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https://www.readbyqxmd.com/read/29908379/simultaneous-supratentorial-and-infratentorial-pilocytic-astrocytoma-in-an-adult-patient-with-concurrent-neurofibromatosis-type-1-and-hiv-infection
#1
Dalila Forte, Anabela Nabais, Carlos Pontinha, Manuela Mafra, Luís Mateus
BACKGROUND: Neurofibromatosis type 1 (NF1) is a tumour predisposing condition, being Pilocytic Astrocytomas (PA) a common benign central nervous system (CNS) tumour occurring in this setting. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in non-optic or hypothalamic locations. CLINICAL CASE: A 41 year-old female patient with neurofibromatosis type 1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presents with a first generalized seizure and associated headache and ataxia...
June 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29908349/mr-diffusion-kurtosis-imaging-for-cancer-diagnosis-a-meta-analysis-of-the-diagnostic-accuracy-of-quantitative-kurtosis-value-and-diffusion-coefficient
#2
Lu Shen, Guoxing Zhou, Fei Tang, Yi Lin, Jie Zhou, Pinshuo Lv, Yibin Wang, Genlin Zong, Jiangmin Zhao
PURPOSE: To perform a meta-analysis for assessing the accuracy of diffusion kurtosis imaging (DKI)-derived quantitative parameters (kurtosis values, K; and corrected diffusion coefficients non-Gaussian bias, D) in separating malignant cancers from benign lesions. METHODS: Relevant studies were searched in PubMed and Cochrane Library databases and were analyzed by Meta-DiSc software. RESULTS: Fourteen eligible studies involving 1847 lesions in 1107 patients (895 were benign and 952 were malignant) were included...
June 9, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29908340/ureterolysis-for-laparoscopic-hysterectomy
#3
Haider Jan, Vishalli Ghai
STUDY OBJECTIVE: To demonstrate techniques of ureterolysis during complex laparoscopic hysterectomy. DESIGN: Technical video demonstrating different approaches to ureterolysis for complex benign pathology during laparoscopic hysterectomy. (Canadian Task force classification level III) SETTING: Benign gynaecology department at a University Hospital. INTERVENTION: We perform ureterolysis during laparoscopic hysterectomy for benign pathology...
June 13, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29908103/prevalence-of-human-respiratory-syncytial-virus-infection-in-people-with-acute-respiratory-tract-infections-in-africa-a-systematic-review-and-meta-analysis
#4
Sebastien Kenmoe, Jean Joel Bigna, Estelle Amandine Well, Fredy Brice N Simo, Véronique B Penlap, Astrid Vabret, Richard Njouom
AIM: The epidemiology of Human Respiratory Syncytial virus (HRSV) infection has not yet been systematically investigated in Africa. This systematic review and meta-analysis is to estimate the prevalence of HRSV infections in people with acute respiratory tract infections (ARTI) in Africa. METHOD: We searched PubMed, EMBASE, Africa Journal Online, and Global Index Medicus to identify observational studies published from Jan 1, 2000 to Aug 1, 2017. We used a random-effects model to estimate the prevalence across studies...
June 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29908099/pathogenesis-of-primordial-odontogenic-tumour-based-on-tumourigenesis-and-odontogenesis
#5
Toshinari Mikami, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Ikuko Ogawa, Vanesa Pereira-Prado, Naoki Fujiwara, Fabio Ramoa Pires, Roman Carlos, Takashi Takata, Yasunori Takeda
OBJECTIVE: Primordial odontogenic tumour (POT) is a rare benign mixed epithelial and mesenchymal odontogenic tumour. POT is composed of dental papilla-like tissue covered with cuboidal to columnar epithelium that resembles to inner and outer enamel epithelium of the enamel organ without dental hard tissue formation. The aim of this study was to examine pathogenesis of POT based on tumourigenesis and odontogenesis. SUBJECTS AND METHODS: Six cases of POT were submitted for study...
