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https://www.readbyqxmd.com/read/28093610/the-new-who-2016-classification-of-brain-tumors-what-neurosurgeons-need-to-know
#1
REVIEW
Rouzbeh Banan, Christian Hartmann
BACKGROUND: The understanding of molecular alterations of tumors has severely changed the concept of classification in all fields of pathology. The availability of high-throughput technologies such as next-generation sequencing allows for a much more precise definition of tumor entities. Also in the field of brain tumors a dramatic increase of knowledge has occurred over the last years partially calling into question the purely morphologically based concepts that were used as exclusive defining criteria in the WHO 2007 classification...
January 17, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28074710/canine-spinal-cord-glioma
#2
Daniel R Rissi, Renee Barber, Annabelle Burnum, Andrew D Miller
Spinal cord glioma is uncommonly reported in dogs. We describe the clinicopathologic and diagnostic features of 7 cases of canine spinal cord glioma and briefly review the veterinary literature on this topic. The median age at presentation was 7.2 y. Six females and 1 male were affected and 4 dogs were brachycephalic. The clinical course lasted from 3 d to 12 wk, and clinical signs were progressive and associated with multiple suspected neuroanatomic locations in the spinal cord. Magnetic resonance imaging of 6 cases revealed T2-weighted hyperintense lesions with variable contrast enhancement in the spinal cord...
January 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28064387/the-role-of-histone-modifications-and-telomere-alterations-in-the-pathogenesis-of-diffuse-gliomas-in-adults-and-children
#3
REVIEW
Julieann Lee, D A Solomon, Tarik Tihan
Genetic profiling is an increasingly useful tool for sub-classification of gliomas in adults and children. Specific gene mutations, structural rearrangements, DNA methylation patterns, and gene expression profiles are now recognized to define molecular subgroups of gliomas that arise in distinct anatomic locations and patient age groups, and also provide a better prediction of clinical outcomes for glioma patients compared to histologic assessment alone. Understanding the role of these distinctive genetic alterations in gliomagenesis is also important for the development of potential targeted therapeutic interventions...
January 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28060678/canine-central-nervous-system-neoplasm-phenotyping-using-tissue-microarray-technique
#4
I Spitzbarth, F Heinrich, V Herder, T Recker, P Wohlsein, W Baumgärtner
Tissue microarrays (TMAs) represent a useful technique for the simultaneous phenotyping of large sample numbers and are particularly suitable for histopathologic tumor research. In this study, TMAs were used to evaluate semiquantitatively the expression of multiple antigens in various canine central nervous system (CNS) neoplasms and to identify markers with potential discriminative diagnostic relevance. Ninety-seven canine CNS neoplasms, previously diagnosed on hematoxylin and eosin sections according to the World Health Organization classification, were investigated on TMAs, with each tumor consisting of 2 cylindrical samples from the center and the periphery of the neoplasm...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28042970/targeted-next-generation-sequencing-in-molecular-subtyping-of-lower-grade-diffuse-gliomas-application-of-the-world-health-organization-s-2016-revised-criteria-for-cns-tumors
#5
Jamal H Carter, Samantha N McNulty, Patrick J Cimino, Catherine E Cottrell, Jonathan W Heusel, Katinka A Vigh-Conrad, Eric J Duncavage
The 2007 World Health Organization Classification of Tumours of the Central Nervous System classifies lower-grade gliomas [LGGs (grades II to III diffuse gliomas)] morphologically as astrocytomas or oligodendrogliomas, and tumors with unclear ambiguous morphology as oligoastrocytomas. The World Health Organization's newly released (2016) classification incorporates molecular data. A single, targeted next-generation sequencing (NGS) panel was used for detecting single-nucleotide variation and copy number variation in 50 LGG cases originally classified using the 2007 criteria, including 36 oligoastrocytomas, 11 oligodendrogliomas, 2 astrocytomas, and 1 LGG not otherwise specified...
