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https://www.readbyqxmd.com/read/28910998/abnormal-uterine-bleeding
#1
Ying Cheong, Iain T Cameron, Hilary O D Critchley
Introduction: It is not uncommon for a woman to suffer from abnormal uterine bleeding (AUB) or heavy menstrual bleeding (HMB) at some point during her lifetime. Once pathology is excluded, in practice, management needs to be individualised, taking into account the improvement of the woman's symptoms and quality of life. Sources of data: Peer-reviewed journals, governmental and professional society publications. Areas of agreement: There is now agreement on a structured, universal approach to the diagnosis of AUB, with the aide memoirs PALM (polyps, adenomyosis, leiomyoma, malignancy) and COEIN (coagulopathies, ovulatory dysfunction, endometrial, iatrogenic, not otherwise classified)...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28905842/malignant-perivascular-epithelioid-cell-tumor-of-the-orbit-report-of-a-case-and-review-of-literature
#2
Md Shahid Alam, Bipasha Mukherjee, S Krishnakumar, Jyotirmay Biswas
Perivascular epithelioid cell tumor (PEComa) is a rare neoplasm considered to arise from myomelanocytic cell lineage. The uterus is reportedly the most common site to be involved. Orbital PEComa is extremely rare with only two cases reported till date. A 5-year-old male presented with a right medial orbital mass for the last 6 months. The patient was diagnosed with alveolar soft part sarcoma elsewhere. Magnetic resonance imaging features were suggestive of lymphangioma with bleeding. The excision biopsy revealed multiple tumor cells comprising epithelioid cells with clear cytoplasm, along with nuclear atypia and mitosis...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905674/angioleiomyoma-of-uterus-a-clinicopathologic-study-of-6-cases
#3
Mayank Gupta, Mayur Suryawanshi, Ramani Kumar, Abraham Peedicayil
BACKGROUND AND OBJECTIVES: Angioleiomyoma is a benign perivascular neoplasm commonly involving subcutaneous tissue of extremities, head, and trunk region. They rarely involve the female genital tract. This study analyses clinicopathological features of 6 cases of uterine angioleiomyoma. METHODS: Routine sections of 6 cases were reviewed and immunohistochemical markers namely muscle-specific actin, h-caldesmon, desmin, CD10, WT-1, HMB-45, and melan-A were done. RESULTS: Of the 6 cases, 4 cases had tumor involving the corpus and 2 cases had tumor in the cervix...
September 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28899738/angiomyomatous-hamartoma-of-lymph-nodes-revisited-clinico-pathologic-study-of-21-cases-emphasizing-its-distinction-from-lymphangioleiomyomatosis-of-lymph-nodes
#4
Michelle Moh, Ankur Sangoi, Joseph T Rabban
Angiomyomatous hamartoma of lymph nodes (AMH-LN) is an uncommon benign proliferation of smooth muscle, blood vessels, collagenous stroma and adipocytes, most commonly affecting inguinal LN. A similar constellation of cell types constitutes various members of the perivascular epithelioid cell tumor (PEComa) family, including lymphangioleiomyomatosis (LAM) which can involve LN in women. Because some LN-LAM patients have tuberous sclerosis complex (TSC) and/or other PEComa family lesions, it is clinically relevant to distinguish LN-LAM from AMH-LN...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28893044/immuno-histochemical-and-quantitative-study-of-melanocytes-and-melanin-granules-in-oral-epithelial-dysplasia
#5
Swapna Honwad, S V Ravi, Mandana Donoghue, Manjiri Joshi
INTRODUCTION: Oral Epithelial dysplasia (OED) is a potentially malignant disorder that is characterized by the presence of architectural and cytological changes. One of the prime factors responsible for the development of these lesions is the usage of tobacco. A variety of factors provide protective mechanism in order to prevent the effects of chemotoxic agents including tobacco products of which, melanin pigmentation is one of the vital elements. AIM: Role of melanocytes in progression of OED has remained unclear, so the present study was done to evaluate density of melanocyte and melanin granules in different grades of epithelial dysplasia and to correlate both findings with different grades of epithelial dysplasia...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28877071/uncommon-localization-of-extrarenal-xp11-2-translocation-associated-renal-cell-carcinoma-rcc-case-report
#6
Jaudah Ahmed Al-Maghrabi, Mohamad Nidal Khabaz
The World Health Organization has recognized Xp11.2 translocation-associated renal cell carcinoma (RCC) as a distinct neoplasm that arises within the kidney. Although many reports of extrarenal carcinoma may be found in the literature, to the best of our knowledge, Xp11 translocation-associated RCC with intact kidneys has not been documented. This report describes a multilobulated right retroperitoneal soft tissue mass (7.9×5.3×12.6 cm) of a 37-year-old man complaining of abdominal pain in the right side...
