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https://www.readbyqxmd.com/read/29684709/the-role-of-natural-selection-in-shaping-genetic-variation-in-a-promising-chagas-disease-drug-target-trypanosoma-cruzi-trans-sialidase
#1
Joseph P Gallant, Raquel Asunción Lima-Cordón, Silvia Justi, Maria Carlota Monroy, Toni Viola, Lori Stevens
Rational drug design creates innovative therapeutics based on knowledge of the biological target to provide more effective and responsible therapeutics. Chagas disease, endemic throughout Latin America, is caused by Trypanosoma cruzi, a protozoan parasite. Current therapeutics are problematic with widespread calls for new approaches. Researchers are using rational drug design for Chagas disease and one target receiving considerable attention is the T. cruzi trans-sialidase protein (TcTS). In T. cruzi, trans-sialidase catalyzes the transfer of sialic acid from a mammalian host to coat the parasite surface membrane and avoid immuno-detection...
April 20, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29684680/licochalcone-a-an-effective-and-low-toxicity-compound-against-toxoplasma-gondii-in-vitro-and-in-vivo
#2
Hongfei Si, Chunyan Xu, Jili Zhang, Xukun Zhang, Bing Li, Xuzheng Zhou, Jiyu Zhang
Toxoplasma gondii, an obligate intracellular protozoan, is the causative agent of toxoplasmosis, which can cause serious public health problems. The current drugs used to treat toxoplasmosis have many limitations. This study evaluated the anti-T. gondii activity and potential mechanism of Licochalcone A (Lico A) in vitro and in vivo. The safe concentration of Lico A in HFF cells was determined by MTT cell viability assays. The presence of T. gondii was assessed by qPCR and Giemsa staining. Azithromycin and sulfadiazine, commonly used effective treatments, served as drug controls...
March 1, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29684665/anti-trypanosoma-cruzi-action-of-a-new-benzofuran-derivative-based-on-amiodarone-structure
#3
Andrea Pinto-Martinez, Vanessa Hernández-Rodríguez, Jessica Rodríguez-Durán, Elżbieta Hejchman, Gustavo Benaim
Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects. Thus, investigation efforts have been directed to the identification of new drug leads. In this context, Ca2+ regulating mechanisms have been postulated as targets for antiparasitic compounds, since they present paramount differences when compared to host cells. Amiodarone is an antiarrhythmic with demonstrated trypanocidal activity acting through the disruption of the parasite intracellular Ca2+ homeostasis...
April 11, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29684664/secnidazole-for-control-of-giardiasis-in-dairy-calves
#4
Andreia Volpato, Bruno F Fortuoso, Gabriela Campigotto, Patrícia Glombowsky, Nathieli B Bottari, Leandro S Lopes, Aleksandro Schafer Da Silva
The aim of this study was to verify whether secnidazole, given in a single oral dose (10 mg/kg), decreases or eliminates the excretion of Giardia duodenalis cysts. Holstein calves were raised from birth to 15 ± 2 days of age in individual stalls. Subsequently, 12 calves were grouped and housed in collective stalls. After seven days (day of life 21), we collected stool samples directly from the rectal ampulla in order to determine the degree of parasitic infection. Fecal examination was performed by a centrifugal-flotation technique, which allows for visualization and quantification of G...
April 11, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29684319/lipid-accumulation-product-index-in-hiv-infected-patients-a-marker-of-cardiovascular-risk
#5
Milena Maria Moreira Guimarães, Dirceu Bartolomeu Greco, Allyson Nogueira Moreira, Nathalia Sernizon Guimarães, Cláudia Maria Vilas Freire, Bruna Guimarães Rolfs, Lucas José de Campos Machado
The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels...
April 20, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29684241/recent-advances-in-understanding-leishmania-donovani-infection-the-importance-of-diverse-host-regulatory-pathways
#6
REVIEW
Amrita Saha, Moumita Basu, Anindita Ukil
Invasion of host cell by pathogens induce various intracellular signalling pathways. The host cell through the initiation of these signalling circuits desperately wants to get rid of the pathogen, whereas the pathogen tries to subvert these defence strategies to create an environment for their successful survival. Leishmania spp. is not an exception. Leishmania have to evolve a range of strategic mechanisms to neutralize macrophage defensive arsenals which enable the parasite to replicate within the phagolysosome of infected host...
