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https://www.readbyqxmd.com/read/29342445/case-report-of-an-uncommon-case-of-drain-site-hernia-after-colorectal-surgery
#1
M Manigrasso, P Anoldo, F Milone, G D De Palma, M Milone
BACKGROUND: trocar site herniation is a rare but potentially serious complication of laparoscopic surgery. Data about drain site hernia after laparoscopic surgery is scarce and anecdotal. CASE PRESENTATION: we report an uncommon case of drain site hernia in a man undergone laparoscopic left colectomy for a colonic adenocarcinoma who developed small bowel herniation in a 10 mm port site, in which a 24 FR drain was inserted leaving a real free space of 2 mm. DISCUSSION: laparoscopic approach has gained widespread acceptance in each surgical fields because of the perceived better postoperative outcomes in terms of less pain, faster recovery, and lower risk of incisional hernia...
January 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29342321/contributions-of-material-properties-and-structure-to-increased-bone-fragility-for-a-given-bone-mass-in-the-ucd-t2dm-rat-model-of-type-2-diabetes
#2
Claire Acevedo, Meghan Sylvia, Eric Schaible, James L Graham, Kimber L Stanhope, Lionel N Metz, Bernd Gludovatz, Ann V Schwartz, Robert O Ritchie, Tamara N Alliston, Peter J Havel, Aaron J Fields
Adults with type 2 diabetes (T2D) have a higher fracture risk for a given bone quantity, but the mechanisms remain unclear. Using a rat model of polygenic obese T2D, we demonstrate that diabetes significantly reduces whole-bone strength for a given bone mass (micro-CT-derived BMC), and we quantify the roles of T2D-induced deficits in material properties versus bone structure, i.e., geometry and microarchitecture. Lumbar vertebrae and ulnae were harvested from 6-month-old lean Sprague-Dawley rats, obese Sprague-Dawley rats, and diabetic obese UCD-T2DM rats (diabetic for 69 ± 7 days; blood glucose >200 mg/dl)...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29340961/metabolic-syndrome-and-its-components-among-korean-submariners-a-retrospective-cross-sectional-study
#3
Jihun Kang, Yun-Mi Song
PURPOSE: Metabolic syndrome (MetS) is a cluster of inter-related risk factors for cardiovascular disease and diabetes. Although submariners tend to be exposed to unhealthy environmental factors, such as a confined work environment, physical inactivity, and circadian disruption, little is known regarding whether the risks of MetS and its components are associated with submarine service. The present study aimed to evaluate the risks of MetS and its components among submariners. METHODS: A total of 5090 subjects (513 submariners and 4577 non-submariners) were included in the present study...
January 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29340912/predictors-of-hypoglycemia-in-hospitalized-patients-with-diabetes-mellitus
#4
Amit Akirov, Oren Amitai, Hiba Masri-Iraqi, Talia Diker-Cohen, Tzipora Shochat, Yoav Eizenberg, Ilan Shimon
Hypoglycemia is common among hospitalized patients with diabetes mellitus (DM), and is associated with increased morbidity and mortality. Identify pre-admission risk factors associated with in-hospital hypoglycemia. Historical prospectively collected data of adult DM patients hospitalized to medical wards between 2011 and 2013. Hypoglycemia and serious hypoglycemia were defined as at least one blood glucose measurement ≤ 70 and < 54 mg/dl, respectively, during hospitalization. The primary outcome was in-hospital hypoglycemia...
January 16, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29340908/fasting-blood-glucose-level-in-locally-advanced-non-small-cell-lung-cancer-a-new-prognostic-factor
#5
Esra Korkmaz Kirakli, Ufuk Yilmaz, Hasan Yilmaz, Berna Komurcuoglu
Hyperglycemia may lead to proliferation, invasion, apoptosis inhibition, migration, and eventually metastasis of cancer cells by several mechanisms. In this study, the effect of hyperglycemia on overall survival (OS), disease-free survival (DFS), and locoregional recurrence (LRR) was investigated in NSCLC. One stage IIIA-IIIB NSCLC patient treated with chemoradiotherapy between 2010 and 2015 was enrolled. Fasting blood glucose (FBG) levels were recorded in pre-treatment, treatment, and post-treatment periods...
