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https://www.readbyqxmd.com/read/29149618/effectiveness-of-a-patient-centred-empowerment-based-intervention-programme-among-patients-with-poorly-controlled-type-2-diabetes-a-randomised-controlled-trial
#1
Li Cheng, Janet W H Sit, Kai-Chow Choi, Sek-Ying Chair, Xiaomei Li, Yuning Wu, Junhong Long, Meihua Tao
BACKGROUND: Despite extensive efforts and advances in evidence-based diabetes management, poor glycaemic control still remains a challenge in many countries. There is a paucity of research addressing the needs of patients with poorly controlled type 2 diabetes, or exploring the effectiveness of empowerment-based interventions in this vulnerable population. OBJECTIVES: To evaluate the effectiveness of a patient-centred, empowerment-based programme on glycaemic control and self-management behaviours among patients with poorly controlled type 2 diabetes...
November 3, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29149381/substantial-improvement-in-hba1c-following-a-treatment-and-teaching-programme-for-people-with-type-2-diabetes-on-conventional-insulin-therapy-in-an-in-and-outpatient-setting
#2
Nadine Kuniss, Ulrich A Müller, Christof Kloos, Regina Müller, Gerd Starrach, Viktor Jörgens, Guido Kramer
AIMS: The aim of the study was to assess the efficacy of a patient education programme (DTTP) for the optimisation of conventional insulin therapy in patients with type 2 diabetes in an in- and outpatient setting. METHODS: The study was designed as a prospective, longitudinal trial. Thirty-three people with diabetes (females 54.5%, age 61.0 years, diabetes duration 12.7 years, HbA1c 9.3%) from ten general practices in Thuringia (outpatient group) participated in a DTTP for conventional insulin therapy...
November 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29149261/glut10-maintains-the-integrity-of-major-arteries-through-regulation-of-redox-homeostasis-and-mitochondrial-function
#3
Yu-Wei Syu, Hao-Wen Lai, Chung-Lin Jiang, Hong-Yuan Tsai, Chung-Chih Lin, Yi-Ching Lee
Glucose transporter 10 (GLUT10) is a member of the GLUT family of membrane transporters, and mutations in this gene cause arterial tortuosity syndrome (ATS). However, the physiological role and regulation of GLUT10 in arteries remains unclear. To further understand its physiological roles in major arteries, we examined the regulatory mechanisms of GLUT10 in ASMCs and aortic tissues. Interestingly, we find that targeting of GLUT10 to mitochondria is increased in ASMCs under both stress and aging conditions, which enhances dehydroascorbic acid (DHA) uptake and maintains intracellular ascorbic acid (AA) levels...
November 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29149038/adherence-to-hunger-training-over-6-months-and-the-effect-on-weight-and-eating-behaviour-secondary-analysis-of-a-randomised-controlled-trial
#4
Michelle R Jospe, Rachael W Taylor, Josie Athens, Melyssa Roy, Rachel C Brown
Monitoring blood glucose prior to eating can teach individuals to eat only when truly hungry, but how adherence to 'hunger training' influences weight loss and eating behaviour is uncertain. This exploratory, secondary analysis from a larger randomized controlled trial examined five indices of adherence to 'hunger training', chosen a priori, to examine which adherence measure best predicted weight loss over 6 months. We subsequently explored how the best measure of adherence influenced eating behavior in terms of intuitive and emotional eating...
November 17, 2017: Nutrients
https://www.readbyqxmd.com/read/29148978/antidiabetic-and-in-vitro-antioxidant-effects-of-hydromethanol-extract-of-paullinia-pinnata-root-bark-in-alloxan-induced-diabetic-rat
#5
Onoja Samuel Okwudili, Nwachukwu Glory Chimaobi, Ezeja Maxwell Ikechukwu, Omeh Yusuf Ndukaku
Background The study evaluated phytochemical composition, antidiabetic, oral glucose tolerance test and in vitro antioxidant activities of hydromethanol extract of Paullinia pinnata root bark. Methods Cold maceration method was used in extract preparation and scavenging of 2,2-diphenyl-1-picrylhydrazyl radicals was used to evaluate antioxidant properties of the extract. Diabetes was induced with alloxan at the dose of 160 mg/kg. The antidiabetic activity of the extract was tested at doses of 50, 100 and 200 mg/kg, and glibenclamide was used as reference drug...
