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https://www.readbyqxmd.com/read/29472062/computational-modeling-of-the-human-auditory-periphery-auditory-nerve-responses-evoked-potentials-and-hearing-loss
#1
REVIEW
Sarah Verhulst, Alessandro Altoè, Viacheslav Vasilkov
Models of the human auditory periphery range from very basic functional descriptions of auditory filtering to detailed computational models of cochlear mechanics, inner-hair cell (IHC), auditory-nerve (AN) and brainstem signal processing. It is challenging to include detailed physiological descriptions of cellular components into human auditory models because single-cell data stems from invasive animal recordings while human reference data only exists in the form of population responses (e.g., otoacoustic emissions, auditory evoked potentials)...
December 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/29471611/update-on-bone-conduction-auditory-brainstem-responses-a-review
#2
Young Joon Seo, Chanbeom Kwak, Saea Kim, Yoon Ah Park, Kyoung Ho Park, Woojae Han
Auditory brainstem responses (ABR) have been used as a powerful and the most common objective tool to evaluate hearing sensitivity and to diagnose the types of hearing loss and neurological disorders, through the auditory peripheral pathway to a central level of the brainstem, since 1971. Although bone-conduction (BC) ABR could be an alternative to air-conduction (AC) ABR, as the former overcomes some limitations of the latter, the majority of clinicians rarely utilize it due to a lack of knowledge and no routine test administration...
February 26, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29468051/the-knowledge-attitudes-and-practices-of-doctors-regarding-antibiotic-resistance-at-a-tertiary-care-institution-in-the-caribbean
#3
Alison Nicholson, Ingrid Tennant, Livingston White, Camille-Ann Thoms-Rodriguez, Loraine Cook, Stephen Johnson, Tamara Thompson, Jasper Barnett, Lundie Richards
Background: Antibiotic resistance (ABR) is a serious threat that requires coordinated global intervention to prevent its spread. There is limited data from the English-speaking Caribbean. Methods: As part of a national programme to address antibiotic resistance in Jamaica, a survey of the knowledge, attitudes and antibiotic prescribing practices of Jamaican physicians was conducted using a 32-item self-administered questionnaire. Results: Of the eight hundred physicians targeted, 87% responded...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29466997/hearing-impairment-in-melas-new-prospective-in-clinical-use-of-microrna-a-systematic-review
#4
REVIEW
Arianna Di Stadio, Valentina Pegoraro, Laura Giaretta, Laura Dipietro, Roberta Marozzo, Corrado Angelini
AIM: To evaluate the feasibility of microRNAs (miR) in clinical use to fill in the gap of current methodology commonly used to test hearing impairment in MELAS patients. MATERIAL AND METHOD: A literature review was performed using the following keywords, i.e., MELAS, Hearing Loss, Hearing Impairment, Temporal Bone, Otoacustic Emission (OTOAE), Auditory Brain Response (ABR), and microRNA. We reviewed the literature and focused on the aspect of the temporal bone, the results of electrophysiological tests in human clinical studies, and the use of miR for detecting lesions in the cochlea in patients with MELAS...
February 21, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29465485/enhanced-recovery-pathway-in-microvascular-autologous-tissue-based-breast-reconstruction-should-it-become-the-standard-of-care
#5
Christodoulos Kaoutzanis, Nishant Ganesh Kumar, Dillon O'Neill, Blair Wormer, Julian Winocour, John Layliev, Matthew McEvoy, Adam King, Stephane A Braun, K Kye Higdon
BACKGROUND: Enhanced Recovery Pathway (ERP) programs have demonstrated improved perioperative care and shorter length of hospital stay (LOS) in several surgical disciplines. The purpose of this study was to compare outcomes of patients undergoing autologous tissue-based breast reconstruction (ABR) before and after the implementation of an ERP program. METHODS: We retrospectively reviewed consecutive patients who underwent ABR by two surgeons before and after the implementation of the ERP at a university center over a three-year period...
February 9, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29459166/acute-blockade-of-inner-ear-marginal-and-dark-cell-k-secretion-effects-on-gravity-receptor-function
#6
Choongheon Lee, Timothy A Jones
Specific pharmacological blockade of KCNQ (Kv7) channels with XE991 rapidly (within 20 min) and profoundly alters inner ear gravity receptor responses to head motion (Lee et al., 2017). We hypothesized that these effects were attributable to the suppression of K+ secretion following blockade of KCNQ1-KCNE1 channels in vestibular dark cells and marginal cells. To test this hypothesis, K+ secretion was independently inhibited by blocking the Na+ -K+ -2Cl- cotransporter (NKCC1, Slc12a2) rather than KCNQ1-KCNE1 channels...
