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Richard Odongo Magwanga, Pu Lu, Joy Nyangasi Kirungu, Qi Dong, Yangguang Hu, Zhongli Zhou, Xiaoyan Cai, Xingxing Wang, Yuqing Hou, Kunbo Wang, Fang Liu
Late embryogenesis abundant (LEA) proteins play key roles in plant drought tolerance. In this study, 157, 85 and 89 candidate LEA2 proteins were identified in G. hirsutum , G. arboreum and G. raimondii respectively. LEA2 genes were classified into 6 groups, designated as group 1 to 6. Phylogenetic tree analysis revealed orthologous gene pairs within the cotton genome. The cotton specific LEA2 motifs identified were E, R and D in addition to Y, K and S motifs. The genes were distributed on all chromosomes. LEA2s were found to be highly enriched in non-polar, aliphatic amino acid residues, with leucine being the highest, 9...
June 22, 2018: G3: Genes—Genomes—Genetics
Mina S Makary, Summit H Shah, Rose J Miller, Steven P Doukides, Mark A King
RATIONALE AND OBJECTIVES: The aim of this study was to prospectively examine the impact of a tablet-based curriculum on the radiology resident educational experience. MATERIALS AND METHODS: A comprehensive tablet-based curriculum was developed by creating subspecialty modules with appropriate content level for each required rotation at our diagnostic radiology residency program. Daily assignments included key learning points, readings, and reference presentation slides, covering all objectives published by the ABR Core Exam Study Guide...
June 19, 2018: Academic Radiology
Christi M Barbee, Jessica A James, Jin Hyung Park, Emily M Smith, Carole E Johnson, Shari Clifton, Jeffrey L Danhauer
Standard audiometric evaluations are not sensitive enough to identify hidden hearing loss (HHL) and/or cochlear synaptopathy (CS). Patients with either of these conditions frequently present with difficulty understanding speech in noise or other complaints such as tinnitus. The purpose of this systematic review is to identify articles in peer-reviewed journals that assessed the sensitivity of audiologic measures for detecting HHL and/or CS, and which showed potential for use in a clinical test battery for these disorders...
May 2018: Seminars in Hearing
Joaquin T Valderrama, Elizabeth Francis Beach, Ingrid Yeend, Mridula Sharma, Bram Van Dun, Harvey Dillon
Recent animal studies have shown that the synapses between inner hair cells and the dendrites of the spiral ganglion cells they innervate are the elements in the cochlea most vulnerable to excessive noise exposure. Particularly in rodents, several studies have concluded that exposure to high level octave-band noise for 2 h leads to an irreversible loss of around 50% of synaptic ribbons, leaving audiometric hearing thresholds unaltered. Cochlear synaptopathy following noise exposure is hypothesized to degrade the neural encoding of sounds at the subcortical level, which would help explain certain listening-in-noise difficulties reported by some subjects with otherwise 'normal' hearing...
June 12, 2018: Hearing Research
Daniel Q Sun, C Blake Sullivan, Raymund W Kung, Megan Asklof, Marlan R Hansen, Bruce J Gantz
OBJECTIVE: To evaluate the association between signal changes during intraoperative audiologic monitoring and postoperative audiometric outcome in patients undergoing vestibular schwannoma (VS) resection via middle cranial fossa (MCF) approach. STUDY DESIGN: Retrospective chart review. SETTING: Academic tertiary referral center. PATIENTS: One hundred twenty-six consecutive patients (mean age 48.6 yrs, range 16-67; mean tumor size 9...
June 15, 2018: Otology & Neurotology
Sumru Keceli, Stefan Stenfelt
OBJECTIVE: To compare recordings of bone conduction (BC) stimulated auditory brainstem response (ABR) obtained using the newer BC transducer Radioear B81 and the conventional BC transducer Radioear B71. Balanced electromagnetic separation transducer (BEST) design found in the B81 may influence the ABR magnitudes and latencies, as well as electrical artefacts. DESIGN: ABRs to tone burst stimuli of 500 Hz, 2000 Hz, 4000 Hz, click stimulation, and broad-band chirp stimulation at 20 and 50 dB nHL were recorded...
June 18, 2018: International Journal of Audiology
Se-Jin Kim, Channy Park, Joon No Lee, Raekil Park
Cisplatin is an alkylating agent that interferes with DNA replication and kills proliferating carcinogenic cells. Several studies have been conducted to attenuate the side effects of cisplatin; one such side effect in cancer patients undergoing cisplatin chemotherapy is ototoxicity. However, owing to a lack of understanding of the precise mechanism underlying cisplatin-induced side effects, management of cisplatin-induced ototoxicity remains unsolved. We investigated the protective effects of fenofibrate, a PPAR-α activator, on cisplatin-induced ototoxicity...
