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https://www.readbyqxmd.com/read/28343327/osteolytic-variant-poems-syndrome-an-uncommon-presentation-of-osteosclerotic-myeloma
#1
Michael S Clark, Benjamin M Howe, Katrina N Glazebrook, Michelle L Mauermann, Stephen M Broski
Polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome, a form of osteosclerotic myeloma, is a multisystem disease related to a monoclonal plasma cell proliferative disorder. Osseous lesions are most commonly sclerotic on radiographs and computed tomography (CT), demonstrate low T1 and T2 signal intensity on magnetic resonance imaging (MRI), and have variable degrees of avidity on positon emission tomography (PET) imaging using 18-fluorodeoxyglucose ((18)F-FDG). We present three cases of POEMS syndrome manifesting as osteolytic lesions with indolent features, including well-defined thin sclerotic rims, no cortical disruption or periosteal reaction, no associated soft-tissue mass, and a periarticular location, all features that could lead to misinterpretation as benign bone lesions...
March 25, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28343319/robotic-resection-of-an-obturator-schwannoma-with-preservation-of-normal-nerve-fascicles-and-function
#2
Hubert Perrin, Philippe Brunner, Jean Claude Ortega, Bertrand Mercier, Nathalie Clement, Christophe Robino, Maurice Chazal
An asymptomatic pelvic tumor was incidentally found in a 27-year-old man. A CT-guided needle biopsy with a pathologic examination confirmed the diagnosis of a benign schwannoma. We describe the complete robotic resection with the conservation of normal fascicles. The postoperative course was uneventful. No neurological deficit occurred, and the electromyogram was normal 6 weeks and 7 months later.
March 25, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28343231/segmental-testicular-infarction-case-series-and-literature-review-of-a-rare-diagnosis-in-men-with-acute-testicular-pain
#3
Simone Ernst, Matthias Saar, Horst Brenneis, Reinhard Kubale, Stefan Ueberdiek, Carsten-Henning Ohlmann, Michael Stoeckle, Julia Heinzelbecker
The incidence of segmental testicular infarction (STI) is very low. Such a disorder most often affects young men. The most common symptom is sudden testicular pain. We report 6 cases of men diagnosed with STI. Clinical examination, blood test, urine analysis, and ultrasound examination with colour Doppler were performed. Furthermore, tissue sonoelastography or MRI was performed in selected patients. All men underwent surgical exploration. In all but one man, the affected testis was preserved. Although STI is a rare condition, it should be taken into account if testicular pain prior to suspicious ultrasound imaging occurs...
March 24, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28343229/cytological-findings-of-ascitic-fluid-with-a-malignant-ovarian-steroid-cell-tumor-a-case-report-and-literature-review
#4
Nobuaki Kosaka, Kiyoshi Hasegawa, Kaori Kiuchi, Shoko Ochiai, Tamiko Nagai, Hiromi Machida, Yasuo Imai, Ichio Fukasawa
BACKGROUND: Ovarian steroid cell tumors (SCTs) are rare and usually benign, although 25-43% are reportedly malignant. The cytologic findings of these rare ovarian tumors have almost never been reported. CASE: We report a rare case of a malignant ovarian SCT with peritoneal dissemination and malignant ascites in a 40-year-old woman. Her tumor was classified as stage IIB (pT2bNoM0) according to the FIGO (International Federation of Gynecology and Obstetrics) classification system, and she was treated with adjuvant chemotherapy following staging laparotomy...
March 25, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28343220/hemorrhagic-transformations-after-thrombectomy-risk-factors-and-clinical-relevance
#5
Johannes Kaesmacher, Mirjam Kaesmacher, Christian Maegerlein, Claus Zimmer, Alexandra S Gersing, Silke Wunderlich, Benjamin Friedrich, Tobias Boeckh-Behrens, Justus F Kleine
BACKGROUND: Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke, potentially associated with clinical deterioration. We attempted to identify risk factors and evaluated clinical relevance of minor and major HTs following endovascular thrombectomy (ET) in isolated middle cerebral artery (MCA) occlusions. METHODS: This is a retrospective single-center analysis of 409 patients with isolated MCA occlusion treated with ET. Patients' and procedural characteristics, severity of HT according to the European Cooperative Acute Stroke Study criteria, and clinical outcomes were analyzed...
