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John P Marinelli, Christine M Lohse, Matthew L Carlson
OBJECTIVE: To describe the incidence of intralabyrinthine schwannoma (ILS) utilizing the Rochester Epidemiology Project (REP), a unique medical consortium in the United States that covers a complete population of all ages in a well-defined geographic area over the past half-century. PATIENTS: All patients with ILS diagnosed between January 1, 1966 and December 31, 2016 in Olmsted County, Minnesota, identified using the REP medical records-linkage system. MAIN OUTCOME MEASURES: Incidence of ILS...
June 15, 2018: Otology & Neurotology
Emily Zhang, Daniel H Coelho
OBJECTIVE: To study postoperative hearing outcomes in older adult cochlear implant recipients who did not meet Medicare candidacy criteria by sentence testing in quiet. STUDY DESIGN: Case Control Series. SETTING: University Based Tertiary Referral Cochlear Implant Center. PATIENTS: Fifty-four patients age 60 or greater with bilateral moderate to profound sensorineural hearing loss who underwent cochlear implantation...
June 15, 2018: Otology & Neurotology
Matthew G Crowson, Hillary Mulder, Derek D Cyr, Alan W Langman, Walter T Lee, Kourosh Parham, Melissa A Pynnonen, Kristine Schulz, Jennifer J Shin, David Witsell, Andrea Vambutas
OBJECTIVE: Given ongoing debate about the suggested association, the primary objective was to determine if idiopathic sudden sensorineural hearing loss (ISSNHL) was a sentinel event for acute myocardial infarction (AMI) in adults. STUDY DESIGN: Case-control study. SETTING: United States MarketScan administrative health claims database. PATIENTS: Aged 18 years or older, had a diagnosis of ISSNHL on or after January 1st, 2011 and had sufficient follow-up data available to assess for AMI occurrence...
June 15, 2018: Otology & Neurotology
Kyle T Fletcher, Erin M Wolf Horrell, John Ayugi, Catherine Irungu, Maria Muthoka, Liza M Creel, Cathy Lester, Matthew L Bush
OBJECTIVE: The purpose of this study was to examine the literature regarding the natural history and rehabilitative outcomes of sensorineural hearing loss from congenital cytomegalovirus infections. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: A systematic search was performed in PubMed, PsychINFO, CINAHL, and Web of Science to identify peer-reviewed research. Eligible studies were those containing original peer-reviewed research in English addressing either the natural history or rehabilitative outcomes of sensorineural hearing loss (SNHL) in congenital cytomegalovirus (cCMV)...
June 15, 2018: Otology & Neurotology
Liam Sutton, John T McElveen, Gerald Brookes, Azhar Shaida, Matt Lechner
No abstract text is available yet for this article.
July 2018: Annals of Otology, Rhinology, and Laryngology
Mia E Miller, Ivan A Lopez, Fred H Linthicum, Akira Ishiyama
HYPOTHESIS: Connexin-26 (Cx26) expression is diminished in the spiral ligament of subjects with hearing loss and cochlear otosclerosis (CO). BACKGROUND: Human temporal bone (HTB) studies have demonstrated that CO is associated with hyalinization of the spiral ligament. We hypothesize that hyalinization is associated with a loss of fibrocytes with a consequent decline in Cx26 expression. Cx26 and Connexin-30 (Cx30) encode gap junction proteins expressed in supporting cells of the organ of Corti, the spiral limbus, stria vascularis, and in fibrocytes of the spiral ligament...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
Wen-Yan Zhu, Xin Jin, Yong-Chi Ma, Zhi-Biao Liu
Ischemia and oxidative stress play crucial roles in the pathophysiology of sudden sensorineural hearing loss (SSNHL). Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and serves an important role in hearing function. The present study was designed to evaluate the effect of MIF on oxygen-glucose deprivation (OGD)-induced ototoxicity and to elucidate its molecular mechanism. In HEI-OC1 auditory cells, OGD reduced cell viability and increased supernatant lactate dehydrogenase (LDH) and MIF in a time-dependent manner...
