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Cardiovascular MRI

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https://www.readbyqxmd.com/read/29682783/optimized-respiratory-resolved-motion-compensated-3d-cartesian-coronary-mr-angiography
#1
Teresa Correia, Giulia Ginami, Gastão Cruz, Radhouene Neji, Imran Rashid, René M Botnar, Claudia Prieto
PURPOSE: To develop a robust and efficient reconstruction framework that provides high-quality motion-compensated respiratory-resolved images from free-breathing 3D whole-heart Cartesian coronary magnetic resonance angiography (CMRA) acquisitions. METHODS: Recently, XD-GRASP (eXtra-Dimensional Golden-angle RAdial Sparse Parallel MRI) was proposed to achieve 100% scan efficiency and provide respiratory-resolved 3D radial CMRA images by exploiting sparsity in the respiratory dimension...
April 22, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29674325/adenylate-cyclase-type-9-adcy9-inactivation-protects-from-atherosclerosis-only-in-the-absence-of-cholesteryl-ester-transfer-protein-cetp
#2
Yohann Rautureau, Vanessa Deschambault, Marie-Ève Higgins, Daniel Rivas, Mélanie Mecteau, Pascale Geoffroy, Géraldine Miquel, Kurunradeth Uy, Rocio Sanchez, Véronique Lavoie, Geneviève Brand, Audrey Nault, Pierre-Marc Williams, Maria Laura Suarez, Nolwenn Merlet, Line Lapointe, Natacha Duquette, Marc-Antoine Gillis, Samaneh Samami, Gaétan Mayer, Philippe Pouliot, Adeline Raignault, Foued Maafi, Mathieu R Brodeur, Sylvie Levesque, Marie-Claude Guertin, Marie-Pierre Dubé, Éric Thorin, David Rhainds, Éric Rhéaume, Jean-Claude Tardif
Background -Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the cholesteryl ester transfer protein (CETP) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging. The underlying mechanisms responsible for the interactions between ADCY9 and CETP activity have not yet been determined. Methods - Adcy9 -inactivated ( Adcy9 Gt/Gt ) and wild-type (WT) mice, that were or not transgenic for the CETP gene (CETPtg Adcy9 Gt/Gt and CETPtg Adcy9 WT ), were submitted to an atherogenic protocol (injection of an AAV8 expressing a PCSK9 gain-of-function variant and 0...
April 19, 2018: Circulation
https://www.readbyqxmd.com/read/29672672/mri-and-neuropsychological-correlates-in-african-americans-with-hypertension-and-left-ventricular-hypertrophy
#3
B Waldron-Perrine, J E Kisser, A Brody, E M Haacke, R Dawood, S Millis, P Levy
Background: African Americans (AA) are at high risk for hypertension (HTN) and poor blood pressure (BP) control. Persistently elevated BP contributes to cardiovascular morbidity. White matter hyperintensities (WMH) are a definable magnetic resonance imaging (MRI) marker of cerebrovascular injury linked to impairments in higher level thinking (i.e., executive functions), memory formation and speed of perceptual-motor processing. Methods: This sub-investigation evaluated neuropsychological functioning in association with WMH on brain MRIs in 23 otherwise healthy hypertensive AAs participating in an NIH-funded study of the effects of Vitamin D on BP and cardiac remodeling in AA patients 30-74 years of age with HTN and left ventricular hypertrophy...
April 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29663313/microbleeds-in-ischemic-vs-hemorrhagic-strokes-on-novel-oral-anticoagulants
#4
J C Purrucker, M Wolf, K Haas, T Siedler, T Rizos, S Khan, P U Heuschmann, R Veltkamp
OBJECTIVES: To identify differences in clinical characteristics and severity of cerebral small vessel disease (CSVD) including cerebral microbleeds (CMBs), between patients suffering ischemic stroke (IS) or intracerebral hemorrhage (ICH) while taking novel (non-vitamin K antagonists) oral anticoagulants (NOACs). METHODS: Multicenter, prospective, observational cohort study performed at 38 centers between 2012 and 2015. We compared demographics, comorbidity, and functional status (before and after stroke) between NOAC-IS and NOAC-ICH patients...
