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Oligodendroglioma

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https://www.readbyqxmd.com/read/28915860/anatomic-mapping-of-molecular-subtypes-in-diffuse-glioma
#1
Qisheng Tang, Yuxi Lian, Jinhua Yu, Yuanyuan Wang, Zhifeng Shi, Liang Chen
BACKGROUND: Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular subtypes was not widely investigated. The relationship between molecular phenotype and histological subgroup were also vague based on tumor location. Our group focuses on the study of glioma anatomic location of distinctive molecular subgroups and histology subtypes, and explores the possibility of their consistency based on clinical background...
September 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28900829/clinical-radiological-pathological-and-prognostic-aspects-of-intraventricular-oligodendroglioma-comparison-with-central-neurocytoma
#2
Xiang Xiao, Jun Zhou, Jun Wang, Lei Yang, Chunhong Wang, Yikai Xu, Yuankui Wu
Studies comparing intraventricular oligodendroglioma (IVO) and central neurocytoma (CN) in terms of their clinical, radiological and pathological features are scarce. We, therefore, investigated the similarities and differences between these types of tumors to get a better understanding of how they may be more properly diagnosed and treated. The clinical manifestations, CT/MRI findings, pathological characteristics and clinical outcomes of 8 cases of IVOs and 12 cases of CNs were analyzed retrospectively. Both IVO and CN occurred most commonly in young adults and manifested with symptoms of increased intracranial pressure secondary to obstructive hydrocephalus...
September 12, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28894952/characterization-of-brain-tumours-with-spin-spin-relaxation-pilot-case-study-reveals-unique-t-2-distribution-profiles-of-glioblastoma-oligodendroglioma-and-meningioma
#3
Cornelia Laule, Thorarin A Bjarnason, Irene M Vavasour, Anthony L Traboulsee, G R Wayne Moore, David K B Li, Alex L MacKay
Prolonged spin-spin relaxation times in tumour tissue have been observed since some of the earliest nuclear magnetic resonance investigations of the brain. Over the last three decades, numerous studies have sought to characterize tumour morphology and malignancy using quantitative assessment of T 2 relaxation times, although attempts to categorize and differentiate tumours have had limited success. However, previous work must be interpreted with caution as relaxation data were typically acquired using a variety of multiple echo sequences with a range of echoes and T 2 decay curves and were frequently fit with monoexponential analysis...
September 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28885120/threshold-of-the-extent-of-resection-for-who-grade-iii-gliomas-retrospective-volumetric-analysis-of-122-cases-using-intraoperative-mri
#4
Yu Fujii, Yoshihiro Muragaki, Takashi Maruyama, Masayuki Nitta, Taiichi Saito, Soko Ikuta, Hiroshi Iseki, Kazuhiro Hongo, Takakazu Kawamata
OBJECTIVE WHO Grade III gliomas are relatively rare and treated with multiple modalities such as surgery, chemotherapy, and radiotherapy. The impact of the extent of resection (EOR) on improving survival in patients with this tumor type is unclear. Moreover, because of the heterogeneous radiological appearance of Grade III gliomas, the MRI sequence that best correlates with tumor volume is unknown. In the present retrospective study, the authors evaluated the prognostic significance of EOR. METHODS Clinical and radiological data from 122 patients with newly diagnosed WHO Grade III gliomas who had undergone intraoperative MRI-guided resection at a single institution between March 2000 and December 2011 were analyzed retrospectively...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28880421/diffuse-midline-gliomas-with-histone-h3-k27m-mutation-a-rare-case-with-pnet-like-appearance-and-neuropil-like-islands
#5
Yue Gao, Yang-Yang Feng, Juan-Han Yu, Qing-Chang Li, Xue-Shan Qiu, En-Hua Wang
Diffuse midline glioma with histone H3-K27M mutation is a new tumor entity defined by the 2016 WHO Classification of Tumors of the Central Nervous System. A 51-year-old Chinese woman presented with neck pain for a month. Subsequent MRI revealed an intramedullary neoplasm extending from C5 to C7. Histologically, the cellular area of the tumor was composed of primitive, poorly differentiated, small cells with scant cytoplasm, nuclear molding, and brisk mitotic activity, exhibiting PNET-like appearance, while in the hypocellular area, oligodendroglioma-like cells were observed...