June 13, 2018: Biochemical and Biophysical Research Communications
Kaley Woods, Percy Lee, Tania Kaprealian, Isaac Yang, Ke Sheng
Purpose: This study investigates whether 4π noncoplanar radiation therapy can spare the cochleae and consequently potentially improve hearing preservation in patients with acoustic neuroma who are treated with radiation therapy. Methods and materials: Clinical radiation therapy plans for 30 patients with acoustic neuroma were included (14 stereotactic radiation surgery [SRS], 6 stereotactic radiation therapy [SRT], and 10 intensity modulated radiation therapy [IMRT])...
April 2018: Advances in Radiation Oncology
Virginie Moulin, Francesco Grandoni, Julien Castioni, Henri Lu
Thiamine-responsive megaloblastic anaemia (TRMA) is a syndrome associated with megaloblastic anaemia, diabetes mellitus and sensorineural deafness, due to mutations in the SLC19A2 gene, which codes for a thiamine carrier protein. Oral thiamine supplementation is the main treatment. We report the case of a 25-year-old woman known for TRMA, who presented with pancytopenia (haemoglobin 7.6 g/dL, leucocytes 2.9×109 /L, thrombocytes 6×109 /L) revealed by dyspnoea. Investigations excluded coagulopathy, a recent viral infection, vitamin and iron deficiencies, and a malignant process...
June 14, 2018: BMJ Case Reports
Manjul Tripathi, Ayusman Satapathy, Ravi Bharatbhai Chauhan, Aman Batish, Sunil K Gupta
BACKGROUND: Resection of a vestibular schwannoma may result in facial paralyiss and hearing loss on the side of tumor. Authors have encountered a young female of neurofibromatosis type 2, who developed contralateral side sensorineural hearing loss immediately after resection of vestibular schwannoma.The patient regained partial hearing with a short course (2 months) of steroid therapy over 6 month. MATERIAL AND METHODS: Clinical, audiological, intraoperative events and radiological parameters were evaluated in this case...
June 11, 2018: World Neurosurgery
Sujay V Kharade, Haruto Kurata, Aaron Bender, Anna L Blobaum, Eric E Figueroa, Amanda M Duran, Meghan Kramer, Emily Days, Paige Vinson, Daniel Flores, Lisa M Satlin, Jens Meiler, C David Weaver, Craig W Lindsley, Corey R Hopkins, Jerod S Denton
The inward rectifier potassium (Kir) channel Kir4.1 (KCNJ10) carries out important physiological roles in epithelial cells of the kidney, astrocytes in the central nervous system, and stria vascularis of the inner ear. Loss-of-function mutations in KCNJ10 lead to EAST/SeSAME syndrome, which is characterized by epilepsy, ataxia, renal salt wasting, and sensorineural deafness. While genetic approaches have been indispensable for establishing the importance of Kir4.1 in the normal function of these tissues, the availability of pharmacological tools for acutely manipulating the activity of Kir4...
June 12, 2018: Molecular Pharmacology
Manuela Kobas, Myriam Bickle Graz, Anita Carmen Truttmann, Eric Giannoni, Pascal Meylan, Sandra Andrea Asner
BACKGROUND: Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown. AIMS OF THE STUDY: (1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection...
June 12, 2018: Swiss Medical Weekly
Hongcun Sun, Xiaowen Qiu, Jiandao Hu, Zhaoxin Ma
OBJECTIVE: This study aimed to compare the efficacy of intratympanic dexamethasone (ITD) therapy and hyperbaric oxygen(HBO) therapy for the salvage treatment of patients with high-frequency sudden sensorineural hearing loss (SSNHL) after the failure of conventional therapy. MATERIALS AND METHODS: 104 refractory high-frequency SSNHL patients were enrolled in our study. Among them, 31 received ITD alone (ITD group), 32 received HBO alone (HBO group) and 41 received no salvage therapies (control group)...
June 5, 2018: American Journal of Otolaryngology
Takamori Takeda, Yoshiyuki Kawashima, Chiaki Hirai, Ayane Makabe, Taku Ito, Taro Fujikawa, Katsura Yamamoto, Ayako Maruyama, Takeshi Tsutsumi
OBJECTIVE: To describe the vestibular function in patients with superficial siderosis of the central nervous system (SSCN). STUDY DESIGN: Retrospective analysis. SETTING: Tertiary referral center. PATIENTS: Ten consecutive patients with SSCN. This study is the largest case series of SSCN in which detailed neuro-otological findings, including electronystagmography recording, video head impulse test (vHIT), and posturography, were described...
