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https://www.readbyqxmd.com/read/29223865/prevention-of-ischemia-induced-hearing-loss-by-intravenous-administration-of-hydrogen-rich-saline-in-gerbil
#1
Hideo Ogawa, Masahiro Okada, Masachika Shudou, Kiyofumi Gyo, Naohito Hatoa
OBJECTIVE: Hydrogen-rich water, which is a potent antioxidant agent, was investigated for its protective effects against ischemic damage of the cochlea in gerbils. METHODS: The animals were subjected to transient cochlear ischemia by occluding the bilateral vertebral arteries for l5minutes. Five milliliters of hydrogen-rich saline was then intravenously administered immediately after the insult. Saline without hydrogen was used as a control. Effects of hydrogen were evaluated using the auditory brainstem response (ABR) and histological studies of the inner ear...
December 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29198184/impact-of-maternal-iron-deficiency-on-the-auditory-functions-in-the-young-and-adult-guinea-pig
#2
Nora Shero, Sylvain Fiset, Brian Blakley, Jean-Luc Jougleux, Marc E Surette, Mohamed Thabet, France M Rioux
OBJECTIVES: The aim of this study was to evaluate the hearing function in the guinea pig offspring at post-natal day (PNd) 24 and PNd84 born from dams suffering from iron deficiency during pregnancy and lactation by using the auditory brainstem response (ABR). METHOD: Female guinea pigs (n = 24 per dietary group) were fed an iron sufficient (IS) diet (114 mg/kg) or an iron deficient (ID) diet (11.7 mg/kg) during the gestation and lactation periods. Pups in both groups were weaned at PNd9 and given the IS diet...
December 3, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29195198/single-microbial-fuel-cell-reactor-for-coking-wastewater-treatment-simultaneous-carbon-and-nitrogen-removal-with-zero-alkaline-consumption
#3
Di Wu, Xiaoyun Yi, Rong Tang, Chunhua Feng, Chaohai Wei
The use of several individual reactors for sequential removal of organic compounds and nitrogen, in addition to the required alkaline addition in aerobic reactors, remain outstanding technical challenges to the traditional biological treatment of coking wastewater. Here, we report the utilization of a single microbial fuel cell (MFC) reactor that performs simultaneous carbon and nitrogen removal with zero alkaline consumption, as evidenced by the results of the batch-fed and continuous-flow experiments. The MFC exhibited faster reaction kinetics for COD and total nitrogen (TN) removal than the same configured reactor analogous to the traditional aerobic biological reactor (ABR)...
November 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29194866/break-through-bleeding-in-relation-to-pharmacokinetics-of-factor-viii-in-paediatric-patients-with-severe-haemophilia-a
#4
X Cheng, P Li, Z Chen, N Zhang, Y Zhen, L Zhao, X Wang, R Wu
INTRODUCTION: As the pharmacokinetics (PK) of factor VIII (FVIII) is individualized in children with haemophilia A (HA), PK parameters may be indicators of patients' bleeding phenotype and instruction for their personalized replacement program. AIM: The aim of this study was to investigate the possible relationship between PK/FVIII level and bleeding frequency in Chinese paediatric patients with severe (HA). METHODS: A total of 24 patients were enrolled in Beijing Children's Hospital from February to October 2015, all of whom were given 50 IU/kg of FVIII concentrates after a 72-hours washout period...
