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Diabetes models

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https://www.readbyqxmd.com/read/28651396/-interaction-between-family-history-of-diabetes-and-hyperlipidemia-on-risk-of-diabetes-in-population-with-normotension-in-harbin-a-cross-sectional-study
#1
C D Bao, B Sun, L Lan, H Qiao, D F Zhang, X Y Liu, J Wang, Y S Zhao
Objective: To explore the interaction between family history of diabetes and hyperlipidemia on the risk of diabetes in population with normotension. Methods: A multistage stratified probability random sampling was conducted to select a representative sample of urban residents aged 20-74 years in Harbin. A total of 376 diabetes patients with normotension and 3 692 residents with normal blood pressure, normal fasting glucose, and normal 2 hours glucose from OGTT were surveyed. The interaction was evaluated by using crossover analysis and additive model...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651395/-analysis-of-dietary-pattern-and-diabetes-mellitus-influencing-factors-identified-by-classification-tree-model-in-adults-of-fujian
#2
F L Yu, Y Ye, Y S Yan
Objective: To find out the dietary patterns and explore the relationship between environmental factors (especially dietary patterns) and diabetes mellitus in the adults of Fujian. Methods: Multi-stage sampling method were used to survey residents aged ≥18 years by questionnaire, physical examination and laboratory detection in 10 disease surveillance points in Fujian. Factor analysis was used to identify the dietary patterns, while logistic regression model was applied to analyze relationship between dietary patterns and diabetes mellitus, and classification tree model was adopted to identify the influencing factors for diabetes mellitus...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651394/-relationship-between-sleep-status-and-the-risk-of-diabetes-in-adults
#3
J Su, R Tao, J Y Zhou, J Yang, Y Qin, Y H Hu, Y Lu, J R Jin, Z Bian, Y Guo, Z M Chen, L M Li, M Wu
Objective: To explore the relationship between sleep status and the risk of diabetes in adults. Methods: The baseline data of 53 260 subjects who were aged 30-79 years and had been enrolled into China Kadoorie Biobank (CKB) study from Suzhou, Jiangsu province were analyzed. Multiple logistic regression models were used to investigate the association between sleep status and diabetes after adjusting for potential confounders. Results: Among 53 260 subjects, 5.3% had diabetes. The proportions of difficultly falling asleep, early morning arousal and snoring frequently was 7...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651370/changes-in-visceral-adiposity-subcutaneous-adiposity-and-sex-hormones-in-the-diabetes-prevention-program
#4
Catherine Kim, Dana Dabelea, Rita R Kalyani, Costas A Christophi, George A Bray, Xavier Pi-Sunyer, Christine H Darwin, Swaytha Yalamanchi, Elizabeth Barrett-Connor, Sherita Hill Golden, Edward J Boyko
Context: The degree to which changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) relate to corresponding changes in plasma sex steroids is not known. Objective: We examined whether changes in VAT and SAT areas assessed by computed tomography were associated with changes in sex hormones (dehydroepiandrosterone [DHEAS], testosterone, estradiol, estrone, and sex hormone binding globulin [SHBG]) among Diabetes Prevention Program participants...
June 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28651212/ar-c-106t-gene-polymorphism-and-diabetic-nephropathy-in-the-eastern-asians-with-t2dm-a-meta-analysis-including-2120-subjects
#5
Yan-Yan Li, Hui Wang, Xin-Xing Yang, Hong-Yu Geng, Ge Gong, Xin-Zheng Lu
BACKGROUND: Aldose reductase (AR) gene C-106T polymorphism may be associated with diabetic nephropathy (DN) susceptibility, but the results of individual studies remain controversial. OBJECTIVE AND METHODS: To explore the relationship between AR gene C-106T gene polymorphism and DN in the Eastern Asians with type 2 diabetes mellitus (T2DM) population, we conducted a meta-analysis of 2120 participants from 5 studies. Pooled odds ratio (ORs) and the corresponding 95% confidence interval (95% CI) were evaluated by either a fixed or random-effects models...
