keyword
MENU ▼
Read by QxMD icon Read
search

Brain glucose metabolism

keyword
https://www.readbyqxmd.com/read/28718701/occludin-regulates-glucose-uptake-and-atp-production-in-pericytes-by-influencing-amp-activated-protein-kinase-activity
#1
Victor Castro, Marta Skowronska, Jorge Lombardi, Jane He, Neil Seth, Martina Velichkovska, Michal Toborek
Energetic regulation at the blood-brain barrier is critical for maintaining its integrity, transport capabilities, and brain demands for glucose. However, the underlying mechanisms that regulate these processes are still poorly explored. We recently characterized the protein occludin as a NADH oxidase and demonstrated its influence on the expression and activation of the histone deacetylase SIRT-1. Because SIRT-1 works in concert with AMP-activated protein kinase (AMPK) (AMPK), we investigated the impact of occludin on this metabolic switch...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28717164/glucagon-like-peptide-1-reduces-pancreatic-%C3%AE-cell-mass-through-hypothalamic-neural-pathways-in-high-fat-diet-induced-obese-rats
#2
Hisae Ando, Koro Gotoh, Kansuke Fujiwara, Manabu Anai, Seiichi Chiba, Takayuki Masaki, Tetsuya Kakuma, Hirotaka Shibata
We examined whether glucagon-like peptide-1 (GLP-1) affects β-cell mass and proliferation through neural pathways, from hepatic afferent nerves to pancreatic efferent nerves via the central nervous system, in high-fat diet (HFD)-induced obese rats. The effects of chronic administration of GLP-1 (7-36) and liraglutide, a GLP-1 receptor agonist, on pancreatic morphological alterations, c-fos expression and brain-derived neurotrophic factor (BDNF) content in the hypothalamus, and glucose metabolism were investigated in HFD-induced obese rats that underwent hepatic afferent vagotomy (VgX) and/or pancreatic efferent sympathectomy (SpX)...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716225/regional-cerebral-glucose-metabolism-in-systemic-lupus-erythematosus-patients-with-major-depressive-disorder
#3
Tomoyuki Saito, Maasa Tamura, Yuhei Chiba, Omi Katsuse, Akira Suda, Ayuko Kamada, Takahiro Ikura, Kie Abe, Matsuyoshi Ogawa, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Atsushi Ihata, Yoshio Hirayasu
OBJECTIVES: Depression is frequently observed in patients with systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) patients often exhibit cerebral hypometabolism, but the association between cerebral metabolism and depression remains unclear. To elucidate the features of cerebral metabolism in SLE patients with depression, we performed brain 18F-fluoro-d-glucose positron emission tomography (FDG-PET) on SLE patients with and without major depressive disorder. METHODS: We performed brain FDG-PET on 20 SLE subjects (5 male, 15 female)...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28714862/a-leptin-regulated-circuit-controls-glucose-mobilization-during-noxious-stimuli
#4
Jonathan N Flak, Deanna Arble, Warren Pan, Christa Patterson, Thomas Lanigan, Paulette B Goforth, Jamie Sacksner, Maja Joosten, Donald A Morgan, Margaret B Allison, John Hayes, Eva Feldman, Randy J Seeley, David P Olson, Kamal Rahmouni, Martin G Myers
Adipocytes secrete the hormone leptin to signal the sufficiency of energy stores. Reductions in circulating leptin concentrations reflect a negative energy balance, which augments sympathetic nervous system (SNS) activation in response to metabolically demanding emergencies. This process ensures adequate glucose mobilization despite low energy stores. We report that leptin receptor-expressing neurons (LepRb neurons) in the periaqueductal gray (PAG), the largest population of LepRb neurons in the brain stem, mediate this process...
July 17, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28713979/roles-of-electro-acupuncture-in-glucose-metabolism-as-assessed-by-18f-fdg-pet-imaging-and-ampk%C3%AE-phosphorylation-in-rats-with-ischemic-stroke
#5
Jingsong Wu, Bingbing Lin, Weilin Liu, Jia Huang, Guanhao Shang, Yunjiao Lin, Lulu Wang, Lidian Chen, Jing Tao
Targeted energy metabolism balance contributes to neural survival during ischemic stroke. Herein, we tested the hypothesis that electro‑acupuncture (EA) can enhance cerebral glucose metabolism assessed by 18F‑fluorodeoxyglucose/positron emission tomography (18F‑FDG/PET) imaging to prevent propagation of tissue damage and improve neurological outcome in rats subjected to ischemia and reperfusion injury. Rats underwent middle cerebral artery occlusion (MCAO) and received EA treatment at the LI11 and ST36 acupoints or non‑acupoint treatment once a day for 7 days...