December 1, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29175767/effects-of-noise-overexposure-on-tone-detection-in-noise-in-nonhuman-primates
#5
Samantha N Hauser, Jane A Burton, Evan T Mercer, Ramnarayan Ramachandran
This report explores the consequences of acoustic overexposures on hearing in noisy environments for two macaque monkeys trained to perform a reaction time detection task using a Go/No-Go lever release paradigm. Behavioral and non-invasive physiological assessments were obtained before and after narrowband noise exposure. Physiological measurements showed elevated auditory brainstem response (ABR) thresholds and absent distortion product otoacoustic emissions (DPOAEs) post-exposure relative to pre-exposure...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29163046/rim-binding-protein-2-promotes-a-large-number-of-cav1-3-ca-2-channels-and-contributes-to-fast-synaptic-vesicle-replenishment-at-hair-cell-active-zones
#6
Stefanie Krinner, Tanvi Butola, SangYong Jung, Carolin Wichmann, Tobias Moser
Ribbon synapses of inner hair cells (IHCs) mediate high rates of synchronous exocytosis to indefatigably track the stimulating sound with sub-millisecond precision. The sophisticated molecular machinery of the inner hair cell active zone realizes this impressive performance by enabling a large number of synaptic voltage-gated CaV1.3 Ca(2+)-channels, their tight coupling to synaptic vesicles (SVs) and fast replenishment of fusion competent SVs. Here we studied the role of RIM-binding protein 2 (RIM-BP2)-a multidomain cytomatrix protein known to directly interact with Rab3 interacting molecules (RIMs), bassoon and CaV1...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29160156/prestin-as-an-otologic-biomarker-of-cisplatin-ototoxicity-in-a-guinea-pig-model
#7
James Naples, Robert Cox, Gregory Bonaiuto, And Kourosh Parham
Objective To evaluate (1) whether changes in serum prestin aid in early detection of cisplatin ototoxicity, (2) the role of diltiazem as an otoprotectant, and (3) whether prestin levels are sensitive to effects of diltiazem. Study Design Experimental animal study. Setting Translational research laboratory. Subjects Twenty female guinea pigs. Methods Two groups of 10 guinea pigs were used. The relationship between serum prestin levels and auditory brainstem response (ABR) thresholds was compared between the groups...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29157806/trigonelline-promotes-auditory-function-through-nerve-growth-factor-signaling-on-diabetic-animal-models
#8
Rodrigo Castañeda, Isabel Rodriguez, Youn Hee Nam, Bin Na Hong, Tong Ho Kang
BACKGROUND: Protection of cochlear function and reconstruction of neuronal networks in damaged auditory sensory structures is crucial for therapeutic treatment of diabetic hearing loss. Nerve growth factor (NGF) has been used as a novel therapeutic target to protect against the neurodegenerative effects of Diabetes Mellitus (DM). PURPOSE: We aimed to evaluate the potential effect of trigonelline (TRG) on reducing auditory damage produced by DM using NGF as a potential marker...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29154247/diagnostic-evaluation-of-neck-torsion-test-in-objective-examination-in-patients-with-vertigo-and-or-hearing-impairment
#9
Piotr Niewiadomski, Marzena Bielińska, Piotr Pietkiewicz, Jurek Olszewski
INTRODUCTION: The aim of the study was to evaluate the neck torsion test in objective examinations of patients with vertigo and/or hearing loss. MATERIAL AND METHODS: The study was conducted in 100 patients, including 54 women and 46 men aged 17-79 years, who were divided into two groups: I - 50 patients, including 30 women and 20 men aged 17-79 years (mean age 49.92 years) with dizziness and/or hearing impairments, and confirmed asymmetry of intracranial vessels, II - 50 patients - the control group, including 24 women and 26 men aged 20-71 years without dizziness and/or hearing disorders and without disturbance in the construction of intracranial vessels...
October 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29145496/insights-into-soybean-transcriptome-reconfiguration-under-hypoxic-stress-functional-regulatory-structural-and-compositional-characterization
#10
Thiago J Nakayama, Fabiana A Rodrigues, Norman Neumaier, Juliana Marcolino-Gomes, Hugo B C Molinari, Thaís R Santiago, Eduardo F Formighieri, Marcos F Basso, José R B Farias, Beatriz M Emygdio, Ana C B de Oliveira, Ângela D Campos, Aluízio Borém, Frank G Harmon, Liliane M Mertz-Henning, Alexandre L Nepomuceno
Soybean (Glycine max) is one of the major crops worldwide and flooding stress affects the production and expansion of cultivated areas. Oxygen is essential for mitochondrial aerobic respiration to supply the energy demand of plant cells. Because oxygen diffusion in water is 10,000 times lower than in air, partial (hypoxic) or total (anoxic) oxygen deficiency is important component of flooding. Even when oxygen is externally available, oxygen deficiency frequently occurs in bulky, dense or metabolically active tissues such as phloem, meristems, seeds, and fruits...
