keyword
MENU ▼
Read by QxMD icon Read
search

Chagas disease

keyword
https://www.readbyqxmd.com/read/29147831/plants-of-brazilian-restingas-with-tripanocide-activity-against-trypanosoma-cruzi-strains
#1
Robson Xavier Faria, André Luis Almeida Souza, Barbara Lima, Luis Armando Candido Tietbohl, Caio Pinho Fernandes, Raquel Rodrigues Amaral, Bettina Monika Ruppelt, Marcelo Guerra Santos, Leandro Rocha
Chagas disease is caused by the Trypanosoma cruzi affecting millions of people, and widespread throughout Latin America. This disease exhibits a problematic chemotherapy. Benznidazole, which is the drug currently used as standard treatment, lamentably evokes several adverse reactions. Among other options, natural products have been tested to discover a novel therapeutic drug for this disease. A lot of plants from the Brazilian flora did not contain studies about their biological effects. Restinga de Jurubatiba from Brazil is a sandbank ecosystem poorly studied in relation to plant biological activity...
November 17, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29147578/modelling-historical-changes-in-the-force-of-infection-of-chagas-disease-to-inform-control-and-elimination-programmes-application-in-colombia
#2
Zulma M Cucunubá, Pierre Nouvellet, Lesong Conteh, Mauricio Javier Vera, Victor Manuel Angulo, Juan Carlos Dib, Gabriel Jaime Parra-Henao, María Gloria Basáñez
Background: WHO's 2020 milestones for Chagas disease include having all endemic Latin American countries certified with no intradomiciliary Trypanosoma cruzi transmission, and infected patients under care. Evaluating the variation in historical exposure to infection is crucial for assessing progress and for understanding the priorities to achieve these milestones. Methods: Focusing on Colombia, all the available age-structured serological surveys (undertaken between 1995 and 2014) were searched and compiled...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29146550/temporal-variations-of-fluctuating-asymmetry-in-wing-size-and-shape-of-triatoma-infestans-populations-from-northwest-argentina
#3
Julieta Nattero, María Carla Cecere, Ricardo E Gürtler
Environmentally-induced developmental instability has frequently been assessed using fluctuating asymmetry (FA) methods. For Triatoma infestans, the major vector of Chagas disease, the combined effects of host-feeding sources and habitats affected wing developmental instability depending on sex in Figueroa villages, northwest Argentina. Here we investigated whether habitat, sex, season/year and insecticide applications affected wing developmental instability in T. infestans populations from Amamá and other rural villages of northwest Argentina over a four-year period...
November 13, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29145405/drivers-of-house-invasion-by-sylvatic-chagas-disease-vectors-in-the-amazon-cerrado-transition-a-multi-year-state-wide-assessment-of-municipality-aggregated-surveillance-data
#4
Raíssa N Brito, David E Gorla, Liléia Diotaiuti, Anália C F Gomes, Rita C M Souza, Fernando Abad-Franch
BACKGROUND: Insecticide spraying efficiently controls house infestation by triatomine bugs, the vectors of Trypanosoma cruzi. The strategy, however, is ineffective against sylvatic triatomines, which can transmit Chagas disease by invading (without colonizing) man-made structures. Despite growing awareness of the relevance of these transmission dynamics, the drivers of house invasion by sylvatic triatomines remain poorly understood. METHODS/FINDINGS: About 12,000 sylvatic triatomines were caught during routine surveillance in houses of Tocantins state, Brazil, in 2005-2013...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29144219/trypanosoma-sp-diversity-in-amazonian-bats-chiroptera-mammalia-from-acre-state-brazil
#5
Francisco C B Dos Santos, Cristiane V Lisboa, Samanta C C Xavier, Maria A Dario, Rair de S Verde, Armando M Calouro, André Luiz R Roque, Ana M Jansen
Bats are ancient hosts of Trypanosoma species and their flying ability, longevity and adaptability to distinct environments indicate that they are efficient dispersers of parasites. Bats from Acre state (Amazon Biome) were collected in four expeditions conducted in an urban forest (Parque Zoobotânico) and one relatively more preserved area (Seringal Cahoeira) in Rio Branco and Xapuri municipalities. Trypanosoma sp. infection was detected by hemoculture and fresh blood examination. Isolated parasite species were identified by the similarity of the obtained DNA sequence from 18S rDNA polymerase chain reaction and reference strains...