April 23, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29683394/impact-of-4-deltamethrin-impregnated-dog-collars-on-the-prevalence-and-incidence-of-canine-visceral-leishmaniasis
#7
Thaís Aparecida Kazimoto, Sthenia Santos Albano Amora, Fabiano Borges Figueiredo, Jamille Maia E Magalhães, Yannara Barbosa Nogueira Freitas, Maressa Laíse Reginaldo Sousa, Anne Emanuelle Câmara da Silva Melo, Monique Paiva Campos, Nilza Dutra Alves, Guilherme Loureiro Werneck
In Brazil, visceral leishmaniasis is caused by the protozoan Leishmania infantum, primarily transmitted by Lutzomyia longipalpis and with the dog as its main urban reservoir. This study aims to evaluate the effectiveness of 4% deltamethrin-impregnated dog collars (DMC) DIC, Scalibor® 65 cm model and MSD manufacturer, on the prevalence and incidence of canine visceral leishmaniasis (CVL) and on the rate of infection of sandflies by L. infantum. The research was conducted in two areas of the municipality Mossoró, State of Rio Grande do Norte in Northeast of Brazil...
April 23, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29683289/antimicrobial-effects-of-photodynamic-therapy-an-overview
#8
Vanesa Pérez-Laguna, Ana J García-Malinis, Carmen Aspiroz, Antonio Rezusta, Yolanda Gilaberte
The microorganisms that cause infections are increasing their resistance to antibiotics. In this context, alternative treatments are necessary. The antimicrobial photodynamic therapy (aPDT) is a therapeutic modality based on photosensitizing molecules that end up generating reactive oxygen species that induce the destruction of the target cells when are irradiated with light of a suitable wavelength and at a proper dose. The cells targeted by aPDT are all types of microorganisms (bacteria, fungi and parasites) including viruses and has been proven effective against representative members of all of them...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29682142/left-ventricular-hydatid-cyst-mimicking-acute-coronary-syndrome
#9
Ali Fuat Tekin, Mehmet Sedat Durmaz, Mustafa Dağli, Sahabettin Akbayrak, Pelin Akbayrak, Bekir Turgut
Hydatid disease is caused by the larvae of Echinococcus granulosus . Domestic dogs and cats are the primary carriers of echinococcal organisms. In some particular regions of the world, this parasitic infection is still endemic. Despite the fact that hydatid disease is most frequently located in the liver (50%-70% of cases) and the lungs (20%-30% of cases), it can occur in any organ or tissue. However, intracardiac localization of hydatid cyst is very rare and it is found in less than 2% of the cases. Cardiac involvement can be caused by systemic or pulmonary circulation or direct spread from adjacent structures...
June 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29681249/endemic-infection-of-the-common-mynah-acridotheres-tristis-with-trichomonas-gallinae-the-agent-of-avian-trichomonosis
#10
Hassan Ali Farooq, Hammad Ahmad Khan, Abdulwahed Fahad Alrefaei, Kevin Morris Tyler
Avian trichomonosis is an architypal disease of wild columbids and those birds that predate them. Increasingly though, it has been reported in passerines; a recent and ongoing epidemic in the chaffinches and greenfinches of Europe and outbreaks amongst house finches, American goldfinches and purple finches in North America. The parasite, Trichomonas gallinae, causes lesions in the upper respiratory tract which can cause mortality associated with dehydration and emaciation. This paper reports for the first time, the widespread, endemic and often asymptomatic infection of common mynah (Acridotheres tristis) around the Faisalabad District, Pakistan...
April 23, 2018: Parasitology
https://www.readbyqxmd.com/read/29680940/prevalence-and-molecular-characterization-of-cryptosporidium-spp-and-giardia-duodenalis-in-1-2-month-old-highland-yaks-in-qinghai-province-china
#11
Geping Wang, Guanghua Wang, Xiuping Li, Xueyong Zhang, Gabriele Karanis, Yingna Jian, Liqing Ma, Panagiotis Karanis
Cryptosporidium and Giardia are ubiquitous parasites that infect humans and animals. Few reports are available on the prevalence of these two protozoan parasites in yaks (Bos grunniens). In this study, 344 faecal samples were collected from yaks with diarrhoea in the Chenduo and Nangqian counties of Qinghai Province, China. Cryptosporidium spp. and Giardia duodenalis were detected by light and immunofluorescence microscopy and nested PCR (nPCR). Fifteen samples were positive (4.5%) by Kinyoun staining, 40 (11...
