keyword
MENU ▼
Read by QxMD icon Read
search

Ear infections

keyword
https://www.readbyqxmd.com/read/27914361/development-of-cxcr4-modulators-by-virtual-hts-of-a-novel-amide-sulfamide-compound-library
#1
Renren Bai, Qi Shi, Zhongxing Liang, Younghyoun Yoon, Yiran Han, Amber Feng, Shuangping Liu, Yoonhyeun Oum, C Chris Yun, Hyunsuk Shim
CXCR4 plays a crucial role in recruitment of inflammatory cells to inflammation sites at the beginning of the disease process. Modulating CXCR4 functions presents a new avenue for anti-inflammatory strategies. However, using CXCR4 antagonists for a long term usage presents potential serious side effect due to their stem cell mobilizing property. We have been developing partial CXCR4 antagonists without such property. A new computer-aided drug design program, the FRESH workflow, was used for anti-CXCR4 lead compound discovery and optimization, which coupled both compound library building and CXCR4 docking screens in one campaign...
November 24, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27913719/surgical-site-infections-in-major-head-and-neck-surgeries-involving-pedicled-flap-reconstruction
#2
Neerav Goyal, Bharat B Yarlagadda, Daniel G Deschler, Kevin S Emerick, Derrick T Lin, Debbie L Rich, James W Rocco, Marlene L Durand
OBJECTIVE: To evaluate surgical site infections (SSI) after pedicled reconstruction in head and neck surgery. METHODS: Records of patients with pedicled flap reconstructions between 2009 and 2014 at Massachusetts Eye and Ear were reviewed. Onset of SSI or fistula ≤30 days postoperatively was noted. A free flap cohort was reviewed for comparison. RESULTS: Two hundred and eight pedicled reconstructions were performed for cancer (83%), osteoradionecrosis (7%), and other reasons (10%)...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27913087/a-case-of-multiple-empyema-caused-by-streptococcus-intermedius
#3
Akihito Kaga, Ryuzaburo Higo, Hiroshi Yoshikawa, Naoko Yokoi, Takuo Haruyama, Hiroaki Komatsu, Ayumi Yabe, Takeshi Kusunoki, Katsuhisa Ikeda
We report the case of a patient with multiple empyema present throughout his body, including chronic sinusitis and chronic suppurative otitis media, as well as subsequent epidural empyema, all caused by Streptococcus intermedius. A 38-year-old man presented with chief complaints of headache, left ear discharge, and nasal congestion. Imaging studies revealed pansinusitis, soft tissue signs in the mastoid cells, and otitis media. The patient was treated with meropenem hydrate, 6g/day. While clinical findings indicated improvement of the sinusitis, his headache did not improve...
November 29, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27895351/frequency-of-sensorineural-hearing-loss-in-chronic-suppurative-otitis-media
#4
Syed Sajjad Ali Zaidi, Hamdan Ahmed Pasha, Anwar Suhail, Talha Ahmed Qureshi
Chronic suppurative otitis media (CSOM) is defined as chronic otorrhea (i.e., lasting > 6-12 weeks) through a perforated tympanic membrane. It is generally associated with some degree of conductive hearing loss. However, recurrent ear infections due to perforated eardrum result in absorption of toxins and macromolecules into the cochlea leading to sensorineural hearing loss (SNHL). We planned to determine the frequency of sensorineural hearing loss in chronic suppurative otitis media. A descriptive cross-sectional study was conducted at Aga Kgan University Hospital, Karachi, from October 2013 to March 2014...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27895000/severe-acute-otitis-media-and-acute-mastoiditis-in-adults
#5
Anu Laulajainen Hongisto, Jussi Jero, Antti Markkola, Riste Saat, Antti A Aarnisalo
OBJECTIVE: To evaluate and compare clinical and microbiological findings in adults hospitalized for acute otitis media (AOM) or mastoid infections (acute or latent). MATERIALS AND METHODS: We retrospectively reviewed the medical records of all adults (≥17 years old) hospitalized (between 2003 and 2012) at a tertiary referral center for acute mastoid infections or AOM not responding to outpatient medical treatment. RESULTS: Of the 160 patients in the study sample, 19% had an infection caused by S...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27883914/association-of-outdoor-air-pollution-and-indoor-renovation-with-early-childhood-ear-infection-in-china
#6
Qihong Deng, Chan Lu, Wei Jiang, Jinping Zhao, Linjing Deng, Yuguang Xiang
BACKGROUND: Otitis media (OM) is a common infection in early childhood with repeated attacks that lead to long-term complications and sequelae, but its risk factors still remain unclear. OBJECTIVE: To examine the risk of childhood OM for different indoor and outdoor air pollutants during different timing windows, with a purpose to identify critical windows of exposure and key components of air pollution in the development of OM. METHODS: We conducted a retrospective cohort study of 1617 children aged 3-4 years in Changsha, China (2011-2012)...
