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https://www.readbyqxmd.com/read/28742378/effect-of-the-various-steps-in-the-processing-of-human-milk-in-the-concentrations-of-iga-igm-and-lactoferrin
#1
Gerardo Arroyo, Kevin Alexander Ortiz Barrientos, Karla Lange, Federico Nave, Gabriela Miss Mas, Pamela Lam Aguilar, Miguel Angel Soto Galindo
INTRODUCTION: Human milk immune components are unique and important for the development of the newborn. Milk processing at the Human Milk Banks (HMB), however, causes partial destruction of immune proteins. The objective of this study was to determine the effects that heating during the milk processing procedure at the HMB had on the concentrations of IgA, IgM, and lactoferrin at three critical points in time. MATERIALS AND METHODS: Fifty milk samples (150 mL) were collected from voluntary donors at the HMB at the Hospital Nacional Pedro de Bethancourt, located in Antigua Guatemala...
July 25, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28708126/the-effect-of-a-12-week-beta-hydroxy-beta-methylbutyrate-hmb-supplementation-on-highly-trained-combat-sports-athletes-a-randomised-double-blind-placebo-controlled-crossover-study
#2
Krzysztof Durkalec-Michalski, Jan Jeszka, Tomasz Podgórski
The aim of this study was to verify the effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on physical capacity, body composition and the value of biochemical parameters in highly-trained combat sports athletes. Forty-two males highly-trained in combat sports were subjected to 12 weeks of supplementation with HMB and a placebo in a randomized, placebo controlled, double-blind crossover manner. Over the course of the experiment, aerobic and anaerobic capacity was determined, while analyses were conducted on body composition and levels of creatine kinase, lactate dehydrogenase, testosterone, cortisol and lactate...
July 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28705993/effects-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-on-skeletal-muscle-mitochondrial-content-and-dynamics-and-lipids-after-10-days-of-bed-rest-in-older-adults
#3
Robert A Standley, Giovanna Distefano, Suzette L Pereira, Min Tian, Owen J Kelly, Paul M Coen, Nicolaas E P Deutz, Robert R Wolfe, Bret H Goodpaster
Loss of muscle mass during periods of disuse likely has negative health consequences for older adults. We have previously shown that β-hydroxy-β-methylbutyrate (HMB) supplementation during 10 days of strict bed rest (BR) attenuates the loss of lean mass in older adults. To elucidate potential molecular mechanisms of HMB effects on muscle during bed rest and resistance training rehabilitation (RT), we examined mediators of skeletal muscle mitochondrial dynamics, autophagy and atrophy, and intramyocellular lipids...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28696501/long-term-incidence-of-hysterectomy-following-endometrial-resection-or-endometrial-ablation-for-heavy-menstrual-bleeding
#4
Emmanouil Kalampokas, Sarah McRobbie, Fiona Payne, David E Parkin
OBJECTIVE: To estimate the incidence of hysterectomy following endometrial resection or endometrial ablation (ERA). METHODS: The present retrospective study enrolled women who underwent ERA for benign heavy menstrual bleeding (HMB) at Aberdeen Royal Infirmary, UK, between February 1, 1990, and December 31, 1997; follow-up data to the end of 2015 were included from the pathology laboratory report system from the single pathology laboratory in the region. Data were compared between patients who did or did not require a hysterectomy after ERA...
July 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28695686/imprint-cytology-of-clear-cell-sarcoma-like-tumor-of-the-gastrointestinal-tract-in-the-small-intestine-a-case-report
#5
Takashi Kato, Shin Ichihara, Hiroko Gotoda, Shunji Muraoka, Terufumi Kubo, Shintaro Sugita, Tadashi Hasegawa
Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) is an extremely rare malignant neoplasm in the digestive tract. Its cytomorphologic features have never previously been reported. Here, we describe a case of CCSLGT, including its cytologic examination findings. A 47-year-old woman presented with a mass in the small intestine, which was resected and sent for imprint cytology. Imprint smears revealed tumor cells with light eosinophilic or clear cytoplasm in a necrotic background. Many of the tumor cells were arranged in a perivascular growth with a pseudopapillary formation, and there were some non-neoplastic osteoclast-like giant cells...
