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Chagas disease

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https://www.readbyqxmd.com/read/28723933/comparative-repeatome-analysis-on-triatoma-infestans-andean-and-non-andean-lineages-main-vector-of-chagas-disease
#1
Sebastián Pita, Francisco Panzera, Pablo Mora, Jesús Vela, Ángeles Cuadrado, Antonio Sánchez, Teresa Palomeque, Pedro Lorite
Triatoma infestans is the most important Chagas disease vector in South America. Two main evolutionary lineages, named Andean and non-Andean, have been recognized by geographical distribution, phenetic and genetic characteristics. One of the main differences is the genomic size, varying over 30% in their haploid DNA content. Here we realize a genome wide analysis to compare the repetitive genome fraction (repeatome) between both lineages in order to identify the main repetitive DNA changes occurred during T...
2017: PloS One
https://www.readbyqxmd.com/read/28723905/evolution-of-anti-trypanosoma-cruzi-antibody-production-in-patients-with-chronic-chagas-disease-correlation-between-antibody-titers-and-development-of-cardiac-disease-severity
#2
Ingebourg Georg, Alejandro Marcel Hasslocher-Moreno, Sergio Salles Xavier, Marcelo Teixeira de Holanda, Eric Henrique Roma, Maria da Gloria Bonecini-Almeida
Chagas disease is one of the most important endemic infections in Latin America affecting around 6-7 million people. About 30-50% of patients develop the cardiac form of the disease, which can lead to severe cardiac dysfunction and death. In this scenario, the identification of immunological markers of disease progression would be a valuable tool for early treatment and reduction of death rates. In this observational study, the production of anti-Trypanosoma cruzi antibodies through a retrospective longitudinal follow-up in chronic Chagas disease patients´ cohort and its correlation with disease progression and heart commitment was evaluated...
July 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28723901/2b-rad-genotyping-for-population-genomic-studies-of-chagas-disease-vectors-rhodnius-ecuadoriensis-in-ecuador
#3
Luis E Hernandez-Castro, Marta Paterno, Anita G Villacís, Björn Andersson, Jaime A Costales, Michele De Noia, Sofía Ocaña-Mayorga, Cesar A Yumiseva, Mario J Grijalva, Martin S Llewellyn
BACKGROUND: Rhodnius ecuadoriensis is the main triatomine vector of Chagas disease, American trypanosomiasis, in Southern Ecuador and Northern Peru. Genomic approaches and next generation sequencing technologies have become powerful tools for investigating population diversity and structure which is a key consideration for vector control. Here we assess the effectiveness of three different 2b restriction site-associated DNA (2b-RAD) genotyping strategies in R. ecuadoriensis to provide sufficient genomic resolution to tease apart microevolutionary processes and undertake some pilot population genomic analyses...
July 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28722589/silencing-of-two-vitellogenin-genes-inhibits-oviposition-in-the-chagas-disease-vector-triatoma-infestans-hemiptera-reduviidae
#4
María J Blariza, Carla G Grosso, Beatriz A García
RNA interference caused by exogenous double-stranded RNA (dsRNA) is used to downregulate crucial genes to control insects. The reproductive success of all oviparous species depends on vitellogenin (Vg) biosynthesis and its accumulation in the developing oocytes. Adult females of Triatoma infestans were independently injected with two Vg dsRNAs (Vg1 dsRNA or Vg2 dsRNA) or nuclease-free water (control) 24 hours before feeding, and a group of adult females not injected was also analyzed (control). Vg1 and Vg2 messenger RNA silencing was verified by reverse transcription quantitative polymerase chain reaction...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722578/study-of-the-salivary-glands-in-triatominae-hemiptera-reduviidae-triatominae-their-color-and-application-to-the-chagas-disease-vector-evolution
#5
Jader de Oliveira, Amanda Ravazi, Eder Dos Santos Souza, Felipe Ferraz Figueiredo Moreira, Cleber Galvão, João Aristeu da Rosa, Kaio Cesar Chaboli Alevi
Chagas disease is caused by Trypanosoma cruzi and transmitted by feces of a triatomine that has the habit of defecating during blood feeding. The salivary glands of triatomines are important to hematophagy because their saliva is rich in anticoagulant and hemolytic proteins. The salivary glands of some Rhodnius species analyzed are reddish due to the presence of nitrophorins (antihemostatic activity). The present study aimed to analyze the color pattern of the salivary glands of 67 triatomine species to evaluate whether the presence of nitrophorins is a synapomorphy of Rhodnius or the tribe Rhodniini, or if it is shared with triatomines of the tribes Triatomini and Cavernicolini...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28720492/prevention-of-congenital-chagas-disease-by-benznidazole-pre-treatment-in-reproductive-age-women-an-observational-study
#6
María G Álvarez, Carlos Vigliano, Bruno Lococo, Graciela Bertocchi, Rodolfo Viotti
Since the decline in new cases of infection by insect/vector, congenital Chagas disease has become more relevant in the transmission of Chagas disease. Treatment with benznidazole significantly reduces the parasitemia, which constitutes an important factor linked to vertical transmission. The objective of this study was to evaluate whether treatment with benznidazole previously administered to women of childbearing age can prevent or reduce the incidence of new cases of congenital Chagas disease. An historical cohort study that included all women in reproductive age (15-45 years) assisted in our center was designed...
