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Cardiovascular MRI

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https://www.readbyqxmd.com/read/28209728/evaluation-of-cell-therapy-on-exercise-performance-and-limb-perfusion-in-peripheral-artery-disease-the-cctrn-patients-with-intermittent-claudication-injected-with-aldh-bright-cells-pace-trial
#1
Emerson C Perin, Michael P Murphy, Keith L March, Roberto Bolli, John Loughran, Phillip C Yang, Nicholas J Leeper, Ronald L Dalman, Jason Q Alexander, Timothy D Henry, Jay H Traverse, Carl J Pepine, R David Anderson, Scott Berceli, James T Willerson, Raja Muthupillai, Amir A Gahremanpour, Ganesh Raveendran, Omaida C Velazquez, Joshua M Hare, Ivonne H Schulman, Vijaykumar S Kasi, William R Hiatt, Bharath Ambale-Venkatesh, João A Lima, Doris A Taylor, Micheline M Resende, Adrian P Gee, April G Durett, Jeannette Bloom, Sara Richman, Patricia G'Sell, Shari Williams, Fouzia Khan, Elsie G Ross, Michelle R Santoso, JoAnne Goldman, Dana Leach, Eileen Handberg, Benjamin Y C Cheong, Nichole A Piece, Darcy DiFede, Barb Bruhn-Ding, Emily Caldwell, Judy Bettencourt, Dejian Lai, Linda B Piller, Lara M Simpson, Michelle Cohen, Shelly L Sayre, Rachel W Vojvodic, Lem Moyé, Ray F Ebert, Robert D Simari, Alan T Hirsch
Background -Atherosclerotic peripheral artery disease (PAD) affects 8-12% of Americans over 65 and is associated with a major decline in functional status, increased myocardial infarction and stroke rates, and increased risk of ischemic amputation. Current treatment strategies for claudication have limitations. PACE is an NHLBI-sponsored, randomized, double-blind, placebo-controlled phase 2, exploratory clinical trial designed to assess safety and efficacy of autologous bone marrow-derived aldehyde dehydrogenase bright (ALDHbr) cells in PAD patients and to explore associated claudication physiologic mechanisms...
February 16, 2017: Circulation
https://www.readbyqxmd.com/read/28207773/local-versus-global-aortic-pulse-wave-velocity-in-early-atherosclerosis-an-animal-study-in-apoe-mice-using-ultrahigh-field-mri
#2
Alexander Gotschy, Wolfgang R Bauer, Patrick Winter, Peter Nordbeck, Eberhard Rommel, Peter M Jakob, Volker Herold
Increased aortic stiffness is known to be associated with atherosclerosis and has a predictive value for cardiovascular events. This study aims to investigate the local distribution of early arterial stiffening due to initial atherosclerotic lesions. Therefore, global and local pulse wave velocity (PWV) were measured in ApoE-/- and wild type (WT) mice using ultrahigh field MRI. For quantification of global aortic stiffness, a new multi-point transit-time (TT) method was implemented and validated to determine the global PWV in the murine aorta...
2017: PloS One
https://www.readbyqxmd.com/read/28188213/non-invasive-stratification-of-postinfarction-rats-based-on-degree-of-cardiac-dysfunction-using-magnetic-resonance-imaging-and-echocardiography
#3
Jan Magnus Aronsen, Emil Knut Stenersen Espe, Kristine Skårdal, Almira Hasic, Lili Zhang, Ivar Sjaastad
The myocardial infarction (MI) rat model plays a crucial role in modern cardiovascular research, but the inherent heterogeneity of this model represents a challenge. We sought to identify subgroups among the post-MI rats, and establish simple non-invasive stratification protocols for such subgroups. Six weeks after induction of MI, 49 rats underwent non-invasive examinations using magnetic resonance imaging (MRI) and echocardiography. 12 sham-operated rats served as controls. Increased end-diastolic left ventricular (LV) pressure and lung weight served as indicators for congestive heart failure (CHF)...
February 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28184976/decreased-diastolic-ventricular-kinetic-energy-in-young-patients-with-fontan-circulation-demonstrated-by-four-dimensional-cardiac-magnetic-resonance-imaging
#4
Pia Sjöberg, Einar Heiberg, Pär Wingren, Jens Ramgren Johansson, Torsten Malm, Håkan Arheden, Petru Liuba, Marcus Carlsson
Four-dimensional (4D) flow magnetic resonance imaging (MRI) enables quantification of kinetic energy (KE) in intraventricular blood flow. This provides a novel way to understand the cardiovascular physiology of the Fontan circulation. In this study, we aimed to quantify the KE in functional single ventricles. 4D flow MRI was acquired in eleven patients with Fontan circulation (median age 12 years, range 3-29) and eight healthy volunteers (median age 26 years, range 23-36). Follow-up MRI after surgical or percutaneous intervention was performed in 3 patients...
