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https://www.readbyqxmd.com/read/28647176/mitochondrial-oxidative-phosphorylation-efficiency-is-upregulated-during-fasting-in-two-major-oxidative-tissues-of-ducklings
#1
Pierre-Axel Monternier, Loïc Teulier, Jocelyne Drai, Aurore Bourguignon, Delphine Collin-Chavagnac, Frédéric Hervant, Jean-Louis Rouanet, Damien Roussel
Fasted endothermic vertebrates must develop physiological responses to maximize energy conservation and survival. The aim of this study was to determine the effect of 1-wk. fasting in 5-wk. old ducklings (Cairina moschata) from whole-body resting metabolic rate and body temperature to metabolic phenotype of tissues and mitochondrial coupling efficiency. At the level of whole organism, the mass-specific metabolic rate of ducklings was decreased by 40% after 1-wk. of fasting, which was associated with nocturnal Tb declines and shallow diurnal hypothermia during fasting...
June 21, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28646031/metabolism-and-acetylation-contribute-to-leucine-mediated-inhibition-of-cardiac-glucose-uptake
#2
Edith Renguet, Audrey Ginion, Roselle Gélinas, Laurent Bultot, Julien Auquier, Isabelle Robillard Frayne, Caroline Daneault, Jean-Louis Vanoverschelde, Christine Des Rosiers, Louis Hue, Sandrine Horman, Christophe Beauloye, Luc Bertrand
High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells suggest that leucine alters the insulin response for glucose transport by activating an insulin-negative feedback loop driven by the mammalian target of rapamycin/p70 ribosomal S6 kinase (mTOR/p70S6K) pathway. Here, we examined the molecular mechanism involved in leucine's action on cardiac glucose uptake. Leucine was indeed able to curb glucose uptake after insulin stimulation in both cultured cardiomyocytes and perfused hearts...
June 23, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28644031/tris-cyclopentadienyl-lanthanide-complexes-as-catalysts-for-hydroboration-reaction-toward-aldehydes-and-ketones
#3
Sufang Chen, Dandan Yan, Mingqiang Xue, Yubiao Hong, Yingming Yao, Qi Shen
It was found that homoleptic cyclopentadienyl lanthanide complexes Cp3Ln (Ln = Y (1), Yb (2), Sm (3), Nd (4), La (5), Cp = cyclopentadienyl) can be employed as excellent catalysts for the hydroboration of various aldehydes and ketones toward pinacolborane. These robust lanthanide catalysts exhibited high reactivity with low catalyst loadings (0.01-1 mol %) under mild conditions and good functional group tolerability. These complexes also demonstrated uniquely carbonyl-selective hydroboration in the presence of alkenes and alkynes...
June 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28640998/oximes-and-hydrazones-in-bioconjugation-mechanism-and-catalysis
#4
Dominik K Kölmel, Eric T Kool
The formation of oximes and hydrazones is employed in numerous scientific fields as a simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as diverse as polymer chemistry, biomaterials and hydrogels, dynamic combinatorial chemistry, organic synthesis, and chemical biology. Here we outline chemical developments in this field, with special focus on the past ∼10 years of developments. Recent strategies for installing reactive carbonyl groups and α-nucleophiles into biomolecules are described...
June 22, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28640624/synthesis-of-4-acylpyrazoles-from-saturated-ketones-and-hydrazones-featured-with-multiple-c-sp3-h-bond-functionalization-c-c-bond-cleavage-and-re-organization
#5
Miaomiao Tian, Xiaonan Shi, Xinying Zhang, Xuesen Fan
In this paper, an efficient and convenient one-pot synthesis of diversely substituted 4-acylpyrazole derivatives via copper-catalyzed one pot cascade reactions of saturated ketones with hydrazones is reported. Mechanistically, the formation of the title compounds involves the in situ formation of an enone intermediate through the dehydrogenation of saturated ketone, and the [2+3] cyclization of enone with hydrazone followed by an aromatization-driven C-C bond cleavage and re-organization. To our knowledge, this should be the first example in which the biologically and pharmaceutically important yet otherwise difficult-to-obtain 4-acylpyrazole derivatives were directly prepared from saturated ketones and hydrazones featured with multiple aliphatic C-H bond functionalization, C-C bond cleavage and re-organization...