July 15, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28720489/simplified-membrane-feeding-of-bloodsucking-triatomines-hemiptera-reduviidae
#7
Glennyha F Duarte, Dayane B Macedo, Christian Luz
Laboratory-reared hematophagous triatomines that are the main vectors of Chagas disease are generally fed on small vertebrates or on blood-filled membrane devices. Such devices allow a large-scale rearing of these vectors without sacrificing host animals but are almost always expensive, fragile, not easily purchased, and usually difficult to use because they need to be sterilized before and carefully cleaned after each feeding. We present here a simple device to feed triatomines that is composed of a circular series of alternating short pieces of stainless steel and silicon tubing connected to a pump that circulates water heated at 50° C in a water bath...
July 15, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28719275/high-triatoma-brasiliensis-densities-and-trypanosoma-cruzi-prevalence-in-domestic-and-peridomestic-habitats-in-the-state-of-rio-grande-do-norte-brazil-the-source-for-chagas-disease-outbreaks
#8
Mauricio Lilioso, Elaine Folly-Ramos, Fabiana Lopes Rocha, Jorge Rabinovich, Claire Capdevielle-Dulac, Myriam Harry, Paula L Marcet, Jane Costa, Carlos Eduardo Almeida
AbstractA total of 2,431 Triatoma brasiliensis were collected from 39 populations of Paraíba (PB) and Rio Grande do Norte (RN) states, Brazil. In PB, Trypanosoma cruzi infection was not detected in either peridomestic or domestic vector populations. In contrast, in RN, T. brasiliensis was detected with high parasite prevalence in these ecotopes (30.7-40.0%). Moreover, peridomicile insect population densities were more than double the average densities of all other settings evaluated (19.17 versus < 8.94 triatomine/man-hour)...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28715142/cholinesterase-inhibition-reduces-arrhythmias-in-asymptomatic-chagas-disease
#9
Renata Rodrigues Teixeira de Castro, Graciema Porphirio, Sergio Salles Xavier, Ruy Silveira Moraes, Elton Luis Ferlin, Jorge Pinto Ribeiro, Antonio Claudio Lucas da Nóbrega
INTRODUCTION: Parasympathetic dysfunction may play a role in the genesis of arrhythmias in Chagas disease. AIM: This study evaluates the acute effects of pyridostigmine (PYR), a reversible cholinesterase inhibitor, on the occurrence of arrhythmias in patients with Chagas cardiac disease. METHOD: Following a double-blind, randomized, placebo-controlled, cross-over protocol, 17 patients (age 50±2 years) with Chagas cardiac disease type B underwent 24-hour Holter recordings after oral administration of either pyridostigmine bromide (45 mg, 3 times/day) or placebo (PLA)...