February 10, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28184962/magnetic-resonance-imaging-4-d-flow-based-analysis-of-aortic-hemodynamics-in-turner-syndrome
#5
Raoul Arnold, Marie Neu, Daniel Hirtler, Charlotte Gimpel, Michael Markl, Julia Geiger
BACKGROUND: Cardiovascular surveillance is important in Turner syndrome because of the increased risk of aortic dilation and dissection with consecutively increased mortality. OBJECTIVE: To compare 4-D flow MRI for the characterization of aortic 3-D flow patterns, dimensions and vessel wall parameters in pediatric patients with Turner syndrome and age-matched controls. MATERIALS AND METHODS: We performed 4-D flow MRI measuring in vivo 3-D blood flow with coverage of the thoracic aorta in 25 patients with Turner syndrome and in 16 female healthy controls (age mean ± standard deviation were 16 ± 5 years and 17 ± 4 years, respectively)...
February 9, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28184203/prefrontal-parietal-white-matter-volumes-in-healthy-elderlies-are-decreased-in-proportion-to-the-degree-of-cardiovascular-risk-and-related-to-inhibitory-control-deficits
#6
Pedro P Santos, Paula S Da Silveira, Fabio L Souza-Duran, Jaqueline H Tamashiro-Duran, Márcia Scazufca, Paulo R Menezes, Claudia Da Costa Leite, Paulo A Lotufo, Homero Vallada, Maurício Wajngarten, Tânia C De Toledo Ferraz Alves, Patricia Rzezak, Geraldo F Busatto
Cardiovascular risk (CVR) factors may be associated with poor cognitive functioning in elderlies and impairments in brain structure. Using MRI and voxel-based morphometry (VBM), we assessed regional white matter (WM) volumes in a population-based sample of individuals aged 65-75 years (n = 156), subdivided in three CVR subgroups using the Framingham Risk Score. Cognition was assessed using the Short Cognitive Performance Test. In high-risk subjects, we detected significantly reduced WM volume in the right juxtacortical dorsolateral prefrontal region compared to both low and intermediate CVR subgroups...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28180080/simultaneous-investigation-of-microvasculature-and-parenchyma-in-cerebral-small-vessel-disease-using-intravoxel-incoherent-motion-imaging
#7
Sau May Wong, C Eleana Zhang, Frank C G van Bussel, Julie Staals, Cécile R L P N Jeukens, Paul A M Hofman, Robert J van Oostenbrugge, Walter H Backes, Jacobus F A Jansen
INTRODUCTION: Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD to assess the microvasculature and parenchymal microstructure. METHODS: Seventy-three patients with cSVD (age 70 ± 11 y) and thirty-nine controls (age 69 ± 12 y) underwent IVIM imaging (3T)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28179448/the-igf-system-in-patients-with-type-2-diabetes-associations-with-markers-of-cardiovascular-target-organ-damage
#8
Rikke Hjortebjerg, Esben Laugesen, Pernille Høyem, Claus Oxvig, Brian Stausbøl-Grøn, Søren Tang Knudsen, Won Y Kim, Per Løgstrup Poulsen, Tk K Hansen, Mette Bjerre, Jan Frystyk
OBJECTIVE: Perturbations in the insulin-like growth factor (IGF) system may contribute to the accelerated cardiovascular disease (CVD) that occurs in patients with type 2 diabetes (T2D). However, it remains unknown whether the IGF system is also involved in the development of early, subclinical CVD. We characterised the IGF system in T2D patients and matched controls and examined associations with markers of subclinical target organ damage. METHODS: The study included 99 patients with recently diagnosed T2D and 99 age- and sex-matched controls...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28153991/sex-based-differences-in-cardiometabolic-biomarkers
#9
Jeanney Lew, Monika Sanghavi, Colby R Ayers, Darren K McGuire, Torbjørn Omland, Dorothee Atzler, Maria O Gore, Ian Neeland, Jarett D Berry, Amit Khera, Anand Rohatgi, James A de Lemos
BACKGROUND: Few data are available comparing cardiovascular disease (CVD) biomarker profiles between women and men in the general population. We analyzed sex-based differences in multiple biomarkers reflecting distinct pathophysiological pathways, accounting for differences between women and men in CVD risk factors, body composition, and cardiac morphology. METHODS: A cross-sectional analysis was performed using data from the Dallas Heart Study, a multiethnic population-based study...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28152235/community-delivery-of-semiautomated-fractal-analysis-tool-in-cardiac-mr-for-trabecular-phenotyping
#10
Gabriella Captur, Dina Radenkovic, Chunming Li, Yu Liu, Nay Aung, Filip Zemrak, Catalina Tobon-Gomez, Xuexin Gao, Perry M Elliott, Steffen E Petersen, David A Bluemke, Matthias G Friedrich, James C Moon
