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Juan Wu, Jingya Li, Wei Li, Bei Sun, Jin Xie, Wenming Cheng, Qunlin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Sanmiao Wan (SMW) has been a basic prescription employed for the treatment for gout in the clinic since Yuan dynasty. Achyranthis bidentatae radix (ABR) is designed as a lower-guiding drug in SMW to augment the articular accumulation of active ingredients and improve the anti-inflammatory effect. AIM OF THE STUDY: Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR...
April 18, 2018: Journal of Ethnopharmacology
Ali Toolabi, Mohammad Malakootian, Mohammad Taghi Ghaneian, Ali Esrafili, Mohammad Hassan Ehrampoush, Mohsen AskarShahi, Maesome Tabatabaei
In this study, modeling and degradation of diazinon from contaminated water by advanced oxidation process together with a new test for effluent bioassay using E. coli were investigated. The experiments were designed based on response surface methodology. Nanoparticles (NPs) were synthesized using the sol-gel method. The shape characteristics and specifications of elements in the nanoparticles were characterized using scanning electron microscope and energy dispersive X-ray, respectively. Diazinon was measured using high performance liquid chromatography device and by-products due to its decomposition were identified by gas chromatography-mass (GC-MS)...
April 18, 2018: AMB Express
Ahmad Yeganeh Moghaddam, Mansour Sayyah, Elham Alian Fini, Rezvan Talaee
Introduction: Vitiligo is a common acquired depigmented systemic disorder influencing the entire pigmentary system including Cochlear melanocytes and vestibular system in the inner ear. Vitiligo can leads to social negative impact and poorer quality of life among these patients. This study was conducted to investigate the relationship between skin involvement severity and hearing loss severity among vitiligo patients. Methods: This cross-sectional study was performed on 98 patients with vitiligo referred to the dermatology clinic of Shahid Beheshti Hospital of Kashan during 2012-2014...
March 2018: Materia Socio-medica
Tian Yang, Ning Hu, Tina Pangršič, Steven Green, Marlan Hansen, Amy Lee
CaBPs are a family of Ca2+ binding proteins related to calmodulin. Two CaBP family members, CaBP1 and CaBP2, are highly expressed in the cochlea. Here, we investigated the significance of CaBP1 and CaBP2 for hearing in mice lacking expression of these proteins (CaBP1 KO and CaBP2 KO) using auditory brain responses (ABRs) and distortion product otoacoustic emissions (DPOAEs). In CaBP1 KO mice, ABR wave I was larger in amplitude, and shorter in latency and faster in decay, suggestive of enhanced synchrony of auditory nerve fibers...
April 9, 2018: Hearing Research
Emily K Rousham, Leanne Unicomb, Mohammad Aminul Islam
Antibiotic resistance (ABR) is recognized as a One Health challenge because of the rapid emergence and dissemination of resistant bacteria and genes among humans, animals and the environment on a global scale. However, there is a paucity of research assessing ABR contemporaneously in humans, animals and the environment in low-resource settings. This critical review seeks to identify the extent of One Health research on ABR in low- and middle-income countries (LMICs). Existing research has highlighted hotspots for environmental contamination; food-animal production systems that are likely to harbour reservoirs or promote transmission of ABR as well as high and increasing human rates of colonization with ABR commensal bacteria such as Escherichia coli However, very few studies have integrated all three components of the One Health spectrum to understand the dynamics of transmission and the prevalence of community-acquired resistance in humans and animals...
April 11, 2018: Proceedings. Biological Sciences
J C Roberts, S Lattimore, M Recht, S Jackson, D Gue, S Squire, K S Robinson, V Price, M Denne, S Richardson, K Rockwood
INTRODUCTION: To address the need for a patient-reported outcome that can measure clinically and personally meaningful change in people with haemophilia (PwH) on prophylaxis, an approach based on Goal Attainment Scaling (GAS) was developed: the GAS-Hēm. AIM: To establish real-world feasibility of GAS-Hēm in PwH. METHODS: Patients aged 5-65 years were enroled from four North American centres for a 12-week study. The primary outcome was the proportion of participants who completed GAS-Hēm interviews at baseline, 6 and 12 weeks...
April 6, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
Fabrice Giraudet, Perrine Charles, Thierry Mom, Odile Boespflug-Tanguy, Alexandra Dürr, Paul Deltenre, Paul Avan
OBJECTIVES: In patients with Friedreich ataxia (FRDA), mitochondrial failure leads to impaired cellular energetics. Since many FRDA patients have impaired hearing in noise, we investigated the objective consequences on standard auditory brainstem-evoked responses (ABRs). METHODS: In 37 FRDA patients, among whom 34 with abnormal standard ABRs, hearing sensitivity, speech-in-noise intelligibility and otoacoustic emissions were controlled. ABR recordings were split into four consecutive segments of the total time frame used for data collection, thus allowing the dynamics of ABR averaging to be observed...