July 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28691938/genetic-versus-epigenetic-brca1-silencing-pathways-clinical-effects-in-primary-ovarian-cancer-patients-a-study-of-the-tumor-bank-ovarian-cancer-consortium
#6
Tingting Sun, Ilary Ruscito, Desislava Dimitrova, Radoslav Chekerov, Hagen Kulbe, Udo Baron, Véronique Blanchard, Pierluigi Benedetti Panici, Silvia Darb-Esfahani, Jalid Sehouli, Sven Olek, Elena Ioana Braicu
OBJECTIVES: The aim of the present study was to assess in a large cohort of primary epithelial ovarian cancer patients the incidence and the clinical effect of BRCA1 genetic and epigenetic silencing mechanisms. METHODS: A total of 188 primary epithelial ovarian cancer patients, treated between 2000 and 2011 at the Charité University Hospital of Berlin, were included. The patients' tumor and blood samples were obtained from the Tumor Bank Ovarian Cancer Network (www...
July 6, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28683706/sarcopenia-what-should-a-pharmacist-know
#7
Alfonso J Cruz-Jentoft
Sarcopenia (or muscle insufficiency) is a geriatric syndrome characterized by a progressive and generalized loss of skeletal muscle mass and function which has adverse consequences, particularly physical disability, falls and death. It can develop slowly, as a chronic condition that emerges over many years, or acutely, generally due to immobilization associated with an acute disease. The physiopathology of sarcopenia is complex, and affects both the muscle and its neurological and hormonal regulation...
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28680453/discrepancies-in-publications-related-to-hmb-fa-and-atp-supplementation
#8
Jeremy A Gentles, Stuart M Phillips
This letter addresses a number of discrepancies found in several publications related HMB-FA and ATP supplementation.
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28678159/computational-investigation-into-the-interactions-of-traditional-chinese-medicine-molecules-of-wenqingyin-with-glur2
#9
Yu-Hui Tseng, Po-Hsiang Chuang, Yu-Ren Huang, Cheng-Lung Chen
Docking and molecular dynamics simulations have been carried out to investigate the interaction of a traditional Chinese medicine, WenQingYin, with the glutamate receptor 2 (GluR2) subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Four representative drug components of WenQingYin, namely 2-(3,4-dihydroxyphenyl)-5,6,7-trihydroxy-4H-chromen-4-one (PHF), 4-hydroxy-3-methoxybenzoic acid (HMB), 4-(2,3-dihydroxy-3-methylbutoxy)-7H-furo[3,2-g]chromen-7-one (DHMBP) and methyl 7-formylcyclopenta[c]pyran-4-carboxylate (cerbinal), and their complexes with GluR2 were simulated...
July 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28658849/renal-pelvis-leiomyoma-an-infrequent-clinical-case
#10
Fernando Ugarte-Y Romano, Adolfo González-Serrano, Jorge Moreno-Aranda
Renal pelvis leiomyomas are infrequent benign tumours. These tumours are more frequent in women, usually asymptomatic and difficult to distinguish from malign kidney masses. A 27-year-old female presented with an asymptomatic renal mass discovered after abdominal ultrasound during routine check-up. Percutaneous renal biopsy was performed and reported urothelial carcinoma. After open nephroureterectomy, histopathological evaluation and immunohistochemistry were positive for Smooth Muscle Actin (SMA), Ki67 <5%, and negative for cytokeratin and HMB-45...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658350/multifocal-oral-melanoacanthoma-associated-with-addison-s-disease-and-hyperthyroidism-a-case-report
#11
Thinali Sousa Dantas, Isabelly Vidal do Nascimento, Maria Elisa Quezado Lima Verde, Ana Paula Negreiros Nunes Alves, Fabrício Bitu Sousa, Mário Rogério Lima Mota
Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of multifocal oral melanoacanthoma in a patient diagnosed with Addison's disease and concomitant Graves' disease with hyperthyroidism. The patient presented with oral pigmented lesions, which were hypothesized to be mucosal pigmentation associated with Addison's disease. Due to their unusual clinical pattern, these oral lesions were biopsied and diagnosed as oral melanoacanthoma on histopathology and immunohistochemistry for HMB-45...