PURPOSE: To report the development of easy-to-use magnetic resonance imaging (MRI) fractal tools deployed on platforms accessible to all. The trabeculae of the left ventricle vary in health and disease but their measurement is difficult. Fractal analysis of cardiac MR images can measure trabecular complexity as a fractal dimension (FD). MATERIALS AND METHODS: This Health Insurance Portability and Accountability Act (HIPAA)-compliant study was approved by the local Institutional Review Board...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28131907/3d-late-gadolinium-enhanced-cardiovascular-mr-with-centra-plus-profile-view-ordering-feasibility-of-right-ventricular-myocardial-damage-assessment-using-a-swine-animal-model
#11
Keigo Kawaji, Akiko Tanaka, Mita B Patel, Hui Wang, Francesco Maffessanti, Takeyoshi Ota, Amit R Patel
AIMS: To develop a high-resolution, 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (MRI) technique for improved assessment of myocardial scars, and evaluate its performance against 2D breath-held (BH) LGE MRI using a surgically implanted animal scar model in the right ventricle (RV). METHODS AND RESULTS: A k-space segmented 3D LGE acquisition using CENTRA-PLUS (Contrast ENhanced Timing Robust Acquisition with Preparation of LongitUdinal Signal; or CP) ordering is proposed...
January 25, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28131593/pet-mri-in-children
#12
Sergios Gatidis, Benjamin Bender, Matthias Reimold, Jürgen F Schäfer
During the past decade, combined PET/MRI has been translated from a basic technical concept to a clinical research tool and a clinically applied hybrid imaging modality. Numerous clinical and scientific applications have been proposed for this novel hybrid modality including oncologic, neurologic and cardiovascular imaging. Among these, PET/MRI in children has emerged as a key application, not only due to possible diagnostic advantages but also because of reduced radiation exposure compared to alternative techniques...
January 21, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28130811/relation-between-brown-adipose-tissue-and-measures-of-obesity-and-metabolic-dysfunction-in-patients-with-cardiovascular-disease
#13
Bas T Franssens, Hans Hoogduin, Tim Leiner, Yolanda van der Graaf, Frank L J Visseren
PURPOSE: To evaluate whether brown adipose tissue (BAT) is present in middle-aged patients with cardiovascular comorbidities and to quantify how BAT presence associates with obesity and metabolic dysfunction. MATERIALS AND METHODS: Supraclavicular and subcutaneous adipose tissue fat-signal-fraction (FF) was determined with 1.5T water-fat magnetic resonance imaging (MRI) in 50 patients with coronary artery disease, cerebrovascular disease, or peripheral artery disease...
January 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28123651/the-association-between-poor-sleep-quality-and-global-cortical-atrophy-is-related-to-age-results-from-the-atahualpa-project
#14
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Pablo R Castillo
Community-dwellers aged ≥60 years enrolled in the Atahualpa Project underwent brain MRI and were interviewed with the Pittsburgh Sleep Quality Index. Of 290 participants, 94 (32%) had poor sleep quality and 143 (49%) had global cortical atrophy (GCA). In a logistic regression model (adjusted for demographics, cardiovascular risk factor, severe edentulism, symptoms of depression, the MoCA score, and neuroimaging signatures of cerebrovascular damage), poor sleep quality was associated with GCA (p=0.004). A multivariate probability model showed that the probability of moderate-to-severe GCA significantly increased in individuals with poor sleep quality aged ≥67 years...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28122851/intradialytic-cardiac-magnetic-resonance-imaging-to-assess-cardiovascular-responses-in-a-short-term-trial-of-hemodiafiltration-and-hemodialysis
#15
Charlotte Buchanan, Azharuddin Mohammed, Eleanor Cox, Katrin Köhler, Bernard Canaud, Maarten W Taal, Nicholas M Selby, Susan Francis, Chris W McIntyre
Hemodynamic stress during hemodialysis (HD) results in recurrent segmental ischemic injury (myocardial stunning) that drives cumulative cardiac damage. We performed a fully comprehensive study of the cardiovascular effect of dialysis sessions using intradialytic cardiac magnetic resonance imaging (MRI) to examine the comparative acute effects of standard HD versus hemodiafiltration (HDF) in stable patients. We randomly allocated 12 patients on HD (ages 32-72 years old) to either HD or HDF. Patients were stabilized on a modality for 2 weeks before undergoing serial cardiac MRI assessment during dialysis...
