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https://www.readbyqxmd.com/read/29049277/update-interim-guidance-for-the-diagnosis-evaluation-and-management-of-infants-with-possible-congenital-zika-virus-infection-united-states-october-2017
#1
Tolulope Adebanjo, Shana Godfred-Cato, Laura Viens, Marc Fischer, J Erin Staples, Wendi Kuhnert-Tallman, Henry Walke, Titilope Oduyebo, Kara Polen, Georgina Peacock, Dana Meaney-Delman, Margaret A Honein, Sonja A Rasmussen, Cynthia A Moore
CDC has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection (1) in response to recently published updated guidance for health care providers caring for pregnant women with possible Zika virus exposure (2), unknown sensitivity and specificity of currently available diagnostic tests for congenital Zika virus infection, and recognition of additional clinical findings associated with congenital Zika virus infection. All infants born to mothers with possible Zika virus exposure* during pregnancy should receive a standard evaluation at birth and at each subsequent well-child visit including a comprehensive physical examination, age-appropriate vision screening and developmental monitoring and screening using validated tools (3-5), and newborn hearing screen at birth, preferably using auditory brainstem response (ABR) methodology (6)...
October 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29044825/pattern-of-bleeding-in-a-large-prospective-cohort-of-haemophilia-a-patients-a-three-year-follow-up-of-the-ahead-advate-in-haemophilia-a-outcome-database-study
#2
K Khair, M G Mazzucconi, R Parra, E Santagostino, D A Tsakiris, C Hermans, J Oldenburg, G Spotts, K Steinitz-Trost, A Gringeri
INTRODUCTION: Outcome data on treatment of patients with haemophilia A spanning several years of real-world evidence collection are currently very limited. AIM AND METHODS: The global prospective long-term Advate(®) Haemophilia A Outcome Database (AHEAD) cohort study collects real-world data from patients with severe and moderate haemophilia. We report an interim data read-out after three years of observation. RESULTS: A total of 522 patients were enrolled from 21 countries: 334 completed year 1 follow-up, 238 completed year 2 and 136 completed year 3, with an overall follow-up of 811 patient-years...
October 17, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29042071/influence-of-ginkgo-biloba-extract-egb-761-on-expression-of-il-1-beta-il-6-tnf-alfa-hsp-70-hsf-1-and-cox-2-after-noise-exposure-in-the-rat-cochlea
#3
Remzi Dogan, Alev Pektas Sjostrand, Alper Yenıgun, Ersin Karatas, Abdurrahim Kocyigit, Orhan Ozturan
OBJECTIVE: The objective of this study was to investigate the influence of Ginkgo Biloba in early treatment of noise induced hearing loss on expression of IL-6, IL-1 Beta, TNF-alfa, HSP-70, HSF-1 and COX-2 in the rat cochlea. METHODS: Thirty two female rats were randomly divided into four groups (Acoustic Trauma, Ginkgo Biloba, Acoustic Trauma+Ginkgo Biloba, Non Treatment). Auditory brainstem response (ABR) was applied in all the groups. At the end of the study, IL-1Beta, IL-6, TNF-alpha, HSP-70, HSF-1 and COX-2 were studied in cochlear tissue with ELISA and Western blot analysis...
October 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29038666/study-of-methylene-blue-ototoxicity-in-the-guinea-pig
#4
Sarah Belhassen, Musaed Alzahrani, Marc-Elie Nader, Louis Gaboury, Issam Saliba
BACKGROUND: Methylene blue is widely used in the medical field, especially as a blue dye for staining. It is also used as a photosensitizing agent in antimicrobial photodynamic therapy, which once photoactivated is effective for the eradication of several multi-resistant bacteria. The objective of this study was to investigate the ototoxic potential of methylene blue and precise its use in otology. METHODS: It was a prospective animal study performed on guinea pigs in our tertiary medical center...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29035674/the-startup-performance-and-microbial-distribution-of-an-anaerobic-baffled-reactor-abr-treating-medium-strength-synthetic-industrial-wastewater
#5
Hao Jiang, Hong Nie, Jiangtao Ding, Walter Stinner, Kaixuan Sun, Hongjun Zhou
In this study, an anaerobic baffled reactor (ABR) with seven chambers was applied to treat medium-strength synthetic industrial wastewater (MSIW). The performance of startup and shock test on treating MSIW was investigated. During the acclimation process, the chemical oxygen demand (COD) of MSIW gradually increased from 0 to 2,000 mg L(-1), and the COD removal finally reached 90%. At shock test, the feeding COD concentration increased by one-fifth and the reactor adapted very well with a COD removal of 82%...
