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https://www.readbyqxmd.com/read/28634708/speaker-versus-listener-oriented-disfluency-a-re-examination-of-arguments-and-assumptions-from-autism-spectrum-disorder
#1
Paul E Engelhardt, Oliver Alfridijanta, Mhairi E G McMullon, Martin Corley
We re-evaluate conclusions about disfluency production in high-functioning forms of autism spectrum disorder (HFA). Previous studies examined individuals with HFA to address a theoretical question regarding speaker- and listener-oriented disfluencies. Individuals with HFA tend to be self-centric and have poor pragmatic language skills, and should be less likely to produce listener-oriented disfluency. However, previous studies did not account for individual differences variables that affect disfluency. We show that both matched and unmatched controls produce fewer repairs than individuals with HFA...
June 20, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28633567/endogenous-bioelectric-signaling-networks-exploiting-voltage-gradients-for-control-of-growth-and-form
#2
Michael Levin, Giovanni Pezzulo, Joshua M Finkelstein
Living systems exhibit remarkable abilities to self-assemble, regenerate, and remodel complex shapes. How cellular networks construct and repair specific anatomical outcomes is an open question at the heart of the next-generation science of bioengineering. Developmental bioelectricity is an exciting emerging discipline that exploits endogenous bioelectric signaling among many cell types to regulate pattern formation. We provide a brief overview of this field, review recent data in which bioelectricity is used to control patterning in a range of model systems, and describe the molecular tools being used to probe the role of bioelectrics in the dynamic control of complex anatomy...
June 21, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28632539/epidemiologic-analysis-of-elective-operative-procedures-in-infants-less-than-6-months-of-age-in-the-united-states
#3
Lisa M Einhorn, Brian J Young, Jonathan C Routh, Alexander C Allori, Elisabeth T Tracy, Nathaniel H Greene
BACKGROUND: This study uses publicly available data to analyze the total number of elective, potentially deferrable operative procedures involving infants <6 months of age in the United States. We investigated the factors associated with the performance of these procedures in this population. METHODS: The State Ambulatory Surgery Database was used to identify patients in California, North Carolina, New York, and Utah during the years of 2007 to 2010 who were younger than 6 months of age at the time that they underwent outpatient (ambulatory) surgery...
June 16, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28627864/type-ii-endoleaks-when-and-how
#4
Matthew J Grima, Alan Karthikesalingam
Although most type II endoleaks are self-limiting, the most common indication for secondary intervention after endovascular aneurysm repair (EVAR) is type II endoleak. However, it is still debatable when to treat them. Furthermore, different intervention techniques are available to treat type II endoleaks. The aim of this review is to look at current evidence and updates on type II endoleaks after EVAR for abdominal aortic aneurysm and their management.
June 19, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28624680/the-timing-of-spontaneous-detection-and-repair-of-naming-errors-in-aphasia
#5
Julia Schuchard, Erica L Middleton, Myrna F Schwartz
This study examined the timing of spontaneous self-monitoring in the naming responses of people with aphasia. Twelve people with aphasia completed a 615-item naming test twice, in separate sessions. Naming attempts were scored for accuracy and error type, and verbalizations indicating detection were coded as negation (e.g., "no, not that") or repair attempts (i.e., a changed naming attempt). Focusing on phonological and semantic errors, we measured the timing of the errors and of the utterances that provided evidence of detection...