July 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28712206/spectrum-of-brain-abnormalities-detected-on-whole-body-f-18-fdg-pet-ct-scan
#6
Aamna Hassan, Yasir Majeed, Khurram Aftab
Positron emission tomography (PET) with integrated computed tomography (CT) is a unique modality to noninvasively scan the whole body for diagnosing, staging and assessing response to therapy in various benign and malignant diseases. 18F fluorodeoxyglucose (FDG) is the most commonly used radiotracer for PET/CT imaging in cancer patients. FDG is a glucose analogue which is the predominant substrate for brain metabolism. As the brain cells are obligate glucose consumers, the knowledge of physiologic radiotracer uptake within the brain is imperative for correct interpretation of abnormal sites of metabolism...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28711736/two-dose-investigation-of-the-5-ht-agonist-psilocybin-on-relative-and-global-cerebral-blood-flow
#7
Candace R Lewis, Katrin H Preller, Rainer Kraehenmann, Lars Michels, Philipp Stämpfli, Franz X Vollenweider
Psilocybin, the active compound in psychedelic mushrooms, is an agonist of various serotonin receptors. Seminal psilocybin positron emission tomography (PET) research suggested regional increases in glucose metabolism in frontal cortex (hyperfrontality). However, a recent arterial spin labeling (ASL) study suggests psilocybin may lead to hypo-perfusion in various brain regions. In this placebo-controlled, double-blind study we used pseudo-continuous ASL (pCASL) to measure perfusion changes, with and without adjustment for global brain perfusion, after two doses of oral psilocybin (low dose: 0...
July 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28710347/effects-of-lipoic-acid-on-high-fat-diet-induced-alteration-of-synaptic-plasticity-and-brain-glucose-metabolism-a-pet-ct-and-13-c-nmr-study
#8
Zhigang Liu, Ishan Patil, Harsh Sancheti, Fei Yin, Enrique Cadenas
High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival, learning, and memory. Lipoic acid is known to modulate the redox status of the cell and has insulin mimetic effects. This study was aimed at determining the effects of dietary administration of lipoic acid on a HFD-induced obesity model in terms of (a) insulin signaling, (b) brain glucose uptake and neuronal- and astrocytic metabolism, and (c) synaptic plasticity...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710138/disruption-of-lipid-uptake-in-astroglia-exacerbates-diet-induced-obesity
#9
Yuanqing Gao, Clarita Layritz, Beata Legutko, Thomas O Eichmann, Elise Laperrousaz, Valentine S Moullé, Celine Cruciani-Guglielmacci, Christophe Magnan, Serge Luquet, Stephen C Woods, Robert H Eckel, Chun-Xia Yi, Cristina Garcia-Caceres, Matthias H Tschöp
Neuronal circuits in the brain help to control feeding behavior and systemic metabolism in response to afferent nutrient and hormonal signals. Although astrocytes have historically been assumed to be less relevant for such neuroendocrine control, we asked whether lipid uptake via lipoprotein lipase (LPL) in astrocytes is required for the central regulation of energy homeostasis. Ex vivo studies with hypothalamic-derived astrocytes showed that LPL expression is up-regulated by oleic acid; whereas it is decreased in response to palmitic acid or triglyceride...
July 14, 2017: Diabetes
https://www.readbyqxmd.com/read/28709994/metabolic-correction-by-pyruvate-halts-acquired-epilepsy-in-multiple-rodent-models
#10
I Popova, A Malkov, A I Ivanov, E Samokhina, S Buldakova, O Gubkina, A Osypov, T Zilberter, M Molchanov, S Paskevich, M Zilberter, Y Zilberter
Metabolic intervention strategy of epilepsy treatment has been gaining broader attention due to accumulated evidence that hypometabolism, manifested in humans as reduced brain glucose consumption, is a principal factor in acquired epilepsy. Therefore, targeting deficient energy metabolism may be an effective approach for treating epilepsy. To confront this pathology we utilized pyruvate, which besides being an anaplerotic mitochondrial fuel possesses a unique set of neuroprotective properties as it: (i) is a potent reactive oxygen species scavenger; (ii) abates overactivation of Poly [ADP-ribose] polymerase 1 (PARP-1); (iii) facilitates glutamate efflux from the brain; (iv) augments brain glycogen stores; (v) is anti-inflammatory; (vi) prevents neuronal hyperexcitability; and (vii) normalizes the cytosolic redox state...