January 16, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29340155/preservation-of-renal-function-by-intensive-glycemic-control
#6
Naoya Toriu, Masayuki Yamanouchi, Rikako Hiramatsu, Noriko Hayami, Junichi Hoshino, Akinari Sekine, Masahiro Kawada, Eiko Hasegawa, Tatsuya Suwabe, Keiichi Sumida, Toshiharu Ueno, Naoki Sawa, Kenichi Ohashi, Takeshi Fujii, Kenmei Takaichi, Motoko Yanagita, Tetsuro Kobayasi, Yoshifumi Ubara
We report the case of a 67-year-old Japanese woman with type 1 diabetes mellitus. At 47 years of age, her hemoglobin A1c (HbA1c) was 10.0%, and she had overt nephropathy. The first renal biopsy yielded a diagnosis of diabetic nephropathy. Intensive glycemic control was initiated and her HbA1c improved to 6.0%. Renal dysfunction showed no progression for 15 years. At 62 years of age, a second renal biopsy was performed. Glomerular lesions did not show progression but tubulointerstitial fibrosis and vascular lesions showed progression compared with the first biopsy...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29340122/a-cross-sectional-study-of-glycemic-status-and-zinc-level-in-patients-with-beta-thalassemia-major
#7
Mohammad Ali Mashhadi, Zahra Sepehri, Zahra Heidari, Mahmoud Ali Kaykhaei, Aliyeh Sargazi, Farhad Kohan, Hanieh Heidari
Background: Endocrinopathies and diabetes mellitus are prevalent in patients with beta-thalassemia major Recently some studies demonstrate a link between low levels of serum zinc level and higher prevalence of diabetes. The aim of this study was to evaluate the glucose tolerance in patients suffered from beta-thalassemia major and determine the association of Homeostasis Model Assessment (HOMA) parameters with zinc status among these patients. Materials andMethods: In this cross sectional study, clinical data of patients who were suffered from thalassemia major, aged≥10 years were collected...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340106/a-maternal-high-fat-diet-during-pregnancy-and-lactation-in-addition-to-a-postnatal-high-fat-diet-leads-to-metabolic-syndrome-with-spatial-learning-and-memory-deficits-beneficial-effects-of-resveratrol
#8
Shih-Wen Li, Hong-Ren Yu, Jiunn-Ming Sheen, Mao-Meng Tiao, You-Lin Tain, I-Chun Lin, Yu-Ju Lin, Kow-Aung Chang, Ching-Chou Tsai, Li-Tung Huang
We tested the hypothesis that high-fat diet consumption during pregnancy, lactation, and/or post weaning, altered the expression of molecular mediators involved in hippocampal synaptic efficacy and impaired spatial learning and memory in adulthood. The beneficial effect of resveratrol was assessed. Dams were fed a rat chow diet or a high-fat diet before mating, during pregnancy, and throughout lactation. Offspring were weaned onto either a rat chow or a high-fat diet. Four experimental groups were generated, namely CC, HC, CH, and HH (maternal chow diet or high-fat diet; postnatal chow diet or high-fat diet)...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340105/long-term-effects-of-sitagliptin-in-patients-with-type-2-diabetes-mellitus-and-hypertension-results-from-the-prologue-study
#9
Ziliang Ye, Hui Li, Haili Lu, Qiang Su, Lang Li
Background: The effects of sitagliptin in patients with type 2 diabetes mellitus and hypertension are unclear. Therefore, we evaluated the long-term effects of sitagliptin in those patients. Methods: In the PROLOGUE study, 365 patients were diagnosed as type 2 diabetes mellitus and hypertension, and 189 patients in the sitagliptin group, 176 patients in the conventional group. Fasting blood glucose (FBG), HbA1c, systolic pressure (SP), diastolic pressure (DP), serum urea nitrogen (BUN) and serum creatinine (SCR) were measured at the beginning of the study and after 12 and 24 months of treatment...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340006/the-impact-of-the-progressive-efficiency-test-on-a-rowing-ergometer-on-white-blood-cells-distribution-and-clinical-chemistry-changes-in-paralympic-rowers-during-the-preparatory-stage-before-the-paralympic-games-in-rio-2016-a-case-report
#10
Robert Nowak, Rafał Buryta, Krzysztof Krupecki, Tomasz Zając, Marek Zawartka, Patrizia Proia, Dorota Kostrzewa-Nowak
There is a large gap in knowledge regarding research on post-exercise blood changes in disabled athletes. There are relatively few data on adaptive mechanisms to exercise in disabled athletes, including disabled rowers. Two rowers from a Polish adaptive rowing settle TAMix2x that qualified for the Paralympic Games in Rio, 2016 took part in this study. They performed a progressive test on a rowing ergometer until exhaustion. The cardiorespiratory fitness measures, complete blood count, white blood cells' distribution and 30 clinical chemistry variables describing laboratory diagnostic profiles and general health were determined...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339986/seeking-optimal-nutrition-for-healthy-body-mass-reduction-among-former-athletes