March 25, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28343178/fetal-cardiac-tumors-clinical-features-management-and-prognosis
#6
Shi-Min Yuan
Fetal cardiac tumors are rare and usually benign. While echocardiography is a reliable technique for diagnosing fetal cardiac tumors, their definitive diagnosis relies on pathological examination. The strategies used to manage fetal cardiac tumors are challenging. A good clinical result is their complete regression during pregnancy or shortly after birth, as often occurs with cardiac rhabdomyomas. Moreover, the fetal prognosis depends on the nature of the tumors, namely, their location, size, number and associated complications...
March 27, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28343174/mirna-analysis-in-pancreatic-cancer-the-dartmouth-experience
#7
Francine B de Abreu, Xiaoying Liu, Gregory J Tsongalis
Pancreatic cancer is considered one of the most lethal cancers being the fourth leading cause of cancer deaths in adults in the United States because of the lack of early signs and symptoms and the lack of early detection. Pancreatic ductal adenocarcinoma (PDAC) is the most common histological type among pancreatic cancers, representing 80%-90% of all solid tumors of the pancreas. The majority of PDAC develops from three precursor lesions: pancreatic intraepithelial neoplasia, intraductual papillary mucinous neoplasm and mucinous cystic neoplasm...
March 27, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28343002/pulmonary-metastatic-angiosarcoma-from-scalp-with-fatal-complication-a-case-report
#8
Yung-Sheng Cheng, Tim-Mo Chen, Wen-Chiuan Tsai, Tsai-Wang Huang
INTRODUCTION: Angiosarcoma is a rare malignant neoplasm with poor prognosis. Angiosarcoma of the scalp is frequently recurs locally, and metastasizes early despite various treatments. The common sites of metastatic are lung, liver, and lymph nodes. Pulmonary metastasis with hemoptysis and pneumothorax is rare but threatening. PRESENTATION OF CASE: A 77-year-old male had recurrent angiosarcoma of the scalp even with post operation radiotherapy. At the same time, recurrent pneumothorax was noted, thus he underwent wedge resection of the right upper lobe of the lung plus pleural biopsy...
February 20, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28342932/changes-in-hba2-and-hbf-in-alpha-thalassemia-carriers-with-klf1-mutation
#9
Stefania Satta, Maria Elisabetta Paglietti, Maria Carla Sollaino, Susanna Barella, Paolo Moi, Maria Franca Desogus, Franca Rosa Demartis, Laura Manunza, Raffaella Origa
α-thalassemia carriers are common in Mediterranean regions, particularly in the Sardinian population. Their haematological phenotype is characterized by reduced MCV and/or MCH with normal or slightly reduced HbA2 levels and normal HbF. Krüppel-like factor 1 (KLF1) is a pleiotropic erythroid transcription factor that is essential for haematopoiesis. Mutations in the KLF1 gene trigger a series of benign human red blood phenotypes, such as an increase in HbA2 and HBF. Recently, it has been found that KLF1 mutations were a frequent cause of borderline HbA2 levels in a group of Sardinian subjects...
March 18, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28342776/effect-of-needle-size-in-ultrasound-guided-core-needle-breast-biopsy-comparison-of-14-16-and-18-gauge-needles
#10
Michela Giuliani, Pierluigi Rinaldi, Rossella Rella, Gina Fabrizi, Federica Petta, Giorgio Carlino, Alba Di Leone, Antonino Mulè, Enida Bufi, Maurizio Romani, Paolo Belli, Lorenzo Bonomo
INTRODUCTION: The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core needle biopsy (US-CNB) of breast lesions, comparing smaller needles (16- and 18-gauge) with the 14-gauge needle, and to analyze the lesion characteristics influencing US-CNB diagnostic performance. PATIENTS AND METHODS: All the patients provided informed consent before the biopsy procedure. The data from breast lesions that had undergone US-CNB in our institution from January 2011 to January 2015 were retrospectively reviewed...