March 27, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Yvonne S Sininger, Lisa L Hunter, Deborah Hayes, Patricia A Roush, Kristin M Uhler
OBJECTIVES: The first objective of this study was to compare the predicted audiometric thresholds obtained by auditory steady state response (ASSR) and auditory brainstem response (ABR) in infants and toddlers when both techniques use optimal stimuli and detection algorithms. This information will aid in determining the basis for large discrepancies in ABR and ASSR measures found in past studies. The hypothesis was that advancements in ASSR response detection would improve (lower) thresholds and decrease discrepancies between the thresholds produced by the two techniques...
April 5, 2018: Ear and Hearing
Lincoln L Berland, Nancy W Berland, Matthew W Berland
Changes in the certification program of the ABR were first described in some detail in 2008 and have since undergone refinements. Controversies surrounding these changes have included the relevance of test questions, costs, effects of altering the examination scheduling, residency program curriculum changes, and issues related to preparing for the examinations. However, the role of psychometric testing in radiology itself, as the technical foundation for the new ABR Core and Certification Examinations, has undergone less scrutiny...
March 31, 2018: Journal of the American College of Radiology: JACR
Katie Spielbauer, Lisa Cunningham, Nicole Schmitt
Immune checkpoint inhibition used in combination with standard cisplatin-based chemotherapy regimens is currently under evaluation in clinical trials for head and neck squamous cell carcinoma (HNSCC). The impact of anti-PD-1 therapy on cisplatin-induced ototoxicity and nephrotoxicity has not been established. Here we use a murine model of cisplatin-induced hearing loss to investigate the impact of anti-PD-1 immunotherapy on auditory brainstem responses (ABRs), distortion product otoacoustic emissions (DPOAEs), serum creatinine, and hair cell and renal histology...
March 1, 2018: Otolaryngology—Head and Neck Surgery
Yael Levit, Dror Mandel, Idit Matot
OBJECTIVE: Auditory brainstem response (ABR) testing is the gold-standard procedure for hearing evaluation in pediatric patients who cannot complete a behavioral hearing test. The amount of audiological information obtained depends on the quality of the patient's sleep during the test. In this retrospective database review, we aimed to assess the amount and the characteristics of the audiological information obtained in ABR testing in pediatric patients with age-appropriate sedation. METHODS: A retrospective chart review was conducted on 501 consecutive ABR sedation sessions performed between January 2014 and June 2016 at the Tel Aviv Medical Center...
May 2018: International Journal of Pediatric Otorhinolaryngology
Laurie Newton, Amanda Kotowski, Melissa Grinker, Robert Chun
OBJECTIVES: The aims of this project were two-fold: 1) To assess pediatric primary care (PCP), pediatric otolaryngology (ENT) and pediatric urgent care (UC) providers' perception of their adherence to the 2013 American Academy of Pediatrics (AAP) established guidelines for the diagnosis and management of acute bacterial rhinosinusitis (ABRS) in children 1-18 years old and 2) to assess the same providers' practice patterns in the diagnosis and management of pediatric chronic rhinosinusitis (PCRS)...
May 2018: International Journal of Pediatric Otorhinolaryngology
Nicole M Talge, Brooke M Tudor, Paul R Kileny
Behavior does not differentiate ASD risk prior to 12 months of age, but biomarkers may inform risk before symptoms emerge. Click-evoked auditory brainstem responses (ABRs) may be worth consideration due to their measurement properties (noninvasiveness; reliability) and conceptual features (well-characterized neural generators), but participant characteristics and assessment protocols vary considerably across studies. Our goal is to perform a meta-analysis of the association between ABRs and ASD. Following an electronic database search (PubMed, Medline, PsycInfo, PsycArticles), we included papers that were written in English, included ASD and typically-developing (TD) groups, and reported the information needed to calculate standardized mean differences (Hedges's g) for at least one ABR latency component (I, III, V, I-III, III-V, I-V)...
March 30, 2018: Autism Research: Official Journal of the International Society for Autism Research
Annie Zhuo, Maurizio Labbate, Jacqueline M Norris, Gwendolyn L Gilbert, Michael P Ward, Beata V Bajorek, Chris Degeling, Samantha J Rowbotham, Angus Dawson, Ky-Anh Nguyen, Grant A Hill-Cawthorne, Tania C Sorrell, Merran Govendir, Alison M Kesson, Jonathan R Iredell, Dale Dominey-Howes
OBJECTIVES: To explore and compare the knowledge, attitudes and experiences of doctors, dentists and veterinarians (as prescribers) in relation to antibiotic use and antibiotic resistance (AbR), and to consider the implications of these for policy-making that support a One Health approach. DESIGN: A cross-sectional survey conducted online. SETTING: Doctors, dentists and veterinarians practising in primary, secondary or tertiary care in Australia...
