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https://www.readbyqxmd.com/read/28340340/selective-chemical-inhibition-of-pgc-1%C3%AE-gluconeogenic-activity-ameliorates-type-2-diabetes
#1
Kfir Sharabi, Hua Lin, Clint D J Tavares, John E Dominy, Joao Paulo Camporez, Rachel J Perry, Roger Schilling, Amy K Rines, Jaemin Lee, Marc Hickey, Melissa Bennion, Michelle Palmer, Partha P Nag, Joshua A Bittker, José Perez, Mark P Jedrychowski, Umut Ozcan, Steve P Gygi, Theodore M Kamenecka, Gerald I Shulman, Stuart L Schreiber, Patrick R Griffin, Pere Puigserver
Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver, a chemical modification known to inhibit hepatic gluconeogenesis, could be potentially used for treatment of T2D. Thus, we designed a high-throughput chemical screen platform to quantify PGC-1α acetylation in cells and identified small molecules that increase PGC-1α acetylation, suppress gluconeogenic gene expression, and reduce glucose production in hepatocytes...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28340302/does-the-type-of-activity-break-from-prolonged-sitting-differentially-impact-on-post-prandial-blood-glucose-reductions-an-exploratory-analysis
#2
Robyn N Larsen, Paddy C Dempsey, Francis Dillon, Megan Grace, Bronwyn A Kingwell, Neville Owen, David W Dunstan
Frequent breaks in prolonged sitting are associated beneficially with glycaemic control. However, the contribution of energy expenditure to these relationships has not been well characterised. In this exploratory analysis, data from three laboratory trials that standardised test meals, cohort characteristics (overweight/obese, sedentary), and break frequency and duration were pooled. Higher energy expenditures of different types of breaks (standing, light- or moderate-intensity walking) were associated with lower post-prandial glucose and insulin responses in a dose-dependent manner...
March 24, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28340043/very-long-term-outcome-following-transcatheter-ablation-of-atrial-fibrillation-are-results-maintained-after-10-years-of-follow-up
#3
Fiorenzo Gaita, Marco Scaglione, Alberto Battaglia, Mario Matta, Cristina Gallo, Michela Galatà, Domenico Caponi, Paolo Di Donna, Matteo Anselmino
Aims: Atrial fibrillation (AF) transcatheter ablation is a safe and effective procedure. However, outcome over 10 years of follow-up has never been reported. The aim of this study is to assess outcome, describe predictors of recurrences, and report on quality of life (QoL) the decade after an AF ablation. Methods and results: Patients referred for AF ablation in a single high volume centre from June 2004 to June 2006 were enrolled and followed in a prospective fashion by yearly clinical assessment and Holter monitoring...
February 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339953/genotype-phenotype-associations-for-low-glucose-6-phosphate-dehydrogenase-activity-in-red-blood-cells
#4
Jennifer Powers, Hunter Best, David Grenache
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28339485/chronic-parp-1-inhibition-reduces-carotid-vessel-remodeling-and-oxidative-damage-of-the-dorsal-hippocampus-in-spontaneously-hypertensive-rats
#5
Krisztian Eros, Klara Magyar, Laszlo Deres, Arpad Skazel, Adam Riba, Zoltan Vamos, Tamas Kalai, Ferenc Gallyas, Balazs Sumegi, Kalman Toth, Robert Halmosi
Vascular remodeling during chronic hypertension may impair the supply of tissues with oxygen, glucose and other compounds, potentially unleashing deleterious effects. In this study, we used Spontaneously Hypertensive Rats and normotensive Wistar-Kyoto rats with or without pharmacological inhibition of poly(ADP-ribose)polymerase-1 by an experimental compound L-2286, to evaluate carotid artery remodeling and consequent damage of neuronal tissue during hypertension. We observed elevated oxidative stress and profound thickening of the vascular wall with fibrotic tissue accumulation induced by elevated blood pressure...