March 6, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28342323/computer-aided-tumor-diagnosis-using-shear-wave-breast-elastography
#11
Woo Kyung Moon, Yao-Sian Huang, Yan-Wei Lee, Shao-Chien Chang, Chung-Ming Lo, Min-Chun Yang, Min Sun Bae, Su Hyun Lee, Jung Min Chang, Chiun-Sheng Huang, Yi-Ting Lin, Ruey-Feng Chang
The shear wave elastography (SWE) uses the acoustic radiation force to measure the stiffness of tissues and is less operator dependent in data acquisition compared to strain elastography. However, the reproducibility of the result is still interpreter dependent. The purpose of this study is to develop a computer-aided diagnosis (CAD) method to differentiate benign from malignant breast tumors using SWE images. After applying the level set method to automatically segment the tumor contour and hue-saturation-value color transformation, SWE features including average tissue elasticity, sectional stiffness ratio, and normalized minimum distance for grouped stiffer pixels are calculated...
March 15, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28341197/label-free-quantitative-proteomics-unravels-the-importance-of-rna-processing-in-glioma-malignancy
#12
Baibin Bi, Feng Li, Jisheng Guo, Cuiling Li, Ruirui Jing, Xin Lv, Xinjun Chen, Fengqin Wang, Kazem M Azadzoi, Lin Wang, Yuguang Liu, Jing-Hua Yang
Glioma, one of the most common cancers in human, is classified to different grades according to the degrees of malignancy. Glioblastoma (GBM) is known to be the most malignant (Grade IV) whereas low-grade astrocytoma (LGA, Grade II) is relatively benign. The mechanism underlying the pathogenesis and progression of glioma malignancy remains unclear. Here we report a quantitative proteomic study to elucidate the differences between GBM and LGA using liquid chromatography and tandem mass spectrometry followed by label-free quantification...
March 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28340489/mir-34a-3p-alters-proliferation-and-apoptosis-of-meningioma-cells-in-vitro-and-is-directly-targeting-smad4-frat1-and-bcl2
#13
Tamara V Werner, Martin Hart, Ruth Nickels, Yoo-Jin Kim, Michael D Menger, Rainer M Bohle, Andreas Keller, Nicole Ludwig, Eckart Meese
Micro (mi)RNAs are short, noncoding RNAs and deregulation of miRNAs and their targets are implicated in tumor generation and progression in many cancers. Meningiomas are mostly benign, slow growing tumors of the central nervous system with a small percentage showing a malignant phenotype.Following in silico prediction of potential targets of miR-34a-3p, SMAD4, FRAT1, and BCL2 have been confirmed as targets by dual luciferase assays with co-expression of miR-34a-3p and reporter gene constructs containing the respective 3'UTRs...
March 23, 2017: Aging
https://www.readbyqxmd.com/read/28340256/sleep-disturbance-of-adults-with-a-brain-tumor-and-their-family-caregivers-a-systematic-review
#14
Megan Soohwa Jeon, Haryana M Dhillon, Meera R Agar
The high incidence and psychophysiological morbidities of sleep disturbance in cancer have been increasingly recognized. Yet, more detailed understanding of sleep disturbance and options for management have been neglected areas in both clinical care and research. Brain tumor patients have been particularly overlooked. A systematic search of the literature from 1990 to 2015 was performed to review sleep disturbance in adults with primary or secondary brain tumor and their family caregivers. Fifty eligible studies were identified, of which 12 focused on sleep, 37 reported sleep items within a health-related quality of life measure and 1 reported caregivers' sleep...
March 15, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28339311/lung-rads-category-4x-does-it-improve-prediction-of-malignancy-in-subsolid-nodules
#15
Kaman Chung, Colin Jacobs, Ernst T Scholten, Jin Mo Goo, Helmut Prosch, Nicola Sverzellati, Francesco Ciompi, Onno M Mets, Paul K Gerke, Mathias Prokop, Bram van Ginneken, Cornelia M Schaefer-Prokop
Purpose To evaluate the added value of Lung CT Screening Reporting and Data System (Lung-RADS) assessment category 4X over categories 3, 4A, and 4B for differentiating between benign and malignant subsolid nodules (SSNs). Materials and Methods SSNs on all baseline computed tomographic (CT) scans from the National Lung Cancer Trial that would have been classified as Lung-RADS category 3 or higher were identified, resulting in 374 SSNs for analysis. An experienced screening radiologist volumetrically segmented all solid cores and located all malignant SSNs visible on baseline scans...