May 25, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28618768/psychosocial-functioning-in-pediatric-patients-with-pectus-excavatum-and-pectus-carinatum
#6
Aliye Tuğba Bahadir, Pınar Kuru Bektaşoğlu, Aylin Çakiroğlu Eser, Ceyda Afacan, Mustafa Yüksel
BACKGROUND/AIM: Pectus excavatum and pectus carinatum are the most commonly seen anterior chest wall deformities. Recent studies reveal that minimal invasive repair of pectus deformities improves the quality of life. Our aim is to assess the psychosocial functioning and sociodemographic characteristics of pediatric patients with pectus deformities and evaluate the differences between patients operated on with minimal invasive repair techniques and nonoperated patients. MATERIALS AND METHODS:  Thirty-two patients with pectus deformities who were operated on 6 months or more before and 31 nonoperated patients participated in the study...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28616296/traumatic-esophageal-perforation-by-a-self-bougienage
#7
Eung-Soo Kim, Jong-Yael Kang, In-Soo Cho, Gwang-Woo Rhee
The case report describes a 75-year-old female with esophageal perforation by a self bougienage. From a decade ago, she had performed an esophageal bougienage by herself with a 70 cm long self-made bougie whenever she suffered from food impaction. On the day of the accident, she went on an outing without carrying the bougie, she pushed a broken bough into her esophagus, eventually the bough perforated her thoracic esophagus. We found some food particles in a large mediastinal abscess cavity, and the perforated esophagus was repaired by interrupted sutures and reinforced with a pedicled intercostal musculopleural flap...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28611002/chondrogenesis-of-human-bone-marrow-mesenchymal-stem-cells-in-3-dimensional-photocrosslinked-hydrogel-constructs-effect-of-cell-seeding-density-and-material-stiffness
#8
Aaron X Sun, Hang Lin, Madalyn R Fritch, He Shen, Pete G Alexander, Michael DeHart, Rocky S Tuan
Three-dimensional hydrogel constructs incorporated with live stem cells that support chondrogenic differentiation and maintenance offer a promising regenerative route towards addressing the limited self-repair capabilities of articular cartilage. In particular, hydrogel scaffolds that augment chondrogenesis and recapitulate the native physical properties of cartilage, such as compressive strength, can potentially be applied in point-of-care procedures. We report here the synthesis of two new materials, [poly-l-lactic acid/polyethylene glycol/poly-l-lactic acid] (PLLA-PEG 1000) and [poly-d,l-lactic acid/polyethylene glycol/poly-d,l-lactic acid] (PDLLA-PEG 1000), that are biodegradable, biocompatible (>80% viability post fabrication), and possess high, physiologically relevant mechanical strength (∼1500 to 1800kPa)...
June 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28609781/a-data-driven-structural-model-of-hssb1-nabp2-obfc2b-self-oligomerization
#9
Christine Touma, Mark N Adams, Nicholas W Ashton, Michael Mizzi, Serene El-Kamand, Derek J Richard, Liza Cubeddu, Roland Gamsjaeger
The maintenance of genome stability depends on the ability of the cell to repair DNA efficiently. Single-stranded DNA binding proteins (SSBs) play an important role in DNA processing events such as replication, recombination and repair. While the role of human single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) in the repair of double-stranded breaks has been well established, we have recently shown that it is also essential for the base excision repair (BER) pathway following oxidative DNA damage. However, unlike in DSB repair, the formation of stable hSSB1 oligomers under oxidizing conditions is an important prerequisite for its proper function in BER...
June 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28608435/cad-cam-fabricated-ceramic-implant-supported-single-crowns-made-from-lithium-disilicate-final-results-of-a-5-year-prospective-cohort-study
#10
Benedikt Christopher Spies, Stefano Pieralli, Kirstin Vach, Ralf-Joachim Kohal
BACKGROUND: All-ceramic bilayer systems suffer from technique-sensitivity, resulting in increased technical complication rates. This might be overcome by monolithic reconstructions, facilitating digital workflows. PURPOSE: To evaluate the clinical and patient-reported outcome of CAD/CAM-fabricated implant-supported single crowns (ISCs) made of lithium disilicate (LS2 ) cemented on ceramic implants 5 years after implant installation. MATERIALS AND METHODS: Twenty-four patients were included in the study...
