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https://www.readbyqxmd.com/read/28239616/optimization-of-nanoparticle-based-sers-substrates-through-large-scale-realistic-simulations
#1
Diego M Solís, José M Taboada, Fernando Obelleiro, Luis M Liz-Marzán, F Javier García de Abajo
Surface-enhanced Raman scattering (SERS) has become a widely used spectroscopic technique for chemical identification, providing unbeaten sensitivity down to the single-molecule level. The amplification of the optical near field produced by collective electron excitations -plasmons- in nanostructured metal surfaces gives rise to a dramatic increase by many orders of magnitude in the Raman scattering intensities from neighboring molecules. This effect strongly depends on the detailed geometry and composition of the plasmon-supporting metallic structures...
February 15, 2017: ACS Photonics
https://www.readbyqxmd.com/read/28239430/hiv-infected-children-in-the-asia-pacific-region-with-baseline-severe-anemia-antiretroviral-therapy-and-outcomes
#2
Pagakrong Lumbiganon, Pope Kosalaraksa, Torsak Bunupuradah, David Boettiger, Vonthanak Saphonn, Khanh H Truong, Nia Kurniati, Rawiwan Hansudewechakul, Viet C Do, Tavitiya Sudjaritruk, Nagalingeswaran Kumarasamy, Nantakar Kongstan, Nik K N Yusoff, Lam V Nguyen, Dewi K Wati, Kamarul Razali, Annette H Sohn, Azar Kariminia
BACKGROUND: Severe anemia is common among children infected with human immunodeficiency virus (HIV). The choice of antiretroviral (ART) regimen needs careful consideration. No information is available regarding the initial ART regimens used in the Asia-Pacific region and the rate of switch of ART regimens in HIV-infected children with severe anemia. OBJECTIVES: To study the initial ART regimens and the rate of switch of ART regimens used during the first 36 months in HIV-infected children with severe anemia and to evaluate their clinical and laboratory outcomes...
June 2016: Asian Biomedicine: Research, Reviews and News
https://www.readbyqxmd.com/read/28239010/antiretroviral-therapy-racial-disparities-among-publicly-insured-californians-with-hiv
#3
Raphael J Landovitz, Katherine A Desmond, Arleen A Leibowitz
Only 43% of Americans with HIV are virally suppressed; the rate is lower for African Americans, even among insured populations. This study uses 2010 Medicare and Medicaid data for HIV-positive Californians to examine how antiretroviral treatment (ART) relates to patient and provider characteristics. Logistic regressions isolated the effect of race/ethnicity on receipt of ART. Over 90% of the full sample received any ART. Nearly 80% of ART users received a recommended combination for at least half the year; half had a recommended combination for 90% of the year...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28238760/vascular-and-cellular-changes-accompany-altered-expression-of-angiopoietins-in-placenta-of-non-complicated-art-pregnancies
#4
Ahmed A M Abdel-Hamid, Alaa El-Din L Firgany, Yaser Mesbah, Mona Fm Soliman
BACKGROUND: ART is steadily performed for infertility cases and most of the previous researches have focused on complicated pregnancies. Nonetheless, few ones have concerned with placenta of ART in non-complicated pregnancies. OBJECTIVES: To investigate the expression of angiopoietins (ANG) and their receptor, TIE-2, in placenta of full-term non-complicated pregnancies having ART (n=28) versus those with spontaneous conception (n=28) together with the histological as well as morphometric analysis...
February 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28238336/human-papilloma-virus-dermatosis-in-human-immunodeficiency-virus-positive-patients-a-14-year-retrospective-study-in-965-patients
#5
Almudena Nuno-Gonzalez, Juan Emilio Losa Garcia, José Luis López Estebaranz, María Dolores Martin-Rios
INTRODUCTION: The incidence of the human papilloma virus (HPV) has not dropped in HIV-positive patients despite the discovery of antiretroviral therapy (ART). Our goal is to assess the prevalence of HPV in HIV patients and its relationship with the epidemiological and virological characteristics of HIV patients. PATIENTS AND METHODS: Retrospective cohort of 965 patients diagnosed with HIV from 1998 to 2012. We analyzed patients' demographic factors and factors related to the HPV...
February 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28238311/-effects-of-father-s-age-on-fertility-results-of-art-and-health-of-children
#6
F Boitrelle, P Plouvier, A Dumont, A-L Barbotin, J-M Rigot, J Belaïsch-Allart, G Robin
Many studies exist on the impact of female age on fertility, success of assisted reproductive technologies and on obstetric, fetal and neonatal adverse outcomes. Late paternity seems commonplace especially in the media… But there are reliable scientific data which confirm decline of fertility related to male age but also an increased risk of genetic diseases for the offspring. The objective of this article is to make a synthesis of the literature on this subject.
