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https://www.readbyqxmd.com/read/27907086/stcdpk3-phosphorylates-in-vitro-two-transcription-factors-involved-in-ga-and-aba-signaling-in-potato-strsg1-and-stabf1
#1
Carolina Grandellis, Elisa Fantino, María Noelia Muñiz García, Magalí Graciela Bialer, Franco Santin, Daniela Andrea Capiati, Rita María Ulloa
Calcium-dependent protein kinases, CDPKs, decode calcium (Ca2+) transients and initiate downstream responses in plants. In order to understand how CDPKs affect plant physiology, their specific target proteins must be identified. In tobacco, the bZIP transcription factor Repression of Shoot Growth (NtRSG) that modulates gibberellin (GA) content is a specific target of NtCDPK1. StCDPK3 from potato is homologous (88% identical) to NtCDPK1 even in its N-terminal variable domain. In this work, we observe that NtRSG is also phosphorylated by StCDPK3...
2016: PloS One
https://www.readbyqxmd.com/read/27905208/effects-of-cisplatin-on-the-auditory-function-of-ovariectomized-rats-with-estrogen-deficiency
#2
Xu-Jun Hu, Fang-Fang Li, Ying Wang, Chi-Chuen Lau
CONCLUSION: The ovariectomy in rats does not change their auditory function. However, combining ovariectomy with Cisplatin treatment increases the risk of damaging the auditory function relative to the ototoxic effect caused by Cisplatin alone or ovariectomy alone. OBJECTIVES: The auditory benefit from estrogen depends on a number of factors that make findings among studies controversial. The present study was to examine the impact of Cisplatin, a chemotherapy drug, on the auditory function of ovariectomized rats...
December 1, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27904904/clinical-evaluation-of-glycopegylated-recombinant-fviii-efficacy-and-safety-in-severe-haemophilia-a
#3
Paul Giangrande, Tatiana Andreeva, Pratima Chowdary, Silke Ehrenforth, Hideji Hanabusa, Frank W G Leebeek, Steven R Lentz, Laszlo Nemes, Lone Hvitfeldt Poulsen, Elena Santagostino, Chur Woo You, Wan Hui Ong Clausen, Peter G Jönsson, Johannes Oldenburg
Turoctocog alfa pegol (N8-GP) is a novel glycoPEGylated extended half-life recombinant factor VIII (FVIII) product developed for prophylaxis and treatment of bleeds in patients with haemophilia A, to enable higher activity levels with less frequent injections compared with standard FVIII products. This phase III (NCT01480180), multinational, open-label, non-randomised trial evaluated the safety and clinical efficacy of N8-GP when administered for treatment of bleeds and for prophylaxis, in previously treated patients aged ≥12 years with severe haemophilia A...
December 1, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27904821/auditory-brainstem-response-and-late-latency-response-in-individuals-with-tinnitus-having-normal-hearing
#4
Sreeraj Konadath, Puttabasappa Manjula
Tinnitus is a commonly encountered complaint in routine audiology practice. The pathophysiology and exact generation site of tinnitus is not precisely established. Auditory brainstem response (ABR) and late latency response (LLR) findings in individuals with tinnitus show mixed results in the literature. Majority of studies have focused on individuals having tinnitus with peripheral hearing loss. The present study explores ABR and LLR characteristics among tinnitus patients with normal audiometric presentation; with no direct indication of any cochlear lesion...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27900890/dose-and-time-dependent-ototoxicity-of-aspartame-in-rats
#5
Orhan Ozturan, Remzi Dogan, Selahattin Tugrul, Ozge Gedik, Alev Pektas Sjostrand, Yavuz Selim Yildirim
CONCLUSION: Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased. OBJECTIVES: While Ap toxicity has been studied in short- and long-term studies, its effects on hearing have not been investigated. This study was conducted to evaluate the effects of long-term consumption of Ap administered in various doses on hearing status of rats...
