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Cardiovascular MRI

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https://www.readbyqxmd.com/read/29907089/temporarily-increased-stroke-rate-after-takotsubo-syndrome-need-for-an-anticoagulation
#1
Nadine Abanador-Kamper, Lars Kamper, Judith Wolfertz, Marc Vorpahl, Patrick Haage, Melchior Seyfarth
BACKGROUND: Previous studies have reported slightly higher stroke rates in Takotsubo Syndrome compared to acute myocardial infarction. Our goal was to evaluate the temporal course of stroke rates and left ventricular recovery in patients with Takotsubo Syndrome. METHODS: We retrospectively examined the clinical and imaging data of 72 patients with Takotsubo Syndrome. The data collected came from January 2005 to March 2017. Left ventricular performance was evaluated by cardiovascular magnetic resonance imaging (MRI) in all patients during the acute phase of Takotsubo Syndrome and in a follow-up scan 2 months later...
June 15, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29904830/migraine-and-cerebrovascular-disease-still-a-dangerous-connection
#2
Elio Clemente Agostoni, Marco Longoni
Migraine is a common type of headache in young adults, with an estimated prevalence of 4% before puberty and as high as 25% in women by their mid to late 30s. About one third of migraineurs experience transient neurological symptoms known as auras, which characterize a variant known as migraine with aura. Many evidences have shown an increased risk of vascular events in patients affected by migraine, particularly among women and among migraine patients with aura. Potential underlying mechanisms include endothelial dysfunction, hypercoagulability, platelet aggregation, vasospasm, cardiovascular risk factors, paradoxical embolism, spreading depolarization, shared genetic risk, use of non-steroidal anti-inflammatory drugs, and immobilization...
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29898969/increased-caide-dementia-risk-cognition-csf-biomarkers-and-vascular-burden-in-healthy-adults
#3
Mirian Ecay-Torres, Ainara Estanga, Mikel Tainta, Andrea Izagirre, Maite Garcia-Sebastian, Jorge Villanua, Montserrat Clerigue, Ane Iriondo, Iratxe Urreta, Arantzazu Arrospide, Carmen Díaz-Mardomingo, Miia Kivipelto, Pablo Martinez-Lage
OBJECTIVE: To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. METHOD: Cognitively normal participants (mean age 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR; n = 82) or low risk (LR; n = 293) for dementia according to a CAIDE score cutoff of 9...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29896107/construction-and-validation-of-subject-specific-biventricular-finite-element-models-of-healthy-and-failing-swine-hearts-from-high-resolution-dt-mri
#4
Kevin L Sack, Eric Aliotta, Daniel B Ennis, Jenny S Choy, Ghassan S Kassab, Julius M Guccione, Thomas Franz
Predictive computational modeling has revolutionized classical engineering disciplines and is in the process of transforming cardiovascular research. This is particularly relevant for investigating emergent therapies for heart failure, which remains a leading cause of death globally. The creation of subject-specific biventricular computational cardiac models has been a long-term endeavor within the biomedical engineering community. Using high resolution (0.3 × 0.3 × 0.8 mm) ex vivo data, we constructed a precise fully subject-specific biventricular finite-element model of healthy and failing swine hearts...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29895299/association-between-abdominal-adiposity-and-subclinical-measures-of-left-ventricular-remodeling-in-diabetics-prediabetics-and-normal-controls-without-history-of-cardiovascular-disease-as-measured-by-magnetic-resonance-imaging-results-from-the-kora-ff4-study
#5
Christopher L Schlett, Roberto Lorbeer, Carolyn Arndt, Sigrid Auweter, Jürgen Machann, Holger Hetterich, Birgit Linkohr, Wolfgang Rathmann, Annette Peters, Fabian Bamberg
OBJECTIVES: Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states. METHODS: Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI...