February 13, 2018: Hearing Research
https://www.readbyqxmd.com/read/29448295/recombinant-fxiii-rfxiii-a2-prophylaxis-prevents-bleeding-and-allows-for-surgery-in-patients-with-congenital-fxiii-a-subunit-deficiency
#7
Manuel Carcao, Carmen Altisent, Giancarlo Castaman, Katsuyuki Fukutake, Bryce A Kerlin, Craig Kessler, Riitta Lassila, Diane Nugent, Johannes Oldenburg, May-Lill Garly, Anders Rosholm, Aida Inbal
Recombinant factor XIII-A 2 (rFXIII-A 2 ) was developed for prophylaxis and treatment of bleeds in patients with congenital FXIII A-subunit deficiency. mentor™2 (NCT00978380), a multinational, open-label, single-arm, multiple-dosing extension to the pivotal mentor™1 trial, assessed long-term safety and efficacy of rFXIII-A 2 prophylaxis in eligible patients (patients with severe [<0.05 IU/mL] congenital FXIII subunit A deficiency) aged ≥6 years. Patients received 35 IU/kg rFXIII-A 2 (exact dosing) every 28 ± 2 days for ≥52 weeks...
February 15, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29445111/fluvastatin-protects-cochleae-from-damage-by-high-level-noise
#8
Claus-Peter Richter, Hunter Young, Sonja V Richter, Virginia Smith-Bronstein, Stuart R Stock, Xianghui Xiao, Carmen Soriano, Donna S Whitlon
Exposure to noise and ototoxic drugs are responsible for much of the debilitating hearing loss experienced by about 350 million people worldwide. Beyond hearing aids and cochlear implants, there have been no other FDA approved drug interventions established in the clinic that would either protect or reverse the effects of hearing loss. Using Auditory Brainstem Responses (ABR) in a guinea pig model, we demonstrate that fluvastatin, an inhibitor of HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway, protects against loss of cochlear function initiated by high intensity noise...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29435487/auditory-brainstem-responses-to-continuous-natural-speech-in-human-listeners
#9
Ross K Maddox, Adrian K C Lee
Speech is an ecologically essential signal, whose processing crucially involves the subcortical nuclei of the auditory brainstem, but there are few experimental options for studying these early responses in human listeners under natural conditions. While encoding of continuous natural speech has been successfully probed in the cortex with neurophysiological tools such as electroencephalography (EEG) and magnetoencephalography, the rapidity of subcortical response components combined with unfavorable signal-to-noise ratios signal-to-noise ratio has prevented application of those methods to the brainstem...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29431727/using-submersible-fluorescence-sensors-to-track-the-removal-of-organic-matter-in-decentralized-wastewater-treatment-systems-dewats-in-real-time
#10
N Mladenov, A Bigelow, B Pietruschka, M Palomo, C Buckley
Decentralized wastewater treatment systems (DEWATS) using anaerobic treatment are increasingly being considered for wastewater treatment with options for non-potable water reuse at the community scale. One challenge for ensuring performance and reliability of DEWATS is the lack of suitable on-site sensors to monitor failure or contamination events. In this study, the aim was to use in situ fluorescence sensors to track the performance of a DEWATS, consisting of an anaerobic baffled reactor (ABR) coupled to anaerobic filter (AF) and constructed wetland (CW) treatment processes...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29429180/-the-experimental-study-on-endoplasmic-reticulum-stress-participated-outer-hair-cell-apoptosis-in-cadherin-23-gene-mutant-mice
#11
J Hu, Z C Chen, Y Z Zhang, P Han, W J Ma, Q Zhang, M Xu
Objective: To test the mechanism and upstream pathway of outer hair cell apoptosis in Cadherin 23 (Cdh23) gene mutant mice. Method: The mutant Cdh23(erl/erl)(erl) mice were collected as the study group, while the C57BL/6J (B6) mice were chosen as the control group. A total of 70 mice per group were used in this study. The study group and control group underwent auditory-evoked brainstem response (ABR) tests at the same age. The terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay was performed to detect outer hair cell(OHC) apoptosis...
February 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29424820/the-antioxidant-effect-of-rosmarinic-acid-by-different-delivery-routes-in-the-animal-model-of-noise-induced-hearing-loss
#12
Anna R Fetoni, Sara Letizia Maria Eramo, Antonella Di Pino, Rolando Rolesi, Fabiola Paciello, Claudio Grassi, Diana Troiani, Gaetano Paludetti
HYPOTHESIS: Trans-tympanic Rosmarinic Acid (RA), as compared with the systemic administration, protects against noise-induced auditory hair cell and hearing losses in rats in vivo. BACKGROUND: ROS production, lipoperoxidative damage, and an imbalance of antioxidant defences play a significant role in noise-induced hearing loss. Several molecules with antioxidant properties have been tested to restore redox homeostasis; however, drug delivery system represents a challenge for their effectiveness...
March 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29419458/survey-of-programs-about-the-abr-16-month-nuclear-radiology-pathway-for-diagnostic-radiology-residents
#13
Jay A Harolds
No abstract text is available yet for this article.