October 16, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29031607/hearing-without-neuroglobin
#6
Manuela Nowotny, Lenneke Kiefer, Daniel Andre, Thomas Hankeln, Stefan Reuss
Neuroglobin is a member of the globin family of respiratory proteins, which was recently observed in many neurons of the auditory pathways. Up to now, however, nothing was known about the role of neuroglobin in hearing processes. We therefore studied auditory function by recording distortion-product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR) in wild-type (C57BL/6N) and neuroglobin-knockout mice. In KO mice, DPOAE thresholds were moderately augmented in the range of 5-18 kHz, reaching statistical significance at 8 and 10 kHz, while the ABR thresholds were not different between groups...
October 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/29027038/rescue-of-outer-hair-cells-with-antisense-oligonucleotides-in-usher-mice-is-dependent-on-age-of-treatment
#7
Abhilash Ponnath, Frederic F Depreux, Francine M Jodelka, Frank Rigo, Hamilton E Farris, Michelle L Hastings, Jennifer J Lentz
The absence of functional outer hair cells is a component of several forms of hereditary hearing impairment, including Usher syndrome, the most common cause of concurrent hearing and vision loss. Antisense oligonucleotide (ASO) treatment of mice with the human Usher mutation, Ush1c c.216G>A, corrects gene expression and significantly improves hearing, as measured by auditory-evoked brainstem responses (ABRs), as well as inner and outer hair cell (IHC and OHC) bundle morphology. However, it is not clear whether the improvement in hearing achieved by ASO treatment involves the functional rescue of outer hair cells...
October 12, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29026263/effects-of-recreational-noise-on-threshold-and-suprathreshold-measures-of-auditory-function
#8
REVIEW
Angela N C Fulbright, Colleen G Le Prell, Scott K Griffiths, Edward Lobarinas
Noise exposure that causes a temporary threshold shift but no permanent threshold shift can cause degeneration of synaptic ribbons and afferent nerve fibers, with a corresponding reduction in wave I amplitude of the auditory brainstem response (ABR) in animals. This form of underlying damage, hypothesized to also occur in humans, has been termed synaptopathy , and it has been hypothesized that there will be a hidden hearing loss consisting of functional deficits at suprathreshold stimulus levels. This study assessed whether recreational noise exposure history was associated with smaller ABR wave I amplitude and poorer performance on suprathreshold auditory test measures...
November 2017: Seminars in Hearing
https://www.readbyqxmd.com/read/29022419/speech-evoked-auditory-brainstem-response-with-ipsilateral-noise-in-adults-with-unilateral-hearing-loss
#9
Nihal Mohamed Abd El-Ghaffar, Amani Mohamed El-Gharib, Enaas A Kolkaila, Trandil Hassan Elmahallawy
INTRODUCTION: Subjects with unilateral hearing loss (UHL) report difficulties in speech understanding in noise. Speech-evoked auditory brainstem response (S-ABR) provides cues for temporal and spectral encoding of speech in the brainstem. S-ABR recording in noise increases its sensitivity in evaluating the auditory processing and related disorders. OBJECTIVES: Study speech encoding at the level of brainstem when the auditory system relies on one ear and to study the effect of noise on this encoding...
October 12, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29020454/the-absence-of-brain-specific-link-protein-bral2-in-perineuronal-nets-hampers-auditory-temporal-resolution-and-neural-adaptation-in-mice
#10
J Popelář, M Díaz Gómez, J Lindovský, N Rybalko, J Burianová, T Oohashi, J Syka
Brain-specific link protein Bral2 represents a substantial component of perineuronal nets (PNNs) enwrapping neurons in the central nervous system. To elucidate the role of Bral2 in auditory signal processing, the hearing function in knockout Bral2(-/-) (KO) mice was investigated using behavioral and electrophysiological methods and compared with wild type Bral2(+/+) (WT) mice. The amplitudes of the acoustic startle reflex (ASR) and the efficiency of the prepulse inhibition of ASR (PPI of ASR), produced by prepulse noise stimulus or gap in continuous noise, was similar in 2-week-old WT and KO mice...