June 13, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28608149/exercise-capacity-and-self-efficacy-are-associated-with-moderate-to-vigorous-intensity-physical-activity-in-children-with-congenital-heart-disease
#11
Laura Banks, Shelly Rosenthal, Cedric Manlhiot, Chun-Po Steve Fan, Adam McKillop, Patricia E Longmuir, Brian W McCrindle
This study sought to determine whether exercise capacity, self-efficacy, and gross motor skills are associated with moderate-to-vigorous physical activity (MVPA) levels in children, and if these associations differ by congenital heart disease (CHD) type. Medical history was abstracted from chart review. We assessed MVPA levels (via accelerometry), percent-predicted peak oxygen consumption ([Formula: see text] cardiopulmonary exercise test), gross motor skill percentiles (test of gross motor development version-2), and self-efficacy [children's self-perceptions of adequacy and predilection for physical activity scale (CSAPPA scale)]...
June 12, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28606011/delayed-endovascular-stenting-of-right-subclavian-artery-pseudoaneurysm-caused-by-gunshot-accident-in-a-syrian-refugee-a-case-report
#12
Khaled Alawneh, Liqaa Raffee, Shadi Hamouri
Sharp penetrating injuries causing right subclavian artery pseudoaneurysm are considered rare. Surgical repair is reportedly associated with a high mortality rate and is considered technically challenging. (1) In this case report, we report the successful endovascular repair of a delayed pseudoaneurysm of the right subclavian artery caused by a gunshot injury in a 22-year-old Syrian refugee that was associated with significant right brachial panplexopathy. The patient was successfully managed with angioplastic ballooning of the stenotic region of the artery and a covered self-expanding stent...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28604488/anterior-cervical-discectomy-and-fusion-outcomes-over-10-years-a-prospective-study
#13
Glenn R Buttermann
STUDY DESIGN: Prospective cohort study with >10-year follow-up. OBJECTIVE: To assess the long-term, >10-year, clinical outcomes of anterior cervical discectomy and fusion (ACDF) and to compare outcomes based on primary diagnosis of disc herniation; stenosis or advanced degenerative disc disease (DDD); number of levels treated; and preexisting adjacent level degeneration. SUMMARY OF BACKGROUND DATA: ACDF is a proven treatment for patients with stenosis and disc herniation and results in significantly improved short- and intermediate-term outcomes...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28597211/characterization-and-use-of-equine-bone-marrow-mesenchymal-stem-cells-in-equine-cartilage-engineering-study-of-their-hyaline-cartilage-forming-potential-when-cultured-under-hypoxia-within-a-biomaterial-in-the-presence-of-bmp-2-and-tgf-%C3%A3-1
#14
Thomas Branly, Lélia Bertoni, Romain Contentin, Rodolphe Rakic, Tangni Gomez-Leduc, Mélanie Desancé, Magalie Hervieu, Florence Legendre, Sandrine Jacquet, Fabrice Audigié, Jean-Marie Denoix, Magali Demoor, Philippe Galéra
Articular cartilage presents a poor capacity for self-repair. Its structure-function are frequently disrupted or damaged upon physical trauma or osteoarthritis in humans. Similar musculoskeletal disorders also affect horses and are the leading cause of poor performance or early retirement of sport- and racehorses. To develop a therapeutic solution for horses, we tested the autologous chondrocyte implantation technique developed on human bone marrow (BM) mesenchymal stem cells (MSCs) on horse BM-MSCs. This technique involves BM-MSC chondrogenesis using a combinatory approach based on the association of 3D-culture in collagen sponges, under hypoxia in the presence of chondrogenic factors (BMP-2 + TGF-β1) and siRNA to knockdown collagen I and HtrA1...