March 30, 2018: BMJ Open
Michael A Muniak, Femi E Ayeni, David K Ryugo
Reductions in sound-evoked activity in the auditory nerve due to hearing loss have been shown to cause pathological changes in central auditory structures. Hearing loss due strictly to the aging process are less well documented. In this study of CBA/CaH mice, we provide evidence for age-related pathology in the endbulb of Held, a large axosomatic ending arising from myelinated auditory nerve fibers. Endbulbs are known to be involved in the processing of temporal cues used for sound localization and speech comprehension...
March 20, 2018: Hearing Research
Michelle D Valero, Kenneth E Hancock, Stéphane F Maison, M Charles Liberman
Cochlear synaptopathy, i.e. the loss of auditory-nerve connections with cochlear hair cells, is seen in aging, noise damage, and other types of acquired sensorineural hearing loss. Because the subset of auditory-nerve fibers with high thresholds and low spontaneous rates (SRs) is disproportionately affected, audiometric thresholds are relatively insensitive to this primary neural degeneration. Although suprathreshold amplitudes of wave I of the auditory brainstem response (ABR) are attenuated in synaptopathic mice, there is not yet a robust diagnostic in humans...
March 13, 2018: Hearing Research
Sandra Schneider, Florian Salm, Szilvia Vincze, Anne Moeser, Inga Petruschke, Katja Schmücker, Norman Ludwig, Regina Hanke, Christin Schröder, Alexander Gropmann, Michael Behnke, Antina Lübke-Becker, Lothar H Wieler, Stefan Hagel, Mathias W Pletz, Jochen Gensichen, Petra Gastmeier
Background: Drivers of antibiotic (AB) resistance (ABR) include outpatient treatment, hospital care and animal husbandry. During the first phase of the One Health project RAI (Responsible Antibiotic Use via Information and Communication) surveys were conducted in these sectors. Objectives: To compare perceptions and attitudes towards ABR among general practitioners (GPs), hospital physicians, veterinarians, pig farmers and the general public. Methods: Cross-sectional questions on AB use and ABR were integrated in group-specific surveys of GPs, hospital physicians, veterinarians, pig farmers and the German general population...
March 26, 2018: Journal of Antimicrobial Chemotherapy
Bruno Henrique Schafhauser, Lauren A Kristofco, Cíntia Mara Ribas de Oliveira, Bryan W Brooks
Environmental observations of antibiotics and other pharmaceuticals have received attention as indicators of an urbanizing global water cycle. When connections between environment and development of antibiotic resistance (ABR) are considered, it is increasingly important to understand the life cycle of antibiotics. Here we examined the global occurrence of erythromycin (ERY) in: 1. wastewater effluent, inland waters, drinking water, groundwater, and estuarine and coastal systems; 2. sewage sludge, biosolids and sediments; and 3...
March 24, 2018: Environmental Pollution
L Rusen, K Kavakli, J Korth-Bradley, F Huard, P Rendo, J Fuiman, J A Baumann, L Smith, C Alvey, J Rupon
INTRODUCTION: The pharmacokinetics (PK), efficacy and safety of moroctocog alfa (AF-CC) have been demonstrated in haemophilia A patients aged ≥6 years. AIM: These studies aimed to further describe moroctocog alfa (AF-CC) experience in paediatric patients (<12 years) with severe haemophilia A (FVIII:C < 1%). METHODS: Two prospective, open-label studies enrolled patients aged <12 years: one study with 37 previously treated patients (PTPs) and another with 23 previously untreated patients (PUPs)...
March 26, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
A Klukowska, T Szczepański, V Vdovin, S Knaub, J Bichler, M Jansen, I Dzhunova, R J Liesner
INTRODUCTION: Nuwiq® (human-cl rhFVIII, simoctocog alfa) is a 4th generation recombinant human FVIII, without chemical modification or fusion with any other protein, produced in a human cell line. AIM/METHODS: This study (GENA-13) was an extension of the GENA-03 study in which previously treated children aged 2-12 years with severe haemophilia A received Nuwiq® prophylaxis for ≥6 months. GENA-13 examined long-term tolerability, immunogenicity and efficacy of Nuwiq® prophylaxis in children...
March 26, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
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