November 30, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27897127/effects-of-noise-exposure-on-the-auditory-function-of-ovariectomized-rats-with-estrogen-deficiency
#6
Xujun Hu, Ying Wang, Chi Chuen Lau
OBJECTIVE: The benefits of estrogen for the auditory function of women depend on a number of factors. In this study, we aimed to examine the impact of noise trauma on the auditory function of ovariectomized rats with estrogen deficiency. MATERIALS AND METHODS: Twenty-eight young, female Sprague-Dawley rats were assigned to three groups (OVX+N, OVX-N, Sham+N). Rats in the OVX+N group and the OVX-N group underwent bilateral ovariectomy (OVX); the OVX+N group alone was also exposed to white noise (N) of 115 dB SPL for 8 hours a day over 14 days...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27897125/a-comparison-of-thresholds-of-auditory-steady-state-response-and-auditory-brainstem-response-in-healthy-term-babies
#7
Onur Çelik, Görkem Eskiizmir, Uzdan Uz
OBJECTIVE: The goal of this study was to assess the effectiveness of auditory steady-state response (ASSR), determine the cut-off values for each frequency, and detect the best correlated frequencies when compared with the auditory brainstem response (ABR) thresholds in term babies under the age of 12 months. MATERIALS AND METHODS: In total, 88 term babies with a mean age of 2.98 (1-11) months (174 ears) underwent ASSR and ABR tests. The ASSR thresholds for the frequencies of 500, 1000, 2000, and 4000 Hz were compared with the hearing level of the ABR thresholds...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27893606/cochlear-brainstem-and-psychophysical-responses-show-spectrotemporal-tradeoff-in-human-auditory-processing
#8
Gavin M Bidelman, Shaum P Bhagat
Auditory filter theory posits a tradeoff in time-frequency analysis: high temporal precision is achievable only at the expense of poorer frequency resolution and vice versa. Here, we examined the hierarchy of brain mechanisms of these spectrotemporal tradeoffs through a series of physiological and behavioral measures aimed to tap temporal and spectral acuity at different levels of the auditory neuroaxis (cochlea→brainstem→percept). Cochlear and behavioral frequency selectivity was measured by stimulus-frequency otoacoustic emissions (SFOAE) and psychophysical tuning curves; temporal acuity was measured physiologically and behaviorally by paired click recovery of auditory brainstem responses (ABRs) and gap detection thresholds (GDTs), respectively...
January 1, 2017: Neuroreport
https://www.readbyqxmd.com/read/27891689/deficit-in-acoustic-signal-in-noise-detection-in-glycine-receptor-%C3%AE-3-subunit-knockout-mice
#9
Konstantin Tziridis, Stefanie Buerbank, Volker Eulenburg, Julia Dlugaiczyk, Holger Schulze
Hearing is an essential sense for communication in animals and humans. Normal function of the cochlea of higher vertebrates relies on a fine-tuned interplay of afferent and efferent innervation of both inner and outer hair cells. Efferent inhibition is controlled via olivocochlear feedback loops, mediated mainly by acetylcholine, γ-aminobutyric acid (GABA) and glycine, and is one of the first sites affected by synapto- and neuropathy in the development of hearing loss. While the functions of acetylcholine, GABA, and other inhibitory transmitters within these feedback loops are at least partially understood, especially the function of glycine still remains elusive...
November 27, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27885871/continuous-prophylaxis-with-recombinant-factor-ix-fc-fusion-protein-and-conventional-recombinant-factor-ix-products-comparisons-of-efficacy-and-weekly-factor-consumption
#10
Alfonso Iorio, Sangeeta Krishnan, Karl-Johan Myrén, Stefan Lethagen, Nora McCormick, Sander Yermakov, Paul Karner
BACKGROUND: Continuous prophylaxis for patients with hemophilia B requires frequent injections that are burdensome and that may lead to suboptimal adherence and outcomes. Hence, therapies requiring less-frequent injections are needed. In the absence of head-to-head comparisons, we compared the first extended-half-life-recombinant factor IX (rFIX) product- recombinant factor IX Fc fusion protein (rFIXFc) - with conventional rFIX products based on annualized bleed rates (ABRs) and factor consumption reported in studies of continuous prophylaxis...