#11
Dominika Maciejewska, Małgorzata Michalczyk, Maja Czerwińska-Rogowska, Marcin Banaszczak, Karina Ryterska, Karolina Jakubczyk, Jakub Piotrwski, Joanna Hołowko, Arleta Drozd, Paweł Wysokińki, Krzysztof Ficek, Krzysztof Wilk, Anna Lubkowska, Paweł Cięszczyk, Jerzy Bertrand, Ewa Stachowska
The aim of the study was to investigate the efficacy of 6 week Mediterranean diet or 30% calorie restriction on the fatty acid profile and eicosanoids (hydroxyoctadecadienoi acids and hydroxyeicosatetraenoic acids) concentration. Furthermore, basic biochemical variables such as insulin, glucose, HOMA-IR, and a lipid profile were estimated. The study enrolled 94 Caucasian former athletes aged 20-42, with body height of 179 ± 16.00 cm and body mass of 89.26 ± 13.25 kg who had not been active for at least 5 years...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339795/lipidized-prolactin-releasing-peptide-improved-glucose-tolerance-in-metabolic-syndrome-koletsky-and-spontaneously-hypertensive-rat-study
#12
Barbora Mikulášková, Martina Holubová, Veronika Pražienková, Jana Zemenová, Lucie Hrubá, Martin Haluzík, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská
BACKGROUND/OBJECTIVES: Prolactin-releasing peptide (PrRP) has a potential to decrease food intake and ameliorate obesity, but is ineffective after peripheral administration. We have previously shown that our novel lipidized analogs PrRP enhances its stability in the circulation and enables its central effect after peripheral application. The purpose of this study was to explore if sub-chronic administration of novel PrRP analog palmitoylated in position 11 (palm11-PrRP31) to Koletsky-spontaneously hypertensive obese rats (SHROB) could lower body weight and glucose intolerance as well as other metabolic parameters...
January 16, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29339678/endarteritis-of-coarctation-of-the-aorta-diagnosed-with-pet-ct
#13
Ümit Yaşar Sinan, Burcu Dirlik Serim, Rukiye Yıldırım, Özge Çetinarslan, Mehmet Serdar Küçükoğlu
Infective endocarditis (IE) is an infectious disease that affects the endothelium of the large intrathoracic vessels, heart valves, and intra-cardiac foreign body material. A 20-year-old woman was admitted to the cardiology department with complaints of fever and palpitations. Transthoracic echocardiography revealed a bicuspid aortic valve, aortic root enlargement, and aortic coarctation. Transesophageal echocardiography revealed a bicuspid aortic valve, but there was no vegetation. Methicillin-sensitive Staphylococcus aureus was identified on a blood culture...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29339504/complement-pathway-gene-activation-and-rising-circulating-immune-complexes-characterize-early-disease-in-hiv-associated-tuberculosis
#14
Hanif Esmail, Rachel P Lai, Maia Lesosky, Katalin A Wilkinson, Christine M Graham, Stuart Horswell, Anna K Coussens, Clifton E Barry, Anne O'Garra, Robert J Wilkinson
The transition between latent and active tuberculosis (TB) occurs before symptom onset. Better understanding of the early events in subclinical disease will facilitate the development of diagnostics and interventions that improve TB control. This is particularly relevant in the context of HIV-1 coinfection where progression of TB is more likely. In a recent study using [18F]-fluoro-2-deoxy-d-glucose positron emission/computed tomography (FDG-PET/CT) on 35 asymptomatic, HIV-1-infected adults, we identified 10 participants with radiographic evidence of subclinical disease, significantly more likely to progress than the 25 participants without...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29339464/propionate-enters-gabaergic-neurons-inhibits-gaba-transaminase-causes-gaba-accumulation-and-lethargy-in-a-model-of-propionic-acidemia
#15
Cecilie Morland, Anne-Sofie Frøland, Mi Nyguyen Pettersen, Jon Storm-Mathisen, Vidar Gundersen, Frode Rise, Bjørnar Hassel
Propionic acidemia is the accumulation of propionate in blood due to dysfunction of propionyl-CoA carboxylase. The condition causes lethargy and striatal degeneration with motor impairment in humans. How propionate exerts its toxic effect is unclear. Here we show that intravenous administration of propionate causes dose-dependent propionate accumulation in the brain and transient lethargy in mice. Propionate, an inhibitor of histone deacetylase, entered GABAergic neurons, as could be seen from increased neuronal histone H4 acetylation in striatum and neocortex...