December 30, 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28040713/the-impact-of-body-mass-index-and-height-on-the-risk-for-glioblastoma-and-other-glioma-subgroups-a-large-prospective-cohort-study
#6
Markus K H Wiedmann, Cathrine Brunborg, Antonio Di Ieva, Kristina Lindemann, Tom B Johannesen, Lars Vatten, Eirik Helseth, John A Zwart
BACKGROUND: Glioma comprises a heterogeneous group of mostly malignant brain tumors, whereof glioblastoma (GBM) represents the largest and most lethal subgroup. Body height and body mass index (BMI) are risk factors for other cancers, but no previous study has examined anthropometric data in relation to different glioma subgroups. METHODS: This prospective cohort study includes 1.8 million Norwegian women and men between ages 14 and 80 years at baseline. Body weight and height were measured, and incident cases of glioma were identified by linkage to the National Cancer Registry...
December 31, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28038915/preoperative-grading-of-supratentorial-gliomas-using-high-or-standard-b-value-diffusion-weighted-mr-imaging-at-3t
#7
M M Cihangiroglu, E Ozturk-Isik, Z Firat, O Kilickesmez, A M Ulug, U Ture
PURPOSE: The goal of this study was to compare diffusion-weighted magnetic resonance imaging (DW-MRI) using high b-value (b=3000s/mm(2)) to DW-MRI using standard b-value (b=1000s/mm(2)) in the preoperative grading of supratentorial gliomas. MATERIALS AND METHODS: Fifty-three patients with glioma had brain DW-MRI at 3T using two different b-values (b=1000s/mm(2) and b=3000s/mm(2)). There were 35 men and 18 women with a mean age of 40.5±17.1 years (range: 18-79 years)...
December 27, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28030632/contribution-of-1p-19q-9p-and-10q-automated-analysis-by-fish-to-the-diagnosis-and-prognosis-of-oligodendroglial-tumors-according-to-who-2016-guidelines
#8
Karine Michaud, Marie de Tayrac, Myreille D'Astous, Céline Duval, Claudie Paquet, Oumar Samassekou, Peter Vincent Gould, Stéphan Saikali
OBJECTIVE: To study the feasibility and the diagnostic and prognostic interest of automated analysis of 1p, 19q, 9p and 10q status by FISH technique in oligodendroglial tumors. METHODS: We analyzed a retrospective series of 33 consecutive gliomas with oligodendroglial histology (originally diagnosed as 24 oligodendrogliomas and 9 oligoastrocytomas). For all cases, automated FISH analysis of 1p, 19q, 9p and 10q status were performed and compared to clinical and histological data, ATRX, IDH1R132H and alpha-internexin status (studied by immunohistochemistry) and overall survival (OS)...
2016: PloS One
https://www.readbyqxmd.com/read/28029275/oligodendroglial-cell-proliferation-arising-in-an-ovarian-mature-cystic-teratoma-clinicopathological-inmunohistochemical-and-ultrastructural-study-of-a-case-that-may-represent-an-oligodendroglioma
#9
Mónica Lizzette Serrano-Arévalo, Leonardo Saúl Lino-Silva, Hugo Ricardo Domínguez Malagón
Ovarian mature cystic teratoma (OMCT) is an ovarian benign neoplasm with excellent prognosis presenting components of the three germinal layers. However, transformation into a malignant neoplasm is a rare event (so-called somatic transformation). In most of the cases, the malignant component expresses as epidermoid carcinoma, but occasionally central nervous system tumors occur. Some of the previously reported tumors are astrocytoma, glioblastoma, and ependymoma. Somatic transformation of OMCT into an oligodendroglioma is exceptional...
December 28, 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28024733/racial-disparities-in-anaplastic-oligodendroglioma-an-analysis-on-1643-patients
#10
Jacob Y Shin, Ja Kyoung Yoon, Aidnag Z Diaz
The objective of our study is to determine the influence of race on overall survival (OS) for anaplastic oligodendroglioma (AO). Data were extracted from the National Cancer Data Base (NCDB). Chi-square test, Kaplan-Meier method, and Cox regression models were employed in SPSS 22.0 (Armonk, NY: IBM Corp.) for data analyses. 1643 patients with AO were identified. 1386 (84.3%) were White, 83 (5.0%) Black, 133 (8.1%) Hispanic, and 41 (2.5%) were Asian. White and Black patients were significantly older than Hispanic and Asian patients (49...
