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https://www.readbyqxmd.com/read/29155940/stented-balloon-fenestration-before-entry-repair-using-the-frozen-elephant-trunk-technique-for-chronic-aortic-dissection
#1
Naomichi Uchida, Yoshitaka Yamane, Tomokuni Furukawa
Endovascular fenestration on the abdominal aorta is effective for preventing visceral malperfusion in aortic dissection. We report a case of stented balloon fenestration before residual entry repair using the frozen elephant trunk technique for chronic aneurysmal dissection after ascending aortic replacement for DeBakey I aortic dissection. We recognized poor communication between the true lumen and false lumen in the abdominal aorta, and visceral perfusion depended almost entirely on the proximal large entry...
October 9, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29153820/aortic-arch-hybrid-repair-stent-bridging-of-the-supra-aortic-vessel-anastomoses-savsteb
#2
Maximilian Pichlmaier, Maximilian Luehr, Simon Rutkowski, Thomas Fabry, Sabina Guenther, Christian Hagl, Sven Peterss
The reattachment of the supra-aortic vessels during hybrid arch repair using a branched prosthesis is time consuming and sometimes technically challenging. Here, we describe the surgical technique of bridging the end-to-end anastomoses between the graft branches and the supra-aortic vessels by self-expanding covered stents to reduce suturing time, avoid anastomotic bleeding, enhance true lumen remodeling, and improve vessel alignment to the hybrid graft.
December 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29148804/a-nanobionic-light-emitting-plant
#3
Seon-Yeong Kwak, Juan Pablo Giraldo, Min Hao Wong, Volodymyr Koman, Tedrick Lew, Jon Ell, Mark Weidman, Rosalie Sinclair, Markita P Landry, William A Tisdale, Michael S Strano
The engineering of living plants for visible light emission and sustainable illumination is compelling because plants possess independent energy generation and storage mechanisms and autonomous self-repair. Herein, we demonstrate a plant nanobionic approach that enables exceptional luminosity and lifetime utilizing four chemically-interacting nanoparticles, including firefly luciferase conjugated silica (SNP-Luc), D-luciferin releasing poly(lactic-co-glycolic acid) (PLGA-LH2), coenzyme A functionalized chitosan (CS-CoA) and semiconductor nanocrystal phosphors for longer wavelength modulation...
November 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/29137495/development-of-chondrocyte-seeded-electrosprayed-nanoparticles-for-repair-of-articular-cartilage-defects-in-rabbits
#4
Shan-Wei Yang, Kai-Chi Ku, Shu-Ying Chen, Shyh-Ming Kuo, I-Fen Chen, Ting-Yi Wang, Shwu-Jen Chang
Due to limited self-healing capacity in cartilages, there is a rising demand for an innovative therapy that promotes chondrocyte proliferation while maintaining its biofunctionality for transplantation. Chondrocyte transplantation has received notable attention; however, the tendencies of cell de-differentiation and de-activation of biofunctionality have been major hurdles in its development, delaying this therapy from reaching the clinic. We believe it is due to the non-stimulative environment in the injured cartilage, which is unable to provide sustainable physical and biological supports to the newly grafted chondrocytes...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29133075/spinal-cord-self-repair-during-tail-regeneration-in-polypedates-maculatus-and-putative-role-of-fgf1-as-a-neurotrophic-factor
#5
Jutshina Hota, Sushri Sangita Pati, Pravati Kumari Mahapatra
Spinal cord injury could be fatal in man and often results in irreversible medical conditions affecting mobility. However, anuran amphibians win over such pathological condition by the virtue of regeneration abilities. The tail of anuran tadpoles therefore allures researchers to study spinal cord injury and self- repair process. In the present study, we inflicted injury to the spinal cord by means of surgical transection of the tail and investigated the self-repair activity in the tadpoles of the Indian tree frog Polypedates maculatus...