June 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29907895/feasibility-of-analysis-of-the-scn5a-gene-in-paraffin-embedded-samples-in-sudden-infant-death-cases-at-the-pretoria-medico-legal-laboratory-south-africa
#6
Barbara Ströh van Deventer, Lorraine du Toit-Prinsloo, Chantal van Niekerk
To determine variations in the SCN5A gene linked to inherited cardiac arrhythmogenic disorders in sudden, unexplained infant death (SUID) cases examined at the Pretoria Medico-Legal Laboratory, South Africa. A retrospective study was conducted on SUID cases and controls, analyzing DNA extracted from archived formalin-fixed, paraffin-embedded (FFPE) myocardial tissue samples as well as blood samples. A total of 48 FFPE tissue samples (cases), 10 control FFPE tissue samples and nine control blood samples were included...
June 16, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29907593/the-role-of-pyruvate-dehydrogenase-kinase-4-pdk4-in-bladder-cancer-and-chemoresistance
#7
Benjamin L Woolbright, Dharamainder Choudhary, Andrew Mikhalyuk, Cassandra Trammel, Sambantham Shanmugam, Erika Abbott, Carol C Pilbeam, John A Taylor
Advanced bladder cancer (BCa) remains a major source of mortality, with poor treatment options. Cisplatin based chemotherapy is the standard treatment, however many patients are or become resistant. One potential cause of chemoresistance is the Warburg Effect, a metabolic switch to aerobic glycolysis that occurs in many cancers. Upregulation of the pyruvate dehydrogenase kinase family (PDK1-4) is associated with aerobic glycolysis and chemoresistance through inhibition of the pyruvate dehydrogenase complex (PDH)...
June 15, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29907496/-where-do-we-stand-with-benign-prostatic-hyperplasia-day-case-surgery-a-laser-effect
#8
L Gury, G Robert, H Bensadoun
INTRODUCTION AND OBJECTIVES: Despite its feasibility has been proven, Benign Prostatic Hyperplasia (BPH) day-case surgery remains uncommon. Our objective was to describe the evolution of BPH day-case surgery in France according to the surgical technique employed. MATERIALS AND METHODS: We extracted data from the Information System of Medicalization Program (PMSI) including all of the hospital stays in France from 2010 to 2016. Patients belonging to the transurethral prostatectomy homogeneous group of patients (GHM 12C04) and having as a main diagnosis prostatic hyperplasia (N40) or benign prostatic tumor (D291) were included in the analysis...
June 12, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29907266/mri-features-of-clinical-outcome-in-bipolar-disorder-a-selected-review
#9
REVIEW
N Dusi, V De Carlo, G Delvecchio, M Bellani, J C Soares, P Brambilla
BACKGROUND: Bipolar disorder (BD) is a severe and disabling mental illness, which is characterized by selective gray matter (GM) and white matter (WM) brain alterations, as observed by several imaging studies. However, the clinical course of the disease is uncertain and can vary across BD patients, with some having a benign course and others a severe disability. In this perspective, magnetic resonance imaging (MRI) can help identifying biological markers of worse prognosis. METHODS: The present selected review aimed at summarizing structural MRI (sMRI) studies exploring the correlation between brain morphology and features of clinical outcome, which could include treatment response, cognitive impairment and global functioning...