2017: PloS One
https://www.readbyqxmd.com/read/28339051/protective-effects-of-tacrolimus-on-podocytes-in-early-diabetic-nephropathy-in-rats
#6
Tao Peng, Xiangdi Chang, Jie Wang, Junhui Zhen, Xiangdong Yang, Zhao Hu
The aim of the present study was to investigate the protective effect of tacrolimus on early podocyte damage in rats with diabetic nephropathy (DN). A total of 38 normal male Sprague‑Dawley rats were randomly divided into four groups: Normal control group (group N; n=8), DN group (n=10), tacrolimus (FK506) treatment group (group F; n=10), benazepril (Lotensin) treatment group (group L; n=10). The rats in groups DN, F and L were administered with streptozotocin (STZ; 60 mg/kg) by intraperitoneal injection to establish the diabetic rat model...
March 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338880/the-yield-and-feasibility-of-integrated-screening-for-tb-diabetes-and-hiv-in-four-public-hospitals-in-ethiopia
#7
Degu Jerene, Nebiyu Hiruy, Ilili Jemal, Wondimu Gebrekiros, Tadesse Anteneh, Dereje Habte, Muluken Melese, Pedro Suarez, Gloria Sangiwa
Background: Our objective was to demonstrate the feasibility of integrated care for TB, HIV and diabetes mellitus (DM) in a pilot project in Ethiopia. Methods: Healthcare workers in four hospitals screened patients with TB for HIV and DM; patients with HIV for DM and TB; and patients with DM for TB. Fasting and random plasma glucose (RPG) tests were used to confirm the diagnosis of DM. We used screening checklists for TB and DM, and additional risk scoring criteria to identify patients at risk of DM...
March 2, 2017: International Health
https://www.readbyqxmd.com/read/28338809/resveratrol-derivative-btm-0512-mitigates-obesity-by-promoting-beige-remodeling-of-subcutaneous-preadipocytes
#8
Qingqing Li, Kuansong Wang, Yipeng Ma, Chunxiang Qin, Changsheng Dong, Ping Jin, Yan Wu, Xiaoming Xiong, Niansheng Li, Changping Hu, Jun Peng, Zhichun Yang
Recent studies revealed that sirtuin 1 (SIRT1) is involved in the regulation of energy metabolism and its agonist resveratrol showed anti-obesity effect. This study aims to determine whether BTM-0512, a novel derivative of resveratrol, acts as an antagonist of obesity and to explore its possible mechanisms. High-fat diet (HFD)-induced obese mice were intragastrically administered with BTM-0512 (5, 10, and 20 mg/kg/day) or resveratrol (10 mg/kg/day). It was found that the body weight, Lee's index, ratio of visceral adipose tissue (VAT) to body weight, and blood glucose were significantly reduced in BTM-0512-treated mice when compared with those in mice treated with resveratrol...
February 24, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28338771/blood-pressure-control-during-chronic-kidney-disease-progression
#9
Seulbi Lee, Hyung Jung Oh, Eun-Kyung Lee, Oesook Lee, Eunhee Ha, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Dong-Ryeol Ryu
BACKGROUND: Hypertension is a major cause of end-stage renal disease, and blood pressure (BP) control is crucial in patients with chronic kidney disease (CKD). However, it is generally inadequately controlled in CKD patients. We investigated the prevalence of CKD patients with inadequate BP control and its related factors, based on the CKD stage. METHODS: We analyzed the health examination sample cohort database, which consisted of the randomly selected participants among all the citizens who received the health examination provided by National Health Insurance Service of Korea in 2012 and 2013...
February 16, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28338477/osmotic-and-hemodynamic-effects-of-hypertonic-glucose-during-hemodialysis
#10
Daniel Schneditz, Stanisław Niemczyk, Notburga Sauseng, Isolde Bachler, Edda Zierler, Helmut Karl Lackner, Hildegard Hafner-Giessauf
It was the purpose to quantify the hemodynamic effects of a bolus of hypertonic glucose injected into the extracorporeal system in a group of stable and non-diabetic patients during hemodialysis (HD).Glucose and electrolytes were measured in frequent intervals. Arterial blood pressures and heart rates were continuously recorded by non-invasive vascular unloading technique. Beat-to-beat stroke volume, cardiac output, and total peripheral resistance were determined by Modelflow method. Relative blood volumes were continuously measured by ultrasonic and optical means...