June 13, 2018: Toxicology and Applied Pharmacology
Yang Dong, Chun-Rong Guo, Dan Chen, Sheng-Min Chen, Yinting Peng, Haiyan Song, Jian-Rong Shi
Accumulating evidence has revealed the link between age‑related hearing loss (presbycusis) and cognitive decline; however, their exact association remains unclear. The present study aimed to investigate the association between age‑related hearing loss and cognitive decline, and to explore the underlying mechanisms. Briefly, three groups of C57BL/6J mice were evaluated, based on their age, as follows: Young group, 3 months; adult group, 6 months; and middle‑aged group, 15 months. The results of an auditory brainstem response (ABR) test demonstrated that the hearing threshold levels of the mice were increased in those aged 6 and 15 months compared with those aged 3 months, thus suggesting that significant hearing loss occurred at 6 months, and worsened at 15 months...
June 1, 2018: Molecular Medicine Reports
Massimo Morfini, Stefano Gherardini
The improvement of clotting factor concentrates (CFCs) has undergone an impressive boost during the last six years. Since 2010, several new recombinant factor (rF)VIII/IX concentrates entered phase I/II/III clinical trials. The improvements are related to the culture of human embryonic kidney (HEK) cells, post-translational glycosylation, PEGylation, and co-expression of the fragment crystallizable (Fc) region of immunoglobulin (Ig)G1 or albumin genes in the manufacturing procedures. The extended half-life (EHL) CFCs allow an increase of the interval between bolus administrations during prophylaxis, a very important advantage for patients with difficulties in venous access...
June 2018: Therapeutic Advances in Hematology
Bouchra Edderkaoui, Liana Sargsyan, Alisa Hetrick, Hongzhe Li
Cochlear inflammatory response to various environmental insults, including acoustic and ototoxic overexposures, has been increasingly become a topic of interest. As the immune response is associated with both pathology and protection, targeting specific components of the immune response is expected to dissect the relationships between cellular damage and inflammation-associated protection and repair in the cochlea. Duffy antigen receptor for chemokines (DARC) is a member of a group of atypical chemokine receptors, and essential for chemokine-regulated leukocyte/neutrophil trafficking during inflammation...
2018: Frontiers in Molecular Neuroscience
Bo Yang, Hui Xu, Junfeng Wang, Dengming Yan, Qijun Zhong, Hexin Yu
In this study, an anaerobic baffled reactor (ABR) with four compartments was employed to treat alkali-decrement wastewater of polyester fabrics under different organic loading rates. The stable operation of this reactor was achieved in 70 days at a hydraulic retention time of 36 h and mesophilic temperature of 35 ± 1 °C. It is found that the chemical oxygen demand removal and decolorization of this system can be as high as 79.0% and 87.7%, respectively. The different acidogenesis and methanogenesis in four compartments was acclimated by the variation of pH, oxidation reduction potential values and operational conditions in the spatial distribution of the first to fourth compartments of the ABR system...
June 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Thomas M M Versluys, Robert A Foley, William J Skylark
Human mate choice is influenced by limb proportions. Previous work has focused on leg-to-body ratio (LBR) as a determinant of male attractiveness and found a preference for limbs that are close to, or slightly above, the average. We investigated the influence of two other key aspects of limb morphology: arm-to-body ratio (ABR) and intra-limb ratio (IR). In three studies of heterosexual women from the USA, we tested the attractiveness of male physiques that varied in LBR, ABR and IR, using figures that ranged from -3 to +3 standard deviations from the population mean...
May 2018: Royal Society Open Science
Kudamo Song, Sun Ae Shin, Dong Sik Chang, Ho Yun Lee
HYPOTHESIS: Patients with subjective nonpulsatile tinnitus and a normal conventional audiogram have more objective audiologic evidence of hidden hearing loss and deafferentation-related pathology than patients without tinnitus. BACKGROUND: The aim of this study was to assess the epidemiologic characteristics and audiologic profiles, including auditory brainstem response (ABR), distortion product otoacoustic emission, and threshold-equalizing noise test results, in patients with tinnitus and a normal audiogram...