April 16, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29663188/magnetic-resonance-imaging-during-management-of-patients-with-transfusion-dependent-thalassemia-a-single-center-experience
#5
Zeynep Karakas, Yasin Yilmaz, Zuhal Bayramoglu, Serap Karaman, Selime Aydogdu, Ayse Ozkan Karagenc, Deniz Tugcu, Memduh Dursun
BACKGROUND: Cardiac and hepatic magnetic resonance imaging evaluation during treatment can tailor physicians' chelation therapy titrations. AIM: The aim of the study was to assess the relationship of cardiac and hepatic T2* values with chelation therapy in patients with transfusion-dependent thalassemia (TDT). METHODS: A total of 106 patients with TDT who were followed up in Istanbul Medical Faculty Thalassemia Center were evaluated for the study...
April 16, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29660944/cardiovascular-response-to-mental-stress-in-mild-cognitive-impairment-and-its-association-with-cerebral-perfusion
#6
Brandon C Henley, Mahsa Shokouhi, Anushree Y Mahajan, Omer T Inan, Ihab Hajjar
Mental stress has been linked to various chronic diseases including Alzheimer's disease, but the mechanisms underlying cognitive decline with mental stress are unknown. Reduced cardiovascular response to stress is associated with cardiovascular disease, and the latter is associated with cognitive impairment. We measured electrodermal activity, blood pressure, and cardiac hemodynamics in cognitively normal and mild cognitive impairment (MCI) adults (n = 76, mean age = 58 years, 46% MCI) during rest, a math test, and face-name recall tasks to derive the following cardiovascular indicators: mean arterial pressure, heart rate, stroke volume and cardiac output...
April 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29660591/inverse-relationship-between-the-evans-index-and-cognitive-performance-in-non-disabled-stroke-free-community-dwelling-older-adults-a-population-based-study
#7
Oscar H Del Brutto, Robertino M Mera, Danielle Gladstone, María Sarmiento-Bobadilla, Kristen Cagino, Mauricio Zambrano, Aldo F Costa, Mark J Sedler
OBJECTIVE: The Evans Index (EI) is used for recognition of individuals with normal pressure hydrocephalus. However, recent studies suggest that the EI is not a reliable marker of this condition. Rather, the EI may be inversely correlated with cognitive performance, but information on this correlation is lacking. We aimed to assess the relationship between the EI and cognitive performance in community-dwelling older adults. PATIENTS AND METHODS: The study included 314 non-disabled, stroke-free, individuals aged ≥60 years enrolled in the Atahualpa Project undergoing brain MRI and MoCA testing...
March 30, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29652661/combined-brain-and-heart-magnetic-resonance-imaging-in-systemic-vasculitides-fiction-or-real-need
#8
REVIEW
Sophie I Mavrogeni, George Kitas, Hildo J Lamb, Klearchos Psychoyios, Theodoros Dimitroulas, Loukia Koutsogeorgopoulou, Kyriaki Boki, Vasiliki Vartela, Genovefa Kolovou, George Markousis-Mavrogenis, Cees G Kallenberg, Loic Guillevin, Dimitrios Vassilopoulos
Systemic vasculitides (SVs) is a group of diseases characterised by inflammation/necrosis of the blood vessel wall in various organs. Simultaneous brain and heart involvement is a cause of increased morbidity/mortality in SV. We aimed to present evidence of concurrent brain/heart involvement in SV and the role of a combined brain/heart magnetic resonance imaging (MRI) in their risk stratification. Cerebral vasculitis (CV) can be presented as focal deficits, seizures, headache, neuropsychiatric manifestations or cognitive dysfunction and cardiovascular disease (CVD) as myocardial/vascular inflammation, perfusion/function defects and fibrosis...
April 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29643278/absolute-myocardial-blood-flow-after-elective-percutaneous-coronary-intervention-evaluated-on-phase-contrast-cine-cardiovascular-magnetic-resonance-imaging
#9
Rikuta Hamaya, Akinori Sugano, Yoshihisa Kanaji, Tadashi Fukuda, Yoshinori Kanno, Taishi Yonetsu, Eisuke Usui, Masahiro Hoshino, Masahiro Hada, Hiroaki Ohya, Yohei Sumino, Haruhito Yuki, Tadashi Murai, Tetsumin Lee, Tsunekazu Kakuta
BACKGROUND: Few studies have documented changes in myocardial blood flow (MBF) after percutaneous coronary intervention (PCI). Phase-contrast cine cardiovascular MRI (PC-CCMR) of the coronary sinus (CS) is a promising approach to quantify MBF. The aim of this study was to quantify CS flow (CSF) on PC-CCMR as a measure of volumetric MBF before and after elective PCI.Methods and Results:We prospectively studied 34 patients with stable angina undergoing elective PCI for a single de novo lesion...