September 6, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28870791/performance-of-knowledge-based-radiation-therapy-planning-for-the-glioblastoma-disease-site
#6
Avishek Chatterjee, Monica Serban, Bassam Abdulkarim, Valerie Panet-Raymond, Luis Souhami, George Shenouda, Siham Sabri, Bertrand Jean-Claude, Jan Seuntjens
PURPOSE: The presence of multiple serial organs at risk (OARs) in close proximity to the tumor makes treatment planning for glioblastoma (GBM) complex and time consuming. The present study aimed to create a knowledge-based (KB) radiation therapy model for GBM patients using RapidPlan. METHODS AND MATERIALS: An initial model was trained using 82 glioblastoma patients treated with 60 Gy in 30 fractions. Plans were created using either volumetric modulated arc therapy (VMAT) or intensity modulated radiation therapy (IMRT)...
July 14, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28870453/spinal-cord-tumors-in-children-a-review-of-21-cases-treated-at-the-same-institution
#7
I Merlot, J Francois, J-C Marchal, A Joud, R Guerbouz, P Chastagner, O Klein
INTRODUCTION: Spinal cord tumors in children (SCTC) are rare with a frequent diagnostic delay. Its management is multidisciplinary and challenging due to functional implications. The position of surgery is now better established but the role and timing of chemotherapy (CT) and radiotherapy (RT) still remains under debate. Adverse effects of treatments are important to be taken into account, in the follow-up of these children. The aim of this paper was to present a series of 21 cases of SCTC treated at the same institution, to briefly present clinical features, treatments and outcome, with a special focus on spinal deformities in children with this condition...
September 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28867318/case-report-of-regression-of-recurrent-high-grade-glioma-with-temozolomide-dexamethasone-and-levetiracetam-and-review-of-literature
#8
Ajaya Kumar A, Abu Abraham Koshy
Treatment options for recurrent glioma of brain include chemotherapy, radiotherapy, surgery and palliation. Temozolomide appears to be effective in patients with recurrent high grade gliomas. A middle aged lady had high grade glioma of corpus callosum. Tumour was excised and chemo radiation was given. It was grade 3 anaplastic oligodendroglioma. After 5 years she had significant recurrence. They were not willing for repeat surgery or radiation. She was given temozolomide and dexamethasone intermittently and levetiracetam was continued...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28865921/in-vivo-assessment-of-tumor-heterogeneity-in-who-2016-glioma-grades-using-diffusion-kurtosis-imaging-diagnostic-performance-and-improvement-of-feasibility-in-routine-clinical-practice
#9
J-M Hempel, J Schittenhelm, S Bisdas, C Brendle, B Bender, G Bier, M Skardelly, G Tabatabai, S Castaneda Vega, U Ernemann, U Klose
PURPOSE: To assess the diagnostic performance of normalized and non-normalized diffusion kurtosis imaging (DKI) metrics extracted from different tumor volume data for grading glioma according to the integrated approach of the revised 2016 WHO classification. MATERIALS AND METHODS: Sixty patients with histopathologically confirmed glioma, who provided written informed consent, were retrospectively assessed between 01/2013 and 08/2016 from a prospective trial approved by the local institutional review board...
September 1, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28862024/differentiation-of-grade-ii-and-iii-oligodendrogliomas-from-grade-ii-and-iii-astrocytomas-a-histogram-analysis-of-perfusion-parameters-derived-from-dynamic-contrast-enhanced-dce-and-dynamic-susceptibility-contrast-dsc-mri
#10
Ji Young Lee, Kook Jin Ahn, Youn Soo Lee, Jin Hee Jang, So Lyung Jung, Bum Soo Kim
Background Since oligodendroglial tumors are sensitive to chemotherapy and have a better prognosis, the differentiation of oligodendroglial tumors (OT) from astrocytic tumors (AT) is important. Purpose To investigate the perfusion and permeability parameters that differentiate grade II and III OT from AT, using dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI). Material and Methods We retrospectively reviewed the DCE and DSC MRIs of 39 patients with OT (OTs, n = 19; grade II, n = 12 and grade III, n = 7) and AT (ATs, n = 20; grade II, n = 7 and grade III, n = 13)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28851427/the-frequency-and-prognostic-effect-of-tert-promoter-mutation-in-diffuse-gliomas
#11
Yujin Lee, Jaemoon Koh, Seong-Ik Kim, Jae Kyung Won, Chul-Kee Park, Seung Hong Choi, Sung-Hye Park
Mutations in the telomerase reverse transcriptase gene promoter (TERTp) are common in glioblastomas (GBMs) and oligodendrogliomas (ODGs), and therefore, have a key role in tumorigenesis and may be of prognostic value. However, the extent of their prognostic importance in various gliomas is controversial. We studied 168 patients separated into five groups: Group 1: 65 patients with ODG carrying an IDH1 or IDH2 mutation (IDH-mutant) and 1p/19q-codeletion, Group 2: 23 patients with anaplastic astrocytoma (AA), IDH-mutant, Group 3: 13 patients with GBM, IDH-mutant, Group 4: 15 patients with AA, IDH-wildtype (WT), and Group 5: 52 patients with GBM, IDH-WT...