November 16, 2017: Parasitology
https://www.readbyqxmd.com/read/29141857/contemporary-characteristics-and-outcomes-in-chagasic-heart-failure-compared-with-other-nonischemic-and-ischemic-cardiomyopathy
#6
Li Shen, Felix Ramires, Felipe Martinez, Luiz Carlos Bodanese, Luis Eduardo Echeverría, Efraín A Gómez, William T Abraham, Kenneth Dickstein, Lars Køber, Milton Packer, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Michael R Zile, Pardeep S Jhund, Claudio R Gimpelewicz, John J V McMurray
BACKGROUND: Chagas' disease is an important cause of cardiomyopathy in Latin America. We aimed to compare clinical characteristics and outcomes in patients with heart failure (HF) with reduced ejection fraction caused by Chagas' disease, with other etiologies, in the era of modern HF therapies. METHODS AND RESULTS: This study included 2552 Latin American patients randomized in the PARADIGM-HF (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) and ATMOSPHERE (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure) trials...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29141765/bionomics-and-spatial-distribution-of-triatomine-vectors-of-trypanosoma-cruzi-in-texas-and-other-southern-states-usa
#7
Rachel Curtis-Robles, Sarah A Hamer, Sage Lane, Michael Z Levy, Gabriel L Hamer
Defining spatial and temporal occurrences of triatomine vectors of Trypanosoma cruzi, the agent of Chagas disease, in the US is critical for public health protection. Through a citizen science program and field collections from 2012 to 2016, we collected 3,215 triatomines, mainly from Texas. Using morphological and molecular approaches, we identified seven Triatoma species and report sex, length, and blood engorgement status. Many citizen-collected triatomines (92.9%) were encountered indoors, in peridomestic settings, or in dog kennels and represent spillover transmission risk of T...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141748/trypanosoma-cruzi-infection-induces-pannexin-1-channel-opening-in-cardiac-myocytes
#8
Iván Barría, Juan Güiza, Fredi Cifuentes, Pedro Zamorano, Juan C Sáez, Jorge González, José L Vega
Trypanosoma cruzi, the etiological agent of Chagas diseases, invades the cardiac tissue causing acute myocarditis and heart electrical disturbances. In T. cruzi invasion, the parasite induces [Ca(2+)]i transients in the host cells, an essential phenomenon for invasion. To date, knowledge on the mechanism that elicits transients of [Ca(2+)]i during the infection of cardiac myocytes has not been fully characterized. Pannexin1 (Panx1) channel are poorly selective channels found in all vertebrates that serve as a pathway for ATP release...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140309/biosensors-to-diagnose-chagas-disease-a-brief-review
#9
REVIEW
María-Isabel Rocha-Gaso, Luis-Jesús Villarreal-Gómez, Denis Beyssen, Frédéric Sarry, Marco-Antonio Reyna, Carlos-Napoleón Ibarra-Cerdeña
Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America's main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#10
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29136773/the-potential-use-of-melatonin-to-treat-protozoan-parasitic-infections-a-review
#11
REVIEW
Ahmad Daryani, Mahbobeh Montazeri, Abdol Satar Pagheh, Mehdi Sharif, Shahabeddin Sarvi, Azam Hosseinzadeh, Russel J Reiter, Ramtin Hadighi, Mohammad Taghi Joghataei, Habib Ghaznavi, Saeed Mehrzadi
Melatonin (N-acetyl-5-methoxytryptamine) is a circadian hormone produced in vertebrates by the pineal gland and other organs. Melatonin is believed to influence immune cells leading to modulation of the proliferative response of stimulated lymphocytes as well as cytokine production. Due to the antioxidant and immunomodulatory effects of melatonin, it is suggested that this molecule could be a therapeutic alternative agent to fight bacterial, viral, and parasitic infections by a variety of mechanisms. Herein, we review the effects of melatonin on the cell biology of protozoan parasites and host's immune response...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29134797/the-importance-of-collaboration-between-industry-academics-and-nonprofits-in-tropical-disease-drug-discovery
#12
Lori Ferrins, Michael P Pollastri
Collaborations between academic, industrial, and nonprofit companies can provide sufficient impetus to propel projects that have little economic return; such projects are prevalent in tropical disease drug discovery. In these collaborations, each partner contributes a unique set of skills and technical expertise which is advantageous to the project as a whole. Highly product-focused processes and specialized expertise sets dominate industry groups. When coupled with the strategic guidance from public-private partnerships and the academic tendency to work on high-risk projects with low financial rewards, a powerful combination results...