March 24, 2017: Radiology
https://www.readbyqxmd.com/read/28339285/is-the-necrosis-wall-adc-ratio-useful-for-the-differentiation-of-benign-and-malignant-breast-lesions
#16
Irmak Durur-Subasi, Afak Durur-Karakaya, Adem Karaman, Mehmet Seker, Elif Demirci, Fatih Alper
OBJECTIVES: To determine whether the necrosis/wall apparent diffusion coefficient (ADC) ratio is useful for the malignant-benign differentiation of necrotic breast lesions. METHODS: Breast magnetic resonance imaging (MRI) was performed using a 3T system. In this retrospective study, calculation of the necrosis/wall ADC ratio was based on ADC values measured from the necrosis and from the wall of malignant and benign breast lesions by diffusion-weighted imaging (DWI)...
March 24, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28339093/rock-inhibition-as-a-potential-therapeutic-target-involved-in-apoptosis-in-hemangioma
#17
Ming-Ke Qiu, Shu-Qing Wang, Chang Pan, Yang Wang, Zhi-Wei Quan, Ying-Bin Liu, Jing-Min Ou
Gene expression was examined in hemangiomas (HA), benign, birthmark-like tumors occurring in infancy, and confirmed in HA-derived endothelial cells (HDEC), for which cell proliferation and apoptosis were also assessed. Protein and mRNA accumulation of Rho-associated protein kinase (ROCK), vascular endothelial growth factor (VEGF), Ki-67 and proliferating cell nuclear antigen was significantly higher in proliferating phase HAs than in involuting phase HAs. In contrast, p53 and caspase-3 exhibited higher levels of accumulation in involuting than proliferating HAs...
March 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28339091/fibulin-4-promotes-osteosarcoma-invasion-and-metastasis-by-inducing-epithelial-to-mesenchymal-transition-via-the-pi3k-akt-mtor-pathway
#18
Dong Zhang, Songgang Wang, Jie Chen, Haitao Liu, Jinfa Lu, Hua Jiang, Aimin Huang, Yunzhen Chen
This study explored the role of fibulin-4 in osteosarcoma progression and the possible signaling pathway involved. Fibulin-4 mRNA and protein expression in normal tissue, benign fibrous dysplasia, osteosarcoma, osteosarcoma cell lines, the normal osteoblastic cell line hFOB, and different invasive subclones were evaluated by immunohistochemistry (IHC) or immunocytochemistry (ICC) and real-time reverse transcriptase-polymerase chain reaction (real-time qRT-PCR). Using in vitro functional assays, we analyzed the invasive and proliferative abilities of different osteosarcoma cell lines and subclones with differing invasive potential...
March 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28338666/the-association-of-maternal-factors-with-epibulbar-dermoid-of-newborn-a-retrospective-matched-case-control-study
#19
S Wu, Y Fan, D Wu, J Hong, J Xu
PurposeTo determine the association of maternal factors and exposure during pregnancy with the incidence in newborns of epibulbar dermoid (ED), a congenital ocular surface benign tumor.Patients and methodsThis is a retrospective, paired case-control study in which 121 children with ED (case group) and 121 children without ED (control group) were recruited. Questionnaire-based interviews with mothers of participants were performed and maternal medical records during pregnancy were reviewed. The questionnaire investigated basic information, personal history, environmental exposure, exposure to maternal diseases, symptoms and corresponding medical treatments during pregnancy, and parental socioeconomic status...
March 24, 2017: Eye
https://www.readbyqxmd.com/read/28338551/standardizing-robotic-lobectomy-feasibility-and-safety-in-128-consecutive-lobectomies-within-a-single-healthcare-system
#20
John F Lazar, Laurence N Spier, Alan R Hartman, Richard S Lazzaro
OBJECTIVE: Single-surgeon cohorts assessing robotically assisted video-assisted thoracic (RA-VATS) lobectomy have reported good outcomes, but there are little data regarding multiple surgeons applying a standard technique in separate hospitals. The purpose of this study was to show how a standardized robotic technique is both safe and reproducible between surgeons and institutions. METHODS: From July 1, 2012, to October 1, 2013, patients undergoing RA-VATS lobectomy for both benign and malignant disease were identified from a prospectively collected database of two thoracic surgeons from different hospitals within the same healthcare system and retrospectively analyzed...
March 23, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
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