November 21, 2016: Chemosphere
https://www.readbyqxmd.com/read/27880665/the-current-treatment-landscape-candidiasis
#7
Matteo Bassetti, Maddalena Peghin, Jean-Francois Timsit
The epidemiology of Candida species infection has changed over recent decades, influenced by local hospital-related factors, patient predisposing conditions and type of antifungal agents administered. A shift from Candida albicans as the predominant pathogen towards an increasing prevalence of the species Candida glabrata and Candida parapsilosis amongst critically ill patients has been documented. Changes in Candida species distribution may impact treatment recommendations due to differences in susceptibility to antifungal agents among species...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27880051/multimorbidities-of-asthma-allergies-and-airway-illnesses-in-childhood-chance-or-not-chance
#8
Wei Liu, Chen Huang, Xueying Wang, Jiao Cai, Yu Hu, Zhijun Zou, Louise B Weschler, Li Shen, Jan Sundell
OBJECTIVES: We investigated patterns of multimorbidities among asthma, allergies, and respiratory illnesses in preschool children. We examined lifetime multimorbidities of asthma, allergic rhinitis, eczema, food allergy, pneumonia, and ear infections; and current (in the last year before the survey) multimorbidities of wheeze, dry cough, rhinitis, eczema, and common cold during childhood. We further analyzed whether prevalences of these multimorbidities were due to chance. METHODS: A cross-sectional study was conducted in 72 kindergartens of Shanghai, China...
November 23, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27879228/identifying-the-optimal-water-occluding-earplugs-a-scientific-simulation-study
#9
Joshua Kovoor, Ali Al Hussaini, Steven Backhouse
OBJECTIVE: Numerous types of water-occluding earplugs are available as a means of preventing infection in patients with external and middle ear disease. However, little is known about the comparative efficacies of these earplugs with prolonged water exposure. In this study, we assessed the water impermeability of various earplug materials to prolonged water exposure. MATERIALS AND METHODS: Nine earplugs were tested: cotton wool mixed with petroleum jelly, cotton wool externally coated with petroleum jelly, Blu-Tack, foam earplugs, silicone putty, silicone earplugs, flanged earplugs, and hard and soft silicone custom-moulds...
November 23, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27878589/chronological-changes-in-microbial-profiles-in-external-and-middle-ear-diseases-a-20-year-study-in-korea
#10
Hantai Kim, Oak-Sung Choo, Jeong Hun Jang, Hun Yi Park, Yun-Hoon Choung
Microbial infection is one of the most significant causes of ear diseases, but microbial profiles are very diverse according to the diseases and change over time. The purpose of the study was to clarify differences and chronological changes in causative pathogens among infectious ear diseases over the last 20 years, and to identify antibiotic resistance. In total, 1191 isolates were included from patients diagnosed with chronic otitis media without cholesteatoma (COM), cholesteatomatous otitis media (Chole), middle ear effusion (MEE), including acute otitis media and otitis media with effusion, and external otitis (EO)...