July 17, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28712508/health-care-importance-of-treponema-pallidum-chagas-disease-and-human-immunodeficiency-virus-1-among-amerindians-of-argentina-an-observational-study
#10
María E Eirin, Cecilia M Delfino, Williams R Pedrozo, Richard Malan, Alberto Puca, Ana M De Rissio, Rogelio D Espejo, María L Gallo Vaulet, Marcelo Rodríguez Fermepin, Mirna M Biglione, Carolina A Berini
The objective of this study was to estimate the prevalence of Treponema pallidum, Trypanosoma cruzi and Human immunodeficiency virus 1 (HIV-1) in five Amerindian populations of Argentina. A retrospective study was conducted among 857 Amerindian populations (112 Kollas, 298 Mbyá-guaraníes, 79 Sagua Huarpes, 368 Wichis) from 2007 to 2010. Screening and confirmation of T. pallidum, T. cruzi and HIV-1 were performed. T. pallidum and T. cruzi infections were detected in all communities with an overall prevalence rate of 4...
July 13, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28710652/comparison-between-inflammation-related-markers-in-peri-implant-crevicular-fluid-and-clinical-parameters-during-osseointegration-in-edentulous-jaws
#11
Amália M Bielemann, Raissa M Marcello-Machado, Fábio Renato Manzolli Leite, Frederico Canato Martinho, Otacílio Luiz Chagas-Júnior, Altair Antoninha Del Bel Cury, Fernanda Faot
OBJECTIVES: The aim of this study is to improve the understanding of interleukin mechanisms during osseointegration to enhance the monitoring of implant failure and success. Clinical parameters, implant stability, and cytokine levels in peri-implant crevicular fluid (PICF) during early bone healing after implant placement were investigated. MATERIAL AND METHODS: Sixty narrow implants were placed in mandible anterior region of 30 edentulous patients (67.23 ± 7...
July 14, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28706938/inhibitors-of-glycosomal-protein-import-provide-new-leads-against-trypanosomiasis
#12
COMMENT
Vishal C Kalel, Leonidas Emmanouilidis, Maciej Dawidowski, Wolfgang Schliebs, Michael Sattler, Grzegorz M Popowicz, Ralf Erdmann
Vector-borne trypanosomatid parasite infections in tropical and sub-tropical countries constitute a major threat to humans and livestock. Trypanosoma brucei parasites are transmitted by tsetse fly and lead to African sleeping sickness in humans and Nagana in cattle. In Latin American countries, Trypanosoma cruzi infections spread by triatomine kissing bugs lead to Chagas disease. Various species of Leishmania transmitted to humans by phlebotomine sandflies manifest in a spectrum of diseases termed Leishmaniasis...
July 3, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28706597/an-infrequent-cause-of-apical-ventricular-aneurysm-in-the-united-states
#13
Mohammed M Taleb
Chronic Chagas cardiomyopathy (CCC) is a late complication of Chagas disease with various manifestations including arrhythmia, heart failure, thromboembolism, and stroke. In a patient with symptoms of heart failure and left ventricular apical aneurysm unexplained by structural heart or coronary vascular abnormalities, CCC should be strongly considered and inquiry made about exposure status. Typical electrocardiographic findings of bundle branch block, complete heart blocks, and ventricular arrhythmia are helpful clues...
April 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28705488/prevalence-of-trypanosoma-cruzi-infection-in-dogs-and-small-mammals-in-nuevo-le%C3%A3-n-mexico
#14
Lucio Galaviz-Silva, Roberto Mercado-Hernández, José J Zárate-Ramos, Zinnia J Molina-Garza
Chagas disease, caused by the protozoan Trypanosoma cruzi, is an important public health concern in areas extending from South America northward into the southern United States of America. Although this hemoflagellate has many wild and domestic mammalians reported as reservoir hosts, studies on this subject are scarce in Nuevo León state, a region located in northeastern Mexico. This cross-sectional study showed that the general prevalence of T. cruzi infection in Nuevo León state was 14.5% (35/241), this percentage matching the ones determined by PCR and traditional diagnostics...