October 11, 2017: Physiological Research
https://www.readbyqxmd.com/read/29020439/non-leachable-imidazolium-incorporated-composite-for-disruption-of-bacterial-clustering-exopolysaccharide-matrix-assembly-and-enhanced-biofilm-removal
#11
Geelsu Hwang, Bernard Koltisko, Xiaoming Jin, Hyun Koo
Surface-grown bacteria and production of an extracellular polymeric matrix modulate the assembly of highly cohesive and firmly attached biofilms, making them difficult to remove from solid surfaces. Inhibition of cell growth and inactivation of matrix-producing bacteria can impair biofilm formation and facilitate removal. Here, we developed a novel non-leachable antibacterial composite with potent antibiofilm activity by directly incorporating polymerizable imidazolium-containing resin (Anti Bacterial Resin with Carbonate linkage; ABR-C) into a methacrylate-based scaffold (ABR Modified Composite; ABR-MC) using an efficient yet simplified chemistry...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29018625/hearing-assessment-during-deep-brain-stimulation-of-the-central-nucleus-of-the-inferior-colliculus-and-dentate-cerebellar-nucleus-in-rat
#12
Jasper V Smit, Ali Jahanshahi, Marcus L F Janssen, Robert J Stokroos, Yasin Temel
BACKGROUND: Recently it has been shown in animal studies that deep brain stimulation (DBS) of auditory structures was able to reduce tinnitus-like behavior. However, the question arises whether hearing might be impaired when interfering in auditory-related network loops with DBS. METHODS: The auditory brainstem response (ABR) was measured in rats during high frequency stimulation (HFS) and low frequency stimulation (LFS) in the central nucleus of the inferior colliculus (CIC, n = 5) or dentate cerebellar nucleus (DCBN, n = 5)...
2017: PeerJ
https://www.readbyqxmd.com/read/29018492/air-and-bone-conduction-frequency-specific-auditory-brainstem-response-in-children-with-agenesis-of-the-external-auditory-canal
#13
Pricila Sleifer, Dayane Domeneghini Didoné, Ísis Bicca Keppeler, Claudine Devicari Bueno, Rudimar Dos Santos Riesgo
Introduction  The tone-evoked auditory brainstem responses (tone-ABR) enable the differential diagnosis in the evaluation of children until 12 months of age, including those with external and/or middle ear malformations. The use of auditory stimuli with frequency specificity by air and bone conduction allows characterization of hearing profile. Objective  The objective of our study was to compare the results obtained in tone-ABR by air and bone conduction in children until 12 months, with agenesis of the external auditory canal...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28993864/frequency-sensitivity-in-northern-saw-whet-owls-aegolius-acadicus
#14
Julia R Beatini, Glenn A Proudfoot, Megan D Gall
Northern saw-whet owls (Aegolius acadicus) are known for their unique asymmetrical ear structure and ability to localize prey acoustically, yet few attempts have been made to explore the auditory capabilities of this species. In this study, we evoked auditory brainstem responses (ABRs) with tonebursts to assess three main hypotheses regarding the evolution of auditory sensitivity: sender-receiver matching, ecological constraints, and phylogenetic/morphological constraints. We found that ABR amplitude increased with increasing stimulus level, which is consistent with results in other avian species...