June 9, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28596334/self-repairing-cells-how-single-cells-heal-membrane-ruptures-and-restore-lost-structures
#15
REVIEW
Sindy K Y Tang, Wallace F Marshall
Many organisms and tissues display the ability to heal and regenerate as needed for normal physiology and as a result of pathogenesis. However, these repair activities can also be observed at the single-cell level. The physical and molecular mechanisms by which a cell can heal membrane ruptures and rebuild damaged or missing cellular structures remain poorly understood. This Review presents current understanding in wound healing and regeneration as two distinct aspects of cellular self-repair by examining a few model organisms that have displayed robust repair capacity, including Xenopus oocytes, Chlamydomonas, and Stentor coeruleus Although many open questions remain, elucidating how cells repair themselves is important for our mechanistic understanding of cell biology...
June 9, 2017: Science
https://www.readbyqxmd.com/read/28594747/groin-pain-characteristics-and-recurrence-rates-three-year-results-of-a-randomized-controlled-trial-comparing-self-gripping-progrip-mesh-and-sutured-polypropylene-mesh-for-open-inguinal-hernia-repair
#16
Willem A R Zwaans, Tim Verhagen, Luuk Wouters, Maarten J A Loos, Rudi M H Roumen, Marc R M Scheltinga
OBJECTIVE: The aim of this study was to investigate long-term groin pain and inguinal hernia recurrence rates of 2 types of mesh and to describe the evolution of postoperative groin sensory disturbances. SUMMARY OF BACKGROUND DATA: Some patients with an inguinal hernia develop chronic pain following open mesh insertion. Previous trials comparing a semi-resorbable, self-gripping Progrip mesh with a standard sutured polypropylene mesh found conflicting results regarding recurrence rates and residual groin pain...
June 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28592117/mechanisms-regulating-radiosensitivity-of-glioma-stem-cells
#17
Y Liu, Y Shen, T Sun, W Yang
Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/β-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28590066/the-roles-of-signaling-pathways-in-bone-repair-and-regeneration
#18
REVIEW
Maryam Majidinia, Bahman Yousefi
Regenerative medicine has sparked interest in potential strategies for bone repair. Bone defects are widespread and could be caused by trauma, congenital malformations, infections, and surgery. Although bone has a large self-healing capacity, some defects or fractures are too big to regenerate. To regenerate bone structures which can be used for treatment of patients, bone growth must be induced by a number of bioactive implantable materials, cell types and intracellular and extracellular molecular signaling pathways...
June 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28579877/the-application-of-graphene-oxidized-combining-with-decellularized-scaffold-to-repair-of-sciatic-nerve-injury-in-rats
#19
Qiaoling Wang, Jinlong Chen, Qingfei Niu, Xiumei Fu, Xiaohong Sun, Xiaojie Tong
This paper combined the decellularized scaffold of sciatic nerve of rats with graphene oxidized (GO), studied and facilitated the regeneration of sciatic nerve of rats, and provided the basis for the clinical application of nanomaterials. GO was prepared through improving Hammer's Method. Fourier Infrared Spectrum was used to scan and detect the functional groups in GO of sample by using the pellet method, the microcosmic morphological appearance of GO was observed by using the scanning electron microscope...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28577176/complement-c5a-induces-mesenchymal-stem-cell-apoptosis-during-the-progression-of-chronic-diabetic-complications
#20
Ming Zhu, Xiao He, Xiao-Hui Wang, Wei Qiu, Wei Xing, Wei Guo, Tian-Chen An, Luo-Quan Ao, Xue-Ting Hu, Zhan Li, Xiao-Ping Liu, Nan Xiao, Jian Yu, Hong Huang, Xiang Xu
AIMS/HYPOTHESIS: Regeneration and repair mediated by mesenchymal stem cells (MSCs) are key self-protection mechanisms against diabetic complications, a reflection of diabetes-related cell/tissue damage and dysfunction. MSC abnormalities have been reported during the progression of diabetic complications, but little is known about whether a deficiency in these cells plays a role in the pathogenesis of this disease. In addition to MSC resident sites, peripheral circulation is a major source of MSCs that participate in the regeneration and repair of damaged tissue...
June 3, 2017: Diabetologia
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