November 23, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27876947/a-survey-on-parasites-of-long-eared-hedgehog-hemiechinus-auritus-in-northeast-of-iran
#11
Ali Moshaverinia, Hassan Borji, Mehrab Kameli, Sara Ghabdian, Reza Ghanei
As there appeared to be no data available on parasite infection of Hedgehogs in the region and considering the potential threat of Hedgehogs for animal and public health, the present study was carried out using biological samples and necropsy findings collected from long-eared hedgehog captured in Mashhad city in the northeast of Iran. During the study 23 dead hedgehogs were collected randomly from different regions of Mashhad County. Following autopsy of these animals, observation for enteric parasites was carefully done...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27875026/disseminated-bcg-pneumonitis-revealing-severe-combined-immunodeficiencyxs-in-charge-syndrome
#12
Hyung Young Kim, Yoo-Mi Kim, Hee Ju Park
CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, and ear anomalies/deafness) syndrome is a rare genetic disorder caused by CHD7 mutation and is related to immunodeficiency. A 6-month-old girl with right lung agenesis, congenital heart defects, and ear anomalies developed repeated and serious respiratory infection for a short period. She was clinically diagnosed with typical CHARGE syndrome with severe combined immunodeficiency (T-, B+, NK-); however, CHD7 mutation was not detected...
November 22, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27871222/genome-wide-association-study-gwas-reveals-the-genetic-architecture-of-four-husk-traits-in-maize
#13
Zhenhai Cui, Jinhong Luo, Chuangye Qi, Yanye Ruan, Jing Li, Ao Zhang, Xiaohong Yang, Yan He
BACKGROUND: Maize (Zea mays) husk referring to the leafy outer enclosing the ear, plays an important role in grain production by directly contributing photosynthate and protecting ear from pathogen infection. Although the physiological functions related to husk have been extensively studied, little is known about its morphological variation and genetic basis in natural population. RESULTS: Here we utilized a maize association panel including 508 inbred lines with tropical, subtropical and temperate backgrounds to decipher the genetic architecture attributed to four husk traits, i...
November 21, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27867390/the-mechanisms-of-maize-resistance-to-fusarium-verticillioides-by-comprehensive-analysis-of-rna-seq-data
#14
Yanping Wang, Zijian Zhou, Jingyang Gao, Yabin Wu, Zongliang Xia, Huiyong Zhang, Jianyu Wu
Fusarium verticillioides is the most commonly reported fungal species responsible for ear rot of maize which substantially reduces grain yield. It also results in a substantial accumulation of mycotoxins that give rise to toxic response when ingested by animals and humans. For inefficient control by chemical and agronomic measures, it thus becomes more desirable to select more resistant varieties. However, the molecular mechanisms underlying the infection process remain poorly understood, which hampers the application of quantitative resistance in breeding programs...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27865940/alterations-in-nasal-mucociliary-activity-in-polycystic-ovary-syndrome
#15
Suna Kabil Kucur, Ali Seven, Beril Yuksel, Cuneyt Kucur, Halime Sencan, Ilay Gozukara, Nadi Keskin
OBJECTIVES: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. It can affect various organ systems, and respiratory mucosa has been reported as being hormone responsive. STUDY DESIGN: A case-control study consisting of 50 women with PCOS and 30 control subjects matched for age and body mass index was conducted, in order to investigate nasal mucociliary clearance time (NMCT) in patients with PCOS. Serum basal hormonal-biochemical parameters and NMCT were evaluated on menstrual cycle days 2-5 for all participants...
October 26, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27865535/intratympanic-methylprednisolone-versus-gentamicin-in-patients-with-unilateral-m%C3%A3-ni%C3%A3-re-s-disease-a-randomised-double-blind-comparative-effectiveness-trial
#16
Mitesh Patel, Kiran Agarwal, Qadeer Arshad, Mohamed Hariri, Peter Rea, Barry M Seemungal, John F Golding, Jonny P Harcourt, Adolfo M Bronstein
BACKGROUND: Ménière's disease is characterised by severe vertigo attacks and hearing loss. Intratympanic gentamicin, the standard treatment for refractory Ménière's disease, reduces vertigo, but damages vestibular function and can worsen hearing. We aimed to assess whether intratympanic administration of the corticosteroid methylprednisolone reduces vertigo compared with gentamicin. METHODS: In this double-blind comparative effectiveness trial, patients aged 18-70 years with refractory unilateral Ménière's disease were enrolled at Charing Cross Hospital (London, UK) and Leicester Royal Infirmary (Leicester, UK)...
