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https://www.readbyqxmd.com/read/28534037/otogenic-meningitis-a-comparison-of-diagnostic-performance-of-surgery-and-radiology
#1
Luca Bruschini, Simona Fortunato, Carlo Tascini, Annalisa Ciabotti, Alessandro Leonildi, Belinda Bini, Simone Giuliano, Arturo Abbruzzese, Stefano Berrettini, Francesco Menichetti
Development of intracranial complications from middle ear infections might be difficult to diagnose. We compared radiological and surgical findings of 26 patients affected by otogenic meningitis. Results of our analysis showed that surgery is more reliable than imaging in revealing bone defects. Therefore, suggest that surgery be performed for diagnosis and eventual management of all cases of suspected otogenic meningitis.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28526836/characterisation-of-antibiotic-prescriptions-for-acute-respiratory-tract-infections-in-danish-general-practice-a-retrospective-registry-based-cohort-study
#2
Rune Aabenhus, Malene Plejdrup Hansen, Laura Trolle Saust, Lars Bjerrum
Inappropriate use of antibiotics is contributing to the increasing rates of antimicrobial resistance. Several Danish guidelines on antibiotic prescribing for acute respiratory tract infections in general practice have been issued to promote rational prescribing of antibiotics, however it is unclear if these recommendations are followed. We aimed to characterise the pattern of antibiotic prescriptions for patients diagnosed with acute respiratory tract infections, by means of electronic prescriptions, labeled with clinical indications, from Danish general practice...
May 19, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28526427/atypical-presentations-of-cutaneous-leishmaniasis-a-systematic-review
#3
REVIEW
Camilla Barros Meireles, Laís Chaves Maia, Gustavo Coelho Soares, Ilara Parente Pinheiro Teodoro, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva, Marcos Antonio Pereira de Lima
Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. The search terms browsed were "cutaneous leishmaniasis", "atypical" and "unusual". Based on the eligibility criteria, 34 out of 122 articles were included in the final sample...
May 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28526177/two-cell-populations-participate-in-clearance-of-damaged-hair-cells-from-the-sensory-epithelia-of-the-inner-ear
#4
REVIEW
Keiko Hirose, Mark A Rutherford, Mark E Warchol
The cochlea and the vestibular organs are populated by resident macrophages, but their role in inner ear maintenance and pathology is not entirely clear. Resident macrophages in other organs are responsible for phagocytosis of injured or infected cells, and it is likely that macrophages in the inner ear serve a similar role. Hair cell injury causes macrophages to accumulate within proximity of damaged regions of the inner ear, either by exiting the vasculature and entering the labyrinth or by the resident macrophages reorganizing themselves through local movement to the areas of injury...
April 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/28515218/group-b-streptococcus-among-pregnant-women-and-newborns-in-mirzapur-bangladesh-colonization-vertical-transmission-and-serotype-distribution
#5
Samir K Saha, Zabed B Ahmed, Joyanta K Modak, Hakka Naziat, Shampa Saha, Mohammad A Uddin, Maksuda Islam, Abdullah H Baqui, Gary L Darmstadt, Stephanie J Schrag
Group B Streptococcus (GBS) infection is a leading cause of death in newborns in developed countries. Data on burden of GBS in Asian countries is lacking. This study aimed to understand i) rate of maternal recto-vaginal GBS carriage, ii) vertical transmission of GBS as determined by culturing ear, umbilicus and nasal swabs, and iii) distribution of GBS serotypes. This prospective observational study was conducted from September 2012 to November 2013 at Kumudini Hospital, a secondary level hospital, at Mirzapur, Bangladesh...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28509140/a-rare-adult-case-of-poststreptococcal-acute-glomerulonephritis-with-a-retropharyngeal-abscess
#6
Tsuyoshi Takashima, Sae Hirata, Mai Nonaka, Keiichiro Matsumoto, Yuki Awanami, Masatora Yamasaki, Makoto Fukuda, Motoaki Miyazono, Yuji Ikeda
Retropharyngeal abscess is an infection involving the retropharyngeal space which is posterior to the pharynx and oesophagus, and it results as a complication of a primary infection elsewhere in the head and neck including the nasopharynx, paranasal sinuses, or middle ear, which drain lymph to the retropharyngeal lymph nodes. Their lymph nodes are prominent in children and atrophy with age. Therefore, retropharyngeal abscess is most frequently encountered in children, with 75% of cases occurring before the age of 5 years, and often in the first year of life...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28508096/-off-label-biologic-therapy-of-anca-associated-and-non-anca-associated-small-vessel-vasculitis-efficacy-and-safety-analysis-of-a-national-registry-graid2
#7
N Venhoff, F Proft, H Schulze-Koops, J Holle, R E Voll, C Iking-Konert, A M Jacobi, J Henes, L Unger, O Kneitz, T Dörner, J Thiel
OBJECTIVE: To evaluate the clinical efficacy and safety of off-label biological therapies in patients with ANCA-associated vasculitis (AAV) and non-ANCA-associated small-vessel vasculitis (nAAV) in clinical practice. METHODS: The German Registry in Autoimmune Diseases 2 (GRAID2) is a national, retrospective, non-interventional, multicentre observational study (August 2006 until December 2013) on patients with autoimmune diseases refractory to standard immunosuppressive therapy treated with off-label biologicals...