June 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29874201/effect-of-lactobacillus-rhamnosus-gg-supplementation-on-intestinal-inflammation-assessed-by-pet-mri-scans-and-gut-microbiota-composition-in-hiv-infected-individuals
#6
Caroline J Arnbjerg, Beate Vestad, Johannes R Hov, Karin K Pedersen, Sofie Jespersen, Helle H Johannesen, Kristian Holm, Bente Halvorsen, Eva Fallentin, Adam E Hansen, Theis Lange, Andreas Kjær, Marius Trøseid, Barbara M Fischer, Susanne D Nielsen
BACKGROUND: Alterations in gut microbiome have been associated with inflammation and increased cardiovascular risk in HIV-infected individuals. The aim of this study was to investigate effects of the probiotic strain Lactobacillus rhamnosus GG (LGG) on intestinal inflammation, gut microbiota composition and systemic markers of microbial translocation and inflammation in HIV-infected individuals. METHODS: This prospective, clinical interventional trial included 45 individuals (15 cART-naïve and 30 cART-treated) that ingested LGG twice daily at a dosage of 6 x109 colony-forming units per capsule for a period of eight weeks...
March 29, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29872089/ccl2-deficiency-protects-against-chronic-renal-injury-in-murine-renovascular-hypertension
#7
Sonu Kashyap, Mazen Osman, Christopher M Ferguson, Meryl C Nath, Bhaskar Roy, Karen R Lien, Karl A Nath, Vesna D Garovic, Lilach O Lerman, Joseph P Grande
Inflammation plays an important role in the pathogenesis of renal and cardiovascular disease in renovascular hypertension (RVH). Ccl2 is an important mediator of inflammation, and is induced within 24 hours following surgery to establish RVH in the murine 2 kidney 1 clip model, a time prior to onset of interstitial inflammation, fibrosis, or tubular atrophy. We tested the hypothesis that Ccl2 deficiency protects the stenotic kidney (STK) from development of chronic renal damage in mice with renovascular hypertension due to renal artery stenosis (RAS)...
June 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29870977/association-of-intradialytic-hypertension-with-left-ventricular-mass-in-hypertensive-hemodialysis-patients-enrolled-in-the-blood-pressure-in-dialysis-bid-study
#8
Amith Roy Shamir, Ameet Karembelkar, Jonathan Yabes, Yi Yao, Dana Miskulin, Jennifer Gassman, David Ploth, Lavinia Negrea, Susan Paine, Mahboob Rahman, Raymond Y Kwong, Philip Zager, Manisha Jhamb
BACKGROUND/AIMS: Intradialytic hypertension (IDH), or paradoxical rise in blood pressure (BP) during hemodialysis (HD) is associated with increased morbidity and mortality. The association between IDH and increased left ventricular mass (LVM), a well-known risk factor for adverse cardiovascular outcomes in HD patients, has not been studied. The aim of our study is to evaluate the cross-sectional association of intradialytic change in BP with cardiac structure and function measured by cardiac MRI in hypertensive HD patients enrolled in the multi-center Blood Pressure in Dialysis (BID) clinical trial...
May 30, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29869959/fractal-analysis-of-right-ventricular-trabeculae-in-pulmonary-hypertension
#9
Timothy J W Dawes, Jiashen Cai, Marina Quinlan, Antonio de Marvao, Philip J Ostrowski, Paweł F Tokarczuk, Geoffrey M J Watson, John Wharton, Luke S G E Howard, J Simon R Gibbs, Stuart A Cook, Martin R Wilkins, Declan P O'Regan
Purpose To measure right ventricular (RV) trabecular complexity by its fractal dimension (FD) in healthy subjects and patients with pulmonary hypertension (PH) and to assess its relationship with hemodynamic and functional parameters and future cardiovascular events. Materials and Methods This retrospective study used data acquired from May 2004 to October 2013 in 256 patients with newly diagnosed PH who underwent cardiac MRI, right-sided heart catheterization, and 6-minute walk distance testing, with median follow-up of 4...
June 5, 2018: Radiology
https://www.readbyqxmd.com/read/29867721/n-terminal-pro-brain-natriuretic-peptide-and-associations-with-brain-magnetic-resonance-imaging-mri-features-in-middle-age-the-cardia-brain-mri-study
#10
Ian T Ferguson, Martine Elbejjani, Behnam Sabayan, David R Jacobs, Osorio Meirelles, Otto A Sanchez, Russell Tracy, Nick Bryan, Lenore J Launer
Objective: As part of research on the heart-brain axis, we investigated the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with brain structure and function in a community-based cohort of middle-aged adults from the Brain Magnetic Resonance Imaging sub-study of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Approach and results: In a cohort of 634 community-dwelling adults with a mean (range) age of 50.4 (46-52) years, we examined the cross-sectional association of NT-proBNP to total, gray (GM) and white matter (WM) volumes, abnormal WM load and WM integrity, and to cognitive function tests [the Digit Symbol Substitution Test (DSST), the Stroop test, and the Rey Auditory-Verbal Learning Test]...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29861497/ischemic-stroke-caused-by-secondary-polycythemia-and-incidentally-found-renal-cell-carcinoma-a-case-report
#11
Andrew K Corse, Heather Kurtis
BACKGROUND Secondary polycythemia is a potential complication of an erythropoietin-secreting renal cell carcinoma. Increased red blood cell mass can elevate blood viscosity, which can impair blood flow, making individuals susceptible to vaso-occlusive events. One of the serious potential complications of a hyper-viscous state is ischemic stroke. CASE REPORT We present the case of a patient who was brought to the Emergency Department with right-sided extremity weakness and slurred speech consistent with acute ischemic stroke...