November 16, 2016: Lancet
https://www.readbyqxmd.com/read/27833862/otological-manifestations-of-nonseptic-lateral-sinus-thrombosis-a-review
#17
M S Vijayashree, B Viswanatha
Nonseptic lateral sinus thrombosis differs from septic lateral sinus thrombosis in that it is not associated with ear or sinus infection. Etiologies of these conditions are different and management of these conditions are different. Nonseptic lateral sinus thrombosis requires medical line of management and anticoagulant therapy where as septic lateral sinus thrombosis treatment involves surgical exploration of the mastoid cavity, sinus decompression, and long-term antibiotic therapy. Mastoid changes are frequently detected on computed tomography or magnetic resonance imaging in cases of nonseptic lateral sinus thrombosis...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27832049/investigation-of-the-first-seven-reported-cases-of-candida-auris-a-globally-emerging-invasive-multidrug-resistant-fungus-united-states-may-2013-august-2016
#18
Snigdha Vallabhaneni, Alex Kallen, Sharon Tsay, Nancy Chow, Rory Welsh, Janna Kerins, Sarah K Kemble, Massimo Pacilli, Stephanie R Black, Emily Landon, Jessica Ridgway, Tara N Palmore, Adrian Zelzany, Eleanor H Adams, Monica Quinn, Sudha Chaturvedi, Jane Greenko, Rafael Fernandez, Karen Southwick, E Yoko Furuya, David P Calfee, Camille Hamula, Gopi Patel, Patricia Barrett, Patricia Lafaro, Elizabeth L Berkow, Heather Moulton-Meissner, Judith Noble-Wang, Ryan P Fagan, Brendan R Jackson, Shawn R Lockhart, Anastasia P Litvintseva, Tom M Chiller
Candida auris, an emerging fungus that can cause invasive infections, is associated with high mortality and is often resistant to multiple antifungal drugs. C. auris was first described in 2009 after being isolated from external ear canal discharge of a patient in Japan (1). Since then, reports of C. auris infections, including bloodstream infections, have been published from several countries, including Colombia, India, Israel, Kenya, Kuwait, Pakistan, South Africa, South Korea, Venezuela, and the United Kingdom (2-7)...
November 11, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27822233/molecular-characterization-and-phylogenetic-analysis-of-bovine-viral-diarrhea-virus-in-dairy-herds-of-fars-province-iran
#19
A Khodakaram-Tafti, A Mohammadi, G H Farjani Kish
Bovine viral diarrhea virus (BVDV) is one of the most important viral pathogens of cattle worldwide. The aim of present study was to determine the molecular characterization and phylogenetic analysis of BVDV infection in dairy herds of Fars province, Iran. For initial screening, a total of 400 blood samples were collected from 12 industrial dairy herds with previous history of diarrhea, abortion or birth of weak calves and analyzed using reverse transcription-polymerase chain reaction (RT-PCR) on buffy coat...
2016: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/27813123/determination-of-nasal-mucociliary-clearance-time-and-nasal-symptom-in-patients-with-crimean-congo-hemorrhagic-fever
#20
Kasım Durmuş, Aynur Engin, Tuba Doğan Karataş, Mustafa Gökhan Gözel, Emine Elif Altuntas
Crimean-Congo hemorrhagic fever (CCHF) is an important health problem in Turkey. Number of studies on symptoms of ear nose throat system and indicating whether or not the organs are affected in patients with CCHF is limited. The aim of the present study was to investigate whether CCHF infections caused any change in nasal physiology in adult patients or not by using saccharin transit time (STT) and nasal symptom scoring. Twenty subjects with laboratory-confirmed diagnosis of CCHF and 28 healthy control subjects were included in the present study...
November 3, 2016: Journal of Medical Virology
keyword
keyword
15166
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"