July 2018: Otology & Neurotology
Jeroen P M Peters, Anne W Wendrich, Ruben H M van Eijl, Koenraad S Rhebergen, Huib Versnel, Wilko Grolman
HYPOTHESIS: A cochlear implant (CI) restores hearing in patients with profound sensorineural hearing loss by electrical stimulation of the auditory nerve. It is unknown how this electrical stimulation sounds. BACKGROUND: Patients with single-sided deafness (SSD) and a CI form a unique population, since they can compare the sound of their CI with simulations of the CI sound played to their nonimplanted ear. METHODS: We tested six stimuli (speech and music) in 10 SSD patients implanted with a CI (Cochlear Ltd)...
July 2018: Otology & Neurotology
Nian Zhang, Juan Wang, Shuting Liu, Mugen Liu, Fagang Jiang
BACKGROUND: To describe the clinical and genetic findings in a Chinese family with three sibs diagnosed with Usher syndrome type IIC. MATERIALS AND METHODS: Four members received ophthalmic and otologic tests to ascertain the clinical characteristics. According to the clinical phenotype, we focused attention on a total of 658 genes associated with them. We screened the possible pathogenic mutation sites, used Sanger to exclude the false positive and verified whether there were co-segregated among the family members...
June 8, 2018: Ophthalmic Genetics
Liza Maniquis-Smigel, Kenneth Dean Reeves, Howard Jeffrey Rosen, John Lyftogt, Cassie Graham-Coleman, An-Lin Cheng, David Rabago
OBJECTIVES: Chronic low-back pain (CLBP) participants in a prior controlled study reported short-term pain relief after caudal epidural injection of 5% dextrose (D5W). This study assessed whether repeated caudal epidural injections of D5W results in serial short-term diminution of CLBP and progressive long-term decrease in pain and disability. DESIGN: Prospective uncontrolled study. SETTINGS/LOCATION: Outpatient pain clinic. SUBJECTS: Adults with CLBP with radiation to gluteal or leg areas...
June 8, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Sebastian P Schraven, Kristen Rak, Mario Cebulla, Andreas Radeloff, Wilma Grossmann, Rudolf Hagen, Robert Mlynski
INTRODUCTION: Since 1996 the active middle-ear implant Vibrant Soundbridge (VSB) is used to treat mild-to-severe sensorineural hearing losses. The former standard surgical approach for incus vibroplasty included a mastoidectomy and a posterior tympanotomy, crimping the Floating-Mass Transducer (FMT) to the long incus process. The introduction of the short process (SP) coupler allows the attachment of the FMT to the incus body making the procedure of a posterior tympanotomy unnecessary...
June 6, 2018: Otology & Neurotology
Miguel Raimundo, Cristina Fonseca, Rufino Silva, João Figueira
PURPOSE: Alport syndrome is a rare condition characterized by the clinical triad of nephritic syndrome, sensorineural deafness, and ophthalmological alterations. Herein, we present a rare case of a patient diagnosed with Alport syndrome and bilateral giant macular holes. CASE DESCRIPTION: A 40-year-old woman with a previously unreported mutation in the COL4A4 gene suggestive of autosomal-recessive Alport syndrome presented at our department. The patient exhibited bilateral full-thickness macular holes measuring >1500 µm at their smallest diameters...
May 1, 2018: European Journal of Ophthalmology
G Gao, M H Qian, C Ji, M Yao
Objective: To investigate the therapeutic effect of psychological intervention combined with diazepam on sudden hearing loss patients with anxiety. Method: 108 cases of sudden hearing loss patients with anxiety were randomly divided into two groups( n =54 in each group): The control group received routine treatment of sudden hearing loss, the study group was given psychological intervention combined with diazepam tablets(2.5 mg once, twice a day) based on the routine treatment. The hearing and HAMA and SAS scores were reviewed after 10 days of treatment...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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