March 22, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28338216/the-diversified-function-and-potential-therapy-of-ectopic-olfactory-receptors-in-non-olfactory-tissues
#11
REVIEW
Zhe Chen, Hong Zhao, Nian Fu, Linxi Chen
Olfactory receptors (ORs) are mainly distributed in olfactory neurons and play a key role in detecting volatile odorants, eventually resulting in the production of smell perception. Recently, it is also reported that ORs are expressed in non-olfactory tissues including heart, lung, sperm, skin and cancerous tissues. Interestingly, ectopic ORs are associated with the development of diseases in non-olfactory tissues. For instance, ectopic ORs initiate the hypoxic ventilatory responses and maintain the oxygen homeostasis of breathing in the carotid body when oxygen levels decline...
March 24, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28338115/resveratrol-supplementation-in-patients-with-non-alcoholic-fatty-liver-disease-systematic-review-and-meta-analysis
#12
REVIEW
Ahmed Elgebaly, Ibrahim A I Radwan, Mohamed M AboElnas, Hamza H Ibrahim, Moutaz F M Eltoomy, Ahmed A Atta, Hend A Mesalam, Alaa A Sayed, Amr A Othman
BACKGROUND: Resveratrol is a potential treatment option for management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant properties, and calorie restriction-like effects. We aimed to synthesise evidence from published randomized clinical trials (RCTs) about the efficacy of resveratrol in the management of NAFLD. METHODS: A computer literature search of PubMed, Scopus, Web of Science, and Cochrane Central was conducted using relevant keywords...
March 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28338063/greater-postprandial-glucose-excursions-and-inadequate-nutrient-intake-in-youth-with-type-1-diabetes-and-celiac-disease
#13
Anna Pham-Short, Kim C Donaghue, Geoffrey Ambler, Sarah Garnett, Maria E Craig
The gluten free diet (GFD) has a high glycemic index and low-fiber content, which potentially influences glycemic excursions in type 1 diabetes (T1D) and celiac disease (CD). Participants in this case-control study of youth with T1D+CD (n = 10) and T1D only (n = 7) wore blinded continuous glucose monitoring systems for six days. Blood glucose levels (BGLs) were compared between groups for each meal, including pre-meal, peak, 2-hour postprandial and time-to-peak. Participants consumed a test-breakfast of GF cereal and milk for three days and kept weighed food diaries; nutrient intake was analyzed and compared to national recommendations...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337953/influence-of-chronic-exposure-to-simulated-shift-work-on-disease-and-longevity-in-disease-prone-inbred-mice
#14
Linda A Toth Rita A Trammell Teresa Liberati Steve Verhulst Marcia L Hart Jacob E Moskowitz And Craig Franklin
Shift work (SW) is viewed as a risk factor for the development of many serious health conditions, yet prospective studies thatdocument such risks are rare. The current study addressed this void by testing the hypothesis that long-term exposure to repeated diurnal phase shifts, mimicking SW, will accelerate disease onset or death in inbred mice with genetic risk of developing cancer,diabetes, or autoimmune disease. The data indicate that 1) life-long exposure to simulated SW accelerates death in female cancerprone AKR/J mice; 2) a significant proportion of male NON/ShiLtJ mice, which have impaired glucose tolerance but do not normally progress to type 2 diabetes, develop hyperglycemia, consistent with diabetes (that is, blood glucose 250 mg/dL or greater) after exposure to simulated SW for 8 wk; and 3) MRL/MpJ mice, which are prone to develop autoimmune disease, showed sex-related acceleration of disease development when exposed to SW as compared with mice maintained on a stable photocycle...
