup
The development of bacteria-specific infection radiotracers is of considerable interest to improve diagnostic accuracy and enabling therapy monitoring. The aim of this study was to determine if the previously reported radiolabelled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid (DOTA) conjugated peptide, [68 Ga]Ga-DOTA-K-A9 could detect a staphylococcal infection in vivo, and distinguish it from aseptic inflammation. An optimised [68 Ga]Ga-DOTA-K-A9 synthesis omitting the use of acetone was developed, yielding 93% ± 0...
May 23, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29790550/cs-2-co-3-promoted-methylene-insertion-into-disulfide-bonds-using-acetone-as-a-methylene-source
#12
Qian Chen, Guodian Yu, Xiaofeng Wang, Yulin Huang, Yan Yan, Yanping Huo
An efficient halogen-free Cs2CO3-promoted methylene insertion into disulfide bonds has been achieved using acetone as a methylene source under mild conditions. This method provides a convenient and practical route to dithioacetals in up to 96% yield with good functional group compatibility.
May 23, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29790085/white-matter-microstructure-in-bipolar-disorder-is-influenced-by-the-interaction-between-a-glutamate-transporter-eaat1-gene-variant-and-early-stress
#13
Sara Poletti, Irene Bollettini, Cristina Lorenzi, Alice Vitali, Silvia Brioschi, Alessandro Serretti, Cristina Colombo, Francesco Benedetti
Glutamate is the principal excitatory neurotransmitter in the central nervous system. In mature brains, it is critically involved in neuroplasticity and, at high levels, neurotoxicity. The concentrations of glutamate in the extracellular space are maintained at low physiological levels by molecular glutamate transporters (excitatory amino acid transporters-EAATs). Adverse childhood experiences (ACEs) are highly reported in bipolar disorder (BD) and interact with the glutamatergic system in the brain. The aim of the study is to investigate the effect of a glutamate transporter polymorphism EAAT2-181A > C (rs4354668) and exposure to ACE on white matter microstructure in patients with BD...
May 22, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29789929/mechanistic-simulation-of-batch-acetone-butanol-ethanol-abe-fermentation-with-in-situ-gas-stripping-using-aspen-plus%C3%A2
#14
Kwabena Darkwah, Sue E Nokes, Jeffrey R Seay, Barbara L Knutson
Process simulations of batch fermentations with in situ product separation traditionally decouple these interdependent steps by simulating a separate "steady state" continuous fermentation and separation units. In this study, an integrated batch fermentation and separation process was simulated for a model system of acetone-butanol-ethanol (ABE) fermentation with in situ gas stripping, such that the fermentation kinetics are linked in real-time to the gas stripping process. A time-dependent cell growth, substrate utilization, and product production is translated to an Aspen Plus batch reactor...
May 22, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29789916/two-dimensional-speckle-tracking-echocardiography-derived-strain-measurements-in-survivors-of-childhood-cancer-on-angiotensin-converting-enzyme-inhibition-or-receptor-blockade
#15
Jamie K Harrington, Marc E Richmond, Arielle W Fein, Serge Kobsa, Prakash Satwani, Amee Shah
Speckle tracking echocardiography (STE)-derived strain indices are believed to detect early cardiac dysfunction in survivors of childhood cancer and have potential to identify patients who may benefit from early heart failure treatment. However, effects of heart failure treatment on STE-derived strain measurements in this population are unknown. The aim of this study was to assess STE-derived strain measurements in survivors of childhood cancer treated with angiotensin converting enzyme inhibition or receptor blockade (ACEi/ARB)...