June 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28640609/enantioselective-copper-catalyzed-arylation-driven-semi-pinacol-rearrangement-of-allylic-alcohols-with-diaryliodonium-salts
#6
Daniel H Lukamto, Matthew J Gaunt
A copper-catalyzed enantioselective arylative semi-pinacol rearrangement of allylic alcohols using diaryliodonium salts is reported. Chiral Cu(II)-bisoxazoline catalysts initiate an electrophilic alkene arylation, triggering a 1,2-alkyl migration to afford a range of non-racemic spirocyclic ketones with high yields, diastero- and enantioselectivities.
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28640461/dynamic-kinetic-spiroketalization-oxa-michael-addition-cascade-of-alkoxyboronates-and-peroxy-acetals-enantio-and-diastereo-selective-synthesis-of-benzannulated-spiroketals
#7
Prasanta Ghorai, Abhisek Midya, Sanjay Maity
A unified dynamic kinetic spiroketalization/ enantioselective oxa-Michael addition cascade of an aromatic ketone tethered to an alkoxyboronate and an enone moiety has been developed using cinchona alkaloid based amino-thiourea/-squaramide organocatalysts to provide isobenzofuran based benzannulated spiroketals with high diastereoselectivities and excellent enantioselectivities. Further, a dynamic kinetic peroxy-hemiacetalization/dynamic kinetic spiroketalization/ enantioselective oxa-Michael addition cascade of above substrates provides the corresponding exo-peroxy benzannulated spiroketals with outstanding enantio- and diastereo-selectivities...
June 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28638409/differential-fasting-plasma-glucose-and-ketone-body-levels-in-ghrko-versus-3xtg-ad-mice-a-potential-contributor-to-aging-related-cognitive-status
#8
Chelsea M Griffith, Lauren N Macklin, Andrzej Bartke, Peter R Patrylo
Cognitive function declines with age and appears to correlate with decreased cerebral metabolic rate (CMR). Caloric restriction, an antiaging manipulation that extends life-span and can preserve cognitive function, is associated with decreased glucose uptake, decreased lactate levels, and increased ketone body (KB) levels in the brain. Since the majority of brain nutrients come from the periphery, this study examined whether the capacity to regulate peripheral glucose levels and KB production differs in animals with successful cognitive aging (growth hormone receptor knockouts, GHRKOs) versus unsuccessful cognitive aging (the 3xTg-AD mouse model of Alzheimer's disease)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28637015/differential-metabonomic-profiles-of-primary-hepatocellular-carcinoma-tumors-from-alcoholic-liver-disease-hbv-infected-and-hcv-infected-cirrhotic-patients
#9
Ding Cao, Can Cai, Mingxin Ye, Junhua Gong, Menghao Wang, Jinzheng Li, Jianping Gong
Our objective was to comparatively profile the metabolite composition of primary hepatocellular carcinoma (HCC) tumors from alcoholic liver disease (ALD), hepatitis B virus (HBV)-infected, and hepatitis C virus (HCV)-infected cirrhotic patients. Primary HCC tumors were collected from ALD, HBV-infected, and HCV-infected cirrhotic patients (n=20 each). High-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy and metabonomic data analysis were performed to compare HCC tumors from the three groups...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636380/a-free-radical-promoted-copper-catalyzed-decarboxylative-alkylation-of-%C3%AE-%C3%AE-unsaturated-carboxylic-acids-with-ich2cf3-and-its-analogues
#10
Yan Zhu, Juwen Gong, Yonghui Wang
A novel and efficient free radical promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogues has been developed. This methodology provides with a convenient access to the synthesis of allylic trifluoromethyl and β-CF3 ketone containing compounds as well as other biologically useful fluorinated molecules and materials.
June 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28636366/oxygenation-via-c-h-c-c-bond-activation-with-molecular-oxygen
#11
Yu-Feng Liang, Ning Jiao
The selective oxidation of organic molecules is a fundamentally important component of modern synthetic chemistry. In the past decades, direct oxidative C-H and C-C bond functionalization has proved to be one of the most efficient and straightforward methods to synthesize complex products from simple and readily available starting materials. Among these oxidative processes, the use of molecular oxygen as a green and sustainable oxidant has attracted considerable attention because of its highly atom-economical, abundant, and environmentally friendly characteristics...