November 10, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29131415/superior-toughness-and-fast-self-healing-at-room-temperature-engineered-by-transparent-elastomers
#6
Seon-Mi Kim, Hyeonyeol Jeon, Sung-Ho Shin, Seul-A Park, Jonggeon Jegal, Sung Yeon Hwang, Dongyeop X Oh, Jeyoung Park
The most important properties of self-healing polymers are efficient recovery at room temperature and prolonged durability. However, these two characteristics are contradictory, making it difficult to optimize them simultaneously. Herein, a transparent and easily processable thermoplastic polyurethane (TPU) with the highest reported tensile strength and toughness (6.8 MPa and 26.9 MJ m(-3) , respectively) is prepared. This TPU is superior to reported contemporary room-temperature self-healable materials and conveniently heals within 2 h through facile aromatic disulfide metathesis engineered by hard segment embedded aromatic disulfides...
November 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29126604/zonal-variation-of-mri-measurable-parameters-classifies-cartilage-degradation
#7
Allison K M Fleck, Uwe Kruger, Kyrsten Carlson, Caitlin Waltz, Scott A McCallum, X Lucas Lu, Leo Q Wan
Osteoarthritis (OA) is a degenerative joint disease resulting in the deterioration of articular cartilage, a tissue with minimal ability to self-repair. Early diagnosis of OA with non-invasive imaging techniques such as magnetic resonance imaging (MRI) could provide an opportunity to intervene and slow or reverse this degeneration process. This study examines the classification of degradation states using MRI measurements. Enzymatic degradation was used to specifically target proteoglycans alone, collagen alone and both cartilage components sequentially...
October 24, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29126412/obstetric-fistulae-in-southern-mozambique-incidence-obstetric-characteristics-and-treatment
#8
Sibone Mocumbi, Claudia Hanson, Ulf Högberg, Helena Boene, Peter von Dadelszen, Anna Bergström, Khátia Munguambe, Esperança Sevene
BACKGROUND: Obstetric fistula is one of the most devastating consequences of unmet needs in obstetric services. Systematic reviews suggest that the pooled incidence of fistulae in community-based studies is 0.09 per 1000 recently pregnant women; however, as facility delivery is increasing, for the most part, in Africa, incidence of fistula should decrease. Few population-based studies on fistulae have been undertaken in Sub-Saharan Africa, including Mozambique. This study aimed to estimate the incidence of obstetric fistulae in recently delivered mothers, and to describe the clinical characteristics and care, as well as the outcome, after surgical repair...
November 10, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29126040/5-year-results-of-the-1-5cm-incision-achilles-tendon-repair
#9
Samuel K K Ling, Amanda Slocum, T H Lui
BACKGROUND: To study a hypothesis that the cost-effective 1.5cm medial incision Achilles tendon repair technique will provide good functional outcomes which are maintained for over 5 years. METHOD: Prospective study of 12 consecutive cases with a minimal 5-year follow-up were recruited from April 2008 to November 2010. Cases whom were mentally incompetent or those which required concomitant procedures were excluded. Outcomes measures included the numeric pain rating scale, motor power strength, range of motion, functional scoring using the AOFAS hindfoot score and patient's self-assessment using the Foot and Ankle Outcome Score (FAOS)...
June 16, 2017: Foot
https://www.readbyqxmd.com/read/29123550/mesenchymal-stem-cells-for-cartilage-regeneration-of-tmj-osteoarthritis
#10
REVIEW
Dixin Cui, Hongyu Li, Xin Xu, Ling Ye, Xuedong Zhou, Liwei Zheng, Yachuan Zhou
Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29117575/self-assembling-peptide-hydrogel-enables-instant-epicardial-coating-of-the-heart-with-mesenchymal-stromal-cells-for-the-treatment-of-heart-failure
#11
Yuki Ichihara, Masahiro Kaneko, Kenichi Yamahara, Marinos Koulouroudias, Nobuhiko Sato, Rakesh Uppal, Kenji Yamazaki, Satoshi Saito, Ken Suzuki
Transplantation of mesenchymal stromal cells (MSCs) is an emerging therapy for the treatment of heart failure. However, the delivery method of MSC is currently suboptimal. The use of self-assembling peptide hydrogels, including PuraMatrix(®) (PM; 3-D Matrix, Ltd), has been reported for clinical hemostasis and in research models. This study demonstrates the feasibility and efficacy of an advanced approach for MSC-therapy, that is coating of the epicardium with the instantly-produced PM hydrogel incorporating MSCs (epicardial PM-MSC therapy)...