June 26, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28651949/%C3%AE-%C3%AE-t-cell-function-is-inhibited-in-end-stage-renal%C3%A2-disease-and-impacted-by-latent-tuberculosis%C3%A2-infection
#12
Jennifer A Juno, Jillian L M Waruk, Angela Harris, Christine Mesa, Carmen Lopez, Joe Bueti, T Blake Ball, Sandra A Kiazyk
Patients with end-stage renal disease (ESRD) are at elevated risk of acquiring infectious diseases, including tuberculosis (TB). Inflammation and uremia negatively impact immune function in this population, but specific pathways involved in TB immunity have not been identified. Although γδ T cells are known to contribute to protection from TB, their phenotype and function in patients with ESRD is relatively unknown. To determine this we recruited 20 patients with and 20 without ESRD (controls), with or without latent TB infection to assess γδ T cell frequency, surface phenotype, and cytokine production by flow cytometry in response to stimulation...
June 24, 2017: Kidney International
https://www.readbyqxmd.com/read/28643793/genomic-rearrangements-in-sporadic-lymphangioleiomyomatosis-an-evolving-genetic-story
#13
Stephen J Murphy, Simone B Terra, Faye R Harris, Aqsa Nasir, Jesse S Voss, James B Smadbeck, Sarah H Johnson, Vishnu Serla, Jay H Ryu, Eunhee S Yi, Benjamin R Kipp, George Vasmatzis, Eva M Carmona
Sporadic lymphangioleiomyomatosis is a progressive pulmonary cystic disease resulting from the infiltration of smooth muscle-like lymphangioleiomyomatosis cells into the lung. The migratory/metastasizing properties of the lymphangioleiomyomatosis cell together with the presence of somatic mutations, primarily in the tuberous sclerosis complex gene (TSC2), lead many to consider this a low-grade malignancy. As malignant tumors characteristically accumulate somatic structural variations, which have not been well studied in sporadic lymphangioleiomyomatosis, we utilized mate pair sequencing to define structural variations within laser capture microdissected enriched lymphangioleiomyomatosis cell populations from five sporadic lymphangioleiomyomatosis patients...
June 23, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28620396/identification-of-a-potential-isr-determinant-from-pseudomonas-aeruginosa-pm12-against-fusarium-wilt-in-tomato
#14
Sabin Fatima, Tehmina Anjum
Biocontrol of plant diseases through induction of systemic resistance is an environmental friendly substitute to chemicals in crop protection measures. Different biotic and abiotic elicitors can trigger the plant for induced resistance. Present study was designed to explore the potential of Pseudomonas aeruginosa PM12 in inducing systemic resistance in tomato against Fusarium wilt. Initially the bioactive compound, responsible for ISR, was separated and identified from extracellular filtrate of P. aeruginosa PM12...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28618723/evaluation-of-quality-of-life-and-cost-effectiveness-of-definitive-surgery-and-the-levonorgestrel-intrauterine-system-as-treatment-options-for-heavy-menstrual-bleeding
#15
Cevdet Adigüzel, Sevtap Seyfettinoğlu, Deniz Aka Satar, Sefa Arlier, Eda Eskimez, Fatma Kaya, Hakan Nazik
BACKGROUND/AIM: This study aimed to compare the levonorgestrel intrauterine system (LNG-IUS) with abdominal hysterectomy (TAH) and total laparoscopic hysterectomy (TLH) as first-line treatments for heavy menstrual bleeding (HMB). MATERIALS AND METHODS: Ninety-eight patients aged 20-55 years who complained of regular heavy menstrual bleeding were enrolled in the study. The TAH group included 29 patients, the LNG-IUS group included 34, and the TLH group included 35...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28617846/a-metabolite-of-leucine-%C3%AE-hydroxy-%C3%AE-methylbutyrate-given-to-sows-during-pregnancy-alters-bone-development-of-their-newborn-offspring-by-hormonal-modulation
#16
Tomasz Blicharski, Ewa Tomaszewska, Piotr Dobrowolski, Monika Hułas-Stasiak, Siemowit Muszyński
The effects of dietary β-hydroxy-β-methylbutyrate (HMB) supplementation during gestation on bone, growth plate, and articular cartilage in newborns were determined. Thermal analysis of articular cartilage was performed to examine the structural changes in collagen. At day 70 of gestation, a total of 12 sows (Large White Polish breed, at the second parity) were randomly assigned to two groups, with each group receiving either a basal diet or the same diet supplemented with 0.2 g/day HMB until the 90th day...