June 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28632963/metal-ion-induced-in-situ-ligand-oxidation-for-self-assembled-clusters-from-bis-5-2-pyridine-2-yl-1-2-4-triazole-3-yl-methane-to-alcohol-or-ketone
#12
Wei-Quan Lin, Yuan-Yuan Peng, Lang Tong, Jian-Hua Jia, Jun-Liang Liu, Yan-Cong Chen, Wen-Bin Chen, Ming-Liang Tong
Hydrothermal reactions of metal nitrates and ligand bis(5-(pyridine-2-yl)-1,2,4-triazol-3-yl)methane (H2L1) on same condition gave three cluster compounds, {Cr2}, {Zn12} and {Fe8}. Notably, methylene group of H2L1 was in situ oxidized either to hydroxymethylated (L2-O)3- in the metallo-ring {Zn12} or to a rigid carbonylated (L3=O)2- in the screw-type {Fe8}. In light of comparative experiment results, NO3- was deduced to be of a catalytic role in ligand oxidation. Metal ions could be regarded as an "induced" tool for clusters generation in self-assembly process...
June 20, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28632549/biomechanical-investigation-of-a-novel-revision-device-in-an-osteoporotic-model-pullout-strength-of-pedicle-screw-anchor-versus-larger-screw-diameter
#13
Jacinto Manon, Mir M Hussain, Jonathan Harris, Mark Moldavsky, Frank La Marca, Brandon S Bucklen
STUDY DESIGN: In vitro cadaveric biomechanical study. OBJECTIVE: To assess revision pullout strength of novel anchored screws (AS) versus conventional larger diameter traditional pedicle screws (TPS) in an osteoporotic model. SUMMARY OF BACKGROUND DATA: Pedicle screws are the most ubiquitous method of treating spinal pathologies requiring lumbar fusion. Although these screws are effective in providing 3-column stabilization of the spine, revision surgeries are occasionally necessary, particularly for geriatric and osteoporotic populations...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28631877/identification-of-chemical-components-in-baidianling-capsule-based-on-gc-ms-and-hplc-combined-with-fourier-transform-ion-cyclotron-resonance-mass-spectrometry
#14
Wenying Wu, Yu Chen, Binjie Wang, Xiaoyang Sun, Ping Guo, Xiaohui Chen
Baidianling Capsule, which is made from 16 Chinese herbs, has been widely used for treating vitiligo clinically. In this study, the sensitive and rapid method has been developed for the analysis of chemical components in Baidianling Capsule by gas chromatography with mass spectrometry in combination with retention indices and high-performance liquid chromatography combined with Fourier transform-ion cyclotron resonance mass spectrometry. Firstly, a total of 110 potential volatile compounds obtained from different extraction procedures including alkanes, alkenes, alkyne, ketones, ethers, aldehydes, alcohols, phenols, organic acids, esters, furan, pyrrole, acid amide, heterocycle and oxide were detected from Baidianling Capsule by gas chromatography with mass spectrometry, of which 75 were identified by mass spectrometry in combination with the retention index...
June 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28631071/oxidation-of-c18-hydroxy-polyunsaturated-fatty-acids-to-epoxide-or-ketone-by-catalase-related-hemoproteins-activated-with-iodosylbenzene
#15
Tarvi Teder, William E Boeglin, Alan R Brash
Small catalase-related hemoproteins with a facility to react with fatty acid hydroperoxides were examined for their potential mono-oxygenase activity when activated using iodosylbenzene. The proteins tested were a Fusarium graminearum 41 kD catalase hemoprotein (Fg-cat, gene FGSG_02217), a Pseudomonas fluorescens Pfl01 catalase (37.5 kD, accession number WP_011333788.1), and a Mycobacterium avium ssp. paratuberculosis 33 kD catalase (gene MAP-2744c). 13-Hydroxy-octadecenoic acids (which are normally unreactive) were selected as substrates because these enzymes react specifically with the corresponding 13S-hydroperoxides (Pakhomova et al...