November 25, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27885514/speech-evoked-auditory-brainstem-response-and-gap-detection-threshold-in-middle-aged-individual
#11
Himanshu Kumar Sanju, Vaishnavi Bohra, Sujeet Kumar Sinha
This study aimed at characterizing the gap detection threshold (GDT) and speech evoked ABR (SABR) in younger and middle-aged individuals. Two groups of subjects were participated in the study which includes 15 young adults in the age range of 15-25 years and 15 middle-aged individuals in the age range of 40-60 years. SABR with stimulus/da/of 40 ms and GDT were investigated on both groups. For SABR, Mann-Whitney U test revealed that ageing has significantly adverse effect on the encoding of F1 and F2 at brainstem level...
November 24, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27885445/limited-ventricular-preload-is-the-main-reason-for-reduced-stress-reserve-after-atrial-baffle-repair
#12
Andreas Eicken, Julia Michel, Alfred Hager, Daniel Tanase, Harald Kaemmerer, Julie Cleuziou, John Hess, Peter Ewert
The atrial baffle repair (ABR) significantly improved the fate of patients with transposition of the great arteries (TGA). However, these patients show impaired exercise tolerance and some present severe decline of systemic ventricular function. Intrinsic myocardial weakness, low heart rate response to exercise and diastolic filling impairment are discussed to be causative. Forty-nine long-term survivors with TGA (median age 23.7 year) after ABR were catheterized with measured oxygen consumption in four conditions (baseline, volume, atrial pacing, dobutamine) and the results were compared to 10 normal controls...
November 24, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27884735/elderly-listeners-with-low-intelligibility-scores-under-reverberation-show-degraded-subcortical-representation-of-reverberant-speech
#13
H Fujihira, K Shiraishi, G B Remijn
In order to elucidate why many elderly listeners have difficulty understanding speech under reverberation, we investigated the relationship between word intelligibility and auditory brainstem responses (ABRs) in 28 elderly listeners. We hypothesized that the elderly listeners with low word intelligibility scores under reverberation would show degraded subcortical encoding information of reverberant speech as expressed in their ABRs towards a reverberant /da/ syllable. The participants were divided into two groups (top and bottom performance groups) according to their word intelligibility scores for anechoic and reverberant words, and ABR characteristics between groups were compared...
November 21, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27879227/correlation-between-cvemp-and-abr-for-the-evaluation-of-vestibular-migraine
#14
Mehmet Sürmeli, Reyhan Sürmeli, İldem Deveci, Serap Önder, Ayşe Destina Yalçın, Çağatay Oysu
OBJECTIVE: Vestibular migraine (VM) is a clinical condition characterized by temporal overlap between vestibular symptoms and migraine. In this study, we aimed to determine the changes in vestibular myogenic potential (cVEMP) and auditory brainstem response (ABR) in patients with VM and migraine. MATERIALS AND METHODS: A total of 86 participants with no hearing loss or additional disease between the ages of 18 and 45 were enrolled in three different groups: group 1, VM; group 2, migraine without aura; and group 3, healthy controls...
November 23, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27879226/speech-evoked-auditory-brainstem-response-in-individuals-with-diabetes-mellitus-type-2
#15
Himanshu Kumar Sanju, Akhil Mohanan, Prawin Kumar
OBJECTIVE: Diabetes is the most common glucose level dependent metabolic disorder and studies have shown that hearing impairment can be a long-term subclinical complication. Studies to investigate auditory system involvement in diabetes has focused majorly on the auditory brainstem response (ABR), otoacoustic emission, and basic audiological measures. Hence in the current study, we used speech-evoked ABR (S-ABR) as a tool to see the effect of diabetes on both a transient and sustained response of the auditory brainstem to a conventionally used consonant-vowel (CV) stimuli /da/...