August 29, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28845038/treatment-recommendations-for-adult-patients-with-diffuse-gliomas-of-grades-ii-and-iii-according-to-the-new-who-classification-in-2016
#12
Hikaru Sasaki, Kazunari Yoshida
With advanced understanding of molecular background and correlation with therapeutic outcomes, the revised 4th edition of World Health Organization (WHO) classification of central nervous system (CNS) tumors incorporated molecular information into the definition of diffuse gliomas. Indeed, oligodendroglioma and astrocytoma are now defined by molecular signature, with diagnosis of glioblastoma being made by histology. In parallel, numerous clinical trials are underway all over the world, and important findings are being produced every year that have an impact on patient outcomes...
August 25, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28844925/case-study-multimodal-18-f-fluciclovine-pet-mri-and-ultrasound-guided-neurosurgery-of-an-anaplastic-oligodendroglioma
#13
Anna Karlberg, Erik Magnus Berntsen, Håkon Johansen, Mariane Myrthue, Anne Jarstein Skjulsvik, Ingerid Reinertsen, Morteza Esmaeili, Hong Yan Dai, Yiming Xiao, Hassan Rivaz, Per Borghammer, Ole Solheim, Live Eikenes
BACKGROUND: Structural MRI and histopathological tissue sampling are routinely performed as part of the diagnostic work-up of glioma patients. Due to the heterogeneous nature of gliomas, there is however a risk of undergrading caused by histopathological sampling errors. MRI has limitations in identifying tumor grade and type, detecting diffuse invasive growth, and separating recurrences from treatment induced changes. PET can provide quantitative information of cellular activity and metabolism, and may therefore complement MRI...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28836232/diencephalic-pediatric-low-grade-glioma-harboring-the-braf-v600e-mutation-presenting-with-various-morphologies-in-sequential-biopsy-specimens
#14
Yukitomo Ishi, Kanako C Hatanaka, Shigeru Yamaguchi, Hiromi Fujita, Hiroaki Motegi, Hiroyuki Kobayashi, Shunsuke Terasaka, Kiyohiro Houkin
A 5-year-old boy underwent biopsy of an intra-axial calcified tumor in the hypothalamus, which was incidentally found. Based on the presence of ganglion-like cells combined with glial cell element, the pathological diagnosis was ganglioglioma. Because the tumor grew gradually in size over the next 2 years, he underwent chemotherapy with temozolomide. However, at 8 years of age, the boy developed hydrocephalus and the cystic lesion had re-grown. Endoscopic cyst fenestration and tumor biopsy was performed, and pathological diagnosis was tentatively oligodendroglioma based on the presence of tumor cells with a perinuclear halo...
August 23, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28815096/a-case-of-congenital-brainstem-oligodendroglioma-pathology-findings-and-review-of-the-literature
#15
Stefan Kostadinov, Suzanne de la Monte
Congenital and perinatal primary brain neoplasms are extremely rare. Brainstem neoplasms in the perinatal and neonatal period are typically of high-grade nature and have poor prognoses with survival rates of less than 2 years from diagnosis. Herein, we report an unusual case of congenital anaplastic oligodendroglioma that arose in the pons and was detected as diffuse pontine glioma on in utero imaging studies during prenatal evaluation at 26 weeks' gestation. A male infant was delivered at 36.4 weeks of gestation via Cesarean section who developed progressive dyspnea shortly after birth...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28812310/gliosarcoma-arising-from-oligodendroglioma-idh-mutant-and-1p-19q-codeleted
#16
Takayuki Yasuda, Masayuki Nitta, Takashi Komori, Tatsuya Kobayashi, Kenta Masui, Takashi Maruyama, Tatsuo Sawada, Yoshihiro Muragaki, Takakazu Kawamata
Herein, we present a rare case of gliosarcoma arising from oligodendroglioma, isocitrate dehydrogenase (IDH) mutant and 1p/19q codeleted. A 36-year-old man presented with a non-enhanced calcified abnormal lesion on the right frontal lobe. The patient underwent subtotal surgical resection, PAV chemotherapy (procarbazine, nimustine (ACNU) and vincristine), and fractionated radiotherapy with 50 Gy. The pathological diagnosis was oligodendroglioma, IDH mutant and 1p/19q codeleted, World Health Organization 2016 grade II...