July 2018: Otology & Neurotology
Rui Wu, Lina Duan, Jose Pruneda-Paz, Dong-Ha Oh, Michael P Pound, Steve A Kay, Jose R Dinneny
The water stress-associated hormone abscisic acid (ABA) acts through a well-defined signal transduction cascade to mediate downstream transcriptional events important for acclimation to stress. Although ABA signaling is known to function in specific tissues to regulate root growth, little is understood regarding the spatial pattern of ABA-mediated transcriptional regulation. Here we describe the construction and evaluation of an ABSCISIC ACID RESPONSIVE ELEMENT (ABRE)-based synthetic promoter reporter that reveals the transcriptional response of tissues to different levels of exogenous ABA and stresses...
June 8, 2018: Plant Physiology
Nadine Schart-Morén, Karin Hallin, Sumit K Agrawal, Hanif M Ladak, Per-Olof Eriksson, Hao Li, Helge Rask-Andersen
OBJECTIVES: Dehiscence between the cochlear otic capsule and the facial nerve canal is a rare and relatively newly described pathology. In cochlear implantation (CI), this dehiscence may lead to adverse electric facial nerve stimulation (FNS) already at low levels, rendering its use impossible. Here, we describe an assessment technique to foresee this complication. METHODS: Pre- and postoperative computed tomography (CT) scans and intraoperative electrically evoked auditory brainstem response (e-ABR) measurements were analyzed in two patients with cochlear-facial dehiscence (CFD)...
June 7, 2018: Cochlear Implants International
Jonas K Brännström, Wayne J Wilson, Sebastian Waechter
BACKGROUND: Despite the presence of efferent neural pathways from the cortex to brainstem, evidence for cognitive inhibition and sensory gating on the auditory brainstem has been mixed. Some previous studies have suggested auditory brainstem responses (ABR) can be affected by cognitive load whereas others have not. PURPOSE: The present study explores if the ABR recorded from adults with normal hearing was affected by increased cognitive load involving cognitive interference...
June 2018: Journal of the American Academy of Audiology
K Simpson, P Fuentes, L F Quiroz-Iturra, C Flores-Ortiz, R Contreras, M Handford, C Stange
Phytoene synthase (PSY) is the first committed enzyme of the carotenoid biosynthesis pathway and the most important point of regulation. Carotenoids are precursors of abscisic acid (ABA) which mediates abiotic stress tolerance responses in plants. ABA activates the synthesis of its own precursors through induction of PSY expression. Carrot, a specie that accumulates very high amounts of carotenoids in its reserve root, has two PSY paralog genes that are expressed differentially in the root. In this work we determined that DcPSY2 expression is induced by salt stress and ABA...
May 30, 2018: Journal of Experimental Botany
James J Finneran, Jason Mulsow, Dorian S Houser, Robert F Burkard
Although the auditory brainstem response (ABR) is known to be an onset response, specific features of acoustic stimuli that affect the morphology of the ABR are not well understood. In this study, the effects of stimulus onset properties were investigated by measuring ABRs in seven bottlenose dolphins while systematically manipulating stimulus rise time and the amplitude of the sound pressure temporal envelope plateau. Stimuli consisted of spectrally pink (i.e., equal mean-square pressure in proportional frequency bands) noise bursts with linear rise (and fall) envelopes and frequency content from 10 to 160 kHz...
May 2018: Journal of the Acoustical Society of America
Yukari Nagatoshi, Miki Fujita, Yasunari Fujita
Our transient gene expression analyses in Arabidopsis protoplasts support the view that CK2αs and CK2βs positively and negatively modulate ABRE-dependent gene expression, respectively. The phytohormone abscisic acid (ABA) regulates the expression of thousands of genes via ABA-responsive elements (ABREs), and has a crucial role in abiotic stress response. Casein kinase II (CK2), a conserved Ser/Thr protein kinase in eukaryotes, is essential for plant viability. Although the CK2 has been known as a tetrameric holoenzyme comprised of two catalytic α and two regulatory β subunits, each of the two types of subunits has been proposed to have independent functions...
May 24, 2018: Planta
Y L Hu, Z F Xia, P Chen, W Q Yue
Objective: To study the natural history of otitis media with effusion (OME) in infants, to guide clinical observation and treatment. Method: Newborns and infants born who failed newborn hearing screening and diagnosed OME were studied. Those with OME were diagnosed within 3 months old and followed-up. All subjects were examined with tympanometry once a month and with whole audiometric evaluation once three months. The causes, the time of recovery, and the disease course were analyzed in 46 infants followed-up at least 6 months...
August 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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