November 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29148894/metabolic-profile-in-patients-with-mild-obstructive-sleep-apnea
#6
Luciana Oliveira E Silva, Thais M Guimarães, Gabriela P Luz, Glaury Coelho, Luciana Badke, Ildonete R Almeida, Aline Millani-Carneiro, Sergio Tufik, Lia Bittencourt, Sonia M Togeiro
BACKGROUND: Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults. However, it is not clear whether mild OSA has significant metabolic complications. This study examined the prevalence of metabolic syndrome (MS) in patients with mild OSA compared to control group. METHODS: Adults (18-65 years of age) of both genders with a body mass index (BMI) ≤35 kg/m(2) were included. The mild OSA group comprised of patients with an apnea-hypopnea index (AHI) score of ≥5 but ≤15 events/hr of sleep, independent of other symptoms...
November 17, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29147909/the-role-of-the-antioxidant-protein-dj-1-in-type-2-diabetes-mellitus
#7
Daniel Eberhard, Eckhard Lammert
Type 2 diabetes mellitus (T2DM) is a worldwide escalating health disorder resulting from insulin resistance and functional loss of insulin-producing beta cells that finally cause chronically elevated blood glucose concentrations. Here we review the role of ubiquitously expressed antioxidant protein DJ-1 in the pathogenesis of T2DM. In beta cells, DJ-1 protects against oxidative stress, endoplasmic reticulum stress, and streptozotocin- and cytokine-induced stress and preserves beta cell viability and insulin secretion...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29147862/eosinophilia-in-a-peritoneal-dialysis-patient-answers
#8
Shimrit Tzvi-Behr, Yaacov Frishberg, Efrat Ben-Shalom, Choni Rinat, Rachel Becker-Cohen
Icodextrin is a starch-derived glucose polymer used in peritoneal dialysis dialysate to treat volume overload by increasing ultrafiltration in patients with end-stage renal disease. Reported adverse reactions to icodextrin are mild and rare and mainly consist of skin rash that resolves spontaneously after discontinuation of treatment. We describe a young patient with extreme eosinophilia that appeared with the use of icodextrin, disappeared after its discontinuation, and reappeared after a rechallenge with the drug...
November 16, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29147484/berberis-integerrima-ameliorates-insulin-resistance-in-high-fructose-fed-insulin-resistant-rats
#9
Hossein Fallah, Hamed Akbari, Moslem Abolhassani, Abbas Mohammadi, Ahmad Gholamhosseinian
Objectives: This study was aimed to investigate the effect of Berberis integerrima (B. integerrima) extract on insulin sensitivity in high-fructose-fed insulin-resistant rats. Materials and Methods: Experimental rats were randomly divided into two groups: the control group was fed a regular chow diet while other group fed with a high-fructose diet for 8 weeks. After the first six weeks, the animals were treated with B. integerrima extract or pioglitazone for two weeks...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29145714/clinical-and-biochemical-correlates-of-male-hypogonadism-in-type-2-diabetes
#10
A Herrero, M Marcos, P Galindo, J M Miralles, J J Corrales
The origin of hypogonadism, a condition including both symptoms and biochemical criteria of androgen deficiency, in type 2 diabetes is poorly known. In a cross-sectional study of 267 unselected patients, we analyzed the potential correlation of several clinical and biochemical variables as well as chronic micro- and macrovascular diabetic complications with hypogonadism. Hypogonadism was present in 46 patients (17.2%) using a cutoff of total testosterone 10.4 nmol/L and in 31 (11.6%) with a cutoff of 8 nmol/L...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29145418/testosterone-is-protective-against-impaired-glucose-metabolism-in-male-intrauterine-growth-restricted-offspring
#11
Suttira Intapad, John Henry Dasinger, Joel M Fahling, Miles A Backstrom, Barbara T Alexander
Placental insufficiency alters the intrauterine environment leading to increased risk for chronic disease including impaired glucose metabolism in low birth weight infants. Using a rat model of low birth weight, we previously reported that placental insufficiency induces a significant increase in circulating testosterone in male intrauterine growth-restricted offspring (mIUGR) in early adulthood that is lost by 12 months of age. Numerous studies indicate testosterone has a positive effect on glucose metabolism in men...