June 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28650919/a-sudden-death-risk-score-specifically-for-hypertension-based-on-25%C3%A2-648-individual-patient-data-from-six-randomized-controlled-trials
#6
Hai-Ha Le, Fabien Subtil, Marc Cerou, Ivanny Marchant, Muaamar Al-Gobari, Mor Fall, Yanis Mimouni, Behrouz Kassaï, Lars Lindholm, Lutgarde Thijs, François Gueyffier
OBJECTIVE: To construct a sudden death risk score specifically for hypertension (HYSUD) patients with or without cardiovascular history. METHODS: Data were collected from six randomized controlled trials of antihypertensive treatments with 8044 women and 17 604 men differing in age ranges and blood pressure eligibility criteria. In total, 345 sudden deaths (1.35%) occurred during a mean follow-up of 5.16 years. Risk factors of sudden death were examined using a multivariable Cox proportional hazards model adjusted on trials...
June 24, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28650899/evaluation-of-a-digital-behavioral-counseling-program-for-reducing-risk-factors-for-chronic-disease-in-a-workforce
#7
Mark G Wilson, Cynthia M Castro Sweet, Michael D Edge, Erica N Madero, Megan McGuire, Megan Pilsmaker, Dan Carpenter, Scott Kirschner
OBJECTIVE: To evaluate a digitally delivered, intensive behavioral counseling program for a workforce at risk for obesity-related chronic disease. METHODS: Employees were offered a digital health program modeled after the diabetes prevention program (DPP). Annual workforce health assessments were used to examine changes in chronic disease risk factors between participants (n = 634) relative to a matched comparison group (n = 1268). RESULTS: Overall, employees were gaining an average of 3...
June 23, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28650409/platelet-rich-fibrin-accelerates-skin-wound-healing-in-diabetic-mice
#8
Yinjia Ding, Lei Cui, Qiming Zhao, Weiqiang Zhang, Huafeng Sun, Lijun Zheng
Diabetic foot ulcers (DFUs) are associated with an increased risk of secondary infection and amputation. Platelet-rich fibrin (PRF), a platelet and leukocyte concentrate containing several cytokines and growth factors, is known to promote wound healing. However, the effect of PRF on diabetic wound healing has not been adequately investigated. The aim of the study was to investigate the effect of PRF on skin wound healing in a diabetic mouse model. Platelet-rich fibrin was prepared from whole blood of 8 healthy volunteers...
June 23, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28650207/epicardial-pericardial-and-total-cardiac-fat-and-cardiovascular-disease-in-type-2-diabetic-patients-with-elevated-urinary-albumin-excretion-rate
#9
Regitse H Christensen, Bernt J von Scholten, Christian S Hansen, Sarah E Heywood, Jaya B Rosenmeier, Ulrik B Andersen, Peter Hovind, Henrik Reinhard, Hans-Henrik Parving, Bente K Pedersen, Marit E Jørgensen, Peter K Jacobsen, Peter Rossing
Background We evaluated the association of cardiac adipose tissue including epicardial adipose tissue and pericardial adipose tissue with incident cardiovascular disease and mortality, coronary artery calcium, carotid intima media thickness and inflammatory markers. Design A prospective study of 200 patients with type 2 diabetes and elevated urinary albumin excretion rate (UAER). Methods Cardiac adipose tissue was measured from baseline echocardiography. The composite endpoint comprised incident cardiovascular disease and all-cause mortality...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28649943/cost-effectiveness-of-insulin-detemir-versus-insulin-glargine-for-thai-type-2-diabetes-from-payer-s-perspective
#10
Unchalee Permsuwan, Kednapa Thavorn, Piyameth Dilokthornsakul, Surasak Saokaew, Nathorn Chaiyakunapruk
AIMS: An economic evidence is a vital tool that can inform the decision to use costly insulin analogues. This study aimed to evaluate long-term cost-effectiveness of insulin detemir (IDet) compared with insulin glargine (IGlar) in type 2 diabetes (T2DM) from the Thai payer's perspective. METHODS: Long-term costs and outcomes were projected using a validated IMS CORE Diabetes Model version 8.5. Cohort characteristics, baseline risk factors, and costs of diabetes complications were derived from Thai data sources...