June 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29907243/the-risk-of-stroke-after-bilateral-salpingo-oophorectomy-at-hysterectomy-for-benign-diseases-a-nationwide-cohort-study
#10
Jerry Cheng-Yen Lai, Yiing-Jenq Chou, Nicole Huang, Hung-Hui Chen, Kung-Liahng Wang, Chien-Wei Wang, I-Hsuan Shen, Hung-Chang Chang
OBJECTIVE: To assess the risk of stroke (and subtypes of stroke) in women after elective bilateral salpingo-oophorectomy at hysterectomy for benign diseases. STUDY DESIGN: We conducted a nationwide population-based, retrospective cohort study using claims data from Taiwan's National Health Insurance program between 1997 and 2013. Women aged 20 years or more who underwent bilateral salpingo-oophorectomy at hysterectomy for benign diseases (n = 1083) were compared with women who did not undergo bilateral salpingo-oophorectomy at hysterectomy for benign diseases (n = 3903)...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907218/pediatric-breast-masses-an-argument-for-observation
#11
Cory M McLaughlin, Jessica Gonzalez-Hernandez, Monica Bennett, Hannah G Piper
BACKGROUND: Pediatric breast masses can be a diagnostic challenge. Nearly all are benign, but there is no consensus on which should be removed. We hypothesized that children with asymptomatic breast lesions can be safely managed nonoperatively. METHODS: We performed a single-institution retrospective review of children (≤18 y) who underwent breast mass excision from 2008 to 2016. Male patients with gynecomastia and those who had needle biopsy without formal excision were excluded...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907208/well-differentiated-thyroid-cancer-and-robotic-transaxillary-surgery-at-a-north-american-institution
#12
Meghan Garstka, Khuzema Mohsin, Daniah Bu Ali, Hosam Shalaby, Kareem Ibraheem, Mahmoud Farag, Sang-Wook Kang, Emad Kandil
BACKGROUND: Recent studies from Asia have reported the safety and feasibility of robotic-assisted thyroid surgery. In the United States, several small series and case reports have been published, mostly regarding treatment of benign disease. The aim of our study is to report the safety and feasibility of robotic surgery for well-differentiated thyroid cancer patients at a North American institution. MATERIALS AND METHODS: We performed a retrospective cohort study using a prospectively collected single-center clinical database at Tulane University Medical Center...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906740/diagnostic-challenges-in-clinical-radiological-and-histopathological-tests-regarding-papillomatous-lesions-of-the-breast
#13
Birgitte Bruun Rasmussen, Eva Balslev, Ib Jarle Christensen, Charlotte Lanng, Anne Bak, Hanne Galatius, Maj-Lis Møller Talman, Nahid Sharghi Someh, Ilse Vejborg, Mette Okholm
Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation...
May 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29906625/computed-tomography-and-magnetic-resonance-imaging-findings-of-pancreatic-hamartoma-a-case-report-and-literature-review
#14
Yeo Eun Han, Beom Jin Park, Deuk Jae Sung, Min Ju Kim, Na Yeon Han, Ki Choon Sim, Sung Bum Cho, Joo Young Kim
Pancreatic hamartoma is a rare benign malformation that resembles a neoplasm and may be mistaken for a malignancy. The imaging findings of pancreatic hamartoma are not well established, as only one radiological case report has been described since 1983. Herein, we discussed a case of pancreatic hamartoma in a 35-year-old woman and conducted a literature review focused on imaging findings and differential diagnosis of pancreatic hamartoma. Increased late enhancement on post-contrast dynamic study and absence of diffusion restriction may be characteristic MR imaging findings of pancreatic hamartoma that may narrow the differential diagnosis of hypervascular pancreatic lesions...
June 6, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29906523/ventricular-fibromas-in-children-arrhythmia-risk-and-outcomes-a-multicentre-study
#15
John P Jones, Tristan Ramcharan, Milind Chaudhari, Vinay Bhole, Karen Mcleod, Shankar Sadagopan, Orhan Uzun, Andrew Parry, Jan Till, Colin J McMahon, Alan G Stuart, Mark A Walsh
BACKGROUND: Although ventricular fibromas are a rare, they are the second most common type of cardiac tumor in children. While histologically benign, they have a propensity to cause malignant arrhythmias, with cardiac arrest often being the first presentation.; OBJECTIVE: To evaluate the arrhythmia risk, and management strategies for pediatric ventricular fibromas. METHODS: Fifteen centers in the British Paediatric Arrhythmia Group network were contacted to partake in the study to contribute cases...
