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https://www.readbyqxmd.com/read/29779212/periodontal-regeneration-via-chemo-attractive-constructs
#1
Xinjie Cai, Fang Yang, X Frank Walboomers, Yining Wang, John A Jansen, Jeroen J J P van den Beucken, Adelina S Plachokova
AIM: Chemo-attractants, such as stromal cell-derived factor-1α (SDF-1α), can offer an advantage for periodontal regeneration by recruiting the patient's own stem cells to stimulate self-repair. We here developed a chemo-attractive construct for periodontal regeneration using SDF-1α and evaluated its efficacy in vivo. MATERIALS AND METHODS: SDF-1α was loaded on gelatin sponge and tested in vitro for SDF-1α release. Subsequently, SDF-1α constructs were implanted into rat periodontal defects for 1 and 6 weeks, with unloaded materials and empty defects as controls...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29778801/injury-and-stress-responses-of-adult-neural-crest-derived-cells
#2
REVIEW
Vadims Parfejevs, Ana T Antunes, Lukas Sommer
Multipotent neural crest cells can self-renew and give rise to a plethora of neural and non-neural cell types in the vertebrate embryo. Intriguingly, cells reminiscent of such neural crest stem cells (NCSCs) have also been isolated from various postnatal and adult neural crest (NC)-derived structures. However, it has been debated whether NCSC-like cells in the adult correspond to 'in vitro artefacts' emerging upon isolation or fulfil a physiological role in vivo. Here, we discuss recent findings indicating that in different adult NC derivatives, injury or stress responses induce a NCSC-like state, presumably by reprogramming of differentiated cells such as Schwann cells...
May 17, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29775462/analytical-scaling-relations-to-evaluate-leakage-and-intrusion-in-intermittent-water-supply-systems
#3
David D J Taylor, Alexander H Slocum, Andrew J Whittle
Intermittent water supplies (IWS) deliver piped water to one billion people; this water is often microbially contaminated. Contaminants that accumulate while IWS are depressurized are flushed into customers' homes when these systems become pressurized. In addition, during the steady-state phase of IWS, contaminants from higher-pressure sources (e.g., sewers) may continue to intrude where pipe pressure is low. To guide the operation and improvement of IWS, this paper proposes an analytic model relating supply pressure, supply duration, leakage, and the volume of intruded, potentially-contaminated, fluids present during flushing and steady-state...
2018: PloS One
https://www.readbyqxmd.com/read/29774991/aggregate-mesenchymal-stem-cell-delivery-ameliorates-the-regenerative-niche-for-muscle-repair
#4
Marissa A Ruehle, Hazel Y Stevens, Aaron M Beedle, Robert E Guldberg, Jarrod A Call
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease due to the absence of the dystrophin protein from the muscle cell membrane which renders the muscle susceptible to continuous damage. In DMD patients, muscle weakness, together with cycles of degeneration/regeneration and replacement with non-contractile tissue, limit mobility and lifespan. Since the loss of dystrophin result in loss of polarity and a reduction in the number of self-renewing satellite cells, it is postulated that these patients could achieve an improved quality of life if delivered cells could restore satellite cell function...
May 18, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29774645/a-novel-rapidly-self-healing-host-guest-supramolecular-hydrogel-with-high-mechanical-strength-and-excellent-biocompatibility
#5
Zhifang Wang, Yipeng Ren, Ye Zhu, Lijing Hao, Yunhua Chen, Geng An, Hongkai Wu, Xuetao Shi, Chuanbin Mao
It is still a challenge to achieve both excellent mechanical strength and biocompatibility in hydrogels. Here we exploited two interactions to form a novel biocompatible, slicing-resistant and self-healing hydrogel. One is the molecular host-guest recognition between a host (isocyanatoethyl acrylate-modified β-cyclodextrin, β-CD-AOI2) and a guest (2-(2-(2-(2-(Adamantyl-1-oxy)ethoxy)ethoxy) ethoxy)ethanol acrylate, A-TEG-Ad) to form novel "three-arm" host-guest supramolecules (HGSMs). Another is the covalent bonding between HGSMs (achieved by UV-initiated polymerization) to form a strong network in the hydrogel...