April 12, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29643080/periodic-limb-movements-during-sleep-in-stroke-tia-prevalence-course-and-cardiovascular-burden
#10
Mauro Manconi, Francesco Fanfulla, Raffaele Ferri, Silvia Miano, Josè Haba-Rubio, Raphael Heinzer, Thomas Horvath, Paola Proserpio, Peter Young, Giorgio Moschovitis, Andrea Seiler, Carlo Cereda, Lino Nobili, Roland Wiest, Sebastian R Ott, Claudio L Bassetti
OBJECTIVE: To define the prevalence, time course, and associated factors of periodic limb movements during sleep (PLMS) in patients with ischemic stroke or TIA. METHODS: Patients enrolled in the prospective Sleep-Disordered Breathing in Transient Ischemia Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy (SAS-CARE) study underwent a double polysomnographic investigation in the acute and chronic phases after stroke/TIA, together with a MRI brain scan and a 24-hour blood pressure evaluation...
April 11, 2018: Neurology
https://www.readbyqxmd.com/read/29627018/bilateral-wallerian-degeneration-of-the-middle-cerebellar-peduncles-secondary-to-pontine-infarction-a-case-series
#11
Yaoyao Shen, Wen Jian, Juan Li, Tingmin Dai, Bing Bao, Hongbing Nie
OBJECTIVE: Wallerian degeneration (WD) of middle cerebellar peduncles (MCPs) secondary to pontine infarction is rarely reported in the literature. Our aim in this study is to characterize its clinical and neuroradiological features. METHODS: A retrospective review of 7 patients from a single institution was conducted. Only patients with pontine infarction and subsequent degeneration of the MCPs were included in the analysis. The features of clinical presentation and neuroimaging finding were summarized by our experienced neurologists...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29626940/pet-mri-in-infection-and-inflammation
#12
REVIEW
Martina Sollini, Raffaella Berchiolli, Margarita Kirienko, Alexia Rossi, A W J M Glaudemans, Riemer Slart, Paola Anna Erba
Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most of the evidence of the potential clinical utility of PET/MRI is available for neuroimaging. Other areas, where PET/MR can play a larger role include head and neck, upper abdominal, and pelvic tumours...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29618740/traumatic-brain-injury-leads-to-accelerated-atherosclerosis-in-apolipoprotein-e-deficient-mice
#13
Jintao Wang, Enming Su, Hui Wang, Chiao Guo, Daniel A Lawrence, Daniel T Eitzman
Traumatic brain injury (TBI) has been associated with atherosclerosis and cardiovascular mortality in humans. However the causal relationship between TBI and vascular disease is unclear. This study investigated the direct role of TBI on vascular disease using a murine model of atherosclerosis. Apolipoprotein E deficient mice were placed on a western diet beginning at 10 weeks of age. Induction of TBI or a sham operation was performed at 14 weeks of age and mice were sacrificed 6 weeks later at 20 weeks of age...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29611625/echocardiography-and-cardiovascular-mri-entwined-within-the-imaging-domain-uniting-the-two-a-compendium-for-the-echocardiographer
#14
Moneal B Shah, Mark Doyle, Victor Farah, Robert W W Biederman
A review of the unique and complementary roles echocardiography and cardiovascular MRI provide to the clinician. A focus on the physics of each modality as well as imaging of the left ventricle.