November 10, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28118280/low-dose-eplerenone-decreases-left-ventricular-mass-in-treatment-resistant-hypertension
#16
Andreas Schneider, Johannes Schwab, Marina V Karg, Tatjana Kalizki, Annemarie Reinold, Ingrid Bär, Markus P Schneider, Roland E Schmieder, Bernhard M W Schmidt
BACKGROUND: Mineralocorticoid receptor antagonists are increasingly used in patients with treatment-resistant hypertension (TRH). There is experimental evidence for blood pressure (BP) independent effects of mineralocorticoid receptor blockade on cardiovascular target organ damage. We hypothesized that low-dose eplerenone (50 mg) will reduce left ventricular mass (LVM) beyond its BP-lowering effects. METHODS: We performed a randomized, double-blind, placebo-controlled, parallel group study in 51 patients with TRH...
January 23, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28116270/a-rare-case-of-multiple-rice-bodies-in-glenohumeral-joint-subscapular-recess-and-along-long-head-of-biceps
#17
Prashanth Chalasani, Satyakumar Koduru, Kavya Mikkineni
INTRODUCTION: Synovial chondromatosis is a rare, generally benign condition which affects the synovial membranes and commonly involves the large joints such as the knee, and hip. It is usually mono-articular and more common in males. Synovial chondromatosis is characterized by the presence of multiple cartilaginous nodules in the joint synovium. The definitive diagnosis is achieved after the pathological examination of the synovial tissue. It can be very destructive and can cause severe osteoarthritis, pain and malignant transformation...
July 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28113280/miniaturizing-floating-traps-to-increase-rf-safety-of-magnetic-resonance-guided-percutaneous-procedures
#18
Gregory Griffin, Kevan Anderson, Graham Wright
OBJECTIVE: MRI in the area of cardiovascular catheter-based interventional procedures is an active field. A common intervention - revascularization of chronic total occlusions, requires a conductive guidewire for revascularization. The mechanical properties of guidewires are paramount to the successful execution of such procedures. Furthermore to benefit from MRI techniques, additional conductors are required to transmit signal from the tip of a catheter. Long thin conductors in MRI systems pose a safety risk in the form of RF heating due to induced RF currents on the conductors...
April 20, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28113187/miniaturizing-floating-traps-to-increase-rf-safety-of-magnetic-resonance-guided-percutaneous-procedures
#19
Gregory H Griffin, Kevan J T Anderson, Graham A Wright
OBJECTIVE: MRI in the area of cardiovascular catheter-based interventional procedures is an active field. A common intervention-revascularization of chronic total occlusions, requires a conductive guidewire for revascularization. The mechanical properties of guidewires are paramount to the successful execution of such procedures. Furthermore to benefit from MRI techniques, additional conductors are required to transmit signal from the tip of a catheter. Long thin conductors in MRI systems pose a safety risk in the form of RF heating due to induced RF currents on the conductors...
February 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28101804/white-matter-hyperintensities-correlate-to-cognition-and-fiber-tract-integrity-in-older-adults-with-hiv
#20
Christa Watson, Edgar Busovaca, Jessica M Foley, I Elaine Allen, Christopher G Schwarz, Neda Jahanshad, Talia M Nir, Pardis Esmaeili-Firidouni, Benedetta Milanini, Howard Rosen, Owen T Carmichael, Paul M Thompson, Victor G Valcour
Our aim was to examine the clinical relevance of white matter hyperintensities (WMH) in HIV. We used an automated approach to quantify WMH volume in HIV seropositive (HIV+; n = 65) and HIV seronegative (HIV-; n = 29) adults over age 60. We compared WMH volumes between HIV+ and HIV- groups in cross-sectional and multiple time-point analyses. We also assessed correlations between WMH volumes and cardiovascular, HIV severity, cognitive scores, and diffusion tensor imaging variables. Serostatus groups did not differ in WMH volume, but HIV+ participants had less cerebral white matter (mean: 470...
January 18, 2017: Journal of Neurovirology
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