June 4, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29850410/kounis-syndrome-induced-by-amoxicillin-following-vasospastic-coronary-event-in-a-22-year-old-patient-a-case-report
#12
Snehasis Pradhan, Martin Christ, Hans-Joachim Trappe
This article reports the case of a 22-year-old male patient presented with electrocardiographic ST elevation and elevated cardiac biomarkers. The clinical cascade set into events within an hour of administration of a single-dose of amoxicillin on being diagnosed with acute tonsillitis. The case was preliminarily diagnosed and treated according to the acute coronary syndrome protocol, but on performing coronary angiography no abnormalities in the coronary artery were found. Acute myocarditis was excluded in cardiac MRI...
April 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29802538/effects-of-the-sglt-2-inhibitor-empagliflozin-on-renal-tissue-oxygenation-in-non-diabetic-subjects-a-randomized-double-blind-placebo-controlled-study-protocol
#13
Marie-Eve Muller, Menno Pruijm, Olivier Bonny, Michel Burnier, Anne Zanchi
INTRODUCTION: Empagliflozin is an SGLT-2 inhibitor (SGLT-2i) which belongs to a new class of hypoglycemic drugs with the unique property of decreasing blood glucose independently from insulin, through an increase in glycosuria. In addition to decreasing cardiovascular morbidity and mortality, empagliflozin has nephroprotective properties in high cardiovascular risk patients with type 2 diabetes. Decreased hyperfiltration and shifting towards more favorable renal fuel energetics with improved renal oxygenation may explain some of these properties...
May 25, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29797529/physical-deconditioning-is-the-common-denominator-in-both-obese-and-overweight-subjects-with-nonalcoholic-steatohepatitis
#14
C K Argo, J G Stine, Z H Henry, C Lackner, J T Patrie, A L Weltman, S H Caldwell
BACKGROUND: Obesity and decreased physical activity mirror increasing prevalence of nonalcoholic fatty liver disease (NAFLD). AIM: We aimed to investigate associations between aerobic fitness, anthropometrics and disease parameters in patients with nonalcoholic steatohepatitis (NASH). We hypothesised that NASH subjects have lower aerobic power and capacity than untrained, sedentary, normal subjects. METHODS: Forty subjects (60% obese, 40% overweight) with biopsy-confirmed NASH and NAFLD activity score (NAS) ≥4 were enrolled in a clinical trial where anthropometrics, laboratories, liver fat content by MRI, activity, and aerobic fitness by cycle ergometry data were obtained...
May 24, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29795012/magnetic-nanoparticles-conjugated-with-peptides-derived-from-monocyte-chemoattractant-protein-1-as-a-tool-for-targeting-atherosclerosis
#15
Chung-Wei Kao, Po-Ting Wu, Mei-Yi Liao, I-Ju Chung, Kai-Chien Yang, Wen-Yih Isaac Tseng, Jiashing Yu
Atherosclerosis is a multifactorial inflammatory disease that may progress silently for long period, and it is also widely accepted as the main cause of cardiovascular diseases. To prevent atherosclerotic plaques from generating, imaging early molecular markers and quantifying the extent of disease progression are desired. During inflammation, circulating monocytes leave the bloodstream and migrate into incipient lipid accumulation in the artery wall, following conditioning by local growth factors and proinflammatory cytokines; therefore, monocyte accumulation in the arterial wall can be observed in fatty streaks, rupture-prone plaques, and experimental atherosclerosis...