September 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28877054/melanotic-translocation-renal-cell-carcinoma-with-a-novel-arid1b-tfe3-gene-fusion
#7
Tatjana Antic, Jerome B Taxy, Mir Alikhan, Jeremy Segal
A 36-year-old male was found to have a 7.0 cm left upper pole renal mass on renal ultrasound. Following nephrectomy, the mass was grossly ill-demarcated, friable and red-brown, invading renal parenchyma, hilar fat and the renal vein. Microscopically, the tumor had a nested and papillary architecture. The cells demonstrated abundant clear and eosinophilic cytoplasm and focal intracytoplasmic melanin pigment. Nucleoli were prominent. By immunohistochemistry, the tumor was positive for TFE3; HMB-45 stained approximately 5% of tumor cells corresponding to the histologic melanin pigment, which was confirmed with Fontana-Masson stain with bleach...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28873279/differences-in-bleeding-phenotype-and-provider-interventions-in-postmenarchal-adolescents-when-compared-to-adult-women-with-bleeding-disorders-and-heavy-menstrual-bleeding
#8
L V Srivaths, Q C Zhang, V R Byams, J E Dietrich, A H James, P A Kouides, R Kulkarni
INTRODUCTION: Due to lack of patient/health care provider awareness causing delayed diagnosis, the bleeding phenotype and provider interventions in adolescents with heavy menstrual bleeding (HMB) and bleeding disorders (BD) may be different when compared to adults. AIM: The aim of this study was to compare/characterize bleeding phenotype and provider interventions in postmenarchal adolescents < 18 years and premenopausal adults ≥ 18 years with HMB and BD...
September 5, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28858896/evaluation-and-management-of-heavy-menstrual-bleeding-in-adolescents
#9
Lisa M Moon, Gisselle Perez-Milicua, Jennifer E Dietrich
PURPOSE OF REVIEW: Heavy menstrual bleeding (HMB) is a common condition in women of reproductive age; however, adolescents with this issue present unique challenges in both diagnosis and management. Much of the research into this topic focuses on the adult population, with variable applicability to adolescents. There are currently no standard guidelines for the work up and treatment of adolescents with HMB. RECENT FINDINGS: Current research into this topic has explored the utilization of standardized protocols in the evaluation of HMB in adolescents, the efficacy of various hormonal, nonhormonal, and surgical treatment modalities, and the benefits of a multidisciplinary approach...
October 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28802002/congenital-neurocristic-cutaneous-hamartoma-with-poliosis-a-case-report
#10
Lauren M Wilson, Knox J Beasley, Timothy C Sorrells, Viviana V Johnson
Neurocristic Cutaneous Hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. 1 2 We report the case of a 57-year-old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of two punch biopsies yielded features consistent with NCH. Histopathology revealed schwannian-differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively with S-100 and the stroma showed a prominent CD34 stain...
August 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28752676/fine-needle-aspiration-findings-of-a-rare-hematopoietic-neoplasm-presenting-as-obstructive-jaundice
#11
Jessica Tracht, Ali M Ahmed, Frida Rosenblum Donath
A 51-year-old female who presented with obstructive jaundice was found to have masses in the pancreatic head and tail as well as suspicious liver and periaortic masses on imaging. Aspiration cytology of the pancreatic tail mass showed abundant large single cells with vacuolated eosinophilic cytoplasm, marked nuclear pleomorphism, large bizarre irregular nuclei, binucleation, and prominent nucleoli. Numerous cells also showed intracytoplasmic black to brown pigmentation. A cell block was obtained and extensive immunohistochemical staining was performed...
July 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28742378/effect-of-the-various-steps-in-the-processing-of-human-milk-in-the-concentrations-of-iga-igm-and-lactoferrin
#12
Gerardo Arroyo, Kevin Alexander Ortiz Barrientos, Karla Lange, Federico Nave, Gabriela Miss Mas, Pamela Lam Aguilar, Miguel Angel Soto Galindo
INTRODUCTION: Human milk immune components are unique and important for the development of the newborn. Milk processing at the Human Milk Banks (HMB), however, causes partial destruction of immune proteins. The objective of this study was to determine the effects that heating during the milk processing procedure at the HMB had on the concentrations of IgA, IgM, and lactoferrin at three critical points in time. MATERIALS AND METHODS: Fifty milk samples (150 mL) were collected from voluntary donors at the HMB at the Hospital Nacional Pedro de Bethancourt, located in Antigua Guatemala...
September 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28708126/the-effect-of-a-12-week-beta-hydroxy-beta-methylbutyrate-hmb-supplementation-on-highly-trained-combat-sports-athletes-a-randomised-double-blind-placebo-controlled-crossover-study
#13
Krzysztof Durkalec-Michalski, Jan Jeszka, Tomasz Podgórski
The aim of this study was to verify the effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on physical capacity, body composition and the value of biochemical parameters in highly-trained combat sports athletes. Forty-two males highly-trained in combat sports were subjected to 12 weeks of supplementation with HMB and a placebo in a randomized, placebo controlled, double-blind crossover manner. Over the course of the experiment, aerobic and anaerobic capacity was determined, while analyses were conducted on body composition and levels of creatine kinase, lactate dehydrogenase, testosterone, cortisol and lactate...