December 23, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28017579/seizures-caused-by-brain-tumors-in-children
#11
Iván Sánchez Fernández, Tobias Loddenkemper
PURPOSE: To review the epidemiology, clinical features, and treatment of seizures secondary to pediatric brain tumors. METHOD: Literature review. RESULTS: Pediatric brain tumors are the most common solid pediatric tumor and the most common cause of death in pediatric cancer. Seizures are one of the most common symptoms of pediatric brain tumors. Factors associated with increased risk of seizures include supratentorial location, gray matter involvement, low-grade, and certain histological features-especially dysembryoplastic neuroepithelial tumor, ganglioglioma, and oligodendroglioma...
December 7, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28007636/inflammatory-landscape-of-human-brain-tumors-reveals-an-nf%C3%AE%C2%BAb-dependent-cytokine-pathway-associated-with-mesenchymal-glioblastoma
#12
Alfeu Zanotto-Filho, Rosângela Mayer Gonçalves, Karina Klafke, Priscila Oliveira de Souza, Fabiane Cristine Dillenburg, Luigi Carro, Daniel Pens Gelain, José Cláudio Fonseca Moreira
The tumor microenvironment is being increasingly recognized as a key factor in cancer aggressiveness. In this study, we characterized the inflammatory gene signatures altered in glioma cell lines and tumor specimens of differing histological and molecular subtypes. The results showed that glioblastoma multiforme (GBM) shows upregulation of a subset of inflammatory genes when compared to astrocytomas and oligodendrogliomas. With molecular subtypes of GBM, the expression of inflammatory genes is heterogeneous, being enriched in mesenchymal and downregulated in Proneural and GCIMP...
December 20, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27995658/microvascular-proliferation-of-brain-metastases-mimics-glioblastomas-in-squash-cytology
#13
T Gi, Y Sato, T Tokumitsu, A Yamashita, S Moriguchi-Goto, H Takeshima, S Sato, Y Asada
OBJECTIVE: Although microvascular proliferation is a key feature in the diagnosis of high-grade glioma, the characteristics of metastatic tumour vessels in smear preparations have not been documented. In this study, the vascular changes in metastatic brain tumours, using squash cytology to examine the vascular patterns in brain metastases, were reviewed. METHODS: One hundred and forty-three squash smears of brain tissue, including 25 normal or reactive tissue, 23 malignant lymphomas, 8 grade I glioma (pilocytic astrocytoma), 23 grade II glioma (diffuse astrocytoma and oligodendroglioma), 42 grade IV glioma (glioblastoma), and 22 metastasis, were assessed...
December 19, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27943684/treatment-strategies-for-low-grade-glioma-in-adults
#14
Nancy Ann Oberheim Bush, Susan Chang
Diffuse low-grade gliomas include oligodendrogliomas and astrocytomas. The recent 2016 WHO classification has now updated the definition of these tumors to include molecular characterization, including the presence of isocitrate dehydrogenase mutation and 1p/19q codeletion. In this new classification, the histologic subtype of grade II mixed oligoastrocytoma has been eliminated. Treatment recommendations are currently evolving, mainly because of a change in the prognostic factors that are based on molecular and cytogenetic features...
December 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27903792/clinical-effectiveness-of-bevacizumab-in-patients-with-recurrent-brain-tumours-a-population-based-evaluation
#15
REVIEW
Mário L de Lemos, Adeline Markarian, Esther Chan, Kimberly Schaff, Susan Walisser
BACKGROUND: Bevacizumab is an antiangiogenic agent active in patients with recurrent malignant gliomas. However, evidence for its clinical efficacy is relatively limited so that bevacizumab is approved for this indication in Canada and the United States, but not in the European Union. We reviewed the effectiveness of bevacizumab in patients with recurrent brain tumour using a large population database. METHODS: This was a retrospective, multicentre, study conducted at the BC Cancer Agency, a public cancer care organisation for the residents of the Canadian province of British Columbia...