July 11, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28709938/a-cross-sectional-comparison-of-brain-glucose-and-ketone-metabolism-in-cognitively-healthy-older-adults-mild-cognitive-impairment-and-early-alzheimer-s-disease
#11
E Croteau, C A Castellano, M Fortier, C Bocti, T Fulop, N Paquet, S C Cunnane
INTRODUCTION: Deteriorating brain glucose metabolism precedes the clinical onset of Alzheimer's disease (AD) and appears to contribute to its etiology. Ketone bodies, mainly β-hydroxybutyrate and acetoacetate, are the primary alternative brain fuel to glucose. Some reports suggest that brain ketone metabolism is unchanged in AD but, to our knowledge, no such data are available for MCI. OBJECTIVE: To compare brain energy metabolism (glucose and acetoacetate) and some brain morphological characteristics in cognitively healthy older adult controls (CTL), mild cognitive impairment (MCI) and early AD...
July 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28706476/long-term-sex-dependent-vulnerability-to-metabolic-challenges-in-prenatally-stressed-rats
#12
Pamela Panetta, Alessandra Berry, Veronica Bellisario, Sara Capoccia, Carla Raggi, Alessia Luoni, Linda Longo, Marco A Riva, Francesca Cirulli
Prenatal stress (PNS) might affect the developmental programming of adult chronic diseases such as metabolic and mood disorders. The molecular mechanisms underlying such regulations may rely upon long-term changes in stress-responsive effectors such as Brain-Derived Neurotrophic Factor (BDNF) that can affect neuronal plasticity underlying mood disorders and may also play a role in metabolic regulation. Based upon previous data, we hypothesized that PNS might lead to greater vulnerability to an obesogenic challenge experienced at adulthood...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28705919/time-courses-of-cortical-glucose-metabolism-and-microglial-activity-across-the-life-span-of-wild-type-mice-a-pet-study
#13
Matthias Brendel, Carola Focke, Tanja Blume, Finn Peters, Maximilian Deussing, Federico Probst, Anna Jaworska, Felix Overhoff, Nathalie Albert, Simon Lindner, Barbara von Ungern-Sternberg, Peter Bartenstein, Christian Haass, Gernot Kleinberger, Jochen Herms, Axel Rominger
Contrary to findings in human brain, [(18)F]-FDG PET shows cerebral hypermetabolism of aged wild-type (WT) mice relative to younger animals, supposedly due to microglial activation. Therefore, we used dual tracer µPET to examine directly the link between neuroinflammation and hypermetabolism in aged mice. Methods: WT mice (5-20 months) were investigated in a cross-sectional design using [(18)F]-FDG (N = 43) and TSPO ([(18)F]-GE180; N = 58) µPET, with volume-of-interest and voxel-wise analyses. Biochemical analysis of plasma cytokine levels and immunohistochemical confirmation of microglial activity were also performed...
July 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28705754/progression-of-lyme-disease-to-bell-s-palsy-despite-treatment-with-doxycycline
#14
Luis A Marcos, Zengmin Yan
A 54 year-old healthy woman presented to the emergency department with a right sided facial paralysis. About 3 weeks ago, she woke up and noticed an attached engorged tick in her right lower extremity. A week later, she noticed a mild to moderate right jaw pain which progressed to a severe right facial pain so she visited her doctor. On physical, II to XII cranial nerve examination was unremarkable. Doppler ultrasound did not show any vascular abnormalities in temporal artery. Her inflammatory markers were within normal limits (C-reactive protein:0...
July 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28704562/cerebral-18f-fdg-pet-in-macrophagic-myofasciitis-an-individual-svm-based-approach
#15
Paul Blanc-Durand, Axel Van Der Gucht, Eric Guedj, Mukedaisi Abulizi, Mehdi Aoun-Sebaiti, Lionel Lerman, Antoine Verger, François-Jérôme Authier, Emmanuel Itti
INTRODUCTION: Macrophagic myofasciitis (MMF) is an emerging condition with highly specific myopathological alterations. A peculiar spatial pattern of a cerebral glucose hypometabolism involving occipito-temporal cortex and cerebellum have been reported in patients with MMF; however, the full pattern is not systematically present in routine interpretation of scans, and with varying degrees of severity depending on the cognitive profile of patients. Aim was to generate and evaluate a support vector machine (SVM) procedure to classify patients between healthy or MMF 18F-FDG brain profiles...