April 21, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29680939/unveiling-the-oxidative-metabolism-of-achatina-fulica-mollusca-gastropoda-experimentally-infected-to-angiostrongylus-cantonensis-nematoda-metastrongylidae
#12
Vinícius Menezes Tunholi-Alves, Victor Menezes Tunholi, Juberlan Garcia, Esther Maria Mota, Rosane Nora Castro, Emerson Guedes Pontes, Jairo Pinheiro
For the first time, alterations in the oxidative metabolism of Achatina fulica experimentally infected with different parasite loads of Angiostrongylus cantonensis were determined. For this, the hemolymph activities of lactate dehydrogenase (LDH) and hexokinase and the glucose concentrations in the hemolymph, as well as the polysaccharide reserves in the digestive gland and cephalopedal mass, were assessed. Additionally, the contents of some carboxylic acids in the hemolymph of infected and uninfected snails were determined by high-performance liquid chromatography (HPLC), permitting a better understanding of the alterations related to the host's oxidative metabolism...
April 21, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29680937/intralesional-uridine-5-triphosphate-utp-treatment-induced-resistance-to-leishmania-amazonensis-infection-by-boosting-th-1-immune-responses-and-reactive-oxygen-species-production
#13
Camila Marques-da-Silva, Mariana M Chaves, Maria Luiza Thorstenberg, Vanessa R Figliuolo, Flávia S Vieira, Suzana P Chaves, José Roberto Meyer-Fernandes, Bartira Rossi-Bergmann, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva
Leishmania amazonensis is the etiologic agent of cutaneous leishmaniasis, an immune-driven disease causing a range of clinical symptoms. Infections caused by L. amazonensis suppress the activation and function of immune cells, including macrophages, dendritic cells, and CD4+ T cells. In this study, we analyzed the course of infection as well as the leishmanicidal effect of intralesional UTP treatment in L. amazonensis-infected BALB/c mice. We found that UTP treatment reduced the parasitic load in both footpad and lymph node sites of infection...
April 21, 2018: Purinergic Signalling
https://www.readbyqxmd.com/read/29679773/distinctive-infectious-complications-in-patients-with-central-nervous-system-lymphoma-undergoing-thiotepa-busulfan-and-cyclophosphamide-tbc-conditioned-autologous-stem-cell-transplantation
#14
Michael Scordo, Sejal M Morjaria, Eric R Littmann, Ankush Bhatia, Helen H Chung, Molly Maloy, Lisa M DeAngelis, Sergio A Giralt, Ying Taur, Craig S Sauter
We investigated the incidence of viral, fungal, bacterial, and parasitic infections observed in 57 patients with central nervous system lymphoma (CNSL) after TBC-ASCT and 79 patients with systemic NHL after traditional BEAM-ASCT. Twenty of 57 (35%) TBC-ASCT patients had detectable viremia with human herpesvirus 6 (HHV-6), cytomegalovirus (CMV), adenovirus (ADV), or BK virus (BKV), versus 9 of 79 (11%) BEAM-ASCT patients. Nine TBC-ASCT patients had clinically relevant viral infections (4 HHV-6, 2 CMV, 1 ADV, 2 BKV), versus 0 in the BEAM-ASCT group...
April 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29679594/design-and-synthesis-of-a-new-peptide-derived-from-fasciola-gigantica-cathepsin-l1-with-potential-application-in-serodiagnosis-of-fascioliasis
#15
Behnam Meshgi, Fatemeh Jalousian, Saeid Fathi, Zahra Jahani
Fascioliasis is a global parasitic disease that affects domestic animals and causes considerable economic losses in the process of domestic animal breeding in endemic regions. The cause of the disease involves a liver trematode of the genus Fasciola, which secretes materials into a host's body (mainly proteins) in order to protect it from the host's immune system. These materials can be involved in the migration, growth, and nutrition of the parasite. Among the expressive proteins of Fasciola, proteases have been introduced as the appropriate targets for diagnosis, treatment, and vaccination against parasites...