January 16, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29339138/hyperglycaemia-disrupts-conducted-vasodilation-in-the-resistance-vasculature-of-db-db-mice
#16
Hamish A L Lemmey, Xi Ye, Hong Ding, Chris R Triggle, Christopher J Garland, Kim A Dora
Vascular dysfunction in small resistance arteries is observed during chronic elevations in blood glucose. Hyperglycaemia-associated effects on endothelium-dependent vasodilation have been well characterized, but effects on conducted vasodilation in the resistance vasculature are not known. Small mesenteric arteries were isolated from healthy and diabetic db/db mice, which were used as a model of chronic hyperglycaemia. Endothelium-dependent vasodilation via the Gq/11-coupled proteinase activated receptor 2 (PAR2) was stimulated with the selective agonist SLIGRL...
January 12, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29339109/bitter-gourd-reduces-elevated-fasting-plasma-glucose-levels-in-an-intervention-study-among-prediabetics-in-tanzania
#17
Michael B Krawinkel, Christine Ludwig, Mark E Swai, Ray-Yu Yang, Kwok Pan Chun, Sandra D Habicht
ETHNOPHARMACOLOGICAL RELEVANCE: Impaired glucose tolerance and diabetes mellitus have become major health issues even in non-industrialized countries. As access to clinical management is often poor, dietary interventions and alternative medicines are required. For bitter gourd, Momordica charantia L., antidiabetic properties have been claimed. AIM OF THE STUDY: The main objective of the intervention study was to assess antidiabetic effects of daily bitter gourd consumption of 2...
January 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29339078/analytical-and-pre-analytical-performance-characteristics-of-a-novel-cartridge-type-blood-gas-analyzer-for-point-of-care-and-laboratory-testing
#18
Matthijs Oyaert, Tom Van Maerken, Silke Bridts, Silvi Van Loon, Heleen Laverge, Veronique Stove
BACKGROUND: Point-of-care blood gas test results may benefit therapeutic decision making by their immediate impact on patient care. We evaluated the (pre-)analytical performance of a novel cartridge-type blood gas analyzer, the GEM Premier 5000 (Werfen), for the determination of pH, partial carbon dioxide pressure (pCO2), partial oxygen pressure (pO2), sodium (Na+), potassium (K+), chloride (Cl-), ionized calcium (iCa2+), glucose, lactate, and total hemoglobin (tHb). METHODS: Total imprecision was estimated according to the CLSI EP5-A2 protocol...
January 12, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29339032/the-relation-between-pro-oxidant-antioxidant-balance-and-glycolipid-profile-6-months-after-gastric-bypass-surgery
#19
Vahideh Banazadeh, Mohsen Nematy, Majid Ghayour Mobarhan, Shima Tavallaie, Habibollah Esmaily, Ali Jangjoo
BACKGROUND: Morbid obesity is a chronic disease that contributes to increased oxidative stress. Gastric bypass surgery is the gold standard method in treating co-morbidities. OBJECTIVES: The objective of this study was to evaluate the relation between pro-oxidant antioxidant balance (PAB) as one measure of oxidative stress and glycolipid profile 6 months after gastric bypass surgery. SETTING: Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran...
December 11, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29338971/atorvastatin-impaired-glucose-metabolism-in-c2c12-cells-partly-via-inhibiting-cholesterol-dependent-glucose-transporter-4-translocation
#20
Binbin Sun, Zeyu Zhong, Fan Wang, Jiong Xu, Feng Xu, Weimin Kong, Zhaoli Ling, Nan Shu, Ying Li, Tong Wu, Mian Zhang, Liang Zhu, Xiaodong Liu, Li Liu
Skeletal muscle accounts for approximately 75% of glucose disposal in body and statins impair glucose metabolism. We aimed to investigate the effect of atorvastatin on glucose metabolism in C2C12 cells. Glucose metabolism and expression of glucose transporter 4 (GLUT4) and hexokinase II (HXKII) were measured following incubation with atorvastatin or pravastatin. Roles of cholesterol in atorvastatin-induced glucose metabolism impairment were investigated via adding cholesterol or mevalonic acid and confirmed by cholesterol depletion with methyl-β-cyclodextrin...
January 12, 2018: Biochemical Pharmacology
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