2017: PloS One
https://www.readbyqxmd.com/read/29139314/cost-utility-analysis-of-life-long-prophylaxis-with-recombinant-factor-viii-fc-vs-recombinant-factor-viii-for-the-management-of-severe-haemophilia-a-in-sweden
#11
Nathaniel Henry, Jelena Jovanović, Max Schlueter, Persefoni Kritikou, Koo Wilson, Karl-Johan Myrén
AIMS: Prophylaxis with recombinant factor VIII (rFVIII) is the standard of care for severe haemophilia A in Sweden. The need for frequent injections with existing rFVIII products may, however, result in poor adherence to prophylaxis leading to increased bleeding and long-term joint damage. Recombinant FVIIIFc (rFVIIIFc) is an extended half-life fusion protein which can offer prolonged protection and reduced dosing frequency. The objective of this study was to evaluate the cost-utility of prophylaxis with rFVIIIFc in severe haemophilia A from the perspective of the Swedish health system...
November 15, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/29130443/unraveling-the-mystery-of-auditory-brainstem-response-corrections-the-need-for-universal-standards
#12
REVIEW
Linda W Norrix, David Velenovsky
BACKGROUND: The auditory brainstem response (ABR) is used to estimate behavioral hearing thresholds in infants and difficult-to-test populations. Differences between the toneburst ABR and behavioral thresholds exist making the correspondence between the two measures less than perfect. Some authors have suggested that corrections be applied to ABR thresholds to account for these differences. However, because there is no agreed upon universal standard, confusion regarding the use of corrections exists...
November 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29125231/navigating-the-medical-physics-education-and-training-landscape
#13
Brian Loughery, George Starkschall, Kristi Hendrickson, Joann Prisciandaro, Brenda Clark, Gary Fullerton, Geoffrey Ibbott, Edward Jackson, Jay Burmeister
PURPOSE: The education and training landscape has been profoundly reshaped by the ABR 2012/2014 initiative and the MedPhys Match. This work quantifies these changes and summarizes available reports, surveys, and statistics on education and training. METHODS: We evaluate data from CAMPEP-accredited program websites, annual CAMPEP graduate and residency program reports, and surveys on the MedPhys Match and Professional Doctorate degree (DMP). RESULTS: From 2009-2015, the number of graduates from CAMPEP-accredited graduate programs rose from 210 to 332, while CAMPEP-accredited residency positions rose from 60 to 134...
November 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29116213/the-performance-and-archaeal-community-shifts-in-a-modified-anaerobic-baffled-reactor-treating-sweet-potato-starch-wastewater-at-ambient-temperatures
#14
Shengjun Xu, Cancan Jiang, Shuanglong Ma, Shanghua Wu, Zhihui Bai, Guoqiang Zhuang, Xuliang Zhuang
A conventional anaerobic baffled reactors (ABRs) treating high strength sweet potato starch wastewater at ambient temperatures resulted in acidification and bad performances. After modification, the acidification was remitted and COD removal efficiencies reached 92.73% at high temperatures and were maintained at 71.19% at low temperatures. Moreover, as much as 1.014 ± 0.056 L CH4/L/d were collected at Stage III. The q-PCR results revealed that the largest methanogen populations emerged at Stage III as well, which was 5...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29112884/appearance-based-rejection-sensitivity-as-a-mediator-of-the-relationship-between-symptoms-of-social-anxiety-and-disordered-eating-cognitions-and-behaviors
#15
Jake Linardon, Rachel Braithwaite, Rachel Cousins, Leah Brennan
Previous research has established a robust relationship between symptoms of social anxiety and disordered eating. However, the mechanisms that may underpin this relationship are unclear. Appearance-based rejection sensitivity (ABRS)-the tendency to anxiously expect and overreact to signs of appearance-based rejection-may be a crucial explanatory mechanism, as ABRS has been shown to maintain social anxiety symptoms and predict disordered eating. We therefore tested whether ABRS mediated the relationship between social anxiety symptoms and various indices of disordered eating (over-evaluation of weight/shape, restraint, binge eating, compulsive exercise, and vomiting)...