October 9, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28983232/generation-and-characterization-of-%C3%AE-9-and-%C3%AE-10-nicotinic-acetylcholine-receptor-subunit-knockout-mice-on-a-c57bl-6j-background
#15
Barbara J Morley, David F Dolan, Kevin K Ohlemiller, Dwayne D Simmons
We generated constitutive knockout mouse models for the α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits by derivation from conditional knockouts by breeding with CRE deleter mice. We then backcrossed them onto a C57BL/6J genetic background. In this manuscript, we report the generation of the strains and an auditory phenotypic characterization of the constitutive α9 and α10 knockouts and a double α9α10 constitutive knockout. Although the α9 and α10 nAChR subunits are relevant to a number of physiological measures, we chose to characterize the mouse with auditory studies to compare them to existing but different α9 and α10 nAChR knockouts (KOs)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28971715/accuracy-of-averaged-auditory-brainstem-response-amplitude-and-latency-estimates
#16
Sara M K Madsen, James M Harte, Claus Elberling, Torsten Dau
OBJECTIVE: The aims were to 1) establish which of the four algorithms for estimating residual noise level and signal-to-noise ratio (SNR) in auditory brainstem responses (ABRs) perform better in terms of post-average wave-V peak latency and amplitude errors and 2) determine whether SNR or noise floor is a better stop criterion where the outcome measure is peak latency or amplitude. DESIGN: The performance of the algorithms was evaluated by numerical simulations using an ABR template combined with electroencephalographic (EEG) recordings obtained without sound stimulus...
October 3, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28964439/economic-burden-of-illness-among-persons-with-hemophilia-b-from-hugs-vb-examining-the-association-of-severity-and-treatment-regimens-with-costs-and-annual-bleed-rates
#17
MULTICENTER STUDY
Christina X Chen, Judith R Baker, Michael B Nichol
OBJECTIVES: To determine US societal burden of illness, including direct and indirect costs and annual bleed rate (ABR), for persons with hemophilia B (HB), a rare and debilitating genetic disorder, and to examine associations of hemophilia severity and treatment regimens with costs and ABR. METHODS: From 2009 to 2014, the Hemophilia Utilization Group Studies Part Vb collected prospective data from 10 US hemophilia treatment centers. Participants with HB completed initial surveys on sociodemographic characteristics, clinical characteristics, and treatment patterns...
September 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28958731/brainstem-infarction-associated-with-hhv-6-infection-in-an-infant
#18
Aya Wada, Kazuhiro Muramatsu, Yasuo Sunaga, Takahisa Mizuno, Mariko Takei, Satoshi Ogasawara, Miho Uchida, Kiwako Tsukida, Masahiko Tashiro
INTRODUCTION: The relevant literature includes several case reports on cerebral infarction in children with HHV-6 infection; however, there is no report of brain stem infarction. CASE: An 11-month-old girl was hospitalized because of fever. She was unable to stand up and meet her mother's gaze. Magnetic resonance imaging (MRI) indicated a right pons and mid-brain lesion; a diagnosis of brainstem infarction was made. After her fever subsided, a rash developed on her trunk and limbs; blood examination results indicated a primary HHV-6 infection...
September 25, 2017: Brain & Development
https://www.readbyqxmd.com/read/28955207/hydrogen-inhalation-protects-against-ototoxicity-induced-by-intravenous-cisplatin-in-the-guinea-pig
#19
Anette E Fransson, Marta Kisiel, Kristian Pirttilä, Curt Pettersson, Pernilla Videhult Pierre, Göran F E Laurell
Introduction: Permanent hearing loss and tinnitus as side-effects from treatment with the anticancer drug cisplatin is a clinical problem. Ototoxicity may be reduced by co-administration of an otoprotective agent, but the results in humans have so far been modest. Aim: The present preclinical in vivo study aimed to explore the protective efficacy of hydrogen (H2) inhalation on ototoxicity induced by intravenous cisplatin. Materials and Methods: Albino guinea pigs were divided into four groups. The Cispt (n = 11) and Cispt+H2 (n = 11) groups were given intravenous cisplatin (8 mg/kg b...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28951734/overexpression-of-pvpin1-a-bamboo-homolog-of-pin1-type-parvulin-1-delays-flowering-time-in-transgenic-arabidopsis-and-rice
#20
Zhigang Zheng, Xiaoming Yang, Yaping Fu, Longfei Zhu, Hantian Wei, Xinchun Lin
Because of the long and unpredictable flowering period in bamboo, the molecular mechanism of bamboo flowering is unclear. Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition by facilitating the cis/trans isomerization of the phosphorylated Ser/Thr residues preceding proline motifs in suppressor of overexpression of CO 1 (SOC1) and agamous-like 24 (AGL24). Whether bamboo has a Pin1 homolog and whether it works in bamboo flowering are still unknown...
2017: Frontiers in Plant Science
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