June 26, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28649881/cost-effectiveness-analysis-of-insulin-degludec-compared-with-insulin-glargine-u100-for-the-management-of-type-1-and-type-2-diabetes-mellitus-from-the-spanish-national-health-system-perspective
#11
Pedro Mezquita-Raya, Josep Darba, Meritxell Ascanio, Antonio Ramírez de Arellano
AIMS: The objective of this study was to assess the cost-effectiveness of insulin degludec versus insulin glargine, from the Spanish NHS in three groups of patients. METHODS: A short-term cost utility model was developed to estimate effectiveness results in terms of the total number of hypoglycaemic events and their disutility impact throughout the year on the initial level of quality of life for patients in each treatment. RESULTS: Degludec was the dominant strategy for T2DM BOT and exhibited an incremental cost-effectiveness ratio of 52...
June 26, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28649880/understanding-type-1-diabetes-through-proteomics
#12
Inne Crèvecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh
Auto-immunity against pancreatic beta-cells leads to an absolute shortage of the hormone insulin, resulting in hyperglycemia and the onset of type 1 diabetes (T1D). Proteomic approaches have been used to elucidate the mechanisms of beta-cell dysfunction and death. Areas covered: In the present review, we discuss discoveries in the beta-cell proteome that have contributed to better insights in the role of the beta-cell in T1D. Techniques, such as 2D-DIGE and MALDI imaging, together with new approaches for sample preparation, including laser capture microdissection and immunopeptidomics, have resulted in novel mechanistic insights in the pathogenesis of T1D...
June 26, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28649865/dental-stem-cells-recent-progresses-in-tissue-engineering-and-regenerative-medicine
#13
João Botelho, Maria Alzira Cavacas, Vanessa Machado, José João Mendes
Since the disclosure of adult mesenchymal stem cells (MSCs) there have been an intense investigation on the characteristics of these cells and their potentialities. Dental Stem Cells (DSCs) are MSC-like populations with self-renewal capacity and multidifferentiation potential. Currently, there are five main DSCs, dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and Dental Follicle Precursor Cells (DFPCs)...
June 24, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28649577/in%C3%A2-vivo-murine-matured-human-cd3-cells-as-a-preclinical-model-for-t-cell-based-immunotherapies
#14
Kevin G Haworth, Christina Ironside, Zachary K Norgaard, Willimark M Obenza, Jennifer E Adair, Hans-Peter Kiem
Adoptive cellular immunotherapy is a promising and powerful method for the treatment of a broad range of malignant and infectious diseases. Although the concept of cellular immunotherapy was originally proposed in the 1990s, it has not seen successful clinical application until recent years. Despite significant progress in creating engineered receptors against both malignant and viral epitopes, no efficient preclinical animal models exist for rapidly testing and directly comparing these engineered receptors...