2017: PloS One
https://www.readbyqxmd.com/read/29145148/honokiol-protects-pancreatic-%C3%AE-cell-against-high-glucose-and-intermittent-hypoxia-induced-injury-by-activating-nrf2-are-pathway-in-vitro-and-in-vivo
#12
Chen-Guang Li, Chang-Lin Ni, Min Yang, Yun-Zhao Tang, Zhu Li, Yan-Juan Zhu, Zhen-Huan Jiang, Bei Sun, Chun-Jun Li
Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with glucose intolerance, insulin resistance and type 2 diabetes mellitus (T2DM). Although several studies have revealed that intermittent hypoxia (IH) in OSAHS may further aggravate pancreatic β cell damage and promote the evolution of type 2 diabetes (T2DM) by increasing oxidative stress, the underlying mechanisms are unclear. Honokiol, a potent radical scavenger, has been demonstrated to ameliorate oxidative stress in many cases. The present study aimed to explore the potential mechanism of IH and diabetes synergistically damage and destruct the pancreatic β cell, examine the effects of honokiol on ameliorating pancreatic β cell injury in this context and explore the mechanism of such effects...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29144890/comprehensive-analysis-of-patients-with-neuromyelitis-optica-spectrum-disorder-nmosd-combined-with-chronic-hepatitis-b-chb-infection-and-seropositive-for-anti-aquaporin-4-antibody
#13
Jia Liu, Li Xu, Zhuo-Lin Chen, Min Li, Huan Yi, Fu-Hua Peng
Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody (AQP4-Ab). Demographic, clinical, laboratory, neuroimaging, outcome, and follow-up data of the 10 patients were retrospectively analyzed...
November 16, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29144814/self-blood-glucose-monitoring-underestimates-hyperglycemia-and-hypoglycemia-as-compared-to-continuous-glucose-monitoring-in-type-1-and-type-2-diabetes
#14
Devna Mangrola, Christine Cox, Arianne S Furman, Sridevi Krishnan, Sidika E Karakas
OBJECTIVE: When glucose records from self-blood glucose monitoring (SBGM) do not reflect estimated average glucose from HgBA1, or when patients' clinical symptoms are not explained by their SBGM records, clinical management of diabetes becomes a challenge. Our objective was to determine the magnitude of differences in glucose values reported by SBGM vs. documented by continuous glucose monitoring (CGM). METHODS: The CGM was conducted by a clinical diabetes educator/registered nurse by the clinic protocol, using the Medtronic iPRO2™ system...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144608/the-relationship-between-urine-ph-and-abnormal-glucose-tolerance-in-a-community-based-study
#15
Sakiko Yoshida, Teruki Miyake, Shin Yamamoto, Shinya Furukawa, Tetsuji Niiya, Hidenori Senba, Sayaka Kanzaki, Osamu Yoshida, Toru Ishihara, Mitsuhito Koizumi, Masashi Hirooka, Teru Kumagi, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa
AIMS/INTRODUCTION: The association between urine pH and abnormal glucose tolerance in men and women is unclear; therefore, we conducted a community-based, cross-sectional study to investigate sex-specific associations between these values, possible indicators of prediabetes, and type 2 diabetes. MATERIALS AND METHODS: We enrolled 4,945 Japanese subjects (2,490 men and 2,455 women), who had undergone annual health checkups. To investigate the relationship between low urine pH and abnormal glucose tolerance, subjects were divided into three groups based on their fasting plasma glucose levels (<6...