November 30, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27900202/radiological-imaging-features-of-glioblastoma-with-oligodendroglioma-component-a-comparison-with-conventional-glioblastoma
#16
Masafumi Kanoto, Kazukuni Kirii, Yuuki Toyoguchi, Masashi Nishihara, Keita Sakurai, Kazuhiro Murayama, Tomoyuki Noguchi, Kenichiro Matsuda, Kaori Sakurada, Yukihiko Sonoda, Takaaki Hosoya
BACKGROUND: Glioblastoma with oligodendroglioma component (GBMO) is a subtype of conventional glioblastoma (cGBM), which is categorized as WHO grade IV. GBMO can be histopathologically distinguished from cGBM and the prognosis of GBMO is better than that of cGBM. However, no systematic review of GBMO imaging findings has been published to date. PURPOSE: To clarify the radiological imaging features of GBMO compared with those of cGBM. MATERIAL AND METHODS: The participants were 15 patients with GBMO and 32 patients with cGBM as a control group, all of whom were histopathologically diagnosed...
November 2016: Acta Radiologica Open
https://www.readbyqxmd.com/read/27895504/deferred-radiotherapy-and-upfront-procarbazine-acnu-vincristine-administration-for-1p19q-codeleted-oligodendroglial-tumors-are-associated-with-favorable-outcome-without-compromising-patient-performance-regardless-of-who-grade
#17
Nobuhiro Hata, Koji Yoshimoto, Ryusuke Hatae, Daisuke Kuga, Yojiro Akagi, Satoshi O Suzuki, Toru Iwaki, Tadahisa Shono, Masahiro Mizoguchi, Koji Iihara
Recently updated phase III trials revealed the favorable effect of add-on procarbazine-lomustine-vincristine chemotherapy (CT) to radiotherapy (RT) in treating anaplastic oligodendrogliomas with 1p19q codeletion (codel). However, the underlying rationality of deferring RT and upfront CT administration for these tumors is yet to be elucidated. Here, we retrospectively analyzed the long-term outcome of our case series with oligodendroglial tumors treated with deferred RT and upfront procarbazine+nimustine+vincristine (PAV) in the introduction administration...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27895359/awake-craniotomy-for-brain-tumours-in-pakistan-an-initial-case-series-from-a-developing-country
#18
Saad Akhtar Khan, Karim Rizwan Nathani, Badar Uddin Ujjan, Muhammad Danish Barakzai, Syed Ather Enam, Faraz Shafiq
Awake craniotomy offers safe resection of brain tumours in eloquent area. Aga Khan University Hospital, Karachi, recently started the programme in Pakistan, and the current study was planned to assess our experience of the first 16 procedures. The retrospective study comprised all such procedures done from November 2015 to May 2016. Pre-operative and post-operative variables were analysed. Of the 16 patients, 11(68.75%) were males and 5(31.25%) were females. The overall median age was 37 years (interquartile range[IQR]: 23-62 years)...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27893285/recent-advances-in-subtyping-tumors-of-the-central-nervous-system-using-molecular-data
#19
Jens Schittenhelm
Primary brain tumors account for substantial morbidity and mortality. They often infiltrate the brain diffusely, continue growing, and cause adverse events, such as headaches, seizures, and neurological deficits. The classification of primary brain tumors, based for decades on histology, has been fundamentally changed by the World Health Organization in 2016 by incorporation of molecular data. Areas covered: Literature from glioblastomas, high- and low-grade astrocytic, oligodendroglial, glioneuronal and ependymal tumors from the last five years were reviewed...
January 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27874063/cns-cancer-tracing-stem-cells-in-oligodendroglioma
#20
Diana Romero
No abstract text is available yet for this article.
January 2017: Nature Reviews. Clinical Oncology
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