July 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28705993/effects-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-on-skeletal-muscle-mitochondrial-content-and-dynamics-and-lipids-after-10-days-of-bed-rest-in-older-adults
#14
Robert A Standley, Giovanna Distefano, Suzette L Pereira, Min Tian, Owen J Kelly, Paul M Coen, Nicolaas E P Deutz, Robert R Wolfe, Bret H Goodpaster
Loss of muscle mass during periods of disuse likely has negative health consequences for older adults. We have previously shown that β-hydroxy-β-methylbutyrate (HMB) supplementation during 10 days of strict bed rest (BR) attenuates the loss of lean mass in older adults. To elucidate potential molecular mechanisms of HMB effects on muscle during bed rest and resistance training rehabilitation (RT), we examined mediators of skeletal muscle mitochondrial dynamics, autophagy and atrophy, and intramyocellular lipids...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28696501/long-term-incidence-of-hysterectomy-following-endometrial-resection-or-endometrial-ablation-for-heavy-menstrual-bleeding
#15
Emmanouil Kalampokas, Sarah McRobbie, Fiona Payne, David E Parkin
OBJECTIVE: To estimate the incidence of hysterectomy following endometrial resection or endometrial ablation (ERA). METHODS: The present retrospective study enrolled women who underwent ERA for benign heavy menstrual bleeding (HMB) at Aberdeen Royal Infirmary, UK, between February 1, 1990, and December 31, 1997; follow-up data to the end of 2015 were included from the pathology laboratory report system from the single pathology laboratory in the region. Data were compared between patients who did or did not require a hysterectomy after ERA...
July 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28695686/imprint-cytology-of-clear-cell-sarcoma-like-tumor-of-the-gastrointestinal-tract-in-the-small-intestine-a-case-report
#16
Takashi Kato, Shin Ichihara, Hiroko Gotoda, Shunji Muraoka, Terufumi Kubo, Shintaro Sugita, Tadashi Hasegawa
Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) is an extremely rare malignant neoplasm in the digestive tract. Its cytomorphologic features have never previously been reported. Here, we describe a case of CCSLGT, including its cytologic examination findings. A 47-year-old woman presented with a mass in the small intestine, which was resected and sent for imprint cytology. Imprint smears revealed tumor cells with light eosinophilic or clear cytoplasm in a necrotic background. Many of the tumor cells were arranged in a perivascular growth with a pseudopapillary formation, and there were some non-neoplastic osteoclast-like giant cells...
July 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28691938/genetic-versus-epigenetic-brca1-silencing-pathways-clinical-effects-in-primary-ovarian-cancer-patients-a-study-of-the-tumor-bank-ovarian-cancer-consortium
#17
Tingting Sun, Ilary Ruscito, Desislava Dimitrova, Radoslav Chekerov, Hagen Kulbe, Udo Baron, Véronique Blanchard, Pierluigi Benedetti Panici, Silvia Darb-Esfahani, Jalid Sehouli, Sven Olek, Elena Ioana Braicu
OBJECTIVES: The aim of the present study was to assess in a large cohort of primary epithelial ovarian cancer patients the incidence and the clinical effect of BRCA1 genetic and epigenetic silencing mechanisms. METHODS: A total of 188 primary epithelial ovarian cancer patients, treated between 2000 and 2011 at the Charité University Hospital of Berlin, were included. The patients' tumor and blood samples were obtained from the Tumor Bank Ovarian Cancer Network (www...
July 6, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28683706/sarcopenia-what-should-a-pharmacist-know
#18
Alfonso J Cruz-Jentoft
Sarcopenia (or muscle insufficiency) is a geriatric syndrome characterized by a progressive and generalized loss of skeletal muscle mass and function which has adverse consequences, particularly physical disability, falls and death. It can develop slowly, as a chronic condition that emerges over many years, or acutely, generally due to immobilization associated with an acute disease. The physiopathology of sarcopenia is complex, and affects both the muscle and its neurological and hormonal regulation...
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28680453/discrepancies-in-publications-related-to-hmb-fa-and-atp-supplementation
#19
Jeremy A Gentles, Stuart M Phillips
This letter addresses a number of discrepancies found in several publications related HMB-FA and ATP supplementation.
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28678159/computational-investigation-into-the-interactions-of-traditional-chinese-medicine-molecules-of-wenqingyin-with-glur2
#20
Yu-Hui Tseng, Po-Hsiang Chuang, Yu-Ren Huang, Cheng-Lung Chen
Docking and molecular dynamics simulations have been carried out to investigate the interaction of a traditional Chinese medicine, WenQingYin, with the glutamate receptor 2 (GluR2) subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Four representative drug components of WenQingYin, namely 2-(3,4-dihydroxyphenyl)-5,6,7-trihydroxy-4H-chromen-4-one (PHF), 4-hydroxy-3-methoxybenzoic acid (HMB), 4-(2,3-dihydroxy-3-methylbutoxy)-7H-furo[3,2-g]chromen-7-one (DHMBP) and methyl 7-formylcyclopenta[c]pyran-4-carboxylate (cerbinal), and their complexes with GluR2 were simulated...
July 5, 2017: International Journal of Molecular Sciences
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