April 3, 2018: Echocardiography
https://www.readbyqxmd.com/read/29611320/high-fibroblast-growth-factor-23-concentrations-in-experimental-renal-failure-impair-calcium-handling-in-cardiomyocytes
#15
Melissa Verkaik, Maarten Oranje, Desiree Abdurrachim, Max Goebel, Zeineb Gam, Jeanine J Prompers, Michiel Helmes, Pieter M Ter Wee, Jolanda van der Velden, Diederik W Kuster, Marc G Vervloet, Etto C Eringa
The overwhelming majority of patients with chronic kidney disease (CKD) die prematurely before reaching end-stage renal disease, mainly due to cardiovascular causes, of which heart failure is the predominant clinical presentation. We hypothesized that CKD-induced increases of plasma FGF23 impair cardiac diastolic and systolic function. To test this, mice were subjected to 5/6 nephrectomy (5/6Nx) or were injected with FGF23 for seven consecutive days. Six weeks after surgery, plasma FGF23 was higher in 5/6Nx mice compared to sham mice (720 ± 31 vs...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29606693/canadian-alliance-for-healthy-hearts-and-minds-first-nations-cohort-study-rationale-and-design
#16
Sonia S Anand, Sylvia Abonyi, Laura Arbour, Jeff Brook, Sharon Bruce, Heather Castleden, Dipika Desai, Russell J de Souza, Stewart Harris, James Irvine, Christopher Lai, Diana Lewis, Richard T Oster, Paul Poirier, Ellen L Toth, Karen Bannon, Vicky Chrisjohn, Albertha D Davis, Jean L'Hommecourt, Randy Littlechild, Kathleen McMullin, Sarah McIntosh, Julie Morrison, Manon Picard, Pictou Landing First Nation, Melissa M Thomas, Natasa Tusevljak, Matthias G Friedrich, Jack V Tu
BACKGROUND: This is the first national indigenous cohort study in which a common, in-depth protocol with a common set of objectives has been adopted by several indigenous communities across Canada. OBJECTIVES: The overarching objective of the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort is to investigate how the community-level environment is associated with individual health behaviors and the presence and progression of chronic disease risk factors and chronic diseases such as cardiovascular disease (CVD) and cancer...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29601409/correlation-of-mri-derived-adipose-tissue-measurements-and-anthropometric-markers-with-prevalent-hypertension-in-the-community
#17
Roberto Lorbeer, Susanne Rospleszcz, Christopher L Schlett, Sophia D Heber, Jürgen Machann, Barbara Thorand, Christa Meisinger, Margit Heier, Annette Peters, Fabian Bamberg, Wolfgang Lieb
OBJECTIVES: To compare the correlations of MRI-derived adipose tissue measurements and anthropometric markers, respectively, with prevalent hypertension in a community-based sample, free of clinical cardiovascular disease. METHODS: MRI-derived adipose tissue measurements were obtained in 345 participants (143 women; age 39-73 years) of the KORA FF4 survey from Southern Germany using a 3-Tesla machine and included total adipose tissue (TAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SCAT), hepatic fat fraction (HFF), pancreatic fat fraction (PFF) as well as pericardial adipose tissue (PAT)...
March 29, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29590330/arterial-stiffening-is-a-heritable-trait-associated-with-arterial-dilation-but-not-wall-thickening-a-longitudinal-study-in-the-twins-uk-cohort
#18
Marina Cecelja, Benyu Jiang, Louise Keehn, Tarique Hussain, Miguel Silva Vieira, Alkystis Phinikaridou, Gerald Greil, Tim D Spector, Phil Chowienczyk
Aims: Vascular ageing is characterized by arterial stiffening, dilation, and arterial wall thickening. We investigated the extent to which these changes are related and their heritability during 5 year follow-up in the Twins UK cohort. Methods and results: Carotid-femoral pulse wave velocity (PWVcf), carotid diameter, carotid distensibility, and carotid intima-media thickness (IMT) were measured in 762 female twins (mean age 57.9 ± 8.6 years) at two time-points over an average follow-up of 4...
March 26, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29579673/associations-between-normal-range-albuminuria-renal-function-and-cardiovascular-function-in-a-population-based-imaging-study
#19
Ilona A Dekkers, Renée de Mutsert, Ton J Rabelink, Johan W Jukema, Albert de Roos, Frits R Rosendaal, Hildo J Lamb, Aiko P J de Vries
BACKGROUND AND AIMS: In patients with impaired renal function and macroalbuminuria, cardiovascular risk factors are highly prevalent, however, whether this is also present in the general population is unclear. We investigated whether normal-range albuminuria and renal function are associated with cardiovascular function in the general population. METHODS: In this cross-sectional analysis of the NEO study, urinary albumin-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and intima-media thickness were assessed in all participants (n = 6503), and a random subset underwent MRI for pulse wave velocity (n = 2451) and/or cardiac imaging (n = 1138)...
March 16, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29573034/appropriate-utilization-of-cardiac-magnetic-resonance-for-the-assessment-of-heart-failure-and-potential-associated-cost-savings
#20
Nishchay Kaushal, Harindra C Wijeysundera, Kim A Connelly, Idan Roifman
BACKGROUND: The rapid growth in cardiac imaging utilization has led to the development of appropriate use criteria (AUC) in an effort to control costs. Recently, cardiac MRI has developed into a valuable modality in the evaluation of cardiac disease. However, there are no studies examining the appropriate use of cardiac MRI in clinical practice. PURPOSE: To determine the appropriate utilization of cardiac MRI in a large quaternary care institution and to compare percentages of appropriate utilization pre- and postpublication of the AUC document...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
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