July 10, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28700051/pharmacotherapeutic-follow-up-of-patients-with-chagas-disease-using-benznidazole-drug-related-problems-and-pharmaceutical-interventions
#15
João Paulo Ramalho Correia, Alanna Carla da Costa, Eduardo Arrais Rocha, Ana Rosa Pinto Quidute, Darlan da Silva Cândido, Ângela Maria de Souza Ponciano, Marta Maria de França Fonteles, Maria de Fátima Oliveira
INTRODUCTION: Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory study conducted at the Pharmaceutical Care Service for Chagas disease patients of the Federal University of Ceará. Drug-related problems (DRPs) and pharmaceutical interventions (PIs) were classified according to the Second Consensus of Granada...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28700045/chagas-disease-review-of-needs-neglect-and-obstacles-to-treatment-access-in-latin-america
#16
Eloan Pinheiro, Lucia Brum-Soares, Renata Reis, Juan-Carlos Cubides
After more than one century since its discovery, Chagas disease is still extremely prevalent in 21 Latin American countries. Chagas disease is one of the most concerning public health problems in Latin America; the overall cost of CD treatment is approximately 7 billion United States dollars per year and it has a strong social impact on populations. Little progress has been made regarding the access to diagnosis and treatment at the primary health care level, calling into question the current policies to ensure the right to health and access to essential medications...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28700043/facing-chagas-disease
#17
EDITORIAL
João Carlos Pinto Dias
No abstract text is available yet for this article.
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28700000/ticks-infesting-captive-and-free-roaming-wild-animal-species-at-the-s%C3%A3-o-paulo-zoo-s%C3%A3-o-paulo-brazil
#18
Irys Hany Lima Gonzalez, Marcelo Bahia Labruna, Carolina Romeiro Fernandes Chagas, Paula Andrea Borges Salgado, Cauê Monticelli, Luan Henrique Morais, Amanda Alves de Moraes, Thatiane Cristina Antunes, Patrícia Locosque Ramos, Thiago Fernandes Martins
Ticks are ectoparasites of worldwide distribution that affect vertebrates and can transmit pathogens to animals and humans. The Zoological Park Foundation of São Paulo (FPZSP) is located in a Conservation Unit in one of the most important remaining fragments of the Atlantic Rainforest biome in the suburbs of São Paulo, Brazil. The FPZSP houses more than 3,000 wild animals on exhibit, in breeding programs and in environmental education programs, and also attracts migratory birds and free-roaming wildlife. This study focused on identifying the diversity of tick species that infest captive and free-roaming animals at the FPZSP...
July 10, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28699977/pacemaker-implants-in-children-and-adolescents-with-chagas-disease-in-brazil-18-year-incidence
#19
Carolina Christianini Mizzaci, Thiago Gonçalves Schroder E Souza, Gabriel Pelegrineti Targueta, Ana Paula Frederico Tótora, Juan Carlos Pachón Mateos, José Carlos Pachon Mateos
Background: Chagas disease continues to be a serious public health problem, and accounts for 25-30% of the indications for cardiac stimulation in Brazil. Objective: To assess clinical and epidemiological characteristics of patients with Chagas disease, younger than 18 years, who had undergone pacemaker implantation in Brazil between 1994 and 2011, and its temporal trend. Methods: This was a cross-sectional analysis of data from the Brazilian Pacemaker Registry database...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28697990/avian-antibodies-igy-against-trypanosoma-cruzi-purification-and-characterization-studies
#20
Thirssa H Grando, Matheus D Baldissera, Mariângela F de Sá, Guilherme do Carmo, Bianca Carolina Z Porto, Gisele S V Aguirre, Maria Isabel de Azevedo, Francielli P K de Jesus, Janio M Santurio, Michele R Sagrillo, Lenita Moura Stefani, Silvia Gonzalez Monteiro
Trypanosoma cruzi is a flagellated protozoan belonging to the Trypanosomatidae family, the etiologic agent of Chagas disease. Currently, there is neither a licensed vaccine nor effective treatment, characterizing an unmet clinical need. The IgY refers to the egg yolk immunoglobulin (Y=yolk) and its production and use are subjects of many studies due to the diversity of its diagnostic and therapeutic applications. Several researchers have shown that the use of specific IgY may prevent and/or control infectious and parasitic diseases...
July 8, 2017: Journal of Immunological Methods
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