October 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/29117409/development-of-a-perfusion-based-cadaveric-simulation-model-integrated-into-neurosurgical-training-feasibility-based-on-reconstitution-of-vascular-and-cerebrospinal-fluid-systems
#12
Gabriel Zada, Joshua Bakhsheshian, Martin Pham, Mike Minneti, Eisha Christian, Jesse Winer, Aaron Robison, Bozena Wrobel, Jonathan Russin, William J Mack, Steven Giannotta
BACKGROUND: Novel methodologies providing realistic simulation of the neurosurgical operating room environment are currently needed, particularly for highly subspecialized operations with steep learning curves, high-risk profiles, and demands for advanced psychomotor skills. OBJECTIVE: To describe the development of a curriculum for using perfusion-based cadaveric simulation models in a "Mock Operating Room" for neurosurgical procedures. METHODS: At the USC Keck School of Medicine Fresh Tissue Dissection Laboratory between 2012 and 2016, 43 cadaveric specimens underwent cannulation of the femoral or carotid artery and artificial perfusion of the arterial system, and/or cannulation of the intradural cervical spine for intrathecal reconstitution of the cerebrospinal fluid (CSF) system...
May 13, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29114686/modulation-of-xpc-peptide-on-binding-tb-3-to-euplotes-octocarinatus-centrin
#13
Enxian Shi, Wenlong Zhang, Yaqin Zhao, Binsheng Yang
Centrins are Ca(2+)-binding proteins found throughout eukaryotic organisms. Xeroderma pigmentosum group C protein (XPC), a dominant component of the nuclear excision repair (NER) pathway, is a critical target protein of centrins. A 22-residue peptide (K842-R863) from XPC was used to investigate the effect of metal ions (Ca(2+) and Tb(3+)) on the peptide binding of Euplotes octocarinatus centrin (EoCen) by isothermal titration calorimetry (ITC) and fluorescence spectroscopy. ITC and tryptophan spectrofluorimetric titrations revealed that metal ions (Ca(2+) and Tb(3+)) could enhance the affinity between EoCen and the XPC peptide, and the enhanced effects were closely related to the ion potential of metal ions...
November 8, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29114427/adhesive-system-affects-repair-bond-strength-of-resin-composite
#14
Ozgur Irmak, Ozge Celiksoz, Begum Yilmaz, Batu Can Yaman
Purpose: This study evaluated the effects of different adhesive systems on repair bond strength of aged resin composites. Materials and Methods: Ninety composite discs were built and half of them were subjected to thermal aging. Aged and non-aged specimens were repaired with resin composite using three different adhesive systems; a two-step self-etch adhesive, a two-step total-etch adhesive and a one-step self-etch adhesive; then they were subjected to shear forces...
2017: J Istanb Univ Fac Dent
https://www.readbyqxmd.com/read/29113471/oxidative-stress-in-stem-cell-aging
#15
Feng Chen, Yingxia Liu, Nai-Kei Wong, Jia Xiao, Kwok-Fai So
Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell aging. Excessive production of reactive oxygen species and insufficient cellular antioxidant reserves compromise cell repair and metabolic homeostasis, which serves as a mechanistic switch for a variety of aging-related pathways...