November 23, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27865708/effects-of-exposure-to-2100mhz-gsm-like-radiofrequency-electromagnetic-field-on-auditory-system-of-rats
#16
Metin Çeliker, Abdulkadir Özgür, Levent Tümkaya, Suat Terzi, Mustafa Yılmaz, Yıldıray Kalkan, Ender Erdoğan
INTRODUCTION: The use of mobile phones has become widespread in recent years. Although beneficial from the communication viewpoint, the electromagnetic fields (EMF) generated by mobile phones may cause unwanted biological changes in the human body. OBJECTIVE: In this study, we aimed to evaluate the effects of 2100MHz Global System for Mobile communication (GSM-like) electromagnetic field (EMF), generated by an EMF generator, on the auditory system of rats by using electrophysiological, histopathologic and immunohistochemical methods...
November 5, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27863929/global-trends-in-adolescent-fertility-1990-2012-in-relation-to-national-wealth-income-inequalities-and-educational-expenditures
#17
John S Santelli, Xiaoyu Song, Samantha Garbers, Vinit Sharma, Russell M Viner
PURPOSE: National wealth, income inequalities, and expenditures on education can profoundly influence the health of a nation's women, children, and adolescents. We explored the association of trends in national socioeconomic status (SES) indicators with trends in adolescent birth rates (ABRs), by nation and region. METHODS: An ecologic research design was employed using national-level data from the World Bank on birth rates per 1,000 women aged 15-19 years, national wealth (per capita gross domestic product or GDP), income inequality (Gini index), and expenditures on education as a percentage of GDP (EduExp)...
October 27, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27863646/regenerative-efficacy-of-mesenchymal-stromal-cells-from-human-placenta-in-sensorineural-hearing-loss
#18
Kicheol Kil, Mi Young Choi, Ji Sun Kong, Woo Jin Kim, Kyoung Ho Park
INTRODUCTION: Hearing loss is a common chronic disorder characterized by decline of auditory function. The global population have suffered from deafness and the transplantation of stem cells is regarded as a therapeutic strategy for this disease. METHODS: We collected placenta from a total of 13 samples of full term pregnant women and isolated MSCs derived from human placenta and transplanted MSCs on deaf animal model. The normal group and the sensorineural hearing loss (SNHL) group and the experimental (transplanted MSCs) group were compared and estimated hearing level using auditory brainstem response (ABR) recordings and the otoacoustic emission (OAE) test...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27863636/the-effect-of-propofol-infusion-with-topical-epinephrine-on-cochlear-blood-flow-and-hearing-an-experimental-study
#19
Chul Ho Jang, Yong Beom Cho, Jun Sik Lee, Geun Hyung Kim, Won-Kyo Jung, Sok Cheon Pak
BACKGROUND AND OBJECTIVE: Propofol is the most commonly used intravenous (IV) anesthetic agent and is associated with hypotension upon induction of anesthesia. Intravenous propofol infusion has several properties that may be beneficial to patients undergoing middle ear surgery. Topical application of concentrated epinephrine is a valuable tool for achieving hemostasis in the middle ear and during mastoid surgery. The purpose of the present study was to determine the effects of propofol infusion with topical epinephrine on cochlear blood flow (CBF) and hearing in rats...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27862478/reductions-in-cortical-alpha-activity-enhancements-in-neural-responses-and-impaired-gap-detection-caused-by-sodium-salicylate-in-awake-guinea-pigs
#20
Joel I Berger, Ben Coomber, Mark N Wallace, Alan R Palmer
Tinnitus chronically affects between 10-15% of the population but despite its prevalence, the underlying mechanisms are still not properly understood. One experimental model involves administration of high doses of sodium salicylate, as this is known to reliably induce tinnitus in both humans and animals. Guinea pigs were implanted with chronic electrocorticography (ECoG) electrode arrays, with silver ball electrodes placed on the dura over left and right auditory cortex. Two more electrodes were positioned over the cerebellum to monitor auditory brainstem responses (ABRs)...
November 12, 2016: European Journal of Neuroscience
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