Stephanie Fuchs, Julia S Caserto, Qingsheng Liu, Kecheng Wang, Kaavian Shariati, Chase M Hartquist, Xuanhe Zhao, Minglin Ma
Automated delivery of insulin based on continuous glucose monitoring is revolutionizing the way insulin-dependent diabetes is treated. However, challenges remain for the widespread adoption of these systems, including the requirement of a separate glucose sensor, sophisticated electronics and algorithms, and the need for significant user input to operate these costly therapies. Herein, we report a user-centric glucose-responsive cannula for electronics-free insulin delivery. The cannula -made from a tough, elastomer-hydrogel hybrid membrane formed through a one-pot solvent exchange method- changes permeability to release insulin rapidly upon physiologically relevant varying glucose levels, providing simple and automated insulin delivery with no additional hardware or software...
April 19, 2024: Advanced Materials