September 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28649285/introduction-of-the-diagene-study-clinical-characteristics-pathophysiology-and-determinants-of-vascular-complications-of-type-2-diabetes
#15
Thijs T W van Herpt, Roosmarijn F H Lemmers, Mandy van Hoek, Janneke G Langendonk, Ronald J Erdtsieck, Bert Bravenboer, Annelies Lucas, Monique T Mulder, Harm R Haak, Aloysius G Lieverse, Eric J G Sijbrands
BACKGROUND: Type 2 diabetes is a major healthcare problem. Glucose-, lipid-, and blood pressure-lowering strategies decrease the risk of micro- and macrovascular complications. However, a substantial residual risk remains. To unravel the etiology of type 2 diabetes and its complications, large-scale, well-phenotyped studies with prospective follow-up are needed. This is the goal of the DiaGene study. In this manuscript, we describe the design and baseline characteristics of the study...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28649241/insulin-modulates-cytokine-release-collagen-and-mucus-secretion-in-lung-remodeling-of-allergic-diabetic-mice
#16
Sabrina S Ferreira, Fernanda P B Nunes, Felipe B Casagrande, Joilson O Martins
INTRODUCTION: The role of insulin in lung remodeling in a model of asthma in healthy and diabetic mice was evaluated. MATERIAL AND METHODS: Diabetic male BALB/c mice (alloxan, 50 mg/kg, intravenous) and controls were sensitized by subcutaneous (s.c.) injection of ovalbumin (OA, 20 µg) in aluminum hydroxide (Al(OH)3, 2 mg) 10 days after the alloxan injection and received the same dose 12 days later. Six days after the last sensitization, animals were nebulized with OA solution for 7 days...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28648975/effect-of-extract-of-pueraria-tuberosa-on-expression-of-hypoxia-inducible-factor-1%C3%AE-and-vascular-endothelial-growth-factor-in-kidney-of-diabetic-rats
#17
Rashmi Shukla, Nidhi Pandey, Somanshu Banerjee, Yamini B Tripathi
BACKGROUNDS: Kidney hypoxia represents a unifying mechanism in the pathogenesis of diabetic nephropathy. Hypoxia-induced factor (HIF)-1α mediates the metabolic responses of renal hypoxia by modulating the expression of VEGF. In the present study, we investigated the effect of Pueraria tuberosa extract (PTY-2r) on the expression of HIF-1α, VEGF and nephrin in streptozotocin (STZ) induced diabetic nephropathy (DN). METHODS: The model of diabetic nephropathy (DN) was produced by intraperitoneal injection of 55mg/kg of STZ and maintained for 60days...
June 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28648963/the-association-between-diabetes-level-of-glycaemic-control-and-eye-infection-cohort-database-study
#18
Abdus Samad Ansari, Simon de Lusignan, William Hinton, Neil Munro, Andrew McGovern
AIM: To examine whether diabetes and the degree of glycaemic control is associated with an increased risk of acute eye infection, and prescribing of ocular antimicrobial agents. DESIGN AND SETTING: A retrospective cohort study was carried out using the Royal College of General Practitioners Research and Surveillance Centre database (RCGP RSC), a large primary care database in the United Kingdom. We compared ocular infection rates in people aged ≥15 years without diabetes to those with diabetes, both type 1 and type 2...
June 22, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28648855/decreasing-incidence-of-foot-ulcer-among-patients-with-type-1-and-type-2-diabetes-in-the-period-2001-2014
#19
A Rasmussen, T Almdal, A Anker Nielsen, K E Nielsen, M E Jørgensen, S Hangaard, V Siersma, P E Holstein
AIM: Diabetic foot ulcer (DFU) is a serious complication to diabetes. The aim was to study the incidence of first DFU among patients with type 1 (T1DM) and type 2 diabetes (T2DM), stratified according to etiology: neuropathic, neuro-ischemic or ischemic, over a period of 14years (2001-2014). METHODS: DFU incidence rates were calculated from electronic patient record data from patients with T1DM and complicated T2DM from a large specialized diabetes hospital with a multidisciplinary foot clinic in Denmark...
June 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28648854/is-there-a-burnt-out-diabetes-phenomenon-in-patients-on-hemodialysis
#20
Masanori Abe, Takayuki Hamano, Junichi Hoshino, Atsushi Wada, Masaaki Inaba, Shigeru Nakai, Ikuto Masakane
AIMS: In patients with diabetes on hemodialysis (HD), glycemic control improves spontaneously, leading to normal glycated hemoglobin (HbA1c) levels; this phenomenon is known as "burnt-out diabetes." However, glycated albumin (GA) might be a better indicator of glycemic control than HbA1c in HD patients. Therefore, the aim of this study was to identify how many patients experience "burnt-out diabetes" using HbA1c and GA levels and to examine the association between cardiovascular comorbidity risk and GA levels...
June 13, 2017: Diabetes Research and Clinical Practice
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