May 15, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28506250/antimicrobial-resistance-profile-of-staphylococcus-aureus-isolates-isolated-from-ear-discharges-of-patients-at-university-of-hawassa-comprehensive-specialized-hospital
#8
Serawit Deyno, Alemayehu Toma, Mesfin Worku, Muluken Bekele
BACKGROUND: Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a challenge. Studies assessing pattern and determinants of S. aureus resistance in ear infection in Ethiopia are very scarce. This study presents overview of pattern and determinants S. aureus resistance from samples of ear discharge in Ethiopia. METHOD: A prospective cross-sectional study was conducted on patients who visit ENT clinic of University of Hawassa comprehensive specialized hospital from February 1, 2016 to November 1, 2016...
May 15, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28503132/protecting-mammalian-hair-cells-from-aminoglycoside-toxicity-assessing-phenoxybenzamine-s-potential
#9
Paromita Majumder, Paulette A Moore, Guy P Richardson, Jonathan E Gale
Aminoglycosides (AGs) are widely used antibiotics because of their low cost and high efficacy against gram-negative bacterial infection. However, AGs are ototoxic, causing the death of sensory hair cells in the inner ear. Strategies aimed at developing or discovering agents that protect against aminoglycoside ototoxicity have focused on inhibiting apoptosis or more recently, on preventing antibiotic uptake by the hair cells. Recent screens for ototoprotective compounds using the larval zebrafish lateral line identified phenoxybenzamine as a potential protectant for aminoglycoside-induced hair cell death...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28500043/potential-for-water-borne-and-invertebrate-transmission-of-west-nile-virus-in-the-great-salt-lake-utah
#10
Melissa Lund, Valerie Shearn-Bochsler, Robert J Dusek, Jan Shivers, Erik Hofmeister
In November and December of 2013, a large mortality event involving 15,000 - 20,000 eared grebes (Podiceps nigricollis) occurred at the Great Salt Lake (GSL), UT. The onset of the outbreak in grebes was followed by a mortality event in > 86 bald eagles (Haliaeetus leucocephalus). During the die-off, West Nile virus (WNV) was detected by RT-PCR or viral culture in carcasses of grebes and eagles submitted to the National Wildlife Health Center. However, no mosquito activity, the primary vector of WNV, was detected by the State of Utah's WNV monitoring program...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28498895/acute-illness-among-surfers-after-exposure-to-seawater-in-dry-and-wet-weather-conditions
#11
Benjamin F Arnold, Kenneth C Schiff, Ayse Ercumen, Jade Benjamin-Chung, Joshua A Steele, John F Griffith, Steven J Steinberg, Paul Smith, Charles D McGee, Richard Wilson, Chad Nelsen, Stephen B Weisberg, John M Colford
Rainstorms increase levels of fecal indicator bacteria in urban coastal waters, but it is unknown whether exposure to seawater after rainstorms increases rates of acute illness. Our objective was to provide the first estimates of rates of acute illness after seawater exposure during both dry- and wet-weather periods and to determine the relationship between levels of indicator bacteria and illness among surfers, a population with a high potential for exposure after rain. We enrolled 654 surfers in San Diego, California, and followed them longitudinally during the 2013-2014 and 2014-2015 winters (33,377 days of observation, 10,081 surf sessions)...
May 11, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28495389/clinical-trainees-responses-to-parents-who-question-evidence-based-recommendations
#12
Sydney E Philpott, Holly O Witteman, Katherine M Jones, David S Sonderman, Anne-Sophie Julien, Mary C Politi
OBJECTIVE: We examined clinicians' attitudes, beliefs, and behavioral intentions about discussing evidence and eliciting values when patients question recommendations. METHODS: We randomized trainees to read one of three scenarios about a parent of a one-year-old: 1) overuse (parent requests antibiotics for presumed viral infection); 2) equipoise (tubes for recurrent ear infections); 3) underuse (parent hesitates about vaccination). Participants then answered survey questions...
May 2, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28490586/deletion-of-the-k1l-gene-results-in-a-vaccinia-virus-that-is-less-pathogenic-due-to-muted-innate-immune-responses-yet-still-elicits-protective-immunity
#13
Ariana G Bravo Cruz, Aiguo Han, Edward J Roy, Arielle B Guzmán, Rita J Miller, Elizabeth A Driskell, William D O'Brien, Joanna L Shisler
All viruses strategically alter the anti-viral immune response to their benefit. The vaccinia virus (VACV) K1 protein has multiple immunomodulatory effects in tissue culture models of infection, including NF-κB antagonism. However, the effect of K1 during animal infection is poorly understood. We determined that a K1L-less vaccinia virus (vΔK1L) was less pathogenic than wild-type VACV in intranasal and intradermal models of infection. Decreased pathogenicity correlated with diminished virus replication in intranasally-infected mice...