May 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29774499/factors-influencing-l2-self-repair-behavior-the-role-of-l2-proficiency-attentional-control-and-l1-self-repair-behavior
#6
Michael Zuniga, Daphnée Simard
Self-repairs, that is revisions of speech that speakers themselves initiate and complete (Salonen and Laakso in J Child Lang 36:859, 2009. https://doi.org/10.1017/s0305000908009240 ), are frequently used to observe the cognitive and linguistic processes underlying second language (L2) speech production. Previous research has shown that factors such as L2 proficiency, attentional control and native language (L1) self-repair behavior interact with L2 self-repair behavior. To our knowledge, however, no research has examined how these three factors interact within a cohort of L2 speakers...
May 17, 2018: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/29772932/recent-advances-in-kartogenin-for-cartilage-regeneration
#7
Gaorui Cai, Wei Liu, Yong He, Jianghong Huang, Li Duan, Jianyi Xiong, Lijun Liu, Daping Wang
Either osteoarthritisor sports-related injuries can lead to cartilage defects,whereas both chondrocyte self-renewal and conventional treatments face limitations. In cartilage regenerative medicine, growth factors are commonly used to induce chondrogenic differentiation of stem cells. However, application of growth factors is confined by some drawbacks. Emerging small molecules are regarded as an alternative for cartilage regeneration. A recently discovered small-molecule compound, kartogenin (KGN), has been proven to be a chondrogenic and chondroprotective agent and is more effective in inducing cartilage regeneration when compared with growth factors...
May 18, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29770571/using-poly-l-lactic-acid-and-poly-%C3%A9-caprolactone-blends-to-fabricate-self-expanding-watertight-and-biodegradable-surgical-patches-for-potential-fetoscopic-myelomeningocele-repair
#8
Rigwed Tatu, Marc Oria, Sarah Pulliam, Lorenzo Signey, Marepalli B Rao, Jose L Peiro, Chia-Ying Lin
Our study focuses on the development and characterization of a self-expanding, watertight and biodegradable patch for fetoscopic myelomeningocele (MMC) prenatal repair. We fabricated poly(l-lactic acid) (PLA) and poly(ɛ-caprolactone) (PCL) blend films by solution casting. Formulation c with average glass transition temperature of 37.6 ± 1.2°C was chosen for temporospatial recovery. Favorable results from surface studies reflected homogeneous dispersion of polymers in the blend. The cytotoxicity was studied in human foreskin fibroblasts...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29767289/regenerative-medicine-applications-of-mesenchymal-stem-cells
#9
Samaneh Hosseini, Leila Taghiyar, Fatemeh Safari, Mohamadreza Baghaban Eslaminejad
A major research challenge is to develop therapeutics that assist with healing damaged tissues and organs because the human body has limited ability to restore the majority of these tissues and organs to their original state. Tissue engineering (TE) and regenerative medicine (RM) promises to offer efficient therapeutic biological strategies that use mesenchymal stem cells (MSCs). MSCs possess the capability for self-renewal, multilineage differentiation, and immunomodulatory properties that make them attractive for clinical applications...
May 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29765416/combating-osteoarthritis-through-stem-cell-therapies-by-rejuvenating-cartilage-a-review
#10
REVIEW
Navneet Kumar Dubey, Viraj Krishna Mishra, Rajni Dubey, Shabbir Syed-Abdul, Joseph R Wang, Peter D Wang, Win-Ping Deng
Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29762533/self-healing-capacity-of-asphalt-mixtures-including-by-products-both-as-aggregates-and-heating-inductors
#11
Marta Vila-Cortavitarte, Daniel Jato-Espino, Daniel Castro-Fresno, Miguel Á Calzada-Pérez
Major advances have been achieved in the field of self-healing by magnetic induction in which the addition of metallic particles into asphalt mixtures enables repairing their own cracks. This technology has already been proven to increase the life expectancy of roads. Nevertheless, its higher costs in comparison with conventional maintenance caused by the price of virgin metallic particles still makes it unattractive for investment. This research aimed at making this process economically accessible as well as environmentally efficient...