January 2017: Gynecol Obstet Fertil Senol
https://www.readbyqxmd.com/read/28238168/learning-representation-hierarchies-by-sharing-visual-features-a-computational-investigation-of-persian-character-recognition-with-unsupervised-deep-learning
#7
Zahra Sadeghi, Alberto Testolin
In humans, efficient recognition of written symbols is thought to rely on a hierarchical processing system, where simple features are progressively combined into more abstract, high-level representations. Here, we present a computational model of Persian character recognition based on deep belief networks, where increasingly more complex visual features emerge in a completely unsupervised manner by fitting a hierarchical generative model to the sensory data. Crucially, high-level internal representations emerging from unsupervised deep learning can be easily read out by a linear classifier, achieving state-of-the-art recognition accuracy...
February 25, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28237934/improving-kpca-online-extraction-by-orthonormalization-in-the-feature-space
#8
Joao B O Souza Filho, Paulo S R Diniz
Recently, some online kernel principal component analysis (KPCA) techniques based on the generalized Hebbian algorithm (GHA) were proposed for use in large data sets, defining kernel components using concise dictionaries automatically extracted from data. This brief proposes two new online KPCA extraction algorithms, exploiting orthogonalized versions of the GHA rule. In both the cases, the orthogonalization of kernel components is achieved by the inclusion of some low complexity additional steps to the kernel Hebbian algorithm, thus not substantially affecting the computational cost of the algorithm...
February 20, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28237931/a-multimodal-system-for-assessing-alertness-levels-due-to-cognitive-loading
#9
Anwesha Sengupta, Anirban Dasgupta, Aritra Chaudhuri, Anjith George, Aurobinda Routray, Rajlakshmi Guha
This paper proposes a scheme for assessing the alertness levels of an individual using simultaneous acquisition of multimodal physiological signals and fusing the information into a single metric for quantification of alertness. The system takes Electroencephalogram (EEG), high-speed image sequence and speech data as inputs. Certain parameters are computed from each of these measures as indicators of alertness and a metric by a fusion of the parameters for indicating alertness level of an individual at an instant is proposed...
February 20, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28237930/video-based-pedestrian-re-identification-by-adaptive-spatio-temporal-appearance-model
#10
Wei Zhang, Bingpeng Ma, Kan Liu, Rui Huang
Pedestrian re-identification is a difficult problem due to the large variations in a person's appearance caused by different poses and viewpoints, illumination changes, and occlusions. Spatial alignment is commonly used to address these issues by treating the appearance of different body parts independently. However, a body part can also appear differently during different phases of an action. In this paper we consider the temporal alignment problem, in addition to the spatial one, and propose a new approach that takes the video of a walking person as input and builds a spatio-temporal appearance representation for pedestrian re-identification...
February 20, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28237928/robust-multi-exposure-image-fusion-a-structural-patch-decomposition-approach
#11
Kede Ma, Hui Li, Hongwei Yong, Zhou Wang, Deyu Meng, Lei Zhang
We propose a simple yet effective structural patch decomposition (SPD) approach for multi-exposure image fusion (MEF) that is robust to ghosting effect. We decompose an image patch into three conceptually independent components: signal strength, signal structure, and mean intensity. Upon fusing these three components separately, we reconstruct a desired patch and place it back into the fused image. This novel patch decomposition approach benefits MEF in many aspects. First, as opposed to most pixel-wise MEF methods, the proposed algorithm does not require post-processing steps to improve visual quality or to reduce spatial artifacts...
February 20, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28237405/pharmacogenetics-of-antidepressant-drugs-state-of-the-art-and-clinical-implementation-recommendations-from-the-french-national-network-of-pharmacogenetics
#12
Sylvie Quaranta, Julien Dupouey, Romain Colle, Céline Verstuyft
Tailoring antidepressant drug therapy to each individual patient is a complex process because these drugs have adverse effects leading to discontinuation. Pharmacogenetics may provide useful information in routine practice for optimizing antidepressant treatment by helping limit toxic effects while maintaining efficacy. This review presents the usefulness of pharmacogenetic tests for P450 cytochromes CYP2C19 and CYP2D6 in psychiatric patients taking antidepressants. Depending on the level of evidence, the French National Network of Pharmacogenetics (RNPGx) has issued recommendations stating that pharmacogenetic tests for CYP2D6 and CYP2C19 genes are potentially useful in psychiatric patients treated with antidepressant drugs...
January 30, 2017: Thérapie
https://www.readbyqxmd.com/read/28237404/pharmacogenetics-in-cardiovascular-diseases-state-of-the-art-and-implementation-recommendations-of-the-french-national-network-of-pharmacogenetics-rnpgx
#13
Fabien Lamoureux, Thomas Duflot
The use of genomic markers to predict drug response and effectiveness has the potential to improve healthcare by increasing drug efficacy and minimizing adverse effects. Polymorphisms associated with inter-individual variability in drug metabolism, transport, or pharmacodynamics of major cardiovascular drugs have been identified. These include single nucleotide polymorphisms (SNP) affecting clinical outcomes in patients receiving antiplatelet agents, oral anticoagulants and statins. Based on clinical evidence supporting genetic testing in the management of cardiovascular diseases using these drug classes, this short review presents clinical guidance regarding current pharmacogenetics implementation in routine medical practice...