May 10, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28487811/curcumin-inhibits-nthi-induced-muc5ac-mucin-overproduction-in-otitis-media-via-upregulation-of-mapk-phosphatase-mkp-1
#14
Anuhya Sharma Konduru, Shingo Matsuyama, Byung-Cheol Lee, Kensei Komatsu, Jian-Dong Li
Otitis media (OM), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection. Nontypeable Haemophilus influenzae (NTHi) pathogen is responsible for approximately one-third of episodes of bacteria-caused OM. Current treatments for bacterial OM rely on the systemic use of antibiotics, which often leads to the emergence of multidrug resistant bacterial strains. Therefore there is an urgent need for developing alternative therapies strategies for controlling mucus overproduction in OM...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28487802/clinical-challenges-in-the-diagnosis-and-treatment-of-temporal-bone-osteomyelitis
#15
Liubov Kornilenko, Saulius Rocka, Svajunas Balseris, Irina Arechvo
Temporal bone osteomyelitis is a serious life-threatening condition-a quick and proper diagnosis is needed to start treatment and reduce morbidity and mortality. Changing trends of the disease make a differential diagnosis difficult. To emphasize the importance of a clinical suspicion of this dangerous condition, our experience with three difficult cases is presented. The diagnosis was based on clinical symptoms, otoscopic findings, and findings on computed tomography or magnetic resonance imaging. Neoplasm and granulomatous inflammation were excluded by multiple biopsies...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28485286/assesment-effectiveness-of-treatment-eustachian-tube-dysfunction-using-pneumatic-inhaler-amsa
#16
Iwona Zając-Ratajczak, Agata Szkiełkowska, Karina Wilhelmsen
INTRODUCTION: Upper respiratory tract infections are common childhood diseases. Children are more susceptible to middle ear infections because their Eustachian tube is short, straight and wide. As a consequence of these inflammatory changes while impaired patency of the Eustachian tube often arises conductive hearing. OBJECTIVE: The aim of this study was to Assessment effectiveness of treatment Eustachian tube dysfunction using inhaler AMSA. MATERIAL AND METHODS: The study group comprised 30 patients...
November 20, 2016: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28483256/infectious-complications-of-pediatric-cochlear-implants-are-highly-influenced-by-otitis-media
#17
Peter M Vila, Nsangou T Ghogomu, Audrey R Odom-John, Timothy E Hullar, Keiko Hirose
OBJECTIVE: Determine the incidence of ear infections in cochlear implant patients, evaluate the contribution of otitis media to complications, describe the bacteriology of otitis media in the cochlear implant population, the treatment provided at our center, and the long term outcome. METHODS: Data collected included age at implantation, history of otitis media or ear tubes, etiology of hearing loss, inner ear anatomy, postoperative infections, time to infection, route of antibiotic administration, and interventions for infections...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28482536/influences-of-mesoporous-zinc-calcium-silicate-on-water-absorption-degradability-antibacterial-efficacy-hemostatic-performances-and-cell-viability-to-microporous-starch-based-hemostat
#18
Yu Hou, Yan Xia, Yongkang Pan, Songchao Tang, Xiaofei Sun, Yang Xie, Han Guo, Jie Wei
Efficacious hemostatic agents have significant potential application in visceral organ or large vessel arterial injure. In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content. Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28479241/ototoxicity-of-boric-acid-powder-in-a-rat-animal-model
#19
Murat Salihoglu, Salim Dogru, Enver Cesmeci, Halil Caliskan, Onuralp Kurt, Zafer Kuçukodaci, Atila Gungor
INTRODUCTION: Boric acid, which has antiseptic and acidic properties, is used to treat external and middle ear infections. However, we have not found any literature about the effect of boric acid powder on middle ear mucosa and inner ear. OBJECTIVE: The purpose of this study is to investigate possible ototoxic effects of boric acid powder (BAP) on cochlear outer hair cell function and histological changes in middle ear mucosa in a rat animal model. METHODS: Twenty healthy, mature Wistar albino rats were used in this study...
April 22, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28478966/a-rare-case-of-multiple-brain-abscess-and-probably-disseminated-phaeohyphomycosis-due-to-cladophialophora-bantiana-in-an-immunosuppressed-individual-from-india
#20
S Lahiri Mukhopadhyay, A Mahadevan, V H Bahubali, R Dawn Bharath, A R Prabhuraj, S Maji, N Siddaiah
Cladophialophora bantiana, a dematiaceous neurotropic mold causes rare and lethal brain abscess, commonly in immunocompetent hosts. We report a rare and probably a case of disseminated infection with this black mold in an immunosuppressed individual from India. A 55-year-old diabetic male presented with severe headache, blurred-vision, behavioural abnormalities, eye-pain and ear-discharge. He was undergoing treatment for hypertension, prostatomegaly and obstructive pulmonary disease. He was on steroids for the past six years for uveitis...
May 3, 2017: Journal de Mycologie Médicale
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