2017: PloS One
https://www.readbyqxmd.com/read/28699407/hydrogen-sulfide-and-glucose-homeostasis-a-tale-of-sweet-the-stink
#16
Ashley Untereiner, Lingyun Wu
SIGNIFICANCE: Among many endogenous mediators, the gasotransmitter hydrogen sulfide (H2S) plays an important role in the regulation of glucose homeostasis. Here we discuss different functional roles of H2S in several metabolic organs/tissues required in the maintenance of glucose homeostasis. Recent Advances: New evidence has emerged revealing the insulin sensitizing role of H2S in adipose tissue and skeletal muscle biology. Additionally, H2S was demonstrated to be a potent stimulator of gluconeogenesis via the induction and stimulation of various glucose-producing pathways in the liver...
July 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28697557/comparison-of-different-hypotheses-regarding-the-spread-of-alzheimer-s-disease-using-markov-random-fields-and-multimodal-imaging
#17
Martin Dyrba, Michel J Grothe, Abdolreza Mohammadi, Harald Binder, Thomas Kirste, Stefan J Teipel
Alzheimer's disease (AD) is characterized by a cascade of pathological processes that can be assessed in vivo using different neuroimaging methods. Recent research suggests a systematic sequence of pathogenic events on a global biomarker level, but little is known about the associations and dependencies of distinct lesion patterns on a regional level. Markov random fields are a probabilistic graphical modeling approach that represent the interaction between individual random variables by an undirected graph...
July 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28689143/glial-cell-line-derived-neurotrophic-factor-gdnf-serum-level-in-women-with-schizophrenia-and-depression-correlation-with-clinical-and-metabolic-parameters
#18
Maria Skibinska, Pawel Kapelski, Joanna Pawlak, Aleksandra Rajewska-Rager, Monika Dmitrzak-Weglarz, Aleksandra Szczepankiewicz, Piotr Czerski, Joanna Twarowska-Hauser
AIM: Neurotrophic factors have been implicated in neuropsychiatric disorders, including schizophrenia and depression. Glial Cell Line-Derived Neurotrophic Factor (GDNF) promotes development, differentiation, and protection of dopaminergic, serotonergic, GABAergic and noradrenergic neurons as well as glial cells in different brain regions. This study examined serum levels of GDNF in schizophrenia and depression and its correlation with metabolic parameters during 8 weeks of treatment. METHODS: Serum GDNF level, fasting serum glucose and lipid profile were measured at baseline and week 8 in 133 women: 55 with schizophrenia, 30 with a first episode depression and 48 healthy controls...
July 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28688899/central-insulin-dysregulation-and-energy-dyshomeostasis-in-two-mouse-models-of-alzheimer-s-disease
#19
Ramon Velazquez, An Tran, Egide Ishimwe, Larry Denner, Nikhil Dave, Salvatore Oddo, Kelly T Dineley
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide. While the causes of AD are not known, several risk factors have been identified. Among these, type two diabetes (T2D), a chronic metabolic disease, is one of the most prevalent risk factors for AD. Insulin resistance, which is associated with T2D, is defined as diminished or absent insulin signaling and is reflected by peripheral blood hyperglycemia and impaired glucose clearance. In this study, we used complementary approaches to probe for peripheral insulin resistance, central nervous system (CNS) insulin sensitivity and energy homeostasis in Tg2576 and 3xTg-AD mice, two widely used animal models of AD...
June 17, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28688822/visual-food-cues-decrease-postprandial-glucose-concentrations-in-lean-and-obese-men-without-affecting-food-intake-and-related-endocrine-parameters
#20
Swantje Brede, Annika Sputh, Ann-Christin Hartmann, Manfred Hallschmid, Hendrik Lehnert, Johanna Klement
The abundance of highly palatable food items in our environment represents a possible cause of overconsumption. Neuroimaging studies in humans have demonstrated that watching pictures of food increases activation in brain areas involved in homeostatic and hedonic food cue processing. Nevertheless, the impact of food cues on actual food intake and metabolic parameters has not been systematically investigated. We tested the hypothesis that watching high-calorie food cues increases food intake and modifies anticipatory blood parameters in lean and especially in obese men...
July 5, 2017: Appetite
keyword
keyword
15160
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"