June 12, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29906480/the-use-of-5-alpha-reductase-inhibitors-to-manage-benign-prostatic-hyperplasia-and-the-risk-of-all-cause-mortality
#16
Lauren P Wallner, Julia R DiBello, Bonnie H Li, Stephen K Van Den Eeden, Sheila Weinmann, Debra P Ritzwoller, Jill E Abell, Ralph D'Agostino, Ronald K Loo, David S Aaronson, Ralph I Horwitz, Steven J Jacobsen
OBJECTIVE: To compare the risk of mortality among men treated for benign prostatic hyperplasia (BPH) with 5?-reductase inhibitors (5ARI) to those treated with alpha-blockers (AB) in community practice settings. METHODS: We employed a retrospective matched cohort study in 4 regions of an integrated healthcare system. Men ages 50 years and older who initiated pharmaceutical treatment for BPH/LUTS between 1992 and 2008 and had at least 3 consecutive prescriptions were eligible and followed through 2010 (N=174,895)...
June 12, 2018: Urology
https://www.readbyqxmd.com/read/29906309/evolution-of-pigmented-spitz-nevi-with-starburst-pattern-during-childhood
#17
G Brancaccio, B Brunetti, E Fulgione, E Moscarella, R Alfano, G Argenziano
Spitz nevi (SN) are benign melanocytic lesions typical of childhood/adolescence that can mimic melanoma on a clinical, dermoscopic, and histopathologic level. Moreover, SN are often characterized by rapid growth and worrisome changes. Thus, their diagnosis and management may be challenging. The knowledge on prognosis and natural history of SN improved substantially in the last few years thanks to dermoscopy and a better understanding of clinic-pathologic correlations. This article is protected by copyright...
June 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29906036/parapharyngeal-space-lipoma-resection-under-transmandibular-approach
#18
Juan Guillermo Sánchez-Acuña, Laura Elena Franco-Garrocho, Omar Esteban Durán-Macías, Aarón Peralta-Mata
Lipoma is a benign entity with a poor incidence in craniofacial region. The most frequent tumors in the maxillo pharyngeal space are those that occur in the major and minor salivary glands, with a higher incidence of pleomorphic adenoma, also consider a benign entity. The transmandibular approach offers a great advantage in terms of visibility during the surgery. Achieving a lower morbidity, due to the fact that anatomic structures of anterior (prestyloid) and posterior (retrostyloid) compartments are involved...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29906007/myopericytoma-in-an-unusual-location
#19
Leon Felipe Ruiz-Arriaga, Ana Laura Ramirez Teran, Carlos Ortiz-Hidalgo, Veronica Fonte-Avalos, Sonia Toussaint-Caire, Ma Elisa Vega-Memije, Mariana CatalinaDe Anda-Juarez
Myopericytoma is a soft-tissue tumor of perivascular cells (pericytes). It is slow-growing, usually asymptomatic, and generally benign, although a malignant variant has been described. The etiology is unknown, but it has been associated with local trauma. The most common location is on the distal extremities. Histologically, it is characterized by a well-circumscribed, non-encapsulated proliferation of spindle shaped cells similar to myofibroblasts with oval nuclei and eosinophilic cytoplasm, arranged in perivascular concentric rings...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29905601/huge-bursitis-and-bursal-synovial-osteochondromatosis-associated-with-scapular-osteochondroma-mimicking-a-giant-calcific-mass-of-the-chest-wall-a-case-report
#20
Kutsi Tuncer, Emine Izgi, Bahar Cankaya, Hayri Ogul, Mecit Kantarci
Osteochondroma is the most common benign bone tumor but it rarely arises from the scapula. Scapulothoracic bursitis is quite rare and osteochondroma is one of the unusual causes of this condition. Synovial chondromatosis may occur extremely uncommonly in this bursa. We reported an unusual case of scapulothoracic bursitis with synovial chondromatosis which is caused by osteochondroma. To the best of our knowledge, there is no defined chondromatosis in the scapulothoracic bursa secondary to scapular osteochondroma in the literature...
June 13, 2018: American Journal of Physical Medicine & Rehabilitation
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