October 31, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/29108871/effects-of-the-cannabinoid-cb1-agonist-acea-on-salicylate-ototoxicity-hyperacusis-and-tinnitus-in-guinea-pigs
#16
Joel I Berger, Ben Coomber, Samantha Hill, Steve P H Alexander, William Owen, Alan R Palmer, Mark N Wallace
Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects caused by prior administration of salicylate, and potentially treat tinnitus. We recorded cortical resting-state activity, auditory-evoked cortical activity and auditory brainstem responses (ABRs), from chronically-implanted awake guinea pigs, before and after salicylate + ACEA...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29107847/the-fbn-rat-model-of-aging-investigation-of-abr-waveforms-and-ribbon-synapse-changes
#17
Rui Cai, Scott C Montgomery, Kaley A Graves, Donald M Caspary, Brandon C Cox
Age-related hearing loss is experienced by one-third of individuals aged 65 years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss of speech understanding, and loss of cochlear hair cells. We examined changes in ribbon synapse number at four different ages in Fisher Brown Norway rats, an extensively studied rat model of aging. In contrast to previous work in mice/Wistar rats, we found minimal ribbon synapse loss before 20 months, with significant differences in 24- and 28-month-old rats at 4 kHz...
October 9, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29106871/test-retest-reliability-of-speech-evoked-auditory-brainstem-response-in-healthy-children-at-a-low-sensation-level
#18
Mohd Normani Zakaria, Bahram Jalaei
OBJECTIVE: Auditory brainstem responses evoked by complex stimuli such as speech syllables have been studied in normal subjects and subjects with compromised auditory functions. The stability of speech-evoked auditory brainstem response (speech-ABR) when tested over time has been reported but the literature is limited. The present study was carried out to determine the test-retest reliability of speech-ABR in healthy children at a low sensation level. METHODS: Seventeen healthy children (6 boys, 11 girls) aged from 5 to 9 years (mean = 6...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29106479/establishing-a-distributed-national-research-infrastructure-providing-bioinformatics-support-to-life-science-researchers-in-australia
#19
Maria Victoria Schneider, Philippa C Griffin, Sonika Tyagi, Madison Flannery, Saravanan Dayalan, Simon Gladman, Nathan Watson-Haigh, Philipp E Bayer, Michael Charleston, Ira Cooke, Rob Cook, Richard J Edwards, David Edwards, Dominique Gorse, Malcolm McConville, David Powell, Marc R Wilkins, Andrew Lonie
EMBL Australia Bioinformatics Resource (EMBL-ABR) is a developing national research infrastructure, providing bioinformatics resources and support to life science and biomedical researchers in Australia. EMBL-ABR comprises 10 geographically distributed national nodes with one coordinating hub, with current funding provided through Bioplatforms Australia and the University of Melbourne for its initial 2-year development phase. The EMBL-ABR mission is to: (1) increase Australia's capacity in bioinformatics and data sciences; (2) contribute to the development of training in bioinformatics skills; (3) showcase Australian data sets at an international level and (4) enable engagement in international programs...
June 30, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29098103/cochlear-implantation-in-patients-with-keratitis-ichthyosis-deafness-syndrome-a-report-of-two-cases
#20
Birgul Gumus, Armagan Incesulu, Mehmet Ozgur Pinarbasli
Background: Keratitis-ichthyosis-deafness (KID) syndrome is a syndrome which presents with hearing loss and visual and keratinization disorders. In such patients, hearing aids cannot be effectively used in the rehabilitation of hearing loss because of the frequent blockage of the external ear canal with epithelial debris and due to dry and tense skin of the external ear canal. Moreover, severe or profound hearing loss also limits the benefits gained from the conventional hearing aids...
2017: Case Reports in Otolaryngology
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