January 30, 2017: Thérapie
https://www.readbyqxmd.com/read/28237005/pediatric-epilepsy-neurology-functional-imaging-and-neurosurgery
#14
REVIEW
James M Mountz, Christina M Patterson, Mandeep S Tamber
In this chapter we provide a comprehensive review of the current role that functional imaging can have in the care of the pediatric epilepsy patient from the perspective of the epilepsy neurologist and the epilepsy neurosurgeon. In the neurology section, the diagnosis and classification of epilepsy adapted by the International League Against Epilepsy as well as the etiology and incidence of the disease is presented. The neuroimaging section describes how advanced nuclear medicine imaging methods can be synergized to provide a maximum opportunity to localize an epileptogenic focus...
March 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28236450/evaluation-of-4-thiazolidinone-derivatives-as-potential-reverse-transcriptase-inhibitors-against-hiv-1-drug-resistant-strains
#15
Rahul Suryawanshi, Sushama Jadhav, Nandini Makwana, Dipen Desai, Devidas Chaturbhuj, Archana Sonawani, Susan Idicula-Thomas, Vanangamudi Murugesan, Seturam B Katti, Srikanth Tripathy, Ramesh Paranjape, Smita Kulkarni
Rapid emergence of drug resistance is crucial in management of HIV infection limiting implementation of efficacious drugs in the ART regimen. Designing new molecules against HIV drug resistant strains is utmost essential. Based on the anti-HIV-1 activity, we selected four 4-thiazolidinone derivatives (S009-1908, S009-1909, S009-1911, S009-1912) and studied their interaction with reverse transcriptase (RT) from a panel of 10 clinical isolates (8 nevirapine resistant and two susceptible) using in silico methods, and inhibition pattern using in vitro cell based assays...
February 15, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28236279/oas-gene-family-expression-is-associated-with-hiv-related-neurocognitive-disorders
#16
C Sanfilippo, M R Pinzone, D Cambria, A Longo, M Palumbo, R Di Marco, F Condorelli, G Nunnari, L Malaguarnera, M Di Rosa
HIV-associated neurocognitive disorders are common in HIV-infected individuals, even in the combination antiretroviral therapy (c-ART) era. Several mechanisms are involved in neuronal damage, including chronic inflammation immune activation. Mammalian 2'-5'-oligoadenylate synthetase (OAS) genes are produced in response to interferon (IFN), mainly by monocytes, and exert their antiviral functions by activation of RNase L that degrades viral and cellular RNAs. In this study, we aimed at exploring OAS gene family RNA expression in simian immunodeficiency virus encephalitis (SIVE), in HIV-associated neurocognitive disorders (HAND), and in HIV-associate dementia (HAD)...
February 24, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28236233/application-of-the-attract-coarse-grained-docking-and-atomistic-refinement-for-predicting-peptide-protein-interactions
#17
Christina Schindler, Martin Zacharias
Peptide-protein interactions are abundant in the cell and form an important part of the interactome. Large-scale modeling of peptide-protein complexes requires a fully blind approach; i.e., simultaneously predicting the peptide-binding site and the peptide conformation to high accuracy. Here, we present one of the first fully blind peptide-protein docking protocols, pepATTRACT. It combines a coarse-grained ensemble docking search of the entire protein surface with two stages of atomistic flexible refinement...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28236103/minimally-invasive-treatments-of-painful-bone-lesions-state-of-the-art
#18
Antonio Barile, Francesco Arrigoni, Luigi Zugaro, Marcello Zappia, Roberto Luigi Cazzato, Julien Garnon, Nitin Ramamurthy, Luca Brunese, Afshin Gangi, Carlo Masciocchi
The role of the interventional radiology (IR) in the musculoskeletal system, and in particular in the bone, is a field of knowledge that is growing significantly in the last years with indications for treatment of both benign and malign lesions. In this paper, we review the state of the art of this application of the IR in the bone (bone metastasis and benign bone lesions) with discussion about all the techniques today used.
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28236053/almost-psychiatry-the-impact-of-teaching-child-and-adolescent-mental-health-studies-to-undergraduate-college-students
#19
Ursula Diamond, Christina A Di Bartolo, Emily Badin, Jess P Shatkin
OBJECTIVE: The Child and Adolescent Mental Health Studies (CAMS) program is housed in a Liberal Arts undergraduate college of a large research university. Psychiatrists, clinical psychologists, and social workers at the university's medical center teach the courses. The purpose of this study is to evaluate the extent to which CAMS encourages graduates of the program to pursue a career in child and adolescent mental health (CAMH). METHODS: In 2015-2016, graduates of the CAMS program were invited to participate in a mixed methods study...
February 24, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28235465/ovarian-reserve-testing-a-user-s-guide
#20
REVIEW
Reshef Tal, David B Seifer
Ovarian reserve is a complex clinical phenomenon that is influenced by age, genetics and environmental variables. Although it is challenging to predict the rate of an individual's ovarian reserve decline, clinicians are often asked for advice about fertility potential and/or recommendations regarding the pursuit of fertility treatment options. The purpose of this review is to summarize the state-of-the-art of ovarian reserve testing (ORT), providing a guide for the Ob/Gyn generalist and reproductive endocrinologist...
February 21, 2017: American Journal of Obstetrics and Gynecology
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