May 22, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29789676/the-angiotensin-i-converting-enzyme-insertion-deletion-in-polymorphic-element-codes-for-an-aluya5-rna-that-downregulates-gene-expression
#16
REVIEW
Fernando F P Mafra, Pedro P Gattai, Michel M Macedo, Marcelo A Mori, Ronaldo C Araujo
Angiotensin-I-converting enzyme (ACE) is involved in the synthesis and degradation of important bioactive peptides. The ACE gene has a 287-bp insertion/deletion polymorphism that controls ACE expression through a mechanism that remains elusive. In this study, we found that the 287-bp polymorphic element of the ACE gene, a member of the AluYa5 sub-family of Alu elements, codes for an RNA molecule that controls the levels of ACE mRNA. Transient transfection of a plasmid containing a CMV promoter upstream of the ACE polymorphic element resulted in significant expression of an AluYa5 RNA and reduced ACE mRNA expression as well as ACE enzymatic activity in AD 293 cells...
May 23, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29788394/rna-interference-of-the-muscle-actin-gene-in-bed-bugs-exploring-injection-versus-topical-application-for-dsrna-delivery
#17
Sanjay Basnet, Shripat T Kamble
Bed bugs are one the most troublesome household pests that feed primarily on human blood. RNA interference (RNAi) is currently being pursued as a potential tool for insect population management and has shown efficacy against some phytophagous insects. We evaluated the different techniques to deliver dsRNA specific to bed bug muscle actin (dsactin) into bed bugs. Initially, stability of dsRNA in human blood was studied to evaluate the feasibility of feeding method. Adult bed bugs were injected with dsRNA between last thoracic segment and first abdominal segment on the ventral side, with a dose of 0...
May 1, 2018: Journal of Insect Science
https://www.readbyqxmd.com/read/29788258/is-the-plasma-aldosterone-to-renin-ratio-associated-with-blood-pressure-response-to-treatment-in-general-practice
#18
Sabine C Käyser, Bianca W M Schalk, Wim J C de Grauw, Tjard R Schermer, Reinier P Akkermans, Jacques W M Lenders, Jaap Deinum, Marion C J Biermans
Background: Individualized antihypertensive treatment based on specific biomarkers such as renin may lead to more effective blood pressure control in patients with newly diagnosed essential hypertension. Recent studies suggested that the plasma aldosterone-to-renin ratio (ARR) may also be a candidate predictor for this purpose. Objective: To assess whether the ARR is associated with the blood pressure response to antihypertensive treatment in patients with newly diagnosed hypertension...
May 19, 2018: Family Practice
https://www.readbyqxmd.com/read/29788222/chromatographic-and-computational-studies-of-molecular-lipophilicity-and-drug-likeness-for-few-2-thioxo-1-3-thiazolidin-4-one-derivatives-and-their-analogs
#19
Robert Zakrzewski, Pawel Urbaniak, Arkadiusz Nowicki, Waldemar Tejchman
Hydrophobicity of the eight 2-thioxo-1,3-thiazolidin-4-one derivatives was determined experimentally by thin-layer chromatography and predicted by means of commercially available programmers. RM values were determined by reversed-phase thin-layer chromatography with using acetonitrile-water, methanol-water, acetone-water, propan-2-ol-water or 1,4-dioxane-water and compared with logP values calculated by using computer programs: HyperChem 8.0.10, Virtual Chemical Calculation Laboratory, ACD/LogP. The drug-likeness has been calculated using Molinspiration...
May 18, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29786638/impact-of-appointment-based-medication-synchronization-on-proportion-of-days-covered-for-chronic-medications
#20
Nancy Dao, Sun Lee, Micah Hata, Lord Sarino
Appointment-based medication synchronization (ABMS) programs have been associated with increased adherence and persistence to chronic medications. Adherence to statin therapy, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and non-insulin antidiabetic medications (NIDM) are used to determine a health plan's Centers for Medicare and Medicaid Services (CMS) Star Rating under a pay-for-performance model. The objective of this study was to evaluate the impact of implementing an ABMS program on overall pharmacy adherence measures for statins, ACEI/ARBs, and NIDM, as presented through the Electronic Quality Improvement Platform for Plans and Pharmacies (EQuIPP©) platform...
May 22, 2018: Pharmacy (Basel, Switzerland)
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