March 23, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28337877/correlation-between-cystatin-c-and-retinopathy-of-type-two-diabetes-mellitus-patients
#15
C Qian, G M Wan, P S Yan, W Z Wang, S Z Liang, Y Dong
Diabetic retinopathy is one of most common diabetic microvascular complications. In recent years the incidence of the disease has increased, hence early diagnosis and treatment are of great importance. In order to find reliable biological indexes to diagnose and treat type-two diabetes mellitus promptly, this study focused on the correlation between Cystatin C (Cys C) and retinopathy of type-two diabetes mellitus patients. One hundred and eighty type-two diabetes mellitus patients and one hundred healthy controls (the control group) were chosen in this study...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337858/transdermal-protein-delivery-using-choline-and-geranate-cage-deep-eutectic-solvent
#16
Amrita Banerjee, Kelly Ibsen, Yasunori Iwao, Michael Zakrewsky, Samir Mitragotri
Transdermal delivery of peptides and other biological macromolecules is limited due to skin's inherent low permeability. Here, the authors report the use of a deep eutectic solvent, choline and geranate (CAGE), to enhance topical delivery of proteins such as bovine serum albumin (BSA, molecular weight: ≈66 kDa), ovalbumin (OVA, molecular weight: ≈45 kDa) and insulin (INS, molecular weight: 5.8 kDa). CAGE enhances permeation of BSA, OVA, and insulin into porcine skin ex vivo, penetrating deep into the epidermis and dermis...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28337855/simple-protein-modification-using-zwitterionic-polymer-to-mitigate-the-bioactivity-loss-of-conjugated-insulin
#17
Jinbing Xie, Yang Lu, Wei Wang, Hui Zhu, Zhigang Wang, Zhiqiang Cao
Polymer-protein conjugation has been extensively explored toward a better protein drug with improved pharmacokinetics. However, a major problem with polymer-protein conjugation is that the polymers drastically reduce the bioactivity of the modified protein. There is no perfect solution to prevent the bioactivity loss, no matter the polymer is conjugated in a non-site specific way, or a more complex site-specific procedure. Here the authors report for the first time that when zwitterionic carboxybetaine polymer (PCB) is conjugated to insulin through simple conventional coupling chemistry...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28337770/hypoglycemic-effect-of-hawthorn-in-type-ii-diabetes-mellitus-rat-model
#18
Aili Aierken, Tina Buchholz, Chen Chen, Xiaoying Zhang, Matthias F Melzig
BACKGROUND: Hawthorn is one of the popular herbs in many different traditional medicine systems including in Traditional Chinese Medicine (TCM), where it has long been used for the treatment of hyperglycemia. However, most of its varied biological activities are still remaining unexplored. This study investigated the hypoglycemic effect of hawthorn extracts in type II diabetic (T2DM) rat model. A total of 54 rats were randomly divided into six groups. Normal control group (NC), type II diabetic model group (T2DM, T2DM rats were induced by high fat diet and streptozotocin), high, middle and low concentrations of hawthorn treat groups (HTH , HTM and HTL , T2DM rats were given hawthorn extract at the dose of 50, 100 and 200 mg kg ^-1...
March 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28337298/xbp1-lox-axis-is-critical-in-er-stress-induced-growth-of-lung-adenocarcinoma-in-3d-culture
#19
Yi Yang, Bai-Jun Cheng, Hong Jian, Zhi-Wei Chen, Yi Zhao, Yong-Feng Yu, Zi-Ming Li, Mei-Lin Liao, Shun Lu
Rapid growth of tumor cells needs to consume large amounts of oxygen and glucose, due to lack of blood supply within the tumor, cells live in an environment that lack of oxygen and nutrients. This environment results in endoplasmic reticulum (ER) stress and activates the UPR (unfolded protein response). More and more evidence suggests UPR provides a growth signal pathway required for tumor growth. In the present study, we investigated the relationship between XBP1, one transcription factor in UPR, and the expression of LOX...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28336764/anti-hyperglycemic-activity-of-moringa-oleifera-is-partly-mediated-by-carbohydrase-inhibition-and-glucose-fiber-binding
#20
Sohel Bin Azad, Prawej Ansari, Shermin Akter, Saad Mosharraf Hossain, Shofiul Azam, Fahima Faroque Archi, Mahmudul Hasan, Jma Hannan
Background:Moringa oleifera has potential anti-hyperglycemic effects that is reported earlier by different scientific group using animal diabetic models. We aimed to explore the possible mechanism of action of M. oleifera extract through different method. Methods : Primarily we measured Fasting Blood Glucose and performed Glucose Tolerance Test, in type 2 diabetic rats. Further we studied the effect of extracts on pancreatic insulin concentration. Extracts effect on carbohydrate break down was assayed using α-amylase inhibition assays and assay of GI tracts six different segments...
March 23, 2017: Bioscience Reports
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