November 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29144384/mediator-preference-of-two-different-fad-dependent-glucose-dehydrogenases-employed-in-disposable-enzyme-glucose-sensors
#16
Noya Loew, Wakako Tsugawa, Daichi Nagae, Katsuhiro Kojima, Koji Sode
Most commercially available electrochemical enzyme sensor strips for the measurement of blood glucose use an artificial electron mediator to transfer electrons from the active side of the enzyme to the electrode. One mediator recently gaining attention for commercial sensor strips is hexaammineruthenium(III) chloride. In this study, we investigate and compare the preference of enzyme electrodes with two different FAD-dependent glucose dehydrogenases (FADGDHs) for the mediators hexaammineruthenium(III) chloride, potassium ferricyanide (the most common mediator in commercial sensor strips), and methoxy phenazine methosulfate (mPMS)...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29143895/genetic-approaches-to-the-study-of-gene-variants-and-their-impact-on-the-pathophysiology-of-type-2-diabetes
#17
REVIEW
Monica Szabo, Beáta Máté, Katalin Csép, Theodora Benedek
Diabetes mellitus is an incurable progressive disease, characterized by elevated blood glucose levels, which lead to the development of micro- and macrovascular complications. Although the etiopathology of the disease remains unclear, it seems to be multifactorial, with an important interaction between genetics and environmental causes. Currently, the genetics of type 2 diabetes (T2D) is poorly understood. The recent advance of the genetic technologies and with a better understanding of genetics, more than 120 distinct genetic loci, with more than 150 variants, have been identified that may be involved in the pathogenesis of T2D...
November 16, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29143528/ellagitannins-from-strawberry-with-different-degree-of-polymerization-showed-different-metabolism-through-gastrointestinal-tract-of-rats
#18
Joanna Milala, Monika Kosmala, Elżbieta Karlińska, Jerzy Juskiewicz, Zenon Zdunczyk, Bartosz Fotschki
The present paper describes a comparative study of the metabolism of 1) ellagic acid, 2) monomeric ellagitannins - a mixture of α- and β-bis-hexahydroxydiphenoyl-D-glucose, and 3) dimeric ellagitannins - mainly agrimoniin with both glucose residues being esterified with hexahydroxydiphenoyl (HHDP), in rats fed polyphenol-rich diets. Their metabolites were identified and quantified in selected parts of the gastrointestinal tract i.e., the stomach, small intestine, and cecum on the 2nd, 4th, and 7th day of the experiment, as well as in the feces, blood serum, and urine of rats...
November 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29143147/-esc-guidelines-2017-on-peripheral-arterial-diseases-summary-of-the-most-important-recommendations-and-innovations
#19
C Espinola-Klein
The current European Society of Cardiology (ESC) guidelines on peripheral arterial diseases include recommendations on diagnostics and treatment of atherosclerotic manifestations in peripheral arteries. Because of the high coincidence of atherosclerosis in different arterial territories, screening for other atherosclerotic lesions is necessary in patients with clinical symptoms in one vascular bed. Consistent treatment of cardiovascular risk factors is important in all patients with peripheral atherosclerosis...
November 15, 2017: Herz
https://www.readbyqxmd.com/read/29142578/food-exchange-list-and-dietary-management-of-non-communicable-diseases-in-cultural-perspective
#20
REVIEW
Mahnaz Nasir Khan, Samia Kalsoom, Ayyaz Ali Khan
This review focuses at highlighting the importance of Food Exchange List in cultural perspective, as an effective dietary tool to help individuals' manage their dietary modifications in relation to non communicable diseases whilst specifying measures that can help improve the quality of Food Exchange Lists for combating various non communicable diseases and addressing adherence related issues to specialized diets. A search was done using PubMed & Google Scholar till June 2016. Search terms used were food exchange list AND disease, diet AND non-communicable diseases...
September 2017: Pakistan Journal of Medical Sciences Quarterly
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