November 14, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29132413/germacranolide-type-sesquiterpene-lactones-from-smallanthus-sonchifolius-with-promising-activity-against-leishmania-mexicana-and-trypanosoma-cruzi
#13
Jerónimo L Ulloa, Renata Spina, Agustina Casasco, Patricia B Petray, Virginia Martino, Miguel A Sosa, Fernanda M Frank, Liliana V Muschietti
BACKGROUND: Leishmaniasis and Chagas disease are life-threatening illnesses caused by the protozoan parasites Leishmania spp. and Trypanosoma cruzi, respectively. They are known as "neglected diseases" due to the lack of effective drug treatments and the scarcity of research work devoted to them. Therefore, the development of novel and effective drugs is an important and urgent need. Natural products are an important source of bioactive molecules for the development of new drugs. In this study, we evaluated the activity of enhydrin, uvedalin and polymatin B, three sesquiterpene lactones (STLs) isolated from Smallanthus sonchifolius, on Leishmania mexicana (MNYC/BZ/62/M) and Trypanosoma cruzi (Dm28c)...
November 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29121981/intrinsic-dna-curvature-in-trypanosomes
#14
Pablo Smircich, Najib M El-Sayed, Beatriz Garat
BACKGROUND: Trypanosoma cruzi and Trypanosoma brucei are protozoan parasites causing Chagas disease and African sleeping sickness, displaying unique features of cellular and molecular biology. Remarkably, no canonical signals for RNA polymerase II promoters, which drive protein coding genes transcription, have been identified so far. The secondary structure of DNA has long been recognized as a signal in biological processes and more recently, its involvement in transcription initiation in Leishmania was proposed...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29121659/polyclonal-antibodies-for-the-detection-of-trypanosoma-cruzi-circulating-antigens
#15
Edith S Málaga-Machaca, Alessandra Romero-Ramirez, Robert H Gilman, Sofía Astupiña-Figueroa, Noelia Angulo, Alejandro Florentini, Cinthya J Lovon-Luque, Remo A Gonza, Ada Del Carpio-Sanz, Inés Cabello, Rosina Camargo, Fernando Recuenco, Liliam A Barrueta-Soria, Manuela R Verastegui, Maritza Calderon, Holger Mayta
BACKGROUND: Detection of Trypanosoma cruzi antigens in clinical samples is considered an important diagnostic tool for Chagas disease. The production and use of polyclonal antibodies may contribute to an increase in the sensitivity of immunodiagnosis of Chagas disease. METHODOLOGY/PRINCIPAL FINDINGS: Polyclonal antibodies were raised in alpacas, rabbits, and hens immunized with trypomastigote excreted-secreted antigen, membrane proteins, trypomastigote lysate antigen and recombinant 1F8 to produce polyclonal antibodies...
November 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29119655/targeting-host-mitochondria-a-role-for-the-trypanosoma-cruzi-amastigote-flagellum
#16
Gaelle Lentini, Nicolas Dos Santos Pacheco, Barbara A Burleigh
Trypanosoma cruzi is the kinetoplastid protozoan parasite that causes human Chagas disease, a chronic disease with complex outcomes including severe cardiomyopathy and sudden death. In mammalian hosts, T. cruzi colonizes a wide range of tissues and cell types where it replicates within the host cell cytoplasm. Like all intracellular pathogens, T. cruzi amastigotes must interact with its immediate host cell environment in a manner that facilitates access to nutrients and promotes a suitable niche for replication and survival...