2017: PloS One
https://www.readbyqxmd.com/read/28609141/factor-11-single-nucleotide-variants-in-women-with-heavy-menstrual-bleeding
#17
Sophie Wiewel-Verschueren, André B Mulder, Karina Meijer, René Mulder
In a previous study it was shown that lower factor XI (FXI) levels in women with heavy menstrual bleeding (HMB). Our aim was to determine the single-nucleotide variants (SNVs) in the F11 gene in women with HMB. In addition, an extensive literature search was performed to determine the clinical significance of each SNV. Patients referred for HMB (PBAC-score >100) were included. With direct sequencing analysis of all 15 exons and flanking introns of the F11 gene, 29 different non-structural SNVs were detected in 49 patients with HMB...
June 13, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28599417/overexpression-of-the-anti-apoptotic-protein-bag3-in-human-choroidal-melanoma-a-case-report
#18
Tatsuya Yunoki, Yoshiaki Tabuchi, Takashi Kondo, Yoko Ishii, Atsushi Hayashi
Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), exerts anti-apoptotic effects in various malignant tumors. However, relationships between choroidal melanoma and BAG3 are poorly studied. This study investigated the expression of BAG3 in a case of human choroidal melanoma. Funduscopy, computed tomography, and single-photon emission computed tomography with the intravenous injection of N-isopropyl-p-[(123)I] iodoamphetamine strongly indicated choroidal melanoma in a 68-year-old woman...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28589627/benzothiazolium-single-crystals-a-new-class-of-nonlinear-optical-crystals-with-efficient-thz-wave-generation
#19
Seung-Heon Lee, Jian Lu, Seung-Jun Lee, Jae-Hyun Han, Chan-Uk Jeong, Seung-Chul Lee, Xian Li, Mojca Jazbinšek, Woojin Yoon, Hoseop Yun, Bong Joo Kang, Fabian Rotermund, Keith A Nelson, O-Pil Kwon
Highly efficient nonlinear optical organic crystals are very attractive for various photonic applications including terahertz (THz) wave generation. Up to now, only two classes of ionic crystals based on either pyridinium or quinolinium with extremely large macroscopic optical nonlinearity have been developed. This study reports on a new class of organic nonlinear optical crystals introducing electron-accepting benzothiazolium, which exhibit higher electron-withdrawing strength than pyridinium and quinolinium in benchmark crystals...
June 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28586411/incidence-and-treatment-of-heavy-menstrual-bleeding-in-general-practice
#20
Marian J van den Brink, Anne Linde Saaltink, Feikje Groenhof, Boudewijn J Kollen, Marjolein Y Berger, Yvonne Lisman-van Leeuwen, Janny H Dekker
Background.: Heavy menstrual bleeding (HMB) is a common problem in women of reproductive age. In 2008, the Dutch guideline for general practitioners (GPs) was revised to recommend the levonorgestrel intrauterine system (LNG-IUS) as a first-choice treatment for HMB. However, GP prescribing practices have not been studied in depth. Objectives.: To investigate the incidence and initial treatment of HMB in general practice, and to identify if there were changes in prescribing practices after the revision of the national guideline in 2008...
June 6, 2017: Family Practice
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