August 15, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28803175/seeding-of-abdomen-with-primary-intracranial-hemangiopericytoma-by-a-ventriculoperitoneal-shunt-case-report
#17
Kelly Bridges, Rebecca Sauerwein, Marjorie Grafe, Vassiliki Liana Tsikitis, Aaron Halfpenny, Ahmed Raslan
BACKGROUND: Ventriculoperitoneal shunt (VPS) placement has been implicated in extraneural metastasis of many primary central nervous system tumors. Reported cases include, but are not limited to, medulloblastoma, germ cell tumor, astrocytoma, oligodendroglioma, lymphoma, ependymoma, melanoma, and choroid plexus tumors. However, a literature review reveals no reported cases of extraneural metastasis of solitary fibrous tumor/hemangiopericytoma (SFT/HPC). CASE DESCRIPTION: Here we report the case of a 34-year-old man with recurrent intracranial malignant SFT/HPC who had undergone surgical tumor resection and subsequent placement of a VPS for obstructive hydrocephalus in 2004...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28801347/a-simple-algorithmic-approach-using-histology-and-immunohistochemistry-for-the-current-classification-of-adult-diffuse-glioma-in-a-resource-limited-set-up
#18
R T Rajeswarie, Shilpa Rao, Bevinahalli N Nandeesh, T Chickabasaviah Yasha, Vani Santosh
AIMS: The WHO 2016 classification of diffuse gliomas combines histological and molecular parameters for diagnosis. However, in view of cost constraints for molecular testing, an economical working formula is essential to reach a meaningful diagnosis in a resource-limited setting. The aim of this study was to establish a practical algorithmic approach using histology and immunohistochemistry (IHC) in the classification of diffuse gliomas in such a set-up. METHODS: Diffuse gliomas of WHO grade II and III diagnosed in our institute in the year 2016 were analysed for histological and IHC features, using the markers isocitrate dehydrogenase 1 (IDH1R132H) and α thalassemia/mental retardation syndrome X-linked gene (ATRX)...
August 11, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28797937/immunohistochemical-characterization-and-sensitivity-to-human-adenovirus-serotypes-3-5-and-11p-of-new-cell-lines-derived-from-human-diffuse-grade-ii-to-iv-gliomas
#19
Minna Niittykoski, Mikael von Und Zu Fraunberg, Miika Martikainen, Tuomas Rauramaa, Arto Immonen, Susanna Koponen, Ville Leinonen, Markus Vähä-Koskela, Qiwei Zhang, Florian Kühnel, Ya-Fang Mei, Seppo Ylä-Herttuala, Juha E Jääskeläinen, Ari Hinkkanen
BACKGROUND: Oncolytic adenoviruses show promise in targeting gliomas because they do not replicate in normal brain cells. However, clinical responses occur only in a subset of patients. One explanation could be the heterogenic expression level of virus receptors. Another contributing factor could be variable activity of tumor antiviral defenses in different glioma subtypes. METHODS: We established a collection of primary low-passage cell lines from different glioma subtypes (3 glioblastomas, 3 oligoastrocytomas, and 2 oligodendrogliomas) and assessed them for receptor expression and sensitivity to human adenovirus (HAd) serotypes 3, 5, and 11p...
August 3, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28796376/neuropsychiatric-adverse-events-of-antiepileptic-drugs-in-brain-tumour-related-epilepsy-an-italian-multicentre-prospective-observational-study
#20
C Bedetti, M Romoli, M Maschio, C Di Bonaventura, E Nardi Cesarini, P Eusebi, S Siliquini, S Dispenza, P Calabresi, C Costa
BACKGROUND AND PURPOSE: We assessed the prevalence and magnitude of neuropsychiatric adverse events (NPAEs) associated with antiepileptic drugs (AEDs) among patients with brain tumour-related epilepsy (BTRE). METHODS: This observational, prospective, multicentre study enrolled 259 patients with BTRE after neurosurgery. All patients received AED monotherapy. Efficacy was assessed through clinical diaries, whereas NPAEs were collected using the Neuropsychiatric Inventory Test-12 questionnaire at baseline and after 5 months...
August 10, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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