September 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29110946/assessment-of-the-electronic-retinal-implant-alpha-ams-in-restoring-vision-to-blind-patients-with-end-stage-retinitis-pigmentosa
#16
Thomas L Edwards, Charles L Cottriall, Kanmin Xue, Matthew P Simunovic, James D Ramsden, Eberhart Zrenner, Robert E MacLaren
PURPOSE: To report the initial efficacy results of the Retina Implant Alpha AMS (Retina Implant AG, Reutlingen, Germany) for partial restoration of vision in end-stage retinitis pigmentosa (RP). DESIGN: Prospective, single-arm, investigator-sponsored interventional clinical trial. Within-participant control comprising residual vision with the retinal implant switched ON versus OFF in the implanted eye. PARTICIPANTS: The Retina Implant Alpha AMS was implanted into the worse-seeing eye of 6 participants with end-stage RP and no useful perception of light vision...
October 27, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29107132/staged-urethroplasty-for-penile-urethral-strictures-from-lichen-sclerosus-and-failed-hypospadias-repair
#17
Bradley D Figler, Andrew Gomella, Logan Hubbard
OBJECTIVE: To present our technique for staged urethroplasty with buccal mucosa graft. METHODS: The patient presented is a 42 year-old male with a history of congenital hypospadias repaired as a child. He developed a penile urethral stricture at age 30 and was managed with self intermittent dilation. Recently, dilation became more difficult, and he was referred for reconstruction. Work-up revealed a high-grade stricture extending from the meatus to the site of the previous anastomosis at the penoscrotal junction...
October 26, 2017: Urology
https://www.readbyqxmd.com/read/29105001/design-of-projectrun21-a-14-week-prospective-cohort-study-of-the-influence-of-running-experience-and-running-pace-on-running-related-injury-in-half-marathoners
#18
Camma Damsted, Erik Thorlund Parner, Henrik Sørensen, Laurent Malisoux, Rasmus Oestergaard Nielsen
BACKGROUND: Participation in half-marathon has been steeply increasing during the past decade. In line, a vast number of half-marathon running schedules has surfaced. Unfortunately, the injury incidence proportion for half-marathoners has been found to exceed 30% during 1-year follow-up. The majority of running-related injuries are suggested to develop as overuse injuries, which leads to injury if the cumulative training load over one or more training sessions exceeds the runners' load capacity for adaptive tissue repair...
November 6, 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/29103173/a-role-for-the-mutagenic-dna-self-catalyzed-depurination-mechanism-in-the-evolution-of-7sl-derived-rnas
#19
Maxwell P Gold, Jacques R Fresco
The Alu element, the most prevalent SINE (short interspersed element) in the human genome, is one of the many RNA-encoding genes that evolved from the 7SL RNA gene. During analysis of the evolution of 7SL-derived RNAs, two distinct evolutionary intermediates capable of self-catalyzed DNA depurination (SDP) were identified. These SDP sequences spontaneously create apurinic sites that can result in increased mutagenesis due to their error-prone repair. This DNA self-depurination mechanism has been shown both in vitro and in vivo to lead to substitution and short frameshift mutations at a frequency that far exceeds their occurrence due to random errors in DNA replication...
October 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29100774/bilateral-hip-arthroscopy-direct-comparison-of-primary-acetabular-labral-repair-and-primary-acetabular-labral-reconstruction
#20
Brian J White, Julie Patterson, Mackenzie M Herzog
PURPOSE: Directly compare primary acetabular labral repair versus primary acetabular labral reconstruction using a self-controlled cohort study design. METHODS: Patients who underwent primary labral repair in one hip and primary labral reconstruction using iliotibial band allograft in the other hip by a single surgeon between August 2009 and November 2014 were identified. One patient with inflammatory arthritis was excluded. Patient-reported outcome data included change in Modified Harris Hip Score (MHHS), Lower Extremity Functional Scale (LEFS), average pain using a 10-point visual analog scale (VAS), and patient satisfaction (1: very dissatisfied, 10: very satisfied)...
October 31, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
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