May 15, 2018: Materials
https://www.readbyqxmd.com/read/29761344/beyond-the-magic-bullet-current-progress-of-therapeutic-vaccination-in-multiple-sclerosis
#12
Barbara Willekens, Nathalie Cools
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS) characterized by neuroinflammation, neurodegeneration and impaired repair mechanisms that lead to neurological disability. The crux of MS is the patient's own immune cells attacking self-antigens in the CNS, namely the myelin sheath that protects nerve cells of the brain and spinal cord. Restoring antigen-specific tolerance via therapeutic vaccination is an innovative and exciting approach in MS therapy. Indeed, leveraging the body's attempt to prevent autoimmunity, i...
May 14, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29758244/neural-stem-cell-therapies-and-hypoxic-ischemic-brain-injury
#13
REVIEW
Lei Huang, Lubo Zhang
Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic effects of neural stem cell-based treatments for hypoxic-ischemic brain injury. There are two major strategies of neural stem cell-based therapies: transplanting exogenous neural stem cells and boosting self-repair of endogenous neural stem cells. Neural stem cell transplantation has been proved to improve functional recovery after brain injury through multiple by-stander mechanisms (e...
May 11, 2018: Progress in Neurobiology
https://www.readbyqxmd.com/read/29757746/biomedical-materials-learn-to-heal-themselves-self-healing-polymers-hydrogels-and-artificial-muscles-are-mimicking-nature-s-repair-mechanisms
#14
David L Chandler
Maintaining sterility in emergency and operating rooms can be challenging, especially in cases of highly infectious disease outbreaks or toxic spills. A simple nick in a surgical glove under such circumstances could have deadly consequences. But, now, a variety of promising new materials in development may lead to everything from self-healing gloves and bandages to bone, blood vessel, and muscle scaffolding implants that could repair themselves the way tissues do. In some cases, repair might be triggered by an external stimulus, such as heat; in other cases, these materials would naturally heal by themselves over time...
May 2018: IEEE Pulse
https://www.readbyqxmd.com/read/29755090/-successful-surgical-repair-of-the-aortic-annular-infective-endocarditis-with-subvalvular-abscess-report-of-a-case
#15
Manabu Shiraishi, Daigo Shinoda, Nobu Yokoyama, Satoshi Itoh
A 49-year-old female was admitted to our hospital with a history of fever for 2 weeks and consciousness disorder.Transthoracic echocardiography demonstrated aortic regurgitation with a mobile fibrous band adhering to the right cusp. Infective endocarditis was diagnosed by positive blood culture and echocardiographic findings. Emergent aortic valve surgery was performed because of uncontrollable infection. A destroyed aortic annulus and subvalvular abscess was found during the operation. Removal of abscess tissue and annuloplasty with self-pericardium were successfully performed...
May 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29751657/ureolytic-non-ureolytic-bacteria-co-cultured-self-healing-agent-for-cementitious-materials-crack-repair
#16
Hyeong Min Son, Ha Yeon Kim, Sol Moi Park, Haeng Ki Lee
The present study investigated the CaCO₃ precipitation performance of ureolytic and non-ureolytic bacteria co-cultured as a self-healing agent for cementitious materials crack repair. Three different inoculum ratios of ureolytic Sporosarcina pasteurii and non-ureolytic Bacillus thuringiensis (10:0, 8:2, or 5:5) were used. The effect of coculturing ureolytic and non-ureolytic bacteria on microbial metabolism was investigated by measuring the rate of growth in urea-containing medium and the rate of NH₄⁺ and CaCO₃ production in urea⁻calcium lactate medium...