April 18, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29678683/long-term-affected-flat-oyster-ostrea-edulis-haemocytes-show-differential-gene-expression-profiles-from-na%C3%A3-ve-oysters-in-response-to-bonamia-ostreae
#16
P Ronza, A Cao, D Robledo, A Gómez-Tato, J A Álvarez-Dios, A F M Hasanuzzaman, M I Quiroga, A Villalba, B G Pardo, P Martínez
European flat oyster (Ostrea edulis) production has suffered a severe decline due to bonamiosis. The responsible parasite enters in oyster haemocytes, causing an acute inflammatory response frequently leading to death. We used an immune-enriched oligo-microarray to understand the haemocyte response to Bonamia ostreae by comparing expression profiles between naïve (NS) and long-term affected (AS) populations along a time series (1 d, 30 d, 90 d). AS showed a much higher response just after challenge, which might be indicative of selection for resistance...
April 17, 2018: Genomics
https://www.readbyqxmd.com/read/29678234/antibodies-to-in-silico-selected-gpi-anchored-theileria-parva-proteins-neutralize-sporozoite-infection-in-vitro
#17
James Nyagwange, Vishvanath Nene, Stephen Mwalimu, Sonal Henson, Lucilla Steinaa, Benjamin Nzau, Edwin Tijhaar, Roger Pelle
East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with a long-acting oxytetracycline. Although effective, this method has serious limitations; the immunity is parasite strain specific and immunized cattle can become life-long asymptomatic carriers of the parasite, posing risk for the spread of the disease...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29678224/evaluation-of-the-mucosal-inflammatory-responses-to-equine-cyathostomins-in-response-to-anthelmintic-treatment
#18
A E Steuer, A T Loynachan, M K Nielsen
Members of Cyathostominae are pervasive parasites of equids that can cause larval cyathostominosis, a potentially life-threatening disease that occurs when a multitude of encysted larvae synchronously excyst from the wall of the large intestine. Moxidectin and fenbendazole are the two current labeled drugs that target the encysted larval stages; however, there is limited knowledge of the local inflammatory response to the larvae and to the two treatments in clinically healthy horses. This study is the first to evaluate the local inflammatory response to cyathostomin larvae and to larvicidal treatment at 2 and 5 weeks post treatment...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29678203/quantitative-shotgun-proteomics-distinguishes-wound-healing-biomarker-signatures-in-common-carp-skin-mucus-in-response-to-ichthyophthirius-multifiliis
#19
Mona Saleh, Gokhlesh Kumar, Abdel-Azeem Abdel-Baki, Mohamed A Dkhil, Mansour El-Matbouli, Saleh Al-Quraishy
Ichthyophthirius multifiliis is a ciliated protozoan parasite recognized as one of the most pathogenic diseases of wild and cultured freshwater fish. Fish skin mucus plays a significant role against invading pathogens. However, the protein-based modulation against infection with I. multifiliis, of host fish at this barrier is unknown. Thus, we investigated the skin mucus proteome of common carp using a shotgun proteomic approach at days 1 and 9 after I. multifiliis exposure. We identified 25 differentially expressed proteins in infected carp skin mucus...
April 20, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29678200/correction-to-prevalence-of-and-risk-factors-for-malaria-filariasis-and-intestinal-parasites-as-single-infections-or-co-infections-in-different-settlements-of-gabon-central-africa
#20
Noé Patrick M'bondoukwé, Eric Kendjo, Denise Patricia Mawili-Mboumba, Jeanne Vanessa Koumba Lengongo, Christelle Offouga Mbouoronde, Dieudonné Nkoghe, Fousseyni Touré, Marielle Karine Bouyou-Akotet
Unfortunately, the original article [1] contained some errors. The table title of Tables 4, 5, 6, 7 were interchanged by mistake and displayed incorrectly in the article. The correct table titles of Tables 4, 5, 6, 7 can be found below.
April 20, 2018: Infectious Diseases of Poverty
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