June 19, 2017: Lipids
https://www.readbyqxmd.com/read/28629090/low-temperature-direct-heterogeneous-bonding-of-polyether-ether-ketone-and-platinum
#16
Weixin Fu, Akitsu Shigetou, Shuichi Shoji, Jun Mizuno
Direct heterogeneous bonding between polyether ether ketone (PEEK) and Pt was realized at the temperatures lower than 150°C. In order to create sufficient bondability to diverse materials, the surface was modified by vacuum ultraviolet (VUV) irradiation, which formed hydrate bridges. For comparison, direct bonding between surfaces atomically cleaned via Ar fast atom bombardment (FAB) was conducted in a vacuum. The VUV irradiation was found to be effective for creating an ultrathin hydrate bridge layer from the residual water molecules in the chamber...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629028/physicochemical-and-biological-assessment-of-peek-composites-embedding-natural-amorphous-silica-fibers-for-biomedical-applications
#17
Patrícia R Monich, Fernanda V Berti, Luismar M Porto, Bruno Henriques, Antonio P Novaes de Oliveira, Márcio C Fredel, Júlio C M Souza
The main aim of this study was to assess the physicochemical and biological properties of a novel poly(ether ether ketone) (PEEK) composite containing 30%wt natural amorphous silica fibers (NASF). PEEK and NASF powders were previously functionalized by atomization and citric acid in order to enhance adhesion between polymeric matrix and fillers. Then, composites were produced by cold compression molding technique at 350°C for 3h. Materials were characterized by chemical, microstructural, thermophysical, mechanical and cytotoxic analysis...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627547/probing-the-electronic-structure-of-a-copper-ii-complex-by-cw-and-pulse-epr-spectroscopy
#18
Zoi G Lada, Yiannis Sanakis, Catherine P Raptopoulou, Vassilis Psycharis, Spyros P Perlepes, George Mitrikas
Nucleophilic attack by the carbanion (-):CH2COCH3 at the carbonyl group of di-2-pyridyl ketone, (py)2CO, in the presence of Cu(II) under moderately basic conditions has yielded the cationic mononuclear complex [Cu{(py)2C(CH2COCH3)(OH)}2](NO3)2·2H2O (1·2H2O) in ∼40% yield, where (py)2C(CH2COCH3)(OH) is the ligand bis(2-pyridine-2-yl)butane-1-ol-3-one. The Cu(II) atom of the cation sits on a crystallographically imposed inversion center. The neutral molecule is coordinated to the metal ion as a tridentate fac chelating ligand through the hydroxyl oxygen atom and two 2-pyridyl nitrogen atoms...
June 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28627374/characterization-of-the-concurrent-metabolic-changes-in-brain-and-plasma-during-insulin-induced-moderate-hypoglycemia-using-1-h-nmr-spectroscopy-in-juvenile-rats
#19
Kathleen Ennis, Elizabeth Lusczek, Raghavendra Rao
Treatment of hypoglycemia in children is currently based on plasma glucose measurements. This approach may not ensure neuroprotection since plasma glucose does not reflect the dynamic state of cerebral energy metabolism. To determine whether cerebral metabolic changes during hypoglycemia could be better characterized using plasma metabolomic analysis, insulin-induced acute hypoglycemia was induced in 4-week-old rats. Brain tissue and concurrent plasma samples were collected from hypoglycemic (N=7) and control (N=7) rats after focused microwave fixation to prevent post-mortem metabolic changes...
June 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28627009/iron-catalyzed-radical-decarboxylative-oxyalkylation-of-terminal-alkynes-with-alkyl-peroxides
#20
Xiaotao Zhu, Changqing Ye, Yajun Li, Hongli Bao
We report an iron-catalyzed oxyalkylation of alkynes with alkyl peroxides as the alkylating reagents. Alkyl peroxides are readily available from aliphatic acids and serve simultaneously as the alkylating reagents and internal oxidants. Primary, secondary, and tertiary alkyl groups of aliphatic acids were readily incorporated into C-C triple bonds and diverse α-alkylated ketones were synthesized. Mechanism studies revealed that this reaction involves highly reactive alkyl free radicals. A unique equilibrium between lauric acid and water catalyzed by the iron(III) catalyst was observed...
June 18, 2017: Chemistry: a European Journal
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