May 11, 2018: Materials
https://www.readbyqxmd.com/read/29751029/accelerated-wound-healing-by-injectable-star-poly-ethylene-b-poly-propylene-sulfide-scaffolds-loaded-with-poorly-water-soluble-drugs
#17
Suwei Zhu, Shuoran Li, Helena Escuin-Ordinas, Robert Dimatteo, Wexian Xi, Antoni Ribas, Tatiana Segura
Injectable hydrogel matrices take the shape of a wound cavity and serve as scaffold for tissue repair and regeneration. Yet these materials are generally hydrophilic, limiting the incorporation of poorly water soluble, hydrophobic drugs. Here we show this shortcoming is circumvented through a star-shaped amphiphilic block copolymer comprising poly(ethylene glycol) and poly (propylene sulfide). This star-shaped amphiphilic polymer self-assembles in an aqueous medium into a physically stable hydrogel and effectively dissolves hydrophobic molecules delivering them at therapeutic doses...
May 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29749042/miscommunication-in-doctor-patient-communication
#18
Rose McCabe, Patrick G T Healey
The effectiveness of medical treatment depends on the quality of the patient-clinician relationship. It has been proposed that this depends on the extent to which the patient and clinician build a shared understanding of illness and treatment. Here, we use the tools of conversation analysis (CA) to explore this idea in the context of psychiatric consultations. The CA "repair" framework provides an analysis of the processes people use to deal with problems in speaking, hearing, and understanding. These problems are especially critical in the treatment of psychosis where patients and health care professionals need to communicate about the disputed meaning of hallucinations and delusion...
April 2018: Topics in Cognitive Science
https://www.readbyqxmd.com/read/29746554/effects-of-collagen-matrix-and-bioreactor-cultivation-on-cartilage-regeneration-of-a-full-thickness-critical-size-knee-joint-cartilage-defects-with-subchondral-bone-damage-in-a-rabbit-model
#19
Kuo-Hwa Wang, Richard Wan, Li-Hsuan Chiu, Yu-Hui Tsai, Chia-Lang Fang, John F Bowley, Kuan-Chou Chen, Hsin-Nung Shih, Wen-Fu Thomas Lai
Cartilage has limited self-repair ability. The purpose of this study was to investigate the effects of different species of collagen-engineered neocartilage for the treatment of critical-size defects in the articular joint in a rabbit model. Type II and I collagen obtained from rabbits and rats was mixed to form a scaffold. The type II/I collagen scaffold was then mixed with rabbit chondrocytes to biofabricate neocartilage constructs using a rotating cell culture system [three-dimensional (3D)-bioreactor]. The rabbit chondrocytes were mixed with rabbit collagen scaffold and rat collagen scaffold to form neoRBT (neo-rabbit cartilage) and neoRAT (neo-rat cartilage) constructs, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29745504/-self-assembling-peptide-gfs-4-nanofiber-scaffolds-for-three-dimensional-cell-cultures-and-myocardial-infarction-repair
#20
Zhenyin Chen, Yuanyuan Yue, Huinan Zhang, Chunyan Chen, Bo Liu, Xueqin Li, Jing Wen, Shuyi Wu, Zhongli Luo
The purpose of this study is to investigate the effects of self-assembling peptide GFS-4 on three-dimen-sional myocardial cell culture and tissue repair of myocardial infarction. The circular dichroism (CD) spectrum was used to detect secondary structure of GFS-4, and atomic force microscope (AFM) was used to analyze the microstructure of self-assembly. The nanofiber scaffolds self-assembled by GFS-4 were used as the three-dimensional culture material to observe the growth effect of cardiomyocytes. The model of myocardial infarction was established and the effect of GFS-4 on myocardial infarction was studied...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
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