February 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29409101/surgical-tips-for-the-management-of-the-wide-nasal-base
#14
Eric T Carniol, Peter A Adamson
Alar base reduction (ABR) was first described by Weir in 1892, but continues to be a controversial topic in rhinoplasty in terms of optimal techniques. The authors describe the techniques for ABR including internal, external and combined ABR, flare excisions, and alar hooding reductions. The techniques described have resulted in consistent outcomes with acceptable scarring and high patient satisfaction.
February 2018: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29405496/clinical-use-of-recombinant-factor-viii-fc-and-recombinant-factor-ix-fc-in-patients-with-haemophilia-a-and-b
#15
C Wang, G Young
INTRODUCTION: Although clinical trials have demonstrated extended half-life (EHL) VIII and IX fusion proteins to be safe and efficacious in patients with haemophilia A and B, studies on real-world clinical application have not been performed. AIM: To retrospectively examine the real-world experience of rFVIII Fc and rFIX Fc in patients. METHODS: A retrospective review of existing medical records of patients with haemophilia A or haemophilia B who had been prescribed rFVIII Fc or rFIX Fc was conducted from the Children's Hospital Los Angeles Haemostasis and Thrombosis Centre database...
February 5, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29402694/prenatal-organophosphate-insecticide-exposure-and-infant-sensory-function
#16
Monica K Silver, Jie Shao, Chai Ji, Binquan Zhu, Lin Xu, Mingyan Li, Minjian Chen, Yankai Xia, Niko Kaciroti, Betsy Lozoff, John D Meeker
BACKGROUND: Occupational studies suggest that exposure to organophosphate insecticides (OPs) can lead to vision or hearing loss. Yet the effects of early-life exposure on visual and auditory function are unknown. Here we examined associations between prenatal OP exposure and grating visual acuity (VA) and auditory brainstem response (ABR) during infancy. METHODS: 30 OPs were measured in umbilical cord blood using gas chromatography tandem mass spectrometry in a cohort of Chinese infants...
February 2, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29401063/test-retest-reliability-of-dual-recorded-brainstem-versus-cortical-auditory-evoked-potentials-to-speech
#17
Gavin M Bidelman, Monique Pousson, Calli Dugas, Amy Fehrenbach
BACKGROUND: Auditory-evoked potentials have proven useful in the objective evaluation of sound encoding at different stages of the auditory pathway (brainstem and cortex). Yet, their utility for use in clinical assessment and empirical research relies critically on the precision and test-retest repeatability of the measure. PURPOSE: To determine how subcortical/cortical classes of auditory neural responses directly compare in terms of their internal consistency and test-retest reliability within and between listeners...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29401057/effects-of-early-and-late-arriving-room-reflections-on-the-speech-evoked-auditory-brainstem-response
#18
Rida Al Osman, Christian Giguère, Hilmi R Dajani
BACKGROUND: Room reverberation alters the acoustical properties of the speech signals reaching our ears, affecting speech understanding. Therefore, it is important to understand the consequences of reverberation on auditory processing. In perceptual studies, the direct sound and early reflections of reverberated speech have been found to constitute useful energy, whereas the late reflections constitute detrimental energy. PURPOSE: This study investigated how various components (direct sound versus early reflections versus late reflections) of the reverberated speech are encoded in the auditory system using the speech-evoked auditory brainstem response (ABR)...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29392291/clinicians-guide-to-obtaining-a-valid-auditory-brainstem-response-to-determine-hearing-status-signal-noise-and-cross-checks
#19
Linda W Norrix, David Velenovsky
Purpose: The auditory brainstem response (ABR) is a powerful tool for making clinical decisions about the presence, degree, and type of hearing loss in individuals in whom behavioral hearing thresholds cannot be obtained or are not reliable. Although the test is objective, interpretation of the results is subjective. Method: This review provides information about evidence-based criteria, suggested by the 2013 Newborn Hearing Screening Program guidelines, and the use of cross-check methods for making valid interpretations about hearing status from ABR recordings...
February 1, 2018: American Journal of Audiology
https://www.readbyqxmd.com/read/29392065/possible-ototoxic-effects-of-topical-rifamycin-application-an-electrophysiological-and-ultrastructural-study
#20
Cihan Abaylı, Yusuf Kul, Muhsin Koten, Ahmet Rıfat Karasalihoğlu, Abdullah Taş, Recep Yağız, Erdoğan Bulut
Objective: This study aimed to investigate possible ototoxicity associated with topical rifamycin application via electrophysiological tests and ultrastructural examinations. Methods: Electrophysiological assessment was performed with tympanometry, auditory brainstem response (ABR), and distortion product otoacoustic emission (DPOAE) measurements. This study was conducted on 40 ears of 20 guinea pigs that were detected to have normal hearing thresholds. The animals were randomly assigned to three groups: Group 1 (n=12) received 0...
September 2017: Turkish Archives of Otorhinolaryngology
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