November 8, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29118740/response-to-trypanosoma-cruzi-by-human-blood-cells-enriched-with-dentritic-cells-is-controlled-by-cyclooxygenase-2-pathway
#17
Sandra C H Lonien, Aparecida D Malvezi, Helena T Suzukawa, Lucy M Yamauchi, Sueli F Yamada-Ogatta, Luiz V Rizzo, Juliano Bordignon, Phileno Pinge-Filho
Chagas disease (Cd) or American human trypanosomiasis is caused by Trypanosoma cruzi and affects ~7 million people, mostly in Latin America. The infective trypomastigote forms of the parasite can invade several human blood cell populations, including monocytes and dendritic cells (DC). Although these cells display a wide functional diversity, their interactions with T. cruzi via cyclooxygenase (COX) and cyclic adenosine monophosphate (cAMP) dependent pathways have not been analyzed. To exploiting this mechanism, DC-enriched peripheral human blood mononuclear cell populations (DC-PBMC) were used as our model...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29117739/cardiac-autonomic-denervation-and-expression-of-neurotrophins-ngf-and-bdnf-and-their-receptors-during-experimental-chagas-disease
#18
Natália Katley Oliveira, Rodrigo Novaes Ferreira, Sara Delaine Nogueira Lopes, Egler Chiari, Elizabeth Ribeiro da Silva Camargos, Patricia Massara Martinelli
Although cardiac dysautonomia is a distinctive feature of Chagas disease, its clinical and functional significance is still being speculated. Neurotrophic factors are potentially involved; however, studies of their effect in this infection are rare. Ultrastructural abnormalities in autonomic varicosities, levels of both nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF), as well as the expression of their receptors, were analysed in the heart of a rat model of Trypanosoma infection. Predominantly, at the early stage of the infection, cardiac autonomic varicosities displayed several signs of degeneration parallel to the elevation of cardiac levels of NGF, as well as expression of the receptors TrkA and p75NTR...
November 8, 2017: Growth Factors
https://www.readbyqxmd.com/read/29116293/antioxidant-effect-of-morus-nigra-on-chagas-disease-progression
#19
Michelly Cristina Montenote, Vithor Zuccaro Wajsman, Yoichi Takaki Konno, Paulo César Ferreira, Regildo Márcio Gonçalves Silva, Altino Luiz Silva Therezo, Luciana Pereira Silva, Luciamáre Perinetti Alves Martins
Considering the widespread popular use of Morus nigra and the amount of scientific information on its antioxidant and anti-inflammatory activity, the effectiveness of this phytotherapeutic compound in the parasitemia progression during the acute phase of Chagas disease and its role in the development of the inflammatory process as well as its effects on the oxidative damage in the chronic phase of infection were evaluated. Thus, 96 male Swiss mice were randomly divided into eight groups, four groups were uninfected controls, and four groups were intraperitoneally infected with 5...
November 6, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29114029/rapid-selection-free-high-efficiency-genome-editing-in-protozoan-parasites-using-crispr-cas9-ribonucleoproteins
#20
Lia Carolina Soares Medeiros, Lilith South, Duo Peng, Juan M Bustamante, Wei Wang, Molly Bunkofske, Natasha Perumal, Fernando Sanchez-Valdez, Rick L Tarleton
Trypanosomatids (order Kinetoplastida), including the human pathogens Trypanosoma cruzi (agent of Chagas disease), Trypanosoma brucei, (African sleeping sickness), and Leishmania (leishmaniasis), affect millions of people and animals globally. T. cruzi is considered one of the least studied and most poorly understood tropical disease-causing parasites, in part because of the relative lack of facile genetic engineering tools. This situation has improved recently through the application of clustered regularly interspaced short palindromic repeats-CRISPR-associated protein 9 (CRISPR-Cas9) technology, but a number of limitations remain, including the toxicity of continuous Cas9 expression and the long drug marker selection times...
November 7, 2017: MBio
keyword
keyword
15197
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"