May 24, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29792210/quantitative-cardiovascular-magnetic-resonance-extracellular-volume-native-t1-and-18f-fdg-pet-cmr-imaging-in-patients-after-revascularized-myocardial-infarction-and-association-with-markers-of-myocardial-damage-and-systemic-inflammation
#16
Karl P Kunze, Ralf J Dirschinger, Hans Kossmann, Franziska Hanus, Tareq Ibrahim, Karl-Ludwig Laugwitz, Markus Schwaiger, Christoph Rischpler, Stephan G Nekolla
BACKGROUND: Characterization of tissue integrity and inflammatory processes after acute myocardial infarction (AMI) using non-invasive imaging is predictive of patient outcome. Quantitative cardiovascular magnetic resonance (CMR) techniques such as native T1 and extracellular volume (ECV) mapping as well as 18 F-FDG positron emission tomography (PET) imaging targeting inflammatory cell populations are gaining acceptance, but are often applied without assessing their quantitative potential...
May 24, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29790225/can-cardiovascular-mri-be-used-to-more-definitively-characterize-cardiac-masses-initially-identified-using-echocardiography
#17
Vikas K Rathi, Anna T Czajka, Diane V Thompson, Mark Doyle, Tarun Tewatia, June Yamrozik, Ronald B Williams, Robert W W Biederman
In diagnosing cardiac and paracardiac masses, cardiac MRI (CMR) has gained acceptance as the gold standard. CMR has been observed to be superior to echocardiography in characterizing soft-tissue structures and, specifically, in classifying cardiac masses. The aim of our study was to evaluate the association between mortality and cardiac or paracardiac masses initially identified by echocardiography (ECHO) and confirmed by CMR. Between January 2002 and August 2007, a total of 158 patients underwent both ECHO and CMR for the evaluation of cardiac masses that were equivocal or undefined by ECHO...
May 2018: Echocardiography
https://www.readbyqxmd.com/read/29788059/impact-of-right-ventricular-volume-and-function-evaluated-using-cardiovascular-magnetic-resonance-imaging-on-outcomes-after-surgical-ventricular-reconstruction
#18
Sachiko Yamazaki, Satoshi Numata, Tomoya Inoue, Keiichi Itatani, Kazuki Morimoto, Suguru Ohira, Kaichiro Manabe, Isao Yokota, Hitoshi Yaku
OBJECTIVES: This study aimed to evaluate whether cardiac magnetic resonance imaging (MRI)-derived right ventricular (RV) assessment can facilitate risk stratification among patients with ischaemic cardiomyopathy who underwent surgical ventricular reconstruction (SVR). METHODS: We retrospectively analysed 53 patients who underwent SVR. The patients were preoperatively evaluated using cardiac MRI. Cine-MRI was acquired for left ventricular (LV) and RV volume. Gadolinium-enhanced MRI was performed to evaluate LV scarring...
May 17, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29787864/the-neonatal-brain-in-critical-congenital-heart-disease-insights-and-future-directions
#19
REVIEW
Shabnam Peyvandi, Beatrice Latal, Steven P Miller, Patrick S McQuillen
Neurodevelopmental outcomes are impaired in survivors of critical congenital heart disease (CHD) in several developmental domains including motor, cognitive and sensory outcomes. These deficits can extend into the adolescent and early adulthood years. The cause of these neurodevelopmental impairments is multi-factorial and includes patient specific risk factors, cardiac anatomy and physiology as well as brain changes seen on MRI. Advances in imaging techniques have identified delayed brain development in the neonate with critical CHD as well as acquired brain injury...
May 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29784492/electrocardiogram-and-imaging-an-integrated-approach-to-arrhythmogenic-cardiomyopathies
#20
REVIEW
Ketty Savino, Giuseppe Bagliani, Federico Crusco, Margherita Padeletti, Massimo Lombardi
Cardiovascular imaging has radically changed the management of patients with arrhythmogenic cardiomyopathies. This article focuses on the role of echocardiography and MRI in the diagnosis of these structural diseases. Cardiomyopathies with hypertrophic pattern (hypertrophic cardiomyopathy, restrictive cardiomyopathies, amyloidosis, Anderson-Fabry disease, and sarcoidosis), cardiomyopathies with dilated pattern, inflammatory cardiac diseases, and right ventricular arrhythmogenic cardiomyopathy are analyzed. Finally, anatomic predictors of arrhythmias and sudden cardiac death are discussed...
June 2018: Cardiac Electrophysiology Clinics
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